                         SEQUENCE LISTING

<110>  CASPR BIOTECH CORPORATION
       CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS 
       (CONICET)
 
<120>  NOVEL CLASS 2 CRISPR-CAS RNA-GUIDED ENDONUCLEASES

<130>  CABI-002/02WO 337081-2006

<150>  US 63/058,448
<151>  2020-07-29

<150>  US 62/898,340
<151>  2019-09-10

<160>  249   

<170>  PatentIn version 3.5

<210>  1
<211>  1038
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9.1

<400>  1

Met Gln Arg Ile Phe Gly Leu Asp Ile Gly Thr Thr Ser Ile Gly Phe 
1               5                   10                  15      


Ala Val Ile Asp His Asp Arg Asp Gln Gly Val Gly Arg Ile His Arg 
            20                  25                  30          


Leu Gly Ala Arg Ile Phe Pro Glu Ala Arg Asp Glu Lys Gly Thr Pro 
        35                  40                  45              


Leu Asn Gln His Arg Arg Gln Lys Arg Leu Ala Arg Arg Gln Leu Arg 
    50                  55                  60                  


Arg Arg Arg Leu Arg Arg Lys Ala Leu Asn Glu Leu Leu Ser Ala Arg 
65                  70                  75                  80  


Gly Met Leu Pro Arg Phe Gly Thr Ser Ala Trp His Asp Ala Met Ala 
                85                  90                  95      


Leu Asp Pro Tyr Ala Leu Arg Ala Arg Gly Thr Glu Glu Ala Leu Gln 
            100                 105                 110         


Pro Val Glu Val Gly Arg Ala Leu Tyr His Leu Ala Gln Arg Arg His 
        115                 120                 125             


Phe Lys Pro Arg Asp Glu Ala Ala Glu Ala Asp Glu Gln Glu Val Gly 
    130                 135                 140                 


Asp Gln Glu Ala Glu Thr Lys Arg Glu Lys Leu Leu Gln Ala Leu Arg 
145                 150                 155                 160 


Arg Ser Gly Arg Thr Leu Gly Gln Glu Leu Ala Ala Arg Gly Pro His 
                165                 170                 175     


Glu Arg Lys Arg His Glu His Ala Leu Arg Ser Thr Val Glu Thr Glu 
            180                 185                 190         


Phe Glu Arg Leu Leu Thr Ala Gln Ala Arg His His Glu Ile Leu Arg 
        195                 200                 205             


Asp Pro Glu Phe Val Glu Glu Leu Arg Glu Thr Ile Phe Ala Gln Arg 
    210                 215                 220                 


Pro Val Phe Trp Arg Thr Ser Thr Leu Gly Thr Cys Pro Phe Val Pro 
225                 230                 235                 240 


Gly Ala Pro Leu Cys Pro Lys Gly Ala Trp Leu Ser Arg Gln Arg Arg 
                245                 250                 255     


Met Leu Glu Gln Val Asn Asn Leu Ala Ile Thr Gly Gly Asn Ala Arg 
            260                 265                 270         


Pro Leu Asp His Glu Glu Arg Arg Ala Ile Leu Ala Val Leu Gln Thr 
        275                 280                 285             


Gln Ala Ser Met Ser Trp Gly Ala Val Arg Thr Ala Leu Lys Pro Leu 
    290                 295                 300                 


Phe Lys Ala Arg Gly Glu Ala Gly Ala Glu Arg Arg Leu Arg Phe Asn 
305                 310                 315                 320 


Leu Glu Glu Gly Gly Gly Lys Thr Leu Leu Gly Asn Pro Leu Glu Ala 
                325                 330                 335     


Lys Leu Ala Arg Ile Phe Gly Glu Ala Trp Ala Thr His Pro His Arg 
            340                 345                 350         


Asp Ala Ile Arg Glu Thr Ile His Asp Arg Leu Phe Ala Ala Thr Tyr 
        355                 360                 365             


Asn Ala Lys Gly Ala Gln Arg Ile Val Ile Leu Pro Ala Ser Gln Arg 
    370                 375                 380                 


Ala Glu Arg Met Arg Gly Val Ile Ala Gly Leu Gln Ala Asp Phe Gly 
385                 390                 395                 400 


Leu Ser His Glu Gln Ala Met Ala Leu Ala Glu Leu Pro Leu Thr Pro 
                405                 410                 415     


Gly Trp Glu Pro Tyr Ser Ser Glu Ala Leu Arg Ala Leu Met Pro Lys 
            420                 425                 430         


Leu Glu Glu Gly Val Arg Phe Gly Ala Leu Val Val Ala Pro Glu Trp 
        435                 440                 445             


Glu Asp Trp Arg Glu Ala Thr Phe Pro Gln Arg Glu Arg Pro Thr Gly 
    450                 455                 460                 


Glu Val Leu Asp Leu Leu Pro Ser Pro Lys Cys His Asp Glu Ser Arg 
465                 470                 475                 480 


Arg Gln Thr Arg Leu Arg Asn Pro Thr Val Leu Arg Thr Gln Asn Glu 
                485                 490                 495     


Leu Arg Lys Val Val Asn Asn Leu Ile Arg Ala His Gly Lys Pro Asp 
            500                 505                 510         


Ile Ile Arg Val Glu Val Ala Arg Glu Val Gly Leu Ser Lys Arg Glu 
        515                 520                 525             


Arg Glu Asp Arg Tyr Asn Gly Met Arg Arg Gln Glu Arg Gln Arg Gln 
    530                 535                 540                 


Ala Ala Ile Lys Asp Leu Gln Ala Lys Gly Phe Ala Glu Pro Ser Arg 
545                 550                 555                 560 


Ala Asp Val Glu Lys Trp Leu Leu Trp Lys Glu Ser Lys Glu Thr Cys 
                565                 570                 575     


Pro Tyr Thr Gly Asp Lys Ile Cys Phe Asp Ala Leu Phe Arg Arg Gly 
            580                 585                 590         


Glu Phe Gln Val Glu His Ile Trp Pro Arg Ser Arg Ser Phe Asp Asp 
        595                 600                 605             


Ser Phe Arg Asn Lys Thr Leu Cys Arg Arg Asp Val Asn Leu Ala Lys 
    610                 615                 620                 


Gly Asn Gln Thr Pro Phe Glu Phe Phe Glu Ser Arg Pro Glu Glu Trp 
625                 630                 635                 640 


Glu Ala Val Lys Arg Arg Leu Asp Gly Leu Gln Ala Lys Arg Ala Gly 
                645                 650                 655     


Gly Glu Gly Met Ala Arg Gly Lys Val Lys Arg Phe Val Ala Ser Thr 
            660                 665                 670         


Leu Pro Asp Asp Phe Ala Gln Arg Gln Leu Asn Asp Thr Gly Trp Ala 
        675                 680                 685             


Ala Arg Glu Ala Val Ala Phe Leu Lys Arg Leu Trp Pro Asp Glu Gly 
    690                 695                 700                 


Gln Ala Ala Pro Val Arg Val Gln Ala Val Thr Gly Arg Val Thr Ala 
705                 710                 715                 720 


Gln Leu Arg His Leu Gly Gly Leu Asp Gly Val Leu Ser Asp Gly Ala 
                725                 730                 735     


Arg Lys Thr Arg Asp Asp His Arg His His Ala Val Asp Ala Leu Val 
            740                 745                 750         


Val Ala Cys Thr His Pro Gly Met Thr Glu Arg Leu Ser Arg Tyr Trp 
        755                 760                 765             


Gln Gln Lys Glu Asp Glu Arg Ala Glu Arg Pro Gln Leu Asp Pro Pro 
    770                 775                 780                 


Trp Pro Thr Ile Arg Ala Asp Ala Glu Ala Ala Lys Asp Leu Ile Val 
785                 790                 795                 800 


Val Ser His Arg Val Arg Lys Lys Ile Ser Gly Pro Phe His Lys Glu 
                805                 810                 815     


Thr Val Tyr Gly Ala Thr Asp Glu Arg Glu Val Thr Arg Gly Leu Glu 
            820                 825                 830         


Tyr Glu Lys Phe Val Thr Arg Lys Arg Val Glu Asp Leu Thr Lys Ser 
        835                 840                 845             


Met Leu Ala Asp Ile Arg Asp Asp Arg Val Arg Gln Ile Val Thr Ala 
    850                 855                 860                 


Trp Val Ala Glu Arg Gly Gly Asp Pro Lys Lys Ala Phe Pro Pro Tyr 
865                 870                 875                 880 


Pro Thr Leu Gly Ser Ser Gly Pro Glu Ile Arg Lys Val Arg Val Leu 
                885                 890                 895     


Ile Arg Arg Gln Pro Thr Leu Met Ala Arg Ala Ala Thr Gly Phe Ala 
            900                 905                 910         


Asp Leu Gly Ala Asn His His Val Ala Ile Tyr Lys Thr Ala Asp Glu 
        915                 920                 925             


Arg Phe Ala Phe Glu Val Val Ser Leu Leu Glu Val Ala Arg Arg Val 
    930                 935                 940                 


Asp Arg Gly Glu Pro Pro Val Lys Arg Gln Arg Gly Asp Glu Lys Leu 
945                 950                 955                 960 


Val Met Ser Leu Ala Gln Gly Asp Leu Ile Arg Phe Ala Lys Thr Pro 
                965                 970                 975     


Asp Ala Glu Ala Ala Ile Trp Arg Val Gln Lys Ile Ala Thr Lys Gly 
            980                 985                 990         


Gln Ile Ser Leu Leu His His Asp  Asp Ala Ser Pro Lys  Glu Pro Ser 
        995                 1000                 1005             


Leu Phe  Glu Pro Met Val Gly  Gly Leu Met Ala Arg  Asn Pro Glu 
    1010                 1015                 1020             


Lys Leu  Ala Val Asp Pro Ile  Gly Arg Val Arg Lys  Ala Gly Asp 
    1025                 1030                 1035             


<210>  2
<211>  1375
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9.2

<400>  2

Met Lys Lys Glu Lys Val Tyr Met Gly Leu Asp Leu Gly Thr Asn Ser 
1               5                   10                  15      


Val Gly Trp Ala Val Thr Asp Asn Asp Tyr Lys Val Leu Lys Phe Lys 
            20                  25                  30          


Arg Arg Ala Met Trp Gly Val Arg Leu Phe Asn Glu Ala Asn Pro Ala 
        35                  40                  45              


Val Glu Arg Arg Val Ala Arg Ser Asn Arg Arg Arg Leu Ala Arg Lys 
    50                  55                  60                  


Lys Gln Arg Val Ala Trp Leu Lys Glu Ile Phe Lys Asn Ser Ile Ser 
65                  70                  75                  80  


Glu Ile Asp Pro Glu Phe Phe Asp Arg Leu Glu Gln Ser Ala Leu Trp 
                85                  90                  95      


Ala Glu Asp Lys Asn Val Ala Gly Lys Tyr Ser Leu Phe Asn Glu Lys 
            100                 105                 110         


Lys Leu Thr Asp Lys Thr Phe Tyr Arg Lys Phe Pro Thr Val Phe His 
        115                 120                 125             


Leu Lys Lys Ala Leu Met Asp Gly Lys Ile Lys Lys Pro Asp Ile Arg 
    130                 135                 140                 


Phe Val Tyr Leu Ala Leu Ser His Tyr Leu Gln Asn Arg Gly His Phe 
145                 150                 155                 160 


Leu Leu Glu Asn Glu Leu Asn Ser Val Glu Asp Ile Asp Ile Arg Asp 
                165                 170                 175     


Ile Phe Asn Ser Leu Asn Glu Arg Ile His Val Leu Ile Asp Ser Gly 
            180                 185                 190         


Asp Asp Met Val Pro Ala Phe Asp Leu Thr Asn Leu Asp Asp Leu Lys 
        195                 200                 205             


Gln Ile Ala Thr Asp Thr Asn Ile Ser Gly Lys Thr Gln Glu Lys Glu 
    210                 215                 220                 


Ala Phe Ile Lys Thr Leu Leu Asn Gly Ala Lys Gln Pro Ala Leu Glu 
225                 230                 235                 240 


Ala Ile Ile Lys Leu Cys Thr Gly Gly Ser Ala Asn Leu Ser Lys Ile 
                245                 250                 255     


Phe Gly Asp Met Phe Glu Phe Glu Ser Glu Ile Lys Ser Ile Ser Phe 
            260                 265                 270         


Glu Lys Ala Asn Phe Glu Asp Glu Ile Ala Pro Lys Leu Gln Asp Cys 
        275                 280                 285             


Leu Gly Asp Tyr Tyr Gln Ile Ile Glu Leu Ala Gln Gln Ile Tyr Ser 
    290                 295                 300                 


Trp Tyr Thr Leu Tyr Lys Val Cys Ser Gly Arg Pro Ser Val Ser His 
305                 310                 315                 320 


Ala Lys Val Glu Asp Tyr Glu Lys His Lys Glu Gln Leu Ser His Leu 
                325                 330                 335     


Lys Val Leu Val Arg Lys His Phe Ser Lys Asn Val Tyr Arg Glu Ile 
            340                 345                 350         


Phe Arg Lys Glu Asp Asp Lys Ile His Asn Tyr Val Ser Tyr Ile Ser 
        355                 360                 365             


Gly Lys Lys Asp Arg Asp Glu Phe Tyr Lys Tyr Leu Lys Lys Thr Leu 
    370                 375                 380                 


Glu Lys Lys Ser Thr Phe Lys Lys Thr Ser Glu Phe Glu Asn Ile Ser 
385                 390                 395                 400 


Arg Ala Ile Glu Gln Gln Asn Tyr Leu Pro Lys Gln Arg Val Lys Asp 
                405                 410                 415     


Asn Ser Val Val Pro Gln Gln Leu Tyr Lys Gln Glu Ile Val Lys Ile 
            420                 425                 430         


Leu Asn Asn Leu Ser Ser His Tyr Pro Phe Leu Ser Gln Lys Thr Asp 
        435                 440                 445             


Gly Ile Ser Asn Arg Glu Lys Ile Ile Lys Ile Phe Glu Tyr Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Cys Asp Ile His Arg Ala Gly Asp Asp 
465                 470                 475                 480 


Gly Phe Ser Trp Leu Val Arg Asp Cys Ser Lys Lys Ile Thr Pro Trp 
                485                 490                 495     


Asn Phe Glu Gln Val Val Asp Ile Pro Gln Ser Ala Glu Asn Phe Ile 
            500                 505                 510         


Lys Asn Met Thr Arg Lys Cys Thr Tyr Leu Lys Gln Tyr Asn Val Leu 
        515                 520                 525             


Pro Lys Asn Ser Leu Leu Tyr Ser Glu Tyr Ser Val Leu Asn Glu Leu 
    530                 535                 540                 


Asn Asn Val Arg Ile Lys Thr Lys Lys Leu Thr Pro Lys Leu Lys Glu 
545                 550                 555                 560 


Lys Met Leu Asn Thr Leu Phe Arg Gln Lys Lys Asn Ile Ser Ile Thr 
                565                 570                 575     


Ser Leu Ile His Trp Leu Val Ser Glu Gly Val Tyr Glu Lys Gly Glu 
            580                 585                 590         


Ile Glu Lys Ser Asp Val Ser Gly Val Asp Ser Asn Phe Thr Ser Ser 
        595                 600                 605             


Leu Ser Ala Ala Ile Ser Phe Asp Arg Ile Ile Gly Glu Lys Met Lys 
    610                 615                 620                 


Asn Lys Lys Thr Gln Lys Met Val Glu Glu Ile Ile Asn Trp Leu Ala 
625                 630                 635                 640 


Leu Phe Ser Asp Lys Lys Ile Leu Gln Gln Lys Ile Val Glu Lys Tyr 
                645                 650                 655     


Gln Asp Lys Val Ser Gln Glu Gln Ile Gly Lys Ile Leu Arg Leu Asn 
            660                 665                 670         


Leu Ser Gly Trp Gly Arg Leu Ser Ser Glu Phe Leu Gln Leu Lys Asn 
        675                 680                 685             


Ser Gln Pro Gly Glu His Asp Gly Lys Thr Leu Ile Asn Ile Met Arg 
    690                 695                 700                 


Gln Thr Gln Met Asn Leu Met Glu Ile Ile His Ser Pro Gln Phe Ser 
705                 710                 715                 720 


Phe Asn Thr Val Ile Glu Thr Glu Ala Lys Lys Gln Leu Thr Gly His 
                725                 730                 735     


Ile Thr His Ser His Val Glu Ala Leu Tyr Cys Ser Pro Val Val Lys 
            740                 745                 750         


Lys Gln Ile Trp Gln Ala Leu Gln Ile Ala Leu Glu Leu Lys Lys Thr 
        755                 760                 765             


Leu Lys Lys Asp Pro Asn Lys Ile Phe Val Glu Thr Thr Arg His Glu 
    770                 775                 780                 


Gly Glu Lys Lys Arg Thr Thr Ser Arg His Lys Gln Leu Leu Glu Leu 
785                 790                 795                 800 


Tyr Gln Ala Ala Lys Ser His Leu Pro Asp Leu Thr Lys Ser Ile Lys 
                805                 810                 815     


Glu Leu Asn Asp Ala Leu Lys Asp Thr Glu Pro Glu Lys Met Lys Arg 
            820                 825                 830         


Lys Lys Leu Phe His Tyr Tyr Lys Gln Leu Gly Arg Cys Met Tyr Thr 
        835                 840                 845             


Gly Arg Pro Ile Ser Leu Glu Asp Leu Phe Thr Asn Lys Tyr Asp Ile 
    850                 855                 860                 


Asp His Ile Tyr Pro Gln Ser Leu Thr Lys Asp Asp Ser Phe Thr Asn 
865                 870                 875                 880 


Thr Val Leu Val Glu Arg Leu Ser Asn Ala Glu Lys Ser Asp Ala Phe 
                885                 890                 895     


Pro Leu Asp Ser Lys Thr Arg Lys Asp Arg Gln Gly Leu Trp Arg Cys 
            900                 905                 910         


Leu Arg Arg Asn Gly Leu Ile Thr Lys Glu Lys Tyr Tyr Arg Leu Thr 
        915                 920                 925             


Arg Glu Thr Pro Leu Ser Glu Glu Glu Lys Ala Ala Phe Ile Arg Arg 
    930                 935                 940                 


Gln Leu Val Glu Thr Ser Gln Thr Thr Lys Glu Val Ile Arg Phe Leu 
945                 950                 955                 960 


Ala Thr Leu Phe Pro Lys Ser Lys Val Val Tyr Val Lys Ser Gly Asn 
                965                 970                 975     


Val Ser Asp Phe Arg Arg Asp Phe Ser Pro Ser Leu Pro Glu Asn Lys 
            980                 985                 990         


Thr Asn Gly Lys Asp Pro Lys Gly  Ile Thr Asp Tyr Ser  Met Ile Lys 
        995                 1000                 1005             


Val Arg  Glu Ile Asn Asp Leu  His His Ala Lys Asp  Ala Tyr Leu 
    1010                 1015                 1020             


Asn Ile  Val Val Gly Asn Val  Tyr Asp Thr Lys Phe  Arg Tyr Arg 
    1025                 1030                 1035             


Gly Lys  Asp Leu Thr Ala Ile  Val Arg Glu Lys Ala  Arg Gln Tyr 
    1040                 1045                 1050             


His Leu  Ser Arg Leu Phe Leu  Tyr Ser Thr Asp Gly  Ala Trp Ile 
    1055                 1060                 1065             


Gly Ala  Ala Asp Glu Asn Arg  Gly Lys Gln Arg Pro  Ser Ile Glu 
    1070                 1075                 1080             


Thr Val  Ile Ala Glu Met Arg  Arg Asn Ser Cys Gln  Val Thr Trp 
    1085                 1090                 1095             


Glu Ala  Val Phe Lys Lys Gly  Gln Leu Trp Asp Met  Asn Ala Lys 
    1100                 1105                 1110             


Ser Lys  Arg Pro Gly Leu Leu  Pro Ile Lys Lys Glu  Leu Ser Asp 
    1115                 1120                 1125             


Thr Ala  Lys Tyr Gly Gly Tyr  Gln Gly Lys Thr Ala  Ser Tyr Phe 
    1130                 1135                 1140             


Val Val  Val Glu Tyr Glu Asn  Lys Lys Gly Glu Arg  Glu Lys Lys 
    1145                 1150                 1155             


Leu Glu  Ser Val Pro Ile Tyr  Val Lys Ala Leu Ser  Lys Gln Lys 
    1160                 1165                 1170             


Pro Asp  Ala Val Asn Ser Phe  Leu Arg Asp Thr Leu  Gly Leu Glu 
    1175                 1180                 1185             


Lys Pro  Ser Val Met Val Asp  Asn Ile Lys Ile Gly  Ser Ile Val 
    1190                 1195                 1200             


Glu Ile  Asn Gly Ala Arg Met  Val Leu Thr Gly Asn  Asn Glu Val 
    1205                 1210                 1215             


Leu Val  Phe Gly Arg Ile Ala  Ser Gln Leu Ile Leu  Asp Ile Thr 
    1220                 1225                 1230             


Met Ala  Ala Tyr Leu Lys Arg  Met Phe Lys Leu Leu  Ala Asp Thr 
    1235                 1240                 1245             


Ala Lys  Ile Lys Glu Asn Asn  Val Tyr Phe Lys Asn  Cys Gly Tyr 
    1250                 1255                 1260             


Leu Asp  Lys Glu Thr Asn Leu  Ala Val Tyr Asp Thr  Phe Ile Ala 
    1265                 1270                 1275             


Lys Leu  Lys Leu Pro Arg Tyr  Ala Gln Ile Ile Thr  His Ser Leu 
    1280                 1285                 1290             


Tyr Glu  Lys Met Glu Ser Asn  Arg Asp Val Phe Ile  Asn Leu Ser 
    1295                 1300                 1305             


Leu Ala  Asp Gln Cys Asn Leu  Leu Ala Gly Val Leu  Pro Ala Leu 
    1310                 1315                 1320             


Gln Cys  Asn Ser Gln Asn Ala  Asp Leu Ser Leu Leu  Gly Glu Gly 
    1325                 1330                 1335             


Lys Ala  Val Gly Asn Ile Ala  Phe Ser Lys Asn Ala  Ile Leu Lys 
    1340                 1345                 1350             


Lys Asn  Gln Val Arg Leu Val  Asp Cys Ser Ile Thr  Gly Leu Phe 
    1355                 1360                 1365             


Glu Asn  Ser Arg Asn Met Ala  
    1370                 1375 


<210>  3
<211>  1254
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12a.1

<400>  3

Met Lys Val Ser Thr Trp Asp Ser Phe Thr Asn Gln Tyr Pro Leu Thr 
1               5                   10                  15      


Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Gln Lys 
            20                  25                  30          


Ile Gln Asp Arg Asn Leu Ile Thr Glu Asp Glu Gln Arg Gln Lys Asp 
        35                  40                  45              


Phe Asn Lys Val Lys Lys Ile Met Asp Gly Tyr Tyr Lys Gln Phe Ile 
    50                  55                  60                  


Glu Glu Cys Leu Glu Gly Ala Lys Ile Pro Leu Lys Lys Leu Glu Glu 
65                  70                  75                  80  


Asn Asn Asn Ala Tyr Thr Lys Leu Lys Lys Asp Pro Tyr Asn Lys Lys 
                85                  90                  95      


Leu Arg Glu Glu Tyr Ala Lys Leu Gln Lys Gln Leu Arg Lys Leu Ile 
            100                 105                 110         


His Asp Glu Ile Asn Lys Lys Glu Glu Phe Lys Tyr Leu Phe Lys Lys 
        115                 120                 125             


Glu Phe Ile Lys Lys Ile Leu Pro Glu Trp Leu Glu Lys Lys Gly Lys 
    130                 135                 140                 


Lys Glu Glu Leu Lys Glu Ile Glu Lys Phe Asp Lys Trp Val Thr Tyr 
145                 150                 155                 160 


Phe Ser Gly Phe Phe Asn Asn Arg Lys Asn Val Phe Ser Ser Asp Glu 
                165                 170                 175     


Ile Ser Thr Ser Met Ile Tyr Arg Ile Val Asn Asp Asn Leu Pro Lys 
            180                 185                 190         


Phe Leu Asp Asp Val Ser Arg Phe Gly Glu Ile Thr Arg Tyr Lys Glu 
        195                 200                 205             


Phe Asp Ala Asn Gln Ile Glu Glu Asn Phe Glu Ser Glu Leu Asn Gly 
    210                 215                 220                 


Glu Lys Leu Lys Asp Phe Phe Asn Leu Lys Asn Phe Asn Asn Cys Leu 
225                 230                 235                 240 


Asn Gln Glu Gly Ile Glu Lys Phe Asn Leu Ile Ile Gly Gly Lys Ser 
                245                 250                 255     


Glu Glu Gly Asn Asn Lys Ile Lys Gly Leu Asn Glu Leu Val Asn Glu 
            260                 265                 270         


Leu Ala Gln Lys Gln Ala Asp Lys Asn Glu Gln Lys Lys Val Arg Lys 
        275                 280                 285             


Leu Lys Leu Ala Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Lys Ser 
    290                 295                 300                 


Ser Ser Phe Ala Phe Glu Lys Phe Glu Glu Asn Thr Glu Val Phe Asp 
305                 310                 315                 320 


Ala Ile Asp Glu Phe Tyr Asp Lys Ile Ser Leu Glu Thr Leu Lys Lys 
                325                 330                 335     


Ile Glu Ala Thr Leu Glu Lys Leu Glu Glu Lys Asp Leu Glu Leu Val 
            340                 345                 350         


Tyr Leu Lys Asn Asp Arg Cys Leu Thr Gly Ile Ser Gln Glu Val Phe 
        355                 360                 365             


Gly Asp Arg Glu Arg Val Leu Gln Ala Leu Arg Glu Tyr Ala Lys Thr 
    370                 375                 380                 


Glu Leu Gly Leu Lys Thr Asp Lys Lys Ile Glu Lys Trp Met Lys Lys 
385                 390                 395                 400 


Gly Arg Tyr Ser Ile His Glu Ile Glu Ser Gly Leu Lys Lys Ile Gly 
                405                 410                 415     


Ser Thr Gly His Pro Ile Cys Asn Tyr Phe Ser Lys Leu Glu Glu Lys 
            420                 425                 430         


Lys Thr Asn Leu Ile Gln Glu Ile Lys Lys Ala Arg Thr Glu Tyr Glu 
        435                 440                 445             


Lys Ile Ser Asp Lys Lys Lys Lys Leu Thr Ala Glu Ser Gln Glu Pro 
    450                 455                 460                 


Asn Val Ala Arg Ile Lys Ala Leu Leu Asp Ser Ile Met Arg Leu Tyr 
465                 470                 475                 480 


His Phe Ile Lys Pro Leu Asn Ile Asn Phe Lys Asn Lys Lys Glu Lys 
                485                 490                 495     


Asp Ser Glu Ala Leu Glu Thr Asp Asn Asp Phe Tyr Asn Asp Phe Asp 
            500                 505                 510         


Glu Ser Phe Ala Glu Leu Gly Asn Ile Ile Pro Leu Tyr Asn Gln Val 
        515                 520                 525             


Arg Asn Tyr Val Thr Gln Lys Pro Phe Ser Thr Glu Lys Phe Lys Leu 
    530                 535                 540                 


Asn Phe Glu Asn Pro Lys Leu Leu Ser Gly Trp Asp Lys Asn Lys Glu 
545                 550                 555                 560 


Lys Asp Tyr Tyr Ser Val Ile Leu Arg Lys Glu Glu Ser Tyr Tyr Leu 
                565                 570                 575     


Ala Ile Met Thr Pro Lys Gln Lys Asn Val Phe Asp Glu Leu Glu Arg 
            580                 585                 590         


Leu Pro Ala Gly Lys Asn Tyr Phe Glu Lys Ile Asp Tyr Lys Leu Leu 
        595                 600                 605             


Pro Thr Pro Glu Lys Asn Leu Pro Arg Ile Leu Phe Ala Lys Lys Asn 
    610                 615                 620                 


Ile Ser Phe Tyr Lys Pro Ser Lys Glu Ile Glu Ala Ile Arg Asn His 
625                 630                 635                 640 


Ser Ala His Thr Lys His Gly Asn Pro Gln Asn Gly Phe Lys Lys Arg 
                645                 650                 655     


Asp Phe Arg Leu Ser Asp Cys His Lys Met Ile Asp Phe Tyr Lys Lys 
            660                 665                 670         


Ser Ile Gln Lys His Pro Glu Trp Lys Glu Tyr Asp Phe Gln Phe Lys 
        675                 680                 685             


Lys Thr Glu Asp Tyr Val Asp Ile Ser Glu Phe Tyr Lys Glu Val Ser 
    690                 695                 700                 


Asp Gln Gly Tyr Lys Ile Glu Phe Lys Lys Ile Ser Glu Lys Tyr Leu 
705                 710                 715                 720 


Leu Asp Leu Val Glu Glu Gly Lys Leu Tyr Leu Phe Gln Ile Trp Asn 
                725                 730                 735     


Lys Asp Phe Ser Lys Tyr Ser Glu Gly Arg Lys Asn Leu His Thr Ile 
            740                 745                 750         


Tyr Trp Lys Glu Leu Phe Ser Lys Glu Asn Leu Ser Asp Ile Thr Tyr 
        755                 760                 765             


Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr Arg Pro Lys Ser Met Glu 
    770                 775                 780                 


Arg Lys Val Thr His Pro Lys Asn Gln Lys Ile Glu Asn Lys Asp Pro 
785                 790                 795                 800 


Ile Lys Gly Lys Lys Phe Ser Lys Phe Lys Tyr Asp Phe Ile Lys Asn 
                805                 810                 815     


Lys Arg Tyr Thr Glu Asp Arg Phe Phe Phe His Cys Pro Ile Thr Leu 
            820                 825                 830         


Asn Phe Gln Ala Arg Asp Gly Ser Lys Thr Ile Asn Lys Arg Val Asn 
        835                 840                 845             


Asp His Ile Arg Glu Thr Lys Asp Asp Ile Phe Val Leu Ser Ile Asp 
    850                 855                 860                 


Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu Leu Asn Ser Lys Gly 
865                 870                 875                 880 


Glu Ile Gln Glu Gln Gly Ser Phe Asn Val Ile Ser Asp Asp Lys Glu 
                885                 890                 895     


Arg Lys Arg Asp Tyr His Glu Lys Leu Asp Glu Arg Glu Lys Glu Arg 
            900                 905                 910         


Asp Lys Ala Arg Lys Ser Trp Gln Lys Ile Glu Thr Ile Lys Lys Leu 
        915                 920                 925             


Lys Asp Gly Tyr Leu Ser Gln Ile Val His Lys Ile Ala Lys Leu Ala 
    930                 935                 940                 


Ile Glu Lys Asn Ala Ile Ile Val Leu Glu Asp Leu Asn Leu Asp Phe 
945                 950                 955                 960 


Lys Arg Gly Arg Leu Lys Ile Glu Lys Gln Val Tyr Gln Lys Phe Glu 
                965                 970                 975     


Lys Lys Leu Ile Asp Lys Leu Asn Tyr Leu Val Phe Lys Glu Arg Thr 
            980                 985                 990         


Glu Lys Glu Ala Gly Gly Ser Leu  Asn Ala Tyr Gln Leu  Thr Gly Lys 
        995                 1000                 1005             


Phe Glu  Gly Phe Lys Lys Leu  Gly Lys Glu Thr Gly  Ile Ile Tyr 
    1010                 1015                 1020             


Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile Cys Pro  Lys Thr Gly 
    1025                 1030                 1035             


Phe Val  Asn Leu Leu Arg Pro  Lys Phe Lys Asn Ile  Glu Lys Ala 
    1040                 1045                 1050             


Lys Glu  Phe Phe Lys Lys Phe  Asn Tyr Ile Lys Tyr  Asp Ser Ser 
    1055                 1060                 1065             


Glu Gly  Leu Phe Glu Phe Asn  Phe Asp Tyr Ser Lys  Phe Ile Lys 
    1070                 1075                 1080             


Asn Gly  Lys Lys Glu Thr Lys  Ile Ile Gln Asp Asn  Trp Ser Val 
    1085                 1090                 1095             


Tyr Ser  Asn Gly Thr Lys Leu  Val Gly Phe Arg Asn  Lys Asn Lys 
    1100                 1105                 1110             


Asn Asn  Ser Trp Asp Thr Lys  Glu Val Lys Pro Asn  Glu Lys Leu 
    1115                 1120                 1125             


Lys Ile  Leu Phe Lys Glu Tyr  Gly Val Ser Phe Gln  Lys Asp Glu 
    1130                 1135                 1140             


Asn Ile  Ile Ser Gln Ile Ala  Ser Gln Asn Lys Lys  Ala Phe Phe 
    1145                 1150                 1155             


Glu Asn  Leu Ile Lys Ile Phe  Lys Thr Ile Leu Met  Leu Arg Asn 
    1160                 1165                 1170             


Ser Arg  Lys Asp Pro Glu Glu  Asp Tyr Val Leu Ser  Cys Val Lys 
    1175                 1180                 1185             


Asp Glu  Asn Gly Glu Phe Phe  Asp Ser Arg Lys Ala  Lys Asp Asn 
    1190                 1195                 1200             


Glu Pro  Lys Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Gly Leu 
    1205                 1210                 1215             


Lys Gly  Leu Met Leu Leu Glu  Arg Ile Lys Ala Asn  Lys Gly Lys 
    1220                 1225                 1230             


Lys Lys  Leu Asp Leu Leu Ile  Ser Arg Asn Asp Phe  Ile Asn Phe 
    1235                 1240                 1245             


Ala Val  Glu Arg Ser Lys 
    1250                 


<210>  4
<211>  1281
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12p

<400>  4

Met Lys Lys Ser Ile Phe Asp Gln Phe Val Asn Gln Tyr Ala Leu Ser 
1               5                   10                  15      


Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Glu Thr Gly Arg Met 
            20                  25                  30          


Leu Glu Glu Ala Lys Val Phe Ala Lys Asp Glu Thr Ile Lys Lys Lys 
        35                  40                  45              


Tyr Glu Ala Thr Lys Pro Phe Phe Asn Lys Leu His Arg Glu Phe Val 
    50                  55                  60                  


Glu Glu Ala Leu Asn Glu Val Glu Leu Ala Gly Leu Pro Glu Tyr Phe 
65                  70                  75                  80  


Glu Ile Phe Lys Tyr Trp Lys Arg Tyr Lys Lys Lys Phe Glu Lys Asp 
                85                  90                  95      


Leu Gln Lys Lys Glu Lys Glu Leu Arg Lys Ser Val Val Gly Phe Phe 
            100                 105                 110         


Asn Ala Gln Ala Lys Glu Trp Ala Lys Lys Tyr Glu Thr Leu Gly Val 
        115                 120                 125             


Lys Lys Lys Asp Val Gly Leu Leu Phe Glu Glu Asn Val Phe Ala Ile 
    130                 135                 140                 


Leu Lys Glu Arg Tyr Gly Asn Glu Glu Gly Ser Gln Ile Val Asp Glu 
145                 150                 155                 160 


Ser Thr Gly Lys Asp Val Ser Ile Phe Asp Ser Trp Lys Gly Phe Thr 
                165                 170                 175     


Gly Tyr Phe Ile Lys Phe Gln Glu Thr Arg Lys Asn Phe Tyr Lys Asp 
            180                 185                 190         


Asp Gly Thr Ala Thr Ala Leu Ala Thr Arg Ile Ile Asp Gln Asn Leu 
        195                 200                 205             


Lys Arg Phe Cys Asp Asn Leu Leu Ile Phe Glu Ser Ile Arg Asp Lys 
    210                 215                 220                 


Ile Asp Phe Ser Glu Val Glu Gln Thr Met Gly Asn Ser Ile Asp Lys 
225                 230                 235                 240 


Val Phe Ser Val Ile Phe Tyr Ser Ser Cys Leu Leu Gln Glu Gly Ile 
                245                 250                 255     


Asp Phe Tyr Asn Cys Val Leu Gly Gly Glu Thr Leu Pro Asn Gly Glu 
            260                 265                 270         


Lys Arg Gln Gly Ile Asn Glu Leu Ile Asn Leu Tyr Arg Gln Lys Thr 
        275                 280                 285             


Ser Glu Lys Val Pro Phe Leu Lys Leu Leu Asp Lys Gln Ile Leu Ser 
    290                 295                 300                 


Glu Lys Glu Lys Phe Met Asp Glu Ile Glu Asn Asp Glu Ala Leu Leu 
305                 310                 315                 320 


Asp Thr Leu Lys Ile Phe Arg Lys Ser Ala Glu Glu Lys Thr Thr Leu 
                325                 330                 335     


Leu Lys Asn Ile Phe Gly Asp Phe Val Met Asn Gln Gly Lys Tyr Asp 
            340                 345                 350         


Leu Ala Gln Ile Tyr Ile Ser Arg Glu Ser Leu Asn Thr Ile Ser Arg 
        355                 360                 365             


Lys Trp Thr Ser Glu Thr Asp Ile Phe Glu Asp Ser Leu Tyr Glu Val 
    370                 375                 380                 


Leu Lys Lys Ser Lys Ile Val Ser Ala Ser Val Lys Lys Lys Asp Gly 
385                 390                 395                 400 


Gly Tyr Ala Phe Pro Glu Phe Ile Ala Leu Ile Tyr Val Lys Ser Ala 
                405                 410                 415     


Leu Glu Gln Ile Pro Thr Glu Lys Phe Trp Lys Glu Arg Tyr Tyr Lys 
            420                 425                 430         


Asn Ile Gly Asp Val Leu Asn Lys Gly Phe Leu Asn Gly Lys Glu Gly 
        435                 440                 445             


Val Trp Leu Gln Phe Leu Leu Ile Phe Asp Phe Glu Phe Asn Ser Leu 
    450                 455                 460                 


Phe Glu Arg Glu Ile Ile Asp Glu Asn Gly Asp Lys Lys Val Ala Gly 
465                 470                 475                 480 


Tyr Asn Leu Phe Ala Lys Gly Phe Asp Asp Leu Leu Asn Asn Phe Lys 
                485                 490                 495     


Tyr Asp Gln Lys Ala Lys Val Val Ile Lys Asp Phe Ala Asp Glu Val 
            500                 505                 510         


Leu His Ile Tyr Gln Met Gly Lys Tyr Phe Ala Ile Glu Lys Lys Arg 
        515                 520                 525             


Ser Trp Leu Ala Asp Tyr Asp Ile Asp Ser Phe Tyr Thr Asp Pro Glu 
    530                 535                 540                 


Lys Gly Tyr Leu Lys Phe Tyr Glu Asn Ala Tyr Glu Glu Ile Ile Gln 
545                 550                 555                 560 


Val Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Glu 
                565                 570                 575     


Asp Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala Asp Gly Trp 
            580                 585                 590         


Asp Lys Asn Lys Glu Ala Asp Asn Ser Thr Val Ile Leu Lys Lys Asp 
        595                 600                 605             


Gly Arg Tyr Tyr Leu Gly Leu Met Ala Arg Gly Arg Asn Lys Leu Phe 
    610                 615                 620                 


Asp Asp Arg Asn Leu Pro Lys Ile Leu Glu Gly Val Glu Asn Gly Lys 
625                 630                 635                 640 


Tyr Glu Lys Val Val Tyr Lys Tyr Phe Pro Asp Gln Ala Lys Met Phe 
                645                 650                 655     


Pro Lys Val Cys Phe Ser Thr Lys Gly Leu Glu Phe Phe Gln Pro Ser 
            660                 665                 670         


Glu Glu Val Ile Thr Ile Tyr Lys Asn Ser Glu Phe Lys Lys Gly Tyr 
        675                 680                 685             


Thr Phe Asn Val Arg Ser Met Gln Arg Leu Ile Asp Phe Tyr Lys Asp 
    690                 695                 700                 


Cys Leu Val Arg Tyr Glu Gly Trp Gln Cys Tyr Asp Phe Arg Asn Leu 
705                 710                 715                 720 


Arg Lys Thr Glu Asp Tyr Arg Lys Asn Ile Glu Glu Phe Phe Ser Asp 
                725                 730                 735     


Val Ala Met Asp Gly Tyr Lys Ile Ser Phe Gln Asp Val Ser Glu Ser 
            740                 745                 750         


Tyr Ile Lys Glu Lys Asn Gln Asn Gly Asp Leu Tyr Leu Phe Glu Ile 
        755                 760                 765             


Lys Asn Lys Asp Trp Asn Glu Gly Ala Asn Gly Lys Lys Asn Leu His 
    770                 775                 780                 


Thr Ile Tyr Phe Glu Ser Leu Phe Ser Ala Asp Asn Ile Ala Met Asn 
785                 790                 795                 800 


Phe Pro Val Lys Leu Asn Gly Gln Ala Glu Ile Phe Tyr Arg Pro Arg 
                805                 810                 815     


