                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       The Brigham & Women's Hospital, Inc.
       President and Fellows of Harvard College
 
<120>  Compositions, Methods, and Uses for Free Fatty Acid Screening of 
       Cells at Scale

<130>  52199-550001WO

<150>  US 62/898,514
<151>  2019-09-10

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  17701
<212>  DNA
<213>  Homo sapiens

<400>  1
atcacttctc cctgggctcc caggccctcc tgcagcagcc cccgcctggg ccatgtcttc       60

ctcagatgaa gagacgctca gtgagcggtc atgtcggagt gagcggtctt gtcggagtga      120

gcgatcttac aggagcgagc ggtcggggag cctgtctccc tgtcccccag gggacacctt      180

gccctggaac ctgccactgc atgagcagaa aaagcggaaa agccaggatt cggtgctgga      240

ccctgcagag cgtgctgtgg tcagagtcgc tgatgaacgg gaccgggttc agaagaaaac      300

gttcaccaag tgggtcaaca agcacttaat gaaggtccgc aagcacatca atgatcttta      360

tgaagatctg cgggatggcc ataacctgat ctctctgttg gaggtcctct caggcatcaa      420

actgccccgg gagaagggca ggatgcgttt tcataggctg cagaatgtgc agattgccct      480

ggacttccta aagcagcgac aggtgaaact agtgaatatt cgcaatgatg acatcacaga      540

tggcaacccc aagttgaccc tgggtctgat ctggaccatt attttgcatt tccagatctc      600

tgacatctac attagtggag aatcagggga tatgtcagcc aaggagaaac tactcctgtg      660

gacccagaag gtgacagctg gttacacagg aatcaaatgc accaactttt cctcctgctg      720

gagtgatggg aagatgttca atgcactcat tcaccgatac cgacccgatc tagtagacat      780

ggagagggtg caaatccaaa gtaaccgaga gaatctggaa caggcttttg aagtggcaga      840

aagactgggg gtcactcgcc tgctggatgc agaagatgtg gatgtgccat ctccagatga      900

aaagtctgta atcacttatg tgtcttcgat ttatgatgcc ttccctaaag ttcctgaggg      960

tggagaaggg atcagtgcta cggaagtgga ctccaggtgg caagaatacc aaagccgagt     1020

ggactccctc attccctgga tcaaacagca tacaatactg atgtcagata aaacttttcc     1080

ccaaaaccct gttgaactaa aggcacttta taaccaatat atacacttca aagaaacaga     1140

aattctggcc aaggagagag aaaaaggaag aattgaggaa ttatataaat tactagaggt     1200

gtggattgaa tttggccgaa ttaaactgcc tcaaggttat caccctaatg atgtggaaga     1260

agagtgggga aagctcatca tagagatgct ggaacgagag aaatcacttc ggccggctgt     1320

ggagaggctg gaattgctgc tacagattgc aaacaaaatc cagaatggtg ctttgaactg     1380

tgaagaaaaa ctgacactag ctaagaatac actgcaggct gatgctgctc acctggaatc     1440

aggacaaccg gtacaatgtg agtcagatgt cattatgtac attcaggagt gtgaaggtct     1500

catcaggcag ctgcaggtgg atctccagat cctgcgggat gagaattact accagctaga     1560

agagctggct tttagggtca tgcgtcttca ggatgagctg gtcaccttgc gtctagagtg     1620

tacaaacctg taccggaagg gtcatttcac ttcacttgaa ttggttccac cctctacttt     1680

aaccaccact catctgaaag cagaaccctt aaccaaggca acccattctt cttctacctc     1740

ctggttccga aagcctatga ctcgggctga acttgtggcc atcagctcct ctgaagatga     1800

aggcaatctc cgatttgtgt atgaactact gtcttgggta gaagagatgc agatgaaact     1860

ggagcgagca gagtggggca atgacctgcc tagtgtggag ttgcagctag aaacacagca     1920

gcacatccat acgagtgtag aagagctggg ctcaagtgtc aaggaggcca ggttgtatga     1980

gggaaagatg tcccagaatt tccataccag ctatgctgaa actcttggaa agctggagac     2040

acagtattgt aaattgaagg aaacttctag cttccggatg aggcaccttc agagcctgca     2100

taaatttgtt tccagagcta cagctgagtt gatctggttg aatgagaagg aggaggagga     2160

actagcatat gactggagtg acaacaattc caatatctca gccaagagaa attacttctc     2220

tgagttgaca atggaactgg aggagaaaca ggatgtgttt cgttctctac aagatacagc     2280

agaactactt tcacttgaga accacccagc caagcagaca gtggaggctt acagtgctgc     2340

tgtccagtcc cagttgcagt ggatgaagca gctgtgcctg tgtgttgagc agcatgtgaa     2400

agagaatact gcttattttc agttcttcag tgatgcacga gagctggagt cattcttgag     2460

gaacctccaa gattccatta aacgaaaata ttcctgtgac cacaacacca gcttatcccg     2520

ccttgaagac ctgctccagg actccatgga tgaaaaggag cagcttatac agtccaagag     2580

ttccgttgcc agtctcgttg ggagatcaaa aaccatcgtt cagctaaaac cacgcagtcc     2640

agaccatgtg ttaaagaaca ccatttctgt caaggctgtc tgtgactaca ggcagatcga     2700

gattactatt tgcaaaaatg atgaatgtgt gctagaagat aattctcagc ggaccaaatg     2760

gaaagtgatc agccccacag ggaacgaggc aatggtgccg tcagtctgct tcctcatccc     2820

cccacccaat aaggatgcca ttgagatggc cagcagggtc gaacaatctt atcagaaggt     2880

tatggccctt tggcatcagc tgcatgttaa caccaaaagc cttatctctt ggaactatct     2940

gcgtaaagac cttgaccttg tacagacctg gaacctagaa aagcttcgat cctcagcacc     3000

aggggagtgc catcagatta tgaagaacct tcaggcccac tatgaagact ttctgcagga     3060

tagtcgtgac tctgtgctgt tctcagtggc tgatcgcttg cgcttggaag aggaggtgga     3120

agcttgtaaa gcccgcttcc agcacctgat gaagtccatg gagaatgagg acaaagagga     3180

gactgtggcc aagatgtaca tttcagagtt gaagaacatc cggctacgcc tggaggagta     3240

tgaacagagg gtggtcaaac gaattcagtc tctagccagc tctaggactg acagagatgc     3300

ctggcaggac aatgcattaa ggattgcaga gcaagagcac acccaggagg atttacagca     3360

attgaggtca gacttggatg cagtttctat gaaatgtgac agctttctcc atcagtctcc     3420

atctagttca agtgtcccaa ctctgcgctc agaactgaat ctgctggtgg agaagatgga     3480

ccatgtctat ggtctctcta ctgtatatct gaataagtta aagacagttg atgttatagt     3540

acgtagcata caggatgctg aactcttggt caaaggttat gagattaagc tgagtcaaga     3600

agaagtagta ctggcagatc tctcagctct ggaggcccat tggtcgacat tacggcactg     3660

gcttagtgat gtgaaggaca agaattcagt gttttcagtc ctggatgagg aaattgccaa     3720

ggccaaggta gtggcagagc agatgagtcg tctgacacca gagcgaaatc tggatttgga     3780

gcgctatcag gaaaaaggct cccagctgca ggagcgttgg caccgagtca ttgcccagct     3840

cgagattcgc caatctgagc tagaaagtat ccaggaagtt ctgggagatt accgagcctg     3900

ccatggaact ctcatcaagt ggattgagga aaccactgcc cagcaggaaa tgatgaagcc     3960

aggccaggca gaggatagca gagtgctttc ggagcagctc agccagcaga cggccctatt     4020

tgcagaaatt gagagaaatc agacaaaact ggatcaatgt caaaaatttt cccagcagta     4080

ctctactatt gtaaaggact atgaattgca actgatgaca tacaaggcct ttgtggaatc     4140

gcagcagaaa tcccctggca agcgccgtcg catgctttcc tcttcagatg ccatcactca     4200

agagttcatg gacttaagga ctcgctacac ggcattggtg actttaacaa ctcagcacgt     4260

gaaatacatc agtgatgcac tccggcgtct ggaggaggag gagaaagtgg tagaagagga     4320

gaaacaagaa catgtggaga aggttaaaga acttttgggc tgggtgtcta ccctagcgag     4380

gaatacacaa ggaaaagcta cctcatccga gaccaaagaa tcaacagaca ttgaaaaagc     4440

tattttggaa cagcaggttc tgtcagaaga gctgacaaca aagaaagaac aagtctctga     4500

agctattaaa acatcacaga tcttcttggc caagcatggt cataagctct cagaaaaaga     4560

gaagaaacaa atatctgagc aattgaatgc cctaaacaag gcttaccatg acctttgtga     4620

tggttctgca aatcagcttc agcagcttca gagccagttg gctcaccaga cagaacaaaa     4680

gaccctgcag aaacaacaaa atacctgtca ccagcaactg gaggatcttt gcagttgggt     4740

aggacaggca gaaagagcac tggcaggcca ccaaggcaga accacccagc aggatctctc     4800

tgctttgcag aagaaccaaa gtgacttgaa ggatttacag gatgacattc agaatcgtgc     4860

cacctcattt gccactgttg tcaaggacat tgaggggttc atggaagaga atcagaccaa     4920

gctgagccca cgtgagttga cagctcttcg ggaaaagctt catcaggcta aggagcaata     4980

tgaggcgctc caggaagaga cacgtgtggc ccagaaggaa ctggaggaag cagtgacctc     5040

cgccttacag caggagactg aaaagagtaa agcagcaaag gaactggcag agaacaagaa     5100

gaagatcgat gctctcctgg attgggtaac ttcagtagga tcatctggtg gacagctgct     5160

gaccaacctt ccaggaatgg agcagctctc gggagctagc ttggagaaag gagccttgga     5220

caccactgat ggttacatgg gggtgaatca agccccagag aaactggaca agcaatgtga     5280

gatgatgaag gcccgtcacc aagaattgct gtcccagcag caaaatttca ttctggccac     5340

ccagtcagct caggccttct tggatcagca tggccacaat ctcacacctg aggagcaaca     5400

gatgctgcaa cagaagctgg gagagctaaa ggaacaatac tctacttccc tggcccaatc     5460

agaggcagaa ctgaagcagg tgcagacact tcaggatgag ttgcagaaat ttctgcagga     5520

tcataaagag tttgaaagct ggttggaacg atccgagaaa gagctggaga acatgcataa     5580

gggaggcagc agccccgaga cccttccctc cctgctaaag cggcaaggaa gcttctcaga     5640

ggatgtcatt tcccacaaag gagacttgag atttgtgact atctcaggac agaaagtctt     5700

ggacatggaa aacagtttta aggaaggcaa agaaccatca gaaattggaa acttagtaaa     5760

ggacaagttg aaggatgcaa cagaaagata cactgctctc cactcaaagt gtacacgatt     5820

aggatctcac ctgaatatgc tgttaggcca gtatcatcaa ttccaaaaca gtgctgacag     5880

cctgcaggcc tggatgcagg cttgtgaggc caacgtggag aagctcctct cagatactgt     5940

tgcctctgac cctggagttc tccaggagca gcttgcaaca acaaagcagt tgcaggagga     6000

attggctgag caccaagtac ctgtggaaaa actccaaaaa gtagctcgtg acataatgga     6060

aattgaaggg gagccagccc cagaccacag gcatgttcaa gaaactacag attccatact     6120

cagccacttc caaagcctct cctatagcct ggctgagcga tcttctctgc tgcagaaagc     6180

aattgcccaa tctcagagtg tccaggaaag cctggagagc ctgttgcagt ctattgggga     6240

agttgaacaa aacctggaag ggaagcaggt gtcatcactc tcatcaggag tcatccagga     6300

agccttagcc acaaatatga aattgaagca ggacattgct cggcaaaaga gcagcttgga     6360

ggccacccgt gagatggtga cccgattcat ggagacagca gacagtacta cagcagcagt     6420

gctgcagggc aaactggcag aggtgagcca gcggttcgaa cagctctgtc tacagcagca     6480

agaaaaggag agctccctaa agaagcttct accccaggca gagatgtttg aacacctctc     6540

tggtaagctg cagcagttca tggaaaacaa aagtcggatg ctggcctctg gaaatcagcc     6600

agatcaagat attacacatt tcttccaaca gatccaggag ctcaatttgg aaatggaaga     6660

ccaacaggag aacctagata ctcttgagca cctggtcact gaactgagct cttgtggctt     6720

tgcgctggac ttgtgccagc atcaggacag ggtacagaat ctaagaaaag acttcacaga     6780

gctacagaag acagttaaag agagagagaa agatgcatca tcttgccagg aacagttgga     6840

tgaattccgg aagctggtca ggaccttcca gaaatggttg aaagaaactg aagggagtat     6900

tccacctacg gaaacttcta tgagtgctaa agagttagaa aagcagattg aacacctgaa     6960

gagtctacta gatgactggg caagtaaggg aactctggtg gaagaaatca attgcaaagg     7020

tacttcttta gaaaatctca tcatggaaat cacagcacct gattcccaag gcaagacagg     7080

ttccatactg ccctctgtag gaagctctgt aggcagtgta aacggatacc acacctgcaa     7140

agatctgacg gagatccagt gtgacatgtc agatgtaaac ttgaagtatg agaaactagg     7200

gggagtactt catgaacgcc aggaaagcct tcaggctatc ctcaacagaa tggaggaggt     7260

tcacaaggag gcaaactctg tgctgcagtg gctggaatca aaagaggaag tcctgaaatc     7320

catggatgcc atgtcatctc caaccaagac agaaacagtg aaagcccaag ctgaatctaa     7380

caaggccttc ctggctgagt tggaacagaa ttctccaaaa attcaaaaag taaaggaagc     7440

cctggctgga ttactggtga catatcccaa ctcacaggaa gcagaaaatt ggaagaaaat     7500

tcaggaagaa ctcaattccc gatgggaaag ggccactgag gttactgtgg ctcggcaaag     7560

gcagctagag gaatctgcaa gtcatctggc ctgcttccag gctgcagaat cccagctccg     7620

gccgtggctg atggagaaag aactgatgat gggagtgctg gggcccctgt ctattgaccc     7680

caacatgttg aatgcacaaa agcaacaggt ccagtttatg ctaaaggaat ttgaagcacg     7740

caggcaacag catgagcaac tgaatgaggc agctcagggc atcctaacag gccctggaga     7800

tgtctctctg tccaccagcc aagtacagaa agaactccag agcatcaatc agaaatgggt     7860

tgagctgact gacaaactca actcccgttc cagccaaatt gaccaagcta ttgttaagag     7920

cacccagtac caggaactgc tccaggactt atcagagaag gtgagggcag ttggacaacg     7980

gctgagtgtc cagtcagcta tcagcaccca accagaggct gtaaagcagc aattggaaga     8040

gaccagtgaa attcgatctg acttggagca gttagaccac gaggttaagg aggctcagac     8100

actgtgcgat gaactctcag tgctcattgg tgagcagtac ctcaaggatg aactgaagaa     8160

gcgtttggag acagttgccc tgcctctcca aggtttagaa gaccttgcag ccgatcgcat     8220

taacagactc caggcagctc ttgccagcac ccagcagttc cagcaaatgt ttgatgagtt     8280

gaggacctgg ttggatgata aacaaagcca gcaagcaaaa aactgcccaa tttctgcaaa     8340

attggagcgg ctacagtctc agctacagga gaatgaagag tttcagaaaa gtcttaatca     8400

acacagtggc tcctatgagg tgattgtggc tgaaggggaa tctctacttc tttctgtacc     8460

tcctggagaa gagaaaagga ctctacaaaa ccagttggtt gagctcaaaa accattggga     8520

agagcttagt aaaaaaactg cagacagaca atccaggctc aaggattgta tgcagaaagc     8580

