                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Rajadas, Jayakumar
       Potula, Hari
       Ahmed, Mohammed
       Pothinen, Venkata
 
<120>  Therapeutic Agents and Methods for Treatment of Lyme Disease and 
       Lyme Disease-Related Disorders

<130>  STAN-1731WO

<140>  PCT/US2020/049965
<141>  2020-09-09

<150>  US 62/899134
<151>  2019-09-11

<150>  US 62/923519
<151>  2019-10-19

<150>  US 62/983467
<151>  2020-02-28

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Flab-1F primer sequence

<400>  1
gcagctaaat gttgcaaatc ttttc                                             25


<210>  2
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Flab-1R primer sequence

<400>  2
gcaggtgctg gctgttga                                                     18


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TAMRA probe primer sequence

<400>  3
aaactgctca ggctgcaccg gttc                                              24


<210>  4
<211>  1157
<212>  DNA
<213>  Homo sapiens

<400>  4
cctgcagagg atcaagacag cacgtggacc tcgcacagcc tctcccacag gtaccatgaa       60

ggtctccgcg gcagccctcg ctgtcatcct cattgctact gccctctgcg ctcctgcatc      120

tgcctcccca tattcctcgg acaccacacc ctgctgcttt gcctacattg cccgcccact      180

gccccgtgcc cacatcaagg agtatttcta caccagtggc aagtgctcca acccagcagt      240

cgtctttgtc acccgaaaga accgccaagt gtgtgccaac ccagagaaga aatgggttcg      300

ggagtacatc aactctttgg agatgagcta ggatggagag tccttgaacc tgaacttaca      360

caaatttgcc tgtttctgct tgctcttgtc ctagcttggg aggcttcccc tcactatcct      420

accccacccg ctccttgaag ggcccagatt ctaccacaca gcagcagtta caaaaacctt      480

ccccaggctg gacgtggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg      540

gtggatcact tgaggtcagg agttcgagac cagcctggcc aacatgatga aaccccatct      600

ctactaaaaa tacaaaaaat tagccgggcg tggtagcggg cgcctgtagt cccagctact      660

cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagccgag      720

atcgcgccac tgcactccag cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa      780

cgggaggcta aggcaggaaa attgtttgaa cccaggaggt ggaggctgca gtgagctgag      840

attgtgccac ttcactccag cctgggtgac aaagtgagac tccgtcacaa caacaacaac      900

aaaaagcttc cccaactaaa gcctagaaga gcttctgagg cgctgctttg tcaaaaggaa      960

gtctctaggt tctgagctct ggctttgcct tggctttgcc agggctctgt gaccaggaag     1020

gaagtcagca tgcctctaga ggcaaggagg ggaggaacac tgcactctta agcttccgcc     1080

gtctcaaccc ctcacaggag cttactggca aacatgaaaa atcggcttac cattaaagtt     1140

ctcaatgcaa ccataaa                                                    1157


<210>  5
<211>  1157
<212>  DNA
<213>  Homo sapiens

<400>  5
cctgcagagg atcaagacag cacgtggacc tcgcacagcc tctcccacag gtaccatgaa       60

ggtctccgcg gcagccctcg ctgtcatcct cattgctact gccctctgcg ctcctgcatc      120

tgcctcccca tattcctcgg acaccacacc ctgctgcttt gcctacattg cccgcccact      180

gccccgtgcc cacatcaagg agtatttcta caccagtggc aagtgctcca acccagcagt      240

cgtctttgtc acccgaaaga accgccaagt gtgtgccaac ccagagaaga aatgggttcg      300

ggagtacatc aactctttgg agatgagcta ggatggagag tccttgaacc tgaacttaca      360

caaatttgcc tgtttctgct tgctcttgtc ctagcttggg aggcttcccc tcactatcct      420

accccacccg ctccttgaag ggcccagatt ctaccacaca gcagcagtta caaaaacctt      480

ccccaggctg gacgtggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg      540

gtggatcact tgaggtcagg agttcgagac cagcctggcc aacatgatga aaccccatct      600

ctactaaaaa tacaaaaaat tagccgggcg tggtagcggg cgcctgtagt cccagctact      660

cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagccgag      720

atcgcgccac tgcactccag cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa      780