Thr Glu Gly Leu Glu Lys Glu Arg Ile Ile Thr Lys Lys Gly Asn Val 
            820                 825                 830         


Leu Glu Lys Gly Asp Lys Ala Phe His Lys Arg Arg Tyr Thr Glu Asn 
        835                 840                 845             


Lys Val Phe Phe His Val Pro Ile Thr Leu Asn Arg Thr Lys Lys Asn 
    850                 855                 860                 


Pro Phe Gln Phe Asn Ala Lys Ile Asn Asp Phe Leu Ala Lys Asn Ser 
865                 870                 875                 880 


Asp Ile Asn Val Ile Gly Val Asp Arg Gly Glu Lys Gln Leu Ala Tyr 
                885                 890                 895     


Phe Ser Val Ile Ser Gln Arg Gly Lys Ile Leu Asp Arg Gly Ser Leu 
            900                 905                 910         


Asn Val Ile Asn Gly Val Asn Tyr Ala Glu Lys Leu Glu Glu Lys Ala 
        915                 920                 925             


Arg Gly Arg Glu Gln Ala Arg Lys Asp Trp Gln Gln Ile Glu Gly Ile 
    930                 935                 940                 


Lys Asp Leu Lys Lys Gly Tyr Ile Ser Gln Val Val Arg Lys Leu Ala 
945                 950                 955                 960 


Asp Leu Ala Ile Gln Tyr Asn Ala Ile Ile Val Phe Glu Asp Leu Asn 
                965                 970                 975     


Met Arg Phe Lys Gln Ile Arg Gly Gly Ile Glu Lys Ser Val Tyr Gln 
            980                 985                 990         


Gln Leu Glu Lys Ala Leu Ile Asp  Lys Leu Thr Phe Leu  Val Glu Lys 
        995                 1000                 1005             


Glu Glu  Lys Asp Val Glu Lys  Ala Gly His Leu Leu  Lys Ala Tyr 
    1010                 1015                 1020             


Gln Leu  Ala Ala Pro Phe Glu  Thr Phe Gln Lys Met  Gly Lys Gln 
    1025                 1030                 1035             


Thr Gly  Ile Val Phe Tyr Thr  Gln Ala Ala Tyr Thr  Ser Arg Ile 
    1040                 1045                 1050             


Asp Pro  Val Thr Gly Trp Arg  Pro His Leu Tyr Leu  Lys Tyr Ser 
    1055                 1060                 1065             


Ser Ala  Glu Lys Ala Lys Ala  Asp Leu Leu Lys Phe  Lys Lys Ile 
    1070                 1075                 1080             


Lys Phe  Val Asp Gly Arg Phe  Glu Phe Thr Tyr Asp  Ile Lys Ser 
    1085                 1090                 1095             


Phe Arg  Glu Gln Lys Glu His  Pro Lys Ala Thr Val  Trp Thr Val 
    1100                 1105                 1110             


Cys Ser  Cys Val Glu Arg Phe  Arg Trp Asn Arg Tyr  Leu Asn Ser 
    1115                 1120                 1125             


Asn Lys  Gly Gly Tyr Asp His  Tyr Ser Asp Val Thr  Lys Phe Leu 
    1130                 1135                 1140             


Val Glu  Leu Phe Gln Glu Tyr  Gly Ile Asp Phe Glu  Arg Gly Asp 
    1145                 1150                 1155             


Ile Val  Gly Gln Ile Glu Val  Leu Glu Thr Lys Gly  Asn Glu Lys 
    1160                 1165                 1170             


Phe Phe  Lys Asn Phe Val Phe  Phe Phe Asn Leu Ile  Cys Gln Ile 
    1175                 1180                 1185             


Arg Asn  Thr Asn Ala Ser Glu  Leu Ala Lys Lys Asp  Gly Lys Asp 
    1190                 1195                 1200             


Asp Phe  Ile Leu Ser Pro Val  Glu Pro Phe Phe Asp  Ser Arg Asn 
    1205                 1210                 1215             


Ser Glu  Lys Phe Gly Glu Asp  Leu Pro Lys Asn Gly  Asp Asp Asn 
    1220                 1225                 1230             


Gly Ala  Phe Asn Ile Ala Arg  Lys Gly Leu Val Ile  Met Asp Lys 
    1235                 1240                 1245             


Ile Thr  Lys Phe Ala Asp Glu  Asn Gly Gly Cys Glu  Lys Met Lys 
    1250                 1255                 1260             


Trp Gly  Asp Leu Tyr Val Ser  Asn Val Glu Trp Asp  Asn Phe Val 
    1265                 1270                 1275             


Ala Asn  Lys 
    1280     


<210>  5
<211>  1137
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12q

<400>  5

Met Ile Asn Ile Asp Glu Leu Lys Asn Leu Tyr Lys Val Gln Lys Thr 
1               5                   10                  15      


Ile Thr Phe Glu Leu Lys Asn Lys Trp Glu Asn Lys Asn Asp Glu Asn 
            20                  25                  30          


Asp Arg Val Glu Phe Leu Lys Thr Gln Glu Trp Val Glu Ser Leu Phe 
        35                  40                  45              


Lys Val Asp Glu Glu Asn Phe Asp Glu Lys Glu Ser Ile Pro Asn Leu 
    50                  55                  60                  


Leu Asp Phe Gly Gln Lys Ile Ala Ser Leu Phe Tyr Lys Leu Ser Glu 
65                  70                  75                  80  


Asp Ile Ala Asn Asn Gln Ile Asp Thr Arg Val Leu Lys Val Ser Lys 
                85                  90                  95      


Phe Leu Leu Glu Glu Ile Asp Arg Asn Gln Tyr His Glu Lys Lys Asn 
            100                 105                 110         


Lys Pro Thr Lys Val Lys Glu Met Asn Pro Asn Thr Asn Lys Ser Tyr 
        115                 120                 125             


Ile Lys Glu Tyr Lys Leu Ser Asp Gln Asn Thr Leu Tyr Val Leu Leu 
    130                 135                 140                 


Lys Ile Met Glu Asp Glu Gly Arg Gly Leu Gln Lys Phe Leu Tyr Asp 
145                 150                 155                 160 


Lys Ala Asp Arg Leu Asn Leu Tyr Asn Gln Lys Val Arg Arg Asp Phe 
                165                 170                 175     


Ala Leu Lys Glu Ser Asn Glu Gln Gln Lys Phe Ser Gly Asn Ala Asn 
            180                 185                 190         


Tyr Tyr Gly Asn Ile Lys Leu Leu Ile Asp Ser Leu Glu Asp Ala Val 
        195                 200                 205             


Arg Ile Ile Gly Tyr Phe Thr Phe Asp Asp Gln Ala Glu Asn Ala Gln 
    210                 215                 220                 


Ile Asn Glu Phe Lys Ser Val Lys Gln Glu Met Asn Asn Asn Glu Ala 
225                 230                 235                 240 


Ser Tyr Gln Ala Leu Lys Asp Phe Ala Ile Asp Asn Ala Lys Lys Glu 
                245                 250                 255     


Ile Glu Leu Thr Thr Leu Asn His Arg Ala Val Asn Lys Asp Pro Lys 
            260                 265                 270         


Lys Ile Gln Glu Gln Ile Glu Glu Val Glu Asn Phe Glu Glu Asp Ile 
        275                 280                 285             


Asn Gln Leu Lys His Gln Ile Ser Ala Leu Asn Asp Lys Lys Phe Asp 
    290                 295                 300                 


Val Val Ser Arg Leu Lys His Ala Leu Ile Lys Met Leu Pro Glu Leu 
305                 310                 315                 320 


Asn Leu Leu Asp Ala Glu Ser Glu Gln Gly Arg Glu Val Gln Gln Ile 
                325                 330                 335     


Tyr Gln Asp Lys Lys Asn Gly Leu Glu Leu Asp Asp Phe Lys Phe Asn 
            340                 345                 350         


Leu Leu Lys His His Gln Trp Gln Lys Thr Ile Phe Lys Tyr Ile Lys 
        355                 360                 365             


Leu Glu Gly Leu Val Leu Pro Asp Leu Tyr Ala Glu Asn Lys Gln Asp 
    370                 375                 380                 


Lys Ile Lys Val Tyr Ile Glu Asn Tyr Arg Gln Ser Gly Glu Arg Ile 
385                 390                 395                 400 


Ser Lys Lys Ala Arg Glu Glu Leu Gly Lys Ile Asp Lys Arg Glu Glu 
                405                 410                 415     


Phe Asn Gly Asn Asp Glu Leu Lys Lys Ala Trp Tyr Glu Tyr Lys Asp 
            420                 425                 430         


Phe Cys Arg Asp Lys Arg Asn Lys Ser Val Glu Leu Gly Asn Lys Lys 
        435                 440                 445             


Ser Leu Tyr Asn Ala Ile Lys Arg Glu Val Leu Arg Gln Lys Met Cys 
    450                 455                 460                 


Asn His Phe Ala Val Leu Val Ser Asp Gly Glu Asp Thr Ser Pro Tyr 
465                 470                 475                 480 


Tyr Tyr Leu Ile Leu Ile Pro Asn Glu Asn Ser Asp Glu Met Asn Arg 
                485                 490                 495     


Thr Phe Lys Glu Leu Lys Ala Ser Glu Gly Asn Trp Lys Met Leu Asp 
            500                 505                 510         


Tyr Asn Arg Leu Thr Phe Lys Ala Leu Glu Lys Leu Ala Leu Leu Arg 
        515                 520                 525             


Ser Ser Thr Phe Glu Ile Ala Asp Gln Glu Leu Gln Glu Glu Ala Lys 
    530                 535                 540                 


Lys Ile Trp Glu Glu Tyr Lys Glu Lys Ala Tyr Lys Asp Phe Lys Asn 
545                 550                 555                 560 


Lys Lys Leu Leu Gln Gly Leu Ser Gly Arg Gln Arg Glu Glu Lys Lys 
                565                 570                 575     


Gln Glu Leu Gln Lys Glu Ser Leu Asn Arg Val Ile Asn Tyr Leu Ile 
            580                 585                 590         


Arg Cys Ile Gln Ser Leu Pro Asp Ser Gly Lys Tyr Asn Phe Asn Phe 
        595                 600                 605             


Lys Glu Pro His Gln Tyr Gln Ser Leu Glu Glu Phe Ala Glu Glu Ile 
    610                 615                 620                 


Asp Arg Gln Gly Tyr His Cys Ala Trp Lys Asn Val Ser Lys Asp Lys 
625                 630                 635                 640 


Leu Met Glu Leu Glu Ala Met Glu Lys Ile Lys Val Phe Lys Leu His 
                645                 650                 655     


Asn Lys Asp Phe Arg Lys Val Lys Leu Asn Asp Ser Lys His Asn Pro 
            660                 665                 670         


Asn Leu Phe Thr Leu Tyr Trp Leu Asp Ala Met Asn Leu Asp Lys Val 
        675                 680                 685             


Asn Val Arg Leu Leu Pro Glu Val Asp Leu Tyr Lys Arg Ala Lys Glu 
    690                 695                 700                 


Thr Gln Leu Lys Leu Phe Glu Arg Asp Val Lys Cys Asn Ile Asn Asn 
705                 710                 715                 720 


Gln Lys Ile Lys Ser Ile Lys Glu Lys Asn Arg Leu Phe Gln Asp Lys 
                725                 730                 735     


Leu Tyr Ala Ser Phe Lys Leu Glu Phe Tyr Pro Glu Asn Glu Gly Leu 
            740                 745                 750         


Gly Phe Glu Gln Val Asn Asp Lys Val Asn Asn Phe Cys Gly Ser Asp 
        755                 760                 765             


Thr Ala Tyr Tyr Leu Gly Leu Asp Arg Gly Glu Lys Glu Leu Val Thr 
    770                 775                 780                 


Phe Cys Leu Val Asp Ser Asp Gly Arg Leu Val Lys Asn Gly Asp Trp 
785                 790                 795                 800 


Thr Lys Phe Lys Glu Val Asn Tyr Ala Asp Lys Leu Lys Gln Phe Tyr 
                805                 810                 815     


Tyr Ser Lys Gly Glu Ile Glu Ser Thr Gln Gln Gln Leu Leu Glu Ala 
            820                 825                 830         


Arg Asp Asn Ile Lys Gln Ala Thr Asn Thr Glu Asp Lys Glu Ser Met 
        835                 840                 845             


Lys Leu Asn Tyr Lys Lys Leu Glu Leu Lys Leu Lys Gln Gln Asn Leu 
    850                 855                 860                 


Leu Ala Gln Glu Phe Ile Lys Lys Ala Tyr Cys Gly Tyr Leu Ile Asp 
865                 870                 875                 880 


Ser Ile Asn Glu Ile Leu Arg Glu Tyr Pro Asn Thr Tyr Leu Val Leu 
                885                 890                 895     


Glu Asp Leu Asp Ile Ala Gly Lys Ala Asp Pro Glu Ser Gly Met Thr 
            900                 905                 910         


Asn Lys Glu Gln Asn Leu Asn Lys Thr Met Gly Ala Ser Val Tyr Gln 
        915                 920                 925             


Ala Ile Glu Asn Ala Ile Val Asn Lys Phe Lys Tyr Arg Thr Val Lys 
    930                 935                 940                 


Leu Ser Asp Ile Lys Gly Leu Gln Thr Val Pro Asn Val Val Lys Val 
945                 950                 955                 960 


Glu Asp Leu Arg Glu Val Lys Glu Val Glu Asp Gly Glu His Lys Phe 
                965                 970                 975     


Gly Leu Ile Arg Ser Val Lys Ser Lys Asp Gln Ile Gly Asn Ile Leu 
            980                 985                 990         


Phe Val Asp Glu Gly Glu Thr Ser  Asn Thr Cys Pro Asn  Cys Gly Phe 
        995                 1000                 1005             


Asn Ser  Asp Trp Phe Lys Arg  Asp Val Asp Phe Asp  Leu Glu Ile 
    1010                 1015                 1020             


Val Ala  Thr Val Asn Gly Gln  Lys Asn Ala Val Ile  Glu Gln Asn 
    1025                 1030                 1035             


Asp Lys  Lys Tyr Cys Phe Pro  Gly Glu Ile Tyr Lys  Leu Glu Ile 
    1040                 1045                 1050             


Ile Asn  Lys Glu Tyr Glu Thr  Asn Lys Arg Asn Leu  Ala Met Ile 
    1055                 1060                 1065             


Phe Lys  Pro Arg Ala Lys Ala  Cys Arg Lys Phe Ile  Asn Asn Asn 
    1070                 1075                 1080             


Leu Asp  Lys Asn Asp Tyr Phe  Tyr Cys Pro Tyr Cys  Ala Phe Ser 
    1085                 1090                 1095             


Ser Lys  Asn Cys Asn Asn Pro  Lys Leu Gln Asn Gly  Asp Phe Val 
    1100                 1105                 1110             


Val Tyr  Ser Gly Asp Asp Val  Ala Ala Tyr Asn Val  Ala Ile Arg 
    1115                 1120                 1125             


Gly Ile  Asn Leu Leu Asn Asn  Ile Lys 
    1130                 1135         


<210>  6
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 Direct Repeat

<400>  6
gtttaaggcc ttgacaaaat ttctactgta gtagat                                 36


<210>  7
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  7
atctacaaaa gtagaaatct aatagggata ttcgag                                 36


<210>  8
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  8
atctacaaaa gtagaaatta aataggtcta tttgag                                 36


<210>  9
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas9.1 Direct Repeat

<400>  9
actgtagcaa gacgaagggc cggcgcaatc cgcagc                                 36


<210>  10
<211>  1031
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9.3

<400>  10

Met Ile Phe Gly Leu Asp Val Gly Thr Thr Ser Ile Gly Phe Ala Leu 
1               5                   10                  15      


Ile Ser Leu Asp Glu Asp Lys Glu Thr Gly Cys Ile Val His Ser Gly 
            20                  25                  30          


Cys Arg Val Phe Pro Glu Gly Val Thr Glu Asp Lys Lys Glu Ser Arg 
        35                  40                  45              


Asn Lys Ala Arg Arg Glu Ala Arg Leu Arg Arg Arg Gln Leu Arg Arg 
    50                  55                  60                  


Lys Lys Glu Asn Arg Lys Arg Leu Ala Gln Phe Leu His Glu Thr Ser 
65                  70                  75                  80  


Leu Leu Pro Val Phe Gly Ser Thr Glu Trp Lys Asn Leu Met Asp Asn 
                85                  90                  95      


Thr His Ser Asn Pro Tyr Glu Leu Arg Ser Ala Ala Leu Lys Lys Gln 
            100                 105                 110         


Leu Gln Pro Phe Glu Leu Gly Lys Val Ile Tyr His Leu Ala Lys His 
        115                 120                 125             


Arg Gly Phe Lys Ala Thr Lys Leu Asp Glu Leu Met Ala Glu Ser Asp 
    130                 135                 140                 


Glu Lys Lys Glu Leu Gly Val Val Lys Asp Gly Ile Lys Glu Leu Asp 
145                 150                 155                 160 


His Lys Leu Gly Asp Gln Thr Leu Gly Val Tyr Leu Ala Ser Ile Pro 
                165                 170                 175     


Pro Ser Glu Lys Lys Arg Gly Arg Tyr Leu Gly Arg Tyr Met Ile Gln 
            180                 185                 190         


Glu Glu Leu Glu Gln Ile Leu Glu Tyr Gln Lys His Tyr Asn Pro Glu 
        195                 200                 205             


Leu Ile Thr Ser Thr Phe Lys Lys His Leu Asn Ser Leu Ile Phe Ser 
    210                 215                 220                 


Gln Arg Pro Thr Phe Trp Arg Leu Asn Thr Leu Gly Thr Cys Ser Leu 
225                 230                 235                 240 


Glu Gln Asn Glu Ser Val Cys Pro Lys His Ser Trp Ile Gly Gln Gln 
                245                 250                 255     


Phe Ile Met Met Gln Lys Val Asn Asp Leu Arg Ile Val Glu Pro His 
            260                 265                 270         


Pro Arg His Leu Thr Met Glu Glu Arg Thr Gln Leu Ile Gln Gly Leu 
        275                 280                 285             


Cys Lys Gln Lys Ile Met Ser Phe Gly Gly Ile Arg Lys Leu Leu His 
    290                 295                 300                 


Leu Pro Lys Gly Thr Val Phe Asn Phe Glu Thr Tyr Gln Asp Lys Glu 
305                 310                 315                 320 


Asp Lys Arg Gly Leu Pro Gly Asn Ala Ile Glu Ala Ala Leu Ser Thr 
                325                 330                 335     


Ile Phe Gly Ser Glu Trp Lys His Leu Pro His Lys Asp Ala Ile Arg 
            340                 345                 350         


Ser Ser Leu Ser Asn Arg Ile Trp Ser Ile Ser Tyr Asn Arg Val Gly 
        355                 360                 365             


Asn Lys Arg Ile Glu Ile Arg Ala Asp Glu Ser Tyr Gln Asn Gln Arg 
    370                 375                 380                 


Gln Thr Val Lys Gln Glu Met Met Lys Asp Trp Asn Ile Ala Glu Asp 
385                 390                 395                 400 


Gln Ala Glu Gln Leu Val Gln Leu Pro Ile Pro Pro Gln Trp Leu Arg 
                405                 410                 415     


Phe Ser Glu Lys Ala Ile Gln Lys Leu Leu Pro Asp Leu Glu Ser Gly 
            420                 425                 430         


Val Pro Leu Gln Thr Ala Ile Lys Glu His Tyr Pro Glu Thr Leu Lys 
        435                 440                 445             


Ser Ser Glu Val Glu His Glu Leu Leu Pro Ser Ser Pro His Leu Val 
    450                 455                 460                 


Pro Glu Leu Arg Asn Pro Thr Val Asn Arg Ala Leu Asn Glu Leu Arg 
465                 470                 475                 480 


Lys Val Val Asn Asn Ile Ile Arg Ser Tyr Gly Lys Pro Asp Ile Ile 
                485                 490                 495     


Arg Ile Glu Leu Ala Arg Asp Leu Lys Leu Gly Lys Lys Lys Lys Leu 
            500                 505                 510         


Glu Ile Thr Lys Lys Asn Arg Gln Arg Glu Gln Glu Arg Lys Glu Ala 
        515                 520                 525             


Lys Asn Gln Leu Glu Lys Glu Gly Val Lys Pro Thr Gly Met Asn Ile 
    530                 535                 540                 


Glu Lys Phe Leu Leu Trp Gln Glu Ser Asp Gly Leu Asp Leu Tyr Thr 
545                 550                 555                 560 


Gly Gln Lys Ile Ser Phe Ala Ala Leu Phe Lys Gln Thr Glu Tyr Asp 
                565                 570                 575     


Ile Glu His Ile Ile Pro Arg Ser Arg Ser Phe Asn Asn Thr Phe Phe 
            580                 585                 590         


Asn Lys Thr Leu Ala His Asn Glu Ile Asn Arg Gln Lys Gly Asn Met 
        595                 600                 605             


Ile Pro Lys Glu Phe Phe Gly Asp Gly Glu Thr Trp His Ala Phe Val 
    610                 615                 620                 


Thr Arg Val Asn Gln Ser Lys Leu Pro Leu Glu Lys Lys Glu Lys Leu 
625                 630                 635                 640 


Leu Ile Pro His Tyr Asp Ala Ile Ala Ser Glu Glu Met Thr Glu Arg 
                645                 650                 655     


Gln Leu Arg Asp Thr Ala Tyr Ile Ala Thr Glu Ala Lys Thr Tyr Leu 
            660                 665                 670         


Gln Thr Leu Gly Ile Pro Val Gln Pro Thr Asn Gly Arg Ala Thr Ala 
        675                 680                 685             


Ser Leu Arg Arg Val Trp Gly Ile Asn Ser Ile Trp Ala Thr Glu Phe 
    690                 695                 700                 


Gly Leu Glu Glu Glu Ser Lys Lys Ala Ala Gly Glu Lys Ile Arg Asp 
705                 710                 715                 720 


Asp His Arg His His Ala Val Asp Ala Ala Val Val Ala Leu Thr Ser 
                725                 730                 735     


Pro Gly Arg Ile Lys Arg Leu Ser Thr Phe Tyr Gln Tyr Arg Lys Glu 
            740                 745                 750         


Met Lys Pro Asp Asp Phe Pro Leu Pro Trp Glu Thr Phe Arg Ala Asp 
        755                 760                 765             


Leu Ile Thr Ser Leu His Lys Ile Ile Ile Ser His Arg Val Gln Arg 
    770                 775                 780                 


Lys Ile Ser Gly Pro Leu His Glu Glu Thr Ala Tyr Gly Phe Thr Lys 
785                 790                 795                 800 


Lys Lys Ser Glu Thr Asp Pro Thr Ala Tyr Tyr Phe Val Thr Arg Lys 
                805                 810                 815     


Thr Leu Asp Lys Asp Phe Lys Pro Asn Lys Val Lys Asp Ile Val Asp 
            820                 825                 830         


Pro Ala Val Arg His Leu Ile Gly Glu His Leu Gln Lys Phe Asp Asn 
        835                 840                 845             


Asn Pro Ala Val Ala Phe Ala Pro Glu Asn Arg Pro His Met Pro Leu 
    850                 855                 860                 


Arg Lys Gly Gly Trp Gly Pro Pro Ile Lys Lys Val Arg Ile Gln Ile 
865                 870                 875                 880 


Ala Arg Asn Pro Gln Phe Met Val Ser Arg Gln Lys Asn Pro Ile Ser 
                885                 890                 895     


Tyr Tyr Asp Ser Gly Asp Asn His His Met Ala Ile Tyr Gly Thr His 
            900                 905                 910         


Leu Asp Asp Gly Thr Val Asp Pro Glu Thr Val Ser Phe Glu Val Val 
        915                 920                 925             


Ser Arg Phe Glu Val Asn Gln Arg Ala Ser Lys Asn Glu Pro Leu Val 
    930                 935                 940                 


Lys Pro Gln Asn Glu Asn Gly Val Pro Leu Leu Phe Thr Leu Val Lys 
945                 950                 955                 960 


Asn Asn Val Leu Ile Trp Asn Glu Pro Gly Glu Glu Glu Gln Met His 
                965                 970                 975     


Leu Val Arg Trp Thr Thr Ala Asn Lys Gly Arg Ile Phe His Lys Pro 
            980                 985                 990         


Leu Trp Met Ser Gly Thr Pro Pro  Ile Glu Ile Ser Ile  Ser Val Lys 
        995                 1000                 1005             


Asn Leu  Ile Ser Tyr Gly Gly  Arg Lys Val Ser Val  Asp Pro Ile 
    1010                 1015                 1020             


Gly Asn  Ile Phe Pro Cys Asn  Asp 
    1025                 1030     


<210>  11
<211>  1308
<212>  PRT
<213>  Unknown

<220>
<223>  Cas9.4

<400>  11

Met Lys Lys Ile Leu Gly Leu Asp Leu Gly Thr Asp Ser Ile Gly Trp 
1               5                   10                  15      


Thr Ile Val Gln Gln Asn Glu Glu Lys Lys Phe Lys Leu Ile Asp Lys 
            20                  25                  30          


Gly Val Arg Ile Phe Gln Lys Gly Val Gly Glu Glu Lys Asn Asn Glu 
        35                  40                  45              


Phe Ser Leu Ala Lys Glu Arg Thr Thr His Arg Asn Thr Arg Lys Lys 
    50                  55                  60                  


Tyr Arg Arg Thr Lys Gln Arg Lys Val Arg Leu Leu Arg Glu Leu Ile 
65                  70                  75                  80  


Lys His Gly Met Cys Pro Leu Ser Phe Asp Glu Leu Glu Leu Trp Ser 
                85                  90                  95      


Lys Tyr Arg Lys Gly Lys Pro Tyr Ile Tyr Pro Leu Ser Asn Lys Gly 
            100                 105                 110         


Phe Thr Gln Trp Leu Lys Leu Asn Pro Tyr Asp Leu Arg Glu Arg Ala 
        115                 120                 125             


Ile Lys Pro Asp Glu Lys Leu Thr Pro Leu Glu Leu Gly Arg Ile Phe 
    130                 135                 140                 


Tyr His Ile Thr Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Asp Asn 
145                 150                 155                 160 


Ser Glu Asp Ser Glu Gly Val Val Lys Thr Ser Ile Ser Gln Leu Arg 
                165                 170                 175     


Glu Glu Met Glu Gly Lys Thr Leu Gly Gln Phe Phe Asn Asn Glu Leu 
            180                 185                 190         


Lys Lys Gly Asn Lys Val Arg Lys Lys Tyr Thr Ala Arg Glu Asp Tyr 
        195                 200                 205             


His His Glu Phe Asn Glu Ile Cys Asn Ile Gln Lys Ile Asp Asn Lys 
    210                 215                 220                 


Thr Lys Ala Ala Leu Glu Arg Glu Ile Phe Phe Gln Arg Ala Leu Lys 
225                 230                 235                 240 


Ser Gln Arg His Leu Val Gly Lys Cys Thr Leu Glu Pro Lys Lys Pro 
                245                 250                 255     


Arg Cys Pro Leu Ser Ala Ile Pro Tyr Glu Glu Phe Arg Ala Leu Gln 
            260                 265                 270         


Phe Ile Asn Ser Ile Arg Ile Lys Asp Ala Glu Glu Asn Leu Met Pro 
        275                 280                 285             


Leu Thr Gln Lys Glu Arg Glu Val Ile Gln Ser Leu Phe Phe Arg Lys 
    290                 295                 300                 


Ser Lys Pro Ser Phe Pro Phe Asn Asp Ile Lys Lys Ile Leu Glu Lys 
305                 310                 315                 320 


His Asn Gly Gln Arg Leu Thr Phe Asn Tyr Pro Glu Lys Leu Gln Ile 
                325                 330                 335     


Ile Gly Ser Pro Thr Ile Ala Leu Leu Lys Ser Val Phe Gly Glu Glu 
            340                 345                 350         


Trp Ala Ser Leu Ser Val Ala Tyr Thr Lys Lys Asp Gly Thr Thr Gly 
        355                 360                 365             


Thr Ile Asn Ser Glu Asp Val Trp His Ala Leu Phe Glu Phe Glu His 
    370                 375                 380                 


Asn Asp Lys Leu Glu Asp Phe Leu Lys Gln Arg Leu Lys Leu Ser Asp 
385                 390                 395                 400 


Asp Asn Ile Gln Lys Leu Ile Lys Gly Asn Leu Lys Gln Gly Tyr Ala 
                405                 410                 415     


Ser Leu Ser Arg Lys Ala Ile Asn Asn Ile Leu Pro Phe Leu Lys Asp 
            420                 425                 430         


Gly His Ile Tyr Thr His Ala Val Phe Leu Ala Lys Ile Pro Glu Ile 
        435                 440                 445             


Ile Gly Arg Lys Gln Trp Leu His Ser Lys Asp Gln Ile Val Asn Trp 
    450                 455                 460                 


Phe Leu Lys Ser Ala Glu Glu Leu Pro Leu Lys Asn Arg Leu Cys Lys 
465                 470                 475                 480 


Ile Val Asn Asn Leu Ile Thr Glu Phe Asn Glu Thr Tyr Ala Asn Ala 
                485                 490                 495     


Asp Pro Lys Tyr Ile Leu Asp Asp Ser Asp Lys Lys Ser Ile Asn Arg 
            500                 505                 510         


Ser Leu Gln His Asp Phe Gly Pro Lys Thr Trp Asn Lys Phe Ser Ser 
        515                 520                 525             


Glu Lys Lys Asp Glu Leu Gln Lys Glu Thr Glu Arg Leu Phe Leu Ser 
    530                 535                 540                 


Gln Ile Asn Lys Gly Asn Ala Ser Ala Pro Tyr Ile Lys Pro Tyr Arg 
545                 550                 555                 560 


Gln Asp Glu Glu Leu Lys Gln Tyr Leu Ile Asp Asn Phe Asn Ile Lys 
                565                 570                 575     


Gln Glu Glu Ala Glu Arg Ile Tyr His Pro Ser Ala Ile Asp Ile Phe 
            580                 585                 590         


Asp Glu Ala Pro Tyr Asn Asp Asp Gly Ile Lys Leu Leu Gln Ser Pro 
        595                 600                 605             


Arg Thr Pro Ser Ala Arg Asn Pro Met Ala Met Arg Ala Leu His Glu 
    610                 615                 620                 


Leu Arg Tyr Leu Leu Asn Gln Leu Leu Ser Gln Arg Gly Ile Asp Glu 
625                 630                 635                 640 


His Thr Val Ile His Leu Glu Met Ser Arg Glu Leu Asn Asn Gln Asn 
                645                 650                 655     


Lys Arg Leu Ala Ile Gln Arg Tyr Gln Gln Ala Arg Asn Glu Glu His 
            660                 665                 670         


Gln Glu Tyr Ala Lys Glu Ile Lys Lys Ile Phe Lys Glu Gln Thr Gln 
        675                 680                 685             


Lys Glu Ile Glu Pro Thr Glu Ala Asp Ile Leu Lys Tyr Arg Leu Trp 
    690                 695                 700                 


Lys Glu Gln Glu His Asn Cys Leu Tyr Thr Gly Arg Lys Ile Gly Ile 
705                 710                 715                 720 


Ala Asp Phe Ile Gly Asp Asn Ser Asn Val Asp Ile Glu His Thr Trp 
                725                 730                 735     


Pro Arg Ser Lys Ser Phe Asp Asn Ser Thr Ala Asn Lys Thr Leu Cys 
            740                 745                 750         


Asp Ser His Tyr Asn Arg Asn Ile Lys Lys Asn Lys Ile Pro Tyr Asp 
        755                 760                 765             


Leu Pro Asn Phe Lys Glu Ser Ala Ile Ile Glu Gly Lys Gln Tyr Asp 
    770                 775                 780                 


Pro Ile Lys Ala Arg Leu Lys Asp Trp Glu Glu Lys Cys Asn His Leu 
785                 790                 795                 800 


Lys Glu Leu Ala Ala Lys Tyr Arg Tyr Asn Ala Lys Arg Ala Ser Thr 
                805                 810                 815     


Lys Glu Gln Lys Asp Lys Ala Leu Gln Asn Ala His Phe Tyr Gln Met 
            820                 825                 830         


His His Glu Tyr Trp Lys Asp Lys Ile Phe Arg Phe Thr Gly Lys Glu 
        835                 840                 845             


Ile Arg Asn Ser Phe Lys Asn Ser Gln Leu Val Asp Thr Gly Ile Ile 
    850                 855                 860                 


Asn Lys Tyr Ala Arg Ala Tyr Leu Gln Thr Val Phe Asn Lys Val Phe 
865                 870                 875                 880 


Thr Ile Lys Gly Thr Leu Thr Ala Asp Phe Arg Lys Ala Trp Gly Ile 
                885                 890                 895     


Gln Asn Pro Asp Thr Ser Lys Ser Arg Gln Arg His Thr His His Ala 
            900                 905                 910         


Ile Asp Ala Ala Val Val Ala Cys Leu Thr Arg Asp Arg Tyr Asp Phe 
        915                 920                 925             


Leu Thr Gln Trp Tyr Arg Ala Glu Glu Lys Gly Asn Glu Arg Lys Lys 
    930                 935                 940                 


His Ile Ile Gln Glu Arg Met Lys Pro Trp Thr Thr Phe Val Gln Asp 
945                 950                 955                 960 


Ile Lys Ala Phe Glu Asn Ser Ile Leu Val Ser His His Thr Arg Lys 
                965                 970                 975     


Thr Ser Ala Lys Gln Thr Arg Lys Arg Leu Arg Glu Asn Gly Lys Ile 
            980                 985                 990         


Val Lys Asp Pro Asn Gly Asn Pro  Ile Tyr Ser Lys Gly  Asp Thr Phe 
        995                 1000                 1005             


Arg Asn  Arg Leu His Lys Asp  Thr Phe Tyr Gly Ala  Ile Leu Arg 
    1010                 1015                 1020             


Pro Gln  Ile Asp Lys Glu Gly  Lys Thr Val Thr Asp  Glu Asn Gly 
    1025                 1030                 1035             


Asn Pro  Lys Leu Thr Thr Gln  Tyr Val Val Lys Lys  Pro Val Thr 
    1040                 1045                 1050             


Asp Leu  Lys Glu Thr Asp Ile  Lys Asn Ile Val Asp  Ser Lys Ile 
    1055                 1060                 1065             


Lys Ser  Leu Phe Glu Ser Lys  Lys Leu Asn Glu Ile  Gln Lys Glu 
    1070                 1075                 1080             


Gly Ile  Ser Ile Pro Pro Ser  Lys Pro Glu Gly Lys  Glu Thr Pro 
    1085                 1090                 1095             


Ile Lys  Ser Val Arg Leu Lys  Gln Pro Phe Asn Pro  Ile Pro Leu 
    1100                 1105                 1110             


Arg Glu  His Thr His Leu Ser  Gln Lys Pro His Lys  Gln Tyr Tyr 
    1115                 1120                 1125             


His Val  Gln Asn Glu Gly Asn  Phe Leu Met Ala Ile  Tyr Glu Glu 
    1130                 1135                 1140             


Thr Ser  Ala Ser Lys Lys Pro  Glu Lys Thr Phe Glu  Leu Ile Ser 
    1145                 1150                 1155             


Asn Leu  Gln Ala Ala Asp Tyr  Tyr Lys Ala Ser Asn  Lys Glu Asn 
    1160                 1165                 1170             


Arg Glu  Gln Tyr Pro Ile Val  Pro Glu Arg Lys Phe  Ile Thr Lys 
    1175                 1180                 1185             


Arg Asn  Lys Glu Ile Glu Leu  Pro Leu Lys Gln Ile  Ile Tyr Ile 
    1190                 1195                 1200             


Gly Gln  Met Val Met Leu Tyr  Glu Asn Ser Pro Glu  Glu Leu Lys 
    1205                 1210                 1215             


Ser Lys  Asn Glu Glu Glu Leu  Phe Lys Cys Leu Tyr  Lys Ile Val 
    1220                 1225                 1230             


Gly Ile  Thr Ser Met Thr Ile  Gln Ala Lys Tyr Glu  Tyr Gly Val 
    1235                 1240                 1245             


Phe Ile  Leu Lys His His Ala  Ile Ser Thr Pro Tyr  Ser Glu Leu 
    1250                 1255                 1260             


Lys Pro  Lys Asp Gly Asp Phe  Ser Trp Glu Gly Asn  Ile Glu Ala 
    1265                 1270                 1275             


Met Arg  Lys Gln Leu His Ser  Arg Ile Lys Val Val  Ile Glu Asn 
    1280                 1285                 1290             


Leu Asp  Phe Lys Ile Thr Pro  Thr Gly Lys Ile Glu  Trp Leu Phe 
    1295                 1300                 1305             


<210>  12
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q spacer

<400>  12
gcttggaaat atgtcttatt tatca                                             25