tcagaaatat cagtggcatg tggaagacct tgtgccatgg atagaagatt gtaaagctaa     8640

gatgtctgag ttgcgagtca ctctggatcc agtgcagcta gagtccagtc tcctaagatc     8700

aaaggctatg ctgaatgagg tggagaagcg ccgctccctg ctggaaatat tgaatagtgc     8760

tgctgacatt ctgatcaatt cttcagaagc agatgaggat ggaatccggg atgagaaggc     8820

tgggatcaac cagaacatgg atgctgttac agaagagctg caggccaaaa cagggtcact     8880

cgaagaaatg actcagaggc tcagggagtt ccaggaaagc tttaagaata ttgaaaagaa     8940

ggttgaagga gccaaacacc aacttgagat ctttgatgct ctgggttctc aagcctgtag     9000

caacaagaac ctggagaagc taagagctca acaggaagtg ctgcaggccc tagagcctca     9060

ggtagactat ctgaggaact ttactcaggg tctggtagaa gatgccccag atggatctga     9120

tgcttctcaa cttctccacc aagctgaggt cgcccagcaa gagttcctcg aagttaagca     9180

aagagtgaac agtggttgtg tgatgatgga aaacaagctg gaggggattg gccagtttca     9240

ctgccgggtc cgagagatgt tctctcaatt ggcagacctg gatgatgagc tagatggcat     9300

gggtgctatt ggcagagaca ctgatagcct ccagtcccaa atcgaggatg tccggctatt     9360

ccttaacaaa attcacgtcc tcaaattaga catagaggcc tctgaagcag agtgtcgaca     9420

tatgctagaa gaagagggga ctctggattt gttaggtctc aaaagggagc tagaagccct     9480

gaacaaacag tgtggcaaac tgacagagag ggggaaagct cgtcaggaac agctggaact     9540

gacactaggc cgtgtagagg acttctacag gaaattgaaa ggactcaatg acgcgaccac     9600

agcagcagag gaggcagagg ccctccagtg ggtagtgggg accgaagtgg aaatcatcaa     9660

ccaacaatta gcagatttta aaatgtttca gaaagaacaa gtggatcctc ttcagatgaa     9720

attgcagcag gtgaatggac ttggccaggg attaattcag agtgcaggaa aagactgtga     9780

tgtacagggt ttagaacatg acatggaaga gatcaatgct cgatggaata cattgaataa     9840

aaaggtcgca caaagaattg cacagctaca ggaagctttg ttgcattgtg ggaagtttca     9900

agatgccttg gagccattgc tcagctggtt ggcagatacc gaggagctca tagccaatca     9960

gaaacctcca tctgctgagt ataaagtggt gaaagcacag atccaagaac agaagttgct    10020

ccagcggctc ctagatgatc gaaaggccac agtagacatg cttcaagcag aaggaggcag    10080

aatagcccag tcagcagagc tggctgatag agagaaaatc actggacagc tggagagtct    10140

tgaaagtaga tggactgaac tactcagtaa ggcagcagcc aggcaaaaac agctggaaga    10200

catcctggtt ctggccaaac agttccatga gacagctgag cctatttctg acttcttatc    10260

tgtcacagag aaaaagcttg ctaactcaga acctgttggc actcagactg ccaaaataca    10320

gcagcagatc attcggcaca aggctctgga agaagacata gaaaaccatg caacagatgt    10380

gcaccaggca gtcaaaattg ggcagtccct ctcctccctg acatctcctg cagaacaggg    10440

tgtgctgtca gaaaagatag actcattgca ggcccgatac agtgaaattc aagaccgctg    10500

ttgtcggaag gcagccctac ttgaccaagc tctgtctaat gctaggctgt ttggggagga    10560

tgaggtggag gtgctcaact ggctggctga ggttgaggac aagctcagtt cagtgttcgt    10620

aaaggatttc aaacaggatg tcctgcacag gcagcatgct gaccacctgg ctttaaatga    10680

agaaattgtt aatagaaaga agaatgtaga tcaagctatt aaaaatggtc aggctcttct    10740

aaaacaaacc acaggtgagg aggtgttact tatccaggaa aaactagatg gtataaagac    10800

tcgttacgca gacatcacag ttactagctc caaggccctc agaactttag agcaagcccg    10860

gcagctggcc accaagttcc agtctactta tgaggaactg accgggtggc tgagggaggt    10920

ggaggaggag ctggcaacca gtggaggaca gtctcccaca ggggaacaga taccccagtt    10980

tcagcagaga cagaaggaat taaagaagga ggtcatggag cacaggctgg tgttggacac    11040

agtgaatgag gtgagccgtg ctctcttaga gctggtgccc tggagagcca gagaagggct    11100

ggataaactt gtgtccgatg ctaacgagca gtacaaacta gtcagtgaca ctattggaca    11160

aagggtggat gaaattgatg ctgctattca gagatcacaa cagtatgagc aagctgccga    11220

tgcagaacta gcttgggttg ctgaaacaaa acggaaactg atggctctgg gtccaattcg    11280

cctggaacag gaccagacca cagctcagct tcaggtacag aaggctttct ccattgacat    11340

tattcgacac aaagattcaa tggatgaact cttcagtcac cgtagtgaaa tctttggcac    11400

atgtggggag gagcaaaaaa ctgtattaca ggaaaagaca gagtctctaa tacagcaata    11460

tgaagccatt agcctactca attcagagcg ttatgcccgc ctagagcggg cccaggtctt    11520

agtaaaccag ttttgggaaa cttatgaaga gctcagcccc tggattgagg aaactcgggc    11580

actaatagca cagttaccct ctccagccat tgatcatgag cagctcaggc agcaacaaga    11640

ggaaatgagg caattaaggg aatctattgc tgaacacaaa cctcatattg acaaactact    11700

aaagataggc ccacaactaa aggaattaaa ccctgaggaa ggggaaatgg tggaagaaaa    11760

ataccagaaa gcagaaaaca tgtatgccca aataaaggag gaggtgcgcc agcgagccct    11820

ggctctggat gaagccgtgt cccagtccac acagattaca gagtttcatg ataaaattga    11880

gcctatgttg gagacactgg agaatctttc ctctcgcctg cgtatgccac cactgatccc    11940

tgctgaagta gacaagatca gagagtgcat cagtgacaat aagagtgcca ccgtggagct    12000

agaaaaactg cagccatcct ttgaggcctt gaagcgccgt ggagaggagc ttattggacg    12060

atctcaggga gcagacaagg atctggctgc aaaagaaatc caggataaat tggatcaaat    12120

ggtattcttc tgggaggaca tcaaagctcg ggctgaagaa cgagaaatca aatttcttga    12180

tgtccttgaa ttagcagaga agttctggta tgacatggca gctctcctga ccaccatcaa    12240

agacacccag gatattgtcc atgacttgga aagcccaggc attgatcctt ccatcatcaa    12300

acaacaggtt gaagctgctg agactattaa ggaagagaca gatggtctgc atgaagagct    12360

ggagtttatt cggatccttg gagcagattt gatttttgcc tgtggagaaa ctgagaagcc    12420

tgaagtgagg aagagcattg atgagatgaa taatgcttgg gagaacttaa acaaaacatg    12480

gaaagagagg ctagaaaaac ttgaggatgc tatgcaagct gctgtgcagt atcaggacac    12540

tcttcaggct atgtttgact ggctagataa cactgtgatt aaactctgca ccatgccccc    12600

tgttggcact gacctcaata ctgttaaaga tcagttaaat gaaatgaagg agttcaaagt    12660

agaagtttac caacagcaaa ttgagatgga gaagcttaat caccagggtg aactgatgtt    12720

aaagaaagct actgatgaga cggacagaga cattatacga gaaccactga cagaactcaa    12780

acacctctgg gagaacctgg gtgagaaaat tgcccaccga cagcacaaac tagaaggggc    12840

tctgttggcc cttggtcagt tccagcatgc cttagaggaa ctaatgagtt ggctgactca    12900

taccgaagag ttgttagatg ctcagagacc aataagtgga gacccaaaag tcattgaagt    12960

tgagctcgca aagcaccatg tcctaaaaaa tgatgttttg gctcatcaag ccacagtgga    13020

aacagtcaac aaagctggca atgagcttct tgaatccagt gctggagatg atgccagcag    13080

cttaaggagc cgtttggaag ccatgaacca atgctgggag tcagtgttac agaaaacaga    13140

ggagagggag cagcagcttc agtcaactct gcagcaggcc cagggcttcc acagtgaaat    13200

tgaagatttc ctcttggaac ttactagaat ggagagccag ctttctgcat ctaagcccac    13260

aggaggactt cctgaaactg ctagggaaca gcttgataca catatggaac tctattccca    13320

gctgaaagcc aaggaagaga cttataatca actacttgac aagggcagac tcatgcttct    13380

aagccgtgac gactctgggt ctggctccaa gacagaacag agtgtagcac ttttggagca    13440

gaagtggcat gtggtcagca gtaagatgga agaaagaaag tcaaagctgg aagaggccct    13500

caacttggca acagaattcc agaattccct acaagaattt atcaactggc tcactctagc    13560

agagcagagt ttaaacatcg cttctccacc aagcctgatt ctaaatactg tcctttccca    13620

gatagaagag cacaaggttt ttgctaatga agtaaatgct catcgagacc agatcattga    13680

gctggatcaa actgggaatc aattaaagtt ccttagccaa aagcaggatg ttgttctgat    13740

caagaatttg ttggtgagcg tgcagtctcg atgggagaag gttgtccagc gatctattga    13800

aagagggcga tcactagatg atgccaggaa gcgggcaaaa caattccatg aagcttggaa    13860

aaaactgatt gactggctag aagatgcaga gagtcacctg gactcagaac tagagatatc    13920

caatgaccca gacaaaatta aacttcagct ttctaagcat aaggagtttc agaagactct    13980

tggtggcaag cagcctgtgt atgataccac aattagaact ggcagagcac tgaaagaaaa    14040

gactttgctt cccgaagata gtcagaaact tgacaatttc ctaggagaag tcagagacaa    14100

atgggatact gtttgtggca agtctgtgga gcggcagcac aagttggagg aagccctgct    14160

cttttcgggt cagttcatgg atgctttgca ggcattggtt gactggttat acaaggtgga    14220

gccacagctg gctgaggacc agcccgtgca cggggacctt gacctcgtca tgaacctcat    14280

ggatgcacac aaggttttcc agaaggaact gggaaagcga acaggaaccg ttcaggtcct    14340

gaagcggtca ggccgagagc tgattgagaa tagtcgagat gacaccactt gggtaaaagg    14400

acagctccag gaactgagca ctcgctggga cactgtctgt aaactctctg tttccaaaca    14460

aagccggctt gagcaggcct taaaacaagc ggaagtgttt cgagacacag tccacatgct    14520

gttggagtgg ctttctgaag cagagcaaac gcttcgcttt cggggagcac ttcctgatga    14580

cacagaggcc ctgcagtctc tcattgacac ccataaggaa ttcatgaaga aagtagaaga    14640

aaagcgagtg gacgttaact cagcagtagc catgggagaa gtcatcctgg ctgtctgcca    14700

ccccgattgc atcacaacca tcaaacactg gatcaccatc atccgagctc gcttcgagga    14760

ggtcctgaca tgggctaagc agcaccagca gcgtcttgaa acggccttgt cagaactggt    14820

ggctaatgct gagctcctgg aagaacttct ggcatggatc cagtgggctg agaccaccct    14880

cattcagcgg gatcaggagc caatcccgca gaacattgac cgagttaaag cccttatcgc    14940

tgagcatcag acatttatgg aggagatgac tcgcaaacag cctgacgtgg accgggtcac    15000

caagacatac aaaaggaaaa acatagagcc tactcacgcg cctttcatag agaaatcccg    15060

cagcggaggc aggaaatccc taagtcagcc aacccctcct cccatgccaa tcctttcaca    15120

gtctgaagca aaaaacccac ggatcaacca gctttctgcc cgctggcagc aggtgtggct    15180

gttagcactg gagcggcaaa ggaaactgaa tgatgccttg gatcggctgg aggagttgaa    15240

agaatttgcc aactttgact ttgatgtctg gaggaaaaag tatatgcgtt ggatgaatca    15300

caaaaagtct cgagtgatgg atttcttccg gcgcattgat aaggaccagg atgggaagat    15360

aacacgtcag gagtttatcg atggcatttt agcatccaag ttccccacca ccaagttaga    15420

gatgactgct gtggctgaca ttttcgaccg agatggggat ggttacattg attattatga    15480

atttgtggct gctcttcatc ccaacaagga tgcgtatcga ccaacaaccg atgcagataa    15540

aatcgaagat gaggttacaa gacaagtggc tcagtgcaaa tgtgcaaaaa ggtttcaggt    15600

ggagcagatc ggagagaata aataccggtt tggggattct cagcagttgc ggctggtccg    15660

tattctgcgc agcaccgtga tggttcgcgt tggtggagga tggatggcct tggatgaatt    15720

tttagtgaaa aatgatccct gccgagcacg aggtagaact aacattgaac ttagagagaa    15780

attcatccta ccagagggag catcccaggg aatgaccccc ttccgctcac ggggtcgaag    15840

gtccaaacca tcttcccggg cagcttcccc tactcgttcc agctccagtg ctagtcagag    15900

taaccacagc tgtacatcca tgccatcttc tccagccacc ccagccagtg gaaccaaggt    15960

tatcccatca tcaggtagca agttgaaacg accaacacca acttttcatt ctagtcggac    16020

atcccttgct ggtgatacca gcaatagttc ttccccggcc tccacaggtg ccaaaactaa    16080

tcgggcagac cctaaaaagt ctgccagtcg ccctgggagt cgggctggga gtcgagccgg    16140

gagtcgagcc agcagccggc gaggaagtga cgcttctgac tttgacctct tagagacgca    16200

gtctgcttgt tccgacactt cagaaagcag cgctgcaggg ggccaaggca actccaggag    16260

agggctaaac aaaccttcca aaatcccaac catgtctaag aagaccacca ctgcctcccc    16320

caggactcca ggtcccaagc gataacactg tctaagcacc cccaagccac tatccacttt    16380

gaatcctgct ccatacattg ggtgtatatt tattctgaac gggagaagtt atattgttaa    16440

aagtgtaaaa gaataattgt gttatgaagc tgccttattt tttttctttt tgtaagttac    16500

tattttcatg tgaatattta tgtagataaa atttgcctcc tggtaaccct gtaatggatg    16560

gggcccagaa atgaaatatt tgagaaaaac aagtgaaaag gtcaagatac aaatgtgtat    16620

taaaaaaaaa aaagcctatt aatagggttt ctgcgcggtg cagggttgta aacctgcttt    16680

atcttttagg attattccta aatgcatctt ctttataaac ttgacttgct atctcagcaa    16740

gataaattat attaaaaaaa taagaatcct gcagtgttta aggaactctt tttttgtaaa    16800

tcacggacac ctcaattagc aagaactgag gggagggctt tttccattgt ttaatgtttt    16860

gtgattttta gctaaagaga gggaacctca tctaagtaac atttgcacat gatacagcaa    16920

aaggagttca ttgcaatact gtctttggat attgtttcag tactgggtgt ttaaaggaca    16980

aatagctgct agaattcagg ggtaaatgta agtgttcaga aaacgtcaga acatttgggg    17040

ttttaaactg atttgttgct ccctatccag cctagacacc agtaactctt gtgttcacca    17100

ggacccagac ccttggcaag ggataggctc gttggtgaca ttgtgaattt cagatttgtt    17160

ttatccactt tttttgctat ttatttaaat ggtcgatcaa cttcccacaa actgaggaat    17220

gaattccacg agcctgttct gaaaatgtgg acgtaagaca aacacgtgct cgtcctttaa    17280

tggagttcac cagcacactt gttaaccagt cctgtttgct ttcgtctttt tttgtgcgta    17340

ataaagtcaa ctgaccaagt gaccatgaaa aggggctgtc tggggctcct gttttttagc    17400

tgctgttctt cagctccgac catgttgctg tgtgattatc tcaattggtt ttaattgagg    17460

cagaaactga agctctacca atgaactgtt tagaaacaag acacactttt gtattaaaat    17520