cgggaggcta aggcaggaaa attgtttgaa cccaggaggt ggaggctgca gtgagctgag      840

attgtgccac ttcactccag cctgggtgac aaagtgagac tccgtcacaa caacaacaac      900

aaaaagcttc cccaactaaa gcctagaaga gcttctgagg cgctgctttg tcaaaaggaa      960

gtctctaggt tctgagctct ggctttgcct tggctttgcc agggctctgt gaccaggaag     1020

gaagtcagca tgcctctaga ggcaaggagg ggaggaacac tgcactctta agcttccgcc     1080

gtctcaaccc ctcacaggag cttactggca aacatgaaaa atcggcttac cattaaagtt     1140

ctcaatgcaa ccataaa                                                    1157


<210>  6
<211>  1217
<212>  DNA
<213>  Homo sapiens

<400>  6
cctgcagagg atcaagacag cacgtggacc tcgcacagcc tctcccacag gtaccatgaa       60

ggtctccgcg gcagccctcg ctgtcatcct cattgctact gccctctgcg ctcctgcatc      120

tgcctcccca tattcctcgg acaccacacc ctgctgcttt gcctacattg cccgcccact      180

gccccgtgcc cacatcaagg agtatttcta caccagtggc aagtgctcca acccagcagt      240

cgtctttgtc acccgaaaga accgccaagt gtgtgccaac ccagagaaga aatgggttcg      300

ggagtacatc aactctttgg agatgagcta ggatggagag tccttgaacc tgaacttaca      360

caaatttgcc tgtttctgct tgctcttgtc ctagcttggg aggcttcccc tcactatcct      420

accccacccg ctccttgaag ggcccagatt ctaccacaca gcagcagtta caaaaacctt      480

ccccaggctg gacgtggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg      540

gtggatcact tgaggtcagg agttcgagac cagcctggcc aacatgatga aaccccatct      600

ctactaaaaa tacaaaaaat tagccgggcg tggtagcggg cgcctgtagt cccagctact      660

cgggaggctg aggcaggaga atggcgtgaa cccgggaggc ggagcttgca gtgagccgag      720

atcgcgccac tgcactccag cctgggcgac agagcgagac tccgtctcaa aaaaaaaaaa      780

aaaaaaaaaa atacaaaaat tagccgggcg tggtggccca cgcctgtaat cccagctact      840

cgggaggcta aggcaggaaa attgtttgaa cccaggaggt ggaggctgca gtgagctgag      900

attgtgccac ttcactccag cctgggtgac aaagtgagac tccgtcacaa caacaacaac      960

aaaaagcttc cccaactaaa gcctagaaga gcttctgagg cgctgctttg tcaaaaggaa     1020

gtctctaggt tctgagctct ggctttgcct tggctttgcc agggctctgt gaccaggaag     1080

gaagtcagca tgcctctaga ggcaaggagg ggaggaacac tgcactctta agcttccgcc     1140

gtctcaaccc ctcacaggag cttactggca aacatgaaaa atcggcttac cattaaagtt     1200

ctcaatgcaa ccataaa                                                    1217


<210>  7
<211>  1678
<212>  DNA
<213>  Homo sapiens

<400>  7
agcagacgct ccctcagcaa ggacagcaga ggaccagcta agagggagag aagcaactac       60