<210>  13
<211>  3765
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1

<400>  13
atgaaggtct cgacttggga ttcgtttaca aaccaatacc ccctaacgaa aactctacgc       60

ttcgaattaa agccagtcgg caaaacactg cagaaaattc aagatcgcaa cctgattaca      120

gaagacgaac aacgccaaaa agatttcaac aaagtcaaaa aaataatgga cggatactac      180

aagcaattca tagaagaatg cttggaaggt gccaagatac cgttaaaaaa attggaagaa      240

aacaacaacg cttacacgaa actgaaaaaa gacccttaca acaaaaaatt aagggaagaa      300

tacgcaaaac tccaaaaaca attaaggaaa ctaattcacg acgaaataaa taaaaaagaa      360

gaattcaaat acttgttcaa gaaagaattc atcaaaaaaa tattgccgga atggctcgaa      420

aaaaaaggga aaaaagagga actcaaagaa atcgaaaaat tcgataaatg ggttacctac      480

tttagcggtt tttttaacaa ccgcaaaaac gttttttcaa gcgatgaaat ttcgacgtca      540

atgatttaca ggatagtcaa cgacaaccta ccgaaattcc tagatgacgt ttcacgcttc      600

ggagaaataa ccagatacaa ggaatttgac gccaaccaaa tagaagaaaa ctttgaaagc      660

gagttgaacg gagagaaatt aaaagatttt ttcaacttga aaaacttcaa caactgcctt      720

aaccaagaag gaatagaaaa attcaactta atcataggag gcaaaagcga agaaggcaac      780

aataaaataa agggcttaaa cgaattagtc aacgaactcg cccaaaaaca agcggacaaa      840

aacgagcaaa aaaaggttag aaaattaaaa ctcgcgccgt tattcaagca aatcttaagt      900

gaccgcaaat cctcctcgtt cgcattcgaa aaattcgagg aaaatacgga ggtattcgat      960

gcaatagacg aattttacga taaaataagc ttggaaacac tcaaaaaaat agaagcgacc     1020

ctcgaaaagc tagaagaaaa agatttggaa ttagtttact tgaaaaacga tagatgccta     1080

acaggaattt cacaagaagt attcggggat cgggaaagag tacttcaagc cctaagggaa     1140

tacgcgaaaa ccgaactcgg cctcaaaacc gacaaaaaaa tagaaaaatg gatgaaaaaa     1200

ggcaggtatt caatccacga aatagagagc ggcctcaaaa aaatcggttc aaccggacac     1260

ccgatatgta attatttctc aaaactagaa gaaaaaaaga caaacttgat tcaagaaata     1320

aaaaaagcgc gcactgaata tgaaaaaata agtgacaaaa aaaagaaatt aactgctgaa     1380

agccaagagc ccaacgtcgc aagaataaag gcgttactgg actcaataat gcggctatac     1440

cacttcataa aacccctcaa catcaacttc aaaaacaaga aagaaaagga ttcagaggca     1500

cttgaaaccg ataacgattt ctataacgat ttcgacgaat cgtttgcgga actagggaat     1560

ataatcccac tatacaatca agtcagaaac tatgttacgc aaaaaccgtt cagcaccgaa     1620

aaattcaagt taaactttga aaatcccaaa ctcctaagcg gctgggacaa aaacaaggaa     1680

aaagactatt attctgttat attgagaaaa gaggagtcat actacttagc cattatgacc     1740

ccaaaacaaa aaaacgtttt tgacgaactg gaacggcttc cggctggaaa aaattatttt     1800

gaaaaaatag actacaaatt attgcctacc ccagaaaaaa atctacctag aatattattt     1860

gcaaaaaaaa acatttcatt ttacaagcca tcaaaagaaa tcgaagcgat tcgtaatcac     1920

tctgcccaca ccaagcatgg aaacccacaa aacgggttca aaaaaaggga tttccgatta     1980

agcgattgcc ataaaatgat tgacttttac aaaaagagca ttcaaaaaca ccccgaatgg     2040

aaagaatacg atttccaatt caaaaaaacg gaagattacg tcgacatatc agaattttat     2100

aaagaagtat ccgaccaagg ctataaaata gaattcaaaa aaataagcga aaaatatttg     2160

cttgacttgg tcgaagaagg aaaactttac ttattccaaa tttggaacaa ggacttttcg     2220

aagtattcgg aaggccgtaa aaacctgcac acaatttact ggaaagaact attctccaaa     2280

gaaaaccttt cagacataac ttacaaatta aacggcgaag ccgaaatatt ctaccgccca     2340

aagtcaatgg aaaggaaagt aactcaccca aaaaaccaaa aaatagaaaa caaagacccg     2400

attaaaggga aaaaattcag taaattcaaa tacgacttta taaaaaacaa aaggtacacc     2460

gaagaccgtt tcttcttcca ctgcccgata accttgaact tccaggcgcg cgatggcagc     2520

aaaacgatta acaagcgggt caacgaccac atacgcgaaa caaaagatga cattttcgtg     2580

ttaagcattg accgcgggga aaggcacttg gcgtactaca cgctattgaa ttcaaaagga     2640

gaaatccaag aacaaggctc tttcaacgta atctcggacg acaaagaaag aaaacgtgat     2700

taccacgaaa aactggatga acgcgaaaaa gaacgcgaca aagcaaggaa aagctggcag     2760

aaaatcgaga ccataaagaa attgaaggat ggctacctat cccaaatcgt acacaaaatc     2820

gctaaactcg caatagaaaa aaacgcgata atcgtcttgg aagacctgaa cttagacttc     2880

aagcgcggga gattaaaaat cgagaagcaa gtataccaaa agttcgagaa aaaactaata     2940

gacaaactca attacttggt tttcaaggaa agaaccgaaa aagaagccgg cggatcccta     3000

aacgcatacc aactaaccgg aaaatttgaa ggatttaaga aactcggaaa agaaacaggt     3060

ataatatact acgttcccgc ggcgtacacc tcgaagattt gcccgaaaac aggcttcgta     3120

aatctgttaa gacctaaatt caagaacata gaaaaagcta aggaattctt caaaaaattc     3180

aactacatca aatacgattc gagcgaaggc ttattcgaat tcaacttcga ctactccaaa     3240

ttcattaaaa acggaaaaaa agaaacaaaa ataattcaag acaattggtc ggtttactcg     3300

aacggaacga aactagtcgg cttcagaaac aagaataaaa acaattcatg ggatacaaag     3360

gaagtcaaac cgaacgaaaa actaaaaata ttgttcaaag aatacggggt ttccttccaa     3420

aaagacgaaa atattataag ccaaatagcc agccaaaaca aaaaagcttt ctttgaaaac     3480

ctcattaaaa tctttaaaac gattttaatg ttacgcaact caagaaaaga ccccgaagaa     3540

gattacgtac tttcctgcgt aaaagacgaa aacggcgaat tcttcgactc aagaaaagct     3600

aaagacaacg agcccaagga cgccgacgcg aacggcgctt accacatagg gttgaaagga     3660

ttaatgctct tggaaagaat aaaggccaac aaaggaaaga aaaaactcga tttactaatc     3720

agcaggaacg acttcatcaa cttcgcagtt gaacggagca agtaa                     3765


<210>  14
<211>  3846
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p

<400>  14
atgaaaaaat ctatttttga tcagtttgta aatcagtatg ctctttctaa aacgttgcgg       60

tttgaattga agccggtggg ggagacgggg aggatgcttg aggaggcgaa ggtttttgct      120

aaagatgaaa caatcaagaa aaaatatgag gcaaccaagc ctttttttaa taaattgcat      180

cgtgaatttg tagaggaggc tttaaatgag gtggaattag ctggtttgcc tgaatatttt      240

gaaatattta aatattggaa aaggtataaa aagaagtttg aaaaggattt gcagaagaaa      300

gaaaaagaat tgcggaaatc agttgtaggt ttttttaatg cacaggcaaa ggaatgggcg      360

aaaaaatatg aaactttggg tgtgaagaaa aaagatgtgg gacttttatt tgaagaaaat      420

gtttttgcta tattgaagga aaggtacgga aatgaggagg gatcacaaat tgttgatgaa      480

agtacaggaa aagatgtttc gatatttgat agttggaagg gctttacagg gtattttatt      540

aaattccagg aaactcgtaa gaatttttat aaggatgatg gcacggctac tgctttggct      600

acaaggatta ttgatcaaaa tttgaagcgt ttttgtgata atttactaat atttgaaagt      660

attagagata aaattgattt ttcagaggta gaacaaacta tgggaaactc tattgataag      720

gttttttcag taatttttta tagttcctgt ttacttcagg aaggaattga tttttataat      780

tgtgttttag gtggggagac tctgccaaat ggtgaaaaga gacagggaat aaatgagctt      840

attaatctct ataggcaaaa aactagtgag aaagtacctt ttttaaagtt gcttgataag      900

cagattttga gtgaaaaaga gaagtttatg gatgaaattg aaaatgatga ggctctcttg      960

gatactctta aaatatttag aaaatcggct gaagaaaaaa ccactttgtt aaaaaatatt     1020

tttggtgatt ttgttatgaa tcagggtaag tatgatttag cgcagattta tatttccaga     1080

gaatctttaa atactatttc acggaaatgg accagtgaaa cagatatatt tgaggattca     1140

ttatatgaag tgttaaagaa atcaaaaata gtttctgcct ctgtaaaaaa gaaagatgga     1200

gggtacgctt tccctgagtt tattgcgctt atttatgtga aaagtgctct tgaacaaatt     1260

cctactgaaa aattttggaa ggagcgatat tataaaaata ttggagatgt tttgaataaa     1320

gggtttttga atggtaagga aggtgtctgg ttacaatttt tattgatttt tgattttgaa     1380

tttaattctc tttttgaaag agaaataatt gatgaaaatg gagacaagaa agtggccgga     1440

tataatttgt ttgccaaggg ttttgatgat cttttgaata actttaaata tgatcaaaaa     1500

gctaaggttg ttattaagga ttttgcagat gaggttttac atatttatca gatgggaaaa     1560

tattttgcta ttgaaaagaa acgttcttgg ttggctgatt atgatattga ttcattttat     1620

actgatcctg aaaaaggtta tttgaagttt tatgaaaatg cgtatgaaga gattattcaa     1680

gtttataata aattgcgaaa ttacctaacg aagaaacctt atagtgagga taaatggaaa     1740

cttaattttg agaatccaac tttagctgat gggtgggaca aaaataaaga agctgataat     1800

tctacagtta ttttgaaaaa ggatggtcgc tattatttag ggttgatggc tcgcgggcga     1860

aataaacttt ttgatgatag aaatttacca aaaattttgg agggcgttga gaatgggaaa     1920

tatgagaaag ttgtatataa gtattttccg gatcaggcaa aaatgtttcc aaaagtttgt     1980

ttttcaacta aaggtttgga gtttttccaa ccttcggagg aagtcattac tatttacaaa     2040

aattctgaat tcaaaaaagg gtatactttt aatgtaagga gtatgcagag gcttattgat     2100

ttttataaag attgtcttgt tagatatgag gggtggcaat gttatgattt tagaaatttg     2160

agaaagacag aagattatcg gaagaatatt gaagagtttt tcagcgatgt tgctatggat     2220

gggtataaaa tatcctttca ggatgtctcg gaaagttata ttaaagagaa aaatcagaat     2280

ggggatttat atttatttga gataaaaaat aaagattgga atgaaggcgc aaatggaaag     2340

aaaaatttgc acactatata ttttgaatct cttttttcgg ctgataatat tgccatgaat     2400

tttcccgtta agttgaatgg acaagcggaa attttttatc ggccaagaac agaggggctg     2460

gagaaagaaa ggataatcac taaaaagggt aatgttttgg aaaaaggaga taaagctttt     2520

cataaaagaa ggtatacgga aaacaaagtt ttttttcatg ttccgattac acttaatcga     2580

acaaaaaaaa atccatttca atttaatgca aaaattaatg attttttggc taaaaattct     2640

gatataaatg ttattggggt cgatcgtggg gagaagcaat tagcatattt ttctgttatt     2700

tcacagagag gcaaaatttt ggataggggt agtttaaatg tgataaatgg agttaattat     2760

gcagagaaat tagaagaaaa agctagaggg cgtgagcagg cgcgtaagga ttggcagcag     2820

attgaaggta ttaaagattt aaagaaggga tatatttctc aggtagttag aaagctagcc     2880

gatttagcaa ttcagtataa tgcgattatt gtttttgaag atttgaacat gcggtttaag     2940

cagattcgtg gaggtattga aaaaagtgtt tatcagcagt tggagaaggc tttgattgat     3000

aaattaactt ttttggttga aaaggaagaa aaagatgtag aaaaggcagg tcatttgtta     3060

aaagcttacc agcttgctgc tccgtttgag acttttcaga aaatgggtaa acaaacgggg     3120

attgtttttt atacacaggc tgcatatact tcacgaattg atcctgttac aggttggcgg     3180

cctcacttgt atttgaaata ttccagtgcg gagaaggcaa aggcggattt attaaaattt     3240

aaaaagataa agtttgtgga tggccggttt gagtttactt atgatattaa gagttttcgt     3300

gaacaaaagg aacatccaaa ggcgactgtc tggacggtgt gttcttgcgt ggagagattt     3360

cgttggaata gatatttaaa tagcaataaa ggtggttatg accattacag tgatgtgacg     3420

aagttcttgg tagagctttt tcaagagtat gggattgatt ttgaaagagg ggatattgtc     3480

gggcaaattg aggttttgga aacgaaggga aatgaaaaat tttttaagaa tttcgttttt     3540

ttctttaatt tgatttgtca gataagaaat actaatgcgt cggagttggc aaaaaaagat     3600

ggaaaagatg attttattct ttcaccggtg gaaccgtttt ttgatagcag aaattcggag     3660

aagtttgggg aggatttgcc aaaaaatggg gatgataatg gggcatttaa tattgcgagg     3720

aaagggcttg ttattatgga taaaattaca aaatttgcag atgagaatgg tgggtgcgag     3780

aagatgaagt ggggagattt gtatgtttct aatgtggagt gggataattt tgtagctaat     3840

aaatga                                                                3846


<210>  15
<211>  3414
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q

<400>  15
atgataaata ttgacgaatt aaaaaattta tataaagttc aaaaaacaat tacttttgaa       60

ttaaaaaata aatgggaaaa taagaatgat gaaaatgata gagttgagtt tttaaagact      120

caagaatggg tggaatcttt attcaaagtt gatgaggaga attttgatga aaaggagtca      180

attccgaact tgttagattt cggccaaaag attgcgagtc ttttttataa gttgagtgaa      240

gatatcgcta ataatcaaat tgatacacgg gttttaaaag tgagcaagtt tttgttggag      300

gagatcgata gaaatcaata tcatgagaaa aaaaataaac caacaaaggt taaggagatg      360

aatccaaata caaataagag ttatattaag gagtataagt tatcagatca aaatacattg      420

tatgttctgt tgaagataat ggaagatgaa gggcggggtt tacaaaaatt tttatatgat      480

aaggcagaca gattaaattt atataatcag aaggtaagaa gagatttcgc tttaaaagaa      540

agtaacgaac agcagaagtt ttcgggtaac gctaattatt acggaaacat aaaattgttg      600

attgattcat tggaagacgc tgttcgtatt attggttatt tcacgtttga tgatcaagca      660

gaaaatgctc aaataaatga attcaagagc gttaagcagg aaatgaataa caatgaagct      720

tcgtatcagg ctttgaaaga ttttgctatt gataacgcaa aaaaagaaat tgaacttaca      780

actctaaatc atagggctgt taacaaggat ccaaaaaaga tacaagaaca gattgaagaa      840

gtggaaaatt ttgaagaaga tataaatcaa ttgaagcacc aaatttctgc gcttaatgat      900

aaaaaatttg atgtagtgtc aagattaaag catgcattaa ttaaaatgtt accggagttg      960

aatttgttag atgctgaaag cgagcaaggt agagaggttc agcaaatata tcaagataaa     1020

aagaatggtt tggaattaga cgattttaag ttcaatttgc ttaaacatca tcaatggcag     1080

aaaaccattt ttaaatacat taaattagag ggtttggttt tacctgattt atatgccgaa     1140

aacaaacaag ataagattaa agtgtatatt gaaaattatc gacaaagcgg agaaaggata     1200

agtaaaaagg cacgcgagga gttgggcaag atcgataaaa gagaggaatt taatggtaat     1260

gatgaactaa agaaagcgtg gtacgaatac aaagattttt gcagagacaa gcgtaataaa     1320

tccgtggaat tgggcaataa gaaatcactg tacaatgcca tcaagcgtga ggttttaagg     1380

cagaaaatgt gtaatcattt tgccgtattg gtgagtgatg gggaagatac atcgccttat     1440

tattatttga tattaattcc caatgaaaac agtgatgaaa tgaacaggac attcaaagag     1500

cttaaagcat ccgaaggaaa ttggaagatg ctcgattata acagattaac ttttaaagct     1560

ttggaaaaat tggcattatt gcgcagctct acatttgaaa ttgcagacca agaactacaa     1620

gaagaagcta aaaaaatttg ggaagaatat aaagaaaagg cgtataaaga ttttaagaat     1680

aaaaaattat tacaagggct atccggtcgc caaagagaag aaaaaaaaca agaattgcaa     1740

aaagaaagtt taaatcgagt tataaattat ttaattcgtt gcattcagtc gttgccggat     1800

agcggtaaat acaattttaa ttttaaagaa ccgcatcaat atcagagctt ggaagagttt     1860

gcggaagaaa ttgatagaca gggttatcat tgcgcttgga agaatgtaag caaagacaag     1920

cttatggagc tggaggcgat ggaaaaaatt aaagtattta aattgcataa taaggatttt     1980

agaaaagtta aacttaacga ttcgaaacac aatccgaatc tttttacttt atattggctt     2040

gacgcgatga atttggataa agtcaatgtt cgtttattgc ccgaggtgga tttatataaa     2100

agagccaaag aaacgcaact aaaattattc gaaagagatg taaagtgcaa tattaataat     2160

caaaaaataa aatcaattaa agaaaaaaat agattatttc aagataaact ttacgcttca     2220

ttcaagctgg aattttatcc agaaaacgaa ggtttgggtt ttgaacaagt caatgataaa     2280

gtgaataatt tttgcggaag tgatacagcg tattatttgg gtttggatag gggtgagaaa     2340

gaattggtta cgttttgctt ggttgattct gatgggcggt tggttaagaa cggagattgg     2400

acgaagttta aagaggttaa ctatgcggat aaattaaagc aattttatta ttcaaaaggt     2460

gaaatagaat ctactcaaca acaacttttg gaagctcgag acaatattaa acaagctact     2520

aacacggagg ataaagaatc gatgaaatta aactataaaa aattagagtt gaaactaaaa     2580

caacagaatt tgttagcgca ggagtttatt aaaaaagctt attgcggtta tttgatagat     2640

tcaataaatg aaatattacg ggaatatcca aatacgtatc ttgtattaga ggatttggat     2700

atagcaggta aagctgaccc cgaaagcggc atgaccaata aagaacaaaa tttaaataaa     2760

acaatgggtg ccagcgttta tcaagctatt gaaaatgcca tagtaaataa gtttaaatac     2820

cgtactgtta aattatccga tatcaaaggt ttgcaaactg taccgaatgt agtgaaggtg     2880

gaagatttgc gcgaagttaa ggaagtggaa gatggtgagc ataaatttgg tttgataaga     2940

tccgtgaaat caaaggatca aattggcaat attctgtttg tggatgaagg agaaacatct     3000

aatacttgcc cgaattgcgg atttaacagc gattggttta agcgggatgt tgattttgat     3060

ttggagattg tggctactgt aaacggtcag aaaaatgcgg ttatagaaca aaacgacaaa     3120

aagtactgtt ttcccggtga aatttataag ttagaaataa ttaataaaga atacgaaaca     3180

aataaacgga atttagccat gatttttaaa ccgcgcgcaa aagcttgtag aaaatttata     3240

aataataatt tggataagaa tgactatttt tattgcccgt attgcgcttt ttctagcaag     3300

aactgcaata atccaaaatt gcaaaacggt gattttgtgg tatattcggg tgatgatgtg     3360

gcggcataca atgtagcgat cagaggtatt aaccttttaa acaatataaa atag           3414


<210>  16
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas12a.1 codon optimized version

<400>  16
atggggtcaa gtcatcacca ccaccaccac tcaagtggac tagtaccccg tggcagcatg       60

aaagttagca cctgggatag cttcaccaac cagtacccgc tgaccaagac cctgcgtttt      120

gagctgaagc cggtgggtaa aaccctgcag aagatccaag accgtaacct gattaccgag      180

gacgaacagc gtcaaaagga tttcaacaag gttaagaaaa tcatggatgg ttactacaag      240

cagttcatcg aggaatgcct ggaaggcgcg aagatcccgc tgaagaaact ggaggaaaac      300

aacaacgcgt acaccaaact gaagaaagac ccgtataaca agaaactgcg tgaggaatac      360

gcgaagctgc agaaacaact gcgtaaactg atccacgatg agattaacaa gaaagaggaa      420

ttcaagtacc tgtttaagaa agaattcatc aagaaaattc tgccggaatg gctggagaag      480

aaaggtaaga aagaggaact gaaagagatc gaaaagttcg acaaatgggt gacctacttt      540

agcggcttct ttaacaaccg taagaacgtt ttcagcagcg acgagattag caccagcatg      600

atctatcgta ttgtgaacga taacctgccg aaattcctgg acgatgttag ccgttttggt      660

gaaattaccc gttacaagga gttcgacgcg aaccagatcg aggaaaactt tgagagcgaa      720

ctgaacggtg aaaaactgaa ggatttcttt aacctgaaaa acttcaacaa ctgcctgaac      780

caagaaggca ttgagaaatt taacctgatc attggtggca agagcgagga aggtaataac      840

aaaatcaagg gcctgaacga actggtgaac gagctggcgc aaaaacaagc ggacaagaac      900

gagcagaaga aagttcgtaa actgaagctg gcgccgctgt tcaaacaaat cctgagcgat      960

cgtaagagca gcagctttgc gttcgaaaaa tttgaggaaa acaccgaggt gttcgacgcg     1020

atcgatgaat tttatgacaa gattagcctg gagaccctga agaaaatcga agcgaccctg     1080

gagaaactgg aggaaaagga cctggaactg gtttacctga aaaacgatcg ttgcctgacc     1140

ggtatcagcc aggaagtgtt cggcgaccgt gagcgtgttc tgcaagcgct gcgtgaatac     1200

gcgaaaaccg agctgggtct gaagaccgat aagaaaatcg agaagtggat gaagaaaggt     1260

cgttatagca tccacgagat tgaaagcggc ctgaagaaaa tcggtagcac cggccacccg     1320

atttgcaact acttcagcaa actggaggaa aagaaaacca acctgatcca ggaaattaag     1380

aaagcgcgta ccgagtatga aaagatcagc gacaagaaaa agaaactgac cgcggaaagc     1440

caagagccga acgtggcgcg tatcaaagcg ctgctggata gcattatgcg tctgtatcac     1500

ttcatcaagc cgctgaacat caacttcaag aacaagaaag agaaggacag cgaagcgctg     1560

gagaccgaca acgattttta caacgacttc gatgaaagct ttgcggagct gggcaacatc     1620

attccgctgt acaaccaagt gcgtaactat gttacccaaa aaccgttcag caccgagaaa     1680

ttcaagctga actttgaaaa cccgaagctg ctgagcggtt gggacaaaaa caaggaaaaa     1740

gattactata gcgtgattct gcgtaaagag gaaagctact atctggcgat catgaccccg     1800

aagcagaaaa acgttttcga cgagctggaa cgtctgccgg cgggcaaaaa ttacttcgag     1860

aagatcgatt acaagctgct gccgaccccg gaaaagaacc tgccgcgtat cctgttcgcg     1920

aagaaaaaca ttagctttta caagccgagc aaagagatcg aagcgattcg taaccacagc     1980

gcgcacacca aacacggtaa cccgcagaac ggcttcaaga aacgtgactt tcgtctgagc     2040

gattgccaca agatgatcga cttctacaag aaaagcattc agaaacaccc ggaatggaag     2100

gagtatgatt ttcaattcaa gaaaaccgag gactacgtgg atatcagcga attctataaa     2160

gaggtttctg accagggtta caagatcgaa ttcaagaaaa ttagcgagaa atacctgctg     2220

gacctggtgg aggaaggtaa actgtacctg ttccaaatct ggaacaagga tttcagcaag     2280

tacagcgaag gccgtaaaaa cctgcacacc atctattgga aagaactgtt cagcaaggag     2340

aacctgagcg atattaccta taagctgaac ggcgaggcgg aaatctttta ccgtccgaaa     2400

agcatggagc gtaaggttac ccacccgaag aaccagaaaa tcgaaaacaa agacccgatc     2460

aagggtaaga aattcagcaa gttcaagtat gacttcatca agaacaagcg ttacaccgag     2520

gatcgtttct ttttccactg cccgatcacc ctgaactttc aagcgcgtga cggcagcaaa     2580

accatcaaca agcgtgtgaa cgatcacatt cgtgagacca aagacgatat cttcgttctg     2640

agcattgatc gtggtgaacg tcacctggcg tactataccc tgctgaacag caagggtgaa     2700

attcaggagc aaggcagctt taacgtgatc agcgacgata aggagcgtaa acgtgactat     2760

cacgaaaaac tggatgagcg tgaaaaggag cgtgacaagg cgcgtaaaag ctggcagaaa     2820

atcgagacca ttaagaaact gaaggatggc tacctgagcc aaatcgtgca caagattgcg     2880

aaactggcga tcgagaaaaa cgcgatcatt gttctggaag acctgaacct ggatttcaag     2940

cgtggtcgtc tgaagattga gaaacaggtg taccaaaaat tcgaaaagaa actgatcgac     3000

aagctgaact atctggtttt taaagaacgt accgaaaaag aggcgggtgg tagcctgaac     3060

gcgtatcagc tgaccggtaa attcgagggc tttaagaaac tgggcaagga aaccggcatc     3120

atttactatg tgccggcggc gtacaccagc aaaatctgcc cgaagaccgg cttcgttaac     3180

ctgctgcgtc cgaagttcaa gaacatcgaa aaggcgaagg agtttttcaa gaagttcaac     3240

tacatcaagt acgacagcag cgaaggtctg tttgagttca acttcgatta cagcaagttc     3300

atcaagaacg gcaagaaaga gaccaaaatc attcaggaca actggagcgt gtatagcaac     3360

ggtaccaagc tggttggctt ccgtaacaag aacaaaaaca acagctggga taccaaggaa     3420

gtgaaaccga acgagaagct gaaaattctg ttcaaagagt acggtgttag ctttcaaaag     3480

gacgaaaaca tcattagcca gatcgcgagc caaaacaaga aagcgttttt cgagaacctg     3540

atcaagattt tcaaaaccat tctgatgctg cgtaacagcc gtaaagaccc ggaggaagat     3600

tacgtgctga gctgcgttaa ggacgaaaac ggcgagtttt tcgacagccg taaggcgaaa     3660

gataacgagc cgaaagacgc ggatgcgaac ggcgcgtacc acattggtct gaagggcctg     3720

atgctgctgg aacgtatcaa ggcgaacaaa ggtaagaaaa agctggacct gctgatcagc     3780

cgtaacgatt tcattaactt tgcggttgag cgtagcaagt aa                        3822


<210>  17
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas12p codon optimized

<400>  17
atgggatcaa gtcatcacca ccaccaccac tcaagtggac tagtacccag gggaagcatg       60

aagaagagca ttttcgatca gttcgttaac cagtacgcgc tgagcaagac cctgcgtttc      120

gagctgaaac cggtgggtga aaccggccgt atgctggagg aagcgaaggt tttcgcgaag      180

gatgaaacca ttaagaaaaa gtacgaagcg accaagccgt tctttaacaa actgcaccgt      240

gaattcgtgg aggaagcgct gaacgaggtt gaactggcgg gcctgccgga gtacttcgaa      300

atcttcaagt actggaagcg ttacaaaaag aaattcgaga aggacctgca gaagaaagag      360

aaggaactgc gtaaaagcgt ggttggtttc tttaacgcgc aagcgaagga gtgggcgaag      420

aaatatgaaa ccctgggcgt gaagaaaaag gatgttggtc tgctgttcga ggaaaacgtg      480

tttgcgattc tgaaagaacg ttacggtaac gaggaaggca gccagattgt ggacgagagc      540

accggcaagg atgttagcat cttcgacagc tggaagggtt ttaccggcta tttcatcaaa      600

tttcaggaaa cccgtaagaa cttctacaaa gatgatggta ccgcgaccgc gctggcgacc      660

cgtatcattg atcaaaacct gaaacgtttc tgcgacaacc tgctgatctt tgagagcatt      720

cgtgataaga tcgacttcag cgaggttgaa cagaccatgg gcaacagcat cgataaggtg      780

ttcagcgtta tcttttatag cagctgcctg ctgcaagaag gtatcgactt ttacaactgc      840

gtgctgggtg gtgaaaccct gccgaacggt gaaaagcgtc agggcattaa cgaactgatc      900

aacctgtacc gtcaaaagac cagcgagaaa gttccgttcc tgaagctgct ggacaaacag      960

attctgagcg agaaggaaaa atttatggat gagatcgaaa acgacgaggc gctgctggat     1020

accctgaaga ttttccgtaa aagcgcggag gaaaagacca ccctgctgaa aaacatcttc     1080

ggcgattttg tgatgaacca gggtaaatat gacctggcgc aaatctacat tagccgtgaa     1140

agcctgaaca ccattagccg taagtggacc agcgaaaccg atatcttcga agacagcctg     1200

tacgaggtgc tgaaaaagag caaaatcgtg agcgcgagcg ttaaaaagaa agacggtggc     1260

tacgcgttcc cggagtttat cgcgctgatt tatgttaaaa gcgcgctgga acagattccg     1320

accgagaagt tctggaaaga acgttactat aagaacatcg gcgatgtgct gaacaagggt     1380

ttcctgaacg gtaaagaagg cgtttggctg caatttctgc tgatctttga cttcgaattt     1440

aacagcctgt tcgagcgtga aatcattgat gagaacggcg acaagaaagt ggcgggttat     1500

aacctgttcg cgaagggttt tgacgatctg ctgaacaact tcaaatacga ccagaaggcg     1560

aaagtggtta ttaaggattt tgcggacgaa gttctgcaca tttatcaaat gggcaaatac     1620

ttcgcgatcg agaagaaacg tagctggctg gcggactatg atattgacag cttctacacc     1680

gatccggaga agggttacct gaaattttat gaaaacgcgt acgaggaaat cattcaggtt     1740

tataacaagc tgcgtaacta cctgaccaag aaaccgtata gcgaggacaa gtggaaactg     1800

aacttcgaaa acccgaccct ggcggatggt tgggacaaga acaaagaggc ggataacagc     1860

accgtgattc tgaagaaaga cggtcgttac tatctgggcc tgatggcgcg tggtcgtaac     1920

aagctgttcg acgatcgtaa cctgccgaaa atcctggagg gtgttgaaaa cggcaagtac     1980

gaaaaggtgg tttacaagta cttcccggat caggcgaaga tgttcccgaa agtgtgcttt     2040

agcaccaaag gcctggaatt ctttcaaccg agcgaggaag ttatcaccat ttacaagaac     2100

agcgagttca agaaaggtta tacctttaac gtgcgtagca tgcagcgtct gattgatttc     2160

tataaagact gcctggttcg ttacgaaggt tggcaatgct atgattttcg taacctgcgt     2220

aagaccgagg actaccgtaa aaacatcgag gaattcttta gcgatgtggc gatggacggc     2280

tacaagatta gcttccagga cgttagcgag agctatatca aggagaagaa ccaaaacggt     2340

gatctgtacc tgtttgagat caagaacaaa gactggaacg aaggtgcgaa cggcaagaaa     2400

aacctgcaca ccatttattt cgagagcctg tttagcgcgg ataacatcgc gatgaacttc     2460

ccggtgaaac tgaacggcca ggcggagatc ttttaccgtc cgcgtaccga aggtctggag     2520

aaggaacgta tcattaccaa gaaaggcaac gttctggaaa agggtgacaa agcgttccac     2580

aagcgtcgtt acaccgagaa caaagtgttc tttcacgttc cgattaccct gaaccgtacc     2640

aagaaaaacc cgttccaatt taacgcgaag atcaacgact tcctggcgaa aaacagcgat     2700

atcaacgtga ttggtgttga ccgtggcgag aaacagctgg cgtattttag cgtgattagc     2760

caacgtggca agatcctgga ccgtggtagc ctgaacgtga tcaacggcgt taactacgcg     2820

gagaagctgg aggaaaaagc gcgtggtcgt gaacaggcgc gtaaggattg gcagcaaatc     2880

gagggcatta aagacctgaa gaaaggttat attagccagg tggttcgtaa actggcggat     2940

ctggcgatcc aatacaacgc gatcattgtg ttcgaggacc tgaacatgcg ttttaagcaa     3000

attcgtggtg gcatcgagaa aagcgtttat cagcaactgg aaaaggcgct gatcgataaa     3060

ctgaccttcc tggtggagaa ggaagaaaag gacgttgaaa aggcgggtca cctgctgaaa     3120

gcgtaccagc tggcggcgcc gttcgaaacc tttcagaaga tgggtaaaca aaccggcatt     3180

gtgttttata cccaagcggc gtacaccagc cgtatcgatc cggttaccgg ctggcgtccg     3240

cacctgtacc tgaaatatag cagcgcggaa aaggcgaaag cggacctgct gaagttcaag     3300

aaaattaagt tcgtggatgg tcgtttcgag tttacctacg acatcaagag cttccgtgag     3360

cagaaggaac acccgaaagc gaccgtgtgg accgtttgca gctgcgttga gcgttttcgt     3420

tggaaccgtt atctgaacag caacaaaggt ggctacgatc actatagcga cgtgaccaag     3480

ttcctggttg agctgtttca ggaatacggc atcgacttcg aacgtggtga tattgtgggc     3540

caaatcgagg ttctggaaac caagggtaac gagaagttct ttaagaactt cgtgttcttt     3600

ttcaacctga tctgccagat tcgtaacacc aacgcgagcg aactggcgaa gaaagacggc     3660

aaggacgatt tcattctgag cccggttgag ccgtttttcg atagccgtaa cagcgagaag     3720

ttcggcgaag acctgccgaa aaacggtgac gataacggcg cgtttaacat cgcgcgtaaa     3780

ggtctggtta ttatggataa gatcaccaaa ttcgcggacg agaacggtgg ctgcgaaaag     3840

atgaaatggg gtgacctgta tgtgagcaat gtggagtggg ataactttgt ggcgaataaa     3900

taa                                                                   3903


<210>  18
<211>  3471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas12q codon optimized

<400>  18
atggggtcct cccatcatca ccaccaccac tcttcaggct tggtaccgcg tggttccatg       60

atcaacatag acgaattgaa aaatttatat aaggtgcaaa agaccatcac tttcgaactt      120

aagaacaagt gggagaacaa aaatgatgag aacgacagag tagagttctt gaagactcag      180

gagtgggtcg aaagcctttt caaggtcgat gaagagaact ttgatgagaa agagtctatc      240

cctaacttgt tagacttcgg acagaagatt gcgtccttgt tttacaagct gagcgaggac      300

atagcgaaca accaaattga tacgcgggta ttgaaagtct cgaaattcct tttagaggaa      360

attgatagaa atcaatacca cgagaaaaaa aacaagccca caaaggtaaa agaaatgaat      420

cccaacacaa acaaaagtta tataaaagaa tataagctgt ccgaccaaaa cacactgtac      480

gtgttattaa agataatgga agatgaaggt cggggattac aaaaattttt gtacgataaa      540

gcggaccggt taaacctgta caatcaaaaa gttcggagag acttcgcctt aaaggaatca      600

aatgagcaac aaaaattctc tggaaatgcc aactactatg ggaatataaa gctgcttata      660

gatagcttag aagatgcagt ccggatcatt gggtatttca ctttcgacga tcaagcagaa      720

aacgcacaaa tcaatgaatt taagtccgtt aaacaggaaa tgaataataa tgaagcgtct      780

taccaagcac tgaaagactt cgctattgat aacgcaaaaa aagagataga attgacgacg      840

ttgaaccacc gggcggtcaa caaggatcca aaaaagattc aagaacagat tgaggaagtc      900

gaaaatttcg aagaagatat taaccagtta aagcatcaga tatcagcctt gaatgataag      960

aagtttgacg tggttagcag attaaagcac gctcttataa aaatgttacc agaactgaat     1020

cttttggatg ctgagtcgga acagggccgt gaagtccagc agatatatca agacaaaaaa     1080

aacgggttgg agcttgatga ctttaaattt aaccttttaa aacatcatca atggcaaaaa     1140

acgatcttca agtatattaa gcttgagggc ttagttctgc cagaccttta cgcggaaaac     1200

aaacaagata aaatcaaggt ttatattgag aattatagac agagtggtga gcgtatttct     1260

aagaaggcga gagaggaatt aggaaaaatc gataaacgcg aagagttcaa tggaaatgac     1320

gaacttaaga aggcatggta tgagtataag gacttctgta gagacaaacg taataagagc     1380

gtggaacttg gcaataagaa gtcgctgtac aatgccataa agcgcgaagt tttgcggcaa     1440

aaaatgtgca accatttcgc tgtgctggtg tccgacggtg aagatacttc cccttattat     1500

tatctgatat taatcccgaa cgagaactcc gatgaaatga atagaacgtt caaggaattg     1560

aaggcctccg aggggaattg gaagatgttg gattacaatc gtctgacctt caaagccttg     1620

gagaaattgg ccctgttacg gtcgtctacc ttcgagatag cggatcagga actgcaagaa     1680

gaggcaaaaa agatctggga ggagtacaag gaaaaggcgt acaaagactt caaaaacaaa     1740

aagttattac agggtttatc gggaagacag cgggaggaga aaaagcaaga attgcaaaag     1800

gagagcctga atagagtaat caattacttg atcagatgca ttcagtcatt gcccgacagc     1860

ggaaaataca actttaactt taaagagcct catcaatacc aatcgcttga agagtttgcc     1920

gaggagattg atcggcaagg ttatcactgt gcttggaaaa acgtttctaa agataaactg     1980

atggaattgg aagcgatgga aaagattaag gttttcaaac ttcataacaa agactttcgc     2040

aaggtaaaac tgaacgactc caagcacaac cctaatcttt ttactttgta ctggttagac     2100

gccatgaatt tggataaggt taacgtccgc ctgttaccgg aagttgacct ttacaagaga     2160

gctaaggaaa cacagctgaa attgttcgaa cgtgatgtga aatgcaatat caataaccaa     2220

aagattaaat ctatcaagga gaagaataga ctgtttcagg acaagttgta tgctagtttt     2280

aagttagagt tttatccaga aaacgaagga ttaggtttcg agcaggtaaa tgacaaggtc     2340

aataacttct gcggtagcga tacggcctat tatcttgggc ttgatcgtgg agagaaagag     2400

cttgttacat tctgcctggt ggactctgat ggccgcctgg taaaaaacgg agactggacc     2460

aagtttaaag aggtgaacta tgccgacaaa ctgaagcaat tctactactc aaaaggcgaa     2520

atagagagta cccaacaaca gctgttagaa gcccgggaca atattaaaca agcgaccaac     2580

acggaagata aggagtccat gaaactgaat tataagaaac tggaactgaa gttaaaacaa     2640

cagaatttgc tggcgcaaga attcataaaa aaagcgtact gcggctacct tatcgatagc     2700

attaatgaga ttctgagaga atatccaaat acttatcttg tcttagagga tttggatatc     2760

gcgggtaaag cggatccaga gtcggggatg actaataaag agcagaactt aaacaaaacg     2820

atgggggctt cagtatacca ggccattgag aatgcgatcg taaataaatt caaatatcgc     2880

accgtgaaat tgtccgatat caagggcctt cagactgtac ctaatgtagt gaaggtcgaa     2940

gacttacggg aagtgaaaga ggttgaagat ggggaacaca agttcgggtt aataagatca     3000

gttaagagca aggatcaaat cggtaacata ctttttgtcg acgaggggga gaccagtaac     3060

acttgtccga attgcggttt taatagtgat tggtttaaac gcgatgttga ttttgactta     3120

gaaatagtcg ctactgtaaa cgggcaaaag aatgccgtga ttgagcaaaa tgacaaaaaa     3180

tactgtttcc cgggcgaaat atataaattg gaaatcatta ataaagagta cgaaacaaac     3240

aagcgtaatc ttgccatgat ttttaaacct cgggccaaag cgtgccgtaa atttatcaat     3300

aataatttag ataagaacga ttatttctat tgtccctact gcgccttctc gtcgaagaat     3360

tgtaacaacc cgaaactgca gaacggcgat ttcgtggtat attcaggaga cgatgttgct     3420

gcttacaatg ttgctatcag aggaattaac ctgctgaaca atattaaata g              3471


<210>  19
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 repeat

<400>  19
gtttaaggcc ttgacaaaat ttctactgta gtagat                                 36


<210>  20
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p repeat

<400>  20
ctcgaatatc cctattagat ttctactttt gtagat                                 36


<210>  21
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q repeat

<400>  21
atctacaaaa gtagaaatta aataggtcta tttgag                                 36


<210>  22
<211>  30
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  22
cgtcgtattg agtgctagta ctggtttgag                                        30


<210>  23
<211>  32
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  23
attaaattac ataatgagcc aacacggcga cc                                     32


<210>  24
<211>  33
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q spacer

<400>  24
ctagctcctc tacgtcttta ttttcaccct cat                                    33


<210>  25
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 - Cas12p target

<400>  25
gtggcagctc aaaaattggc tacaaaac                                          28


<210>  26
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p direct repeat

<400>  26
ctcgaatatc cctattagat ttctactttt gtagat                                 36


<210>  27
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q direct repeat

<400>  27
ctcaaataga cctatttaat ttctactttt gtagat                                 36


<210>  28
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 Direct Repeat

<400>  28
gtttaaggcc ttgacaaaat ttccactgta gtggat                                 36


<210>  29
<211>  37
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 Direct Repeat

<400>  29
ggtttaaggc cttgacaaaa tttctcctgt aggagat                                37


<210>  30
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 Direct Repeat

<400>  30
gtttaaggcc ttgacaaaat ttcccctgta ggggat                                 36


<210>  31
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  31
atctacaaaa gtagaagtct aatagggaca ttcgag                                 36


<210>  32
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  32
atctacaaaa gtagaaagct aatagggcta ttcgag                                 36


<210>  33
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  33
atctacaaaa gtagaaggct aatagggcca ttcgag                                 36


<210>  34
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  34
ctcgaatatc cctattagat ttcgactttt gtcgat                                 36


<210>  35
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  35
ctcgaatatc cctattagat ttctcctttt ggagat                                 36


<210>  36
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p Direct Repeat

<400>  36
ctcgaatatc cctattagat ttcggctttt gccgat                                 36


<210>  37
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  37
atctacaaaa gtagaaattg aataggtcta ttcgag                                 36


<210>  38
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  38
atctacaaaa gtagaaatta aagaggtctc tttgag                                 36


<210>  39
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  39
atctacaaaa gtagaaattg ggtaggtcta cccgag                                 36


<210>  40
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  40
ctcaaataga cctatttaat ttccactttt gtggat                                 36


<210>  41
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  41
ctcaaataga cctatttaat ttctcctttt ggagat                                 36


<210>  42
<211>  36
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12q Direct Repeat

<400>  42
ctcaaataga cctatttaat ttcccctttt ggggat                                 36


<210>  43
<211>  487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KPC gB template 1 sequence

<400>  43
ttcaagggct ttcttgctgc cgctgtgctg gctcgcagcc agcagcaggc cggcttgctg       60

gacacaccca tccgttacgg caaaaatgcg ctggttccgt ggtcacccat ctcggaaaaa      120

tatctgacaa caggcatgac ggtggcggag ctgtccgcgg ccgccgtgca atacagtgat      180

aacgccgccg ccaatttgtt gctgaaggag ttgggcggcc cggccgggct gacggccttc      240

atgcgctcta tcggcgatac cacgttccgt ctggaccgct gggagctgga gctgaactcc      300

gccatcccag gcgatgcgcg cgatacctca tcgccgcgcg ccgtgacgga aagcttacaa      360

aaactgacac tgggctctgc actggctgcg ccgcagcggc agcagtttgt tgattggcta      420

aagggaaaca cgaccggcaa ccaccgcatc cgcgcggcgg tgccggcaga ctgggcagtc      480

ggagaca                                                                487


<210>  44
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NDM gB template 1 sequence