tgcttgcagt aacaaatatt ttgtatttcc tgattttctt ttcaactatt accttatcta    17580

taaatgttac cctggggtat aatcatgttg taggtactta aatgcattcc gcaaatcaaa    17640

atatcttgat ggataaatta tagagcttaa tagatcttgt tttatttcaa aaaaaaaaaa    17700

a                                                                    17701


<210>  2
<211>  5430
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Ser Asp Glu Glu Thr Leu Ser Glu Arg Ser Cys Arg Ser 
1               5                   10                  15      


Glu Arg Ser Cys Arg Ser Glu Arg Ser Tyr Arg Ser Glu Arg Ser Gly 
            20                  25                  30          


Ser Leu Ser Pro Cys Pro Pro Gly Asp Thr Leu Pro Trp Asn Leu Pro 
        35                  40                  45              


Leu His Glu Gln Lys Lys Arg Lys Ser Gln Asp Ser Val Leu Asp Pro 
    50                  55                  60                  


Ala Glu Arg Ala Val Val Arg Val Ala Asp Glu Arg Asp Arg Val Gln 
65                  70                  75                  80  


Lys Lys Thr Phe Thr Lys Trp Val Asn Lys His Leu Met Lys Val Arg 
                85                  90                  95      


Lys His Ile Asn Asp Leu Tyr Glu Asp Leu Arg Asp Gly His Asn Leu 
            100                 105                 110         


Ile Ser Leu Leu Glu Val Leu Ser Gly Ile Lys Leu Pro Arg Glu Lys 
        115                 120                 125             


Gly Arg Met Arg Phe His Arg Leu Gln Asn Val Gln Ile Ala Leu Asp 
    130                 135                 140                 


Phe Leu Lys Gln Arg Gln Val Lys Leu Val Asn Ile Arg Asn Asp Asp 
145                 150                 155                 160 


Ile Thr Asp Gly Asn Pro Lys Leu Thr Leu Gly Leu Ile Trp Thr Ile 
                165                 170                 175     


Ile Leu His Phe Gln Ile Ser Asp Ile Tyr Ile Ser Gly Glu Ser Gly 
            180                 185                 190         


Asp Met Ser Ala Lys Glu Lys Leu Leu Leu Trp Thr Gln Lys Val Thr 
        195                 200                 205             


Ala Gly Tyr Thr Gly Ile Lys Cys Thr Asn Phe Ser Ser Cys Trp Ser 
    210                 215                 220                 


Asp Gly Lys Met Phe Asn Ala Leu Ile His Arg Tyr Arg Pro Asp Leu 
225                 230                 235                 240 


Val Asp Met Glu Arg Val Gln Ile Gln Ser Asn Arg Glu Asn Leu Glu 
                245                 250                 255     


Gln Ala Phe Glu Val Ala Glu Arg Leu Gly Val Thr Arg Leu Leu Asp 
            260                 265                 270         


Ala Glu Asp Val Asp Val Pro Ser Pro Asp Glu Lys Ser Val Ile Thr 
        275                 280                 285             


Tyr Val Ser Ser Ile Tyr Asp Ala Phe Pro Lys Val Pro Glu Gly Gly 
    290                 295                 300                 


Glu Gly Ile Ser Ala Thr Glu Val Asp Ser Arg Trp Gln Glu Tyr Gln 
305                 310                 315                 320 


Ser Arg Val Asp Ser Leu Ile Pro Trp Ile Lys Gln His Thr Ile Leu 
                325                 330                 335     


Met Ser Asp Lys Thr Phe Pro Gln Asn Pro Val Glu Leu Lys Ala Leu 
            340                 345                 350         


Tyr Asn Gln Tyr Ile His Phe Lys Glu Thr Glu Ile Leu Ala Lys Glu 
        355                 360                 365             


Arg Glu Lys Gly Arg Ile Glu Glu Leu Tyr Lys Leu Leu Glu Val Trp 
    370                 375                 380                 


Ile Glu Phe Gly Arg Ile Lys Leu Pro Gln Gly Tyr His Pro Asn Asp 
385                 390                 395                 400 


Val Glu Glu Glu Trp Gly Lys Leu Ile Ile Glu Met Leu Glu Arg Glu 
                405                 410                 415     


Lys Ser Leu Arg Pro Ala Val Glu Arg Leu Glu Leu Leu Leu Gln Ile 
            420                 425                 430         


Ala Asn Lys Ile Gln Asn Gly Ala Leu Asn Cys Glu Glu Lys Leu Thr 
        435                 440                 445             


Leu Ala Lys Asn Thr Leu Gln Ala Asp Ala Ala His Leu Glu Ser Gly 
    450                 455                 460                 


Gln Pro Val Gln Cys Glu Ser Asp Val Ile Met Tyr Ile Gln Glu Cys 
465                 470                 475                 480 


Glu Gly Leu Ile Arg Gln Leu Gln Val Asp Leu Gln Ile Leu Arg Asp 
                485                 490                 495     


Glu Asn Tyr Tyr Gln Leu Glu Glu Leu Ala Phe Arg Val Met Arg Leu 
            500                 505                 510         


Gln Asp Glu Leu Val Thr Leu Arg Leu Glu Cys Thr Asn Leu Tyr Arg 
        515                 520                 525             


Lys Gly His Phe Thr Ser Leu Glu Leu Val Pro Pro Ser Thr Leu Thr 
    530                 535                 540                 


Thr Thr His Leu Lys Ala Glu Pro Leu Thr Lys Ala Thr His Ser Ser 
545                 550                 555                 560 


Ser Thr Ser Trp Phe Arg Lys Pro Met Thr Arg Ala Glu Leu Val Ala 
                565                 570                 575     


Ile Ser Ser Ser Glu Asp Glu Gly Asn Leu Arg Phe Val Tyr Glu Leu 
            580                 585                 590         


Leu Ser Trp Val Glu Glu Met Gln Met Lys Leu Glu Arg Ala Glu Trp 
        595                 600                 605             


Gly Asn Asp Leu Pro Ser Val Glu Leu Gln Leu Glu Thr Gln Gln His 
    610                 615                 620                 


Ile His Thr Ser Val Glu Glu Leu Gly Ser Ser Val Lys Glu Ala Arg 
625                 630                 635                 640 


Leu Tyr Glu Gly Lys Met Ser Gln Asn Phe His Thr Ser Tyr Ala Glu 
                645                 650                 655     


Thr Leu Gly Lys Leu Glu Thr Gln Tyr Cys Lys Leu Lys Glu Thr Ser 
            660                 665                 670         


Ser Phe Arg Met Arg His Leu Gln Ser Leu His Lys Phe Val Ser Arg 
        675                 680                 685             


Ala Thr Ala Glu Leu Ile Trp Leu Asn Glu Lys Glu Glu Glu Glu Leu 
    690                 695                 700                 


Ala Tyr Asp Trp Ser Asp Asn Asn Ser Asn Ile Ser Ala Lys Arg Asn 
705                 710                 715                 720 


Tyr Phe Ser Glu Leu Thr Met Glu Leu Glu Glu Lys Gln Asp Val Phe 
                725                 730                 735     


Arg Ser Leu Gln Asp Thr Ala Glu Leu Leu Ser Leu Glu Asn His Pro 
            740                 745                 750         


Ala Lys Gln Thr Val Glu Ala Tyr Ser Ala Ala Val Gln Ser Gln Leu 
        755                 760                 765             


Gln Trp Met Lys Gln Leu Cys Leu Cys Val Glu Gln His Val Lys Glu 
    770                 775                 780                 


Asn Thr Ala Tyr Phe Gln Phe Phe Ser Asp Ala Arg Glu Leu Glu Ser 
785                 790                 795                 800 


Phe Leu Arg Asn Leu Gln Asp Ser Ile Lys Arg Lys Tyr Ser Cys Asp 
                805                 810                 815     


His Asn Thr Ser Leu Ser Arg Leu Glu Asp Leu Leu Gln Asp Ser Met 
            820                 825                 830         


Asp Glu Lys Glu Gln Leu Ile Gln Ser Lys Ser Ser Val Ala Ser Leu 
        835                 840                 845             


Val Gly Arg Ser Lys Thr Ile Val Gln Leu Lys Pro Arg Ser Pro Asp 
    850                 855                 860                 


His Val Leu Lys Asn Thr Ile Ser Val Lys Ala Val Cys Asp Tyr Arg 
865                 870                 875                 880 


Gln Ile Glu Ile Thr Ile Cys Lys Asn Asp Glu Cys Val Leu Glu Asp 
                885                 890                 895     


Asn Ser Gln Arg Thr Lys Trp Lys Val Ile Ser Pro Thr Gly Asn Glu 
            900                 905                 910         


Ala Met Val Pro Ser Val Cys Phe Leu Ile Pro Pro Pro Asn Lys Asp 
        915                 920                 925             


Ala Ile Glu Met Ala Ser Arg Val Glu Gln Ser Tyr Gln Lys Val Met 
    930                 935                 940                 


Ala Leu Trp His Gln Leu His Val Asn Thr Lys Ser Leu Ile Ser Trp 
945                 950                 955                 960 


Asn Tyr Leu Arg Lys Asp Leu Asp Leu Val Gln Thr Trp Asn Leu Glu 
                965                 970                 975     


Lys Leu Arg Ser Ser Ala Pro Gly Glu Cys His Gln Ile Met Lys Asn 
            980                 985                 990         


Leu Gln Ala His Tyr Glu Asp Phe  Leu Gln Asp Ser Arg  Asp Ser Val 
        995                 1000                 1005             


Leu Phe  Ser Val Ala Asp Arg  Leu Arg Leu Glu Glu  Glu Val Glu 
    1010                 1015                 1020             


Ala Cys  Lys Ala Arg Phe Gln  His Leu Met Lys Ser  Met Glu Asn 
    1025                 1030                 1035             


Glu Asp  Lys Glu Glu Thr Val  Ala Lys Met Tyr Ile  Ser Glu Leu 
    1040                 1045                 1050             


Lys Asn  Ile Arg Leu Arg Leu  Glu Glu Tyr Glu Gln  Arg Val Val 
    1055                 1060                 1065             


Lys Arg  Ile Gln Ser Leu Ala  Ser Ser Arg Thr Asp  Arg Asp Ala 
    1070                 1075                 1080             


Trp Gln  Asp Asn Ala Leu Arg  Ile Ala Glu Gln Glu  His Thr Gln 
    1085                 1090                 1095             


Glu Asp  Leu Gln Gln Leu Arg  Ser Asp Leu Asp Ala  Val Ser Met 
    1100                 1105                 1110             


Lys Cys  Asp Ser Phe Leu His  Gln Ser Pro Ser Ser  Ser Ser Val 
    1115                 1120                 1125             


Pro Thr  Leu Arg Ser Glu Leu  Asn Leu Leu Val Glu  Lys Met Asp 
    1130                 1135                 1140             


His Val  Tyr Gly Leu Ser Thr  Val Tyr Leu Asn Lys  Leu Lys Thr 
    1145                 1150                 1155             


Val Asp  Val Ile Val Arg Ser  Ile Gln Asp Ala Glu  Leu Leu Val 
    1160                 1165                 1170             


Lys Gly  Tyr Glu Ile Lys Leu  Ser Gln Glu Glu Val  Val Leu Ala 
    1175                 1180                 1185             


Asp Leu  Ser Ala Leu Glu Ala  His Trp Ser Thr Leu  Arg His Trp 
    1190                 1195                 1200             


Leu Ser  Asp Val Lys Asp Lys  Asn Ser Val Phe Ser  Val Leu Asp 
    1205                 1210                 1215             


Glu Glu  Ile Ala Lys Ala Lys  Val Val Ala Glu Gln  Met Ser Arg 
    1220                 1225                 1230             


Leu Thr  Pro Glu Arg Asn Leu  Asp Leu Glu Arg Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Gly Ser  Gln Leu Gln Glu Arg  Trp His Arg Val Ile  Ala Gln Leu 
    1250                 1255                 1260             


Glu Ile  Arg Gln Ser Glu Leu  Glu Ser Ile Gln Glu  Val Leu Gly 
    1265                 1270                 1275             


Asp Tyr  Arg Ala Cys His Gly  Thr Leu Ile Lys Trp  Ile Glu Glu 
    1280                 1285                 1290             


Thr Thr  Ala Gln Gln Glu Met  Met Lys Pro Gly Gln  Ala Glu Asp 
    1295                 1300                 1305             