agaccccccc tgaaaacaac cctcagacgc cacatcccct gacaagctgc caggcaggtt      120

ctcttcctct cacatactga cccacggctc caccctctct cccctggaaa ggacaccatg      180

agcactgaaa gcatgatccg ggacgtggag ctggccgagg aggcgctccc caagaagaca      240

ggggggcccc agggctccag gcggtgcttg ttcctcagcc tcttctcctt cctgatcgtg      300

gcaggcgcca ccacgctctt ctgcctgctg cactttggag tgatcggccc ccagagggaa      360

gagttcccca gggacctctc tctaatcagc cctctggccc aggcagtcag atcatcttct      420

cgaaccccga gtgacaagcc tgtagcccat gttgtagcaa accctcaagc tgaggggcag      480

ctccagtggc tgaaccgccg ggccaatgcc ctcctggcca atggcgtgga gctgagagat      540

aaccagctgg tggtgccatc agagggcctg tacctcatct actcccaggt cctcttcaag      600

ggccaaggct gcccctccac ccatgtgctc ctcacccaca ccatcagccg catcgccgtc      660

tcctaccaga ccaaggtcaa cctcctctct gccatcaaga gcccctgcca gagggagacc      720

ccagaggggg ctgaggccaa gccctggtat gagcccatct atctgggagg ggtcttccag      780

ctggagaagg gtgaccgact cagcgctgag atcaatcggc ccgactatct cgactttgcc      840

gagtctgggc aggtctactt tgggatcatt gccctgtgag gaggacgaac atccaacctt      900

cccaaacgcc tcccctgccc caatcccttt attaccccct ccttcagaca ccctcaacct      960

cttctggctc aaaaagagaa ttgggggctt agggtcggaa cccaagctta gaactttaag     1020

caacaagacc accacttcga aacctgggat tcaggaatgt gtggcctgca cagtgaagtg     1080

ctggcaacca ctaagaattc aaactggggc ctccagaact cactggggcc tacagctttg     1140

atccctgaca tctggaatct ggagaccagg gagcctttgg ttctggccag aatgctgcag     1200

gacttgagaa gacctcacct agaaattgac acaagtggac cttaggcctt cctctctcca     1260

gatgtttcca gacttccttg agacacggag cccagccctc cccatggagc cagctccctc     1320

tatttatgtt tgcacttgtg attatttatt atttatttat tatttattta tttacagatg     1380

aatgtattta tttgggagac cggggtatcc tgggggaccc aatgtaggag ctgccttggc     1440

tcagacatgt tttccgtgaa aacggagctg aacaataggc tgttcccatg tagccccctg     1500

gcctctgtgc cttcttttga ttatgttttt taaaatattt atctgattaa gttgtctaaa     1560

caatgctgat ttggtgacca actgtcactc attgctgagc ctctgctccc caggggagtt     1620

gtgtctgtaa tcgccctact attcagtggc gagaaataaa gtttgcttag aaaagaaa       1678


<210>  8
<211>  1211
<212>  DNA
<213>  Homo sapiens

<400>  8
acattgttct gatcatctga agatcagcta ttagaagaga aagatcagtt aagtcctttg       60

gacctgatca gcttgataca agaactactg atttcaactt ctttggctta attctctcgg      120

aaacgatgaa atatacaagt tatatcttgg cttttcagct ctgcatcgtt ttgggttctc      180

ttggctgtta ctgccaggac ccatatgtaa aagaagcaga aaaccttaag aaatatttta      240

atgcaggtca ttcagatgta gcggataatg gaactctttt cttaggcatt ttgaagaatt      300

ggaaagagga gagtgacaga aaaataatgc agagccaaat tgtctccttt tacttcaaac      360

tttttaaaaa ctttaaagat gaccagagca tccaaaagag tgtggagacc atcaaggaag      420

acatgaatgt caagtttttc aatagcaaca aaaagaaacg agatgacttc gaaaagctga      480

ctaattattc ggtaactgac ttgaatgtcc aacgcaaagc aatacatgaa ctcatccaag      540

tgatggctga actgtcgcca gcagctaaaa cagggaagcg aaaaaggagt cagatgctgt      600

ttcgaggtcg aagagcatcc cagtaatggt tgtcctgcct gcaatatttg aattttaaat      660

ctaaatctat ttattaatat ttaacattat ttatatgggg aatatatttt tagactcatc      720

aatcaaataa gtatttataa tagcaacttt tgtgtaatga aaatgaatat ctattaatat      780

atgtattatt tataattcct atatcctgtg actgtctcac ttaatccttt gttttctgac      840

taattaggca aggctatgtg attacaaggc tttatctcag gggccaacta ggcagccaac      900

ctaagcaaga tcccatgggt tgtgtgttta tttcacttga tgatacaatg aacacttata      960

agtgaagtga tactatccag ttactgccgg tttgaaaata tgcctgcaat ctgagccagt     1020

gctttaatgg catgtcagac agaacttgaa tgtgtcaggt gaccctgatg aaaacatagc     1080

atctcaggag atttcatgcc tggtgcttcc aaatattgtt gacaactgtg actgtaccca     1140

aatggaaagt aactcatttg ttaaaattat caatatctaa tatatatgaa taaagtgtaa     1200

gttcacaact a                                                          1211


<210>  9
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  9
acacatcagg ggcttgctct tgcaaaacca aaccacaaga cagacttgca aaagaaggca       60