<400>  44
ccaaattaag atcatctatt tactaggcct cgcatttgcg gggtttttaa tgctgaataa       60

aaggaaaact tgatggaatt gcccaatatt atgcacccgg tcgcgaagct gagcaccgca      120

ttagccgctg cattgatgct gagcgggtgc atgcccggtg aaatccgccc gacgattggc      180

cagcaaatgg aaactggcga ccaacggttt ggcgatctgg ttttccgcca gctcgcaccg      240

aatgtctggc agcacacttc ctatctcgac atgccgggtt tcggggcagt cgcttccaac      300

ggtttgatcg tcagggatgg cggccgcgtg ctggtggtcg ataccgcctg gaccgatgac      360

cagaccgccc agatcctcaa ctggatcaag caggagatca acctgccggt cgcgctggcg      420

gtggtgactc acgcgcatca ggacaagatg ggcggtatgg acgcgctgca tgcggcgggg      480


<210>  45
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXA gBlock 1 template sequence

<400>  45
cgaagccaat ggtgactata ttattcgggc taaaactgga tactcgacta gaatcgaacc       60

taagattggc tggtgggtcg gttgggttga acttgatgat aatgtgtggt tttttgcgat      120

gaata                                                                  125


<210>  46
<211>  490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MecA gBlock1 template sequence

<400>  46
tacaacttca ccaggttcaa ctcaaaaaat attaacagca atgattgggt taaataacaa       60

aacattagac gataaaacaa gttataaaat cgatggtaaa ggttggcaaa aagataaatc      120

ttggggtggt tacaacgtta caagatatga agtggtaaat ggtaatatcg acttaaaaca      180

agcaatagaa tcatcagata acattttctt tgctagagta gcactcgaat taggcagtaa      240

gaaatttgaa aaaggcatga aaaaactagg tgttggtgaa gatataccaa gtgattatcc      300

attttataat gctcaaattt caaacaaaaa tttagataat gaaatattat tagctgattc      360

aggttacgga caaggtgaaa tactgattaa cccagtacag atcctttcaa tctatagcgc      420

attagaaaat aatggcaata ttaacgcacc tcacttatta aaagacacga aaaacaaagt      480

ttggaagaaa                                                             490


<210>  47
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hHPRT1 template sequence

<400>  47
ctctgtatgt tatatgtcac attttgtaat taacagcttg ctggtgaaaa ggaccccacg       60

aagtgttgga tataagccag actgtaagtg aattactttt tttgtcaatc atttaaccat      120

ctttaaccta aaagagtttt atgtgaaatg gcttataatt gcttagagaa tatttgtaga      180

gaggcacatt tgccagtatt agatttaaaa gtgatgtttt ctttatctaa at              232


<210>  48
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DENV ssRNA target  template sequence

<400>  48
ugacgaagac caugcucacu ggacagaagc aaaaaugcug cuggacaaca ucaacacacc       60

agaagggauu auaccagcuc ucuuugaacc agaaagggag                            100


<210>  49
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ZIK ssRNA target  template sequence

<400>  49
ccacacugga acaacaaaga agcacuggua gaguucaagg acgcacaugc caaaaggcaa       60

acugucgugg uucuagggag ucaagaagga gcaguucaca                            100


<210>  50
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HANT ssRNA target  template sequence

<400>  50
agaggcaacu ugcagauuug guggcagcuc aaaaauuggc uacaaaacca guugauccaa       60

cagggcuuga gccugaugau caucuaaagg aaaaaucauc                            100


<210>  51
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence KPC 1

<400>  51
ttgctgaagg agttgggcgg ccc                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence NDM 1

<400>  52
gcgatctggt tttccgccag ctc                                               23


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence Ctrol + hHPRT1 1

<400>  53
ggttaaagat ggttaaatga t                                                 21


<210>  54
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence S16 cntl Ecoli 1

<400>  54
cagtagttat ccccctccat cag                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence DENV1

<400>  55
cttctgtcca gtgagcatgg tct                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence DENV2

<400>  56
tggttcaaag agagctggta taa                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence ZIK1

<400>  57
ggcatgtgcg tccttgaact cta                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence ZIK2

<400>  58
ccttttggca tgtgcgtcct tga                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence OXA1

<400>  59
agcccgaata atatagtcac cat                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence OXA 1b

<400>  60
agcccgaata atatagtcgc cat                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence HANTAndes1

<400>  61
gtggcagctc aaaaattggc tac                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence HANTAndes2

<400>  62
gatgatcatc aggctcaagc cct                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Target sequence MecA1

<400>  63
tctttttgcc aacctttacc atc                                               23


<210>  64
<211>  9165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas12a.1 expression vector sequence

<400>  64
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagatttac     5040

actttatgct tccggctcgt atgtttctag agaattcaaa taattttgtt taactttaag     5100

aaggagattt aaatatgggg tcaagtcatc accaccacca ccactcaagt ggactagtac     5160

cccgtggcag catgaaagtt agcacctggg atagcttcac caaccagtac ccgctgacca     5220

agaccctgcg ttttgagctg aagccggtgg gtaaaaccct gcagaagatc caagaccgta     5280

acctgattac cgaggacgaa cagcgtcaaa aggatttcaa caaggttaag aaaatcatgg     5340

atggttacta caagcagttc atcgaggaat gcctggaagg cgcgaagatc ccgctgaaga     5400

aactggagga aaacaacaac gcgtacacca aactgaagaa agacccgtat aacaagaaac     5460

tgcgtgagga atacgcgaag ctgcagaaac aactgcgtaa actgatccac gatgagatta     5520

acaagaaaga ggaattcaag tacctgttta agaaagaatt catcaagaaa attctgccgg     5580

aatggctgga gaagaaaggt aagaaagagg aactgaaaga gatcgaaaag ttcgacaaat     5640

gggtgaccta ctttagcggc ttctttaaca accgtaagaa cgttttcagc agcgacgaga     5700

ttagcaccag catgatctat cgtattgtga acgataacct gccgaaattc ctggacgatg     5760

ttagccgttt tggtgaaatt acccgttaca aggagttcga cgcgaaccag atcgaggaaa     5820

actttgagag cgaactgaac ggtgaaaaac tgaaggattt ctttaacctg aaaaacttca     5880

acaactgcct gaaccaagaa ggcattgaga aatttaacct gatcattggt ggcaagagcg     5940

aggaaggtaa taacaaaatc aagggcctga acgaactggt gaacgagctg gcgcaaaaac     6000

aagcggacaa gaacgagcag aagaaagttc gtaaactgaa gctggcgccg ctgttcaaac     6060

aaatcctgag cgatcgtaag agcagcagct ttgcgttcga aaaatttgag gaaaacaccg     6120

aggtgttcga cgcgatcgat gaattttatg acaagattag cctggagacc ctgaagaaaa     6180

tcgaagcgac cctggagaaa ctggaggaaa aggacctgga actggtttac ctgaaaaacg     6240

atcgttgcct gaccggtatc agccaggaag tgttcggcga ccgtgagcgt gttctgcaag     6300

cgctgcgtga atacgcgaaa accgagctgg gtctgaagac cgataagaaa atcgagaagt     6360

ggatgaagaa aggtcgttat agcatccacg agattgaaag cggcctgaag aaaatcggta     6420

gcaccggcca cccgatttgc aactacttca gcaaactgga ggaaaagaaa accaacctga     6480

tccaggaaat taagaaagcg cgtaccgagt atgaaaagat cagcgacaag aaaaagaaac     6540

tgaccgcgga aagccaagag ccgaacgtgg cgcgtatcaa agcgctgctg gatagcatta     6600

tgcgtctgta tcacttcatc aagccgctga acatcaactt caagaacaag aaagagaagg     6660

acagcgaagc gctggagacc gacaacgatt tttacaacga cttcgatgaa agctttgcgg     6720

agctgggcaa catcattccg ctgtacaacc aagtgcgtaa ctatgttacc caaaaaccgt     6780

tcagcaccga gaaattcaag ctgaactttg aaaacccgaa gctgctgagc ggttgggaca     6840

aaaacaagga aaaagattac tatagcgtga ttctgcgtaa agaggaaagc tactatctgg     6900

cgatcatgac cccgaagcag aaaaacgttt tcgacgagct ggaacgtctg ccggcgggca     6960

aaaattactt cgagaagatc gattacaagc tgctgccgac cccggaaaag aacctgccgc     7020

gtatcctgtt cgcgaagaaa aacattagct tttacaagcc gagcaaagag atcgaagcga     7080

ttcgtaacca cagcgcgcac accaaacacg gtaacccgca gaacggcttc aagaaacgtg     7140

actttcgtct gagcgattgc cacaagatga tcgacttcta caagaaaagc attcagaaac     7200

acccggaatg gaaggagtat gattttcaat tcaagaaaac cgaggactac gtggatatca     7260

gcgaattcta taaagaggtt tctgaccagg gttacaagat cgaattcaag aaaattagcg     7320

agaaatacct gctggacctg gtggaggaag gtaaactgta cctgttccaa atctggaaca     7380

aggatttcag caagtacagc gaaggccgta aaaacctgca caccatctat tggaaagaac     7440

tgttcagcaa ggagaacctg agcgatatta cctataagct gaacggcgag gcggaaatct     7500

tttaccgtcc gaaaagcatg gagcgtaagg ttacccaccc gaagaaccag aaaatcgaaa     7560

acaaagaccc gatcaagggt aagaaattca gcaagttcaa gtatgacttc atcaagaaca     7620

agcgttacac cgaggatcgt ttctttttcc actgcccgat caccctgaac tttcaagcgc     7680

gtgacggcag caaaaccatc aacaagcgtg tgaacgatca cattcgtgag accaaagacg     7740

atatcttcgt tctgagcatt gatcgtggtg aacgtcacct ggcgtactat accctgctga     7800

acagcaaggg tgaaattcag gagcaaggca gctttaacgt gatcagcgac gataaggagc     7860

gtaaacgtga ctatcacgaa aaactggatg agcgtgaaaa ggagcgtgac aaggcgcgta     7920

aaagctggca gaaaatcgag accattaaga aactgaagga tggctacctg agccaaatcg     7980

tgcacaagat tgcgaaactg gcgatcgaga aaaacgcgat cattgttctg gaagacctga     8040

acctggattt caagcgtggt cgtctgaaga ttgagaaaca ggtgtaccaa aaattcgaaa     8100

agaaactgat cgacaagctg aactatctgg tttttaaaga acgtaccgaa aaagaggcgg     8160

gtggtagcct gaacgcgtat cagctgaccg gtaaattcga gggctttaag aaactgggca     8220

aggaaaccgg catcatttac tatgtgccgg cggcgtacac cagcaaaatc tgcccgaaga     8280

ccggcttcgt taacctgctg cgtccgaagt tcaagaacat cgaaaaggcg aaggagtttt     8340

tcaagaagtt caactacatc aagtacgaca gcagcgaagg tctgtttgag ttcaacttcg     8400

attacagcaa gttcatcaag aacggcaaga aagagaccaa aatcattcag gacaactgga     8460

gcgtgtatag caacggtacc aagctggttg gcttccgtaa caagaacaaa aacaacagct     8520

gggataccaa ggaagtgaaa ccgaacgaga agctgaaaat tctgttcaaa gagtacggtg     8580

ttagctttca aaaggacgaa aacatcatta gccagatcgc gagccaaaac aagaaagcgt     8640

ttttcgagaa cctgatcaag attttcaaaa ccattctgat gctgcgtaac agccgtaaag     8700

acccggagga agattacgtg ctgagctgcg ttaaggacga aaacggcgag tttttcgaca     8760

gccgtaaggc gaaagataac gagccgaaag acgcggatgc gaacggcgcg taccacattg     8820

gtctgaaggg cctgatgctg ctggaacgta tcaaggcgaa caaaggtaag aaaaagctgg     8880

acctgctgat cagccgtaac gatttcatta actttgcggt tgagcgtagc aagtaataag     8940

gatccctcga gttgacagct agctcagtcc taggtataat gctagcgttt aaggccttga     9000

caaaatttct actgtagtag atgtggcagc tcaaaaattg gctacaaaac gtttaaggcc     9060

ttgacaaaat ttctactgta gtagatctag cataacccct tggggcctct aaacgggtct     9120

tgaggggttt tttgcatatg ctgaaaggag gaactatatc cggat                     9165


<210>  65
<211>  9246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas12p expression vector sequence

<400>  65
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagatttac     5040

actttatgct tccggctcgt atgtttctag agaattcaaa taattttgtt taactttaag     5100

aaggagattt aaatatggga tcaagtcatc accaccacca ccactcaagt ggactagtac     5160

ccaggggaag catgaagaag agcattttcg atcagttcgt taaccagtac gcgctgagca     5220

agaccctgcg tttcgagctg aaaccggtgg gtgaaaccgg ccgtatgctg gaggaagcga     5280

aggttttcgc gaaggatgaa accattaaga aaaagtacga agcgaccaag ccgttcttta     5340

acaaactgca ccgtgaattc gtggaggaag cgctgaacga ggttgaactg gcgggcctgc     5400

cggagtactt cgaaatcttc aagtactgga agcgttacaa aaagaaattc gagaaggacc     5460

tgcagaagaa agagaaggaa ctgcgtaaaa gcgtggttgg tttctttaac gcgcaagcga     5520

aggagtgggc gaagaaatat gaaaccctgg gcgtgaagaa aaaggatgtt ggtctgctgt     5580

tcgaggaaaa cgtgtttgcg attctgaaag aacgttacgg taacgaggaa ggcagccaga     5640

ttgtggacga gagcaccggc aaggatgtta gcatcttcga cagctggaag ggttttaccg     5700

gctatttcat caaatttcag gaaacccgta agaacttcta caaagatgat ggtaccgcga     5760

ccgcgctggc gacccgtatc attgatcaaa acctgaaacg tttctgcgac aacctgctga     5820

tctttgagag cattcgtgat aagatcgact tcagcgaggt tgaacagacc atgggcaaca     5880

gcatcgataa ggtgttcagc gttatctttt atagcagctg cctgctgcaa gaaggtatcg     5940

acttttacaa ctgcgtgctg ggtggtgaaa ccctgccgaa cggtgaaaag cgtcagggca     6000

ttaacgaact gatcaacctg taccgtcaaa agaccagcga gaaagttccg ttcctgaagc     6060

tgctggacaa acagattctg agcgagaagg aaaaatttat ggatgagatc gaaaacgacg     6120

aggcgctgct ggataccctg aagattttcc gtaaaagcgc ggaggaaaag accaccctgc     6180

tgaaaaacat cttcggcgat tttgtgatga accagggtaa atatgacctg gcgcaaatct     6240

acattagccg tgaaagcctg aacaccatta gccgtaagtg gaccagcgaa accgatatct     6300

tcgaagacag cctgtacgag gtgctgaaaa agagcaaaat cgtgagcgcg agcgttaaaa     6360

agaaagacgg tggctacgcg ttcccggagt ttatcgcgct gatttatgtt aaaagcgcgc     6420

tggaacagat tccgaccgag aagttctgga aagaacgtta ctataagaac atcggcgatg     6480

tgctgaacaa gggtttcctg aacggtaaag aaggcgtttg gctgcaattt ctgctgatct     6540

ttgacttcga atttaacagc ctgttcgagc gtgaaatcat tgatgagaac ggcgacaaga     6600

aagtggcggg ttataacctg ttcgcgaagg gttttgacga tctgctgaac aacttcaaat     6660

acgaccagaa ggcgaaagtg gttattaagg attttgcgga cgaagttctg cacatttatc     6720

aaatgggcaa atacttcgcg atcgagaaga aacgtagctg gctggcggac tatgatattg     6780

acagcttcta caccgatccg gagaagggtt acctgaaatt ttatgaaaac gcgtacgagg     6840

aaatcattca ggtttataac aagctgcgta actacctgac caagaaaccg tatagcgagg     6900

acaagtggaa actgaacttc gaaaacccga ccctggcgga tggttgggac aagaacaaag     6960

aggcggataa cagcaccgtg attctgaaga aagacggtcg ttactatctg ggcctgatgg     7020

cgcgtggtcg taacaagctg ttcgacgatc gtaacctgcc gaaaatcctg gagggtgttg     7080

aaaacggcaa gtacgaaaag gtggtttaca agtacttccc ggatcaggcg aagatgttcc     7140

cgaaagtgtg ctttagcacc aaaggcctgg aattctttca accgagcgag gaagttatca     7200

ccatttacaa gaacagcgag ttcaagaaag gttatacctt taacgtgcgt agcatgcagc     7260

gtctgattga tttctataaa gactgcctgg ttcgttacga aggttggcaa tgctatgatt     7320

ttcgtaacct gcgtaagacc gaggactacc gtaaaaacat cgaggaattc tttagcgatg     7380

tggcgatgga cggctacaag attagcttcc aggacgttag cgagagctat atcaaggaga     7440

agaaccaaaa cggtgatctg tacctgtttg agatcaagaa caaagactgg aacgaaggtg     7500

cgaacggcaa gaaaaacctg cacaccattt atttcgagag cctgtttagc gcggataaca     7560

tcgcgatgaa cttcccggtg aaactgaacg gccaggcgga gatcttttac cgtccgcgta     7620

ccgaaggtct ggagaaggaa cgtatcatta ccaagaaagg caacgttctg gaaaagggtg     7680

acaaagcgtt ccacaagcgt cgttacaccg agaacaaagt gttctttcac gttccgatta     7740

ccctgaaccg taccaagaaa aacccgttcc aatttaacgc gaagatcaac gacttcctgg     7800

cgaaaaacag cgatatcaac gtgattggtg ttgaccgtgg cgagaaacag ctggcgtatt     7860

ttagcgtgat tagccaacgt ggcaagatcc tggaccgtgg tagcctgaac gtgatcaacg     7920

gcgttaacta cgcggagaag ctggaggaaa aagcgcgtgg tcgtgaacag gcgcgtaagg     7980

attggcagca aatcgagggc attaaagacc tgaagaaagg ttatattagc caggtggttc     8040

gtaaactggc ggatctggcg atccaataca acgcgatcat tgtgttcgag gacctgaaca     8100

tgcgttttaa gcaaattcgt ggtggcatcg agaaaagcgt ttatcagcaa ctggaaaagg     8160

cgctgatcga taaactgacc ttcctggtgg agaaggaaga aaaggacgtt gaaaaggcgg     8220

gtcacctgct gaaagcgtac cagctggcgg cgccgttcga aacctttcag aagatgggta     8280

aacaaaccgg cattgtgttt tatacccaag cggcgtacac cagccgtatc gatccggtta     8340

ccggctggcg tccgcacctg tacctgaaat atagcagcgc ggaaaaggcg aaagcggacc     8400

tgctgaagtt caagaaaatt aagttcgtgg atggtcgttt cgagtttacc tacgacatca     8460

agagcttccg tgagcagaag gaacacccga aagcgaccgt gtggaccgtt tgcagctgcg     8520

ttgagcgttt tcgttggaac cgttatctga acagcaacaa aggtggctac gatcactata     8580

gcgacgtgac caagttcctg gttgagctgt ttcaggaata cggcatcgac ttcgaacgtg     8640

gtgatattgt gggccaaatc gaggttctgg aaaccaaggg taacgagaag ttctttaaga     8700

acttcgtgtt ctttttcaac ctgatctgcc agattcgtaa caccaacgcg agcgaactgg     8760

cgaagaaaga cggcaaggac gatttcattc tgagcccggt tgagccgttt ttcgatagcc     8820

gtaacagcga gaagttcggc gaagacctgc cgaaaaacgg tgacgataac ggcgcgttta     8880

acatcgcgcg taaaggtctg gttattatgg ataagatcac caaattcgcg gacgagaacg     8940

gtggctgcga aaagatgaaa tggggtgacc tgtatgtgag caatgtggag tgggataact     9000

ttgtggcgaa taaataataa ggatccctcg agttgacagc tagctcagtc ctaggtataa     9060

tgctagcatc tacaaaagta gaaatctaat agggatattc gaggtggcag ctcaaaaatt     9120

ggctacaaaa catctacaaa agtagaaatc taatagggat attcgagcta gcataacccc     9180

ttggggcctc taaacgggtc ttgaggggtt ttttgcatat gctgaaagga ggaactatat     9240

ccggat                                                                9246


<210>  66
<211>  8658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas12q expression vector sequence

<400>  66
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagatttac     5040

actttatgct tccggctcgt atgtttctag agaattcaaa taattttgtt taactttaag     5100

aaggagattt aaatatgggg tcctcccatc atcaccacca ccactcttca ggcttggtac     5160

cgcgtggttc catgatcaac atagacgaat tgaaaaattt atataaggtg caaaagacca     5220

tcactttcga acttaagaac aagtgggaga acaaaaatga tgagaacgac agagtagagt     5280

tcttgaagac tcaggagtgg gtcgaaagcc ttttcaaggt cgatgaagag aactttgatg     5340

agaaagagtc tatccctaac ttgttagact tcggacagaa gattgcgtcc ttgttttaca     5400

agctgagcga ggacatagcg aacaaccaaa ttgatacgcg ggtattgaaa gtctcgaaat     5460

tccttttaga ggaaattgat agaaatcaat accacgagaa aaaaaacaag cccacaaagg     5520

taaaagaaat gaatcccaac acaaacaaaa gttatataaa agaatataag ctgtccgacc     5580

aaaacacact gtacgtgtta ttaaagataa tggaagatga aggtcgggga ttacaaaaat     5640

ttttgtacga taaagcggac cggttaaacc tgtacaatca aaaagttcgg agagacttcg     5700

ccttaaagga atcaaatgag caacaaaaat tctctggaaa tgccaactac tatgggaata     5760

taaagctgct tatagatagc ttagaagatg cagtccggat cattgggtat ttcactttcg     5820

acgatcaagc agaaaacgca caaatcaatg aatttaagtc cgttaaacag gaaatgaata     5880

ataatgaagc gtcttaccaa gcactgaaag acttcgctat tgataacgca aaaaaagaga     5940

tagaattgac gacgttgaac caccgggcgg tcaacaagga tccaaaaaag attcaagaac     6000

agattgagga agtcgaaaat ttcgaagaag atattaacca gttaaagcat cagatatcag     6060

ccttgaatga taagaagttt gacgtggtta gcagattaaa gcacgctctt ataaaaatgt     6120

taccagaact gaatcttttg gatgctgagt cggaacaggg ccgtgaagtc cagcagatat     6180

atcaagacaa aaaaaacggg ttggagcttg atgactttaa atttaacctt ttaaaacatc     6240

atcaatggca aaaaacgatc ttcaagtata ttaagcttga gggcttagtt ctgccagacc     6300

tttacgcgga aaacaaacaa gataaaatca aggtttatat tgagaattat agacagagtg     6360

gtgagcgtat ttctaagaag gcgagagagg aattaggaaa aatcgataaa cgcgaagagt     6420

tcaatggaaa tgacgaactt aagaaggcat ggtatgagta taaggacttc tgtagagaca     6480

aacgtaataa gagcgtggaa cttggcaata agaagtcgct gtacaatgcc ataaagcgcg     6540

aagttttgcg gcaaaaaatg tgcaaccatt tcgctgtgct ggtgtccgac ggtgaagata     6600

cttcccctta ttattatctg atattaatcc cgaacgagaa ctccgatgaa atgaatagaa     6660

cgttcaagga attgaaggcc tccgagggga attggaagat gttggattac aatcgtctga     6720

ccttcaaagc cttggagaaa ttggccctgt tacggtcgtc taccttcgag atagcggatc     6780

aggaactgca agaagaggca aaaaagatct gggaggagta caaggaaaag gcgtacaaag     6840

acttcaaaaa caaaaagtta ttacagggtt tatcgggaag acagcgggag gagaaaaagc     6900

aagaattgca aaaggagagc ctgaatagag taatcaatta cttgatcaga tgcattcagt     6960

cattgcccga cagcggaaaa tacaacttta actttaaaga gcctcatcaa taccaatcgc     7020

ttgaagagtt tgccgaggag attgatcggc aaggttatca ctgtgcttgg aaaaacgttt     7080

ctaaagataa actgatggaa ttggaagcga tggaaaagat taaggttttc aaacttcata     7140

acaaagactt tcgcaaggta aaactgaacg actccaagca caaccctaat ctttttactt     7200

tgtactggtt agacgccatg aatttggata aggttaacgt ccgcctgtta ccggaagttg     7260

acctttacaa gagagctaag gaaacacagc tgaaattgtt cgaacgtgat gtgaaatgca     7320

atatcaataa ccaaaagatt aaatctatca aggagaagaa tagactgttt caggacaagt     7380

tgtatgctag ttttaagtta gagttttatc cagaaaacga aggattaggt ttcgagcagg     7440

taaatgacaa ggtcaataac ttctgcggta gcgatacggc ctattatctt gggcttgatc     7500

gtggagagaa agagcttgtt acattctgcc tggtggactc tgatggccgc ctggtaaaaa     7560

acggagactg gaccaagttt aaagaggtga actatgccga caaactgaag caattctact     7620

actcaaaagg cgaaatagag agtacccaac aacagctgtt agaagcccgg gacaatatta     7680

aacaagcgac caacacggaa gataaggagt ccatgaaact gaattataag aaactggaac     7740

tgaagttaaa acaacagaat ttgctggcgc aagaattcat aaaaaaagcg tactgcggct     7800

accttatcga tagcattaat gagattctga gagaatatcc aaatacttat cttgtcttag     7860

aggatttgga tatcgcgggt aaagcggatc cagagtcggg gatgactaat aaagagcaga     7920

acttaaacaa aacgatgggg gcttcagtat accaggccat tgagaatgcg atcgtaaata     7980

aattcaaata tcgcaccgtg aaattgtccg atatcaaggg ccttcagact gtacctaatg     8040

tagtgaaggt cgaagactta cgggaagtga aagaggttga agatggggaa cacaagttcg     8100

ggttaataag atcagttaag agcaaggatc aaatcggtaa catacttttt gtcgacgagg     8160

gggagaccag taacacttgt ccgaattgcg gttttaatag tgattggttt aaacgcgatg     8220

ttgattttga cttagaaata gtcgctactg taaacgggca aaagaatgcc gtgattgagc     8280

aaaatgacaa aaaatactgt ttcccgggcg aaatatataa attggaaatc attaataaag     8340

agtacgaaac aaacaagcgt aatcttgcca tgatttttaa acctcgggcc aaagcgtgcc     8400

gtaaatttat caataataat ttagataaga acgattattt ctattgtccc tactgcgcct     8460

tctcgtcgaa gaattgtaac aacccgaaac tgcagaacgg cgatttcgtg gtatattcag     8520

gagacgatgt tgctgcttac aatgttgcta tcagaggaat taacctgctg aacaatatta     8580

aatagctagc ataacccctt ggggcctcta aacgggtctt gaggggtttt ttgctgaaag     8640

gaggaactat atccggat                                                   8658


<210>  67
<211>  8367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9.1 expression vector sequence

<400>  67
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagatttac     5040

actttatgct tccggctcgt atgtttctag agaattcaaa taattttgtt taactttaag     5100

aaggagattt aaatatgggc agcagccatc atcatcatca tcacagcagc ggcctggtgc     5160

cgcgcggcag catgcagagg attttcggcc tcgatatcgg caccacgtcc atcggctttg     5220

cggtcatcga ccacgaccgc gaccaaggcg tcggccgcat ccaccggctg ggcgcgcgca     5280

tcttcccgga agcgcgcgac gagaagggaa caccgctcaa ccagcatcgg cggcaaaagc     5340

gtctcgcgcg ccgccaattg cgccggcgcc ggcttcggcg caaggcgctc aacgaactgc     5400

tttcggcccg cgggatgctg ccgcgcttcg gcacgtccgc ttggcacgac gcgatggcgc     5460

tcgaccctta cgcgctccgt gcacggggta cggaggaggc gttgcagccg gtagaggtcg     5520

gtcgggctct ctatcacctc gcccagcgtc gccacttcaa gccacgggac gaggctgcgg     5580

aagccgacga gcaggaggtg ggcgatcagg aggccgagac caagcgtgag aagctgctgc     5640

aggcgttgcg ccgcagcggt cgaacgctgg gccaggaact ggcggcgcgc ggtccgcacg     5700

agcgcaagcg gcacgagcac gctttgcgct cgaccgtcga gaccgagttc gagcggctcc     5760

tcaccgcgca agcgcggcat cacgagatcc ttcgcgatcc cgagttcgtc gaggaactga     5820

gagagaccat cttcgcgcaa cggcccgtct tttggcggac gagcacgctc ggcacgtgcc     5880

cgttcgttcc aggcgcaccg ttgtgcccga agggtgcttg gctctcccgc cagcggcgca     5940

tgctggagca ggtcaacaac ctcgccatca ccggcggcaa cgcgcgtccg ctcgaccacg     6000

aggagcgacg agcgatcctc gccgtcttac agacgcaggc cagcatgagc tggggcgcgg     6060

tccgaaccgc gcttaagccg ctcttcaagg cacgcggcga ggcgggcgcc gagcgtcggc     6120

tccggttcaa tctcgaagag ggcggcggta agacgctgct cgggaacccg ctggaagcga     6180

agctcgcccg gatcttcggc gaagcctggg ccacgcaccc tcaccgcgac gcgatccgtg     6240

agacgatcca tgaccgcctt ttcgccgcga cctataacgc gaagggcgcg cagcgcatcg     6300

tcatccttcc ggcatcccaa cgcgctgaac ggatgcgggg ggtcatcgcc ggcctccaag     6360

cggatttcgg cctttcccac gagcaggcga tggcgcttgc ggagctgccg ctgacgcccg     6420

gctgggaacc ctattcgagc gaagcccttc gcgcgttaat gccgaagctg gaggaaggcg     6480

tgcgcttcgg cgccctcgtc gtggcccctg aatgggaaga ttggcgcgag gccaccttcc     6540

cccagcgcga gcggccgacc ggcgaggtgc tcgacctctt gccttcaccg aaatgccacg     6600

atgagagccg ccggcagacg cggctgcgga acccgacggt gctgcgcacg cagaacgagc     6660

tgcgcaaggt cgtcaacaac ctgatccggg cgcacggcaa gcccgacatc atccgcgtcg     6720

aggtcgcccg cgaggtgggg ctttccaagc gcgagcgtga agatcgctac aacgggatgc     6780

ggcgccagga gcgccagcgg caagcggcga tcaaagacct ccaagccaag ggcttcgccg     6840

agccgtcgcg cgccgacgtc gagaagtggc ttttgtggaa ggagagcaag gagacctgcc     6900

cttacacggg ggacaagatc tgcttcgacg ctctgtttcg ccgcggtgag tttcaagtgg     6960

agcacatctg gccgcgctcg cgctcgttcg acgacagctt ccgcaacaag accctgtgtc     7020

ggcgcgacgt gaacctcgcc aagggtaacc aaacgccctt cgagttcttc gagagccgac     7080

ccgaggagtg ggaggccgtg aagcgccgcc tcgatggctt gcaggccaag cgggcaggcg     7140

gtgaggggat ggcgcgcggc aaggtgaagc gcttcgtcgc gagcacgttg ccggacgatt     7200

tcgcgcagcg tcagctcaac gacacgggct gggcggcgcg cgaggcggtg gccttcctca     7260

agcggctgtg gccggacgag gggcaagccg cgccggtccg cgtccaggcg gtcacggggc     7320

gggtgacggc gcagcttcgc cacctggggg gcctcgatgg cgtgctgtcg gacggtgctc     7380

gaaagacgcg tgacgaccac cgccatcacg ccgtcgatgc gctggtcgtc gcctgcacgc     7440

atccgggcat gaccgagcgg ctcagccgct actggcagca gaaggaggac gagcgcgccg     7500

aacgaccgca gctggaccca ccgtggccca cgatccgagc ggacgccgag gcggccaagg     7560

acttaatcgt cgtctcgcac cgggtgcgca agaagatctc gggaccgttc cacaaggaaa     7620

ccgtctatgg cgcgaccgac gagcgcgagg tcacgcgcgg gcttgagtac gagaaattcg     7680

tcacgcggaa gcgcgtcgag gacctgacga aatccatgct cgccgacatc cgcgacgaca     7740

gggtgcggca aattgtgacg gcgtgggtgg ccgagcgcgg cggcgacccg aagaaggcgt     7800

ttccgcccta tccgacgctg gggtcgagcg gacccgagat ccgcaaggtg cgcgttctga     7860

tccgccggca gcccaccttg atggcacggg cagcgacggg cttcgctgat ctcggagcga     7920

accaccatgt cgccatctac aagaccgccg acgagcgatt cgccttcgag gtcgtcagct     7980

tgctggaggt cgccaggcgc gtcgaccgcg gtgaaccgcc cgtgaagaga cagcgaggcg     8040

acgagaagct cgtgatgtct ttggcgcagg gcgatctgat acggttcgcc aaaacgcccg     8100

atgcggaagc agcaatttgg cgtgttcaga aaatcgcaac taaaggtcag atatcgctcc     8160

ttcaccacga tgacgcttcg ccgaaggagc cgagtctctt tgaaccgatg gttggtgggt     8220

tgatggctcg gaacccggag aagctggcag tcgatcccat cggccgagtg cgcaaggcag     8280

gcgactgact agcataaccc cttggggcct ctaaacgggt cttgaggggt tttttgcata     8340

tgctgaaagg aggaactata tccggat                                         8367


<210>  68
<211>  9378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas 9.2 expression vector sequence

<400>  68
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagatttac     5040

actttatgct tccggctcgt atgtttctag agaattcaaa taattttgtt taactttaag     5100

aaggagattt aaatatgggc agcagccatc atcatcatca tcacagcagc ggcctggtgc     5160

cgcgcggcag catgaagaaa gaaaaagtgt acatggggct agatcttggc acgaactctg     5220

tcggctgggc ggtaacggat aacgactata aggtgctcaa gtttaaacgg cgcgctatgt     5280

ggggggttcg gctctttaat gaagccaatc cggctgtcga gaggcgtgtt gcccgttcaa     5340

atcgccgtcg cctggcccga aaaaaacaac gcgtggcttg gctgaaagaa atatttaaga     5400

attccattag cgaaattgat ccggaatttt tcgaccgtct tgaacaaagc gcgctttggg     5460

cagaagacaa aaatgtcgcc ggaaaatact ccctttttaa tgagaaaaaa ttaaccgata     5520

agacattcta tcggaaattt cccaccgttt ttcacctaaa aaaagcgctt atggacggca     5580

aaataaaaaa acctgatatt cgctttgtat atcttgcctt gtcccactat ctgcaaaaca     5640

gaggccattt tctcttggaa aatgagctga acagtgttga agatatagac attcgggata     5700

tttttaacag tcttaatgaa agaattcatg ttcttattga cagcggtgat gatatggttc     5760

ctgcttttga tttgacaaac cttgatgatt tgaaacaaat tgccacagac acaaatatat     5820

ccgggaaaac gcaggaaaaa gaagccttta taaaaaccct gttaaatggg gccaaacagc     5880

ctgccttaga ggcaattatt aaattatgta caggcggctc ggctaattta tcaaaaatct     5940

ttggtgatat gtttgaattt gaaagtgaaa tcaaatcaat atcattcgaa aaggccaact     6000

tcgaagatga aatcgctccc aagctgcaag attgtctggg agattactat cagattattg     6060

agctggctca gcagatttac agctggtaca cgctttataa ggtatgcagc ggtcgaccgt     6120

cggtctctca cgccaaagtg gaggattacg aaaaacacaa agaacagctg tcccacctaa     6180

aagtgctggt aagaaaacac ttttcgaaaa atgtctaccg ggaaatattc cgaaaagaag     6240

acgacaaaat ccataactat gtatcctaca tatccggcaa aaaggaccgc gacgaatttt     6300

ataaatatct caaaaaaacg ttagaaaaaa aatctacatt caagaaaacg tctgaatttg     6360

agaatatttc tcgcgccatt gaacagcaaa actacctgcc gaaacaacgg gtcaaagaca     6420

actctgtggt gcctcagcag ctatacaaac aagaaatcgt aaaaatcctc aacaaccttt     6480

catcacacta ccccttttta tcacaaaaaa cagacgggat cagcaatcga gaaaagatta     6540

tcaaaatctt tgaataccgc atcccatact atgtcggtcc tctttgcgat atccatcgtg     6600

cgggggatga cgggttctcc tggctggttc gtgactgcag taaaaagatt actccttgga     6660

acttcgagca agtcgtcgat atcccccagt ctgctgaaaa tttcattaag aacatgaccc     6720

gtaaatgcac ctatttaaaa cagtataatg tgctgccgaa aaattctctc ctctatagcg     6780

agtatagcgt actaaatgaa cttaacaatg tgcgcatcaa aactaaaaag ctgaccccta     6840

agctaaaaga aaaaatgctc aacacattat ttcgccaaaa gaagaatatt tcgataacga     6900

gcttgattca ttggcttgtc agtgaaggag tgtatgagaa aggggagatt gaaaaatcag     6960

acgtcagcgg tgttgattcc aattttacca gctctctttc tgcagccatt tcttttgatc     7020

gtatcattgg tgaaaagatg aaaaacaaaa aaacccaaaa aatggtcgag gagatcataa     7080

actggctcgc ccttttttcg gacaaaaaaa tactacaaca aaagattgta gagaaatatc     7140

aagataaagt ctcgcaagaa caaatcggaa aaattctgcg cctcaaccta agcggatggg     7200

gacgactttc ttcggagttt ctgcaactga aaaactccca accgggagaa cacgacggaa     7260

aaacgctcat caatatcatg cggcagaccc agatgaatct gatggagatt attcactctc     7320

cccagttcag tttcaatacc gttattgaaa cggaggccaa aaaacagcta acgggacaca     7380

ttacccacag tcatgttgag gcgctgtact gctctcctgt ggtcaagaaa cagatatggc     7440

aggccctgca aatcgccctg gagctaaaga aaaccttaaa gaaagacccg aacaaaattt     7500

ttgtggagac aacccggcat gaaggggaga aaaaacggac cacaagccgt cacaaacaac     7560

tactcgagtt ataccaagcc gccaagtccc atctgcccga cctgacgaaa agtataaagg     7620

aactaaacga tgcgctaaaa gatacagagc cggagaagat gaaacggaaa aaactgtttc     7680

actactacaa acaactggga cgttgtatgt atacaggcag gcccatcagt ctagaggatc     7740

tgtttaccaa taaatatgac attgatcata tttatcccca gagtttaacc aaagatgaca     7800

gttttactaa tactgtactg gtggaacggc tatcaaacgc ggagaaatca gacgcattcc     7860

ctcttgacag taaaacaaga aaagaccgtc aaggactgtg gcgctgttta cgacggaacg     7920

gactaattac caaagaaaag tactaccgct taacacggga aacacctcta agcgaagaag     7980

aaaaagcggc ctttattcgt cgtcagctgg tggaaaccag ccagacaacc aaggaagtaa     8040

tccgatttct ggcgaccctt ttcccaaagt caaaagttgt gtatgtaaag agcggcaacg     8100

tcagcgactt tcgccgtgac ttttccccgt ccctgcccga aaacaaaact aacggcaaag     8160

accccaaggg gataaccgac tacagcatga ttaaagtgag ggaaatcaat gatttgcacc     8220

acgcgaaaga cgcgtattta aacatcgtgg tcggcaatgt ctacgacacc aaatttcgct     8280

accgaggcaa agacctcacg gccatagtgc gcgaaaaagc gaggcagtac catttatccc     8340

gtttgtttct ttactctacc gacggcgcct ggatcggagc ggctgatgaa aacagaggga     8400

agcaacgacc gagtattgaa accgtgatcg cggaaatgcg gcgaaatagc tgtcaggtaa     8460

cgtgggaagc cgtctttaaa aaagggcagc tgtgggacat gaacgccaaa agtaagcggc     8520

cgggactgtt gccgatcaag aaagaactat ccgatacggc aaaatatgga gggtaccagg     8580

ggaagaccgc gtcttatttt gtggtcgttg agtatgagaa taaaaaaggc gaacgtgaaa     8640

aaaaactgga atcggtcccg atttatgtga aagcgctcag taaacaaaag ccggacgctg     8700

tcaattcttt cctacgggat acactgggtc tggagaaacc aagcgtcatg gtcgacaaca     8760

tcaaaatcgg ctccatcgtc gagatcaacg gggcccgaat ggtccttacg gggaataatg     8820

aagttctagt atttgggcgt atcgcgtccc aactgatcct ggatataacg atggccgcct     8880

atctaaaacg aatgtttaag ctgcttgctg acacagccaa gatcaaagag aacaatgtct     8940

actttaaaaa ctgcggctat ctggataagg agacgaacct ggcagtatac gatacgttta     9000

ttgccaagct gaaactgccc cggtatgctc agattatcac ccatagccta tatgagaaga     9060

tggaaagcaa tcgtgatgtg tttatcaacc tttcactggc cgaccagtgt aatctgctgg     9120

ccggcgtact gcctgcgcta cagtgtaaca gccaaaatgc cgatctgtct cttcttggtg     9180

aaggtaaagc ggtcggaaat atcgcatttt caaaaaacgc gatcctgaaa aagaatcagg     9240

tccgtcttgt tgattgctcc attaccgggc tcttcgaaaa cagcagaaat atggcataac     9300

tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgcat atgctgaaag     9360

gaggaactat atccggat                                                   9378


<210>  69
<211>  1871
<212>  DNA
<213>  Andes orthohantavirus

<400>  69
tagtagtaga ctccttgaga agctactgct gcgaaagctg gaatgagcac cctccaagaa       60

ttgcaggaaa acatcacagc acacgaacaa cagctcgtga ctgctcggca aaagcttaag      120

gatgccgaga aggcagtgga ggtggacccg gatgacgtta acaagagcac actacaaagt      180

agacgggcag ctgtgtctac attggagacc aaactcggag aacttaagag gcaacttgca      240

gatttggtgg cagctcaaaa attggctaca aaaccagttg atccaacagg gcttgagcct      300

gatgatcatc taaaggaaaa atcatctctg agatatggga atgtcctgga tgttaattca      360

attgatttgg aagaaccgag tggacagact gctgattgga aggctatagg agcatacatc      420

ttagggtttg caattccgat catcctaaag gccttataca tgctgtcaac ccgtgggaga      480

caaactgtga aagacaacaa agggaccagg ataaggttta aggatgattc ttcctttgaa      540

gaagtcaatg ggatacgtaa accaaaacac ctttacgtct caatgccaac tgcacagtcc      600

actatgaagg ctgaagaaat cacgccagga cgatttagga caattgcttg tggccttttt      660

ccagcacagg tcaaagcccg aaatataata agtcctgtaa tgggagtaat tggatttggc      720

ttctttgtaa aggattggat ggatcggata gaagagtttc tggctgcaga gtgtccattc      780

ttacctaagc caaaggtcgc ctcagaagcc ttcatgtcta ccaataagat gtattttctg      840

aacagacaga gacaagtcaa tgaatctaag gttcaagata ttatcgattt gatagaccat      900

gctgagaccg agtctgctac cttgtttaca gagattgcaa caccccattc agtctgggtg      960

tttgcatgtg cacctgaccg gtgccctcca actgcattgt atgttgcagg ggtaccggaa     1020

cttggtgcat ttttttctat ccttcaggac atgcgtaata ccatcatggc atctaaatct     1080

gtagggactg cagaagagaa gctaaagaaa aaatctgcct tctaccaatc atacctaaga     1140

aggacacaat ctatgggaat ccaactggac cagaagatca taatccttta catgctatca     1200

tggggtaaag aagctgtgaa tcacttccat cttggtgatg atatggaccc tgaactcagg     1260

cagctagcac aatctctgat cgatactaag gtgaaggaga tctccaacca agagccactt     1320

aagttgtagg tgcttaatga aatcatgatt gaagaaagac tttccgggct tgtgccacat     1380

attaatcatc tcaggaccta tccttaatgt gattaatagg gttttattat aagggcagtt     1440

aatggggttg gttactaact atgggtaagg gttcattacc atttttgcac tagggttaaa     1500

gggccactac attgtatttg cactaaggga aatgggaggt gggttagttt gtatttagtt     1560

gttaagtttt ttataatcat atgttaatga ggaattagct atatgatatc actgattgat     1620

tggctatttt taggttaagt aattgtagtt aaatagttgt gttaagttag tatgttaagg     1680

tttataggtt aagatttact aacaatcata ttatgtcatt agatgtaaat ttcattcctg     1740

gcttgcttct gctttcgcat tgctaaccta caacaagact acctcaccca ctacccctcc     1800

cctattctac ctcaacacat actacctcac atttgatttt tcttgattgc ttttcaagga     1860

gcatactact a                                                          1871


<210>  70
<211>  23
<212>  DNA
<213>  Andes orthohantavirus

<400>  70
gtggcagctc aaaaattggc tac                                               23


