                         SEQUENCE LISTING

<110>  The Trustees Of The University Of Pennsylvania
       Zhao, Yangbing
 
<120>  COMPOSITIONS AND METHODS COMPRISING PROSTATE STEM CELL ANTIGEN 
       (PSCA) CHIMERIC ANTIGEN RECEPTORS (CARS)

<130>  046483-7280WO1(02352)

<150>  62/985,808
<151>  2020-03-05

<150>  62/898,896
<151>  2019-09-11

<160>  148   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 HCDR1

<400>  1

Asp Tyr Tyr Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 HCDR2

<400>  2

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 HCDR3

<400>  3

Thr Gly Gly Phe 
1               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 LCDR1

<400>  4

Ser Ala Ser Ser Ser Val Arg Phe Ile His Trp 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 LCDR2

<400>  5

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 LCDR3

<400>  6

Gln Gln Trp Ser Ser Ser Pro Phe Thr 
1               5                   


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 VH

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 VL

<400>  8

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  9
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 scFv

<400>  9

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp 
                165                 170                 175     


Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly 
    210                 215                 220                 


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235     


<210>  10
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge

<400>  10

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  11

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  12
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  12

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS transmembrane domain

<400>  13

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  14
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 ICD

<400>  14

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40      


<210>  15
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 ICD

<400>  15

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  16
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS ICD

<400>  16

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  17
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS YMNM ICD

<400>  17

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Asn Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta ICD

<400>  18

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta Q14K ICD

<400>  19

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  20
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.BBZ

<400>  20
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      960

ctgtcactgg ttatcaccct ttactgcaaa cggggcagaa agaaactcct gtatatattc     1020

aaacaaccat ttatgagacc agtacaaact actcaagagg aagatggctg tagctgccga     1080

tttccagaag aagaagaagg aggatgtgaa ctgagagtga agttcagcag gagcgcagac     1140

gcccccgcgt acaagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1200

gaggagtacg acgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1260

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1320

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1380

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1440

ccccctcgct aa                                                         1452


<210>  21
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.BBZ

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
305                 310                 315                 320 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  22
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.28Z

<400>  22
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      960

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg     1020

cacagtgact acatgaacat gactccccgc cgccccgggc ccacccgcaa gcattaccag     1080

ccctatgccc caccacgcga cttcgcagcc tatcgctcca gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgcaga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  23
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.28Z

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  24
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.ICOSZ

<400>  24
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatttctg gttacccata ggatgtgcag cctttgttgt agtctgcatt      960

ttgggatgca tacttatttg ttggcttaca aaaaagaagt attcatccag tgtgcacgac     1020

cctaacggtg aatacatgtt catgagagca gtgaacacag ccaaaaaatc cagactcaca     1080

gatgtgaccc taagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1140

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1200

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     1260

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1320

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1380

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1434


<210>  25
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.ICOSZ

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile 
305                 310                 315                 320 


Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser 
                325                 330                 335     


Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn 
            340                 345                 350         


Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe 
        355                 360                 365             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
385                 390                 395                 400 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  26
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.ICOS.YMNM.Z

<400>  26
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg      840

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      900

gacttcgcct gtgatttctg gttacccata ggatgtgcag cctttgttgt agtctgcatt      960

ttgggatgca tacttatttg ttggcttaca aaaaagaagt attcatccag tgtgcacgac     1020

cctaacggtg aatacatgaa catgagagca gtgaacacag ccaaaaaatc cagactcaca     1080

gatgtgaccc taagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1140

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1200

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     1260

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1320

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1380

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1434


<210>  27
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSCA CAR 2B3.ICOS.YMNM.Z

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            260                 265                 270         


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        275                 280                 285             


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    290                 295                 300                 


Asp Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile 
305                 310                 315                 320 


Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser 
                325                 330                 335     


Ser Val His Asp Pro Asn Gly Glu Tyr Met Asn Met Arg Ala Val Asn 
            340                 345                 350         


Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe 
        355                 360                 365             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
385                 390                 395                 400 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 HCDR1

<400>  28

Ser Asn Trp Ile Gly 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 HCDR2

<400>  29

Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 HCDR3

<400>  30

Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu 
1               5                   10  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 LCDR1

<400>  31

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 LCDR2

<400>  32

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 LCDR3

<400>  33

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  34
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 VH

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 VL

<400>  35

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys 
            100                 105                 


<210>  36
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 scFv

<400>  36

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Ile Lys 
            


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  37

Gly Gly Gly Gly Ser 
1               5   


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  39
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B3L2F5.BBZ CAR

<400>  39
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

ggaggtggtg gatccggcgg agggggaagt ggcgggggtg ggtccggcgg cggcggctcg      840

gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc      900

tcctgtaagg gttctggata cagttttacc agcaactgga tcggctgggt gcgccagatg      960

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac     1020

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac     1080

ctgcagtgga acagcctgaa ggcctcggac accgccatgt attactgtgc gagacaaact     1140

ggtttcctct ggtccttcga tctctggggc cgtggcaccc tggtcactgt ctcctcaggt     1200

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgccatcca gttgacccag     1260

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt     1320

caggacatta gcagtgcttt agcctggtat cagcagaaac cggggaaagc tcctaagctc     1380

ctgatctatg atgcctccag tttggaaagt ggggtcccat caaggttcag cggcagtgga     1440

tctgggacag atttcactct caccatcagc agcctgcagc ctgaagattt tgcaacttat     1500

tactgtcaac agtttaatag ttacccgctc actttcggcg gagggaccaa ggtggagatc     1560

aaaatcaaaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg     1620

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg     1680

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg     1740

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1800

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1860

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1920

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1980

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     2040

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     2100

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     2160

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     2220

caggccctgc cccctcgcta a                                               2241


<210>  40
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3L2F5.BBZ CAR

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly 
        275                 280                 285             


Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly 
    290                 295                 300                 


Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser 
                325                 330                 335     


Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala 
            340                 345                 350         


Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala 
        355                 360                 365             


Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp 
    370                 375                 380                 


Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile 
                405                 410                 415     


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala 
        435                 440                 445             


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
    450                 455                 460                 


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
465                 470                 475                 480 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                485                 490                 495     


Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe 
            500                 505                 510         


Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala 
        515                 520                 525             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    530                 535                 540                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
545                 550                 555                 560 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                565                 570                 575     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            580                 585                 590         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        595                 600                 605             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    610                 615                 620                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
625                 630                 635                 640 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                645                 650                 655     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            660                 665                 670         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        675                 680                 685             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    690                 695                 700                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
705                 710                 715                 720 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                725                 730                 735     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745     


<210>  41
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B3S2F5.BBZ CAR

<400>  41
atggcgctac cggtgaccgc actcctgctg ccactcgccc tcctgctcca cgccgcccgc       60

