                         SEQUENCE LISTING

<110>  CYTOIMMUNE THERAPEUTICS, INC.
 
<120>  BISPECIFIC ANTIBODY CAR CELL IMMUNOTHERAPY

<130>  113086-0113

<150>  62/898,503
<151>  2019-09-10

<160>  174   

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1

Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Asp Pro Lys Gly Thr 
            20      


<210>  2
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  2

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  3
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  3

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  4

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  5

Met Gly Trp Ser Ser Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His 
        


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  6

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  7

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  8

Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  9

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  10

Arg Tyr Asp Gly Ser Asn 
1               5       


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  11

Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr 
1               5                   10          


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  12

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Phe Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  15

Arg Ala Ser Gln Ser Ile Ser Asn Asn Leu His 
1               5                   10      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  16

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Met 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  17

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  18

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  19

Gln Gln Ser Asn Thr Trp Pro Tyr Thr 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  20

Gln Asn Asp His Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  21

Ser Tyr Trp Met His 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  22

Asn Tyr Gly Leu His 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  23

Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  24

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  25

Ala Ile Thr Thr Thr Pro Phe Asp Phe 
1               5                   


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  26

Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  27
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  27

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Thr Trp Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  28
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Met Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp His Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  29
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  29

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Lys Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Lys Asp Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ile Thr Thr Thr Pro Phe Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  30
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  30

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Gly Gly Ile Tyr Tyr Ala Asn His Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  31

Arg Ser Ser Gln Asn Ile Val His Asn Asn Gly Ile Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  32

Arg Ala Ser Gln Gly Ile Arg Asn Asn Leu Ala 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  33

Lys Val Ser Asp Arg Phe Ser 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  34

Ala Ala Ser Asn Leu Gln Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  35

Phe Gln Gly Ser His Ile Pro Pro Thr 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  36

Leu Gln His His Ser Tyr Pro Leu Thr 
1               5                   


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  37

Gly Asp Thr Phe Thr Ser Tyr 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  38

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  39

Tyr Pro Gly Ser Gly Gly 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  40

Ser Gly Ser Gly Gly Ser 
1               5       


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  41

Ser Gly Gly Pro Tyr Phe Phe Asp Tyr 
1               5                   


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  42

Ser Ser Gly Trp Ser Glu Tyr 
1               5           


<210>  43
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  43

Asp Ile Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Asn 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Glu Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asp Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Ala 
        115 


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Val Glu Ile Lys Tyr Ala His Asn Ser 
            100                 105                 110         


<210>  45
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  45

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Met Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Pro Cys Lys Ala Ser Gly Asp Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg His Gly His Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Gly Gly Thr Asn Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Val Thr Leu Thr Val Asp Arg Ser Ser Arg Thr Val Tyr 
65                  70                  75                  80  


Met His Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Gly Gly Pro Tyr Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  46

Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Ser Gly Trp Ser Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  47

Arg Ala Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile His 
1               5                   10                  15  


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  48

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  49

Arg Ala Ser Glu Ser Val Thr Ile Leu Gly Ser His Leu Ile Tyr 
1               5                   10                  15  


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  50

Leu Ala Ser Asn Val Gln Thr 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  51

Tyr Thr Ser Asn Leu His Ser 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  52

Leu Ala Ser Asn Val Gln Thr 
1               5           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  53

Leu Gln Ser Arg Thr Ile Pro Arg Thr 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  54

Gln Gln Tyr Arg Lys Leu Pro Trp Thr 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  55

Leu Gln Ser Arg Thr Ile Pro Arg Thr 
1               5                   


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  56

Gly Tyr Thr Phe Thr Asp Tyr 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  57

Gly Gly Thr Phe Ser Asn Tyr 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  58

Gly Tyr Thr Phe Arg His Tyr 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  59

Ile Asn Thr Glu Thr Arg Glu 
1               5           


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  60

Tyr Arg Gly His Ser Asp 
1               5       


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  61

Asn Thr Glu Ser Gly Val 
1               5       


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  62

Asp Tyr Ser Tyr Ala Met Asp Tyr 
1               5               


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  63

Gly Ala Ile Tyr Asn Gly Tyr Asp Val Leu Asp Asn 
1               5                   10          


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  64

Asp Tyr Leu Tyr Ser Leu Asp Phe 
1               5               


<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  65

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  66
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  67
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  67

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu Gly 
1               5                   10                  15      


Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile Leu 
            20                  25                  30          


Gly Ser His Leu Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  68
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  68

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  69
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Tyr Asn Gly Tyr Asp Val Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  70
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  70

