                         SEQUENCE LISTING

<110>  Yale University
       MANDL, HANNA
       QUIJANO, ELIAS
       SALTZMAN, W.  MARK
       GLAZER, PETER
 
<120>  NANOPARTICLES FOR SELECTIVE TISSUE OR CELLULAR UPTAKE

<130>  YU 7724 PCT

<150>  62/897,655
<151>  2019-09-09

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  1
gaaagaaaga ga                                                           12


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  2
tgccctgaaa gaaagaga                                                     18


<210>  3
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  3
ggagaaa                                                                  7


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  4
agaatggtgc aaagagg                                                      17


<210>  5
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  5
aaaaggg                                                                  7


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  6
acatgattag caaaaggg                                                     18


<210>  7
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  7
ctttctttct ct                                                           12


<210>  8
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  8
tctctttctt tc                                                           12


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  9
tctctttctt tcagggca                                                     18


<210>  10
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  10
tttccc                                                                   6


<210>  11
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  11
ccctttt                                                                  7


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  12
cccttttgct aatcatgt                                                     18


<210>  13
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  13
tttctcc                                                                  7


<210>  14
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  14
cctcttt                                                                  7


<210>  15
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  15
cctctttgca ccattct                                                      17


<210>  16
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = Pseudoisocytosine

<400>  16
ntttntttnt nt                                                           12


<210>  17
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  n = Pseudoisocytosine

<400>  17
ttttnnn                                                                  7


<210>  18
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n = Pseudoisocytosine

<400>  18
tttntnn                                                                  7


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Linked to lys-lys-lys

<400>  19
ntttntttnt nttctctttc tttcagggca                                        30


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  20
ttttnnnccc ttttgctaat catgt                                             25


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Linked to lys-lys-lys

<400>  21
tttntnncct ctttgcacca ttct                                              24


<210>  22
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = Pseudoisocytosine

<400>  22
tnttttnttn                                                              10


<210>  23
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  23
cttcttttct                                                              10


<210>  24
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = Pseudoisocytosine

<400>  24
ttnttntttn                                                              10


<210>  25
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  25
ctttcttctt                                                              10


<210>  26
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = Pseudoisocytosine

<400>  26
nnntnnttnt                                                              10


<210>  27
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  27
tcttcctccc                                                              10


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Linked to lys-lys-lys

<400>  28
ttnttntttn ctttcttctt                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Linked to lys-lys-lys

<400>  29
nnntnnttnt tcttcctccc                                                   20


<210>  30
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  30
cctcttc                                                                  7


<210>  31
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  31
cttctcc                                                                  7


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  32
cttctccaaa ggagt                                                        15


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  33
cttctccaca ggagtcag                                                     18


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  34
cttctccaca ggagtcaggt gc                                                22


<210>  35
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  35
ttcctct                                                                  7


<210>  36
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  36
tctcctt                                                                  7


<210>  37
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  37
tctccttaaa cctgt                                                        15


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  38
tctccttaaa cctgtctt                                                     18


<210>  39
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  39
tctcttct                                                                 8


<210>  40
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  40
tcttctct                                                                 8


<210>  41
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  41
tcttctctgt ctccac                                                       16


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Linked to lys-lys-lys

<400>  42
tnttttnttn cttcttttct                                                   20


<210>  43
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<400>  43
nntnttn                                                                  7


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Linked to lys-lys-lys

<400>  44
nntnttnctt ctccaaagga gt                                                22


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Linked to lys-lys-lys

<400>  45
ttnntnttct ccttaaacct gt                                                22


<210>  46
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  46
ttnntnttct ccttaaacct gtctt                                             25


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Linked to lys-lys-lys

<400>  47
tntnttnttc ttctctgtct ccac                                              24


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  48
nntnttnctt ctccacagga gtcag                                             25


<210>  49
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Linked to lys-lys-lys

<400>  49
nntnttnctt ctccacagga gtcaggtgc                                         29


<210>  50
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  50
cttacccata gaggaaa                                                      17


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  51
aaagaataac agtgataatt tctgggttaa ggcaatagca atatctctgc atataaatat       60


<210>  52
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  52
gttcagcgtg tccggcgagg gcgaggtgag tctatgggac ccttgatgtt t                51


<210>  53
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  53
aaacatcaag ggtcccatag actcacctcg ccctcgccgg acacgctgaa c                51


<210>  54
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  54
cttgccccac agggcagtaa cggcagattt ttcttccggc gttaaatgca ccatggtgtc       60

tgtttgaggt                                                              70


<210>  55
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  55
acagacacca tggtgcacct gactcctgag gagaagtctg ccgttactgc c                51


<210>  56
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (62)..(63)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (63)..(64)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (64)..(65)
<223>  Optional phosphorothioate internucleoside linkage

<400>  56
ttgccccaca gggcagtaac ggcagacttc tcctcaggag tcaggtgcac catggtgtct       60

gtttg                                                                   65


<210>  57
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  57
tttcctct                                                                 8


<210>  58
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  58
tttcctctat gggtaag                                                      17