cccgatatcc agctgaccca atcaccgtcg tccctgtctg cctccgtggg cgaccgggtg      120

acgatcacct gtagtgcctc gagcagtgta cggttcatcc actggtacca acagaagccc      180

ggcaaggcac caaagcggct gatctacgac accagcaagc tggcgtctgg ggtgcccagc      240

aggttctcgg gaagtggtag tggcacagac ttcactctca ccatcagttc actccagccg      300

gaggactttg ccacctacta ttgccagcag tggtcctcgt ccccctttac cttcggccag      360

ggaacaaagg tggaaattaa gggttcgacc tccggggggg gctccggtgg gggctccggc      420

ggggggggct catcggaggt tcagctggtg gagagcggcg gcggcctggt gcagcccggc      480

gggagtctgc ggctgtcctg tgccgccagc ggcttcaaca tcaaggacta ctacattcac      540

tgggtgcggc aagccccagg caagggtctg gagtgggtgg cttggattga ccctgaaaac      600

ggcgacactg agttcgtgcc aaaattccag gggcgggcga ccatctccgc cgacacctcc      660

aagaatacgg cctacctgca gatgaactcc ctgcgcgccg aagacacagc ggtctactac      720

tgcaagacag ggggtttctg gggccagggc accctcgtga ccgtttcgag tgccgccggc      780

ggaggtggtg gatccgaggt gcagctggtg cagtctggag cagaggtgaa aaagcccggg      840

gagtctctga agatctcctg taagggttct ggatacagtt ttaccagcaa ctggatcggc      900

tgggtgcgcc agatgcccgg gaaaggcctg gagtggatgg ggatcatcta tcctggtgac      960

tctgatacca gatacagccc gtccttccaa ggccaggtca ccatctcagc cgacaagtcc     1020

atcagcaccg cctacctgca gtggaacagc ctgaaggcct cggacaccgc catgtattac     1080

tgtgcgagac aaactggttt cctctggtcc ttcgatctct ggggccgtgg caccctggtc     1140

actgtctcct caggtggcgg tggctcgggc ggtggtgggt cgggtggcgg cggatctgcc     1200

atccagttga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc     1260

acttgccggg caagtcagga cattagcagt gctttagcct ggtatcagca gaaaccgggg     1320

aaagctccta agctcctgat ctatgatgcc tccagtttgg aaagtggggt cccatcaagg     1380

ttcagcggca gtggatctgg gacagatttc actctcacca tcagcagcct gcagcctgaa     1440

gattttgcaa cttattactg tcaacagttt aatagttacc cgctcacttt cggcggaggg     1500

accaaggtgg agatcaaaat caaaaccacg acgccagcgc cgcgaccacc aacaccggcg     1560

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg     1620

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg     1680

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1740

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1800

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1860

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1920

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1980

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     2040

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     2100

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     2160

gacgcccttc acatgcaggc cctgccccct cgctaa                               2196


<210>  42
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3S2F5.BBZ CAR

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser 
        35                  40                  45              


Ser Val Arg Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
            100                 105                 110         


Ser Ser Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
                165                 170                 175     


Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Val Ala Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys 
        195                 200                 205             


Phe Gln Gly Arg Ala Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Lys Thr Gly Gly Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser Ala Ala Gly Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser 
            260                 265                 270         


Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys 
        275                 280                 285             


Gly Ser Gly Tyr Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln 
    290                 295                 300                 


Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp 
305                 310                 315                 320 


Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser 
                325                 330                 335     


Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys 
            340                 345                 350         


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu 
        355                 360                 365             


Trp Ser Phe Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
385                 390                 395                 400 


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                405                 410                 415     


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu 
            420                 425                 430         


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        435                 440                 445             


Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    450                 455                 460                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
465                 470                 475                 480 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
                485                 490                 495     


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro 
            500                 505                 510         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        515                 520                 525             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    530                 535                 540                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
545                 550                 555                 560 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                565                 570                 575     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            580                 585                 590         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        595                 600                 605             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    610                 615                 620                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
625                 630                 635                 640 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                645                 650                 655     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            660                 665                 670         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        675                 680                 685             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    690                 695                 700                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
705                 710                 715                 720 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730     


<210>  43
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 VH

<400>  43
gaggttcagc tggtggagag cggcggcggc ctggtgcagc ccggcgggag tctgcggctg       60

tcctgtgccg ccagcggctt caacatcaag gactactaca ttcactgggt gcggcaagcc      120

ccaggcaagg gtctggagtg ggtggcttgg attgaccctg aaaacggcga cactgagttc      180

gtgccaaaat tccaggggcg ggcgaccatc tccgccgaca cctccaagaa tacggcctac      240

ctgcagatga actccctgcg cgccgaagac acagcggtct actactgcaa gacagggggt      300

ttctggggcc agggcaccct cgtgaccgtt tcgagt                                336


<210>  44
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 VL

<400>  44
gatatccagc tgacccaatc accgtcgtcc ctgtctgcct ccgtgggcga ccgggtgacg       60

atcacctgta gtgcctcgag cagtgtacgg ttcatccact ggtaccaaca gaagcccggc      120

aaggcaccaa agcggctgat ctacgacacc agcaagctgg cgtctggggt gcccagcagg      180

ttctcgggaa gtggtagtgg cacagacttc actctcacca tcagttcact ccagccggag      240

gactttgcca cctactattg ccagcagtgg tcctcgtccc cctttacctt cggccaggga      300

acaaaggtgg aaattaag                                                    318


<210>  45
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSCA 2B3 scFv

<400>  45
gatatccagc tgacccaatc accgtcgtcc ctgtctgcct ccgtgggcga ccgggtgacg       60

atcacctgta gtgcctcgag cagtgtacgg ttcatccact ggtaccaaca gaagcccggc      120

aaggcaccaa agcggctgat ctacgacacc agcaagctgg cgtctggggt gcccagcagg      180

ttctcgggaa gtggtagtgg cacagacttc actctcacca tcagttcact ccagccggag      240

gactttgcca cctactattg ccagcagtgg tcctcgtccc cctttacctt cggccaggga      300

acaaaggtgg aaattaaggg ttcgacctcc ggggggggct ccggtggggg ctccggcggg      360

gggggctcat cggaggttca gctggtggag agcggcggcg gcctggtgca gcccggcggg      420

agtctgcggc tgtcctgtgc cgccagcggc ttcaacatca aggactacta cattcactgg      480

gtgcggcaag ccccaggcaa gggtctggag tgggtggctt ggattgaccc tgaaaacggc      540

gacactgagt tcgtgccaaa attccagggg cgggcgacca tctccgccga cacctccaag      600

aatacggcct acctgcagat gaactccctg cgcgccgaag acacagcggt ctactactgc      660

aagacagggg gtttctgggg ccagggcacc ctcgtgaccg tttcgagt                   708


<210>  46
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 VH

<400>  46
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agcaactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga acagcctgaa ggcctcggac accgccatgt attactgtgc gagacaaact      300

ggtttcctct ggtccttcga tctctggggc cgtggcaccc tggtcactgt ctcctca         357


<210>  47
<211>  328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 VL

<400>  47
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc agtgctttag cctggtatca gcagaaaccg      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa aatcaaaa                                         328


<210>  48
<211>  730
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5 scFv

<400>  48
gaggtgcagc tggtgcagtc tggagcagag gtgaaaaagc ccggggagtc tctgaagatc       60

tcctgtaagg gttctggata cagttttacc agcaactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga acagcctgaa ggcctcggac accgccatgt attactgtgc gagacaaact      300

ggtttcctct ggtccttcga tctctggggc cgtggcaccc tggtcactgt ctcctcaggt      360

ggcggtggct cgggcggtgg tgggtcgggt ggcggcggat ctgccatcca gttgacccag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccgggcaagt      480

caggacatta gcagtgcttt agcctggtat cagcagaaac cggggaaagc tcctaagctc      540

ctgatctatg atgcctccag tttggaaagt ggggtcccat caaggttcag cggcagtgga      600

tctgggacag atttcactct caccatcagc agcctgcagc ctgaagattt tgcaacttat      660

tactgtcaac agtttaatag ttacccgctc actttcggcg gagggaccaa ggtggagatc      720

aaaatcaaaa                                                             730


<210>  49
<211>  1507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B3L2F5 Extracellular domain

<400>  49
gatatccagc tgacccaatc accgtcgtcc ctgtctgcct ccgtgggcga ccgggtgacg       60

atcacctgta gtgcctcgag cagtgtacgg ttcatccact ggtaccaaca gaagcccggc      120

aaggcaccaa agcggctgat ctacgacacc agcaagctgg cgtctggggt gcccagcagg      180

ttctcgggaa gtggtagtgg cacagacttc actctcacca tcagttcact ccagccggag      240

gactttgcca cctactattg ccagcagtgg tcctcgtccc cctttacctt cggccaggga      300

acaaaggtgg aaattaaggg ttcgacctcc ggggggggct ccggtggggg ctccggcggg      360

gggggctcat cggaggttca gctggtggag agcggcggcg gcctggtgca gcccggcggg      420

agtctgcggc tgtcctgtgc cgccagcggc ttcaacatca aggactacta cattcactgg      480

gtgcggcaag ccccaggcaa gggtctggag tgggtggctt ggattgaccc tgaaaacggc      540

gacactgagt tcgtgccaaa attccagggg cgggcgacca tctccgccga cacctccaag      600

aatacggcct acctgcagat gaactccctg cgcgccgaag acacagcggt ctactactgc      660

aagacagggg gtttctgggg ccagggcacc ctcgtgaccg tttcgagtgc cgccggcgga      720

ggtggtggat ccggcggagg gggaagtggc gggggtgggt ccggcggcgg cggctcggag      780

gtgcagctgg tgcagtctgg agcagaggtg aaaaagcccg gggagtctct gaagatctcc      840

tgtaagggtt ctggatacag ttttaccagc aactggatcg gctgggtgcg ccagatgccc      900

gggaaaggcc tggagtggat ggggatcatc tatcctggtg actctgatac cagatacagc      960

ccgtccttcc aaggccaggt caccatctca gccgacaagt ccatcagcac cgcctacctg     1020

cagtggaaca gcctgaaggc ctcggacacc gccatgtatt actgtgcgag acaaactggt     1080

ttcctctggt ccttcgatct ctggggccgt ggcaccctgg tcactgtctc ctcaggtggc     1140

ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg ccatccagtt gacccagtct     1200

ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgccg ggcaagtcag     1260

gacattagca gtgctttagc ctggtatcag cagaaaccgg ggaaagctcc taagctcctg     1320

atctatgatg cctccagttt ggaaagtggg gtcccatcaa ggttcagcgg cagtggatct     1380

gggacagatt tcactctcac catcagcagc ctgcagcctg aagattttgc aacttattac     1440

tgtcaacagt ttaatagtta cccgctcact ttcggcggag ggaccaaggt ggagatcaaa     1500

atcaaaa                                                               1507


<210>  50
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3L2F5 Extracellular domain

<400>  50

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp 
                165                 170                 175     


Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly 
    210                 215                 220                 


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            260                 265                 270         


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        275                 280                 285             


Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    290                 295                 300                 


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
305                 310                 315                 320 


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                325                 330                 335     


Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu Trp 
        355                 360                 365             


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser 
385                 390                 395                 400 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                405                 410                 415     


Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys 
            420                 425                 430         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu 
        435                 440                 445             


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    450                 455                 460                 


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
465                 470                 475                 480 


Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys 
                485                 490                 495     


Val Glu Ile Lys Ile Lys 
            500         


<210>  51
<211>  1462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B3S2F5 Extracellular domain

<400>  51
gatatccagc tgacccaatc accgtcgtcc ctgtctgcct ccgtgggcga ccgggtgacg       60

atcacctgta gtgcctcgag cagtgtacgg ttcatccact ggtaccaaca gaagcccggc      120

aaggcaccaa agcggctgat ctacgacacc agcaagctgg cgtctggggt gcccagcagg      180

ttctcgggaa gtggtagtgg cacagacttc actctcacca tcagttcact ccagccggag      240

gactttgcca cctactattg ccagcagtgg tcctcgtccc cctttacctt cggccaggga      300

acaaaggtgg aaattaaggg ttcgacctcc ggggggggct ccggtggggg ctccggcggg      360

gggggctcat cggaggttca gctggtggag agcggcggcg gcctggtgca gcccggcggg      420

agtctgcggc tgtcctgtgc cgccagcggc ttcaacatca aggactacta cattcactgg      480

gtgcggcaag ccccaggcaa gggtctggag tgggtggctt ggattgaccc tgaaaacggc      540

gacactgagt tcgtgccaaa attccagggg cgggcgacca tctccgccga cacctccaag      600

aatacggcct acctgcagat gaactccctg cgcgccgaag acacagcggt ctactactgc      660

aagacagggg gtttctgggg ccagggcacc ctcgtgaccg tttcgagtgc cgccggcgga      720

ggtggtggat ccgaggtgca gctggtgcag tctggagcag aggtgaaaaa gcccggggag      780

tctctgaaga tctcctgtaa gggttctgga tacagtttta ccagcaactg gatcggctgg      840

gtgcgccaga tgcccgggaa aggcctggag tggatgggga tcatctatcc tggtgactct      900

gataccagat acagcccgtc cttccaaggc caggtcacca tctcagccga caagtccatc      960

agcaccgcct acctgcagtg gaacagcctg aaggcctcgg acaccgccat gtattactgt     1020

gcgagacaaa ctggtttcct ctggtccttc gatctctggg gccgtggcac cctggtcact     1080

gtctcctcag gtggcggtgg ctcgggcggt ggtgggtcgg gtggcggcgg atctgccatc     1140

cagttgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact     1200

tgccgggcaa gtcaggacat tagcagtgct ttagcctggt atcagcagaa accggggaaa     1260

gctcctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc atcaaggttc     1320

agcggcagtg gatctgggac agatttcact ctcaccatca gcagcctgca gcctgaagat     1380

tttgcaactt attactgtca acagtttaat agttacccgc tcactttcgg cggagggacc     1440

aaggtggaga tcaaaatcaa aa                                              1462


<210>  52
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3S2F5 Extracellular domain

<400>  52

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp 
                165                 170                 175     


Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly 
    210                 215                 220                 


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
                245                 250                 255     


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
            260                 265                 270         


Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
        275                 280                 285             


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
    290                 295                 300                 


Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
305                 310                 315                 320 


Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala 
                325                 330                 335     


Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp Leu 
            340                 345                 350         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln 
    370                 375                 380                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
385                 390                 395                 400 


Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln 
                405                 410                 415     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu 
            420                 425                 430         


Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        435                 440                 445             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    450                 455                 460                 


Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr 
465                 470                 475                 480 


Lys Val Glu Ile Lys Ile Lys 
                485         


<210>  53
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  53
ggcggcggcg gcagc                                                        15


<210>  54
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  54
ggcggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc       60

agc                                                                     63


<210>  55
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFBRII.dn

<400>  55
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac      120

aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc      180

tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca      240

caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt      300

tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag      360

tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct      420

gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg      480

ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata      540

tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcatcc      600

gga                                                                    603


<210>  56
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFBRII.dn

<400>  56

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Ser Gly 
        195                 200     


<210>  57
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD1CTMCD28 switch

<400>  57
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg ttttgggtgc tggtggtggt tggtggagtc      540

ctggcttgct atagcttgct agtaacagtg gcctttatta ttttctgggt gaggagtaag      600

aggagcaggc tcctgcacag tgactacatg aacatgactc cccgccgccc cgggcccacc      660

cgcaagcatt accagcccta tgccccacca cgcgacttcg cagcctatcg ctcc            714


<210>  58
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD1CTMCD28 switch

<400>  58

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val 
                165                 170                 175     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            180                 185                 190         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        195                 200                 205             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    210                 215                 220                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235             


<210>  59
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIFNgRIL12rb1 switch

<400>  59
atggctctcc tctttctcct accccttgtc atgcagggtg tgagcagggc tgagatgggc       60

accgcggatc tggggccgtc ctcagtgcct acaccaacta atgttacaat tgaatcctat      120

aacatgaacc ctatcgtata ttgggagtac cagatcatgc cacaggtccc tgtttttacc      180

gtagaggtaa agaactatgg tgttaagaat tcagaatgga ttgatgcctg catcaatatt      240

tctcatcatt attgtaatat ttctgatcat gttggtgatc catcaaattc tctttgggtc      300

agagttaaag ccagggttgg acaaaaagaa tctgcctatg caaagtcaga agaatttgct      360

gtatgccgag atggaaaaat tggaccacct aaactggata tcagaaagga ggagaagcaa      420

atcatgattg acatatttca cccttcagtt tttgtaaatg gagacgagca ggaagtcgat      480

tatgatcccg aaactacctg ttacattagg gtgtacaatg tgtatgtgag aatgaacgga      540

agtgagatcc agtataaaat actcacgcag aaggaagatg attgtgacga gattcagtgc      600

cagttagcga ttccagtatc ctcactgaat tctcagtact gtgtttcagc agaaggagtc      660

ttacatgtgt ggggtgttac aactgaaaag tcaaaagaag tttgtattac cattttcaat      720

agcagtataa aaggttctct ttggattcca gttgttgctg ctttactact ctttctagtg      780

cttagcctgg tattcatcag ggccgcacgg cacctgtgcc cgccgctgcc cacaccctgt      840

gccagctccg ccattgagtt ccctggaggg aaggagactt ggcagtggat caacccagtg      900

gacttccagg aagaggcatc cctgcaggag gccctggtgg tagagatgtc ctgggacaaa      960

ggcgagagga ctgagcctct cgagaagaca gagctacctg agggtgcccc tgagctggcc     1020

ctggatacag agttgtcctt ggaggatgga gacaggtgca aggccaagat gtga           1074


<210>  60
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIFNgRIL12rb1 switch

<400>  60

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
1               5                   10                  15      


Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
            20                  25                  30          


Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
        35                  40                  45              


Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
    50                  55                  60                  


Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile 
65                  70                  75                  80  


Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn 
                85                  90                  95      


Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala 
            100                 105                 110         


Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly 
        115                 120                 125             


Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp 
    130                 135                 140                 


Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp 
145                 150                 155                 160 


Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val 
                165                 170                 175     


Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu 
            180                 185                 190         


Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser 
        195                 200                 205             


Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp 
    210                 215                 220                 


Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn 
225                 230                 235                 240 


Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu 
                245                 250                 255     


Leu Phe Leu Val Leu Ser Leu Val Phe Ile Arg Ala Ala Arg His Leu 
            260                 265                 270         


Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe Pro 
        275                 280                 285             


Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln Glu 
    290                 295                 300                 


Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp Lys 
305                 310                 315                 320 


Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly Ala 
                325                 330                 335     


Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp Arg 
            340                 345                 350         


Cys Lys Ala Lys Met 
        355         


<210>  61
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIFNgbIL12rb2 switch

<400>  61
atgcgaccga cgctgctgtg gtcgctgctg ctgctgctcg gagtcttcgc cgccgccgcc       60

gcggccccgc cagaccctct ttcccagctg cccgctcctc agcacccgaa gattcgcctg      120

tacaacgcag agcaggtcct gagttgggag ccagtggccc tgagcaatag cacgaggcct      180

gttgtctacc aagtgcagtt taaatacacc gacagtaaat ggttcacggc cgacatcatg      240

tccatagggg tgaattgtac acagatcaca gcaacagagt gtgacttcac tgccgccagt      300

ccctcagcag gcttcccaat ggatttcaat gtcactctac gccttcgagc tgagctggga      360

gcactccatt ctgcctgggt gacaatgcct tggtttcaac actatcggaa tgtgactgtc      420

gggcctccag aaaacattga ggtgacccca ggagaaggct ccctcatcat caggttctcc      480

tctccctttg acatcgctga tacctccacg gccttttttt gttattatgt ccattactgg      540

gaaaaaggag gaatccaaca ggtcaaaggc cctttcagaa gcaactccat ttcattggat      600

aacttaaaac cctccagagt gtactgttta caagtccagg cacaactgct ttggaacaaa      660

agtaacatct ttagagtcgg gcatttaagc aacatatctt gctacgaaac aatggcagat      720

gcctccactg agcttcagca agtcatcctg atctccgtgg gaacattttc gttgctgtcg      780

gtgctggcag gagcctgttt cttcctggtc ctgaaatatc agcaaaaggt gtttgttctc      840

ctagcagccc tcagacctca gtggtgtagc agagaaattc cagatccagc aaatagcact      900

tgcgctaaga aatatcccat tgcagaggag aagacacagc tgcccttgga caggctcctg      960

atagactggc ccacgcctga agatcctgaa ccgctggtca tcagtgaagt ccttcatcaa     1020

gtgaccccag ttttcagaca tcccccctgc tccaactggc cacaaaggga aaaaggaatc     1080

caaggtcatc aggcctctga gaaagacatg atgcacagtg cctcaagccc accacctcca     1140

agagctctcc aagctgagag cagacaactg gtggatctgt acaaggtgct ggagagcagg     1200

ggctccgacc caaagccaga aaacccagcc tgtccctgga cggtgctccc agcaggtgac     1260

cttcccaccc atgatggcta cttaccctcc aacatagatg acctcccctc acatgaggca     1320

cctctcgctg actctctgga agaactggag cctcagcaca tctccctttc tgttttcccc     1380

tcaagttctc ttcacccact caccttctcc tgtggtgata agctgactct ggatcagtta     1440

aagatgaggt gtgactccct catgctctga                                      1470


<210>  62
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIFNgbIL12rb2 switch

<400>  62

Met Arg Pro Thr Leu Leu Trp Ser Leu Leu Leu Leu Leu Gly Val Phe 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Pro Pro Asp Pro Leu Ser Gln Leu Pro Ala 
            20                  25                  30          


Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser 
        35                  40                  45              


Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg Pro Val Val Tyr Gln 
    50                  55                  60                  


Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe Thr Ala Asp Ile Met 
65                  70                  75                  80  


Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala Thr Glu Cys Asp Phe 
                85                  90                  95      


Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met Asp Phe Asn Val Thr 
            100                 105                 110         


Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His Ser Ala Trp Val Thr 
        115                 120                 125             


Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr Val Gly Pro Pro Glu 
    130                 135                 140                 


Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu Ile Ile Arg Phe Ser 
145                 150                 155                 160 


Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala Phe Phe Cys Tyr Tyr 
                165                 170                 175     


Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln Val Lys Gly Pro Phe 
            180                 185                 190         


Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys Pro Ser Arg Val Tyr 
        195                 200                 205             


Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn Lys Ser Asn Ile Phe 
    210                 215                 220                 


Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr Glu Thr Met Ala Asp 
225                 230                 235                 240 


Ala Ser Thr Glu Leu Gln Gln Val Ile Leu Ile Ser Val Gly Thr Phe 
                245                 250                 255     


Ser Leu Leu Ser Val Leu Ala Gly Ala Cys Phe Phe Leu Val Leu Lys 
            260                 265                 270         


Tyr Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp 
        275                 280                 285             


Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys 
    290                 295                 300                 


Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu 
305                 310                 315                 320 


Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu 
                325                 330                 335     


Val Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn 
            340                 345                 350         


Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys 
        355                 360                 365             


Asp Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala Leu Gln 
    370                 375                 380                 


Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu Ser Arg 
385                 390                 395                 400 


Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr Val Leu 
                405                 410                 415     


Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile 
            420                 425                 430         


Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu 
        435                 440                 445             


Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu 
    450                 455                 460                 


His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu 
465                 470                 475                 480 


Lys Met Arg Cys Asp Ser Leu Met Leu 
                485                 


<210>  63
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  10A5 1412 aPDL1 aCd28 bispecific Ab

<400>  63
atgggctgga gttgcatcat tctcttcctc gtggcgaccg caacaggggt gcactccgac       60

atccagatga cccagtcccc gagttccctg tctgcttccg tgggagatcg cgtgactatc      120

acctgccggg cttcccaggg catctcttcc tggctggcgt ggtaccagca gaaaccagaa      180

aaggctccta agtccctgat ctacgcagct tcgtccctcc aatccggcgt cccctctcgc      240

ttctccggct ccggatccgg caccgacttc acgctgacaa tctcgagttt gcagcccgag      300

gacttcgcca cctactactg ccagcagtac aactcctacc cttacacctt cggccagggc      360

acaaagctcg aaatcaagtc gggggggggc gggtcgcagg tccagctggt gcagtccggc      420

gccgaagtca agaagcccgg agcaagtgtg aaagtgtcgt gcaaggcaag tgggtatacc      480

ttcacctcat acgacgtaca ctgggtgcgc caggcgcccg gtcagcgcct tgagtggatg      540

ggctggctcc acgccgacac cggcattacc aagttctctc agaagttcca gggaagagtg      600

accataacac gcgacaccag tgcttccaca gcttacatgg aactttcgag tctgagatcc      660

gaggacacag ccgtgtatta ctgtgcccgt gagcgcatcc agctgtggtt cgactactgg      720

gggcagggca ccctcgtgac ggtgtcgtcg gggggcgggg ggagtcaggt gcagctggtg      780

cagtccggag ccgaggtaaa gaagccaggc gcttccgtca aggtgtcatg caaggcctca      840

ggctacacct tcacaagcta ttacatccac tgggtgcgcc aagctcccgg tcagggcttg      900

gagtggatcg ggtgcattta cccagggaac gtcaacacaa actacaacga gaagttcaag      960

gatcgggcaa ccctgaccgt ggacacatcc atctctaccg cctacatgga gctgtcacgc     1020

ctgcgctctg atgacaccgc agtgtacttc tgtaccagga gtcactacgg cctggactgg     1080

aactttgatg tctggggcca gggaaccacc gtgacggtgt ccagtgtgga gggcggtagt     1140

ggcggctctg gtgggtccgg aggctcaggc ggcgtgatgg atgacattca gatgacccag     1200

agtccctcct ccctctccgc ttccgtcgga gaccgcgtga ccatcacttg tcacgcctca     1260

cagaatatct acgtgtggct gaactggtac caacagaagc ccggcaaggc ccccaagctg     1320

cttatctata aagcgtccaa cctccacacg ggagtccctt cccgcttctc cggatccggc     1380

agtgggacgg acttcacact cacaatctcg tcgctgcagc cagaggactt tgcgacgtac     1440

tactgccagc agggccagac ctacccatat actttcggcg gcgggaccaa ggtggagatt     1500

aag                                                                   1503


<210>  64
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10A5 1412 aPDL1 aCd28 bispecific Ab