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg His Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Thr Glu Ser Gly Val Pro Ile Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Val Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Val Ile Asn Asn Leu Lys Asp Glu Asp Thr Ala Ser Tyr Phe Cys 
                85                  90                  95      


Ser Asn Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr Ala 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  71

Lys Ala Ser Gln Asp Val Ile Thr Gly Val Ala 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  72

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  73

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  74

Gly Tyr Ser Phe Thr Thr Tyr 
1               5           


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  75

His Pro Ser Asp Ser Glu 
1               5       


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  76

Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr 
1               5                   10      


<210>  77
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  77

Ser Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr 
            20                  25                  30          


Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln 
65                  70                  75                  80  


Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  78
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  78

Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  79

Ser Val Thr Val Ser Thr Gly Gln Gly Trp Tyr Asp Met Ala Arg Thr 
1               5                   10                  15      


Ala Ile Met Thr Ser Arg Ala Cys Tyr Tyr Val Ala Ser Asp Glu Ser 
            20                  25                  30          


Thr Pro Ser Ser Leu Gln Met Tyr Ala Thr Ser Ser Ser Lys Asp Val 
        35                  40                  45              


Thr Leu Thr Ala Lys Asp Lys Phe Lys Gln Asn Leu Arg Thr Glu Ser 
    50                  55                  60                  


Asp Ser Pro His Ile Met Gly Ile Trp Glu Leu Gly Gln Gly Pro Arg 
65                  70                  75                  80  


Gln Lys Val Trp Asn Met Trp Tyr Thr Thr Phe Ser Tyr Gly Ser Ala 
                85                  90                  95      


Lys Cys Ser Leu Lys Val Ser Ala Gly Pro Arg Val Leu Glu Ala Gly 
            100                 105                 110         


Pro Gln Gln Leu Gln Val Gln Ser 
        115                 120 


<210>  80
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  80

Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser 
        115                 120 


<210>  81
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  82
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  82

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  83
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  83

Pro Ser Gly Gln Ala Gly Ala Ala Ala Ser Glu Ser Leu Phe Val Ser 
1               5                   10                  15      


Asn His Ala Tyr 
            20  


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  84

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  85
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  85

His Val Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro 
            20              


<210>  86
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  86
atggggtggt caagcattat tctgtttctg gtcgctaccg ctacaggcgt ccat             54


<210>  87
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  87
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210>  88
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  88
ggtgggggcg gctctggtgg cggtggcagc ggcggaggtg gcagt                       45


<210>  89
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  89
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      120

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      180

cgcgacttcg cagcctatcg ctcc                                             204


<210>  90
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  90
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  91
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  91
cacgtgggtt ctggagaagg acgcggttcc ttgttgacgt gtggcgatgt agaggaaaat       60

ccgggtcca                                                               69


<210>  92
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  92
ccgagcggcc aggcgggcgc ggcggcatcg gagtccctgt ttgtgtcaaa tcacgcctac       60


<210>  93
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  93
gatattgttc ttactcaatc acccccaagc cttgcgatgt ctcttggtaa acgagcgaca       60

attagttgta gagcttctga aagcgtaact attcttgggt cacatcttat tcattggtat      120

caacaaaagc cgggacaacc gcctacactc ttgattcaac tcgcgagcaa tgttcaaacg      180

ggtgtccctg cacgcttttc tgggagcggt tcacgaacag attttactct cacgattgat      240

ccagtcgaag aagatgatgt cgctgtatat tattgtctcc aaagtaggac aataccaaga      300

acttttggtg gtggtacaaa attggaaatt aaa                                   333


<210>  94
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  94
gacatccaga tgacccagag ccctagctca ctgagcgcca gcgtgggcga cagggtgacc       60

attacctgct ccgccagcca ggacatcagc aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac acctccaacc tgcactccgg cgtgcccagc      180

aggttcagcg gaagcggcag cggcaccgat ttcaccctga ccatctccag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaggaagc tcccctggac tttcggccag      300

ggcaccaaac tggagatcaa gcgt                                             324


<210>  95
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  95
gacatcgtgc tgacccagag cccccccagc ctggccatgt ctctgggcaa gagagccacc       60

atcagctgcc gggccagcga gagcgtgacc atcctgggca gccacctgat ctactggtat      120

cagcagaagc ctggccagcc ccccaccctg ctgatccagc tggctagcaa tgtgcagacc      180

ggcgtgcccg ccagattcag cggcagcggc agcagaaccg acttcaccct gaccatcgac      240

cccgtggaag aggacgacgt ggccgtgtac tactgcctgc agagccggac catcccccgg      300

acctttggcg gaggaacaaa gctggaaatc aag                                   333


<210>  96
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  96
gacatcgtgc tgacccagag cccccccagc ctggccatgt ctctgggcaa gagagccacc       60