<210>  71
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  71
cccgattgac gctatagtaa gcatcgag                                          28


<210>  72
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  72
gcgtcccata aaggtatgac ttgtatt                                           27


<210>  73
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  73
acgcacgcag tattgaatac gcgaatag                                          28


<210>  74
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  74
gttcacgtaa aacttaatcg ttgaact                                           27


<210>  75
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  75
tggtagtgcc aacacgtgcg cccacca                                           27


<210>  76
<211>  29
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  76
tcggtggtgg gcgaacattg actgttggt                                         29


<210>  77
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  77
ccgattcctt ctcgttcgcc cgtgacca                                          28


<210>  78
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  78
gttgcgggag atactacttc aatataca                                          28


<210>  79
<211>  29
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  79
ggtagccgaa atgaattcgg tataacccg                                         29


<210>  80
<211>  28
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  80
aaccagtatc ctaccgtgaa gttgtcgc                                          28


<210>  81
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12a.1 spacer

<400>  81
gggggtttga gtgggcaacg caaggaa                                           27


<210>  82
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  82
ttcagatgtt tgctctttga catatcg                                           27


<210>  83
<211>  30
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  83
atggtgattt aaaaacaaaa ctcggcgcga                                        30


<210>  84
<211>  29
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  84
ccttgtgcaa aatagacagg ttagaccgt                                         29


<210>  85
<211>  30
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  85
cgaaaatcca gctaaactca ttctctgatt                                        30


<210>  86
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  86
ttgattggag gaacaagcta cataaa                                            26


<210>  87
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  87
cgtatgggtg taatttaatc ggtttg                                            26


<210>  88
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  88
atgaatcgta taagatatga tctgaat                                           27


<210>  89
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  89
aatcgtagcg ataaccgaag aacaaat                                           27


<210>  90
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  90
aacccatatg ttttattatc ctgctga                                           27


<210>  91
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  91
tacaaaatta aggcggtcta ggaga                                             25


<210>  92
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  92
tccatttgat gataaccata agaat                                             25


<210>  93
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  93
aaaataatgt aatataatac aatat                                             25


<210>  94
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  94
ctcgacactg ggacaacttc cgtat                                             25


<210>  95
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  95
caataaatac tgattagaag aagatat                                           27


<210>  96
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  96
ctgtcaaagc catagtcttg atccagc                                           27


<210>  97
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  97
gcgcaaagca tcagcgcaat ggctcg                                            26


<210>  98
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  98
tggcagagtt cgggccaagt atcat                                             25


<210>  99
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  99
gtagcgttct gttacgtgcc agcga                                             25


<210>  100
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  100
cggaataatg tatgtcttac cgaggc                                            26


<210>  101
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  101
ctacgattac cttaacgacc ctaac                                             25


<210>  102
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  102
atgattgaca caataattaa ctggtt                                            26


<210>  103
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  103
ataccgtctg tacctattgg gggca                                             25


<210>  104
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  104
aaaagtgcta aaattcttaa cggaa                                             25


<210>  105
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  105
cttgctgaat tcggctcaag catcat                                            26


<210>  106
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  106
cagcatggga tagaacgctt ccgagc                                            26


<210>  107
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  107
ccactagcat ctcctaggat agttgga                                           27


<210>  108
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  108
atataagaca gctccaagct cccgtt                                            26


<210>  109
<211>  27
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  109
tacctctgga gtttaatctt tgataga                                           27


<210>  110
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  110
aatgaaaaac caaaatccgc acctta                                            26


<210>  111
<211>  26
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  111
gacgcatatt gcatagcggt ttatgc                                            26


<210>  112
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  Cas12p spacer

<400>  112
ataaattcac aaactaactt gtaac                                             25


<210>  113
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12p deleted sequence

<400>  113

Lys Asn Gly Asn Pro Gln Lys Gly Tyr 
1               5                   


<210>  114
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12p deleted sequence

<400>  114

Pro Ala Lys Glu 
1               


<210>  115
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12p deleted sequence

<400>  115

Lys Asn Gly Asn Pro Gln Tyr 
1               5           


<210>  116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA scaffold for Cas12a1

<400>  116
aaauuucuac uguaguagau                                                   20


<210>  117
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA scaffold for Cas12p

<400>  117
agauuucuac uuuuguagau                                                   20


<210>  118
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  118
gtggcagctc aaaaattggc tacaaaacca gtt                                    33


<210>  119
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  119
gatcgcgccc cactgcgttc tcc                                               23


<210>  120
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  120
auggcaccug uguaggucaa cca                                               23


<210>  121
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ssDNA fluorescently labeled reporter


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  FAM reporter fluroscent dye moiety attached

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Iowa Black FQ quencher moiety attached

<400>  121
ttattatt                                                                 8


<210>  122
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  122

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His Lys Arg  Pro Ala Ala 
    1220                 1225                 1230             


Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys Lys Gly  Ser Tyr Pro 
    1235                 1240                 1245             


Tyr Asp  Val Pro Asp Tyr Ala  Tyr Pro Tyr Asp Val  Pro Asp Tyr 
    1250                 1255                 1260             


Ala Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1265                 1270             


<210>  123
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  123
ugugcugacu cuaucauuau ugg                                               23


<210>  124
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence


<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  FAM reporter fluroscent dye moiety attached

<400>  124
tcatttagaa agtagatatt gattgatttt agcgaaagcc aatttttgag ctgccactga       60

tgtaaaagtt                                                              70


<210>  125
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  125
gctatcttaa tccttaatct atcctcaaac gttctattaa tggccgtgtc aatcaatatc       60

tactttctaa atgaaacttt tacatcagtg gcagctcaaa aattggcttt cgctaaaatc      120


<210>  126
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  126
taagcgccct tgcgctttcc ccagccttcg ggttggttgc cttttagtgc aagggcgcga       60

ttatt                                                                   65


<210>  127
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target sequence

<400>  127
gattttagcg aaagccaatt tttgagctgc cactgatgta aaagtttcat ttagaaagta       60

gatattgatt gacacggcca ttaatagaac gtttgaggat agattaagga ttaagatagc      120


<210>  128
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reporter sequence


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  joined by phosphorothioate bonds

<400>  128
cccccccccc cccccccctt att                                               23


<210>  129
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reporter sequence


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  joined by phosphorothioate bonds

<400>  129
cccccccccc ccccccccuu auu                                               23


<210>  130
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric guide sequence

<400>  130
agacacgaga gggcagccaa aaatggc                                           27


<210>  131
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric guide sequence

<400>  131
agacacgaga gggcagccaa aaatggc                                           27


<210>  132
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chimeric guide sequence

<400>  132
agauuucuac uuuuguagau guggcagcuc aaaaauuggc                             40


<210>  133
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric guide sequence

<400>  133
agacacgaga gggcagccaa aaattggc                                          28


<210>  134
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for Cas 9.1 crRNA

<400>  134
acuguagcaa gacgaagggc cggcgcaauc cgcagc                                 36


<210>  135
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for Cas 9.3 crRNA

<400>  135
uuacauuagu uuaaaaccaa acucccuuug gcgucg                                 36


<210>  136
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for Cas 9.4 crRNA

<400>  136
ugacgcaaag uaaaauuuag gguuaguuua guguug                                 36


<210>  137
<211>  18
<212>  PRT
<213>  Campylobacter jejuni

<400>  137

Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp Ala 
1               5                   10                  15      


Phe Ser 
        


<210>  138
<211>  22
<212>  PRT
<213>  Campylobacter jejuni

<400>  138

Leu Pro Arg Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg 
1               5                   10                  15      


Lys Ala Arg Leu Asn His 
            20          


<210>  139
<211>  13
<212>  PRT
<213>  Campylobacter jejuni

<400>  139

Val His Lys Ile Asn Ile Glu Leu Ala Arg Glu Val Gly 
1               5                   10              


<210>  140
<211>  16
<212>  PRT
<213>  Campylobacter jejuni

<400>  140

Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
1               5                   10                  15      


<210>  141
<211>  18
<212>  PRT
<213>  Clostridium perfringens

<400>  141

Asn Tyr Ala Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Trp Ala 
1               5                   10                  15      


Val Ile 
        


<210>  142
<211>  22
<212>  PRT
<213>  Clostridium perfringens

<400>  142

Leu Pro Arg Arg Leu Ala Arg Gly Arg Arg Arg Leu Leu Arg Arg Lys 
1               5                   10                  15      


Ala Tyr Arg Val Glu Arg 
            20          


<210>  143
<211>  13
<212>  PRT
<213>  Clostridium perfringens

<400>  143

Pro Val Arg Ile Asn Ile Glu Leu Ala Arg Asp Leu Ala 
1               5                   10              


<210>  144
<211>  16
<212>  PRT
<213>  Clostridium perfringens

<400>  144

Lys His His Ala Leu Asp Ala Ala Val Val Gly Val Thr Thr Gln Gly 
1               5                   10                  15      


<210>  145
<211>  18
<212>  PRT
<213>  Akkermansia muciniphila

<400>  145

Ser Leu Thr Phe Ser Phe Asp Ile Gly Tyr Ala Ser Ile Gly Trp Ala 
1               5                   10                  15      


Val Ile 
        


<210>  146
<211>  13
<212>  PRT
<213>  Akkermansia muciniphila

<400>  146

Phe Lys Arg Arg Glu Tyr Arg Arg Leu Arg Arg Asn Ile 
1               5                   10              


<210>  147
<211>  13
<212>  PRT
<213>  Akkermansia muciniphila

<400>  147

Ile Ser Arg Val Cys Val Glu Val Gly Lys Glu Leu Thr 
1               5                   10              


<210>  148
<211>  16
<212>  PRT
<213>  Akkermansia muciniphila

<400>  148

Leu His His Ala Leu Asp Ala Cys Val Leu Gly Leu Ile Pro Tyr Ile 
1               5                   10                  15      


<210>  149
<211>  18
<212>  PRT
<213>  Bifidobacterium longum

<400>  149

Arg Tyr Arg Ile Gly Ile Asp Val Gly Leu Asn Ser Val Gly Leu Ala 
1               5                   10                  15      


Ala Val 
        


<210>  150
<211>  22
<212>  PRT
<213>  Bifidobacterium longum

<400>  150

Asn Met Ser Gly Val Ala Arg Arg Thr Arg Arg Met Arg Arg Arg Lys 
1               5                   10                  15      


Arg Glu Arg Leu His Lys 
            20          


<210>  151
<211>  13
<212>  PRT
<213>  Bifidobacterium longum

<400>  151

Pro Val Ser Val Asn Ile Glu His Val Arg Ser Ser Phe 
1               5                   10              


<210>  152
<211>  16
<212>  PRT
<213>  Bifidobacterium longum

<400>  152

Arg His His Ala Val Asp Ala Ser Val Ile Ala Met Met Asn Thr Ala 
1               5                   10                  15      


<210>  153
<211>  18
<212>  PRT
<213>  Wolinella succinogenes

<400>  153

Val Ser Pro Ile Ser Val Asp Leu Gly Gly Lys Asn Thr Gly Phe Phe 
1               5                   10                  15      


Ser Phe 
        


<210>  154
<211>  22
<212>  PRT
<213>  Wolinella succinogenes

<400>  154

Val Gly Arg Arg Ser Lys Arg His Ser Lys Arg Asn Asn Leu Arg Asn 
1               5                   10                  15      


Lys Leu Val Lys Arg Leu 
            20          


<210>  155
<211>  13
<212>  PRT
<213>  Wolinella succinogenes

<400>  155

Lys Val Pro Ile Ile Leu Glu Gln Asn Ala Phe Glu Tyr 
1               5                   10              


<210>  156
<211>  16
<212>  PRT
<213>  Wolinella succinogenes

<400>  156

Ser Ser His Ala Ile Asp Ala Val Met Ala Phe Val Ala Arg Tyr Gln 
1               5                   10                  15      


<210>  157
<211>  18
<212>  PRT
<213>  Legionella pneumophila

<400>  157

Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly Lys Phe Thr Gly Val Cys 
1               5                   10                  15      


Leu Ser 
        


<210>  158
<211>  22
<212>  PRT
<213>  Legionella pneumophila

<400>  158

Ala Gln Arg Arg Ala Thr Arg His Arg Val Arg Asn Lys Lys Arg Asn 
1               5                   10                  15      


Gln Phe Val Lys Arg Val 
            20          


<210>  159
<211>  13
<212>  PRT
<213>  Legionella pneumophila

<400>  159

Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu Phe 
1               5                   10              


<210>  160
<211>  15
<212>  PRT
<213>  Legionella pneumophila

<400>  160

Pro Ser His Ala Ile Asp Ala Thr Leu Thr Met Ser Ile Gly Leu 
1               5                   10                  15  


<210>  161
<211>  18
<212>  PRT
<213>  Francisella novicida

<400>  161

Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn Thr Gly Val Phe 
1               5                   10                  15      


Ser Ala 
        


<210>  162
<211>  22
<212>  PRT
<213>  Francisella novicida

<400>  162

Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly Ile Asp Arg Lys 
1               5                   10                  15      


Gln Leu Val Lys Arg Leu 
            20          


<210>  163
<211>  13
<212>  PRT
<213>  Francisella novicida

<400>  163

His Ile Pro Ile Ile Thr Glu Ser Asn Ala Phe Glu Phe 
1               5                   10              


<210>  164
<211>  16
<212>  PRT
<213>  Francisella novicida

<400>  164

Tyr Ser His Leu Ile Asp Ala Met Leu Ala Phe Cys Ile Ala Ala Asp 
1               5                   10                  15      


<210>  165
<211>  18
<212>  PRT
<213>  Streptococcus pyogenes

<400>  165

Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala 
1               5                   10                  15      


Val Ile 
        


<210>  166
<211>  22
<212>  PRT
<213>  Streptococcus pyogenes

<400>  166

Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg 
1               5                   10                  15      


Lys Asn Arg Ile Cys Tyr 
            20          


<210>  167
<211>  13
<212>  PRT
<213>  Streptococcus pyogenes

<400>  167

Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
1               5                   10              


<210>  168
<211>  16
<212>  PRT
<213>  Streptococcus pyogenes

<400>  168

Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala 
1               5                   10                  15      


<210>  169
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  169

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  170
<211>  984
<212>  PRT
<213>  Campylobacter jejuni

<400>  170

Met Ala Arg Ile Leu Ala Phe Asp Ile Gly Ile Ser Ser Ile Gly Trp 
1               5                   10                  15      


Ala Phe Ser Glu Asn Asp Glu Leu Lys Asp Cys Gly Val Arg Ile Phe 
            20                  25                  30          


Thr Lys Val Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu Pro Arg 
        35                  40                  45              


Arg Leu Ala Arg Ser Ala Arg Lys Arg Leu Ala Arg Arg Lys Ala Arg 
    50                  55                  60                  


Leu Asn His Leu Lys His Leu Ile Ala Asn Glu Phe Lys Leu Asn Tyr 
65                  70                  75                  80  


Glu Asp Tyr Gln Ser Phe Asp Glu Ser Leu Ala Lys Ala Tyr Lys Gly 
                85                  90                  95      


Ser Leu Ile Ser Pro Tyr Glu Leu Arg Phe Arg Ala Leu Asn Glu Leu 
            100                 105                 110         


Leu Ser Lys Gln Asp Phe Ala Arg Val Ile Leu His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Tyr Asp Asp Ile Lys Asn Ser Asp Asp Lys Glu Lys Gly Ala 
    130                 135                 140                 


Ile Leu Lys Ala Ile Lys Gln Asn Glu Glu Lys Leu Ala Asn Tyr Gln 
145                 150                 155                 160 


Ser Val Gly Glu Tyr Leu Tyr Lys Glu Tyr Phe Gln Lys Phe Lys Glu 
                165                 170                 175     


Asn Ser Lys Glu Phe Thr Asn Val Arg Asn Lys Lys Glu Ser Tyr Glu 
            180                 185                 190         


Arg Cys Ile Ala Gln Ser Phe Leu Lys Asp Glu Leu Lys Leu Ile Phe 
        195                 200                 205             


Lys Lys Gln Arg Glu Phe Gly Phe Ser Phe Ser Lys Lys Phe Glu Glu 
    210                 215                 220                 


Glu Val Leu Ser Val Ala Phe Tyr Lys Arg Ala Leu Lys Asp Phe Ser 
225                 230                 235                 240 


His Leu Val Gly Asn Cys Ser Phe Phe Thr Asp Glu Lys Arg Ala Pro 
                245                 250                 255     


Lys Asn Ser Pro Leu Ala Phe Met Phe Val Ala Leu Thr Arg Ile Ile 
            260                 265                 270         


Asn Leu Leu Asn Asn Leu Lys Asn Thr Glu Gly Ile Leu Tyr Thr Lys 
        275                 280                 285             


Asp Asp Leu Asn Ala Leu Leu Asn Glu Val Leu Lys Asn Gly Thr Leu 
    290                 295                 300                 


Thr Tyr Lys Gln Thr Lys Lys Leu Leu Gly Leu Ser Asp Asp Tyr Glu 
305                 310                 315                 320 


Phe Lys Gly Glu Lys Gly Thr Tyr Phe Ile Glu Phe Lys Lys Tyr Lys 
                325                 330                 335     


Glu Phe Ile Lys Ala Leu Gly Glu His Asn Leu Ser Gln Asp Asp Leu 
            340                 345                 350         


Asn Glu Ile Ala Lys Asp Ile Thr Leu Ile Lys Asp Glu Ile Lys Leu 
        355                 360                 365             


Lys Lys Ala Leu Ala Lys Tyr Asp Leu Asn Gln Asn Gln Ile Asp Ser 
    370                 375                 380                 


Leu Ser Lys Leu Glu Phe Lys Asp His Leu Asn Ile Ser Phe Lys Ala 
385                 390                 395                 400 


Leu Lys Leu Val Thr Pro Leu Met Leu Glu Gly Lys Lys Tyr Asp Glu 
                405                 410                 415     


Ala Cys Asn Glu Leu Asn Leu Lys Val Ala Ile Asn Glu Asp Lys Lys 
            420                 425                 430         


Asp Phe Leu Pro Ala Phe Asn Glu Thr Tyr Tyr Lys Asp Glu Val Thr 
        435                 440                 445             


Asn Pro Val Val Leu Arg Ala Ile Lys Glu Tyr Arg Lys Val Leu Asn 
    450                 455                 460                 


Ala Leu Leu Lys Lys Tyr Gly Lys Val His Lys Ile Asn Ile Glu Leu 
465                 470                 475                 480 


Ala Arg Glu Val Gly Lys Asn His Ser Gln Arg Ala Lys Ile Glu Lys 
                485                 490                 495     


Glu Gln Asn Glu Asn Tyr Lys Ala Lys Lys Asp Ala Glu Leu Glu Cys 
            500                 505                 510         


Glu Lys Leu Gly Leu Lys Ile Asn Ser Lys Asn Ile Leu Lys Leu Arg 
        515                 520                 525             


Leu Phe Lys Glu Gln Lys Glu Phe Cys Ala Tyr Ser Gly Glu Lys Ile 
    530                 535                 540                 


Lys Ile Ser Asp Leu Gln Asp Glu Lys Met Leu Glu Ile Asp His Ile 
545                 550                 555                 560 


Tyr Pro Tyr Ser Arg Ser Phe Asp Asp Ser Tyr Met Asn Lys Val Leu 
                565                 570                 575     


Val Phe Thr Lys Gln Asn Gln Glu Lys Leu Asn Gln Thr Pro Phe Glu 
            580                 585                 590         


Ala Phe Gly Asn Asp Ser Ala Lys Trp Gln Lys Ile Glu Val Leu Ala 
        595                 600                 605             


Lys Asn Leu Pro Thr Lys Lys Gln Lys Arg Ile Leu Asp Lys Asn Tyr 
    610                 615                 620                 


Lys Asp Lys Glu Gln Lys Asn Phe Lys Asp Arg Asn Leu Asn Asp Thr 
625                 630                 635                 640 


Arg Tyr Ile Ala Arg Leu Val Leu Asn Tyr Thr Lys Asp Tyr Leu Asp 
                645                 650                 655     


Phe Leu Pro Leu Ser Asp Asp Glu Asn Thr Lys Leu Asn Asp Thr Gln 
            660                 665                 670         


Lys Gly Ser Lys Val His Val Glu Ala Lys Ser Gly Met Leu Thr Ser 
        675                 680                 685             


Ala Leu Arg His Thr Trp Gly Phe Ser Ala Lys Asp Arg Asn Asn His 
    690                 695                 700                 


Leu His His Ala Ile Asp Ala Val Ile Ile Ala Tyr Ala Asn Asn Ser 
705                 710                 715                 720 


Ile Val Lys Ala Phe Ser Asp Phe Lys Lys Glu Gln Glu Ser Asn Ser 
                725                 730                 735     


Ala Glu Leu Tyr Ala Lys Lys Ile Ser Glu Leu Asp Tyr Lys Asn Lys 
            740                 745                 750         


Arg Lys Phe Phe Glu Pro Phe Ser Gly Phe Arg Gln Lys Val Leu Asp 
        755                 760                 765             


Lys Ile Asp Glu Ile Phe Val Ser Lys Pro Glu Arg Lys Lys Pro Ser 
    770                 775                 780                 


Gly Ala Leu His Glu Glu Thr Phe Arg Lys Glu Glu Glu Phe Tyr Gln 
785                 790                 795                 800 


Ser Tyr Gly Gly Lys Glu Gly Val Leu Lys Ala Leu Glu Leu Gly Lys 
                805                 810                 815     


Ile Arg Lys Val Asn Gly Lys Ile Val Lys Asn Gly Asp Met Phe Arg 
            820                 825                 830         


Val Asp Ile Phe Lys His Lys Lys Thr Asn Lys Phe Tyr Ala Val Pro 
        835                 840                 845             


Ile Tyr Thr Met Asp Phe Ala Leu Lys Val Leu Pro Asn Lys Ala Val 
    850                 855                 860                 


Ala Arg Ser Lys Lys Gly Glu Ile Lys Asp Trp Ile Leu Met Asp Glu 
865                 870                 875                 880 


Asn Tyr Glu Phe Cys Phe Ser Leu Tyr Lys Asp Ser Leu Ile Leu Ile 
                885                 890                 895     


Gln Thr Lys Asp Met Gln Glu Pro Glu Phe Val Tyr Tyr Asn Ala Phe 
            900                 905                 910         


Thr Ser Ser Thr Val Ser Leu Ile Val Ser Lys His Asp Asn Lys Phe 
        915                 920                 925             


Glu Thr Leu Ser Lys Asn Gln Lys Ile Leu Phe Lys Asn Ala Asn Glu 
    930                 935                 940                 


Lys Glu Val Ile Ala Lys Ser Ile Gly Ile Gln Asn Leu Lys Val Phe 
945                 950                 955                 960 


Glu Lys Tyr Ile Val Ser Ala Leu Gly Glu Val Thr Lys Ala Glu Phe 
                965                 970                 975     


Arg Gln Arg Glu Asp Phe Lys Lys 
            980                 


<210>  171
<211>  1082
<212>  PRT
<213>  Neisseria lactamica

<400>  171

Met Ala Ala Phe Lys Pro Asn Pro Met Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Lys Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Asp Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Val Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Cys Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Asn Leu Leu Phe Glu Lys Gln Lys Glu Phe Ser Asn 
    210                 215                 220                 


Pro His Val Ser Asp Ser Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Ala Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Pro Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Thr Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Lys Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Val Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Cys Lys Lys Asn Ala Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Cys Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Val 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Glu Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp His Ile Leu Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Arg Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Ala His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Ile Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Gly Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Asp Ala Leu Lys Ala Gln Leu Glu Thr His Lys 
                885                 890                 895     


Asp Asn Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Ile Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Gly Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Ala Phe Lys Asp Glu Glu Asp Trp Thr Val Met Asp 
            980                 985                 990         


Asp Ser Phe Glu Phe Arg Phe Val  Leu Tyr Ala Asn Asp  Leu Ile Lys 
        995                 1000                 1005             


Leu Thr  Ala Lys Lys Asn Glu  Phe Leu Gly Tyr Phe  Val Ser Leu 
    1010                 1015                 1020             


Asn Arg  Ala Thr Gly Ala Ile  Asp Ile Arg Thr His  Asp Thr Asp 
    1025                 1030                 1035             


Ser Thr  Lys Gly Lys Asn Gly  Ile Phe Gln Ser Val  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Asn Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  172
<211>  1082
<212>  PRT
<213>  Neisseria meningitidis

<400>  172

Met Ala Ala Phe Lys Pro Asn Ser Ile Asn Tyr Ile Leu Gly Leu Asp 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Glu 
            20                  25                  30          


Glu Asn Pro Ile Arg Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Thr Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asn 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Gly Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Ser Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Asp His Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Asn Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Leu Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210>  173
<211>  1128
<212>  PRT
<213>  Streptococcus thermophilus

<400>  173

Met Ser Asp Leu Val Leu Gly Leu Asp Ile Gly Ile Gly Ser Val Gly 
1               5                   10                  15      


Val Gly Ile Leu Asn Lys Val Thr Gly Glu Ile Ile His Lys Asn Ser 
            20                  25                  30          


Arg Ile Phe Pro Ala Ala Gln Ala Glu Asn Asn Leu Val Arg Arg Thr 
        35                  40                  45              


Asn Arg Gln Gly Arg Arg Leu Thr Arg Arg Lys Lys His Arg Ile Val 
    50                  55                  60                  


Arg Leu Asn Arg Leu Phe Glu Glu Ser Gly Leu Ile Thr Asp Phe Thr 
65                  70                  75                  80  


Lys Ile Ser Ile Asn Leu Asn Pro Tyr Gln Leu Arg Val Lys Gly Leu 
                85                  90                  95      


Thr Asp Glu Leu Ser Asn Glu Glu Leu Phe Ile Ala Leu Lys Asn Met 
            100                 105                 110         


Val Lys His Arg Gly Ile Ser Tyr Leu Asp Asp Ala Ser Asp Asp Gly 
        115                 120                 125             


Asn Ser Ser Val Gly Asp Tyr Ala Gln Ile Val Lys Glu Asn Ser Lys 
    130                 135                 140                 


Gln Leu Glu Thr Lys Thr Pro Gly Gln Ile Gln Leu Glu Arg Tyr Gln 
145                 150                 155                 160 


Thr Tyr Gly Gln Leu Arg Gly Asp Phe Thr Val Glu Lys Asp Gly Lys 
                165                 170                 175     


Lys His Arg Leu Ile Asn Val Phe Pro Thr Ser Ala Tyr Arg Ser Glu 
            180                 185                 190         


Ala Leu Arg Ile Leu Gln Thr Gln Gln Glu Phe Asn Pro Gln Ile Thr 
        195                 200                 205             


Asp Glu Phe Ile Asn Arg Tyr Leu Glu Ile Leu Thr Gly Lys Arg Lys 
    210                 215                 220                 


Tyr Tyr His Gly Pro Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Arg 
225                 230                 235                 240 


Tyr Arg Thr Ser Gly Glu Thr Leu Asp Asn Ile Phe Gly Ile Leu Ile 
                245                 250                 255     


Gly Lys Cys Thr Phe Tyr Pro Glu Glu Phe Arg Ala Ala Lys Ala Ser 
            260                 265                 270         


Tyr Thr Ala Gln Glu Phe Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr 
        275                 280                 285             


Val Pro Thr Glu Thr Lys Lys Leu Ser Lys Glu Gln Lys Asn Gln Ile 
    290                 295                 300                 


Ile Asn Tyr Val Lys Asn Glu Lys Ala Met Gly Pro Ala Lys Leu Phe 
305                 310                 315                 320 


Lys Tyr Ile Ala Lys Leu Leu Ser Cys Asp Val Ala Asp Ile Lys Gly 
                325                 330                 335     


Tyr Arg Ile Asp Lys Ser Gly Lys Ala Glu Ile His Thr Phe Glu Ala 
            340                 345                 350         


Tyr Arg Lys Met Lys Thr Leu Glu Thr Leu Asp Ile Glu Gln Met Asp 
        355                 360                 365             


Arg Glu Thr Leu Asp Lys Leu Ala Tyr Val Leu Thr Leu Asn Thr Glu 
    370                 375                 380                 


Arg Glu Gly Ile Gln Glu Ala Leu Glu His Glu Phe Ala Asp Gly Ser 
385                 390                 395                 400 


Phe Ser Gln Lys Gln Val Asp Glu Leu Val Gln Phe Arg Lys Ala Asn 
                405                 410                 415     


Ser Ser Ile Phe Gly Lys Gly Trp His Asn Phe Ser Val Lys Leu Met 
            420                 425                 430         


Met Glu Leu Ile Pro Glu Leu Tyr Glu Thr Ser Glu Glu Gln Met Thr 
        435                 440                 445             


Ile Leu Thr Arg Leu Gly Lys Gln Lys Arg Leu Arg Leu Gln Ile Lys 
    450                 455                 460                 


Gln Asn Ile Ser Asn Lys Thr Lys Tyr Ile Asp Glu Lys Leu Leu Thr 
465                 470                 475                 480 


Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Val Arg Gln Ala Ile 
                485                 490                 495     


Lys Ile Val Asn Ala Ala Ile Lys Glu Tyr Gly Asp Phe Asp Asn Ile 
            500                 505                 510         


Val Ile Glu Met Ala Arg Glu Thr Asn Glu Asp Asp Glu Lys Lys Ala 
        515                 520                 525             


Ile Gln Lys Ile Gln Lys Ala Asn Lys Asp Glu Lys Asp Ala Ala Met 
    530                 535                 540                 


Leu Lys Ala Ala Asn Gln Tyr Asn Gly Lys Ala Glu Leu Pro His Ser 
545                 550                 555                 560 


Val Phe His Gly His Lys Gln Leu Ala Thr Lys Ile Arg Leu Trp His 
                565                 570                 575     


Gln Gln Gly Glu Arg Cys Leu Tyr Thr Gly Lys Thr Ile Ser Ile His 
            580                 585                 590         


Asp Leu Ile Asn Asn Pro Asn Gln Phe Glu Val Asp His Ile Leu Pro 
        595                 600                 605             


Leu Ser Ile Thr Phe Asp Asp Ser Leu Ala Asn Lys Val Leu Val Tyr 
    610                 615                 620                 


Ala Thr Ala Asn Gln Glu Lys Gly Gln Arg Thr Pro Tyr Gln Ala Leu 
625                 630                 635                 640 


Asp Ser Met Asp Asp Ala Trp Ser Phe Arg Glu Leu Lys Ala Phe Val 
                645                 650                 655     


Arg Glu Ser Lys Thr Leu Ser Asn Lys Lys Lys Glu Tyr Leu Leu Thr 
            660                 665                 670         


Glu Glu Asp Ile Ser Lys Phe Asp Val Arg Lys Lys Phe Ile Glu Arg 
        675                 680                 685             


Asn Leu Val Asp Thr Arg Tyr Ala Ser Arg Val Val Leu Asn Ala Leu 
    690                 695                 700                 


Gln Glu His Phe Arg Ala His Lys Ile Asp Thr Lys Val Ser Val Val 
705                 710                 715                 720 


Arg Gly Gln Phe Thr Ser Gln Leu Arg Arg His Trp Gly Ile Glu Lys 
                725                 730                 735     


Thr Arg Asp Thr Tyr His His His Ala Val Asp Ala Leu Ile Ile Ala 
            740                 745                 750         


Ala Ser Ser Gln Leu Asn Leu Trp Lys Lys Gln Lys Asn Thr Leu Val 
        755                 760                 765             


Ser Tyr Ser Glu Glu Gln Leu Leu Asp Ile Glu Thr Gly Glu Leu Ile 
    770                 775                 780                 


Ser Asp Asp Glu Tyr Lys Glu Ser Val Phe Lys Ala Pro Tyr Gln His 
785                 790                 795                 800 


Phe Val Asp Thr Leu Lys Ser Lys Glu Phe Glu Asp Ser Ile Leu Phe 
                805                 810                 815     


Ser Tyr Gln Val Asp Ser Lys Phe Asn Arg Lys Ile Ser Asp Ala Thr 
            820                 825                 830         


Ile Tyr Ala Thr Arg Gln Ala Lys Val Gly Lys Asp Lys Lys Asp Glu 
        835                 840                 845             


Thr Tyr Val Leu Gly Lys Ile Lys Asp Ile Tyr Thr Gln Asp Gly Tyr 
    850                 855                 860                 


Asp Ala Phe Met Lys Ile Tyr Lys Lys Asp Lys Ser Lys Phe Leu Met 
865                 870                 875                 880 


Tyr Arg His Asp Pro Gln Thr Phe Glu Lys Val Ile Glu Pro Ile Leu 
                885                 890                 895     


Glu Asn Tyr Pro Asn Lys Gln Met Asn Glu Lys Gly Lys Glu Val Pro 
            900                 905                 910         


Cys Asn Pro Phe Leu Lys Tyr Lys Glu Glu His Gly Tyr Ile Arg Lys 
        915                 920                 925             


Tyr Ser Lys Lys Gly Asn Gly Pro Glu Ile Lys Ser Leu Lys Tyr Tyr 
    930                 935                 940                 


Asp Ser Lys Leu Leu Gly Asn Pro Ile Asp Ile Thr Pro Glu Asn Ser 
945                 950                 955                 960 


Lys Asn Lys Val Val Leu Gln Ser Leu Lys Pro Trp Arg Thr Asp Val 
                965                 970                 975     


Tyr Phe Asn Lys Ala Thr Gly Lys Tyr Glu Ile Leu Gly Leu Lys Tyr 
            980                 985                 990         


Ala Asp Leu Gln Phe Glu Lys Gly  Thr Gly Thr Tyr Lys  Ile Ser Gln 
        995                 1000                 1005             


Glu Lys  Tyr Asn Asp Ile Lys  Lys Lys Glu Gly Val  Asp Ser Asp 
    1010                 1015                 1020             


Ser Glu  Phe Lys Phe Thr Leu  Tyr Lys Asn Asp Leu  Leu Leu Val 
    1025                 1030                 1035             


Lys Asp  Thr Glu Thr Lys Glu  Gln Gln Leu Phe Arg  Phe Leu Ser 
    1040                 1045                 1050             


Arg Thr  Leu Pro Lys Gln Lys  His Tyr Val Glu Leu  Lys Pro Tyr 
    1055                 1060                 1065             


Asp Lys  Gln Lys Phe Glu Gly  Gly Glu Ala Leu Ile  Lys Val Leu 
    1070                 1075                 1080             


Gly Asn  Val Ala Asn Gly Gly  Gln Cys Ile Lys Gly  Leu Ala Lys 
    1085                 1090                 1095             


Ser Asn  Ile Ser Ile Tyr Lys  Val Arg Thr Asp Val  Leu Gly Asn 
    1100                 1105                 1110             


Gln His  Ile Ile Lys Asn Glu  Gly Asp Lys Pro Lys  Leu Asp Phe 
    1115                 1120                 1125             


<210>  174
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  174

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  175
<211>  1372
<212>  PRT
<213>  Legionella pneumophila

<400>  175

Met Glu Ser Ser Gln Ile Leu Ser Pro Ile Gly Ile Asp Leu Gly Gly 
1               5                   10                  15      


Lys Phe Thr Gly Val Cys Leu Ser His Leu Glu Ala Phe Ala Glu Leu 
            20                  25                  30          


Pro Asn His Ala Asn Thr Lys Tyr Ser Val Ile Leu Ile Asp His Asn 
        35                  40                  45              


Asn Phe Gln Leu Ser Gln Ala Gln Arg Arg Ala Thr Arg His Arg Val 
    50                  55                  60                  


Arg Asn Lys Lys Arg Asn Gln Phe Val Lys Arg Val Ala Leu Gln Leu 
65                  70                  75                  80  


Phe Gln His Ile Leu Ser Arg Asp Leu Asn Ala Lys Glu Glu Thr Ala 
                85                  90                  95      


Leu Cys His Tyr Leu Asn Asn Arg Gly Tyr Thr Tyr Val Asp Thr Asp 
            100                 105                 110         


Leu Asp Glu Tyr Ile Lys Asp Glu Thr Thr Ile Asn Leu Leu Lys Glu 
        115                 120                 125             


Leu Leu Pro Ser Glu Ser Glu His Asn Phe Ile Asp Trp Phe Leu Gln 
    130                 135                 140                 


Lys Met Gln Ser Ser Glu Phe Arg Lys Ile Leu Val Ser Lys Val Glu 
145                 150                 155                 160 


Glu Lys Lys Asp Asp Lys Glu Leu Lys Asn Ala Val Lys Asn Ile Lys 
                165                 170                 175     


Asn Phe Ile Thr Gly Phe Glu Lys Asn Ser Val Glu Gly His Arg His 
            180                 185                 190         


Arg Lys Val Tyr Phe Glu Asn Ile Lys Ser Asp Ile Thr Lys Asp Asn 
        195                 200                 205             


Gln Leu Asp Ser Ile Lys Lys Lys Ile Pro Ser Val Cys Leu Ser Asn 
    210                 215                 220                 


Leu Leu Gly His Leu Ser Asn Leu Gln Trp Lys Asn Leu His Arg Tyr 
225                 230                 235                 240 


Leu Ala Lys Asn Pro Lys Gln Phe Asp Glu Gln Thr Phe Gly Asn Glu 
                245                 250                 255     


Phe Leu Arg Met Leu Lys Asn Phe Arg His Leu Lys Gly Ser Gln Glu 
            260                 265                 270         


Ser Leu Ala Val Arg Asn Leu Ile Gln Gln Leu Glu Gln Ser Gln Asp 
        275                 280                 285             