<400>  64

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
        35                  40                  45              


Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys 
    50                  55                  60                  


Ser Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser 
            100                 105                 110         


Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Asp Val His Trp Val Arg Gln Ala Pro Gly Gln Arg 
                165                 170                 175     


Leu Glu Trp Met Gly Trp Leu His Ala Asp Thr Gly Ile Thr Lys Phe 
            180                 185                 190         


Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala 
        195                 200                 205             


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Glu Arg Ile Gln Leu Trp Phe Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr 
        275                 280                 285             


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
305                 310                 315                 320 


Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr Met 
                325                 330                 335     


Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys Thr 
            340                 345                 350         


Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln Gly 
        355                 360                 365             


Thr Thr Val Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ser Gly Gly Val Met Asp Asp Ile Gln Met Thr Gln 
385                 390                 395                 400 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
                405                 410                 415     


Cys His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu 
        435                 440                 445             


His Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
                485                 490                 495     


Lys Val Glu Ile Lys 
            500     


<210>  65
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGFB 1412 aTGFbRII aCd28 bispecific Ab

<400>  65
atgggttggt cctgcatcat cctgtttctc gtggccaccg ccaccggcgt gcactccgaa       60

attgtgttga cacagtctcc agccaccctg tctttgtctc caggggaaag agccaccctc      120

tcctgcaggg ccagtcagag tgttagaagt ttcttagcct ggtaccaaca gaaacctggc      180

caggctccca ggctcctcat ctatgatgca tccaacaggg ccactggcat cccagccagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      300

gattttgcag tttattactg tcagcagcgt agcaactggc ctccgacgtt cggccaaggg      360

accaaggtgg aaatcaaaag tggagggggc ggttcacagc tacagctgca ggagtcgggc      420

ccaggactgg tgaagccttc ggagacccta tccctcacct gcactgtctc tggtggctcc      480

atcagcagta gtagttactc ctggggctgg atccgccagc ccccagggaa gggcctggag      540

tggattggga gtttctatta cagtgggatc acctactaca gcccgtccct caagagtcga      600

attatcatat ccgaagacac gtccaagaac cagttctccc tgaagctgag ttctgtgacc      660

gccgcagaca cggctgtgta ttactgtgcg agcgggttta ctatgattcg gggagccctt      720

gactactggg gccagggaac cctg                                             744


<210>  66
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFB 1412 aTGFbRII aCd28 bispecific Ab

<400>  66

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
        35                  40                  45              


Arg Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
            100                 105                 110         


Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
145                 150                 155                 160 


Ile Ser Ser Ser Ser Tyr Ser Trp Gly Trp Ile Arg Gln Pro Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Ile Gly Ser Phe Tyr Tyr Ser Gly Ile Thr Tyr 
            180                 185                 190         


Tyr Ser Pro Ser Leu Lys Ser Arg Ile Ile Ile Ser Glu Asp Thr Ser 
        195                 200                 205             


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Gly Phe Thr Met Ile Arg Gly Ala Leu 
225                 230                 235                 240 


Asp Tyr Trp Gly Gln Gly Thr Leu 
                245             


<210>  67
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA 2F5BBZ CAR

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg 
65                  70                  75                  80  


Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser 
                85                  90                  95      


Ile Ser Thr Ala Tyr Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Phe Asp 
        115                 120                 125             


Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser 
        195                 200                 205             


Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 HCDR1

<400>  68

Glu Tyr Thr Ile His 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 HCDR2

<400>  69

Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Asp 
    


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 HCDR3

<400>  70

Gly Trp Asn Phe Asp Tyr 
1               5       


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 LCDR1

<400>  71

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Asp 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 LCDR2

<400>  72

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 LCDR3

<400>  73

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  74
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591 VH

<400>  74
gaggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata cacattcact gaatacacca tccactgggt gaggcaggcc      120

cctggaaagg gccttgagtg gattggaaac attaatccta acaatggtgg tactacctac      180

aaccagaagt tcgaggacag agtcacaatc actgtagaca agtccaccag cacagcctac      240

atggagctca gcagcctgag atctgaggat actgcagtct attactgtgc agctggttgg      300

aactttgact actggggcca aggcaccacg gtcaccgtct cctca                      345


<210>  75
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 VH

<400>  75

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  76
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591 VL

<400>  76
gacattcaga tgacccagtc tcccagcacc ctgtccgcat cagtaggaga cagggtcacc       60

atcacttgca aggccagtca ggatgtgggt actgctgtag actggtatca acagaaacca      120

gggcaagctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag actgcagcct      240

gaagactttg cagtttatta ctgtcagcaa tataacagct atcctctcac gttcggccag      300

gggaccaagg tggatatcaa a                                                321


<210>  77
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 VL

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  78
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 scFv VLVH

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn 
                165                 170                 175     


Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Arg Val Thr Ile 
            180                 185                 190         


Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe 
    210                 215                 220                 


Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
225                 230                 235         


<210>  79
<211>  2247
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2B3hJ591.BBZ bispecific CAR

<400>  79
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagcca ccatggcgct accggtgacc gcactcctgc tgccactcgc cctcctgctc      120

cacgccgccc gccccgatat ccagctgacc caatcaccgt cgtccctgtc tgcctccgtg      180

ggcgaccggg tgacgatcac ctgtagtgcc tcgagcagtg tacggttcat ccactggtac      240

caacagaagc ccggcaaggc accaaagcgg ctgatctacg acaccagcaa gctggcgtct      300

ggggtgccca gcaggttctc gggaagtggt agtggcacag acttcactct caccatcagt      360

tcactccagc cggaggactt tgccacctac tattgccagc agtggtcctc gtcccccttt      420

accttcggcc agggaacaaa ggtggaaatt aagggttcga cctccggggg gggctccggt      480

gggggctccg gcgggggggg ctcatcggag gttcagctgg tggagagcgg cggcggcctg      540

gtgcagcccg gcgggagtct gcggctgtcc tgtgccgcca gcggcttcaa catcaaggac      600

tactacattc actgggtgcg gcaagcccca ggcaagggtc tggagtgggt ggcttggatt      660

gaccctgaaa acggcgacac tgagttcgtg ccaaaattcc aggggcgggc gaccatctcc      720

gccgacacct ccaagaatac ggcctacctg cagatgaact ccctgcgcgc cgaagacaca      780

gcggtctact actgcaagac agggggtttc tggggccagg gcaccctcgt gaccgtttcg      840

agtgccgccg gcggaggtgg tggatccgac attcagatga cccagtctcc cagcaccctg      900

tccgcatcag taggagacag ggtcaccatc acttgcaagg ccagtcagga tgtgggtact      960

gctgtagact ggtatcaaca gaaaccaggg caagctccta aactactgat ttactgggca     1020

tccacccggc acactggagt ccctgatcgc ttcagcggca gtggatctgg gacagatttc     1080

actctcacca tcagcagact gcagcctgaa gactttgcag tttattactg tcagcaatat     1140

aacagctatc ctctcacgtt cggccagggg accaaggtgg atatcaaagg aggcggagga     1200

tctggcggcg gaggaagttc tggcggaggc agcgaggtcc agctggtgca gtctggagct     1260

gaggtgaaga agcctggggc ctcagtgaag gtctcctgca aggcttctgg atacacattc     1320

actgaataca ccatccactg ggtgaggcag gcccctggaa agggccttga gtggattgga     1380

aacattaatc ctaacaatgg tggtactacc tacaaccaga agttcgagga cagagtcaca     1440

atcactgtag acaagtccac cagcacagcc tacatggagc tcagcagcct gagatctgag     1500

gatactgcag tctattactg tgcagctggt tggaactttg actactgggg ccaaggcacc     1560

acggtcaccg tctcctcaaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac     1620

catgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca     1680

gtgcacacga gggggctgga cttcgcctgt gatatctaca tctgggcgcc cttggccggg     1740

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1800

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1860

gacggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1920

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1980

ctcaatctag gacgaagaga ggagtacgac gttttggaca agagacgtgg ccgggaccct     2040

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa cgaactgcag     2100

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     2160

aaggggcacg acggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     2220

cttcacatgc aggccctgcc ccctcgc                                         2247


<210>  80
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3hJ591.BBZ bispecific CAR

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ala Thr Met Ala Leu Pro Val Thr Ala Leu 
            20                  25                  30          


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln 
        35                  40                  45              


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    50                  55                  60                  