atcagctgcc gggccagcga gagcgtgacc atcctgggca gccacctgat ccactggtat      120

cagcagaagc ccggccagcc ccccaccctg ctgatccagc tcgccagcaa tgtgcagacc      180

ggcgtgcccg ccagattcag cggcagcggc agcagaaccg acttcaccct gaccatcgac      240

cccgtggaag aggacgacgt ggccgtgtac tactgcctgc agagccggac catcccccgg      300

acctttggcg gaggcaccaa actggaaatc aag                                   333


<210>  97
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  97
cagatccagc tggtgcagtc cggccccgag ctgaagaagc ccggcgagac cgtgaagatc       60

tcctgcaagg cctccggcta caccttcacc gactactcca tcaactgggt gaagcgggcc      120

cccggcaagg gcctgaagtg gatgggctgg atcaacaccg agacccggga gcccgcctac      180

gcctacgact tccggggccg gttcgccttc tccctggaga cctccgcctc caccgcctac      240

ctgcagatca acaacctgaa gtacgaggac accgccacct acttctgcgc cctggactac      300

tcctacgcca tggactactg gggccagggc acctccgtga ccgtgtcctc c               351


<210>  98
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  98
caggtgcagc tggtccagag cggcgccgaa gtgaagaagc ccggcagctc cgtgaaagtg       60

agctgcaagg ccagcggcgg caccttcagc aactactgga tgcactgggt gaggcaggcc      120

cccggacagg gcctggagtg gatgggcgcc acctacaggg gccacagcga cacctactac      180

aaccagaagt tcaagggccg ggtgaccatc accgccgaca agagcaccag caccgcctac      240

atggaactga gcagcctcag gagcgaggac accgctgtgt attactgcgc caggggcgcc      300

atctacaacg gctacgacgt gctggacaac tggggccagg gcacactagt gaccgtgtcc      360

agc                                                                    363


<210>  99
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  99
atgggatgga gctctatcat cctcttcttg gtagcaacag ctacaggtgt ccaccagatt       60

cagctggtgc agagcggccc tgagctgaag aaacccggcg agacagtgaa gatcagctgc      120

aaggcctccg gctacacctt ccggcactac agcatgaact gggtgaaaca ggcccctggc      180

aagggcctga agtggatggg ccggatcaac accgagagcg gcgtgcccat ctacgccgac      240

gacttcaagg gcagattcgc cttcagcgtg gaaaccagcg ccagcaccgc ctacctggtg      300

atcaacaacc tgaaggacga ggataccgcc agctacttct gcagcaacga ctacctgtac      360

agcctggact tctggggcca gggcaccgcc ctgaccgtgt ccagc                      405


<210>  100
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  100
cagattcagc tggtgcagag cggccctgag ctgaagaaac ccggcgagac agtgaagatc       60

agctgcaagg cctccggcta caccttcacc gactacagca tcaactgggt gaaaagagcc      120

cctggcaagg gcctgaagtg gatgggctgg atcaacaccg agacaagaga gcccgcctac      180

gcctacgact tccggggcag attcgccttc agcctggaaa ccagcgccag caccgcctac      240

ctgcagatca acaacctgaa gtacgaggac accgccacct acttttgcgc cctggactac      300

agctacgcca tggactactg gggccagggc accagcgtga ccgtgtccag c               351


<210>  101
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  101
cagtcagcgc ttacgcagcc ggcgtcggtg tcgggttccc cgggtcagtc gatcacgatc       60

agctgtagtg ggagcagctc caacatcggt aacaacgcag tgaactggta tcagcaactg      120

ccgggaaaag cgccgaaact gctgatttac tatgatgatt tgctgccaag tggagttagt      180

gaccgctttt ccggcagtaa atcgggtacc tcggcttttc tggctatttc gggtctccag      240

agcgaggatg aagctgatta ttattgcgcc gcatgggatg atagcttaaa tggcccagtt      300

tttggcggcg gtactaaact gaccgtgctg                                       330


<210>  102
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  102
caagtgcagc tggttgaatc cggtggcggt ctggtcaagc cgggcggctc tttgcgtctg       60

agctgtgccg cgtcgggttt taccttcagc tcttatggta tgcattgggt gcgtcaggcg      120

cctggcaaag gtctggagtg ggttgcgttc atccgctacg atgggtctaa caaatattat      180

gccgactcag taaaaggacg cttcactatt agccgcgaca atagcaaaaa taccctgtac      240

ctgcaaatga atagcctgcg cgccgaagat accgccgttt actattgcgc taaagatcgt      300

ggcctgggtg atggtacgta cttcgattac tggggtcagg gcaccaccgt taccgttagt      360

tca                                                                    363


<210>  103
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  103
gatattgtgc taactcagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt       60