Ser Arg  Val Leu Ser Glu Gln  Leu Ser Gln Gln Thr  Ala Leu Phe 
    1310                 1315                 1320             


Ala Glu  Ile Glu Arg Asn Gln  Thr Lys Leu Asp Gln  Cys Gln Lys 
    1325                 1330                 1335             


Phe Ser  Gln Gln Tyr Ser Thr  Ile Val Lys Asp Tyr  Glu Leu Gln 
    1340                 1345                 1350             


Leu Met  Thr Tyr Lys Ala Phe  Val Glu Ser Gln Gln  Lys Ser Pro 
    1355                 1360                 1365             


Gly Lys  Arg Arg Arg Met Leu  Ser Ser Ser Asp Ala  Ile Thr Gln 
    1370                 1375                 1380             


Glu Phe  Met Asp Leu Arg Thr  Arg Tyr Thr Ala Leu  Val Thr Leu 
    1385                 1390                 1395             


Thr Thr  Gln His Val Lys Tyr  Ile Ser Asp Ala Leu  Arg Arg Leu 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Val  Glu Glu Glu Lys Gln  Glu His Val 
    1415                 1420                 1425             


Glu Lys  Val Lys Glu Leu Leu  Gly Trp Val Ser Thr  Leu Ala Arg 
    1430                 1435                 1440             


Asn Thr  Gln Gly Lys Ala Thr  Ser Ser Glu Thr Lys  Glu Ser Thr 
    1445                 1450                 1455             


Asp Ile  Glu Lys Ala Ile Leu  Glu Gln Gln Val Leu  Ser Glu Glu 
    1460                 1465                 1470             


Leu Thr  Thr Lys Lys Glu Gln  Val Ser Glu Ala Ile  Lys Thr Ser 
    1475                 1480                 1485             


Gln Ile  Phe Leu Ala Lys His  Gly His Lys Leu Ser  Glu Lys Glu 
    1490                 1495                 1500             


Lys Lys  Gln Ile Ser Glu Gln  Leu Asn Ala Leu Asn  Lys Ala Tyr 
    1505                 1510                 1515             


His Asp  Leu Cys Asp Gly Ser  Ala Asn Gln Leu Gln  Gln Leu Gln 
    1520                 1525                 1530             


Ser Gln  Leu Ala His Gln Thr  Glu Gln Lys Thr Leu  Gln Lys Gln 
    1535                 1540                 1545             


Gln Asn  Thr Cys His Gln Gln  Leu Glu Asp Leu Cys  Ser Trp Val 
    1550                 1555                 1560             


Gly Gln  Ala Glu Arg Ala Leu  Ala Gly His Gln Gly  Arg Thr Thr 
    1565                 1570                 1575             


Gln Gln  Asp Leu Ser Ala Leu  Gln Lys Asn Gln Ser  Asp Leu Lys 
    1580                 1585                 1590             


Asp Leu  Gln Asp Asp Ile Gln  Asn Arg Ala Thr Ser  Phe Ala Thr 
    1595                 1600                 1605             


Val Val  Lys Asp Ile Glu Gly  Phe Met Glu Glu Asn  Gln Thr Lys 
    1610                 1615                 1620             


Leu Ser  Pro Arg Glu Leu Thr  Ala Leu Arg Glu Lys  Leu His Gln 
    1625                 1630                 1635             


Ala Lys  Glu Gln Tyr Glu Ala  Leu Gln Glu Glu Thr  Arg Val Ala 
    1640                 1645                 1650             


Gln Lys  Glu Leu Glu Glu Ala  Val Thr Ser Ala Leu  Gln Gln Glu 
    1655                 1660                 1665             


Thr Glu  Lys Ser Lys Ala Ala  Lys Glu Leu Ala Glu  Asn Lys Lys 
    1670                 1675                 1680             


Lys Ile  Asp Ala Leu Leu Asp  Trp Val Thr Ser Val  Gly Ser Ser 
    1685                 1690                 1695             


Gly Gly  Gln Leu Leu Thr Asn  Leu Pro Gly Met Glu  Gln Leu Ser 
    1700                 1705                 1710             


Gly Ala  Ser Leu Glu Lys Gly  Ala Leu Asp Thr Thr  Asp Gly Tyr 
    1715                 1720                 1725             


Met Gly  Val Asn Gln Ala Pro  Glu Lys Leu Asp Lys  Gln Cys Glu 
    1730                 1735                 1740             


Met Met  Lys Ala Arg His Gln  Glu Leu Leu Ser Gln  Gln Gln Asn 
    1745                 1750                 1755             


Phe Ile  Leu Ala Thr Gln Ser  Ala Gln Ala Phe Leu  Asp Gln His 
    1760                 1765                 1770             


Gly His  Asn Leu Thr Pro Glu  Glu Gln Gln Met Leu  Gln Gln Lys 
    1775                 1780                 1785             


Leu Gly  Glu Leu Lys Glu Gln  Tyr Ser Thr Ser Leu  Ala Gln Ser 
    1790                 1795                 1800             


Glu Ala  Glu Leu Lys Gln Val  Gln Thr Leu Gln Asp  Glu Leu Gln 
    1805                 1810                 1815             


Lys Phe  Leu Gln Asp His Lys  Glu Phe Glu Ser Trp  Leu Glu Arg 
    1820                 1825                 1830             


Ser Glu  Lys Glu Leu Glu Asn  Met His Lys Gly Gly  Ser Ser Pro 
    1835                 1840                 1845             


Glu Thr  Leu Pro Ser Leu Leu  Lys Arg Gln Gly Ser  Phe Ser Glu 
    1850                 1855                 1860             


Asp Val  Ile Ser His Lys Gly  Asp Leu Arg Phe Val  Thr Ile Ser 
    1865                 1870                 1875             


Gly Gln  Lys Val Leu Asp Met  Glu Asn Ser Phe Lys  Glu Gly Lys 
    1880                 1885                 1890             


Glu Pro  Ser Glu Ile Gly Asn  Leu Val Lys Asp Lys  Leu Lys Asp 
    1895                 1900                 1905             


Ala Thr  Glu Arg Tyr Thr Ala  Leu His Ser Lys Cys  Thr Arg Leu 
    1910                 1915                 1920             


Gly Ser  His Leu Asn Met Leu  Leu Gly Gln Tyr His  Gln Phe Gln 
    1925                 1930                 1935             


Asn Ser  Ala Asp Ser Leu Gln  Ala Trp Met Gln Ala  Cys Glu Ala 
    1940                 1945                 1950             


Asn Val  Glu Lys Leu Leu Ser  Asp Thr Val Ala Ser  Asp Pro Gly 
    1955                 1960                 1965             


Val Leu  Gln Glu Gln Leu Ala  Thr Thr Lys Gln Leu  Gln Glu Glu 
    1970                 1975                 1980             


Leu Ala  Glu His Gln Val Pro  Val Glu Lys Leu Gln  Lys Val Ala 
    1985                 1990                 1995             


Arg Asp  Ile Met Glu Ile Glu  Gly Glu Pro Ala Pro  Asp His Arg 
    2000                 2005                 2010             


His Val  Gln Glu Thr Thr Asp  Ser Ile Leu Ser His  Phe Gln Ser 
    2015                 2020                 2025             


Leu Ser  Tyr Ser Leu Ala Glu  Arg Ser Ser Leu Leu  Gln Lys Ala 
    2030                 2035                 2040             


Ile Ala  Gln Ser Gln Ser Val  Gln Glu Ser Leu Glu  Ser Leu Leu 
    2045                 2050                 2055             


Gln Ser  Ile Gly Glu Val Glu  Gln Asn Leu Glu Gly  Lys Gln Val 
    2060                 2065                 2070             


Ser Ser  Leu Ser Ser Gly Val  Ile Gln Glu Ala Leu  Ala Thr Asn 
    2075                 2080                 2085             


Met Lys  Leu Lys Gln Asp Ile  Ala Arg Gln Lys Ser  Ser Leu Glu 
    2090                 2095                 2100             


Ala Thr  Arg Glu Met Val Thr  Arg Phe Met Glu Thr  Ala Asp Ser 
    2105                 2110                 2115             


Thr Thr  Ala Ala Val Leu Gln  Gly Lys Leu Ala Glu  Val Ser Gln 
    2120                 2125                 2130             


Arg Phe  Glu Gln Leu Cys Leu  Gln Gln Gln Glu Lys  Glu Ser Ser 
    2135                 2140                 2145             


Leu Lys  Lys Leu Leu Pro Gln  Ala Glu Met Phe Glu  His Leu Ser 
    2150                 2155                 2160             


Gly Lys  Leu Gln Gln Phe Met  Glu Asn Lys Ser Arg  Met Leu Ala 
    2165                 2170                 2175             


Ser Gly  Asn Gln Pro Asp Gln  Asp Ile Thr His Phe  Phe Gln Gln 
    2180                 2185                 2190             


Ile Gln  Glu Leu Asn Leu Glu  Met Glu Asp Gln Gln  Glu Asn Leu 
    2195                 2200                 2205             


Asp Thr  Leu Glu His Leu Val  Thr Glu Leu Ser Ser  Cys Gly Phe 
    2210                 2215                 2220             


Ala Leu  Asp Leu Cys Gln His  Gln Asp Arg Val Gln  Asn Leu Arg 
    2225                 2230                 2235             


Lys Asp  Phe Thr Glu Leu Gln  Lys Thr Val Lys Glu  Arg Glu Lys 
    2240                 2245                 2250             


Asp Ala  Ser Ser Cys Gln Glu  Gln Leu Asp Glu Phe  Arg Lys Leu 
    2255                 2260                 2265             


Val Arg  Thr Phe Gln Lys Trp  Leu Lys Glu Thr Glu  Gly Ser Ile 
    2270                 2275                 2280             


Pro Pro  Thr Glu Thr Ser Met  Ser Ala Lys Glu Leu  Glu Lys Gln 
    2285                 2290                 2295             


Ile Glu  His Leu Lys Ser Leu  Leu Asp Asp Trp Ala  Ser Lys Gly 
    2300                 2305                 2310             


Thr Leu  Val Glu Glu Ile Asn  Cys Lys Gly Thr Ser  Leu Glu Asn 
    2315                 2320                 2325             


Leu Ile  Met Glu Ile Thr Ala  Pro Asp Ser Gln Gly  Lys Thr Gly 
    2330                 2335                 2340             


Ser Ile  Leu Pro Ser Val Gly  Ser Ser Val Gly Ser  Val Asn Gly 
    2345                 2350                 2355             


Tyr His  Thr Cys Lys Asp Leu  Thr Glu Ile Gln Cys  Asp Met Ser 
    2360                 2365                 2370             


Asp Val  Asn Leu Lys Tyr Glu  Lys Leu Gly Gly Val  Leu His Glu 
    2375                 2380                 2385             


Arg Gln  Glu Ser Leu Gln Ala  Ile Leu Asn Arg Met  Glu Glu Val 
    2390                 2395                 2400             


His Lys  Glu Ala Asn Ser Val  Leu Gln Trp Leu Glu  Ser Lys Glu 
    2405                 2410                 2415             


Glu Val  Leu Lys Ser Met Asp  Ala Met Ser Ser Pro  Thr Lys Thr 
    2420                 2425                 2430             


Glu Thr  Val Lys Ala Gln Ala  Glu Ser Asn Lys Ala  Phe Leu Ala 
    2435                 2440                 2445             


Glu Leu  Glu Gln Asn Ser Pro  Lys Ile Gln Lys Val  Lys Glu Ala 
    2450                 2455                 2460             


Leu Ala  Gly Leu Leu Val Thr  Tyr Pro Asn Ser Gln  Glu Ala Glu 
    2465                 2470                 2475             


Asn Trp  Lys Lys Ile Gln Glu  Glu Leu Asn Ser Arg  Trp Glu Arg 
    2480                 2485                 2490             


Ala Thr  Glu Val Thr Val Ala  Arg Gln Arg Gln Leu  Glu Glu Ser 
    2495                 2500                 2505             


Ala Ser  His Leu Ala Cys Phe  Gln Ala Ala Glu Ser  Gln Leu Arg 
    2510                 2515                 2520             


Pro Trp  Leu Met Glu Lys Glu  Leu Met Met Gly Val  Leu Gly Pro 
    2525                 2530                 2535             


Leu Ser  Ile Asp Pro Asn Met  Leu Asn Ala Gln Lys  Gln Gln Val 
    2540                 2545                 2550             


Gln Phe  Met Leu Lys Glu Phe  Glu Ala Arg Arg Gln  Gln His Glu 
    2555                 2560                 2565             


Gln Leu  Asn Glu Ala Ala Gln  Gly Ile Leu Thr Gly  Pro Gly Asp 
    2570                 2575                 2580             


Val Ser  Leu Ser Thr Ser Gln  Val Gln Lys Glu Leu  Gln Ser Ile 
    2585                 2590                 2595             


Asn Gln  Lys Trp Val Glu Leu  Thr Asp Lys Leu Asn  Ser Arg Ser 
    2600                 2605                 2610             


Ser Gln  Ile Asp Gln Ala Ile  Val Lys Ser Thr Gln  Tyr Gln Glu 
    2615                 2620                 2625             


Leu Leu  Gln Asp Leu Ser Glu  Lys Val Arg Ala Val  Gly Gln Arg 
    2630                 2635                 2640             


Leu Ser  Val Gln Ser Ala Ile  Ser Thr Gln Pro Glu  Ala Val Lys 
    2645                 2650                 2655             


Gln Gln  Leu Glu Glu Thr Ser  Glu Ile Arg Ser Asp  Leu Glu Gln 
    2660                 2665                 2670             


Leu Asp  His Glu Val Lys Glu  Ala Gln Thr Leu Cys  Asp Glu Leu 
    2675                 2680                 2685             


Ser Val  Leu Ile Gly Glu Gln  Tyr Leu Lys Asp Glu  Leu Lys Lys 
    2690                 2695                 2700             


Arg Leu  Glu Thr Val Ala Leu  Pro Leu Gln Gly Leu  Glu Asp Leu 
    2705                 2710                 2715             


Ala Ala  Asp Arg Ile Asn Arg  Leu Gln Ala Ala Leu  Ala Ser Thr 
    2720                 2725                 2730             


Gln Gln  Phe Gln Gln Met Phe  Asp Glu Leu Arg Thr  Trp Leu Asp 
    2735                 2740                 2745             


Asp Lys  Gln Ser Gln Gln Ala  Lys Asn Cys Pro Ile  Ser Ala Lys 
    2750                 2755                 2760             


Leu Glu  Arg Leu Gln Ser Gln  Leu Gln Glu Asn Glu  Glu Phe Gln 
    2765                 2770                 2775             


Lys Ser  Leu Asn Gln His Ser  Gly Ser Tyr Glu Val  Ile Val Ala 
    2780                 2785                 2790             