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile His Trp Tyr 
65                  70                  75                  80  


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser 
                85                  90                  95      


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
            100                 105                 110         


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
        115                 120                 125             


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr Phe Gly Gln 
    130                 135                 140                 


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val Glu Ser 
                165                 170                 175     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            180                 185                 190         


Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln 
        195                 200                 205             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn 
    210                 215                 220                 


Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile Ser 
225                 230                 235                 240 


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
                245                 250                 255     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly Phe Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Gly Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
    290                 295                 300                 


Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr 
305                 310                 315                 320 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
                325                 330                 335     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln 
        355                 360                 365             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
    370                 375                 380                 


Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                405                 410                 415     


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
            420                 425                 430         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
        435                 440                 445             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
    450                 455                 460                 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Arg Val Thr 
465                 470                 475                 480 


Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
                485                 490                 495     


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
            500                 505                 510         


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Asn His 
        515                 520                 525             


Asp Ala Ser Ala Ala Thr Thr Asn Thr Gly Ala His His Ala Ser Gln 
    530                 535                 540                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
545                 550                 555                 560 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                565                 570                 575     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            580                 585                 590         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        595                 600                 605             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    610                 615                 620                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
625                 630                 635                 640 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                645                 650                 655     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            660                 665                 670         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        675                 680                 685             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    690                 695                 700                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
705                 710                 715                 720 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                725                 730                 735     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 


<210>  81
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3hJ591.BBZ bispecific CAR

<400>  81

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ala Thr Met Ala Leu Pro Val Thr Ala Leu 
            20                  25                  30          


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln 
        35                  40                  45              


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    50                  55                  60                  


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile His Trp Tyr 
65                  70                  75                  80  


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser 
                85                  90                  95      


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
            100                 105                 110         


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
        115                 120                 125             


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr Phe Gly Gln 
    130                 135                 140                 


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val Glu Ser 
                165                 170                 175     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            180                 185                 190         


Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln 
        195                 200                 205             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn 
    210                 215                 220                 


Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile Ser 
225                 230                 235                 240 


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
                245                 250                 255     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly Phe Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Gly Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
    290                 295                 300                 


Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr 
305                 310                 315                 320 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
                325                 330                 335     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln 
        355                 360                 365             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
    370                 375                 380                 


Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                405                 410                 415     


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
            420                 425                 430         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
        435                 440                 445             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
    450                 455                 460                 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Arg Val Thr 
465                 470                 475                 480 


Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
                485                 490                 495     


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
            500                 505                 510         


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser His Thr 
        515                 520                 525             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    530                 535                 540                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
545                 550                 555                 560 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                565                 570                 575     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            580                 585                 590         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        595                 600                 605             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    610                 615                 620                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
625                 630                 635                 640 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                645                 650                 655     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            660                 665                 670         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        675                 680                 685             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    690                 695                 700                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
705                 710                 715                 720 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                725                 730                 735     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 


<210>  82
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3hJ591.BBZ bispecific CAR

<400>  82

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ala Thr Met Ala Leu Pro Val Thr Ala Leu 
            20                  25                  30          


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Gln 
        35                  40                  45              


Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    50                  55                  60                  


Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile His Trp Tyr 
65                  70                  75                  80  


Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser 
                85                  90                  95      


Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
            100                 105                 110         


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
        115                 120                 125             


Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr Phe Gly Gln 
    130                 135                 140                 


Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu Val Glu Ser 
                165                 170                 175     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            180                 185                 190         


Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp Val Arg Gln 
        195                 200                 205             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp Pro Glu Asn 
    210                 215                 220                 


Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala Thr Ile Ser 
225                 230                 235                 240 


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
                245                 250                 255     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly Phe Trp Gly 
            260                 265                 270         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Gly Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
    290                 295                 300                 


Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr 
305                 310                 315                 320 


Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
                325                 330                 335     


Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser 
            340                 345                 350         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln 
        355                 360                 365             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro 
    370                 375                 380                 


Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
                405                 410                 415     


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
            420                 425                 430         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
        435                 440                 445             


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
    450                 455                 460                 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Arg Val Thr 
465                 470                 475                 480 


Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
                485                 490                 495     


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
            500                 505                 510         


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Thr Thr 
        515                 520                 525             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    530                 535                 540                 


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
545                 550                 555                 560 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
                565                 570                 575     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            580                 585                 590         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        595                 600                 605             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    610                 615                 620                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
625                 630                 635                 640 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                645                 650                 655     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            660                 665                 670         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        675                 680                 685             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    690                 695                 700                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
705                 710                 715                 720 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                725                 730                 735     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            740                 745                 


<210>  83
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591 scFv VLVH

<400>  83
gacattcaga tgacccagtc tcccagcacc ctgtccgcat cagtaggaga cagggtcacc       60

atcacttgca aggccagtca ggatgtgggt actgctgtag actggtatca acagaaacca      120

gggcaagctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag actgcagcct      240

gaagactttg cagtttatta ctgtcagcaa tataacagct atcctctcac gttcggccag      300

gggaccaagg tggatatcaa aggaggcgga ggatctggcg gcggaggaag ttctggcgga      360

ggcagcgagg tccagctggt gcagtctgga gctgaggtga agaagcctgg ggcctcagtg      420

aaggtctcct gcaaggcttc tggatacaca ttcactgaat acaccatcca ctgggtgagg      480

caggcccctg gaaagggcct tgagtggatt ggaaacatta atcctaacaa tggtggtact      540

acctacaacc agaagttcga ggacagagtc acaatcactg tagacaagtc caccagcaca      600

gcctacatgg agctcagcag cctgagatct gaggatactg cagtctatta ctgtgcagct      660

ggttggaact ttgactactg gggccaaggc accacggtca ccgtctcctc a               711


<210>  84
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 scFv VLVH no linker

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Glu Val Gln Leu Val 
            100                 105                 110         


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
        115                 120                 125             


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val 
    130                 135                 140                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro 
145                 150                 155                 160 


Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
            180                 185                 190         


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn 
        195                 200                 205             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    210                 215                 220         


<210>  85
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591 scFv VHVL

<400>  85

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly 
145                 150                 155                 160 


Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu 
                165                 170                 175     


Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr 
    210                 215                 220                 


Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
225                 230                 235         


<210>  86
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591 scFv VHVL

<400>  86
gaggtccagc tggtgcagtc tggagctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata cacattcact gaatacacca tccactgggt gaggcaggcc      120

cctggaaagg gccttgagtg gattggaaac attaatccta acaatggtgg tactacctac      180

aaccagaagt tcgaggacag agtcacaatc actgtagaca agtccaccag cacagcctac      240

atggagctca gcagcctgag atctgaggat actgcagtct attactgtgc agctggttgg      300

aactttgact actggggcca aggcaccacg gtcaccgtct cctcaggagg cggaggatct      360

ggcggcggag gaagttctgg cggaggcagc gacattcaga tgacccagtc tcccagcacc      420

ctgtccgcat cagtaggaga cagggtcacc atcacttgca aggccagtca ggatgtgggt      480

actgctgtag actggtatca acagaaacca gggcaagctc ctaaactact gatttactgg      540

gcatccaccc ggcacactgg agtccctgat cgcttcagcg gcagtggatc tgggacagat      600

ttcactctca ccatcagcag actgcagcct gaagactttg cagtttatta ctgtcagcaa      660

tataacagct atcctctcac gttcggccag gggaccaagg tggatatcaa a               711


<210>  87
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591VHVK.BBZ

<400>  87

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Tyr Thr Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr 
65                  70                  75                  80  


Thr Tyr Asn Gln Lys Phe Glu Asp Arg Val Thr Ile Thr Val Asp Lys 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
145                 150                 155                 160 


Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
                165                 170                 175     


Ala Ser Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Gln Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr 
        195                 200                 205             


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 


Leu Thr Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Asp Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  88
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591VHVK.BBZ