ctttcctgca gggccagcca gagtattagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact      240

gaagattttg gagtgtattt ctgtcaacag agtaacacct ggccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  104
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  104
gacattgtga tgacacagtc tccatcctcc ctgagtgtgt cagcaggaga gaaggtcact       60

atgagctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctatatggcc      120

tggtatcagc agaaaccagg gcagcctcct aaactgttga tctacggggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaaccgattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga tcatagttat      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gg                         342


<210>  105
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  105
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc attgaagctg       60

tcctgcaagt cttccgggta caccttcacc agctactgga tgcactgggt gaggcagagg      120

cctggacatg gccttgagtg gatcggagag attgatcctt ctgacagtta taaagactac      180

aatcagaagt tcaaggacaa ggccacattg actgtggaca gatcctccaa cacagcctac      240

atgcacctca gcagcctgac atctgatgac tctgcggtct attattgtgc aagagcgatt      300

acgacgaccc cctttgactt ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  106
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  106
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccatc       60

acctgcacag tctctggttt ctcattaact aactatggtt tacactgggt tcgccagtct      120

ccaggaaagg gcctggagtg gctgggagtg atatggagtg gtggaagcac agactataat      180

gcagctttca tatccagact gagcatcagc aaggacaact ccaagagcca agttttcttt      240

aaaatgaaca gtctgcaggc tgatgacaca gccatatact actgtgccag aaaaggaggg      300

atctactatg ctaaccatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  107
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  107
aaacttgagt tgaagaccgg tgccggcttc accttaccga ccagttatca tcaacaatgc       60

tattacgtgg ccctggacga agcacaggtg aattcaatta cgtttacgtt tgataccggc      120

tctggcagcg gtacatttcg tgatcccgtg ggcacttacc gctattcggc gagttatatc      180

ttgctgaaac cttcccaagg tccgaaacag cagtactggg cggttggcac cattgtagac      240

caatcagcca aatgtacaat ctcggttcgc gatggtgtca gtacgtcgat gtctaagcag      300

tcacagacaa tggttatcga t                                                321


<210>  108
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  108
agcgttaccg tgagtacagg ccagggctgg tatgacatgg cacgtacagc catcatgacc       60

tcgcgcgcat gttactacgt cgcgtcagat gaatcgacgc cttcctcgct gcaaatgtat      120

gcaacctcca gcagcaaaga tgttaccctg accgcaaagg acaagtttaa acagaatttg      180

cgtacggaga gtgactcccc gcacatcatg ggaatctggg agttgggtca ggggcctcgt      240

cagaaggtat ggaacatgtg gtatacaact ttttcgtacg gctcagcaaa atgcagcttg      300

aaagtgtcgg caggtccgcg cgtgctggag gccggtccgc agcagctgca agtccagtct      360


<210>  109
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  109
ctcgagccca aatcttgtga caaaactcac acatgcccac cgtgcccgga tcccaaaggt       60

acc                                                                     63


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  This sequence may encompass 1-6 "Gly Ser" repeating units

<400>  110

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210>  111
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6xHis tag

<400>  111

His His His His His His 
1               5       


<210>  112
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  112
ctcgagccca aatcttgtga caaaactcac acatgcccac cgtgcccg                    48


<210>  113
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  113
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  114
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  114
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  115
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  115
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  116
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  116
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  117
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  117

Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
1               5                   10                  15      


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            20                  25                  30          


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        35                  40                  45              


Asp Ile Tyr 
    50      


<210>  118
<211>  49
<212>  PRT
<213>  Mus sp.

<400>  118

Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro 
1               5                   10                  15      


Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg 
            20                  25                  30          


Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Tyr 
    


<210>  119
<211>  51
<212>  PRT
<213>  Felis sp.

<400>  119

Pro Val Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Gln Ala 
1               5                   10                  15      


Pro Ile Thr Thr Ser Gln Arg Val Ser Leu Arg Pro Gly Thr Cys Gln 
            20                  25                  30          


Pro Ser Ala Gly Ser Thr Val Glu Ala Ser Gly Leu Asp Leu Ser Cys 
        35                  40                  45              


Asp Ile Tyr 
    50      


<210>  120
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  120

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  121
<211>  21
<212>  PRT
<213>  Mus sp.