Tyr Ile Ser Ile Leu Glu Lys Thr Pro Pro Glu Ile Thr Ile Pro Pro 
    290                 295                 300                 


Tyr Glu Ala Arg Thr Asn Thr Gly Met Glu Lys Asp Gln Ser Leu Leu 
305                 310                 315                 320 


Leu Asn Pro Glu Lys Leu Asn Asn Leu Tyr Pro Asn Trp Arg Asn Leu 
                325                 330                 335     


Ile Pro Gly Ile Ile Asp Ala His Pro Phe Leu Glu Lys Asp Leu Glu 
            340                 345                 350         


His Thr Lys Leu Arg Asp Arg Lys Arg Ile Ile Ser Pro Ser Lys Gln 
        355                 360                 365             


Asp Glu Lys Arg Asp Ser Tyr Ile Leu Gln Arg Tyr Leu Asp Leu Asn 
    370                 375                 380                 


Lys Lys Ile Asp Lys Phe Lys Ile Lys Lys Gln Leu Ser Phe Leu Gly 
385                 390                 395                 400 


Gln Gly Lys Gln Leu Pro Ala Asn Leu Ile Glu Thr Gln Lys Glu Met 
                405                 410                 415     


Glu Thr His Phe Asn Ser Ser Leu Val Ser Val Leu Ile Gln Ile Ala 
            420                 425                 430         


Ser Ala Tyr Asn Lys Glu Arg Glu Asp Ala Ala Gln Gly Ile Trp Phe 
        435                 440                 445             


Asp Asn Ala Phe Ser Leu Cys Glu Leu Ser Asn Ile Asn Pro Pro Arg 
    450                 455                 460                 


Lys Gln Lys Ile Leu Pro Leu Leu Val Gly Ala Ile Leu Ser Glu Asp 
465                 470                 475                 480 


Phe Ile Asn Asn Lys Asp Lys Trp Ala Lys Phe Lys Ile Phe Trp Asn 
                485                 490                 495     


Thr His Lys Ile Gly Arg Thr Ser Leu Lys Ser Lys Cys Lys Glu Ile 
            500                 505                 510         


Glu Glu Ala Arg Lys Asn Ser Gly Asn Ala Phe Lys Ile Asp Tyr Glu 
        515                 520                 525             


Glu Ala Leu Asn His Pro Glu His Ser Asn Asn Lys Ala Leu Ile Lys 
    530                 535                 540                 


Ile Ile Gln Thr Ile Pro Asp Ile Ile Gln Ala Ile Gln Ser His Leu 
545                 550                 555                 560 


Gly His Asn Asp Ser Gln Ala Leu Ile Tyr His Asn Pro Phe Ser Leu 
                565                 570                 575     


Ser Gln Leu Tyr Thr Ile Leu Glu Thr Lys Arg Asp Gly Phe His Lys 
            580                 585                 590         


Asn Cys Val Ala Val Thr Cys Glu Asn Tyr Trp Arg Ser Gln Lys Thr 
        595                 600                 605             


Glu Ile Asp Pro Glu Ile Ser Tyr Ala Ser Arg Leu Pro Ala Asp Ser 
    610                 615                 620                 


Val Arg Pro Phe Asp Gly Val Leu Ala Arg Met Met Gln Arg Leu Ala 
625                 630                 635                 640 


Tyr Glu Ile Ala Met Ala Lys Trp Glu Gln Ile Lys His Ile Pro Asp 
                645                 650                 655     


Asn Ser Ser Leu Leu Ile Pro Ile Tyr Leu Glu Gln Asn Arg Phe Glu 
            660                 665                 670         


Phe Glu Glu Ser Phe Lys Lys Ile Lys Gly Ser Ser Ser Asp Lys Thr 
        675                 680                 685             


Leu Glu Gln Ala Ile Glu Lys Gln Asn Ile Gln Trp Glu Glu Lys Phe 
    690                 695                 700                 


Gln Arg Ile Ile Asn Ala Ser Met Asn Ile Cys Pro Tyr Lys Gly Ala 
705                 710                 715                 720 


Ser Ile Gly Gly Gln Gly Glu Ile Asp His Ile Tyr Pro Arg Ser Leu 
                725                 730                 735     


Ser Lys Lys His Phe Gly Val Ile Phe Asn Ser Glu Val Asn Leu Ile 
            740                 745                 750         


Tyr Cys Ser Ser Gln Gly Asn Arg Glu Lys Lys Glu Glu His Tyr Leu 
        755                 760                 765             


Leu Glu His Leu Ser Pro Leu Tyr Leu Lys His Gln Phe Gly Thr Asp 
    770                 775                 780                 


Asn Val Ser Asp Ile Lys Asn Phe Ile Ser Gln Asn Val Ala Asn Ile 
785                 790                 795                 800 


Lys Lys Tyr Ile Ser Phe His Leu Leu Thr Pro Glu Gln Gln Lys Ala 
                805                 810                 815     


Ala Arg His Ala Leu Phe Leu Asp Tyr Asp Asp Glu Ala Phe Lys Thr 
            820                 825                 830         


Ile Thr Lys Phe Leu Met Ser Gln Gln Lys Ala Arg Val Asn Gly Thr 
        835                 840                 845             


Gln Lys Phe Leu Gly Lys Gln Ile Met Glu Phe Leu Ser Thr Leu Ala 
    850                 855                 860                 


Asp Ser Lys Gln Leu Gln Leu Glu Phe Ser Ile Lys Gln Ile Thr Ala 
865                 870                 875                 880 


Glu Glu Val His Asp His Arg Glu Leu Leu Ser Lys Gln Glu Pro Lys 
                885                 890                 895     


Leu Val Lys Ser Arg Gln Gln Ser Phe Pro Ser His Ala Ile Asp Ala 
            900                 905                 910         


Thr Leu Thr Met Ser Ile Gly Leu Lys Glu Phe Pro Gln Phe Ser Gln 
        915                 920                 925             


Glu Leu Asp Asn Ser Trp Phe Ile Asn His Leu Met Pro Asp Glu Val 
    930                 935                 940                 


His Leu Asn Pro Val Arg Ser Lys Glu Lys Tyr Asn Lys Pro Asn Ile 
945                 950                 955                 960 


Ser Ser Thr Pro Leu Phe Lys Asp Ser Leu Tyr Ala Glu Arg Phe Ile 
                965                 970                 975     


Pro Val Trp Val Lys Gly Glu Thr Phe Ala Ile Gly Phe Ser Glu Lys 
            980                 985                 990         


Asp Leu Phe Glu Ile Lys Pro Ser  Asn Lys Glu Lys Leu  Phe Thr Leu 
        995                 1000                 1005             


Leu Lys  Thr Tyr Ser Thr Lys  Asn Pro Gly Glu Ser  Leu Gln Glu 
    1010                 1015                 1020             


Leu Gln  Ala Lys Ser Lys Ala  Lys Trp Leu Tyr Phe  Pro Ile Asn 
    1025                 1030                 1035             


Lys Thr  Leu Ala Leu Glu Phe  Leu His His Tyr Phe  His Lys Glu 
    1040                 1045                 1050             


Ile Val  Thr Pro Asp Asp Thr  Thr Val Cys His Phe  Ile Asn Ser 
    1055                 1060                 1065             


Leu Arg  Tyr Tyr Thr Lys Lys  Glu Ser Ile Thr Val  Lys Ile Leu 
    1070                 1075                 1080             


Lys Glu  Pro Met Pro Val Leu  Ser Val Lys Phe Glu  Ser Ser Lys 
    1085                 1090                 1095             


Lys Asn  Val Leu Gly Ser Phe  Lys His Thr Ile Ala  Leu Pro Ala 
    1100                 1105                 1110             


Thr Lys  Asp Trp Glu Arg Leu  Phe Asn His Pro Asn  Phe Leu Ala 
    1115                 1120                 1125             


Leu Lys  Ala Asn Pro Ala Pro  Asn Pro Lys Glu Phe  Asn Glu Phe 
    1130                 1135                 1140             


Ile Arg  Lys Tyr Phe Leu Ser  Asp Asn Asn Pro Asn  Ser Asp Ile 
    1145                 1150                 1155             


Pro Asn  Asn Gly His Asn Ile  Lys Pro Gln Lys His  Lys Ala Val 
    1160                 1165                 1170             


Arg Lys  Val Phe Ser Leu Pro  Val Ile Pro Gly Asn  Ala Gly Thr 
    1175                 1180                 1185             


Met Met  Arg Ile Arg Arg Lys  Asp Asn Lys Gly Gln  Pro Leu Tyr 
    1190                 1195                 1200             


Gln Leu  Gln Thr Ile Asp Asp  Thr Pro Ser Met Gly  Ile Gln Ile 
    1205                 1210                 1215             


Asn Glu  Asp Arg Leu Val Lys  Gln Glu Val Leu Met  Asp Ala Tyr 
    1220                 1225                 1230             


Lys Thr  Arg Asn Leu Ser Thr  Ile Asp Gly Ile Asn  Asn Ser Glu 
    1235                 1240                 1245             


Gly Gln  Ala Tyr Ala Thr Phe  Asp Asn Trp Leu Thr  Leu Pro Val 
    1250                 1255                 1260             


Ser Thr  Phe Lys Pro Glu Ile  Ile Lys Leu Glu Met  Lys Pro His 
    1265                 1270                 1275             


Ser Lys  Thr Arg Arg Tyr Ile  Arg Ile Thr Gln Ser  Leu Ala Asp 
    1280                 1285                 1290             


Phe Ile  Lys Thr Ile Asp Glu  Ala Leu Met Ile Lys  Pro Ser Asp 
    1295                 1300                 1305             


Ser Ile  Asp Asp Pro Leu Asn  Met Pro Asn Glu Ile  Val Cys Lys 
    1310                 1315                 1320             


Asn Lys  Leu Phe Gly Asn Glu  Leu Lys Pro Arg Asp  Gly Lys Met 
    1325                 1330                 1335             


Lys Ile  Val Ser Thr Gly Lys  Ile Val Thr Tyr Glu  Phe Glu Ser 
    1340                 1345                 1350             


Asp Ser  Thr Pro Gln Trp Ile  Gln Thr Leu Tyr Val  Thr Gln Leu 
    1355                 1360                 1365             


Lys Lys  Gln Pro 
    1370         


<210>  176
<211>  1629
<212>  PRT
<213>  Francisella tularensis

<400>  176

Met Asn Phe Lys Ile Leu Pro Ile Ala Ile Asp Leu Gly Val Lys Asn 
1               5                   10                  15      


Thr Gly Val Phe Ser Ala Phe Tyr Gln Lys Gly Thr Ser Leu Glu Arg 
            20                  25                  30          


Leu Asp Asn Lys Asn Gly Lys Val Tyr Glu Leu Ser Lys Asp Ser Tyr 
        35                  40                  45              


Thr Leu Leu Met Asn Asn Arg Thr Ala Arg Arg His Gln Arg Arg Gly 
    50                  55                  60                  


Ile Asp Arg Lys Gln Leu Val Lys Arg Leu Phe Lys Leu Ile Trp Thr 
65                  70                  75                  80  


Glu Gln Leu Asn Leu Glu Trp Asp Lys Asp Thr Gln Gln Ala Ile Ser 
                85                  90                  95      


Phe Leu Phe Asn Arg Arg Gly Phe Ser Phe Ile Thr Asp Gly Tyr Ser 
            100                 105                 110         


Pro Glu Tyr Leu Asn Ile Val Pro Glu Gln Val Lys Ala Ile Leu Met 
        115                 120                 125             


Asp Ile Phe Asp Asp Tyr Asn Gly Glu Asp Asp Leu Asp Ser Tyr Leu 
    130                 135                 140                 


Lys Leu Ala Thr Glu Gln Glu Ser Lys Ile Ser Glu Ile Tyr Asn Lys 
145                 150                 155                 160 


Leu Met Gln Lys Ile Leu Glu Phe Lys Leu Met Lys Leu Cys Thr Asp 
                165                 170                 175     


Ile Lys Asp Asp Lys Val Ser Thr Lys Thr Leu Lys Glu Ile Thr Ser 
            180                 185                 190         


Tyr Glu Phe Glu Leu Leu Ala Asp Tyr Leu Ala Asn Tyr Ser Glu Ser 
        195                 200                 205             


Leu Lys Thr Gln Lys Phe Ser Tyr Thr Asp Lys Gln Gly Asn Leu Lys 
    210                 215                 220                 


Glu Leu Ser Tyr Tyr His His Asp Lys Tyr Asn Ile Gln Glu Phe Leu 
225                 230                 235                 240 


Lys Arg His Ala Thr Ile Asn Asp Arg Ile Leu Asp Thr Leu Leu Thr 
                245                 250                 255     


Asp Asp Leu Asp Ile Trp Asn Phe Asn Phe Glu Lys Phe Asp Phe Asp 
            260                 265                 270         


Lys Asn Glu Glu Lys Leu Gln Asn Gln Glu Asp Lys Asp His Ile Gln 
        275                 280                 285             


Ala His Leu His His Phe Val Phe Ala Val Asn Lys Ile Lys Ser Glu 
    290                 295                 300                 


Met Ala Ser Gly Gly Arg His Arg Ser Gln Tyr Phe Gln Glu Ile Thr 
305                 310                 315                 320 


Asn Val Leu Asp Glu Asn Asn His Gln Glu Gly Tyr Leu Lys Asn Phe 
                325                 330                 335     


Cys Glu Asn Leu His Asn Lys Lys Tyr Ser Asn Leu Ser Val Lys Asn 
            340                 345                 350         


Leu Val Asn Leu Ile Gly Asn Leu Ser Asn Leu Glu Leu Lys Pro Leu 
        355                 360                 365             


Arg Lys Tyr Phe Asn Asp Lys Ile His Ala Lys Ala Asp His Trp Asp 
    370                 375                 380                 


Glu Gln Lys Phe Thr Glu Thr Tyr Cys His Trp Ile Leu Gly Glu Trp 
385                 390                 395                 400 


Arg Val Gly Val Lys Asp Gln Asp Lys Lys Asp Gly Ala Lys Tyr Ser 
                405                 410                 415     


Tyr Lys Asp Leu Cys Asn Glu Leu Lys Gln Lys Val Thr Lys Ala Gly 
            420                 425                 430         


Leu Val Asp Phe Leu Leu Glu Leu Asp Pro Cys Arg Thr Ile Pro Pro 
        435                 440                 445             


Tyr Leu Asp Asn Asn Asn Arg Lys Pro Pro Lys Cys Gln Ser Leu Ile 
    450                 455                 460                 


Leu Asn Pro Lys Phe Leu Asp Asn Gln Tyr Pro Asn Trp Gln Gln Tyr 
465                 470                 475                 480 


Leu Gln Glu Leu Lys Lys Leu Gln Ser Ile Gln Asn Tyr Leu Asp Ser 
                485                 490                 495     


Phe Glu Thr Asp Leu Lys Val Leu Lys Ser Ser Lys Asp Gln Pro Tyr 
            500                 505                 510         


Phe Val Glu Tyr Lys Ser Ser Asn Gln Gln Ile Ala Ser Gly Gln Arg 
        515                 520                 525             


Asp Tyr Lys Asp Leu Asp Ala Arg Ile Leu Gln Phe Ile Phe Asp Arg 
    530                 535                 540                 


Val Lys Ala Ser Asp Glu Leu Leu Leu Asn Glu Ile Tyr Phe Gln Ala 
545                 550                 555                 560 


Lys Lys Leu Lys Gln Lys Ala Ser Ser Glu Leu Glu Lys Leu Glu Ser 
                565                 570                 575     


Ser Lys Lys Leu Asp Glu Val Ile Ala Asn Ser Gln Leu Ser Gln Ile 
            580                 585                 590         


Leu Lys Ser Gln His Thr Asn Gly Ile Phe Glu Gln Gly Thr Phe Leu 
        595                 600                 605             


His Leu Val Cys Lys Tyr Tyr Lys Gln Arg Gln Arg Ala Arg Asp Ser 
    610                 615                 620                 


Arg Leu Tyr Ile Met Pro Glu Tyr Arg Tyr Asp Lys Lys Leu His Lys 
625                 630                 635                 640 


Tyr Asn Asn Thr Gly Arg Phe Asp Asp Asp Asn Gln Leu Leu Thr Tyr 
                645                 650                 655     


Cys Asn His Lys Pro Arg Gln Lys Arg Tyr Gln Leu Leu Asn Asp Leu 
            660                 665                 670         


Ala Gly Val Leu Gln Val Ser Pro Asn Phe Leu Lys Asp Lys Ile Gly 
        675                 680                 685             


Ser Asp Asp Asp Leu Phe Ile Ser Lys Trp Leu Val Glu His Ile Arg 
    690                 695                 700                 


Gly Phe Lys Lys Ala Cys Glu Asp Ser Leu Lys Ile Gln Lys Asp Asn 
705                 710                 715                 720 


Arg Gly Leu Leu Asn His Lys Ile Asn Ile Ala Arg Asn Thr Lys Gly 
                725                 730                 735     


Lys Cys Glu Lys Glu Ile Phe Asn Leu Ile Cys Lys Ile Glu Gly Ser 
            740                 745                 750         


Glu Asp Lys Lys Gly Asn Tyr Lys His Gly Leu Ala Tyr Glu Leu Gly 
        755                 760                 765             


Val Leu Leu Phe Gly Glu Pro Asn Glu Ala Ser Lys Pro Glu Phe Asp 
    770                 775                 780                 


Arg Lys Ile Lys Lys Phe Asn Ser Ile Tyr Ser Phe Ala Gln Ile Gln 
785                 790                 795                 800 


Gln Ile Ala Phe Ala Glu Arg Lys Gly Asn Ala Asn Thr Cys Ala Val 
                805                 810                 815     


Cys Ser Ala Asp Asn Ala His Arg Met Gln Gln Ile Lys Ile Thr Glu 
            820                 825                 830         


Pro Val Glu Asp Asn Lys Asp Lys Ile Ile Leu Ser Ala Lys Ala Gln 
        835                 840                 845             


Arg Leu Pro Ala Ile Pro Thr Arg Ile Val Asp Gly Ala Val Lys Lys 
    850                 855                 860                 


Met Ala Thr Ile Leu Ala Lys Asn Ile Val Asp Asp Asn Trp Gln Asn 
865                 870                 875                 880 


Ile Lys Gln Val Leu Ser Ala Lys His Gln Leu His Ile Pro Ile Ile 
                885                 890                 895     


Thr Glu Ser Asn Ala Phe Glu Phe Glu Pro Ala Leu Ala Asp Val Lys 
            900                 905                 910         


Gly Lys Ser Leu Lys Asp Arg Arg Lys Lys Ala Leu Glu Arg Ile Ser 
        915                 920                 925             


Pro Glu Asn Ile Phe Lys Asp Lys Asn Asn Arg Ile Lys Glu Phe Ala 
    930                 935                 940                 


Lys Gly Ile Ser Ala Tyr Ser Gly Ala Asn Leu Thr Asp Gly Asp Phe 
945                 950                 955                 960 


Asp Gly Ala Lys Glu Glu Leu Asp His Ile Ile Pro Arg Ser His Lys 
                965                 970                 975     


Lys Tyr Gly Thr Leu Asn Asp Glu Ala Asn Leu Ile Cys Val Thr Arg 
            980                 985                 990         


Gly Asp Asn Lys Asn Lys Gly Asn  Arg Ile Phe Cys Leu  Arg Asp Leu 
        995                 1000                 1005             


Ala Asp  Asn Tyr Lys Leu Lys  Gln Phe Glu Thr Thr  Asp Asp Leu 
    1010                 1015                 1020             


Glu Ile  Glu Lys Lys Ile Ala  Asp Thr Ile Trp Asp  Ala Asn Lys 
    1025                 1030                 1035             


Lys Asp  Phe Lys Phe Gly Asn  Tyr Arg Ser Phe Ile  Asn Leu Thr 
    1040                 1045                 1050             


Pro Gln  Glu Gln Lys Ala Phe  Arg His Ala Leu Phe  Leu Ala Asp 
    1055                 1060                 1065             


Glu Asn  Pro Ile Lys Gln Ala  Val Ile Arg Ala Ile  Asn Asn Arg 
    1070                 1075                 1080             


Asn Arg  Thr Phe Val Asn Gly  Thr Gln Arg Tyr Phe  Ala Glu Val 
    1085                 1090                 1095             


Leu Ala  Asn Asn Ile Tyr Leu  Arg Ala Lys Lys Glu  Asn Leu Asn 
    1100                 1105                 1110             


Thr Asp  Lys Ile Ser Phe Asp  Tyr Phe Gly Ile Pro  Thr Ile Gly 
    1115                 1120                 1125             


Asn Gly  Arg Gly Ile Ala Glu  Ile Arg Gln Leu Tyr  Glu Lys Val 
    1130                 1135                 1140             


Asp Ser  Asp Ile Gln Ala Tyr  Ala Lys Gly Asp Lys  Pro Gln Ala 
    1145                 1150                 1155             


Ser Tyr  Ser His Leu Ile Asp  Ala Met Leu Ala Phe  Cys Ile Ala 
    1160                 1165                 1170             


Ala Asp  Glu His Arg Asn Asp  Gly Ser Ile Gly Leu  Glu Ile Asp 
    1175                 1180                 1185             


Lys Asn  Tyr Ser Leu Tyr Pro  Leu Asp Lys Asn Thr  Gly Glu Val 
    1190                 1195                 1200             


Phe Thr  Lys Asp Ile Phe Ser  Gln Ile Lys Ile Thr  Asp Asn Glu 
    1205                 1210                 1215             


Phe Ser  Asp Lys Lys Leu Val  Arg Lys Lys Ala Ile  Glu Gly Phe 
    1220                 1225                 1230             


Asn Thr  His Arg Gln Met Thr  Arg Asp Gly Ile Tyr  Ala Glu Asn 
    1235                 1240                 1245             


Tyr Leu  Pro Ile Leu Ile His  Lys Glu Leu Asn Glu  Val Arg Lys 
    1250                 1255                 1260             


Gly Tyr  Thr Trp Lys Asn Ser  Glu Glu Ile Lys Ile  Phe Lys Gly 
    1265                 1270                 1275             


Lys Lys  Tyr Asp Ile Gln Gln  Leu Asn Asn Leu Val  Tyr Cys Leu 
    1280                 1285                 1290             


Lys Phe  Val Asp Lys Pro Ile  Ser Ile Asp Ile Gln  Ile Ser Thr 
    1295                 1300                 1305             


Leu Glu  Glu Leu Arg Asn Ile  Leu Thr Thr Asn Asn  Ile Ala Ala 
    1310                 1315                 1320             


Thr Ala  Glu Tyr Tyr Tyr Ile  Asn Leu Lys Thr Gln  Lys Leu His 
    1325                 1330                 1335             


Glu Tyr  Tyr Ile Glu Asn Tyr  Asn Thr Ala Leu Gly  Tyr Lys Lys 
    1340                 1345                 1350             


Tyr Ser  Lys Glu Met Glu Phe  Leu Arg Ser Leu Ala  Tyr Arg Ser 
    1355                 1360                 1365             


Glu Arg  Val Lys Ile Lys Ser  Ile Asp Asp Val Lys  Gln Val Leu 
    1370                 1375                 1380             


Asp Lys  Asp Ser Asn Phe Ile  Ile Gly Lys Ile Thr  Leu Pro Phe 
    1385                 1390                 1395             


Lys Lys  Glu Trp Gln Arg Leu  Tyr Arg Glu Trp Gln  Asn Thr Thr 
    1400                 1405                 1410             


Ile Lys  Asp Asp Tyr Glu Phe  Leu Lys Ser Phe Phe  Asn Val Lys 
    1415                 1420                 1425             


Ser Ile  Thr Lys Leu His Lys  Lys Val Arg Lys Asp  Phe Ser Leu 
    1430                 1435                 1440             


Pro Ile  Ser Thr Asn Glu Gly  Lys Phe Leu Val Lys  Arg Lys Thr 
    1445                 1450                 1455             


Trp Asp  Asn Asn Phe Ile Tyr  Gln Ile Leu Asn Asp  Ser Asp Ser 
    1460                 1465                 1470             


Arg Ala  Asp Gly Thr Lys Pro  Phe Ile Pro Ala Phe  Asp Ile Ser 
    1475                 1480                 1485             


Lys Asn  Glu Ile Val Glu Ala  Ile Ile Asp Ser Phe  Thr Ser Lys 
    1490                 1495                 1500             


Asn Ile  Phe Trp Leu Pro Lys  Asn Ile Glu Leu Gln  Lys Val Asp 
    1505                 1510                 1515             


Asn Lys  Asn Ile Phe Ala Ile  Asp Thr Ser Lys Trp  Phe Glu Val 
    1520                 1525                 1530             


Glu Thr  Pro Ser Asp Leu Arg  Asp Ile Gly Ile Ala  Thr Ile Gln 
    1535                 1540                 1545             


Tyr Lys  Ile Asp Asn Asn Ser  Arg Pro Lys Val Arg  Val Lys Leu 
    1550                 1555                 1560             


Asp Tyr  Val Ile Asp Asp Asp  Ser Lys Ile Asn Tyr  Phe Met Asn 
    1565                 1570                 1575             


His Ser  Leu Leu Lys Ser Arg  Tyr Pro Asp Lys Val  Leu Glu Ile 
    1580                 1585                 1590             


Leu Lys  Gln Ser Thr Ile Ile  Glu Phe Glu Ser Ser  Gly Phe Asn 
    1595                 1600                 1605             


Lys Thr  Ile Lys Glu Met Leu  Gly Met Lys Leu Ala  Gly Ile Tyr 
    1610                 1615                 1620             


Asn Glu  Thr Ser Asn Asn 
    1625                 


<210>  177
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  Cas12a.1 pre-crRNA

<400>  177
guuuaaggcc uugacaaaau uucuacugua guagau                                 36


<210>  178
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  Cas12p pre-crRNA

<400>  178
aucuacaaaa guagaaaucu aauagggaua uuggag                                 36


<210>  179
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  Cas12p pre-crRNA

<400>  179
cucgaauauc ccuauuagau uucuacuuuu guagau                                 36


<210>  180
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  Cas12q pre-crRNA

<400>  180
aucuacaaaa guagaaauua aauaggucua uuugag                                 36


<210>  181
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  Cas12q pre-crRNA

<400>  181
cucaaauaga ccuauuuaau uucuacuuuu guagau                                 36


<210>  182
<211>  18
<212>  PRT
<213>  Candidatus Methanomethylophilus alvus

<400>  182

Leu Lys Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Val 
1               5                   10                  15      


Thr Met 
        


<210>  183
<211>  22
<212>  PRT
<213>  Candidatus Methanomethylophilus alvus

<400>  183

Arg Lys Ala Leu Asp Val Arg Glu Tyr Asp Asn Lys Glu Ala Arg Arg 
1               5                   10                  15      


Asn Trp Thr Lys Val Glu 
            20          


<210>  184
<211>  13
<212>  PRT
<213>  Candidatus Methanomethylophilus alvus

<400>  184

Asn Ala Ile Ile Val Met Glu Asp Leu Asn His Gly Phe 
1               5                   10              


<210>  185
<211>  16
<212>  PRT
<213>  Candidatus Methanomethylophilus alvus

<400>  185

Leu Pro Gln Asp Ser Asp Ala Asn Gly Ala Tyr Asn Ile Ala Leu Lys 
1               5                   10                  15      


<210>  186
<211>  18
<212>  PRT
<213>  Synergistes jonesii

<400>  186

Val Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Val Tyr Val 
1               5                   10                  15      


Ser Leu 
        


<210>  187
<211>  22
<212>  PRT
<213>  Synergistes jonesii

<400>  187

His Ala Lys Leu Asn Gln Lys Glu Lys Glu Arg Asp Thr Ala Arg Lys 
1               5                   10                  15      


Ser Trp Lys Thr Ile Gly 
            20          


<210>  188
<211>  13
<212>  PRT
<213>  Synergistes jonesii

<400>  188

Asn Ala Val Ile Val Met Glu Asp Leu Asn Ile Gly Phe 
1               5                   10              


<210>  189
<211>  16
<212>  PRT
<213>  Synergistes jonesii

<400>  189

Leu Pro Ile Asp Ala Asp Ala Asn Gly Ala Tyr His Ile Ala Leu Lys 
1               5                   10                  15      


<210>  190
<211>  18
<212>  PRT
<213>  Lachnospiraceae bacterium ND2006

<400>  190

Pro Tyr Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile 
1               5                   10                  15      


Val Val 
        


<210>  191
<211>  22
<212>  PRT
<213>  Lachnospiraceae bacterium ND2006

<400>  191

His Ser Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln 
1               5                   10                  15      


Asn Trp Thr Ser Ile Glu 
            20          


<210>  192
<211>  13
<212>  PRT
<213>  Lachnospiraceae bacterium ND2006

<400>  192

Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser Gly Phe 
1               5                   10              


<210>  193
<211>  16
<212>  PRT
<213>  Lachnospiraceae bacterium ND2006

<400>  193

Leu Pro Lys Asn Ala Asp Ala Asn Gly Ala Tyr Asn Ile Ala Arg Lys 
1               5                   10                  15      


<210>  194
<211>  18
<212>  PRT
<213>  Francisella tularensis

<400>  194

Val His Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr 
1               5                   10                  15      


Thr Leu 
        


<210>  195
<211>  22
<212>  PRT
<213>  Francisella tularensis

<400>  195

His Asp Lys Leu Ala Ala Ile Glu Lys Asp Arg Asp Ser Ala Arg Lys 
1               5                   10                  15      


Asp Trp Lys Lys Ile Asn 
            20          


<210>  196
<211>  13
<212>  PRT
<213>  Francisella tularensis

<400>  196

Asn Ala Ile Val Val Phe Glu Asp Leu Asn Phe Gly Phe 
1               5                   10              


<210>  197
<211>  16
<212>  PRT
<213>  Francisella tularensis

<400>  197

Met Pro Gln Asp Ala Asp Ala Asn Gly Ala Tyr His Ile Gly Leu Lys 
1               5                   10                  15      


<210>  198
<211>  18
<212>  PRT
<213>  Moraxella caprae

<400>  198

Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu 
1               5                   10                  15      


Thr Val 
        


<210>  199
<211>  22
<212>  PRT
<213>  Moraxella caprae

<400>  199

His Lys Ile Leu Asp Lys Arg Glu Ile Glu Arg Leu Asn Ala Arg Val 
1               5                   10                  15      


Gly Trp Gly Glu Ile Glu 
            20          


<210>  200
<211>  13
<212>  PRT
<213>  Moraxella caprae

<400>  200

Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe 
1               5                   10              


<210>  201
<211>  16
<212>  PRT
<213>  Moraxella caprae

<400>  201

Gln Pro Gln Asn Ala Asp Ala Asn Gly Ala Tyr His Ile Ala Leu Lys 
1               5                   10                  15      


<210>  202
<211>  18
<212>  PRT
<213>  Lachnospiraceae bacterium MD335

<400>  202

Met His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Leu 
1               5                   10                  15      


Cys Met 
        


<210>  203
<211>  22
<212>  PRT
<213>  Lachnospiraceae bacterium MD335

<400>  203

His Gln Leu Leu Lys Thr Arg Glu Asp Glu Asn Lys Ser Ala Arg Gln 
1               5                   10                  15      


Ser Trp Gln Thr Ile His 
            20          


<210>  204
<211>  13
<212>  PRT
<213>  Lachnospiraceae bacterium MD335

<400>  204

Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe 
1               5                   10              


<210>  205
<211>  16
<212>  PRT
<213>  Lachnospiraceae bacterium MD335

<400>  205

Met Pro Leu Asp Ala Asp Ala Asn Gly Ala Tyr Asn Ile Ala Arg Lys 
1               5                   10                  15      


<210>  206
<211>  18
<212>  PRT
<213>  Prevotella albensis

<400>  206

Thr His Ile Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu 
1               5                   10                  15      


Ser Leu 
        


<210>  207
<211>  22
<212>  PRT
<213>  Prevotella albensis

<400>  207

His Asn Leu Leu Glu Lys Arg Glu Lys Glu Arg Thr Glu Ala Arg His 
1               5                   10                  15      


Ser Trp Ser Ser Ile Glu 
            20          


<210>  208
<211>  13
<212>  PRT
<213>  Prevotella albensis

<400>  208

Asn Ala Ile Val Val Leu Glu Asp Leu Asn Gly Gly Phe 
1               5                   10              


<210>  209
<211>  16
<212>  PRT
<213>  Prevotella albensis

<400>  209

Phe Pro Glu Asn Ala Asp Ala Asn Gly Ala Tyr Asn Ile Ala Arg Lys 
1               5                   10                  15      


<210>  210
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  Smithella sp.

<400>  210

Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Tyr 
1               5                   10                  15      


Ala Leu 
        


<210>  211
<211>  22
<212>  PRT
<213>  Unknown

<220>
<223>  Smithella sp.

<400>  211

His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr Ala Arg Gln 
1               5                   10                  15      


Glu Trp Gly Val Ile Glu 
            20          


<210>  212
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Smithella sp.

<400>  212

Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe 
1               5                   10              


<210>  213
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Smithella sp.

<400>  213

Met Pro Lys Asn Ala Asp Ala Asn Gly Ala Tyr His Ile Ala Leu Lys 
1               5                   10                  15      


<210>  214
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  Porphyromonas sp.

<400>  214

Met His Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile 
1               5                   10                  15      


Cys Val 
        


<210>  215
<211>  22
<212>  PRT
<213>  Unknown

<220>
<223>  Porphyromonas sp.

<400>  215

His Asp Leu Leu Glu Ser Arg Asp Lys Asp Arg Gln Gln Glu Arg Arg 
1               5                   10                  15      


Asn Trp Gln Thr Ile Glu 
            20          


<210>  216
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Porphyromonas sp.

<400>  216

Lys Ala Val Val Ala Leu Glu Asp Leu Asn Met Gly Phe 
1               5                   10              


<210>  217
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Porphyromonas sp.

<400>  217

Leu Pro Lys Asp Ala Asp Ala Asn Gly Ala Tyr Asn Ile Ala Leu Lys 
1               5                   10                  15      


<210>  218
<211>  1300
<212>  PRT
<213>  Francisella tularensis

<400>  218

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asp Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Val Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Asp Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Leu Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Glu Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Arg Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Asn Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Glu Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu His Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Asp Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  219
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  219

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  220
<211>  767
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12g1

<400>  220

Met Ala Gln Ala Ser Ser Thr Pro Ala Val Ser Pro Arg Pro Arg Pro 
1               5                   10                  15      


Arg Tyr Arg Glu Glu Arg Thr Leu Val Arg Lys Leu Leu Pro Arg Pro 
            20                  25                  30          


Gly Gln Ser Lys Gln Glu Phe Arg Glu Asn Val Lys Lys Leu Arg Lys 
        35                  40                  45              


Ala Phe Leu Gln Phe Asn Ala Asp Val Ser Gly Val Cys Gln Trp Ala 
    50                  55                  60                  


Ile Gln Phe Arg Pro Arg Tyr Gly Lys Pro Ala Glu Pro Thr Glu Thr 
65                  70                  75                  80  


Phe Trp Lys Phe Phe Leu Glu Pro Glu Thr Ser Leu Pro Pro Asn Asp 
                85                  90                  95      


Ser Arg Ser Pro Glu Phe Arg Arg Leu Gln Ala Phe Glu Ala Ala Ala 
            100                 105                 110         


Gly Ile Asn Gly Ala Ala Ala Leu Asp Asp Pro Ala Phe Thr Asn Glu 
        115                 120                 125             


Leu Arg Asp Ser Ile Leu Ala Val Ala Ser Arg Pro Lys Thr Lys Glu 
    130                 135                 140                 


Ala Gln Arg Leu Phe Ser Arg Leu Lys Asp Tyr Gln Pro Ala His Arg 
145                 150                 155                 160 


Met Ile Leu Ala Lys Val Ala Ala Glu Trp Ile Glu Ser Arg Tyr Arg 
                165                 170                 175     


Arg Ala His Gln Asn Trp Glu Arg Asn Tyr Glu Glu Trp Lys Lys Glu 
            180                 185                 190         


Lys Gln Glu Trp Glu Gln Asn His Pro Glu Leu Thr Pro Glu Ile Arg 
        195                 200                 205             


Glu Ala Phe Asn Gln Ile Phe Gln Gln Leu Glu Val Lys Glu Lys Arg 
    210                 215                 220                 


Val Arg Ile Cys Pro Ala Ala Arg Leu Leu Gln Asn Lys Asp Asn Cys 
225                 230                 235                 240 


Gln Tyr Ala Gly Lys Asn Lys His Ser Val Leu Cys Asn Gln Phe Asn 
                245                 250                 255     


Glu Phe Lys Lys Asn His Leu Gln Gly Lys Ala Ile Lys Phe Phe Tyr 
            260                 265                 270         


Lys Asp Ala Glu Lys Tyr Leu Arg Cys Gly Leu Gln Ser Leu Lys Pro 
        275                 280                 285             


Asn Val Gln Gly Pro Phe Arg Glu Asp Trp Asn Lys Tyr Leu Arg Tyr 
    290                 295                 300                 


Met Asn Leu Lys Glu Glu Thr Leu Arg Gly Lys Asn Gly Gly Arg Leu 
305                 310                 315                 320 


Pro His Cys Lys Asn Leu Gly Gln Glu Cys Glu Phe Asn Pro His Thr 
                325                 330                 335     


Ala Leu Cys Lys Gln Tyr Gln Gln Gln Leu Ser Ser Arg Pro Asp Leu 
            340                 345                 350         


Val Gln His Asp Glu Leu Tyr Arg Lys Trp Arg Arg Glu Tyr Trp Arg 
        355                 360                 365             


Glu Pro Arg Lys Pro Val Phe Arg Tyr Pro Ser Val Lys Arg His Ser 
    370                 375                 380                 


Ile Ala Lys Ile Phe Gly Glu Asn Tyr Phe Gln Ala Asp Phe Lys Asn 
385                 390                 395                 400 


Ser Val Val Gly Leu Arg Leu Asp Ser Met Pro Ala Gly Gln Tyr Leu 
                405                 410                 415     


Glu Phe Ala Phe Ala Pro Trp Pro Arg Asn Tyr Arg Pro Gln Pro Gly 
            420                 425                 430         


Glu Thr Glu Ile Ser Ser Val His Leu His Phe Val Gly Thr Arg Pro 
        435                 440                 445             


Arg Ile Gly Phe Arg Phe Arg Val Pro His Lys Arg Ser Arg Phe Asp 
    450                 455                 460                 


Cys Thr Gln Glu Glu Leu Asp Glu Leu Arg Ser Arg Thr Phe Pro Arg 
465                 470                 475                 480 


Lys Ala Gln Asp Gln Lys Phe Leu Glu Ala Ala Arg Lys Arg Leu Leu 
                485                 490                 495     


Glu Thr Phe Pro Gly Asn Ala Glu Gln Glu Leu Arg Leu Leu Ala Val 
            500                 505                 510         


Asp Leu Gly Thr Asp Ser Ala Arg Ala Ala Phe Phe Ile Gly Lys Thr 
        515                 520                 525             


Phe Gln Gln Ala Phe Pro Leu Lys Ile Val Lys Ile Glu Lys Leu Tyr 
    530                 535                 540                 


Glu Gln Trp Pro Asn Gln Lys Gln Ala Gly Asp Arg Arg Asp Ala Ser 
545                 550                 555                 560 


Ser Lys Gln Pro Arg Pro Gly Leu Ser Arg Asp His Val Gly Arg His 
                565                 570                 575     


Leu Gln Lys Met Arg Ala Gln Ala Ser Glu Ile Ala Gln Lys Arg Gln 
            580                 585                 590         


Glu Leu Thr Gly Thr Pro Ala Pro Glu Thr Thr Thr Asp Gln Ala Ala 
        595                 600                 605             


Lys Lys Ala Thr Leu Gln Pro Phe Asp Leu Arg Gly Leu Thr Val His 
    610                 615                 620                 


Thr Ala Arg Met Ile Arg Asp Trp Ala Arg Leu Asn Ala Arg Gln Ile 
625                 630                 635                 640 


Ile Gln Leu Ala Glu Glu Asn Gln Val Asp Leu Ile Val Leu Glu Ser 
                645                 650                 655     


Leu Arg Gly Phe Arg Pro Pro Gly Tyr Glu Asn Leu Asp Gln Glu Lys 
            660                 665                 670         


Lys Arg Arg Val Ala Phe Phe Ala His Gly Arg Ile Arg Arg Lys Val 
        675                 680                 685             


Thr Glu Lys Ala Val Glu Arg Gly Met Arg Val Val Thr Val Pro Tyr 
    690                 695                 700                 


Leu Ala Ser Ser Lys Val Cys Ala Glu Cys Arg Lys Lys Gln Lys Asp 
705                 710                 715                 720 


Asn Lys Gln Trp Glu Lys Asn Lys Lys Arg Gly Leu Phe Lys Cys Glu 
                725                 730                 735     