tgcacagctc agcactgctc tgttgcctgg tcctcctgac tggggtgagg gccagcccag      120

gccagggcac ccagtctgag aacagctgca cccacttccc aggcaacctg cctaacatgc      180

ttcgagatct ccgagatgcc ttcagcagag tgaagacttt ctttcaaatg aaggatcagc      240

tggacaactt gttgttaaag gagtccttgc tggaggactt taagggttac ctgggttgcc      300

aagccttgtc tgagatgatc cagttttacc tggaggaggt gatgccccaa gctgagaacc      360

aagacccaga catcaaggcg catgtgaact ccctggggga gaacctgaag accctcaggc      420

tgaggctacg gcgctgtcat cgatttcttc cctgtgaaaa caagagcaag gccgtggagc      480

aggtgaagaa tgcctttaat aagctccaag agaaaggcat ctacaaagcc atgagtgagt      540

ttgacatctt catcaactac atagaagcct acatgacaat gaagatacga aactgagaca      600

tcagggtggc gactctatag actctaggac ataaattaga ggtctccaaa atcggatctg      660

gggctctggg atagctgacc cagccccttg agaaacctta ttgtacctct cttatagaat      720

atttattacc tctgatacct caacccccat ttctatttat ttactgagct tctctgtgaa      780

cgatttagaa agaagcccaa tattataatt tttttcaata tttattattt tcacctgttt      840

ttaagctgtt tccatagggt gacacactat ggtatttgag tgttttaaga taaattataa      900

gttacataag ggaggaaaaa aaatgttctt tggggagcca acagaagctt ccattccaag      960

cctgaccacg ctttctagct gttgagctgt tttccctgac ctccctctaa tttatcttgt     1020

ctctgggctt ggggcttcct aactgctaca aatactctta ggaagagaaa ccagggagcc     1080

cctttgatga ttaattcacc ttccagtgtc tcggagggat tcccctaacc tcattcccca     1140

accacttcat tcttgaaagc tgtggccagc ttgttattta taacaaccta aatttggttc     1200

taggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggtg     1260

gatcacttga ggtcaggagt tcctaaccag cctggtcaac atggtgaaac cccgtctcta     1320

ctaaaaatac aaaaattagc cgggcatggt ggcgcgcacc tgtaatccca gctacttggg     1380

aggctgaggc aagagaattg cttgaaccca ggagatggaa gttgcagtga gctgatatca     1440

tgcccctgta ctccagcctg ggtgacagag caagactctg tctcaaaaaa taaaaataaa     1500

aataaatttg gttctaatag aactcagttt taactagaat ttattcaatt cctctgggaa     1560

tgttacattg tttgtctgtc ttcatagcag attttaattt tgaataaata aatgtatctt     1620

attcacatca                                                            1630


<210>  10
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Arg Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Gln Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Lys Asn Gly Lys Ser Asn 
            100                 105         


<210>  12
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  13
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  14
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  15
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  15

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  16
<211>  1507
<212>  DNA
<213>  Homo sapiens

<400>  16
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaagaa     1500

aaaaaaa                                                               1507


<210>  17
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  18
<211>  570
<212>  PRT
<213>  Borrelia burgdorferi

<400>  18

Met Gln Ile Gly Lys His Leu Phe Tyr Asp Arg Glu Ala Asn Val Phe 
1               5                   10                  15      


Leu Ser Arg Leu Glu Lys Ile Asn Ala Ser Arg Gly Glu Ile Leu Asp 
            20                  25                  30          


Ser Asn Ser Asn Val Leu Ala Asn Asn Leu Thr Met Phe Ile Leu Lys 
        35                  40                  45              


Ile Ser Leu Gln Gln Tyr Tyr Asn Met Pro Ala Ala Thr Arg Ile Glu 
    50                  55                  60                  


Met Ile Asp Phe Leu Ser Ser Thr Leu Asp Ile Asp Lys Ser Ile Ile 
65                  70                  75                  80  


Leu Ser Lys Leu Gln Glu Pro Gly Gly Tyr Leu Lys Asp Val Glu Ile 
                85                  90                  95      


Ile Glu Leu Thr Pro Lys Met Leu Phe Lys Ile Ser Glu Lys Lys Phe 
            100                 105                 110         


Tyr Tyr Pro Ala Leu Leu Trp Thr Tyr Ser Phe Lys Arg Asn Tyr Leu 
        115                 120                 125             


Val Asp Asp Ser Tyr Ser His Ser Ile Gly Tyr Val Gly Gln Ile Asn 
    130                 135                 140                 