<400>  121

Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      


Ile Ile Thr Leu Ile 
            20      


<210>  122
<211>  21
<212>  PRT
<213>  Rattus sp.

<400>  122

Ile Trp Ala Pro Leu Ala Gly Ile Cys Ala Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Ile 
            20      


<210>  123
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  123

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  124
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  124

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  125
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  125
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga cccta                      105


<210>  126
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  126
agggaccaga ggctgccccc cgatgcccac aagccccctg ggggaggcag tttccggacc       60

cccatccaag aggagcaggc cgacgcccac tccaccctgg ccaagatc                   108


<210>  127
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  128
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Ala Arg Leu Pro Val Lys Trp Met Ala Pro 
                805                 810                 815     


Glu Ser Leu Phe Glu Gly Ile Tyr Thr Ile Lys Ser Asp Val Trp Ser 
            820                 825                 830         


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Val Asn Pro Tyr 
        835                 840                 845             


Pro Gly Ile Pro Val Asp Ala Asn Phe Tyr Lys Leu Ile Gln Asn Gly 
    850                 855                 860                 


Phe Lys Met Asp Gln Pro Phe Tyr Ala Thr Glu Glu Ile Tyr Ile Ile 
865                 870                 875                 880 


Met Gln Ser Cys Trp Ala Phe Asp Ser Arg Lys Arg Pro Ser Phe Pro 
                885                 890                 895     


Asn Leu Thr Ser Phe Leu Gly Cys Gln Leu Ala Asp Ala Glu Glu Ala 
            900                 905                 910         


Met Tyr Gln Asn Val Asp Gly Arg Val Ser Glu Cys Pro His Thr Tyr 
        915                 920                 925             


Gln Asn Arg Arg Pro Phe Ser Arg Glu Met Asp Leu Gly Leu Leu Ser 
    930                 935                 940                 


Pro Gln Ala Gln Val Glu Asp Ser 
945                 950         


<210>  129
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  130
<211>  705
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Pro Gly Asn Glu Ser Leu Lys Ala Met Leu Phe Cys Leu 
625                 630                 635                 640 


Phe Lys Leu Ser Ser Cys Asn Gln Ser Asn Asp Gly Ser Val Ser His 
                645                 650                 655     


Gln Ser Gly Ser Pro Ala Ala Gln Glu Ser Cys Leu Gly Trp Ile Pro 
            660                 665                 670         


Ser Leu Leu Pro Ser Glu Phe Gln Leu Gly Trp Gly Gly Cys Ser His 
        675                 680                 685             


Leu His Ala Trp Pro Ser Ala Ser Val Ile Ile Thr Ala Ser Ser Cys 
    690                 695                 700                 


His 
705 


<210>  131
<211>  1200
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Leu Met 
            980                 985                 990         


Asp Glu Glu Asp Met Asp Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile 
        995                 1000                 1005             


Pro Gln  Gln Gly Phe Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro 
    1010                 1015                 1020             


Leu Leu  Ser Ser Leu Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala 
    1025                 1030                 1035             


Cys Ile  Asp Arg Asn Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp 
    1040                 1045                 1050             


Ser Phe  Leu Gln Arg Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr 
    1055                 1060                 1065             


Glu Asp  Ser Ile Asp Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile 
    1070                 1075                 1080             


Asn Gln  Ser Val Pro Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro 
    1085                 1090                 1095             


Val Tyr  His Asn Gln Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro 
    1100                 1105                 1110             


His Tyr  Gln Asp Pro His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr 
    1115                 1120                 1125             


Leu Asn  Thr Val Gln Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser 
    1130                 1135                 1140             


Pro Ala  His Trp Ala Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp 
    1145                 1150                 1155             


Asn Pro  Asp Tyr Gln Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro 
    1160                 1165                 1170             


Asn Gly  Ile Phe Lys Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu 
    1175                 1180                 1185             


Arg Val  Ala Pro Gln Ser Ser  Glu Phe Ile Gly Ala  
    1190                 1195                 1200 


<210>  132
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  132
gacattctaa tgacccaatc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

tacctgcaaa ggccaggcca gtctccaaag ctcctgatct acaaagtttc cgaccgattt      120

tacctgcaaa ggccaggcca gtctccaaag ctcctgatct acaaagtttc cgaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtag aggctgagga tctgggaatt tattactgct ttcaaggttc acatattcct      300

cccacgttcg gaggggggac caagctggaa atcaaacgtg cggcc                      345


<210>  133
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  133
caggtccagc tgcagcagtc tgggtctgag atggcgaggc ctggagcttc agtgaagctg       60

ccctgcaagg cttctggcga cacattcacc agttactgga tgcactgggt gaagcagagg      120

catggacatg gccctgagtg gatcggaaat atttatccag gtagtggtgg tactaactac      180

gctgagaagt tcaagaacaa ggtcactctg actgtagaca ggtcctcccg cacagtctac      240

atgcacctca gcaggctgac atctgaggac tctgcggtct attattgtac aagatcgggg      300

ggtccctact tctttgacta ctggggccaa ggcaccactc tcacagtctc ctcc            354


<210>  134
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  134

Gly Gly Gly Gly Ser 
1               5   


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  135

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  136
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  136