<400>  88
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagagg tccagctggt gcagtctgga gctgaggtga agaagcctgg ggcctcagtg      120

aaggtctcct gcaaggcttc tggatacaca ttcactgaat acaccatcca ctgggtgagg      180

caggcccctg gaaagggcct tgagtggatt ggaaacatta atcctaacaa tggtggtact      240

acctacaacc agaagttcga ggacagagtc acaatcactg tagacaagtc caccagcaca      300

gcctacatgg agctcagcag cctgagatct gaggatactg cagtctatta ctgtgcagct      360

ggttggaact ttgactactg gggccaaggc accacggtca ccgtctcctc aggaggcgga      420

ggatctggcg gcggaggaag ttctggcgga ggcagcgaca ttcagatgac ccagtctccc      480

agcaccctgt ccgcatcagt aggagacagg gtcaccatca cttgcaaggc cagtcaggat      540

gtgggtactg ctgtagactg gtatcaacag aaaccagggc aagctcctaa actactgatt      600

tactgggcat ccacccggca cactggagtc cctgatcgct tcagcggcag tggatctggg      660

acagatttca ctctcaccat cagcagactg cagcctgaag actttgcagt ttattactgt      720

cagcaatata acagctatcc tctcacgttc ggccagggga ccaaggtgga tatcaaaacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      960

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1020

caaccattta tgagaccagt acaaactact caagaggaag acggctgtag ctgccgattt     1080

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1140

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1200

gagtacgacg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1260

aggaagaacc ctcaggaagg cctgtacaac gaactgcaga aagataagat ggcggaggcc     1320

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga cggcctttac     1380

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1440

cctcgc                                                                1446


<210>  89
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.BBZ

<400>  89

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
                165                 170                 175     


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  90
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.BBZ

<400>  90
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagaca ttcagatgac ccagtctccc agcaccctgt ccgcatcagt aggagacagg      120

gtcaccatca cttgcaaggc cagtcaggat gtgggtactg ctgtagactg gtatcaacag      180

aaaccagggc aagctcctaa actactgatt tactgggcat ccacccggca cactggagtc      240

cctgatcgct tcagcggcag tggatctggg acagatttca ctctcaccat cagcagactg      300

cagcctgaag actttgcagt ttattactgt cagcaatata acagctatcc tctcacgttc      360

ggccagggga ccaaggtgga tatcaaagga ggcggaggat ctggcggcgg aggaagttct      420

ggcggaggca gcgaggtcca gctggtgcag tctggagctg aggtgaagaa gcctggggcc      480

tcagtgaagg tctcctgcaa ggcttctgga tacacattca ctgaatacac catccactgg      540

gtgaggcagg cccctggaaa gggccttgag tggattggaa acattaatcc taacaatggt      600

ggtactacct acaaccagaa gttcgaggac agagtcacaa tcactgtaga caagtccacc      660

agcacagcct acatggagct cagcagcctg agatctgagg atactgcagt ctattactgt      720

gcagctggtt ggaactttga ctactggggc caaggcacca cggtcaccgt ctcctcaacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg      960

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1020

caaccattta tgagaccagt acaaactact caagaggaag acggctgtag ctgccgattt     1080

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1140

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1200

gagtacgacg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1260

aggaagaacc ctcaggaagg cctgtacaac gaactgcaga aagataagat ggcggaggcc     1320

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga cggcctttac     1380

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1440

cctcgc                                                                1446


<210>  91
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSBBZ

<400>  91

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
                165                 170                 175     


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
305                 310                 315                 320 


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
                325                 330                 335     


Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr 
            340                 345                 350         


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Lys Arg Gly Arg Lys 
        355                 360                 365             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    370                 375                 380                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
385                 390                 395                 400 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                405                 410                 415     


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            420                 425                 430         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        435                 440                 445             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Ala Leu Pro Pro Arg 
        515         


<210>  92
<211>  1551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSBBZ

<400>  92
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagaca ttcagatgac ccagtctccc agcaccctgt ccgcatcagt aggagacagg      120

gtcaccatca cttgcaaggc cagtcaggat gtgggtactg ctgtagactg gtatcaacag      180

aaaccagggc aagctcctaa actactgatt tactgggcat ccacccggca cactggagtc      240

cctgatcgct tcagcggcag tggatctggg acagatttca ctctcaccat cagcagactg      300

cagcctgaag actttgcagt ttattactgt cagcaatata acagctatcc tctcacgttc      360

ggccagggga ccaaggtgga tatcaaagga ggcggaggat ctggcggcgg aggaagttct      420

ggcggaggca gcgaggtcca gctggtgcag tctggagctg aggtgaagaa gcctggggcc      480

tcagtgaagg tctcctgcaa ggcttctgga tacacattca ctgaatacac catccactgg      540

gtgaggcagg cccctggaaa gggccttgag tggattggaa acattaatcc taacaatggt      600

ggtactacct acaaccagaa gttcgaggac agagtcacaa tcactgtaga caagtccacc      660

agcacagcct acatggagct cagcagcctg agatctgagg atactgcagt ctattactgt      720

gcagctggtt ggaactttga ctactggggc caaggcacca cggtcaccgt ctcctcaacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg atttctggtt acccatagga tgtgcagcct ttgttgtagt ctgcattttg      960

ggatgcatac ttatttgttg gcttacaaaa aagaagtatt catccagtgt gcacgaccct     1020

aacggtgaat acatgttcat gagagcagtg aacacagcca aaaaatccag actcacagat     1080

gtgaccctaa aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1140

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1200

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1260

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgacgttttg     1320

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1380

gaaggcctgt acaacgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1440

atgaaaggcg agcgccggag gggcaagggg cacgacggcc tttaccaggg tctcagtaca     1500

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              1551


<210>  93
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSBBZYMNM

<400>  93

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
                165                 170                 175     


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
305                 310                 315                 320 


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
                325                 330                 335     


Val His Asp Pro Asn Gly Glu Tyr Met Asn Met Arg Ala Val Asn Thr 
            340                 345                 350         


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Lys Arg Gly Arg Lys 
        355                 360                 365             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    370                 375                 380                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
385                 390                 395                 400 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                405                 410                 415     


Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            420                 425                 430         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        435                 440                 445             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    450                 455                 460                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
465                 470                 475                 480 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                485                 490                 495     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            500                 505                 510         


Ala Leu Pro Pro Arg 
        515         


<210>  94
<211>  1551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSBBZYMNM

<400>  94
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagaca ttcagatgac ccagtctccc agcaccctgt ccgcatcagt aggagacagg      120

gtcaccatca cttgcaaggc cagtcaggat gtgggtactg ctgtagactg gtatcaacag      180

aaaccagggc aagctcctaa actactgatt tactgggcat ccacccggca cactggagtc      240

cctgatcgct tcagcggcag tggatctggg acagatttca ctctcaccat cagcagactg      300

cagcctgaag actttgcagt ttattactgt cagcaatata acagctatcc tctcacgttc      360

ggccagggga ccaaggtgga tatcaaagga ggcggaggat ctggcggcgg aggaagttct      420

ggcggaggca gcgaggtcca gctggtgcag tctggagctg aggtgaagaa gcctggggcc      480

tcagtgaagg tctcctgcaa ggcttctgga tacacattca ctgaatacac catccactgg      540

gtgaggcagg cccctggaaa gggccttgag tggattggaa acattaatcc taacaatggt      600

ggtactacct acaaccagaa gttcgaggac agagtcacaa tcactgtaga caagtccacc      660

agcacagcct acatggagct cagcagcctg agatctgagg atactgcagt ctattactgt      720

gcagctggtt ggaactttga ctactggggc caaggcacca cggtcaccgt ctcctcaacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg atttctggtt acccatagga tgtgcagcct ttgttgtagt ctgcattttg      960

ggatgcatac ttatttgttg gcttacaaaa aagaagtatt catccagtgt gcacgaccct     1020

aacggtgaat acatgaacat gagagcagtg aacacagcca aaaaatccag actcacagat     1080

gtgaccctaa aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1140

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1200

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1260

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgacgttttg     1320

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1380

gaaggcctgt acaacgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1440

atgaaaggcg agcgccggag gggcaagggg cacgacggcc tttaccaggg tctcagtaca     1500

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              1551


<210>  95
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSZ

<400>  95

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
                165                 170                 175     


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
305                 310                 315                 320 


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
                325                 330                 335     


Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr 
            340                 345                 350         


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe Ser 
        355                 360                 365             


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
385                 390                 395                 400 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                405                 410                 415     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475 