Gln Arg Glu Leu Arg Thr Phe Tyr Asn Val Ser Gly Tyr Asp Asn Thr 
145                 150                 155                 160 


Ser Thr Ile Gly Lys Leu Gly Val Glu Gln Val Tyr Asp Asn Tyr Ile 
                165                 170                 175     


Arg Gly Gln Glu Gly Leu Ile Lys Tyr Lys Val Asp Ser Lys Glu Arg 
            180                 185                 190         


Arg Ile Asp Asp Gly Ser Ile Ile Lys Asn Met Val Pro Gly Asn Asp 
        195                 200                 205             


Val Val Leu Asn Ile Asn Lys Asp Ile Gln Asp Leu Ala Lys Asn Ala 
    210                 215                 220                 


Leu Gly Lys Arg Tyr Gly Ser Val Val Val Leu Lys Pro Ser Thr Gly 
225                 230                 235                 240 


Ala Val Leu Ala Leu His Asn Tyr Pro Tyr Tyr Ser Met Lys Asp Val 
                245                 250                 255     


Tyr Asn Lys Asp Asn Lys Glu Asp Tyr Ser Phe Leu Asn Lys Ala Ile 
            260                 265                 270         


Gln Ser Val Tyr Pro Pro Ala Ser Ile Phe Lys Leu Val Val Ala Ala 
        275                 280                 285             


Ala Ile Leu Glu Glu Arg Val Ile Asp Lys Asp Arg Lys Ile Tyr Cys 
    290                 295                 300                 


Pro Gly Tyr Phe Lys Val Gly Asn Arg Ile Phe His Cys Trp Lys Pro 
305                 310                 315                 320 


Gly Gly His Gly Tyr Val Asn Leu Glu Glu Ala Ile Ala His Ser Ser 
                325                 330                 335     


Asn Val Tyr Phe Tyr Thr Leu Gly Leu Lys Tyr Leu Gly Val Asp Arg 
            340                 345                 350         


Ile Arg Lys Tyr Ala Lys Glu Phe Gly Phe Gly Glu Lys Thr Gly Ile 
        355                 360                 365             


Asp Leu Pro Asn Glu Val Ala Gly Leu Leu Pro Ser Pro Glu Trp Lys 
    370                 375                 380                 


Glu Lys Thr Phe Asn Gln Pro Trp Val Gly Gly Asp Thr Val Asn Phe 
385                 390                 395                 400 


Ser Ile Gly Gln Gly Phe Leu Asn Ala Thr Pro Met Gln Ile Val Asn 
                405                 410                 415     


Met Val Ala Met Ile Ala Asn Glu Gly Val Val Tyr Lys Pro Arg Ile 
            420                 425                 430         


Val Asn Lys Ile Leu Lys Gly Gly Thr Asn Lys Val Val Leu Glu Asn 
        435                 440                 445             


Lys Pro Glu Ile Leu Arg Lys Thr Asn Leu Ile Ser Lys Asn Thr Phe 
    450                 455                 460                 


Lys Leu Leu Lys Lys Tyr Met Arg Ser Val Ile Thr Tyr Gly Thr Ala 
465                 470                 475                 480 


Arg Tyr Ala Val Leu Thr Lys Ala Val Glu Val Gly Gly Lys Thr Gly 
                485                 490                 495     


Thr Gly Gln Thr Gly Ile Asp Gly Phe Glu Asn Ser Ser Phe Ile Gly 
            500                 505                 510         


Leu Ala Pro Tyr Asn Gly Ser Ala Asp Asn Gln Ile Ile Val Phe Ser 
        515                 520                 525             


Leu Val Glu Ala Lys Ser Asn Val Asp Trp Trp Pro Ala Lys Ser Thr 
    530                 535                 540                 


Asp Leu Ile Met Gln Gly Ile Phe Ala Asn Gln Ser Tyr Glu Asp Ile 
545                 550                 555                 560 


Leu Lys Gly Tyr Arg Pro Trp Tyr Ile Arg 
                565                 570 


<210>  19
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val His Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Asn Phe Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Leu Thr Val Thr Thr Asp Thr Ser Thr Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Pro Asp Tyr Glu Ser Ser Asp Ser Pro Trp 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Pro Leu Pro Pro Lys Thr 
            260                 265                 270         


Gln Gly His 
        275 


<210>  20
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  21
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  22
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  23
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  24
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Ala Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Leu 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asn Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  25
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