Gly Cys Gly Ser Gln Ala Gln Val Asp Glu Asn Ala Ala Arg Val Leu 
            740                 745                 750         


Gly Arg Val Phe Trp Gly Glu Ile Glu Leu Pro Thr Ala Ile Pro 
        755                 760                 765         


<210>  221
<211>  1300
<212>  PRT
<213>  Francisella tularensis subsp. novicida U112

<400>  221

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  222
<211>  1046
<212>  PRT
<213>  Unknown

<220>
<223>  Cas12p truncated

<400>  222

Asn Ser Ile Asp Lys Val Phe Ser Val Ile Phe Tyr Ser Ser Cys Leu 
1               5                   10                  15      


Leu Gln Glu Gly Ile Asp Phe Tyr Asn Cys Val Leu Gly Gly Glu Thr 
            20                  25                  30          


Leu Pro Asn Gly Glu Lys Arg Gln Gly Ile Asn Glu Leu Ile Asn Leu 
        35                  40                  45              


Tyr Arg Gln Lys Thr Ser Glu Lys Val Pro Phe Leu Lys Leu Leu Asp 
    50                  55                  60                  


Lys Gln Ile Leu Ser Glu Lys Glu Lys Phe Met Asp Glu Ile Glu Asn 
65                  70                  75                  80  


Asp Glu Ala Leu Leu Asp Thr Leu Lys Ile Phe Arg Lys Ser Ala Glu 
                85                  90                  95      


Glu Lys Thr Thr Leu Leu Lys Asn Ile Phe Gly Asp Phe Val Met Asn 
            100                 105                 110         


Gln Gly Lys Tyr Asp Leu Ala Gln Ile Tyr Ile Ser Arg Glu Ser Leu 
        115                 120                 125             


Asn Thr Ile Ser Arg Lys Trp Thr Ser Glu Thr Asp Ile Phe Glu Asp 
    130                 135                 140                 


Ser Leu Tyr Glu Val Leu Lys Lys Ser Lys Ile Val Ser Ala Ser Val 
145                 150                 155                 160 


Lys Lys Lys Asp Gly Gly Tyr Ala Phe Pro Glu Phe Ile Ala Leu Ile 
                165                 170                 175     


Tyr Val Lys Ser Ala Leu Glu Gln Ile Pro Thr Glu Lys Phe Trp Lys 
            180                 185                 190         


Glu Arg Tyr Tyr Lys Asn Ile Gly Asp Val Leu Asn Lys Gly Phe Leu 
        195                 200                 205             


Asn Gly Lys Glu Gly Val Trp Leu Gln Phe Leu Leu Ile Phe Asp Phe 
    210                 215                 220                 


Glu Phe Asn Ser Leu Phe Glu Arg Glu Ile Ile Asp Glu Asn Gly Asp 
225                 230                 235                 240 


Lys Lys Val Ala Gly Tyr Asn Leu Phe Ala Lys Gly Phe Asp Asp Leu 
                245                 250                 255     


Leu Asn Asn Phe Lys Tyr Asp Gln Lys Ala Lys Val Val Ile Lys Asp 
            260                 265                 270         


Phe Ala Asp Glu Val Leu His Ile Tyr Gln Met Gly Lys Tyr Phe Ala 
        275                 280                 285             


Ile Glu Lys Lys Arg Ser Trp Leu Ala Asp Tyr Asp Ile Asp Ser Phe 
    290                 295                 300                 


Tyr Thr Asp Pro Glu Lys Gly Tyr Leu Lys Phe Tyr Glu Asn Ala Tyr 
305                 310                 315                 320 


Glu Glu Ile Ile Gln Val Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys 
                325                 330                 335     


Lys Pro Tyr Ser Glu Asp Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr 
            340                 345                 350         


Leu Ala Asp Gly Trp Asp Lys Asn Lys Glu Ala Asp Asn Ser Thr Val 
        355                 360                 365             


Ile Leu Lys Lys Asp Gly Arg Tyr Tyr Leu Gly Leu Met Ala Arg Gly 
    370                 375                 380                 


Arg Asn Lys Leu Phe Asp Asp Arg Asn Leu Pro Lys Ile Leu Glu Gly 
385                 390                 395                 400 


Val Glu Asn Gly Lys Tyr Glu Lys Val Val Tyr Lys Tyr Phe Pro Asp 
                405                 410                 415     


Gln Ala Lys Met Phe Pro Lys Val Cys Phe Ser Thr Lys Gly Leu Glu 
            420                 425                 430         


Phe Phe Gln Pro Ser Glu Glu Val Ile Thr Ile Tyr Lys Asn Ser Glu 
        435                 440                 445             


Phe Lys Lys Gly Tyr Thr Phe Asn Val Arg Ser Met Gln Arg Leu Ile 
    450                 455                 460                 


Asp Phe Tyr Lys Asp Cys Leu Val Arg Tyr Glu Gly Trp Gln Cys Tyr 
465                 470                 475                 480 


Asp Phe Arg Asn Leu Arg Lys Thr Glu Asp Tyr Arg Lys Asn Ile Glu 
                485                 490                 495     


Glu Phe Phe Ser Asp Val Ala Met Asp Gly Tyr Lys Ile Ser Phe Gln 
            500                 505                 510         


Asp Val Ser Glu Ser Tyr Ile Lys Glu Lys Asn Gln Asn Gly Asp Leu 
        515                 520                 525             


Tyr Leu Phe Glu Ile Lys Asn Lys Asp Trp Asn Glu Gly Ala Asn Gly 
    530                 535                 540                 


Lys Lys Asn Leu His Thr Ile Tyr Phe Glu Ser Leu Phe Ser Ala Asp 
545                 550                 555                 560 


Asn Ile Ala Met Asn Phe Pro Val Lys Leu Asn Gly Gln Ala Glu Ile 
                565                 570                 575     


Phe Tyr Arg Pro Arg Thr Glu Gly Leu Glu Lys Glu Arg Ile Ile Thr 
            580                 585                 590         


Lys Lys Gly Asn Val Leu Glu Lys Gly Asp Lys Ala Phe His Lys Arg 
        595                 600                 605             


Arg Tyr Thr Glu Asn Lys Val Phe Phe His Val Pro Ile Thr Leu Asn 
    610                 615                 620                 


Arg Thr Lys Lys Asn Pro Phe Gln Phe Asn Ala Lys Ile Asn Asp Phe 
625                 630                 635                 640 


Leu Ala Lys Asn Ser Asp Ile Asn Val Ile Gly Val Asp Arg Gly Glu 
                645                 650                 655     


Lys Gln Leu Ala Tyr Phe Ser Val Ile Ser Gln Arg Gly Lys Ile Leu 
            660                 665                 670         


Asp Arg Gly Ser Leu Asn Val Ile Asn Gly Val Asn Tyr Ala Glu Lys 
        675                 680                 685             


Leu Glu Glu Lys Ala Arg Gly Arg Glu Gln Ala Arg Lys Asp Trp Gln 
    690                 695                 700                 


Gln Ile Glu Gly Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser Gln Val 
705                 710                 715                 720 


Val Arg Lys Leu Ala Asp Leu Ala Ile Gln Tyr Asn Ala Ile Ile Val 
                725                 730                 735     


Phe Glu Asp Leu Asn Met Arg Phe Lys Gln Ile Arg Gly Gly Ile Glu 
            740                 745                 750         


Lys Ser Val Tyr Gln Gln Leu Glu Lys Ala Leu Ile Asp Lys Leu Thr 
        755                 760                 765             


Phe Leu Val Glu Lys Glu Glu Lys Asp Val Glu Lys Ala Gly His Leu 
    770                 775                 780                 


Leu Lys Ala Tyr Gln Leu Ala Ala Pro Phe Glu Thr Phe Gln Lys Met 
785                 790                 795                 800 


Gly Lys Gln Thr Gly Ile Val Phe Tyr Thr Gln Ala Ala Tyr Thr Ser 
                805                 810                 815     


Arg Ile Asp Pro Val Thr Gly Trp Arg Pro His Leu Tyr Leu Lys Tyr 
            820                 825                 830         


Ser Ser Ala Glu Lys Ala Lys Ala Asp Leu Leu Lys Phe Lys Lys Ile 
        835                 840                 845             


Lys Phe Val Asp Gly Arg Phe Glu Phe Thr Tyr Asp Ile Lys Ser Phe 
    850                 855                 860                 


Arg Glu Gln Lys Glu His Pro Lys Ala Thr Val Trp Thr Val Cys Ser 
865                 870                 875                 880 


Cys Val Glu Arg Phe Arg Trp Asn Arg Tyr Leu Asn Ser Asn Lys Gly 
                885                 890                 895     


Gly Tyr Asp His Tyr Ser Asp Val Thr Lys Phe Leu Val Glu Leu Phe 
            900                 905                 910         


Gln Glu Tyr Gly Ile Asp Phe Glu Arg Gly Asp Ile Val Gly Gln Ile 
        915                 920                 925             


Glu Val Leu Glu Thr Lys Gly Asn Glu Lys Phe Phe Lys Asn Phe Val 
    930                 935                 940                 


Phe Phe Phe Asn Leu Ile Cys Gln Ile Arg Asn Thr Asn Ala Ser Glu 
945                 950                 955                 960 


Leu Ala Lys Lys Asp Gly Lys Asp Asp Phe Ile Leu Ser Pro Val Glu 
                965                 970                 975     


Pro Phe Phe Asp Ser Arg Asn Ser Glu Lys Phe Gly Glu Asp Leu Pro 
            980                 985                 990         


Lys Asn Gly Asp Asp Asn Gly Ala  Phe Asn Ile Ala Arg  Lys Gly Leu 
        995                 1000                 1005             


Val Ile  Met Asp Lys Ile Thr  Lys Phe Ala Asp Glu  Asn Gly Gly 
    1010                 1015                 1020             


Cys Glu  Lys Met Lys Trp Gly  Asp Leu Tyr Val Ser  Asn Val Glu 
    1025                 1030                 1035             


Trp Asp  Asn Phe Val Ala Asn  Lys 
    1040                 1045     


<210>  223
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp. BV3L6

<400>  223

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  224
<211>  1206
<212>  PRT
<213>  Lachnospiraceae bacterium MA2020

<400>  224

Met Tyr Tyr Glu Ser Leu Thr Lys Gln Tyr Pro Val Ser Lys Thr Ile 
1               5                   10                  15      


Arg Asn Glu Leu Ile Pro Ile Gly Lys Thr Leu Asp Asn Ile Arg Gln 
            20                  25                  30          


Asn Asn Ile Leu Glu Ser Asp Val Lys Arg Lys Gln Asn Tyr Glu His 
        35                  40                  45              


Val Lys Gly Ile Leu Asp Glu Tyr His Lys Gln Leu Ile Asn Glu Ala 
    50                  55                  60                  


Leu Asp Asn Cys Thr Leu Pro Ser Leu Lys Ile Ala Ala Glu Ile Tyr 
65                  70                  75                  80  


Leu Lys Asn Gln Lys Glu Val Ser Asp Arg Glu Asp Phe Asn Lys Thr 
                85                  90                  95      


Gln Asp Leu Leu Arg Lys Glu Val Val Glu Lys Leu Lys Ala His Glu 
            100                 105                 110         


Asn Phe Thr Lys Ile Gly Lys Lys Asp Ile Leu Asp Leu Leu Glu Lys 
        115                 120                 125             


Leu Pro Ser Ile Ser Glu Asp Asp Tyr Asn Ala Leu Glu Ser Phe Arg 
    130                 135                 140                 


Asn Phe Tyr Thr Tyr Phe Thr Ser Tyr Asn Lys Val Arg Glu Asn Leu 
145                 150                 155                 160 


Tyr Ser Asp Lys Glu Lys Ser Ser Thr Val Ala Tyr Arg Leu Ile Asn 
                165                 170                 175     


Glu Asn Phe Pro Lys Phe Leu Asp Asn Val Lys Ser Tyr Arg Phe Val 
            180                 185                 190         


Lys Thr Ala Gly Ile Leu Ala Asp Gly Leu Gly Glu Glu Glu Gln Asp 
        195                 200                 205             


Ser Leu Phe Ile Val Glu Thr Phe Asn Lys Thr Leu Thr Gln Asp Gly 
    210                 215                 220                 


Ile Asp Thr Tyr Asn Ser Gln Val Gly Lys Ile Asn Ser Ser Ile Asn 
225                 230                 235                 240 


Leu Tyr Asn Gln Lys Asn Gln Lys Ala Asn Gly Phe Arg Lys Ile Pro 
                245                 250                 255     


Lys Met Lys Met Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Glu Ser 
            260                 265                 270         


Phe Ile Asp Glu Phe Gln Ser Asp Glu Val Leu Ile Asp Asn Val Glu 
        275                 280                 285             


Ser Tyr Gly Ser Val Leu Ile Glu Ser Leu Lys Ser Ser Lys Val Ser 
    290                 295                 300                 


Ala Phe Phe Asp Ala Leu Arg Glu Ser Lys Gly Lys Asn Val Tyr Val 
305                 310                 315                 320 


Lys Asn Asp Leu Ala Lys Thr Ala Met Ser Asn Ile Val Phe Glu Asn 
                325                 330                 335     


Trp Arg Thr Phe Asp Asp Leu Leu Asn Gln Glu Tyr Asp Leu Ala Asn 
            340                 345                 350         


Glu Asn Lys Lys Lys Asp Asp Lys Tyr Phe Glu Lys Arg Gln Lys Glu 
        355                 360                 365             


Leu Lys Lys Asn Lys Ser Tyr Ser Leu Glu His Leu Cys Asn Leu Ser 
    370                 375                 380                 


Glu Asp Ser Cys Asn Leu Ile Glu Asn Tyr Ile His Gln Ile Ser Asp 
385                 390                 395                 400 


Asp Ile Glu Asn Ile Ile Ile Asn Asn Glu Thr Phe Leu Arg Ile Val 
                405                 410                 415     


Ile Asn Glu His Asp Arg Ser Arg Lys Leu Ala Lys Asn Arg Lys Ala 
            420                 425                 430         


Val Lys Ala Ile Lys Asp Phe Leu Asp Ser Ile Lys Val Leu Glu Arg 
        435                 440                 445             


Glu Leu Lys Leu Ile Asn Ser Ser Gly Gln Glu Leu Glu Lys Asp Leu 
    450                 455                 460                 


Ile Val Tyr Ser Ala His Glu Glu Leu Leu Val Glu Leu Lys Gln Val 
465                 470                 475                 480 


Asp Ser Leu Tyr Asn Met Thr Arg Asn Tyr Leu Thr Lys Lys Pro Phe 
                485                 490                 495     


Ser Thr Glu Lys Val Lys Leu Asn Phe Asn Arg Ser Thr Leu Leu Asn 
            500                 505                 510         


Gly Trp Asp Arg Asn Lys Glu Thr Asp Asn Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Lys Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Thr Ser Ala Asn Lys 
    530                 535                 540                 


Ala Phe Val Asn Pro Pro Val Ala Lys Thr Glu Lys Val Phe Lys Lys 
545                 550                 555                 560 


Val Asp Tyr Lys Leu Leu Pro Val Pro Asn Gln Met Leu Pro Lys Val 
                565                 570                 575     


Phe Phe Ala Lys Ser Asn Ile Asp Phe Tyr Asn Pro Ser Ser Glu Ile 
            580                 585                 590         


Tyr Ser Asn Tyr Lys Lys Gly Thr His Lys Lys Gly Asn Met Phe Ser 
        595                 600                 605             


Leu Glu Asp Cys His Asn Leu Ile Asp Phe Phe Lys Glu Ser Ile Ser 
    610                 615                 620                 


Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Ser Asp Thr Ala 
625                 630                 635                 640 


Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val Glu Lys Gln Gly 
                645                 650                 655     


Tyr Lys Leu Thr Tyr Thr Asp Ile Asp Glu Thr Tyr Ile Asn Asp Leu 
            660                 665                 670         


Ile Glu Arg Asn Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
        675                 680                 685             


Ser Met Tyr Ser Lys Gly Lys Leu Asn Leu His Thr Leu Tyr Phe Met 
    690                 695                 700                 


Met Leu Phe Asp Gln Arg Asn Ile Asp Asp Val Val Tyr Lys Leu Asn 
705                 710                 715                 720 


Gly Glu Ala Glu Val Phe Tyr Arg Pro Ala Ser Ile Ser Glu Asp Glu 
                725                 730                 735     


Leu Ile Ile His Lys Ala Gly Glu Glu Ile Lys Asn Lys Asn Pro Asn 
            740                 745                 750         


Arg Ala Arg Thr Lys Glu Thr Ser Thr Phe Ser Tyr Asp Ile Val Lys 
        755                 760                 765             


Asp Lys Arg Tyr Ser Lys Asp Lys Phe Thr Leu His Ile Pro Ile Thr 
    770                 775                 780                 


Met Asn Phe Gly Val Asp Glu Val Lys Arg Phe Asn Asp Ala Val Asn 
785                 790                 795                 800 


Ser Ala Ile Arg Ile Asp Glu Asn Val Asn Val Ile Gly Ile Asp Arg 
                805                 810                 815     


Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Ser Lys Gly Asn 
            820                 825                 830         


Ile Leu Glu Gln Ile Ser Leu Asn Ser Ile Ile Asn Lys Glu Tyr Asp 
        835                 840                 845             


Ile Glu Thr Asp Tyr His Ala Leu Leu Asp Glu Arg Glu Gly Gly Arg 
    850                 855                 860                 


Asp Lys Ala Arg Lys Asp Trp Asn Thr Val Glu Asn Ile Arg Asp Leu 
865                 870                 875                 880 


Lys Ala Gly Tyr Leu Ser Gln Val Val Asn Val Val Ala Lys Leu Val 
                885                 890                 895     


Leu Lys Tyr Asn Ala Ile Ile Cys Leu Glu Asp Leu Asn Phe Gly Phe 
            900                 905                 910         


Lys Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu 
        915                 920                 925             


Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Ile Asp Lys Ser Arg 
    930                 935                 940                 


Glu Gln Thr Ser Pro Lys Glu Leu Gly Gly Ala Leu Asn Ala Leu Gln 
945                 950                 955                 960 


Leu Thr Ser Lys Phe Lys Ser Phe Lys Glu Leu Gly Lys Gln Ser Gly 
                965                 970                 975     


Val Ile Tyr Tyr Val Pro Ala Tyr Leu Thr Ser Lys Ile Asp Pro Thr 
            980                 985                 990         


Thr Gly Phe Ala Asn Leu Phe Tyr  Met Lys Cys Glu Asn  Val Glu Lys 
        995                 1000                 1005             


Ser Lys  Arg Phe Phe Asp Gly  Phe Asp Phe Ile Arg  Phe Asn Ala 
    1010                 1015                 1020             


Leu Glu  Asn Val Phe Glu Phe  Gly Phe Asp Tyr Arg  Ser Phe Thr 
    1025                 1030                 1035             


Gln Arg  Ala Cys Gly Ile Asn  Ser Lys Trp Thr Val  Cys Thr Asn 
    1040                 1045                 1050             


Gly Glu  Arg Ile Ile Lys Tyr  Arg Asn Pro Asp Lys  Asn Asn Met 
    1055                 1060                 1065             


Phe Asp  Glu Lys Val Val Val  Val Thr Asp Glu Met  Lys Asn Leu 
    1070                 1075                 1080             


Phe Glu  Gln Tyr Lys Ile Pro  Tyr Glu Asp Gly Arg  Asn Val Lys 
    1085                 1090                 1095             


Asp Met  Ile Ile Ser Asn Glu  Glu Ala Glu Phe Tyr  Arg Arg Leu 
    1100                 1105                 1110             


Tyr Arg  Leu Leu Gln Gln Thr  Leu Gln Met Arg Asn  Ser Thr Ser 
    1115                 1120                 1125             


Asp Gly  Thr Arg Asp Tyr Ile  Ile Ser Pro Val Lys  Asn Lys Arg 
    1130                 1135                 1140             


Glu Ala  Tyr Phe Asn Ser Glu  Leu Ser Asp Gly Ser  Val Pro Lys 
    1145                 1150                 1155             


Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu 
    1160                 1165                 1170             


Trp Val  Leu Glu Gln Ile Arg  Gln Lys Ser Glu Gly  Glu Lys Ile 
    1175                 1180                 1185             


Asn Leu  Ala Met Thr Asn Ala  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1190                 1195                 1200             


His Leu  Leu 
    1205     


<210>  225
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12a.1 variant A

<400>  225
uaggugaugu caccuuuaaa acaguuccgg aauuug                                 36


<210>  226
<211>  37
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12a.1 variant B

<400>  226
gguuuaaggc cuugacaaaa uuucuccugu aggagau                                37


<210>  227
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12a.1 variant C

<400>  227
uaggggaugu ccccuuuaaa acaguuccgg aauuug                                 36


<210>  228
<211>  37
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12p variant A

<400>  228
uagguguuuu caccuuuaga uuagcccuau aagcucg                                37


<210>  229
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12p variant B

<400>  229
uagagguuuu ccucuuuaga uuaucccuau aagcuc                                 36


<210>  230
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12p variant C

<400>  230
uagccguuuu cggcuuuaga uuaucccuau aagcuc                                 36


<210>  231
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12p variant D

<400>  231
gagcuuacag ggauaaucug aagaugaaaa caugua                                 36


<210>  232
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12p variant E

<400>  232
gagcuuaucg ggauaaucga aagaugaaaa caucua                                 36


<210>  233
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12p variant F

<400>  233
gagcuuaccg ggauaaucgg aagaugaaaa caucua                                 36


<210>  234
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12q variant A

<400>  234
uagguguuuu caccuuuaau uuauccagau aaacuc                                 36


<210>  235
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12q variant B

<400>  235
uagagguuuu ccucuuuaau uuauccagau aaacuc                                 36


<210>  236
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12q variant C

<400>  236
uagggguuuu ccccuuuaau uuauccagau aaacuc                                 36


<210>  237
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12q variant D

<400>  237
gagcuuaucu ggauaaguua aagaugaaaa caucua                                 36


<210>  238
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12q variant E

<400>  238
gaguuucucu ggagaaauua aagaugaaaa caucua                                 36


<210>  239
<211>  36
<212>  RNA
<213>  Unknown

<220>
<223>  direct repeat for guide for Cas12q variant F

<400>  239
gagcccaucu ggauggguua aagaugaaaa caucua                                 36


<210>  240
<211>  1227
<212>  PRT
<213>  Candidatus Methanomethylophilus alvus

<400>  240

Met Asp Ala Lys Glu Phe Thr Gly Gln Tyr Pro Leu Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Arg Pro Ile Gly Arg Thr Trp Asp Asn Leu Glu Ala 
            20                  25                  30          


Ser Gly Tyr Leu Ala Glu Asp Arg His Arg Ala Glu Cys Tyr Pro Arg 
        35                  40                  45              


Ala Lys Glu Leu Leu Asp Asp Asn His Arg Ala Phe Leu Asn Arg Val 
    50                  55                  60                  


Leu Pro Gln Ile Asp Met Asp Trp His Pro Ile Ala Glu Ala Phe Cys 
65                  70                  75                  80  


Lys Val His Lys Asn Pro Gly Asn Lys Glu Leu Ala Gln Asp Tyr Asn 
                85                  90                  95      


Leu Gln Leu Ser Lys Arg Arg Lys Glu Ile Ser Ala Tyr Leu Gln Asp 
            100                 105                 110         


Ala Asp Gly Tyr Lys Gly Leu Phe Ala Lys Pro Ala Leu Asp Glu Ala 
        115                 120                 125             


Met Lys Ile Ala Lys Glu Asn Gly Asn Glu Ser Asp Ile Glu Val Leu 
    130                 135                 140                 


Glu Ala Phe Asn Gly Phe Ser Val Tyr Phe Thr Gly Tyr His Glu Ser 
145                 150                 155                 160 


Arg Glu Asn Ile Tyr Ser Asp Glu Asp Met Val Ser Val Ala Tyr Arg 
                165                 170                 175     


Ile Thr Glu Asp Asn Phe Pro Arg Phe Val Ser Asn Ala Leu Ile Phe 
            180                 185                 190         


Asp Lys Leu Asn Glu Ser His Pro Asp Ile Ile Ser Glu Val Ser Gly 
        195                 200                 205             


Asn Leu Gly Val Asp Asp Ile Gly Lys Tyr Phe Asp Val Ser Asn Tyr 
    210                 215                 220                 


Asn Asn Phe Leu Ser Gln Ala Gly Ile Asp Asp Tyr Asn His Ile Ile 
225                 230                 235                 240 


Gly Gly His Thr Thr Glu Asp Gly Leu Ile Gln Ala Phe Asn Val Val 
                245                 250                 255     


Leu Asn Leu Arg His Gln Lys Asp Pro Gly Phe Glu Lys Ile Gln Phe 
            260                 265                 270         


Lys Gln Leu Tyr Lys Gln Ile Leu Ser Val Arg Thr Ser Lys Ser Tyr 
        275                 280                 285             


Ile Pro Lys Gln Phe Asp Asn Ser Lys Glu Met Val Asp Cys Ile Cys 
    290                 295                 300                 


Asp Tyr Val Ser Lys Ile Glu Lys Ser Glu Thr Val Glu Arg Ala Leu 
305                 310                 315                 320 


Lys Leu Val Arg Asn Ile Ser Ser Phe Asp Leu Arg Gly Ile Phe Val 
                325                 330                 335     


Asn Lys Lys Asn Leu Arg Ile Leu Ser Asn Lys Leu Ile Gly Asp Trp 
            340                 345                 350         


Asp Ala Ile Glu Thr Ala Leu Met His Ser Ser Ser Ser Glu Asn Asp 
        355                 360                 365             


Lys Lys Ser Val Tyr Asp Ser Ala Glu Ala Phe Thr Leu Asp Asp Ile 
    370                 375                 380                 


Phe Ser Ser Val Lys Lys Phe Ser Asp Ala Ser Ala Glu Asp Ile Gly 
385                 390                 395                 400 


Asn Arg Ala Glu Asp Ile Cys Arg Val Ile Ser Glu Thr Ala Pro Phe 
                405                 410                 415     


Ile Asn Asp Leu Arg Ala Val Asp Leu Asp Ser Leu Asn Asp Asp Gly 
            420                 425                 430         


Tyr Glu Ala Ala Val Ser Lys Ile Arg Glu Ser Leu Glu Pro Tyr Met 
        435                 440                 445             


Asp Leu Phe His Glu Leu Glu Ile Phe Ser Val Gly Asp Glu Phe Pro 
    450                 455                 460                 


Lys Cys Ala Ala Phe Tyr Ser Glu Leu Glu Glu Val Ser Glu Gln Leu 
465                 470                 475                 480 


Ile Glu Ile Ile Pro Leu Phe Asn Lys Ala Arg Ser Phe Cys Thr Arg 
                485                 490                 495     


Lys Arg Tyr Ser Thr Asp Lys Ile Lys Val Asn Leu Lys Phe Pro Thr 
            500                 505                 510         


Leu Ala Asp Gly Trp Asp Leu Asn Lys Glu Arg Asp Asn Lys Ala Ala 
        515                 520                 525             


Ile Leu Arg Lys Asp Gly Lys Tyr Tyr Leu Ala Ile Leu Asp Met Lys 
    530                 535                 540                 


Lys Asp Leu Ser Ser Ile Arg Thr Ser Asp Glu Asp Glu Ser Ser Phe 
545                 550                 555                 560 


Glu Lys Met Glu Tyr Lys Leu Leu Pro Ser Pro Val Lys Met Leu Pro 
                565                 570                 575     


Lys Ile Phe Val Lys Ser Lys Ala Ala Lys Glu Lys Tyr Gly Leu Thr 
            580                 585                 590         


Asp Arg Met Leu Glu Cys Tyr Asp Lys Gly Met His Lys Ser Gly Ser 
        595                 600                 605             


Ala Phe Asp Leu Gly Phe Cys His Glu Leu Ile Asp Tyr Tyr Lys Arg 
    610                 615                 620                 


Cys Ile Ala Glu Tyr Pro Gly Trp Asp Val Phe Asp Phe Lys Phe Arg 
625                 630                 635                 640 


Glu Thr Ser Asp Tyr Gly Ser Met Lys Glu Phe Asn Glu Asp Val Ala 
                645                 650                 655     


Gly Ala Gly Tyr Tyr Met Ser Leu Arg Lys Ile Pro Cys Ser Glu Val 
            660                 665                 670         


Tyr Arg Leu Leu Asp Glu Lys Ser Ile Tyr Leu Phe Gln Ile Tyr Asn 
        675                 680                 685             


Lys Asp Tyr Ser Glu Asn Ala His Gly Asn Lys Asn Met His Thr Met 
    690                 695                 700                 


Tyr Trp Glu Gly Leu Phe Ser Pro Gln Asn Leu Glu Ser Pro Val Phe 
705                 710                 715                 720 


Lys Leu Ser Gly Gly Ala Glu Leu Phe Phe Arg Lys Ser Ser Ile Pro 
                725                 730                 735     


Asn Asp Ala Lys Thr Val His Pro Lys Gly Ser Val Leu Val Pro Arg 
            740                 745                 750         


Asn Asp Val Asn Gly Arg Arg Ile Pro Asp Ser Ile Tyr Arg Glu Leu 
        755                 760                 765             


Thr Arg Tyr Phe Asn Arg Gly Asp Cys Arg Ile Ser Asp Glu Ala Lys 
    770                 775                 780                 


Ser Tyr Leu Asp Lys Val Lys Thr Lys Lys Ala Asp His Asp Ile Val 
785                 790                 795                 800 


Lys Asp Arg Arg Phe Thr Val Asp Lys Met Met Phe His Val Pro Ile 
                805                 810                 815     


Ala Met Asn Phe Lys Ala Ile Ser Lys Pro Asn Leu Asn Lys Lys Val 
            820                 825                 830         


Ile Asp Gly Ile Ile Asp Asp Gln Asp Leu Lys Ile Ile Gly Ile Asp 
        835                 840                 845             


Arg Gly Glu Arg Asn Leu Ile Tyr Val Thr Met Val Asp Arg Lys Gly 
    850                 855                 860                 


Asn Ile Leu Tyr Gln Asp Ser Leu Asn Ile Leu Asn Gly Tyr Asp Tyr 
865                 870                 875                 880 


Arg Lys Ala Leu Asp Val Arg Glu Tyr Asp Asn Lys Glu Ala Arg Arg 
                885                 890                 895     


Asn Trp Thr Lys Val Glu Gly Ile Arg Lys Met Lys Glu Gly Tyr Leu 
            900                 905                 910         


Ser Leu Ala Val Ser Lys Leu Ala Asp Met Ile Ile Glu Asn Asn Ala 
        915                 920                 925             


Ile Ile Val Met Glu Asp Leu Asn His Gly Phe Lys Ala Gly Arg Ser 
    930                 935                 940                 


Lys Ile Glu Lys Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn 
945                 950                 955                 960 


Lys Leu Gly Tyr Met Val Leu Lys Asp Lys Ser Ile Asp Gln Ser Gly 
                965                 970                 975     


Gly Ala Leu His Gly Tyr Gln Leu Ala Asn His Val Thr Thr Leu Ala 
            980                 985                 990         


Ser Val Gly Lys Gln Cys Gly Val  Ile Phe Tyr Ile Pro  Ala Ala Phe 
        995                 1000                 1005             


Thr Ser  Lys Ile Asp Pro Thr  Thr Gly Phe Ala Asp  Leu Phe Ala 
    1010                 1015                 1020             


Leu Ser  Asn Val Lys Asn Val  Ala Ser Met Arg Glu  Phe Phe Ser 
    1025                 1030                 1035             


Lys Met  Lys Ser Val Ile Tyr  Asp Lys Ala Glu Gly  Lys Phe Ala 
    1040                 1045                 1050             


Phe Thr  Phe Asp Tyr Leu Asp  Tyr Asn Val Lys Ser  Glu Cys Gly 
    1055                 1060                 1065             


Arg Thr  Leu Trp Thr Val Tyr  Thr Val Gly Glu Arg  Phe Thr Tyr 
    1070                 1075                 1080             


Ser Arg  Val Asn Arg Glu Tyr  Val Arg Lys Val Pro  Thr Asp Ile 
    1085                 1090                 1095             


Ile Tyr  Asp Ala Leu Gln Lys  Ala Gly Ile Ser Val  Glu Gly Asp 
    1100                 1105                 1110             


Leu Arg  Asp Arg Ile Ala Glu  Ser Asp Gly Asp Thr  Leu Lys Ser 
    1115                 1120                 1125             


Ile Phe  Tyr Ala Phe Lys Tyr  Ala Leu Asp Met Arg  Val Glu Asn 
    1130                 1135                 1140             


Arg Glu  Glu Asp Tyr Ile Gln  Ser Pro Val Lys Asn  Ala Ser Gly 
    1145                 1150                 1155             


Glu Phe  Phe Cys Ser Lys Asn  Ala Gly Lys Ser Leu  Pro Gln Asp 
    1160                 1165                 1170             


Ser Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Lys  Gly Ile Leu 
    1175                 1180                 1185             


Gln Leu  Arg Met Leu Ser Glu  Gln Tyr Asp Pro Asn  Ala Glu Ser 
    1190                 1195                 1200             


Ile Arg  Leu Pro Leu Ile Thr  Asn Lys Ala Trp Leu  Thr Phe Met 
    1205                 1210                 1215             


Gln Ser  Gly Met Lys Thr Trp  Lys Asn 
    1220                 1225         


<210>  241
<211>  1259
<212>  PRT
<213>  Synergistes jonesii

<400>  241

Met Ala Asn Ser Leu Lys Asp Phe Thr Asn Ile Tyr Gln Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Glu Glu His Ile 
            20                  25                  30          


Asn Arg Lys Leu Ile Ile Met His Asp Glu Lys Arg Gly Glu Asp Tyr 
        35                  40                  45              


Lys Ser Val Thr Lys Leu Ile Asp Asp Tyr His Arg Lys Phe Ile His 
    50                  55                  60                  


Glu Thr Leu Asp Pro Ala His Phe Asp Trp Asn Pro Leu Ala Glu Ala 
65                  70                  75                  80  


Leu Ile Gln Ser Gly Ser Lys Asn Asn Lys Ala Leu Pro Ala Glu Gln 
                85                  90                  95      


Lys Glu Met Arg Glu Lys Ile Ile Ser Met Phe Thr Ser Gln Ala Val 
            100                 105                 110         


Tyr Lys Lys Leu Phe Lys Lys Glu Leu Phe Ser Glu Leu Leu Pro Glu 
        115                 120                 125             


Met Ile Lys Ser Glu Leu Val Ser Asp Leu Glu Lys Gln Ala Gln Leu 
    130                 135                 140                 


Asp Ala Val Lys Ser Phe Asp Lys Phe Ser Thr Tyr Phe Thr Gly Phe 
145                 150                 155                 160 


His Glu Asn Arg Lys Asn Ile Tyr Ser Lys Lys Asp Thr Ser Thr Ser 
                165                 170                 175     


Ile Ala Phe Arg Ile Val His Gln Asn Phe Pro Lys Phe Leu Ala Asn 
            180                 185                 190         


Val Arg Ala Tyr Thr Leu Ile Lys Glu Arg Ala Pro Glu Val Ile Asp 
        195                 200                 205             


Lys Ala Gln Lys Glu Leu Ser Gly Ile Leu Gly Gly Lys Thr Leu Asp 
    210                 215                 220                 


Asp Ile Phe Ser Ile Glu Ser Phe Asn Asn Val Leu Thr Gln Asp Lys 
225                 230                 235                 240 


Ile Asp Tyr Tyr Asn Gln Ile Ile Gly Gly Val Ser Gly Lys Ala Gly 
                245                 250                 255     


Asp Lys Lys Leu Arg Gly Val Asn Glu Phe Ser Asn Leu Tyr Arg Gln 
            260                 265                 270         


Gln His Pro Glu Val Ala Ser Leu Arg Ile Lys Met Val Pro Leu Tyr 
        275                 280                 285             


Lys Gln Ile Leu Ser Asp Arg Thr Thr Leu Ser Phe Val Pro Glu Ala 
    290                 295                 300                 


Leu Lys Asp Asp Glu Gln Ala Ile Asn Ala Val Asp Gly Leu Arg Ser 
305                 310                 315                 320 


Glu Leu Glu Arg Asn Asp Ile Phe Asn Arg Ile Lys Arg Leu Phe Gly 
                325                 330                 335     


Lys Asn Asn Leu Tyr Ser Leu Asp Lys Ile Trp Ile Lys Asn Ser Ser 
            340                 345                 350         


Ile Ser Ala Phe Ser Asn Glu Leu Phe Lys Asn Trp Ser Phe Ile Glu 
        355                 360                 365             


Asp Ala Leu Lys Glu Phe Lys Glu Asn Glu Phe Asn Gly Ala Arg Ser 
    370                 375                 380                 


Ala Gly Lys Lys Ala Glu Lys Trp Leu Lys Ser Lys Tyr Phe Ser Phe 
385                 390                 395                 400 


Ala Asp Ile Asp Ala Ala Val Lys Ser Tyr Ser Glu Gln Val Ser Ala 
                405                 410                 415     


Asp Ile Ser Ser Ala Pro Ser Ala Ser Tyr Phe Ala Lys Phe Thr Asn 
            420                 425                 430         


Leu Ile Glu Thr Ala Ala Glu Asn Gly Arg Lys Phe Ser Tyr Phe Ala 
        435                 440                 445             


Ala Glu Ser Lys Ala Phe Arg Gly Asp Asp Gly Lys Thr Glu Ile Ile 
    450                 455                 460                 


Lys Ala Tyr Leu Asp Ser Leu Asn Asp Ile Leu His Cys Leu Lys Pro 
465                 470                 475                 480 


Phe Glu Thr Glu Asp Ile Ser Asp Ile Asp Thr Glu Phe Tyr Ser Ala 
                485                 490                 495     


Phe Ala Glu Ile Tyr Asp Ser Val Lys Asp Val Ile Pro Val Tyr Asn 
            500                 505                 510         


Ala Val Arg Asn Tyr Thr Thr Gln Lys Pro Phe Ser Thr Glu Lys Phe 
        515                 520                 525             


Lys Leu Asn Phe Glu Asn Pro Ala Leu Ala Lys Gly Trp Asp Lys Asn 
    530                 535                 540                 


Lys Glu Gln Asn Asn Thr Ala Ile Ile Leu Met Lys Asp Gly Lys Tyr 
545                 550                 555                 560 


Tyr Leu Gly Val Ile Asp Lys Asn Asn Lys Leu Arg Ala Asp Asp Leu 
                565                 570                 575     


Ala Asp Asp Gly Ser Ala Tyr Gly Tyr Met Lys Met Asn Tyr Lys Phe 
            580                 585                 590         


Ile Pro Thr Pro His Met Glu Leu Pro Lys Val Phe Leu Pro Lys Arg 
        595                 600                 605             


Ala Pro Lys Arg Tyr Asn Pro Ser Arg Glu Ile Leu Leu Ile Lys Glu 
    610                 615                 620                 


Asn Lys Thr Phe Ile Lys Asp Lys Asn Phe Asn Arg Thr Asp Cys His 
625                 630                 635                 640 


Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Asn Lys His Lys Asp Trp 
                645                 650                 655     


Arg Thr Phe Gly Phe Asp Phe Ser Asp Thr Asp Ser Tyr Glu Asp Ile 
            660                 665                 670         


Ser Asp Phe Tyr Met Glu Val Gln Asp Gln Gly Tyr Lys Leu Thr Phe 
        675                 680                 685             


Thr Arg Leu Ser Ala Glu Lys Ile Asp Lys Trp Val Glu Glu Gly Arg 
    690                 695                 700                 


Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Asp Gly Ala Gln 
705                 710                 715                 720 


Gly Ser Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Lys Asp Val Val Leu Lys Leu Asn Gly Glu Ala Glu Leu 
            740                 745                 750         


Phe Phe Arg Arg Lys Ser Ile Asp Lys Pro Ala Val His Ala Lys Gly 
        755                 760                 765             


Ser Met Lys Val Asn Arg Arg Asp Ile Asp Gly Asn Pro Ile Asp Glu 
    770                 775                 780                 


Gly Thr Tyr Val Glu Ile Cys Gly Tyr Ala Asn Gly Lys Arg Asp Met 
785                 790                 795                 800 


Ala Ser Leu Asn Ala Gly Ala Arg Gly Leu Ile Glu Ser Gly Leu Val 
                805                 810                 815     


Arg Ile Thr Glu Val Lys His Glu Leu Val Lys Asp Lys Arg Tyr Thr 
            820                 825                 830         


Ile Asp Lys Tyr Phe Phe His Val Pro Phe Thr Ile Asn Phe Lys Ala 
        835                 840                 845             


Gln Gly Gln Gly Asn Ile Asn Ser Asp Val Asn Leu Phe Leu Arg Asn 
    850                 855                 860                 


Asn Lys Asp Val Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
865                 870                 875                 880 