<210>  96
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSZ

<400>  96
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagaca ttcagatgac ccagtctccc agcaccctgt ccgcatcagt aggagacagg      120

gtcaccatca cttgcaaggc cagtcaggat gtgggtactg ctgtagactg gtatcaacag      180

aaaccagggc aagctcctaa actactgatt tactgggcat ccacccggca cactggagtc      240

cctgatcgct tcagcggcag tggatctggg acagatttca ctctcaccat cagcagactg      300

cagcctgaag actttgcagt ttattactgt cagcaatata acagctatcc tctcacgttc      360

ggccagggga ccaaggtgga tatcaaagga ggcggaggat ctggcggcgg aggaagttct      420

ggcggaggca gcgaggtcca gctggtgcag tctggagctg aggtgaagaa gcctggggcc      480

tcagtgaagg tctcctgcaa ggcttctgga tacacattca ctgaatacac catccactgg      540

gtgaggcagg cccctggaaa gggccttgag tggattggaa acattaatcc taacaatggt      600

ggtactacct acaaccagaa gttcgaggac agagtcacaa tcactgtaga caagtccacc      660

agcacagcct acatggagct cagcagcctg agatctgagg atactgcagt ctattactgt      720

gcagctggtt ggaactttga ctactggggc caaggcacca cggtcaccgt ctcctcaacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg atttctggtt acccatagga tgtgcagcct ttgttgtagt ctgcattttg      960

ggatgcatac ttatttgttg gcttacaaaa aagaagtatt catccagtgt gcacgaccct     1020

aacggtgaat acatgttcat gagagcagtg aacacagcca aaaaatccag actcacagat     1080

gtgaccctaa gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1140

aaccagctct ataacgagct caatctagga cgaagagagg agtacgacgt tttggacaag     1200

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1260

ctgtacaacg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1320

ggcgagcgcc ggaggggcaa ggggcacgac ggcctttacc agggtctcag tacagccacc     1380

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1425


<210>  97
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSZYMNM

<400>  97

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
        35                  40                  45              


Gln Asp Val Gly Thr Ala Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Arg Leu Gln Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Asn Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Asp Ile 
        115                 120                 125             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
                165                 170                 175     


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
        195                 200                 205             


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
    210                 215                 220                 


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
305                 310                 315                 320 


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
                325                 330                 335     


Val His Asp Pro Asn Gly Glu Tyr Met Asn Met Arg Ala Val Asn Thr 
            340                 345                 350         


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu Arg Val Lys Phe Ser 
        355                 360                 365             


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
    370                 375                 380                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
385                 390                 395                 400 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                405                 410                 415     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475 


<210>  98
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hJ591VKVH.ICOSZYMNM

<400>  98
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca cgccgccaga       60

cctggagaca ttcagatgac ccagtctccc agcaccctgt ccgcatcagt aggagacagg      120

gtcaccatca cttgcaaggc cagtcaggat gtgggtactg ctgtagactg gtatcaacag      180

aaaccagggc aagctcctaa actactgatt tactgggcat ccacccggca cactggagtc      240

cctgatcgct tcagcggcag tggatctggg acagatttca ctctcaccat cagcagactg      300

cagcctgaag actttgcagt ttattactgt cagcaatata acagctatcc tctcacgttc      360

ggccagggga ccaaggtgga tatcaaagga ggcggaggat ctggcggcgg aggaagttct      420

ggcggaggca gcgaggtcca gctggtgcag tctggagctg aggtgaagaa gcctggggcc      480

tcagtgaagg tctcctgcaa ggcttctgga tacacattca ctgaatacac catccactgg      540

gtgaggcagg cccctggaaa gggccttgag tggattggaa acattaatcc taacaatggt      600

ggtactacct acaaccagaa gttcgaggac agagtcacaa tcactgtaga caagtccacc      660

agcacagcct acatggagct cagcagcctg agatctgagg atactgcagt ctattactgt      720

gcagctggtt ggaactttga ctactggggc caaggcacca cggtcaccgt ctcctcaacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg atttctggtt acccatagga tgtgcagcct ttgttgtagt ctgcattttg      960

ggatgcatac ttatttgttg gcttacaaaa aagaagtatt catccagtgt gcacgaccct     1020

aacggtgaat acatgaacat gagagcagtg aacacagcca aaaaatccag actcacagat     1080

gtgaccctaa gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag     1140

aaccagctct ataacgagct caatctagga cgaagagagg agtacgacgt tttggacaag     1200

agacgtggcc gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc     1260

ctgtacaacg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1320

ggcgagcgcc ggaggggcaa ggggcacgac ggcctttacc agggtctcag tacagccacc     1380

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1425


<210>  99
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  99

Asn His Asp Ala Ser Ala Ala Thr Thr Asn Thr Gly Ala His His Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  100
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  100

His Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  101
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH Consensus Sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is A or P

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is V or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa is A or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is R or K

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is N or Q

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa is V or A

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa is I or L

<400>  101

Glu Val Gln Leu Val Gln Ser Gly Xaa Glu Xaa Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Xaa Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Xaa Gln Ala Xaa Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Xaa Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Xaa Thr Xaa Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  102
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL Consensus Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Q or V

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is T or F

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa is S or T

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa is P or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa is V or D

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa is Y or F

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is K or M

<400>  102

Asp Ile Xaa Met Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Xaa 
65                  70                  75                  80  


Glu Asp Phe Ala Xaa Tyr Xaa Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Xaa Val Asp Ile Lys 
            100                 105         


<210>  103
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  103

Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  104
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL

<400>  104

Asp Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Met Val Asp Ile Lys 
            100                 105         


<210>  105
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  105

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  106
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL

<400>  106

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  107
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  107

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Ala Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  108
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL

<400>  108

Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  109
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  109

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Gln Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  110
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH Consensus Sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is A or P

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is V or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa is A or T

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa is R or K

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is P or H

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is N or Q

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa is V or A

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa is I or L

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa is L or P

<220>
<221>  misc_feature
<222>  (98)..(102)
<223>  Xaa-Xaa is AYWLF, GGWTF, or GAWTM

<400>  110

Glu Val Gln Leu Val Gln Ser Gly Xaa Glu Xaa Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Xaa Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Xaa Gln Ala Xaa Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Xaa Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Xaa Thr Xaa Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Xaa Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa Xaa Xaa Xaa Xaa Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  111
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL Consensus Sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Q or V

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is T or F

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa is S or T

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa is P or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa is V or D

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa is Y or F

<220>
<221>  misc_feature
<222>  (91)..(95)
<223>  Xaa-Xaa is FTRYP or YNAYS

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is K or M

<400>  111

Asp Ile Xaa Met Thr Gln Ser Pro Ser Xaa Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Xaa 
65                  70                  75                  80  


Glu Asp Phe Ala Xaa Tyr Xaa Cys Gln Gln Xaa Xaa Xaa Xaa Xaa Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Xaa Val Asp Ile Lys 
            100                 105         


<210>  112
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  112

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Tyr Trp Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  113
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  114
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  114

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Trp Thr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL

<400>  115

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Thr Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  116
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  116

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Trp Thr Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  117
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VL

<400>  117

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ala Tyr Ser Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  118
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMA VH

<400>  118

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Asn Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Glu Asp Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Pro Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Trp Asn Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  119

Gly Ser Gly Gly Ser 
1               5   


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  repeat n times, where n represents an integer of at least 1

<400>  120

Gly Gly Gly Ser 
1               


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  121

Gly Gly Gly Gly Ser 
1               5   


<210>  122
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  122

Gly Gly Ser Gly 
1               


<210>  123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  123

Gly Gly Ser Gly Gly 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  124

Gly Ser Gly Ser Gly 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  125

Gly Ser Gly Gly Gly 
1               5   


<210>  126
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  126

Gly Gly Gly Ser Gly 
1               5   


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  127

Gly Ser Ser Ser Gly 
1               5   


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  128

Gly Gly Gly Gly Ser 
1               5   


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  130
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  130
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210>  131
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  131

Asp Lys Thr His Thr 
1               5   


<210>  132
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  132

Cys Pro Pro Cys 
1               


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  133

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  134
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  134

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  135

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  136

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  137

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  138

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  139
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  139

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  140
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  140

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  141
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  141

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  142

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  143
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  143

Arg Xaa Lys Arg 
1               


<210>  144
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  144

Arg Xaa Arg Arg 
1               


<210>  145
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is K or R

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is K or R

<400>  145

Xaa Arg Xaa Xaa Arg 
1               5   


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  146

Arg Xaa Xaa Arg 
1               


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  147

Arg Gln Lys Arg 
1               


<210>  148
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2B3 scFv

<400>  148

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr Tyr Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Asp 
                165                 170                 175     


Pro Glu Asn Gly Asp Thr Glu Phe Val Pro Lys Phe Gln Gly Arg Ala 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Lys Thr Gly Gly 
    210                 215                 220                 


Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Gly 
225                 230                 235                 