Glu Gly  Glu Ser Leu Leu Leu  Ser Val Pro Pro Gly  Glu Glu Lys 
    2795                 2800                 2805             


Arg Thr  Leu Gln Asn Gln Leu  Val Glu Leu Lys Asn  His Trp Glu 
    2810                 2815                 2820             


Glu Leu  Ser Lys Lys Thr Ala  Asp Arg Gln Ser Arg  Leu Lys Asp 
    2825                 2830                 2835             


Cys Met  Gln Lys Ala Gln Lys  Tyr Gln Trp His Val  Glu Asp Leu 
    2840                 2845                 2850             


Val Pro  Trp Ile Glu Asp Cys  Lys Ala Lys Met Ser  Glu Leu Arg 
    2855                 2860                 2865             


Val Thr  Leu Asp Pro Val Gln  Leu Glu Ser Ser Leu  Leu Arg Ser 
    2870                 2875                 2880             


Lys Ala  Met Leu Asn Glu Val  Glu Lys Arg Arg Ser  Leu Leu Glu 
    2885                 2890                 2895             


Ile Leu  Asn Ser Ala Ala Asp  Ile Leu Ile Asn Ser  Ser Glu Ala 
    2900                 2905                 2910             


Asp Glu  Asp Gly Ile Arg Asp  Glu Lys Ala Gly Ile  Asn Gln Asn 
    2915                 2920                 2925             


Met Asp  Ala Val Thr Glu Glu  Leu Gln Ala Lys Thr  Gly Ser Leu 
    2930                 2935                 2940             


Glu Glu  Met Thr Gln Arg Leu  Arg Glu Phe Gln Glu  Ser Phe Lys 
    2945                 2950                 2955             


Asn Ile  Glu Lys Lys Val Glu  Gly Ala Lys His Gln  Leu Glu Ile 
    2960                 2965                 2970             


Phe Asp  Ala Leu Gly Ser Gln  Ala Cys Ser Asn Lys  Asn Leu Glu 
    2975                 2980                 2985             


Lys Leu  Arg Ala Gln Gln Glu  Val Leu Gln Ala Leu  Glu Pro Gln 
    2990                 2995                 3000             


Val Asp  Tyr Leu Arg Asn Phe  Thr Gln Gly Leu Val  Glu Asp Ala 
    3005                 3010                 3015             


Pro Asp  Gly Ser Asp Ala Ser  Gln Leu Leu His Gln  Ala Glu Val 
    3020                 3025                 3030             


Ala Gln  Gln Glu Phe Leu Glu  Val Lys Gln Arg Val  Asn Ser Gly 
    3035                 3040                 3045             


Cys Val  Met Met Glu Asn Lys  Leu Glu Gly Ile Gly  Gln Phe His 
    3050                 3055                 3060             


Cys Arg  Val Arg Glu Met Phe  Ser Gln Leu Ala Asp  Leu Asp Asp 
    3065                 3070                 3075             


Glu Leu  Asp Gly Met Gly Ala  Ile Gly Arg Asp Thr  Asp Ser Leu 
    3080                 3085                 3090             


Gln Ser  Gln Ile Glu Asp Val  Arg Leu Phe Leu Asn  Lys Ile His 
    3095                 3100                 3105             


Val Leu  Lys Leu Asp Ile Glu  Ala Ser Glu Ala Glu  Cys Arg His 
    3110                 3115                 3120             


Met Leu  Glu Glu Glu Gly Thr  Leu Asp Leu Leu Gly  Leu Lys Arg 
    3125                 3130                 3135             


Glu Leu  Glu Ala Leu Asn Lys  Gln Cys Gly Lys Leu  Thr Glu Arg 
    3140                 3145                 3150             


Gly Lys  Ala Arg Gln Glu Gln  Leu Glu Leu Thr Leu  Gly Arg Val 
    3155                 3160                 3165             


Glu Asp  Phe Tyr Arg Lys Leu  Lys Gly Leu Asn Asp  Ala Thr Thr 
    3170                 3175                 3180             


Ala Ala  Glu Glu Ala Glu Ala  Leu Gln Trp Val Val  Gly Thr Glu 
    3185                 3190                 3195             


Val Glu  Ile Ile Asn Gln Gln  Leu Ala Asp Phe Lys  Met Phe Gln 
    3200                 3205                 3210             


Lys Glu  Gln Val Asp Pro Leu  Gln Met Lys Leu Gln  Gln Val Asn 
    3215                 3220                 3225             


Gly Leu  Gly Gln Gly Leu Ile  Gln Ser Ala Gly Lys  Asp Cys Asp 
    3230                 3235                 3240             


Val Gln  Gly Leu Glu His Asp  Met Glu Glu Ile Asn  Ala Arg Trp 
    3245                 3250                 3255             


Asn Thr  Leu Asn Lys Lys Val  Ala Gln Arg Ile Ala  Gln Leu Gln 
    3260                 3265                 3270             


Glu Ala  Leu Leu His Cys Gly  Lys Phe Gln Asp Ala  Leu Glu Pro 
    3275                 3280                 3285             


Leu Leu  Ser Trp Leu Ala Asp  Thr Glu Glu Leu Ile  Ala Asn Gln 
    3290                 3295                 3300             


Lys Pro  Pro Ser Ala Glu Tyr  Lys Val Val Lys Ala  Gln Ile Gln 
    3305                 3310                 3315             


Glu Gln  Lys Leu Leu Gln Arg  Leu Leu Asp Asp Arg  Lys Ala Thr 
    3320                 3325                 3330             


Val Asp  Met Leu Gln Ala Glu  Gly Gly Arg Ile Ala  Gln Ser Ala 
    3335                 3340                 3345             


Glu Leu  Ala Asp Arg Glu Lys  Ile Thr Gly Gln Leu  Glu Ser Leu 
    3350                 3355                 3360             


Glu Ser  Arg Trp Thr Glu Leu  Leu Ser Lys Ala Ala  Ala Arg Gln 
    3365                 3370                 3375             


Lys Gln  Leu Glu Asp Ile Leu  Val Leu Ala Lys Gln  Phe His Glu 
    3380                 3385                 3390             


Thr Ala  Glu Pro Ile Ser Asp  Phe Leu Ser Val Thr  Glu Lys Lys 
    3395                 3400                 3405             


Leu Ala  Asn Ser Glu Pro Val  Gly Thr Gln Thr Ala  Lys Ile Gln 
    3410                 3415                 3420             


Gln Gln  Ile Ile Arg His Lys  Ala Leu Glu Glu Asp  Ile Glu Asn 
    3425                 3430                 3435             


His Ala  Thr Asp Val His Gln  Ala Val Lys Ile Gly  Gln Ser Leu 
    3440                 3445                 3450             


Ser Ser  Leu Thr Ser Pro Ala  Glu Gln Gly Val Leu  Ser Glu Lys 
    3455                 3460                 3465             


Ile Asp  Ser Leu Gln Ala Arg  Tyr Ser Glu Ile Gln  Asp Arg Cys 
    3470                 3475                 3480             


Cys Arg  Lys Ala Ala Leu Leu  Asp Gln Ala Leu Ser  Asn Ala Arg 
    3485                 3490                 3495             


Leu Phe  Gly Glu Asp Glu Val  Glu Val Leu Asn Trp  Leu Ala Glu 
    3500                 3505                 3510             


Val Glu  Asp Lys Leu Ser Ser  Val Phe Val Lys Asp  Phe Lys Gln 
    3515                 3520                 3525             


Asp Val  Leu His Arg Gln His  Ala Asp His Leu Ala  Leu Asn Glu 
    3530                 3535                 3540             


Glu Ile  Val Asn Arg Lys Lys  Asn Val Asp Gln Ala  Ile Lys Asn 
    3545                 3550                 3555             


Gly Gln  Ala Leu Leu Lys Gln  Thr Thr Gly Glu Glu  Val Leu Leu 
    3560                 3565                 3570             


Ile Gln  Glu Lys Leu Asp Gly  Ile Lys Thr Arg Tyr  Ala Asp Ile 
    3575                 3580                 3585             


Thr Val  Thr Ser Ser Lys Ala  Leu Arg Thr Leu Glu  Gln Ala Arg 
    3590                 3595                 3600             


Gln Leu  Ala Thr Lys Phe Gln  Ser Thr Tyr Glu Glu  Leu Thr Gly 
    3605                 3610                 3615             


Trp Leu  Arg Glu Val Glu Glu  Glu Leu Ala Thr Ser  Gly Gly Gln 
    3620                 3625                 3630             


Ser Pro  Thr Gly Glu Gln Ile  Pro Gln Phe Gln Gln  Arg Gln Lys 
    3635                 3640                 3645             


Glu Leu  Lys Lys Glu Val Met  Glu His Arg Leu Val  Leu Asp Thr 
    3650                 3655                 3660             


Val Asn  Glu Val Ser Arg Ala  Leu Leu Glu Leu Val  Pro Trp Arg 
    3665                 3670                 3675             


Ala Arg  Glu Gly Leu Asp Lys  Leu Val Ser Asp Ala  Asn Glu Gln 
    3680                 3685                 3690             


Tyr Lys  Leu Val Ser Asp Thr  Ile Gly Gln Arg Val  Asp Glu Ile 
    3695                 3700                 3705             


Asp Ala  Ala Ile Gln Arg Ser  Gln Gln Tyr Glu Gln  Ala Ala Asp 
    3710                 3715                 3720             


Ala Glu  Leu Ala Trp Val Ala  Glu Thr Lys Arg Lys  Leu Met Ala 
    3725                 3730                 3735             


Leu Gly  Pro Ile Arg Leu Glu  Gln Asp Gln Thr Thr  Ala Gln Leu 
    3740                 3745                 3750             


Gln Val  Gln Lys Ala Phe Ser  Ile Asp Ile Ile Arg  His Lys Asp 
    3755                 3760                 3765             


Ser Met  Asp Glu Leu Phe Ser  His Arg Ser Glu Ile  Phe Gly Thr 
    3770                 3775                 3780             


Cys Gly  Glu Glu Gln Lys Thr  Val Leu Gln Glu Lys  Thr Glu Ser 
    3785                 3790                 3795             


Leu Ile  Gln Gln Tyr Glu Ala  Ile Ser Leu Leu Asn  Ser Glu Arg 
    3800                 3805                 3810             


Tyr Ala  Arg Leu Glu Arg Ala  Gln Val Leu Val Asn  Gln Phe Trp 
    3815                 3820                 3825             


Glu Thr  Tyr Glu Glu Leu Ser  Pro Trp Ile Glu Glu  Thr Arg Ala 
    3830                 3835                 3840             


Leu Ile  Ala Gln Leu Pro Ser  Pro Ala Ile Asp His  Glu Gln Leu 
    3845                 3850                 3855             


Arg Gln  Gln Gln Glu Glu Met  Arg Gln Leu Arg Glu  Ser Ile Ala 
    3860                 3865                 3870             


Glu His  Lys Pro His Ile Asp  Lys Leu Leu Lys Ile  Gly Pro Gln 
    3875                 3880                 3885             


Leu Lys  Glu Leu Asn Pro Glu  Glu Gly Glu Met Val  Glu Glu Lys 
    3890                 3895                 3900             


Tyr Gln  Lys Ala Glu Asn Met  Tyr Ala Gln Ile Lys  Glu Glu Val 
    3905                 3910                 3915             


Arg Gln  Arg Ala Leu Ala Leu  Asp Glu Ala Val Ser  Gln Ser Thr 
    3920                 3925                 3930             


Gln Ile  Thr Glu Phe His Asp  Lys Ile Glu Pro Met  Leu Glu Thr 
    3935                 3940                 3945             


Leu Glu  Asn Leu Ser Ser Arg  Leu Arg Met Pro Pro  Leu Ile Pro 
    3950                 3955                 3960             


Ala Glu  Val Asp Lys Ile Arg  Glu Cys Ile Ser Asp  Asn Lys Ser 
    3965                 3970                 3975             


Ala Thr  Val Glu Leu Glu Lys  Leu Gln Pro Ser Phe  Glu Ala Leu 
    3980                 3985                 3990             


Lys Arg  Arg Gly Glu Glu Leu  Ile Gly Arg Ser Gln  Gly Ala Asp 
    3995                 4000                 4005             


Lys Asp  Leu Ala Ala Lys Glu  Ile Gln Asp Lys Leu  Asp Gln Met 
    4010                 4015                 4020             


Val Phe  Phe Trp Glu Asp Ile  Lys Ala Arg Ala Glu  Glu Arg Glu 
    4025                 4030                 4035             


Ile Lys  Phe Leu Asp Val Leu  Glu Leu Ala Glu Lys  Phe Trp Tyr 
    4040                 4045                 4050             


Asp Met  Ala Ala Leu Leu Thr  Thr Ile Lys Asp Thr  Gln Asp Ile 
    4055                 4060                 4065             


Val His  Asp Leu Glu Ser Pro  Gly Ile Asp Pro Ser  Ile Ile Lys 
    4070                 4075                 4080             


Gln Gln  Val Glu Ala Ala Glu  Thr Ile Lys Glu Glu  Thr Asp Gly 
    4085                 4090                 4095             


Leu His  Glu Glu Leu Glu Phe  Ile Arg Ile Leu Gly  Ala Asp Leu 
    4100                 4105                 4110             


Ile Phe  Ala Cys Gly Glu Thr  Glu Lys Pro Glu Val  Arg Lys Ser 
    4115                 4120                 4125             


Ile Asp  Glu Met Asn Asn Ala  Trp Glu Asn Leu Asn  Lys Thr Trp 
    4130                 4135                 4140             


Lys Glu  Arg Leu Glu Lys Leu  Glu Asp Ala Met Gln  Ala Ala Val 
    4145                 4150                 4155             


Gln Tyr  Gln Asp Thr Leu Gln  Ala Met Phe Asp Trp  Leu Asp Asn 
    4160                 4165                 4170             


Thr Val  Ile Lys Leu Cys Thr  Met Pro Pro Val Gly  Thr Asp Leu 
    4175                 4180                 4185             


Asn Thr  Val Lys Asp Gln Leu  Asn Glu Met Lys Glu  Phe Lys Val 
    4190                 4195                 4200             


Glu Val  Tyr Gln Gln Gln Ile  Glu Met Glu Lys Leu  Asn His Gln 
    4205                 4210                 4215             


Gly Glu  Leu Met Leu Lys Lys  Ala Thr Asp Glu Thr  Asp Arg Asp 
    4220                 4225                 4230             


Ile Ile  Arg Glu Pro Leu Thr  Glu Leu Lys His Leu  Trp Glu Asn 
    4235                 4240                 4245             


Leu Gly  Glu Lys Ile Ala His  Arg Gln His Lys Leu  Glu Gly Ala 
    4250                 4255                 4260             


Leu Leu  Ala Leu Gly Gln Phe  Gln His Ala Leu Glu  Glu Leu Met 
    4265                 4270                 4275             