Val Tyr Val Ser Leu Ile Asp Arg Asp Gly His Ile Lys Leu Gln Lys 
                885                 890                 895     


Asp Phe Asn Ile Ile Gly Gly Met Asp Tyr His Ala Lys Leu Asn Gln 
            900                 905                 910         


Lys Glu Lys Glu Arg Asp Thr Ala Arg Lys Ser Trp Lys Thr Ile Gly 
        915                 920                 925             


Thr Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu 
    930                 935                 940                 


Ile Val Arg Leu Ala Val Asp Asn Asn Ala Val Ile Val Met Glu Asp 
945                 950                 955                 960 


Leu Asn Ile Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Val 
                965                 970                 975     


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val 
            980                 985                 990         


Phe Lys Asp Ala Gly Tyr Asp Ala  Pro Cys Gly Ile Leu  Lys Gly Leu 
        995                 1000                 1005             


Gln Leu  Thr Glu Lys Phe Glu  Ser Phe Thr Lys Leu  Gly Lys Gln 
    1010                 1015                 1020             


Cys Gly  Ile Ile Phe Tyr Ile  Pro Ala Gly Tyr Thr  Ser Lys Ile 
    1025                 1030                 1035             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Ile  Asn Asp Val 
    1040                 1045                 1050             


Ser Ser  Lys Glu Lys Gln Lys  Asp Phe Ile Gly Lys  Leu Asp Ser 
    1055                 1060                 1065             


Ile Arg  Phe Asp Ala Lys Arg  Asp Met Phe Thr Phe  Glu Phe Asp 
    1070                 1075                 1080             


Tyr Asp  Lys Phe Arg Thr Tyr  Gln Thr Ser Tyr Arg  Lys Lys Trp 
    1085                 1090                 1095             


Ala Val  Trp Thr Asn Gly Lys  Arg Ile Val Arg Glu  Lys Asp Lys 
    1100                 1105                 1110             


Asp Gly  Lys Phe Arg Met Asn  Asp Arg Leu Leu Thr  Glu Asp Met 
    1115                 1120                 1125             


Lys Asn  Ile Leu Asn Lys Tyr  Ala Leu Ala Tyr Lys  Ala Gly Glu 
    1130                 1135                 1140             


Asp Ile  Leu Pro Asp Val Ile  Ser Arg Asp Lys Ser  Leu Ala Ser 
    1145                 1150                 1155             


Glu Ile  Phe Tyr Val Phe Lys  Asn Thr Leu Gln Met  Arg Asn Ser 
    1160                 1165                 1170             


Lys Arg  Asp Thr Gly Glu Asp  Phe Ile Ile Ser Pro  Val Leu Asn 
    1175                 1180                 1185             


Ala Lys  Gly Arg Phe Phe Asp  Ser Arg Lys Thr Asp  Ala Ala Leu 
    1190                 1195                 1200             


Pro Ile  Asp Ala Asp Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys 
    1205                 1210                 1215             


Gly Ser  Leu Val Leu Asp Ala  Ile Asp Glu Lys Leu  Lys Glu Asp 
    1220                 1225                 1230             


Gly Arg  Ile Asp Tyr Lys Asp  Met Ala Val Ser Asn  Pro Lys Trp 
    1235                 1240                 1245             


Phe Glu  Phe Met Gln Thr Arg  Lys Phe Asp Phe 
    1250                 1255                 


<210>  242
<211>  1228
<212>  PRT
<213>  Lachnospiraceae bacterium ND2006

<400>  242

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  243
<211>  1300
<212>  PRT
<213>  Francisella tularensis

<400>  243

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  244
<211>  632
<212>  PRT
<213>  Moraxella bovoculi

<400>  244

Lys Arg Tyr Asn Pro Ser Gln Asp Leu Val Asp Gln Tyr Asn Ile Tyr 
1               5                   10                  15      


Lys Lys Ile Asp Ser Asn Asp Asn Arg Lys Lys Glu Asn Phe Tyr Asn 
            20                  25                  30          


Asn His Pro Lys Phe Lys Lys Asp Leu Val Arg Tyr Tyr Tyr Glu Ser 
        35                  40                  45              


Met Cys Lys His Glu Glu Trp Glu Glu Ser Phe Glu Phe Ser Lys Lys 
    50                  55                  60                  


Leu Gln Asp Ile Gly Cys Tyr Val Asp Val Asn Glu Leu Phe Thr Glu 
65                  70                  75                  80  


Ile Glu Thr Arg Arg Leu Asn Tyr Lys Ile Ser Phe Cys Asn Ile Asn 
                85                  90                  95      


Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly Gln Leu Tyr Leu Phe 
            100                 105                 110         


Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala His Gly Lys Pro Asn 
        115                 120                 125             


Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser Glu Asp Asn Leu Ala 
    130                 135                 140                 


Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln Ile Phe Tyr Arg Lys 
145                 150                 155                 160 


Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His Arg Ala Gly Glu Val 
                165                 170                 175     


Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys Arg Gln Phe Val Tyr 
            180                 185                 190         


Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Asp Lys Phe Met Leu His 
        195                 200                 205             


Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly Met Thr Ile Lys Glu 
    210                 215                 220                 


Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln Tyr Asp Glu Val Asn 
225                 230                 235                 240 


Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Thr Val 
                245                 250                 255     


Ile Asn Ser Lys Gly Glu Ile Leu Glu Gln Cys Ser Leu Asn Asp Ile 
            260                 265                 270         


Thr Thr Ala Ser Ala Asn Gly Thr Gln Met Thr Thr Pro Tyr His Lys 
        275                 280                 285             


Ile Leu Asp Lys Arg Glu Ile Glu Arg Leu Asn Ala Arg Val Gly Trp 
    290                 295                 300                 


Gly Glu Ile Glu Thr Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser His 
305                 310                 315                 320 


Val Val His Gln Ile Ser Gln Leu Met Leu Lys Tyr Asn Ala Ile Val 
                325                 330                 335     


Val Leu Glu Asp Leu Asn Phe Gly Phe Lys Arg Gly Arg Phe Lys Val 
            340                 345                 350         


Glu Lys Gln Ile Tyr Gln Asn Phe Glu Asn Ala Leu Ile Lys Lys Leu 
        355                 360                 365             


Asn His Leu Val Leu Lys Asp Lys Ala Asp Asp Glu Ile Gly Ser Tyr 
    370                 375                 380                 


Lys Asn Ala Leu Gln Leu Thr Asn Asn Phe Thr Asp Leu Lys Ser Ile 
385                 390                 395                 400 


Gly Lys Gln Thr Gly Phe Leu Phe Tyr Val Pro Ala Trp Asn Thr Ser 
                405                 410                 415     


Lys Ile Asp Pro Glu Thr Gly Phe Val Asp Leu Leu Lys Pro Arg Tyr 
            420                 425                 430         


Glu Asn Ile Ala Gln Ser Gln Ala Phe Phe Gly Lys Phe Asp Lys Ile 
        435                 440                 445             


Cys Tyr Asn Ala Asp Lys Asp Tyr Phe Glu Phe His Ile Asp Tyr Ala 
    450                 455                 460                 


Lys Phe Thr Asp Lys Ala Lys Asn Ser Arg Gln Ile Trp Thr Ile Cys 
465                 470                 475                 480 


Ser His Gly Asp Lys Arg Tyr Val Tyr Asp Lys Thr Ala Asn Gln Asn 
                485                 490                 495     


Lys Gly Ala Ala Lys Gly Ile Asn Val Asn Asp Glu Leu Lys Ser Leu 
            500                 505                 510         


Phe Ala Arg His His Ile Asn Glu Lys Gln Pro Asn Leu Val Met Asp 
        515                 520                 525             


Ile Cys Gln Asn Asn Asp Lys Glu Phe His Lys Ser Leu Met Tyr Leu 
    530                 535                 540                 


Leu Lys Thr Leu Leu Ala Leu Arg Tyr Ser Asn Ala Ser Ser Asp Glu 
545                 550                 555                 560 


Asp Phe Ile Leu Ser Pro Val Ala Asn Asp Glu Gly Val Phe Phe Asn 
                565                 570                 575     


Ser Ala Leu Ala Asp Asp Thr Gln Pro Gln Asn Ala Asp Ala Asn Gly 
            580                 585                 590         


Ala Tyr His Ile Ala Leu Lys Gly Leu Trp Leu Leu Asn Glu Leu Lys 
        595                 600                 605             


Asn Ser Asp Asp Leu Asn Lys Val Lys Leu Ala Ile Asp Asn Gln Thr 
    610                 615                 620                 


Trp Leu Asn Phe Ala Gln Asn Arg 
625                 630         


<210>  245
<211>  1230
<212>  PRT
<213>  Lachnospiraceae bacterium MD335

<400>  245

Met His Glu Asn Asn Gly Lys Ile Ala Asp Asn Phe Ile Gly Ile Tyr 
1               5                   10                  15      


Pro Val Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr 
            20                  25                  30          


Gln Glu Tyr Ile Glu Lys His Gly Ile Leu Asp Glu Asp Leu Lys Arg 
        35                  40                  45              


Ala Gly Asp Tyr Lys Ser Val Lys Lys Ile Ile Asp Ala Tyr His Lys 
    50                  55                  60                  


Tyr Phe Ile Asp Glu Ala Leu Asn Gly Ile Gln Leu Asp Gly Leu Lys 
65                  70                  75                  80  


Asn Tyr Tyr Glu Leu Tyr Glu Lys Lys Arg Asp Asn Asn Glu Glu Lys 
                85                  90                  95      


Glu Phe Gln Lys Ile Gln Met Ser Leu Arg Lys Gln Ile Val Lys Arg 
            100                 105                 110         


Phe Ser Glu His Pro Gln Tyr Lys Tyr Leu Phe Lys Lys Glu Leu Ile 
        115                 120                 125             


Lys Asn Val Leu Pro Glu Phe Thr Lys Asp Asn Ala Glu Glu Gln Thr 
    130                 135                 140                 


Leu Val Lys Ser Phe Gln Glu Phe Thr Thr Tyr Phe Glu Gly Phe His 
145                 150                 155                 160 


Gln Asn Arg Lys Asn Met Tyr Ser Asp Glu Glu Lys Ser Thr Ala Ile 
                165                 170                 175     


Ala Tyr Arg Val Val His Gln Asn Leu Pro Lys Tyr Ile Asp Asn Met 
            180                 185                 190         


Arg Ile Phe Ser Met Ile Leu Asn Thr Asp Ile Arg Ser Asp Leu Thr 
        195                 200                 205             


Glu Leu Phe Asn Asn Leu Lys Thr Lys Met Asp Ile Thr Ile Val Glu 
    210                 215                 220                 


Glu Tyr Phe Ala Ile Asp Gly Phe Asn Lys Val Val Asn Gln Lys Gly 
225                 230                 235                 240 


Ile Asp Val Tyr Asn Thr Ile Leu Gly Ala Phe Ser Thr Asp Asp Asn 
                245                 250                 255     


Thr Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            260                 265                 270         


Asn Lys Ala Lys Leu Pro Lys Leu Lys Pro Leu Phe Lys Gln Ile Leu 
        275                 280                 285             


Ser Asp Arg Asp Lys Ile Ser Phe Ile Pro Glu Gln Phe Asp Ser Asp 
    290                 295                 300                 


Thr Glu Val Leu Glu Ala Val Asp Met Phe Tyr Asn Arg Leu Leu Gln 
305                 310                 315                 320 


Phe Val Ile Glu Asn Glu Gly Gln Ile Thr Ile Ser Lys Leu Leu Thr 
                325                 330                 335     


Asn Phe Ser Ala Tyr Asp Leu Asn Lys Ile Tyr Val Lys Asn Asp Thr 
            340                 345                 350         


Thr Ile Ser Ala Ile Ser Asn Asp Leu Phe Asp Asp Trp Ser Tyr Ile 
        355                 360                 365             


Ser Lys Ala Val Arg Glu Asn Tyr Asp Ser Glu Asn Val Asp Lys Asn 
    370                 375                 380                 


Lys Arg Ala Ala Ala Tyr Glu Glu Lys Lys Glu Lys Ala Leu Ser Lys 
385                 390                 395                 400 


Ile Lys Met Tyr Ser Ile Glu Glu Leu Asn Phe Phe Val Lys Lys Tyr 
                405                 410                 415     


Ser Cys Asn Glu Cys His Ile Glu Gly Tyr Phe Glu Arg Arg Ile Leu 
            420                 425                 430         


Glu Ile Leu Asp Lys Met Arg Tyr Ala Tyr Glu Ser Cys Lys Ile Leu 
        435                 440                 445             


His Asp Lys Gly Leu Ile Asn Asn Ile Ser Leu Cys Gln Asp Arg Gln 
    450                 455                 460                 


Ala Ile Ser Glu Leu Lys Asp Phe Leu Asp Ser Ile Lys Glu Val Gln 
465                 470                 475                 480 


Trp Leu Leu Lys Pro Leu Met Ile Gly Gln Glu Gln Ala Asp Lys Glu 
                485                 490                 495     


Glu Ala Phe Tyr Thr Glu Leu Leu Arg Ile Trp Glu Glu Leu Glu Pro 
            500                 505                 510         


Ile Thr Leu Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr Lys Lys Pro 
        515                 520                 525             


Tyr Thr Leu Glu Lys Val Lys Leu Asn Phe Tyr Lys Ser Thr Leu Leu 
    530                 535                 540                 


Asp Gly Trp Asp Lys Asn Lys Glu Lys Asp Asn Leu Gly Ile Ile Leu 
545                 550                 555                 560 


Leu Lys Asp Gly Gln Tyr Tyr Leu Gly Ile Met Asn Arg Arg Asn Asn 
                565                 570                 575     


Lys Ile Ala Asp Asp Ala Pro Leu Ala Lys Thr Asp Asn Val Tyr Arg 
            580                 585                 590         


Lys Met Glu Tyr Lys Leu Leu Thr Lys Val Ser Ala Asn Leu Pro Arg 
        595                 600                 605             


Ile Phe Leu Lys Asp Lys Tyr Asn Pro Ser Glu Glu Met Leu Glu Lys 
    610                 615                 620                 


Tyr Glu Lys Gly Thr His Leu Lys Gly Glu Asn Phe Cys Ile Asp Asp 
625                 630                 635                 640 


Cys Arg Glu Leu Ile Asp Phe Phe Lys Lys Gly Ile Lys Gln Tyr Glu 
                645                 650                 655     


Asp Trp Gly Gln Phe Asp Phe Lys Phe Ser Asp Thr Glu Ser Tyr Asp 
            660                 665                 670         


Asp Ile Ser Ala Phe Tyr Lys Glu Val Glu His Gln Gly Tyr Lys Ile 
        675                 680                 685             


Thr Phe Arg Asp Ile Asp Glu Thr Tyr Ile Asp Ser Leu Val Asn Glu 
    690                 695                 700                 


Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Tyr 
705                 710                 715                 720 


Ser Lys Gly Thr Lys Asn Leu His Thr Leu Tyr Trp Glu Met Leu Phe 
                725                 730                 735     


Ser Gln Gln Asn Leu Gln Asn Ile Val Tyr Lys Leu Asn Gly Asn Ala 
            740                 745                 750         


Glu Ile Phe Tyr Arg Lys Ala Ser Ile Asn Gln Lys Asp Val Val Val 
        755                 760                 765             


His Lys Ala Asp Leu Pro Ile Lys Asn Lys Asp Pro Gln Asn Ser Lys 
    770                 775                 780                 


Lys Glu Ser Met Phe Asp Tyr Asp Ile Ile Lys Asp Lys Arg Phe Thr 
785                 790                 795                 800 


Cys Asp Lys Tyr Gln Phe His Val Pro Ile Thr Met Asn Phe Lys Ala 
                805                 810                 815     


Leu Gly Glu Asn His Phe Asn Arg Lys Val Asn Arg Leu Ile His Asp 
            820                 825                 830         


Ala Glu Asn Met His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
        835                 840                 845             


Ile Tyr Leu Cys Met Ile Asp Met Lys Gly Asn Ile Val Lys Gln Ile 
    850                 855                 860                 


Ser Leu Asn Glu Ile Ile Ser Tyr Asp Lys Asn Lys Leu Glu His Lys 
865                 870                 875                 880 


Arg Asn Tyr His Gln Leu Leu Lys Thr Arg Glu Asp Glu Asn Lys Ser 
                885                 890                 895     


Ala Arg Gln Ser Trp Gln Thr Ile His Thr Ile Lys Glu Leu Lys Glu 
            900                 905                 910         


Gly Tyr Leu Ser Gln Val Ile His Val Ile Thr Asp Leu Met Val Glu 
        915                 920                 925             


Tyr Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys Gln 
    930                 935                 940                 


Gly Arg Gln Lys Phe Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met 
945                 950                 955                 960 


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Ser Lys Gly Met Asp 
                965                 970                 975     


Glu Asp Gly Gly Leu Leu His Ala Tyr Gln Leu Thr Asp Glu Phe Lys 
            980                 985                 990         


Ser Phe Lys Gln Leu Gly Lys Gln  Ser Gly Phe Leu Tyr  Tyr Ile Pro 
        995                 1000                 1005             


Ala Trp  Asn Thr Ser Lys Leu  Asp Pro Thr Thr Gly  Phe Val Asn 
    1010                 1015                 1020             


Leu Phe  Tyr Thr Lys Tyr Glu  Ser Val Glu Lys Ser  Lys Glu Phe 
    1025                 1030                 1035             


Ile Asn  Asn Phe Thr Ser Ile  Leu Tyr Asn Gln Glu  Arg Glu Tyr 
    1040                 1045                 1050             


Phe Glu  Phe Leu Phe Asp Tyr  Ser Ala Phe Thr Ser  Lys Ala Glu 
    1055                 1060                 1065             


Gly Ser  Arg Leu Lys Trp Thr  Val Cys Ser Lys Gly  Glu Arg Val 
    1070                 1075                 1080             


Glu Thr  Tyr Arg Asn Pro Lys  Lys Asn Asn Glu Trp  Asp Thr Gln 
    1085                 1090                 1095             


Lys Ile  Asp Leu Thr Phe Glu  Leu Lys Lys Leu Phe  Asn Asp Tyr 
    1100                 1105                 1110             


Ser Ile  Ser Leu Leu Asp Gly  Asp Leu Arg Glu Gln  Met Gly Lys 
    1115                 1120                 1125             


Ile Asp  Lys Ala Asp Phe Tyr  Lys Lys Phe Met Lys  Leu Phe Ala 
    1130                 1135                 1140             


Leu Ile  Val Gln Met Arg Asn  Ser Asp Glu Arg Glu  Asp Lys Leu 
    1145                 1150                 1155             


Ile Ser  Pro Val Leu Asn Lys  Tyr Gly Ala Phe Phe  Glu Thr Gly 
    1160                 1165                 1170             


Lys Asn  Glu Arg Met Pro Leu  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1175                 1180                 1185             


Asn Ile  Ala Arg Lys Gly Leu  Trp Ile Ile Glu Lys  Ile Lys Asn 
    1190                 1195                 1200             


Thr Asp  Val Glu Gln Leu Asp  Lys Val Lys Leu Thr  Ile Ser Asn 
    1205                 1210                 1215             


Lys Glu  Trp Leu Gln Tyr Ala  Gln Glu His Ile Leu  
    1220                 1225                 1230 


<210>  246
<211>  1253
<212>  PRT
<213>  Prevotella albensis

<400>  246

Met Asn Ile Lys Asn Phe Thr Gly Leu Tyr Pro Leu Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Lys Glu Asn Ile Glu Lys 
            20                  25                  30          


Asn Gly Ile Leu Thr Lys Asp Glu Gln Arg Ala Lys Asp Tyr Leu Ile 
        35                  40                  45              


Val Lys Gly Phe Ile Asp Glu Tyr His Lys Gln Phe Ile Lys Asp Arg 
    50                  55                  60                  


Leu Trp Asp Phe Lys Leu Pro Leu Glu Ser Glu Gly Glu Lys Asn Ser 
65                  70                  75                  80  


Leu Glu Glu Tyr Gln Glu Leu Tyr Glu Leu Thr Lys Arg Asn Asp Ala 
                85                  90                  95      


Gln Glu Ala Asp Phe Thr Glu Ile Lys Asp Asn Leu Arg Ser Ser Ile 
            100                 105                 110         


Thr Glu Gln Leu Thr Lys Ser Gly Ser Ala Tyr Asp Arg Ile Phe Lys 
        115                 120                 125             


Lys Glu Phe Ile Arg Glu Asp Leu Val Asn Phe Leu Glu Asp Glu Lys 
    130                 135                 140                 


Asp Lys Asn Ile Val Lys Gln Phe Glu Asp Phe Thr Thr Tyr Phe Thr 
145                 150                 155                 160 


Gly Phe Tyr Glu Asn Arg Lys Asn Met Tyr Ser Ser Glu Glu Lys Ser 
                165                 170                 175     


Thr Ala Ile Ala Tyr Arg Leu Ile His Gln Asn Leu Pro Lys Phe Met 
            180                 185                 190         


Asp Asn Met Arg Ser Phe Ala Lys Ile Ala Asn Ser Ser Val Ser Glu 
        195                 200                 205             


His Phe Ser Asp Ile Tyr Glu Ser Trp Lys Glu Tyr Leu Asn Val Asn 
    210                 215                 220                 


Ser Ile Glu Glu Ile Phe Gln Leu Asp Tyr Phe Ser Glu Thr Leu Thr 
225                 230                 235                 240 


Gln Pro His Ile Glu Val Tyr Asn Tyr Ile Ile Gly Lys Lys Val Leu 
                245                 250                 255     


Glu Asp Gly Thr Glu Ile Lys Gly Ile Asn Glu Tyr Val Asn Leu Tyr 
            260                 265                 270         


Asn Gln Gln Gln Lys Asp Lys Ser Lys Arg Leu Pro Phe Leu Val Pro 
        275                 280                 285             


Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Lys Leu Ser Trp Ile Ala 
    290                 295                 300                 


Glu Glu Phe Asp Ser Asp Lys Lys Met Leu Ser Ala Ile Thr Glu Ser 
305                 310                 315                 320 


Tyr Asn His Leu His Asn Val Leu Met Gly Asn Glu Asn Glu Ser Leu 
                325                 330                 335     


Arg Asn Leu Leu Leu Asn Ile Lys Asp Tyr Asn Leu Glu Lys Ile Asn 
            340                 345                 350         


Ile Thr Asn Asp Leu Ser Leu Thr Glu Ile Ser Gln Asn Leu Phe Gly 
        355                 360                 365             


Arg Tyr Asp Val Phe Thr Asn Gly Ile Lys Asn Lys Leu Arg Val Leu 
    370                 375                 380                 


Thr Pro Arg Lys Lys Lys Glu Thr Asp Glu Asn Phe Glu Asp Arg Ile 
385                 390                 395                 400 


Asn Lys Ile Phe Lys Thr Gln Lys Ser Phe Ser Ile Ala Phe Leu Asn 
                405                 410                 415     


Lys Leu Pro Gln Pro Glu Met Glu Asp Gly Lys Pro Arg Asn Ile Glu 
            420                 425                 430         


Asp Tyr Phe Ile Thr Gln Gly Ala Ile Asn Thr Lys Ser Ile Gln Lys 
        435                 440                 445             


Glu Asp Ile Phe Ala Gln Ile Glu Asn Ala Tyr Glu Asp Ala Gln Val 
    450                 455                 460                 


Phe Leu Gln Ile Lys Asp Thr Asp Asn Lys Leu Ser Gln Asn Lys Thr 
465                 470                 475                 480 


Ala Val Glu Lys Ile Lys Thr Leu Leu Asp Ala Leu Lys Glu Leu Gln 
                485                 490                 495     


His Phe Ile Lys Pro Leu Leu Gly Ser Gly Glu Glu Asn Glu Lys Asp 
            500                 505                 510         


Glu Leu Phe Tyr Gly Ser Phe Leu Ala Ile Trp Asp Glu Leu Asp Thr 
        515                 520                 525             


Ile Thr Pro Leu Tyr Asn Lys Val Arg Asn Trp Leu Thr Arg Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Asp Asn Ala Gln Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Val Asn Lys Glu His Asp Cys Ala Gly Ile Leu Leu 
                565                 570                 575     


Arg Lys Asn Asp Ser Tyr Tyr Leu Gly Ile Ile Asn Lys Lys Thr Asn 
            580                 585                 590         


His Ile Phe Asp Thr Asp Ile Thr Pro Ser Asp Gly Glu Cys Tyr Asp 
        595                 600                 605             


Lys Ile Asp Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys 
    610                 615                 620                 


Val Phe Phe Ser Lys Ser Arg Ile Lys Glu Phe Glu Pro Ser Glu Ala 
625                 630                 635                 640 


Ile Ile Asn Cys Tyr Lys Lys Gly Thr His Lys Lys Gly Lys Asn Phe 
                645                 650                 655     


Asn Leu Thr Asp Cys His Arg Leu Ile Asn Phe Phe Lys Thr Ser Ile 
            660                 665                 670         


Glu Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Ser Asp Thr 
        675                 680                 685             


Glu Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val Glu Gln Gln 
    690                 695                 700                 


Gly Tyr Arg Leu Thr Ser His Pro Val Ser Ala Ser Tyr Ile His Ser 
705                 710                 715                 720 


Leu Val Lys Glu Gly Lys Leu Tyr Leu Phe Gln Ile Trp Asn Lys Asp 
                725                 730                 735     


Phe Ser Gln Phe Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr Trp 
            740                 745                 750         


Lys Met Leu Phe Asp Lys Arg Asn Leu Ser Asp Val Val Tyr Lys Leu 
        755                 760                 765             


Asn Gly Gln Ala Glu Val Phe Tyr Arg Lys Ser Ser Ile Glu His Gln 
    770                 775                 780                 


Asn Arg Ile Ile His Pro Ala Gln His Pro Ile Thr Asn Lys Asn Glu 
785                 790                 795                 800 


Leu Asn Lys Lys His Thr Ser Thr Phe Lys Tyr Asp Ile Ile Lys Asp 
                805                 810                 815     


Arg Arg Tyr Thr Val Asp Lys Phe Gln Phe His Val Pro Ile Thr Ile 
            820                 825                 830         


Asn Phe Lys Ala Thr Gly Gln Asn Asn Ile Asn Pro Ile Val Gln Glu 
        835                 840                 845             


Val Ile Arg Gln Asn Gly Ile Thr His Ile Ile Gly Ile Asp Arg Gly 
    850                 855                 860                 


Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Leu Lys Gly Asn Ile 
865                 870                 875                 880 


Ile Lys Gln Met Thr Leu Asn Glu Ile Ile Asn Glu Tyr Lys Gly Val 
                885                 890                 895     


Thr Tyr Lys Thr Asn Tyr His Asn Leu Leu Glu Lys Arg Glu Lys Glu 
            900                 905                 910         


Arg Thr Glu Ala Arg His Ser Trp Ser Ser Ile Glu Ser Ile Lys Glu 
        915                 920                 925             


Leu Lys Asp Gly Tyr Met Ser Gln Val Ile His Lys Ile Thr Asp Met 
    930                 935                 940                 


Met Val Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu Asn Gly Gly 
945                 950                 955                 960 


Phe Met Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
                965                 970                 975     


Glu Lys Lys Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Lys Leu 
            980                 985                 990         


Asp Ala Asn Glu Val Gly Gly Val  Leu Asn Ala Tyr Gln  Leu Thr Asn 
        995                 1000                 1005             


Lys Phe  Glu Ser Phe Lys Lys  Ile Gly Lys Gln Ser  Gly Phe Leu 
    1010                 1015                 1020             


Phe Tyr  Ile Pro Ala Trp Asn  Thr Ser Lys Ile Asp  Pro Ile Thr 
    1025                 1030                 1035             


Gly Phe  Val Asn Leu Phe Asn  Thr Arg Tyr Glu Ser  Ile Lys Glu 
    1040                 1045                 1050             


Thr Lys  Val Phe Trp Ser Lys  Phe Asp Ile Ile Arg  Tyr Asn Lys 
    1055                 1060                 1065             


Glu Lys  Asn Trp Phe Glu Phe  Val Phe Asp Tyr Asn  Thr Phe Thr 
    1070                 1075                 1080             


Thr Lys  Ala Glu Gly Thr Arg  Thr Lys Trp Thr Leu  Cys Thr His 
    1085                 1090                 1095             


Gly Thr  Arg Ile Gln Thr Phe  Arg Asn Pro Glu Lys  Asn Ala Gln 
    1100                 1105                 1110             


Trp Asp  Asn Lys Glu Ile Asn  Leu Thr Glu Ser Phe  Lys Ala Leu 
    1115                 1120                 1125             


Phe Glu  Lys Tyr Lys Ile Asp  Ile Thr Ser Asn Leu  Lys Glu Ser 
    1130                 1135                 1140             


Ile Met  Gln Glu Thr Glu Lys  Lys Phe Phe Gln Glu  Leu His Asn 
    1145                 1150                 1155             


Leu Leu  His Leu Thr Leu Gln  Met Arg Asn Ser Val  Thr Gly Thr 
    1160                 1165                 1170             


Asp Ile  Asp Tyr Leu Ile Ser  Pro Val Ala Asp Glu  Asp Gly Asn 
    1175                 1180                 1185             


Phe Tyr  Asp Ser Arg Ile Asn  Gly Lys Asn Phe Pro  Glu Asn Ala 
    1190                 1195                 1200             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Gly  Leu Met Leu 
    1205                 1210                 1215             


Ile Arg  Gln Ile Lys Gln Ala  Asp Pro Gln Lys Lys  Phe Lys Phe 
    1220                 1225                 1230             


Glu Thr  Ile Thr Asn Lys Asp  Trp Leu Lys Phe Ala  Gln Asp Lys 
    1235                 1240                 1245             


Pro Tyr  Leu Lys Asp 
    1250             


<210>  247
<211>  1250
<212>  PRT
<213>  Smithella sp. SC K08D17

<400>  247

Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Lys Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Thr Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Met 
            340                 345                 350         


Tyr Phe Arg Ser Gly Ala Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Ser Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Ala Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Cys Pro Glu Asn Glu Lys Leu Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Asp Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Phe Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Ala Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Val Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Ile Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Ala Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Asn Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asp  Phe Lys Asn Phe Thr  Glu Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Ala Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Ser Ala Asp Phe  Phe Lys Ala Leu Met  Lys Asn Leu 
    1145                 1150                 1155             


Ser Ile  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Asp 
    1160                 1165                 1170             


Asn Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Lys Gly 
    1175                 1180                 1185             


Arg Phe  Phe Asp Ser Arg Lys  Ala Asp Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Val  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210>  248
<211>  1260
<212>  PRT
<213>  Porphyromonas crevioricanis

<400>  248

Met Asp Ser Leu Lys Asp Phe Thr Asn Leu Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu Asn Ile Glu 
            20                  25                  30          


Lys Ala Gly Ile Leu Lys Glu Asp Glu His Arg Ala Glu Ser Tyr Arg 
        35                  40                  45              


Arg Val Lys Lys Ile Ile Asp Thr Tyr His Lys Val Phe Ile Asp Ser 
    50                  55                  60                  


Ser Leu Glu Asn Met Ala Lys Met Gly Ile Glu Asn Glu Ile Lys Ala 
65                  70                  75                  80  


Met Leu Gln Ser Phe Cys Glu Leu Tyr Lys Lys Asp His Arg Thr Glu 
                85                  90                  95      


Gly Glu Asp Lys Ala Leu Asp Lys Ile Arg Ala Val Leu Arg Gly Leu 
            100                 105                 110         


Ile Val Gly Ala Phe Thr Gly Val Cys Gly Arg Arg Glu Asn Thr Val 
        115                 120                 125             


Gln Asn Glu Lys Tyr Glu Ser Leu Phe Lys Glu Lys Leu Ile Lys Glu 
    130                 135                 140                 


Ile Leu Pro Asp Phe Val Leu Ser Thr Glu Ala Glu Ser Leu Pro Phe 
145                 150                 155                 160 


Ser Val Glu Glu Ala Thr Arg Ser Leu Lys Glu Phe Asp Ser Phe Thr 
                165                 170                 175     


Ser Tyr Phe Ala Gly Phe Tyr Glu Asn Arg Lys Asn Ile Tyr Ser Thr 
            180                 185                 190         


Lys Pro Gln Ser Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu 
        195                 200                 205             


Pro Lys Phe Ile Asp Asn Ile Leu Val Phe Gln Lys Ile Lys Glu Pro 
    210                 215                 220                 


Ile Ala Lys Glu Leu Glu His Ile Arg Ala Asp Phe Ser Ala Gly Gly 
225                 230                 235                 240 


Tyr Ile Lys Lys Asp Glu Arg Leu Glu Asp Ile Phe Ser Leu Asn Tyr 
                245                 250                 255     


Tyr Ile His Val Leu Ser Gln Ala Gly Ile Glu Lys Tyr Asn Ala Leu 
            260                 265                 270         


Ile Gly Lys Ile Val Thr Glu Gly Asp Gly Glu Met Lys Gly Leu Asn 
        275                 280                 285             


Glu His Ile Asn Leu Tyr Asn Gln Gln Arg Gly Arg Glu Asp Arg Leu 
    290                 295                 300                 


Pro Leu Phe Arg Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Gln 
305                 310                 315                 320 


Leu Ser Tyr Leu Pro Glu Ser Phe Glu Lys Asp Glu Glu Leu Leu Arg 
                325                 330                 335     


Ala Leu Lys Glu Phe Tyr Asp His Ile Ala Glu Asp Ile Leu Gly Arg 
            340                 345                 350         


Thr Gln Gln Leu Met Thr Ser Ile Ser Glu Tyr Asp Leu Ser Arg Ile 
        355                 360                 365             


Tyr Val Arg Asn Asp Ser Gln Leu Thr Asp Ile Ser Lys Lys Met Leu 
    370                 375                 380                 


Gly Asp Trp Asn Ala Ile Tyr Met Ala Arg Glu Arg Ala Tyr Asp His 
385                 390                 395                 400 


Glu Gln Ala Pro Lys Arg Ile Thr Ala Lys Tyr Glu Arg Asp Arg Ile 
                405                 410                 415     


Lys Ala Leu Lys Gly Glu Glu Ser Ile Ser Leu Ala Asn Leu Asn Ser 
            420                 425                 430         


Cys Ile Ala Phe Leu Asp Asn Val Arg Asp Cys Arg Val Asp Thr Tyr 
        435                 440                 445             


Leu Ser Thr Leu Gly Gln Lys Glu Gly Pro His Gly Leu Ser Asn Leu 
    450                 455                 460                 


Val Glu Asn Val Phe Ala Ser Tyr His Glu Ala Glu Gln Leu Leu Ser 
465                 470                 475                 480 


Phe Pro Tyr Pro Glu Glu Asn Asn Leu Ile Gln Asp Lys Asp Asn Val 
                485                 490                 495     


Val Leu Ile Lys Asn Leu Leu Asp Asn Ile Ser Asp Leu Gln Arg Phe 
            500                 505                 510         


Leu Lys Pro Leu Trp Gly Met Gly Asp Glu Pro Asp Lys Asp Glu Arg 
        515                 520                 525             


Phe Tyr Gly Glu Tyr Asn Tyr Ile Arg Gly Ala Leu Asp Gln Val Ile 
    530                 535                 540                 


Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Arg Lys Pro Tyr Ser 
545                 550                 555                 560 


Thr Arg Lys Val Lys Leu Asn Phe Gly Asn Ser Gln Leu Leu Ser Gly 
                565                 570                 575     


Trp Asp Arg Asn Lys Glu Lys Asp Asn Ser Cys Val Ile Leu Arg Lys 
            580                 585                 590         


Gly Gln Asn Phe Tyr Leu Ala Ile Met Asn Asn Arg His Lys Arg Ser 
        595                 600                 605             


Phe Glu Asn Lys Val Leu Pro Glu Tyr Lys Glu Gly Glu Pro Tyr Phe 
    610                 615                 620                 


Glu Lys Met Asp Tyr Lys Phe Leu Pro Asp Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Leu Ser Lys Lys Gly Ile Glu Ile Tyr Lys Pro Ser Pro 
                645                 650                 655     


Lys Leu Leu Glu Gln Tyr Gly His Gly Thr His Lys Lys Gly Asp Thr 
            660                 665                 670         


Phe Ser Met Asp Asp Leu His Glu Leu Ile Asp Phe Phe Lys His Ser 
        675                 680                 685             


Ile Glu Ala His Glu Asp Trp Lys Gln Phe Gly Phe Lys Phe Ser Asp 
    690                 695                 700                 


Thr Ala Thr Tyr Glu Asn Val Ser Ser Phe Tyr Arg Glu Val Glu Asp 
705                 710                 715                 720 


Gln Gly Tyr Lys Leu Ser Phe Arg Lys Val Ser Glu Ser Tyr Val Tyr 
                725                 730                 735     


Ser Leu Ile Asp Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Cys Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Trp Arg Met Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Ile Tyr Lys 
    770                 775                 780                 


Leu Asp Gly Lys Ala Glu Ile Phe Phe Arg Glu Lys Ser Leu Lys Asn 
785                 790                 795                 800 


Asp His Pro Thr His Pro Ala Gly Lys Pro Ile Lys Lys Lys Ser Arg 
                805                 810                 815     


Gln Lys Lys Gly Glu Glu Ser Leu Phe Glu Tyr Asp Leu Val Lys Asp 
            820                 825                 830         


Arg Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Lys Cys Ser Ala Gly Ser Lys Val Asn Asp Met Val Asn Ala 
    850                 855                 860                 


His Ile Arg Glu Ala Lys Asp Met His Val Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg Asn Leu Leu Tyr Ile Cys Val Ile Asp Ser Arg Gly Thr Ile 
                885                 890                 895     


Leu Asp Gln Ile Ser Leu Asn Thr Ile Asn Asp Ile Asp Tyr His Asp 
            900                 905                 910         


Leu Leu Glu Ser Arg Asp Lys Asp Arg Gln Gln Glu Arg Arg Asn Trp 
        915                 920                 925             


Gln Thr Ile Glu Gly Ile Lys Glu Leu Lys Gln Gly Tyr Leu Ser Gln 
    930                 935                 940                 


Ala Val His Arg Ile Ala Glu Leu Met Val Ala Tyr Lys Ala Val Val 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Met Gly Phe Lys Arg Gly Arg Gln Lys Val 
                965                 970                 975     


Glu Ser Ser Val Tyr Gln Gln Phe Glu Lys Gln Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Leu Val Asp Lys Lys Lys  Arg Pro Glu Asp Ile  Gly Gly Leu 
        995                 1000                 1005             


Leu Arg  Ala Tyr Gln Phe Thr  Ala Pro Phe Lys Ser  Phe Lys Glu 
    1010                 1015                 1020             


Met Gly  Lys Gln Asn Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1025                 1030                 1035             


Thr Ser  Asn Ile Asp Pro Thr  Thr Gly Phe Val Asn  Leu Phe His 
    1040                 1045                 1050             


Ala Gln  Tyr Glu Asn Val Asp  Lys Ala Lys Ser Phe  Phe Gln Lys 
    1055                 1060                 1065             


Phe Asp  Ser Ile Ser Tyr Asn  Pro Lys Lys Asp Trp  Phe Glu Phe 
    1070                 1075                 1080             


Ala Phe  Asp Tyr Lys Asn Phe  Thr Lys Lys Ala Glu  Gly Ser Arg 
    1085                 1090                 1095             


Ser Met  Trp Ile Leu Cys Thr  His Gly Ser Arg Ile  Lys Asn Phe 
    1100                 1105                 1110             


Arg Asn  Ser Gln Lys Asn Gly  Gln Trp Asp Ser Glu  Glu Phe Ala 
    1115                 1120                 1125             


Leu Thr  Glu Ala Phe Lys Ser  Leu Phe Val Arg Tyr  Glu Ile Asp 
    1130                 1135                 1140             


Tyr Thr  Ala Asp Leu Lys Thr  Ala Ile Val Asp Glu  Lys Gln Lys 
    1145                 1150                 1155             


Asp Phe  Phe Val Asp Leu Leu  Lys Leu Phe Lys Leu  Thr Val Gln 
    1160                 1165                 1170             


Met Arg  Asn Ser Trp Lys Glu  Lys Asp Leu Asp Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Pro Val  Ala Gly Ala Asp Gly  Arg Phe Phe Asp Thr  Arg Glu Gly 
    1190                 1195                 1200             


Asn Lys  Ser Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1205                 1210                 1215             


Ile Ala  Leu Lys Gly Leu Trp  Ala Leu Arg Gln Ile  Arg Gln Thr 
    1220                 1225                 1230             


Ser Glu  Gly Gly Lys Leu Lys  Leu Ala Ile Ser Asn  Lys Glu Trp 
    1235                 1240                 1245             


Leu Gln  Phe Val Gln Glu Arg  Ser Tyr Glu Lys Asp  
    1250                 1255                 1260 


<210>  249
<211>  43
<212>  DNA
<213>  Unknown

<220>
<223>  gRNA

<400>  249
aaatttctac tgtagtagat gtggcagctc aaaaattggc tac                         43