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  137
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  137

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  138
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  138

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  139
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  139

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  140
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  140

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  141
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  141

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  142
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  142

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  143
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  143

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser 
    50                  55  


<210>  144
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  144

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    50                  55                  60  


<210>  145
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  145

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser 
65  


<210>  146
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  146

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser 
65                  70  


<210>  147
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  147

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210>  148
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  148
aaggatctgc gatcgctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc       60

cgagaagttg gggggagggg tcggcaattg aacgggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagctgaag cttcgagggg ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg      300

ccgccatcca cgccggttga gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac      360

tgcgtccgcc gtctaggtaa gtttaaagct caggtcgaga ccgggccttt gtccggcgct      420

cccttggagc ctacctagac tcagccggct ctccacgctt tgcctgaccc tgcttgctca      480

actctacgtc tttgtttcgt tttctgttct gcgccgttac agatccaagc tgtgaccggc      540

gcctac                                                                 546


<210>  149
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  149

Ser Ser Val Thr Val Ser Thr Gly Gln Gly Trp Tyr Asp Met Ala Arg 
1               5                   10                  15      


Thr Ala Ile Met Thr Ser Arg Ala Cys Tyr Tyr Val Ala Ser Asp Glu 
            20                  25                  30          


Ser Thr Pro Ser Ser Leu Gln Met Tyr Ala Thr Ser Ser Ser Lys Asp 
        35                  40                  45              


Val Thr Leu Thr Ala Lys Asp Lys Phe Lys Gln Asn Leu Arg Thr Glu 
    50                  55                  60                  


Ser Asp Ser Pro His Ile Met Gly Ile Trp Glu Leu Gly Gln Gly Pro 
65                  70                  75                  80  


Arg Gln Lys Val Trp Asn Met Trp Tyr Thr Thr Phe Ser Tyr Gly Ser 
                85                  90                  95      


Ala Lys Cys Ser Leu Lys Val Ser Ala Gly Pro Arg Val Leu Glu Ala 
            100                 105                 110         


Gly Pro Gln Gln Leu Gln Val Gln 
        115                 120 


<210>  150
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  150

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  151

Ala Val Gly Thr Ile Val Asp Gln Ser Ala Lys 
1               5                   10      


<210>  152
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  Any amino acid

<400>  152

Tyr Xaa Xaa Gln 
1               


<210>  153
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  153

Tyr Arg His Gln 
1               


<210>  154
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  154

Lys Leu Glu Leu Lys Thr Gly Ala Gly Phe Thr Leu Pro Thr Ser Tyr 
1               5                   10                  15      


His Gln Gln Cys Tyr Tyr Val Ala Leu Asp Glu Ala Gln Val Asn Ser 
            20                  25                  30          


Ile Thr Phe Thr Phe Asp Thr Gly Ser Gly Ser Gly Thr Phe Arg Asp 
        35                  40                  45              


Pro Val Gly Thr Tyr Arg Tyr Ser Ala Ser Tyr Ile Leu Leu Lys Pro 
    50                  55                  60                  


Ser Gln Gly Pro Lys Gln Gln Tyr Trp Ala Val Gly Thr Ile Val Asp 
65                  70                  75                  80  


Gln Ser Ala Lys Cys Thr Ile Ser Val Arg Asp Gly Val Ser Thr Ser 
                85                  90                  95      


Met Ser Lys Gln Ser Gln Thr Met Val Ile Asp Ser 
            100                 105             