Ser Trp  Leu Thr His Thr Glu  Glu Leu Leu Asp Ala  Gln Arg Pro 
    4280                 4285                 4290             


Ile Ser  Gly Asp Pro Lys Val  Ile Glu Val Glu Leu  Ala Lys His 
    4295                 4300                 4305             


His Val  Leu Lys Asn Asp Val  Leu Ala His Gln Ala  Thr Val Glu 
    4310                 4315                 4320             


Thr Val  Asn Lys Ala Gly Asn  Glu Leu Leu Glu Ser  Ser Ala Gly 
    4325                 4330                 4335             


Asp Asp  Ala Ser Ser Leu Arg  Ser Arg Leu Glu Ala  Met Asn Gln 
    4340                 4345                 4350             


Cys Trp  Glu Ser Val Leu Gln  Lys Thr Glu Glu Arg  Glu Gln Gln 
    4355                 4360                 4365             


Leu Gln  Ser Thr Leu Gln Gln  Ala Gln Gly Phe His  Ser Glu Ile 
    4370                 4375                 4380             


Glu Asp  Phe Leu Leu Glu Leu  Thr Arg Met Glu Ser  Gln Leu Ser 
    4385                 4390                 4395             


Ala Ser  Lys Pro Thr Gly Gly  Leu Pro Glu Thr Ala  Arg Glu Gln 
    4400                 4405                 4410             


Leu Asp  Thr His Met Glu Leu  Tyr Ser Gln Leu Lys  Ala Lys Glu 
    4415                 4420                 4425             


Glu Thr  Tyr Asn Gln Leu Leu  Asp Lys Gly Arg Leu  Met Leu Leu 
    4430                 4435                 4440             


Ser Arg  Asp Asp Ser Gly Ser  Gly Ser Lys Thr Glu  Gln Ser Val 
    4445                 4450                 4455             


Ala Leu  Leu Glu Gln Lys Trp  His Val Val Ser Ser  Lys Met Glu 
    4460                 4465                 4470             


Glu Arg  Lys Ser Lys Leu Glu  Glu Ala Leu Asn Leu  Ala Thr Glu 
    4475                 4480                 4485             


Phe Gln  Asn Ser Leu Gln Glu  Phe Ile Asn Trp Leu  Thr Leu Ala 
    4490                 4495                 4500             


Glu Gln  Ser Leu Asn Ile Ala  Ser Pro Pro Ser Leu  Ile Leu Asn 
    4505                 4510                 4515             


Thr Val  Leu Ser Gln Ile Glu  Glu His Lys Val Phe  Ala Asn Glu 
    4520                 4525                 4530             


Val Asn  Ala His Arg Asp Gln  Ile Ile Glu Leu Asp  Gln Thr Gly 
    4535                 4540                 4545             


Asn Gln  Leu Lys Phe Leu Ser  Gln Lys Gln Asp Val  Val Leu Ile 
    4550                 4555                 4560             


Lys Asn  Leu Leu Val Ser Val  Gln Ser Arg Trp Glu  Lys Val Val 
    4565                 4570                 4575             


Gln Arg  Ser Ile Glu Arg Gly  Arg Ser Leu Asp Asp  Ala Arg Lys 
    4580                 4585                 4590             


Arg Ala  Lys Gln Phe His Glu  Ala Trp Lys Lys Leu  Ile Asp Trp 
    4595                 4600                 4605             


Leu Glu  Asp Ala Glu Ser His  Leu Asp Ser Glu Leu  Glu Ile Ser 
    4610                 4615                 4620             


Asn Asp  Pro Asp Lys Ile Lys  Leu Gln Leu Ser Lys  His Lys Glu 
    4625                 4630                 4635             


Phe Gln  Lys Thr Leu Gly Gly  Lys Gln Pro Val Tyr  Asp Thr Thr 
    4640                 4645                 4650             


Ile Arg  Thr Gly Arg Ala Leu  Lys Glu Lys Thr Leu  Leu Pro Glu 
    4655                 4660                 4665             


Asp Ser  Gln Lys Leu Asp Asn  Phe Leu Gly Glu Val  Arg Asp Lys 
    4670                 4675                 4680             


Trp Asp  Thr Val Cys Gly Lys  Ser Val Glu Arg Gln  His Lys Leu 
    4685                 4690                 4695             


Glu Glu  Ala Leu Leu Phe Ser  Gly Gln Phe Met Asp  Ala Leu Gln 
    4700                 4705                 4710             


Ala Leu  Val Asp Trp Leu Tyr  Lys Val Glu Pro Gln  Leu Ala Glu 
    4715                 4720                 4725             


Asp Gln  Pro Val His Gly Asp  Leu Asp Leu Val Met  Asn Leu Met 
    4730                 4735                 4740             


Asp Ala  His Lys Val Phe Gln  Lys Glu Leu Gly Lys  Arg Thr Gly 
    4745                 4750                 4755             


Thr Val  Gln Val Leu Lys Arg  Ser Gly Arg Glu Leu  Ile Glu Asn 
    4760                 4765                 4770             


Ser Arg  Asp Asp Thr Thr Trp  Val Lys Gly Gln Leu  Gln Glu Leu 
    4775                 4780                 4785             


Ser Thr  Arg Trp Asp Thr Val  Cys Lys Leu Ser Val  Ser Lys Gln 
    4790                 4795                 4800             


Ser Arg  Leu Glu Gln Ala Leu  Lys Gln Ala Glu Val  Phe Arg Asp 
    4805                 4810                 4815             


Thr Val  His Met Leu Leu Glu  Trp Leu Ser Glu Ala  Glu Gln Thr 
    4820                 4825                 4830             


Leu Arg  Phe Arg Gly Ala Leu  Pro Asp Asp Thr Glu  Ala Leu Gln 
    4835                 4840                 4845             


Ser Leu  Ile Asp Thr His Lys  Glu Phe Met Lys Lys  Val Glu Glu 
    4850                 4855                 4860             


Lys Arg  Val Asp Val Asn Ser  Ala Val Ala Met Gly  Glu Val Ile 
    4865                 4870                 4875             


Leu Ala  Val Cys His Pro Asp  Cys Ile Thr Thr Ile  Lys His Trp 
    4880                 4885                 4890             


Ile Thr  Ile Ile Arg Ala Arg  Phe Glu Glu Val Leu  Thr Trp Ala 
    4895                 4900                 4905             


Lys Gln  His Gln Gln Arg Leu  Glu Thr Ala Leu Ser  Glu Leu Val 
    4910                 4915                 4920             


Ala Asn  Ala Glu Leu Leu Glu  Glu Leu Leu Ala Trp  Ile Gln Trp 
    4925                 4930                 4935             


Ala Glu  Thr Thr Leu Ile Gln  Arg Asp Gln Glu Pro  Ile Pro Gln 
    4940                 4945                 4950             


Asn Ile  Asp Arg Val Lys Ala  Leu Ile Ala Glu His  Gln Thr Phe 
    4955                 4960                 4965             


Met Glu  Glu Met Thr Arg Lys  Gln Pro Asp Val Asp  Arg Val Thr 
    4970                 4975                 4980             


Lys Thr  Tyr Lys Arg Lys Asn  Ile Glu Pro Thr His  Ala Pro Phe 
    4985                 4990                 4995             


Ile Glu  Lys Ser Arg Ser Gly  Gly Arg Lys Ser Leu  Ser Gln Pro 
    5000                 5005                 5010             


Thr Pro  Pro Pro Met Pro Ile  Leu Ser Gln Ser Glu  Ala Lys Asn 
    5015                 5020                 5025             


Pro Arg  Ile Asn Gln Leu Ser  Ala Arg Trp Gln Gln  Val Trp Leu 
    5030                 5035                 5040             


Leu Ala  Leu Glu Arg Gln Arg  Lys Leu Asn Asp Ala  Leu Asp Arg 
    5045                 5050                 5055             


Leu Glu  Glu Leu Lys Glu Phe  Ala Asn Phe Asp Phe  Asp Val Trp 
    5060                 5065                 5070             


Arg Lys  Lys Tyr Met Arg Trp  Met Asn His Lys Lys  Ser Arg Val 
    5075                 5080                 5085             


Met Asp  Phe Phe Arg Arg Ile  Asp Lys Asp Gln Asp  Gly Lys Ile 
    5090                 5095                 5100             


Thr Arg  Gln Glu Phe Ile Asp  Gly Ile Leu Ala Ser  Lys Phe Pro 
    5105                 5110                 5115             


Thr Thr  Lys Leu Glu Met Thr  Ala Val Ala Asp Ile  Phe Asp Arg 
    5120                 5125                 5130             


Asp Gly  Asp Gly Tyr Ile Asp  Tyr Tyr Glu Phe Val  Ala Ala Leu 
    5135                 5140                 5145             


His Pro  Asn Lys Asp Ala Tyr  Arg Pro Thr Thr Asp  Ala Asp Lys 
    5150                 5155                 5160             


Ile Glu  Asp Glu Val Thr Arg  Gln Val Ala Gln Cys  Lys Cys Ala 
    5165                 5170                 5175             


Lys Arg  Phe Gln Val Glu Gln  Ile Gly Glu Asn Lys  Tyr Arg Phe 
    5180                 5185                 5190             


Gly Asp  Ser Gln Gln Leu Arg  Leu Val Arg Ile Leu  Arg Ser Thr 
    5195                 5200                 5205             


Val Met  Val Arg Val Gly Gly  Gly Trp Met Ala Leu  Asp Glu Phe 
    5210                 5215                 5220             


Leu Val  Lys Asn Asp Pro Cys  Arg Ala Arg Gly Arg  Thr Asn Ile 
    5225                 5230                 5235             


Glu Leu  Arg Glu Lys Phe Ile  Leu Pro Glu Gly Ala  Ser Gln Gly 
    5240                 5245                 5250             


Met Thr  Pro Phe Arg Ser Arg  Gly Arg Arg Ser Lys  Pro Ser Ser 
    5255                 5260                 5265             


Arg Ala  Ala Ser Pro Thr Arg  Ser Ser Ser Ser Ala  Ser Gln Ser 
    5270                 5275                 5280             


Asn His  Ser Cys Thr Ser Met  Pro Ser Ser Pro Ala  Thr Pro Ala 
    5285                 5290                 5295             


Ser Gly  Thr Lys Val Ile Pro  Ser Ser Gly Ser Lys  Leu Lys Arg 
    5300                 5305                 5310             


Pro Thr  Pro Thr Phe His Ser  Ser Arg Thr Ser Leu  Ala Gly Asp 
    5315                 5320                 5325             


Thr Ser  Asn Ser Ser Ser Pro  Ala Ser Thr Gly Ala  Lys Thr Asn 
    5330                 5335                 5340             


Arg Ala  Asp Pro Lys Lys Ser  Ala Ser Arg Pro Gly  Ser Arg Ala 
    5345                 5350                 5355             


Gly Ser  Arg Ala Gly Ser Arg  Ala Ser Ser Arg Arg  Gly Ser Asp 
    5360                 5365                 5370             


Ala Ser  Asp Phe Asp Leu Leu  Glu Thr Gln Ser Ala  Cys Ser Asp 
    5375                 5380                 5385             


Thr Ser  Glu Ser Ser Ala Ala  Gly Gly Gln Gly Asn  Ser Arg Arg 
    5390                 5395                 5400             


Gly Leu  Asn Lys Pro Ser Lys  Ile Pro Thr Met Ser  Lys Lys Thr 
    5405                 5410                 5415             


Thr Thr  Ala Ser Pro Arg Thr  Pro Gly Pro Lys Arg  
    5420                 5425                 5430 


<210>  3
<211>  4153
<212>  DNA
<213>  Homo sapiens

<400>  3
aaacctccac gaaaataagg ctcaccttgc gtaaccacgt agtccttcgc cgcattgggg       60