<210>  59
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  59
agaggaaa                                                                 8


<210>  60
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Linked to lys-lys-lys

<400>  60
tntnttnttc ttctctgtct ccacat                                            26


<210>  61
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  61
agaagagg                                                                 8


<210>  62
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  62
atgccaacta gaagagg                                                      17


<210>  63
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  63
cctcttct                                                                 8


<210>  64
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  64
cctcttctag ttggcat                                                      17


<210>  65
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  65
ctttccctt                                                                9


<210>  66
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  66
ctttcccttg tatctttt                                                     18


<210>  67
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  67
aagggaaag                                                                9


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  68
aaaagataca agggaaag                                                     18


<210>  69
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  69
gaaggagaaa                                                              10


<210>  70
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  70
aaaagga                                                                  7


<210>  71
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  71
agaaaaaagg                                                              10


<210>  72
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  72
agaaaaa                                                                  7


<210>  73
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  73
agagaaaga                                                                9


<210>  74
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  74
aaagaaa                                                                  7


<210>  75
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  75
tctccttt                                                                 8


<210>  76
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  76
ttccctttc                                                                9


<210>  77
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n = Pseudoisocytosine

<400>  77
tntnnttt                                                                 8


<210>  78
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  78
tcttctcc                                                                 8


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  79
tcttctctgt ctccacat                                                     18


<210>  80
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  80
tntttttttt ttctgtaatt tttaa                                             25


<210>  81
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Linked to lys-lys-lys

<400>  81
tntntttntt ctttctctgc aaactt                                            26


<210>  82
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  82
tttntttttt ctttaagaac gagca                                             25


<210>  83
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (58)..(59)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (59)..(60)
<223>  Optional phosphorothioate internucleoside linkage

<400>  83
aagtttgcag agaaagataa tatagtcctt ggagaaggag gaatcaccct gagtggaggt       60


<210>  84
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n = Pseudoisocytosine

<400>  84
tnttntnn                                                                 8


<210>  85
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = Pseudoisocytosine

<400>  85
ttnnntttn                                                                9


<210>  86
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  86
tntnnttttt tcctctatgg gtaag                                             25


<210>  87
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Linked to lys-lys-lys

<400>  87
tnttntnncc tcttctagtt ggcat                                             25


<210>  88
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Linked to lys-lys-lys

<400>  88
ttnnntttnc tttcccttgt atctttt                                           27


<210>  89
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  89
ttctgtatct atattcatca taggaaacac caaagataat gttctcctta atggtgccag       60

g                                                                       61


<210>  90
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  90
cttcctcttt                                                              10


<210>  91
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  91
tttctccttc                                                              10


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  92
tttctccttc agtgttca                                                     18


<210>  93
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  93
ttttcct                                                                  7


<210>  94
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  94
tcctttt                                                                  7


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  95
tccttttgct cacctgtggt                                                   20


<210>  96
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  96
tcttttttcc                                                              10


<210>  97
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  97
ccttttttct                                                              10


<210>  98
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  98
ccttttttct ggctaagt                                                     18


<210>  99
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<400>  99
nttnntnttt                                                              10


<210>  100
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n = Pseudoisocytosine

<400>  100
ttttnnt                                                                  7


<210>  101
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n = Pseudoisocytosine

<400>  101
tnttttttnn                                                              10


<210>  102
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Linked to lys-lys-lys

<400>  102
nttnntnttt tttctccttc agtgttca                                          28


<210>  103
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Linked to lys-lys-lys

<400>  103
ttttnnttcc ttttgctcac ctgtggt                                           27


<210>  104
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide Nucleic Acid


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Linked to lys-lys-lys

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Linked by three 8-amino-2, 6, 10-trioxaoctanoic acid, three 
       8-amino-3,6-dioxaoctanoic acid, or three 6-aminohexanoic acid 
       molecules

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Linked to lys-lys-lys

<400>  104
tnttttttnn ccttttttct ggctaagt                                          28


<210>  105
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (55)..(56)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (56)..(57)
<223>  Optional phosphorothioate internucleoside linkage

<220>
<221>  misc_feature
<222>  (57)..(58)
<223>  Optional phosphorothioate internucleoside linkage

<400>  105
tgggattcaa taaccttgca gacagtggag gaaggccttt ggcgtgatac cacaggtg         58


<210>  106
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  106
tcttttt                                                                  7


<210>  107
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  107
tttttct                                                                  7


<210>  108
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  108
tttttctgta atttttaa                                                     18


<210>  109
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  109
tctctttct                                                                9


<210>  110
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  110
tctttctct                                                                9


<210>  111
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  111
tctttctctg caaactt                                                      17


<210>  112
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  112
tttcttt                                                                  7


<210>  113
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer

<400>  113
tttctttaag aacgagca                                                     18


<210>  114
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<400>  114
tnttttt                                                                  7


<210>  115
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n = Pseudoisocytosine

<400>  115
tntntttnt                                                                9


<210>  116
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Primer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = Pseudoisocytosine

<400>  116
tttnttt                                                                  7