<210>  155
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  155
atgggatgga gctctatcat cctcttcttg gtagcaacag ctacaggtgt ccaccagatt       60

cagctggtgc agagcggccc tgagctgaag aaacccggcg agacagtgaa gatcagctgc      120

aaggcctccg gctacacctt caccgactac agcatcaact gggtgaaaag agcccctggc      180

aagggcctga agtggatggg ctggatcaac accgagacaa gagagcccgc ctacgcctac      240

gacttccggg gcagattcgc cttcagcctg gaaaccagcg ccagcaccgc ctacctgcag      300

atcaacaacc tgaagtacga ggacaccgcc acctactttt gcgccctgga ctacagctac      360

gccatggact actggggcca gggcaccagc gtgaccgtgt ccagc                      405


<210>  156
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  156
gacatcgtgc tgacccagag cccccccagc ctggccatgt ctctgggcaa gagagccacc       60

atcagctgcc gggccagcga gagcgtgacc atcctgggca gccacctgat ccactggtat      120

cagcagaagc ccggccagcc ccccaccctg ctgatccagc tcgccagcaa tgtgcagacc      180

ggcgtgcccg ccagattcag cggcagcggc agcagaaccg acttcaccct gaccatcgac      240

cccgtggaag aggacgacgt ggccgtgtac tactgcctgc agagccggac catcccccgg      300

acctttggcg gaggcaccaa actggaaatc aag                                   333


<210>  157
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  157
agcgttaccg tgagtacagg ccagggctgg tatgacatgg cacgtacagc catcatgacc       60

tcgcgcgcat gttactacgt cgcgtcagat gaatcgacgc cttcctcgct gcaaatgtat      120

gcaacctcca gcagcaaaga tgttaccctg accgcaaagg acaagtttaa acagaatttg      180

cgtacggaga gtgactcccc gcacatcatg ggaatctggg agttgggtca ggggcctcgt      240

cagaaggtat ggaacatgtg gtatacaact ttttcgtacg gctcagcaaa atgcagcttg      300

aaagtgtcgg caggtccgcg cgtgctggag gccggtccgc agcagctgca agtccagtct      360


<210>  158
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  158
aaacttgagt tgaagaccgg tgccggcttc accttaccga ccagttatca tcaacaatgc       60

tattacgtgg ccctggacga agcacaggtg aattcaatta cgtttacgtt tgataccggc      120

tctggcagcg gtacatttcg tgatcccgtg ggcacttacc gctattcggc gagttatatc      180

ttgctgaaac cttcccaagg tccgaaacag cagtactggg cggttggcac cattgtagac      240

caatcagcca aatgtacaat ctcggttcgc gatggtgtca gtacgtcgat gtctaagcag      300

tcacagacaa tggttatcga t                                                321


<210>  159
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  159
caagtgcagc tggttgaatc cggtggcggt ctggtcaagc cgggcggctc tttgcgtctg       60

agctgtgccg cgtcgggttt taccttcagc tcttatggta tgcattgggt gcgtcaggcg      120

cctggcaaag gtctggagtg ggttgcgttc atccgctacg atgggtctaa caaatattat      180

gccgactcag taaaaggacg cttcactatt agccgcgaca atagcaaaaa taccctgtac      240

ctgcaaatga atagcctgcg cgccgaagat accgccgttt actattgcgc taaagatcgt      300

ggcctgggtg atggtacgta cttcgattac tggggtcagg gcaccaccgt taccgttagt      360

tca                                                                    363


<210>  160
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  160
cagtcagcgc ttacgcagcc ggcgtcggtg tcgggttccc cgggtcagtc gatcacgatc       60

agctgtagtg ggagcagctc caacatcggt aacaacgcag tgaactggta tcagcaactg      120

ccgggaaaag cgccgaaact gctgatttac tatgatgatt tgctgccaag tggagttagt      180

gaccgctttt ccggcagtaa atcgggtacc tcggcttttc tggctatttc gggtctccag      240

agcgaggatg aagctgatta ttattgcgcc gcatgggatg atagcttaaa tggcccagtt      300

tttggcggcg gtactaaact gaccgtgctg                                       330


<210>  161
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  161
ggcggtggcg gttctggtgg cggtggctcc ggcggtggcg gttct                       45


<210>  162
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  162
caagtgcagc tggttgaatc cggtggcggt ctggtcaagc cgggcggctc tttgcgtctg       60

agctgtgccg cgtcgggttt taccttcagc tcttatggta tgcattgggt gcgtcaggcg      120

cctggcaaag gtctggagtg ggttgcgttc atccgctacg atgggtctaa caaatattat      180

gccgactcag taaaaggacg cttcactatt agccgcgaca atagcaaaaa taccctgtac      240

ctgcaaatga atagcctgcg cgccgaagat accgccgttt actattgcgc taaagatcgt      300

ggcctgggtg atggtacgta cttcgattac tggggtcagg gcaccaccgt taccgttagt      360

tcaggtgggg gcggctct                                                    378


<210>  163
<211>  326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  163
cagcgcttac gcagccggcg tcggtgtcgg gttccccggg tcagtcgatc acgatcagct       60