caaaataatc ccttcatttt tgtgaaggta ccgtggaaaa tatttcattt ttcttctcac      120

cggagcaatt gtaaatgcta tgcggtaaga ggagttacct gtggaaaggt ggttaagaga      180

ttaggtaaag aaaaggaaag gacaccaaaa taaagtgctg cggaagaatt tttgtccagc      240

tgtgagacga cgagtgcgtg aagtgaaggc gattgagagg ggctgaggga attgtcctct      300

gtggaaggga ctttcttttg gccctaggcc ccttcctgcc cctgtcgtca gcagagtctc      360

tacaaggaag ataacggact gtaaaattct ataaagcaaa gctacacatc acttgacacc      420

atacaccatc ttggttacat aatgaagaga gatggaaaac ttgatgacta gctccaccct      480

accgcccctt tttgcagatg aagacggttc caaggagagt aatgatctgg ctaccactgg      540

gttaaatcac ccagaggttc catacagtag tggcgccaca tcatccacca acaatccaga      600

atttgtggag gatctctctc aaggtcagtt gcttcagagt gagtcttcaa atgcagcaga      660

aggcaatgaa cagaggcatg aagatgagca acgaagtaaa cgaggaggtt ggtccaaagg      720

aagaaagagg aagaaacctc ttcgagacag caatgcaccc aaatcccccc ttacaggata      780

tgttcggttc atgaatgagc gtcgagaaca acttcgagca aagagaccag aagtcccatt      840

tccagaaatc acaaggatgt taggcaatga atggagtaaa ctgcctcctg aggaaaaaca      900

gcgctacctt gatgaagcag acagagataa ggagcgttac atgaaggaac tggaacagta      960

tcagaaaaca gaggcctaca aggtcttcag taggaaaacc caggaccgtc agaaaggcaa     1020

atctcatagg caagatgcag cccggcaggc cactcatgat catgagaaag aaacagaggt     1080

aaaggaacgg tctgtttttg acatccctat atttacagag gaattcttga accatagcaa     1140

agctcgggaa gcagagctcc gccagcttcg caaatccaac atggagtttg aggagaggaa     1200

tgcagccctg caaaagcacg tggagagcat gcgcacagca gtggagaagc tggaggtgga     1260

tgtgatccag gagcggagcc gcaacacagt cttacagcag cacctggaga ccctgcggca     1320

ggtgctgacc agcagctttg ccagcatgcc cttgcctgga agtggagaga cacctacagt     1380

ggacaccatt gactcatata tgaacagact gcacagtatt attttagcta atccccaaga     1440

caatgaaaac ttcatagcta cagttcgaga agttgtgaac agactcgatc gttagggaat     1500

ggtcttagaa ctccaagatg ttccataagt gtttttactt gtgaggaatg agaagccatc     1560

catggaaatt tgaactgagt gggggcagag aaagagtgca gatccctttg cttgtgaaag     1620

aattatcagt gagtgaaagg ccatcacccc aggaagccaa atgagggagc agcaacatgt     1680

atatgagctt cctatggaat tgtccttatg tgaagctttg aaggtgtaca gccactctcc     1740

cgggtcttca ggttcctacc atttccattt ctgttaaagt ggatctgcat atcttcagct     1800

tactaggtga cccggatgct gacatctgct gctgcagaaa ggaagacttt tcattgtaat     1860

ttcgcttaga cccttttatc agtggagctc cagttttctt acctagctgt cactttttta     1920

aatgcctctg ggggttattt ttgctttcct tggcccccac caatttatac atctccattt     1980

tctgacctct ggactaactg gttgctcagc aaggttctga aggagagttt cttgcattgg     2040

acaggcccag tcttctccca tcattgccct gctgtgactc caaagaaagg agcttcttgc     2100

tgacagtgcc ctgtggagca aggctgtgtt tcctacccca cacggtgctc agtgggtgcc     2160

agccctcagt gtggctttgt gattgctgcc ctaaaggaga atgctctttc cttcctcact     2220

ggtactgcct gctgttttct aagcattgct cctgcacaga catggagtcc cagccccagc     2280

aaggctcttc tgttcccatc tgttgacaat gtcttgtgga gcatttttgc tgaggaaaag     2340

gtcacttgta aacagaggag aaagggaaag agtacaaagc cctaagttta ttgtaagtga     2400

aaactgaggg aattcctgtc ttctttagga gtaatgattc atagatctag ataggtggaa     2460

atatcattca aaatagtcac ttgagctcac aaaaaaagca aggaagaatt ctcatgtcct     2520

ttgtcttcct tctgtagcca ttaactgctg aatccatgtg aggaagacag gcttcccttc     2580

cttccccctc cttagtgatt ttttctttaa cagcataagt aaagaggact ttctggttca     2640

tttttgtttg ttttgttttg ttttgttttg tttacagatg aggtcttcct gtgttgccca     2700

ggctggagtg cggtggctat tcacagatgc tatcatagca cactacagcc tacaactctt     2760

gggctcaagc atcacgccta gcagtttctg gttcctttaa cagcaaaagg aaagagaggt     2820

tctgattctt acctcagggt tttttggttg ttcattgttt ttgtttttgt ttttgttttg     2880

acactgcaga gcacaaggct aaaggttaca gctgagatct ttggaaccaa aggcagagca     2940

agcagagccc gttgtctggg ccccacacca ctgcaggcag gtggatagaa gtgcggcccc     3000

tctcatagta tgcccataag tcagggcata gggcagaact acctgtcatg ttgctacacc     3060

atcctgtctt ctcagcatct ccttgcctgt tttctttatt agtccaaagg aaaacaacag     3120

caacaaaatc tgtttttaaa atgtcttata tgaacatata tcaaatatcc atgcgctgaa     3180

acccacatac catcacttgg caatttttta gaataagacc ccattattat ctattgctat     3240

aaacctagcc agttctcttg ctcttctgta ttttcctatt tccctgccat catctgctat     3300

ttctgccact tctcttagac tccttgtctg caaagcccaa gctagaactc actgtctatg     3360

gcagaaggac atccagagcc cattctggag ttttgttttt tccttctgcc agatgctttg     3420

tgtcctgtct tccttcctcc tcatatttct gtttctcatt tgtgttcagt tttgtgcagc     3480

attgctagca ctgcttttgt gaccagaaaa ggccataaca tggtccagga tcatcattct     3540

tctgactcta gatgggacac ttgacagtga cttgaaacat ttgcatattc aggaatgcat     3600

gagatttcaa gagagcctac agtatgaaat cattttcaca aaataagcag cttgcttctg     3660

aaatgctgtc tttcccagta gctactcacc tgcctctggt ggctgggatt cagatgccac     3720

aaaactgtca gtatctatag accaggtctg tgccacctcc tctctcctct gtgctcagtg     3780

aggaggcagt aaatgaagtt acaggctagc acaataccta actcatgttt cccagtacac     3840

ctgtagatat tactgtactt ttatgttctc aagaaataag ttgttgccta ttcagtgtta     3900

cagatttctt tgtttctttt taattaaaat acaagaagca gctgaggaaa gggagacaag     3960

gtattttatt tctgactgat tttagaaaaa acttgtgtac atgtgtttgg aactgttgaa     4020

atgccaagtt ttctgtataa gtgtttttgt aattaaactt tcagattttc tttgtttttt     4080

aagaagttga tgtgcttgtt tgacatttgt ctcattaaaa cttttctacg ttgaaaaaaa     4140

aaaaaaaaaa aaa                                                        4153


<210>  4
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Asn Leu Met Thr Ser Ser Thr Leu Pro Pro Leu Phe Ala Asp 
1               5                   10                  15      


Glu Asp Gly Ser Lys Glu Ser Asn Asp Leu Ala Thr Thr Gly Leu Asn 
            20                  25                  30          


His Pro Glu Val Pro Tyr Ser Ser Gly Ala Thr Ser Ser Thr Asn Asn 
        35                  40                  45              


Pro Glu Phe Val Glu Asp Leu Ser Gln Gly Gln Leu Leu Gln Ser Glu 
    50                  55                  60                  


Ser Ser Asn Ala Ala Glu Gly Asn Glu Gln Arg His Glu Asp Glu Gln 
65                  70                  75                  80  


Arg Ser Lys Arg Gly Gly Trp Ser Lys Gly Arg Lys Arg Lys Lys Pro 
                85                  90                  95      


Leu Arg Asp Ser Asn Ala Pro Lys Ser Pro Leu Thr Gly Tyr Val Arg 
            100                 105                 110         


Phe Met Asn Glu Arg Arg Glu Gln Leu Arg Ala Lys Arg Pro Glu Val 
        115                 120                 125             


Pro Phe Pro Glu Ile Thr Arg Met Leu Gly Asn Glu Trp Ser Lys Leu 
    130                 135                 140                 


Pro Pro Glu Glu Lys Gln Arg Tyr Leu Asp Glu Ala Asp Arg Asp Lys 
145                 150                 155                 160 


Glu Arg Tyr Met Lys Glu Leu Glu Gln Tyr Gln Lys Thr Glu Ala Tyr 
                165                 170                 175     


Lys Val Phe Ser Arg Lys Thr Gln Asp Arg Gln Lys Gly Lys Ser His 
            180                 185                 190         


Arg Gln Asp Ala Ala Arg Gln Ala Thr His Asp His Glu Lys Glu Thr 
        195                 200                 205             


Glu Val Lys Glu Arg Ser Val Phe Asp Ile Pro Ile Phe Thr Glu Glu 
    210                 215                 220                 


Phe Leu Asn His Ser Lys Ala Arg Glu Ala Glu Leu Arg Gln Leu Arg 
225                 230                 235                 240 


Lys Ser Asn Met Glu Phe Glu Glu Arg Asn Ala Ala Leu Gln Lys His 
                245                 250                 255     


Val Glu Ser Met Arg Thr Ala Val Glu Lys Leu Glu Val Asp Val Ile 
            260                 265                 270         


Gln Glu Arg Ser Arg Asn Thr Val Leu Gln Gln His Leu Glu Thr Leu 
        275                 280                 285             


Arg Gln Val Leu Thr Ser Ser Phe Ala Ser Met Pro Leu Pro Gly Ser 
    290                 295                 300                 


Gly Glu Thr Pro Thr Val Asp Thr Ile Asp Ser Tyr Met Asn Arg Leu 
305                 310                 315                 320 


His Ser Ile Ile Leu Ala Asn Pro Gln Asp Asn Glu Asn Phe Ile Ala 
                325                 330                 335     


Thr Val Arg Glu Val Val Asn Arg Leu Asp Arg 
            340                 345         


<210>  5
<211>  2125
<212>  DNA
<213>  Homo sapiens

<400>  5
aatccgtggt ctggtacagg tttcagggca aagcggccat gcgttccggg ggccgcgggc       60

gaccccgcct gcggctgggg gaacgtggcc tcatggagcc actcttgccg ccgaagcgcc      120

gcctgctacc gcgggttcgg ctcttgcctc tgttgctggc gctggccgtg ggctcggcgt      180

tctacaccat ttggagcggc tggcaccgca ggactgagga gctgccgctg ggccgggagc      240

tgcgggtccc attgatcgga agcctccccg aagcccggct gcggagggtg gtgggacaac      300

tggatccaca gcgtctctgg agcacttatc tgcgccccct gctggttgtg cgaaccccgg      360

gcagcccggg aaatctccaa gtcagaaagt tcctggaggc cacgctgcgg tccctgacag      420

caggttggca cgtggagctg gatcccttca cagcctcaac acccctgggg ccagtggact      480

ttggcaatgt ggtggccaca ctggacccaa gggctgcccg tcacctcacc cttgcctgcc      540

attatgactc gaagctcttc ccacccggat cgaccccctt tgtaggggcc acggattcgg      600

ctgtgccctg tgccctgctg ctggagctgg cccaagcact tgacctggag ctgagcaggg      660

ccaaaaaaca ggcagccccg gtgaccctgc aactgctctt cttggatggt gaagaggcgc      720

tgaaggagtg gggacccaag gactcccttt acggttcccg gcacctggcc cagctcatgg      780

agtctatacc tcacagcccc ggccccacca ggatccaggc tattgagctc tttatgcttc      840

ttgatctcct gggagccccc aatcccacct tctacagcca cttccctcgc acggtccgct      900

ggttccatcg gctgaggagc attgagaagc gtctgcaccg tttgaacctg ctgcagtctc      960

atccccagga agtgatgtac ttccaacccg gggagccctt tggctctgtg gaagacgacc     1020

acatcccctt cctccgcaga ggggtacccg tgctccatct catctccacg cccttccctg     1080

ctgtctggca cacccctgcg gacaccgagg tcaatctcca cccacccacg gtacacaact     1140

tgtgccgcat tctcgctgtg ttcctggctg aatacctggg gctctagcgt gcttggccaa     1200

tgactgtgga gaggactgtg agagagaagg tcccagcggg ggccagtgaa gctcaggcag     1260

gatctgccta gggtgtgctg gtttgtcctt ttcatacctt tgtctcctaa ttgtgctaca     1320

attggaagac cttctttctt ttgattgtct caagctgcca cccttcaagg acagggaaga     1380

gaccactgtg ggatgacagc cagaggaata agaacttgct ccctccccag aggtaaacac     1440

ttggtccaaa ggtttgcagg gaccaaatac tgttcttttt ttttttgaga cggagtctca     1500

ctgtgttgcc caggctggag tgcagtggtg cgatctcggc tcactgcaaa ctccgcctcc     1560

tgggttcacg ccattctcct gcctcagcct cccaagtagc tgggactaca ggtgcccgcc     1620

accacgctgg ctaatttttt gtatttttag tagagacggg gtttcaccgt gttagccagg     1680

atggtctcga tctcctgacc ttgtaatccg ccagcctcgg cctcccaaag tgctgggatt     1740

acaggtgtga gccaccgcac ctggcaaaat gctgttcttt aagtcagcga actgaaaaag     1800

taaaagactg ctgggtgtgg tggctcacac ctgtaatccc aacactttga gaggctgagg     1860

gggaaggatc acccgaggtc aggagtttga gaccagcctg gtcaacatgg cgaaaccctg     1920

tctctactaa aaatacaata attagctggg catggtggtg ggcgcctgta atctcagctg     1980

cttgggaggc tgaggcagga gaatcacttg tacgcaggag gcggaggttg cagtgagcca     2040

agatcacacc actgcactcc agcctgggca acagagcgag actccatctc aataaataaa     2100

taaataaata aatatttttt aaaaa                                           2125


<210>  6
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ser Gly Gly Arg Gly Arg Pro Arg Leu Arg Leu Gly Glu Arg 
1               5                   10                  15      


Gly Leu Met Glu Pro Leu Leu Pro Pro Lys Arg Arg Leu Leu Pro Arg 
            20                  25                  30          


Val Arg Leu Leu Pro Leu Leu Leu Ala Leu Ala Val Gly Ser Ala Phe 
        35                  40                  45              


Tyr Thr Ile Trp Ser Gly Trp His Arg Arg Thr Glu Glu Leu Pro Leu 
    50                  55                  60                  


Gly Arg Glu Leu Arg Val Pro Leu Ile Gly Ser Leu Pro Glu Ala Arg 
65                  70                  75                  80  


Leu Arg Arg Val Val Gly Gln Leu Asp Pro Gln Arg Leu Trp Ser Thr 
                85                  90                  95      


Tyr Leu Arg Pro Leu Leu Val Val Arg Thr Pro Gly Ser Pro Gly Asn 
            100                 105                 110         


Leu Gln Val Arg Lys Phe Leu Glu Ala Thr Leu Arg Ser Leu Thr Ala 
        115                 120                 125             


Gly Trp His Val Glu Leu Asp Pro Phe Thr Ala Ser Thr Pro Leu Gly 
    130                 135                 140                 


Pro Val Asp Phe Gly Asn Val Val Ala Thr Leu Asp Pro Arg Ala Ala 
145                 150                 155                 160 


Arg His Leu Thr Leu Ala Cys His Tyr Asp Ser Lys Leu Phe Pro Pro 
                165                 170                 175     


Gly Ser Thr Pro Phe Val Gly Ala Thr Asp Ser Ala Val Pro Cys Ala 
            180                 185                 190         


Leu Leu Leu Glu Leu Ala Gln Ala Leu Asp Leu Glu Leu Ser Arg Ala 
        195                 200                 205             


Lys Lys Gln Ala Ala Pro Val Thr Leu Gln Leu Leu Phe Leu Asp Gly 
    210                 215                 220                 


Glu Glu Ala Leu Lys Glu Trp Gly Pro Lys Asp Ser Leu Tyr Gly Ser 
225                 230                 235                 240 


Arg His Leu Ala Gln Leu Met Glu Ser Ile Pro His Ser Pro Gly Pro 
                245                 250                 255     


Thr Arg Ile Gln Ala Ile Glu Leu Phe Met Leu Leu Asp Leu Leu Gly 
            260                 265                 270         


Ala Pro Asn Pro Thr Phe Tyr Ser His Phe Pro Arg Thr Val Arg Trp 
        275                 280                 285             


Phe His Arg Leu Arg Ser Ile Glu Lys Arg Leu His Arg Leu Asn Leu 
    290                 295                 300                 


Leu Gln Ser His Pro Gln Glu Val Met Tyr Phe Gln Pro Gly Glu Pro 
305                 310                 315                 320 


Phe Gly Ser Val Glu Asp Asp His Ile Pro Phe Leu Arg Arg Gly Val 
                325                 330                 335     


Pro Val Leu His Leu Ile Ser Thr Pro Phe Pro Ala Val Trp His Thr 
            340                 345                 350         


Pro Ala Asp Thr Glu Val Asn Leu His Pro Pro Thr Val His Asn Leu 
        355                 360                 365             


Cys Arg Ile Leu Ala Val Phe Leu Ala Glu Tyr Leu Gly Leu 
    370                 375                 380         