gtagtgggag cagctccaac atcggtaaca acgcagtgaa ctggtatcag caactgccgg      120

gaaaagcgcc gaaactgctg atttactatg atgatttgct gccaagtgga gttagtgacc      180

gcttttccgg cagtaaatcg ggtacctcgg cttttctggc tatttcgggt ctccagagcg      240

aggatgaagc tgattattat tgcgccgcat gggatgatag cttaaatggc ccagtttttg      300

gcggcggtac taaactgacc gtgctg                                           326


<210>  164
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  164
ctccgtgacg gtgtcgacgg gccaaggatg gtacgatatg gcacggaccg cgattatgac       60

atcgcgggcg tgctattacg tggccagcga tgagtcgacc ccttcctctc tgcaaatgta      120

tgccacctcc tcttcaaaag acgtgactct gactgcgaaa gacaaattta aacagaatct      180

gcgcaccgaa agcgatagcc cacatatcat gggcatctgg gaactgggcc agggcccccg      240

ccagaaagtg tggaacatgt ggtacaccac cttcagctat ggttcggcca aatgttccct      300

gaaggtatca gccggcccgc gcgttcttga ggcgggtccg cagcagctgc aggtacagag      360

c                                                                      361


<210>  165
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  165
aaactggaac tcaagacggg tgcgggattt accctcccta cgagctatca ccagcagtgc       60

tattacgtgg cgcttgacga agcgcaggtg aactctatta cctttacctt tgatacagga      120

tcaggcagcg gtacgttccg tgatccggta ggtacgtacc ggtatagtgc aagctatatc      180

cttctgaaac cttctcaggg tccgaaacag cagtactggg cggtgggaac gatcgtggac      240

cagtctgcca aatgtacaat ttcagttcgc gacggagtta gcacctccat gagcaagcag      300

tcccaaacca tggtgattga ctct                                             324


<210>  166
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  166
cagattcagc tggtgcagag cggccctgag ctgaagaaac ccggcgagac agtgaagatc       60

agctgcaagg cctccggcta caccttcacc gactacagca tcaactgggt gaaaagagcc      120

cctggcaagg gcctgaagtg gatgggctgg atcaacaccg agacaagaga gcccgcctac      180

gcctacgact tccggggcag attcgccttc agcctggaaa ccagcgccag caccgcctac      240

ctgcagatca acaacctgaa gtacgaggac accgccacct acttttgcgc cctggactac      300

agctacgcca tggactactg gggccagggc accagcgtga ccgtgtccag c               351


<210>  167
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  167
gacatcgtgc tgacccagag cccccccagc ctggccatgt ctctgggcaa gagagccacc       60

atcagctgcc gggccagcga gagcgtgacc atcctgggca gccacctgat ccactggtat      120

cagcagaagc ccggccagcc ccccaccctg ctgatccagc tcgccagcaa tgtgcagacc      180

ggcgtgcccg ccagattcag cggcagcggc agcagaaccg acttcaccct gaccatcgac      240

cccgtggaag aggacgacgt ggccgtgtac tactgcctgc agagccggac catcccccgg      300

acctttggcg gaggcaccaa actggaaatc aag                                   333


<210>  168
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  168
atggaatttg ggctgcgctg ggttttcctt gttgctattt taaaagatgt ccagtgt          57


<210>  169
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  169

Met Glu Phe Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Lys Asp 
1               5                   10                  15      


Val Gln Cys 
            


<210>  170
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  170
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc      600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacacaga agagcctctc cctgtctccg gagctgcaac tggaggagag ctgtgcggag      720

gcgcaggacg gggagctgga cgggctgtgg acgaccatca ccatcttcat cacactcttc      780

ctgttaagcg tgtgctacag tgccaccgtc accttcttca aggtgaagtg gatcttctcc      840

tcggtggtgg acctgaagca gaccatcatc cccgactaca ggaacatgat cggacagggg      900

gcc                                                                    903


<210>  171
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  171

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu 
225                 230                 235                 240 


Ala Gln Asp Gly Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe 
                245                 250                 255     


Ile Thr Leu Phe Leu Leu Ser Val Cys Tyr Ser Ala Thr Val Thr Phe 
            260                 265                 270         


Phe Lys Val Lys Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr 
        275                 280                 285             


Ile Ile Pro Asp Tyr Arg Asn Met Ile Gly Gln Gly Ala 
    290                 295                 300     


<210>  172
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  172

Glu Leu Arg Glu Ala Thr Ser 
1               5           


<210>  173
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  173

Glu Leu Arg Glu Ala Thr 
1               5       


<210>  174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Any amino acid

<400>  174

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