<210>  7
<211>  5476
<212>  DNA
<213>  Homo sapiens

<400>  7
aagctcttga gctcctctac ctcttagaaa gcacaattga atcagatatc atatgaaaga       60

catacacact tcatgtaatg ctacctgcaa gtctccctag aaaagcagtt tttgtaggtg      120

aaaacaatga agccaggtaa tattgcaagg aggctgtaat tttagcagac ctaccaacaa      180

cactgatgta ggaagctcat tattttaatt tctggagcct tttaattttt tctttagaaa      240

gtgtataaat aattgcagtg ctgctttgct tccaaaactg ggcagtgagt tcaacaacaa      300

cgacaacaac agccgcagct catcctggcc gtcatggagt ttcttgaaag aacgtatctt      360

gtgaatgata aagctgccaa gatgtatgct ttcacactag aaagtgtgga actccaacag      420

aaaccggtga ataaagatca gtgtcccaga gagagaccag aggagctgga gtcaggaggc      480

atgtaccact gccacagtgg ctccaagccc acagaaaagg gggcgaatga gtacgcctat      540

gccaagtgga aactctgttc tgcttcagca atatgcttca ttttcatgat tgcagaggtc      600

gtgggtgggc acattgctgg gagtcttgct gttgtcacag atgctgccca cctcttaatt      660

gacctgacca gtttcctgct cagtctcttc tccctgtggt tgtcatcgaa gcctccctct      720

aagcggctga catttggatg gcaccgagca gagatccttg gtgccctgct ctccatcctg      780

tgcatctggg tggtgactgg cgtgctagtg tacctggcat gtgagcgcct gctgtatcct      840

gattaccaga tccaggcgac tgtgatgatc atcgtttcca gctgcgcagt ggcggccaac      900

attgtactaa ctgtggtttt gcaccagaga tgccttggcc acaatcacaa ggaagtacaa      960

gccaatgcca gcgtcagagc tgcttttgtg catgcccttg gagatctatt tcagagtatc     1020

agtgtgctaa ttagtgcact tattatctac tttaagccag agtataaaat agccgaccca     1080

atctgcacat tcatcttttc catcctggtc ttggccagca ccatcactat cttaaaggac     1140

ttctccatct tactcatgga aggtgtgcca aagagcctga attacagtgg tgtgaaagag     1200

cttattttag cagtcgacgg ggtgctgtct gtgcacagcc tgcacatctg gtctctaaca     1260

atgaatcaag taattctctc agctcatgtt gctacagcag ccagccggga cagccaagtg     1320

gttcggagag aaattgctaa agcccttagc aaaagcttta cgatgcactc actcaccatt     1380

cagatggaat ctccagttga ccaggacccc gactgccttt tctgtgaaga cccctgtgac     1440

tagctcagtc acaccgtcag tttcccaaat ttgacaggcc accttcaaac atgctgctat     1500

gcagtttctg catcatagaa aataaggaac caaaggaaga aattcatgtc atggtgcaat     1560

gcacatttta tctatttatt tagttccatt caccatgaag gaagaggcac tgagatccat     1620

caatcaattg gattatatac tgatcagtag ctgtgttcaa ttgcaggaat gtgtatatag     1680

attattcctg agtggagccg aagtaacagc tgtttgtaac tatcggcaat accaaattca     1740

tctcccttcc aataatgcat cttgagaaca cataggtaaa tttgaactca ggaaagtctt     1800

actagaaatc agtggaaggg acaaatagtc acaaaatttt accaaaacat tagaaacaaa     1860

aaataaggag agccaagtca ggaataaaag tgactctgta tgctaacgcc acattagaac     1920

ttggttctct caccaagctg taatgtgatt tttttttcta ctctgaattg gaaatatgta     1980

tgaatataca gagaagtgct tacaactaat ttttatttac ttgtcacatt ttggcaataa     2040

atccctctta tttctaaatt ctaacttgtt tatttcaaaa ctttatataa tcactgttca     2100

aaaggaaata ttttcaccta ccagagtgct taaacactgg caccagccaa agaatgtggt     2160

tgtagagacc cagaagtctt caagaacagc cgacaaaaac attcgagttg accccaccaa     2220

gttgttgcca cagataattt agatatttac ctgcaagaag gaataaagca gatgcaacca     2280

attcattcag tccacgagca tgatgtgagc actgctttgt gctagacatt gggcttagca     2340

ttgaaactat aaagaggaat cagacgcagc aagtgcttct gtgttctggt agcaactcaa     2400

cactatctgt ggagagtaaa ctgaagatgt gcaggccaac attctggaaa tcctatgtca     2460

atgggtttgg tttggaacct ggacttctgc atttttaaaa gttacccaga gatgcttcta     2520

aagatgagcc atagtctaga agattgtcaa ccacaggagt tcattgagtg ggacagctag     2580

acacatacat tggcagctac aatagtatca tgaattgcaa tgatgtagtg gggtataaaa     2640

ggaaagcgat ggatattgcc ggatgggcat ggccagtgat gtttcacgtc attgaggtga     2700

cagctctgct ggactttgaa ttacatatgg aggctctcca ggaagacgaa gaagagaagg     2760

acattctagg caaaaagaag actaggcaca aggcacactt atgtttgtct gttagctttt     2820

agttgaaaaa gcaaaataca tgatgcaaag aaacctctcc acgctgtgat ttttaaaact     2880

acatactttt tgcaacttta tggttatgag tattgtagag aacaggagat aggtcttaga     2940

tgatttttat gttgttgtca gactctagca aggtactaga aacctagcag gcattaataa     3000

ttgttgaggc aatgactctg aggctatatc tgggccttgt cattatttat catttatatt     3060

tgtatttttt tctgaaattt gagggccaag aaaacattga ctttgactga ggaggtcaca     3120

tctgtgccat ctctgcaaat caatcagcac cactgaaata actacttagc attctgctga     3180

gctttccctg ctcagtagag acaaatatac tcatccccca cctcagtgag cttgtttagg     3240

caaccaggat tagagctgct caggttccca acgtctcctg ccacatcggg ttctcaaaat     3300

ggaaagaatg gtttatgcca aatcactttt cctgtctgaa ggaccactga atggttttgt     3360

ttttccatat tttgcatagg acgccctaaa gactaggtga cttggcaaac acacaagtgt     3420

tagtataatt ctttgcttct gcttcttttt gaaaatcatg tttagatttg attttaagtc     3480

agaaattcac tgaatgtcag gtaatcatta tggagggaga tttgtgtgtc aaccaaagta     3540

attgtcccat ggccccaggg tatttctgtt gtttccctga aattctgctt ttttagtcag     3600

ctagattgaa aactctgaac agtagatgtt tatatggcaa aatgcaagac aatctacaag     3660

ggagatttta aggattttga gatgaaaaaa cagatgctac tcaggggctt tatgaaccat     3720

ccatcaattc tgaagttctg actctcccat taccctttcc ctggtgtggt cagaactcca     3780

ggtcactgga agttagtgga atcatgtagt tgaattcttt acttcaagac attgtattct     3840

ctccagctat caaaacatta atgatctttt atgtcttttt tttgttattg ttatacttta     3900

agttctgggg tacatgtgcg gaacatgtag gtttgttaca taggtataca tgtgccatgg     3960

tggtttgctg cactcatcaa cctgtcatct acattctttt atgtctgtct ttcaaagcaa     4020

cactctgttc ttctgagtag tgaaatcagg tcaactttac caccagcctc catttttaat     4080

atgcttcacc atcatccagc acctacttaa gatttatcta gggctctgtg gtgatgttag     4140

gacccataaa agaaatttat gccttccata tgtttggtta cagatgggaa atgggaatgt     4200

tgaaggacat gaaagaaagg atgtttacac attaagcatc agttctgaag ctagattgtc     4260

tgagtttgaa tcttagctct tccctttatt agctctgtga cctcgagcta gttacttaaa     4320

tgctctgatc ctctatttcc tgatcagtga aacctcccta ttcaaatgtg tgagagttta     4380

ataaattagg acacttaaaa atgttggagc agtgcatagc atgtagtgtt cagtacatgt     4440

taaatgttgt tttttattat gtacaaacat gagtgggcac agaattttaa atcatctcaa     4500

cttttgagaa attttgagtt atcaacaccg ttcccacaag acagtggcaa aattattggt     4560

gagaattaaa cagctgtttc tcagaggaag caatggaggc ttgctgggat aaaggcattt     4620

actgagaggc tgttacctag tgagagtgat gaattaatta aaatagtcga atccctttct     4680

gactgtctct gaaagcttcc gcttttatct ttgaagagca gaattgtcac tccaaggaca     4740

tttattaata aaaagaacaa ctgtccagtg caatgaaggc aaagtcatag gtctcccaag     4800

tcttacccca ttcctgtgaa atatcaagtt cttggctttt ctctgtcatg tagcctcaac     4860

tttctctgac cgggtgcatt tctttctctg gtttctaaat tgccagtggc aaatttggat     4920

cacttactta atatctgtta aattttgtga cccaacaaag tcttttagca ctgtggtgtc     4980

aaaaagaaaa acacctccca ggcatataca ttttatagat tcctggagaa tgttgctctc     5040

cagctccatc cccacccaat gaaatatgat ccagagagtc ttgcaaagag acaagcctca     5100

ttttccacaa ttagctctaa agtgcctcca ggaaatgatt ttctcagctc atctctctgt     5160

attccctgtt ttggatcaca gggcaatctg tttaaatgac taattacaga aatcattaaa     5220

ggcaccaagc aaatgtcatc tctgaataca cacatcccaa gctttacaaa tcctgcctgg     5280

cttgacagtg atgaggccac ttaacagtcc agcgcaggcg gatgttaaaa aaaataaaaa     5340

ggtgaccatc tgcggtttag ttttttaact ttctgatttc acacttaacg tctgtcattc     5400

tgttactggg cacctgttta aattctattt taaaatgtta atgtgtgttg tttaaaataa     5460

aatcaagaaa gagaga                                                     5476


<210>  8
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Phe Leu Glu Arg Thr Tyr Leu Val Asn Asp Lys Ala Ala Lys 
1               5                   10                  15      


Met Tyr Ala Phe Thr Leu Glu Ser Val Glu Leu Gln Gln Lys Pro Val 
            20                  25                  30          


Asn Lys Asp Gln Cys Pro Arg Glu Arg Pro Glu Glu Leu Glu Ser Gly 
        35                  40                  45              


Gly Met Tyr His Cys His Ser Gly Ser Lys Pro Thr Glu Lys Gly Ala 
    50                  55                  60                  


Asn Glu Tyr Ala Tyr Ala Lys Trp Lys Leu Cys Ser Ala Ser Ala Ile 
65                  70                  75                  80  


Cys Phe Ile Phe Met Ile Ala Glu Val Val Gly Gly His Ile Ala Gly 
                85                  90                  95      


Ser Leu Ala Val Val Thr Asp Ala Ala His Leu Leu Ile Asp Leu Thr 
            100                 105                 110         


Ser Phe Leu Leu Ser Leu Phe Ser Leu Trp Leu Ser Ser Lys Pro Pro 
        115                 120                 125             


Ser Lys Arg Leu Thr Phe Gly Trp His Arg Ala Glu Ile Leu Gly Ala 
    130                 135                 140                 


Leu Leu Ser Ile Leu Cys Ile Trp Val Val Thr Gly Val Leu Val Tyr 
145                 150                 155                 160 


Leu Ala Cys Glu Arg Leu Leu Tyr Pro Asp Tyr Gln Ile Gln Ala Thr 
                165                 170                 175     


Val Met Ile Ile Val Ser Ser Cys Ala Val Ala Ala Asn Ile Val Leu 
            180                 185                 190         


Thr Val Val Leu His Gln Arg Cys Leu Gly His Asn His Lys Glu Val 
        195                 200                 205             


Gln Ala Asn Ala Ser Val Arg Ala Ala Phe Val His Ala Leu Gly Asp 
    210                 215                 220                 


Leu Phe Gln Ser Ile Ser Val Leu Ile Ser Ala Leu Ile Ile Tyr Phe 
225                 230                 235                 240 


Lys Pro Glu Tyr Lys Ile Ala Asp Pro Ile Cys Thr Phe Ile Phe Ser 
                245                 250                 255     


Ile Leu Val Leu Ala Ser Thr Ile Thr Ile Leu Lys Asp Phe Ser Ile 
            260                 265                 270         


Leu Leu Met Glu Gly Val Pro Lys Ser Leu Asn Tyr Ser Gly Val Lys 
        275                 280                 285             


Glu Leu Ile Leu Ala Val Asp Gly Val Leu Ser Val His Ser Leu His 
    290                 295                 300                 


Ile Trp Ser Leu Thr Met Asn Gln Val Ile Leu Ser Ala His Val Ala 
305                 310                 315                 320 


Thr Ala Ala Ser Arg Asp Ser Gln Val Val Arg Arg Glu Ile Ala Lys 
                325                 330                 335     


Ala Leu Ser Lys Ser Phe Thr Met His Ser Leu Thr Ile Gln Met Glu 
            340                 345                 350         


Ser Pro Val Asp Gln Asp Pro Asp Cys Leu Phe Cys Glu Asp Pro Cys 
        355                 360                 365             


Asp 
    


<210>  9
<211>  2300
<212>  DNA
<213>  Homo sapiens

<400>  9
agagcggagc ggtgggccgg gggctggagg acaggtttgt gcgctggacg caagcaccag       60

gcgcagcctc gctcgccgag acccggccag aacgtgttac gagtcagttt ttagtgaaaa      120

aacattgagc taggagccaa gacccatctc ttcactattt tggtattgtg caagtcatct      180

tacctctctg gatctcagtt gtctcatctg taaaaaggag ataaaaatta tttacctgcc      240

tgaacatgag gtggaggacc atcctgctac agtattgctt tctcttgatt acatgtttac      300

ttactgctct tgaagctgtg cctattgaca tagacaagac aaaagtacaa aatattcacc      360

ctgtggaaag tgcgaagata gaaccaccag atactggact ttattatgat gaatatctca      420

agcaagtgat tgatgtgctg gaaacagata aacacttcag agaaaagctc cagaaagcag      480

acatagagga aataaagagt gggaggctaa gcaaagaact ggatttagta agtcaccatg      540

tgaggacaaa acttgatgaa ctgaaaaggc aagaagtagg aaggttaaga atgttaatta      600

aagctaagtt ggattccctt caagatatag gcatggacca ccaagctctt ctaaaacaat      660

ttgatcacct aaaccacctg aatcctgaca agtttgaatc cacagattta gatatgctaa      720

tcaaagcggc aacaagtgat ctggaacact atgacaagac tcgtcatgaa gaatttaaaa      780

aatatgaaat gatgaaggaa catgaaagga gagaatattt aaaaacattg aatgaagaaa      840

agagaaaaga agaagagtct aaatttgaag aaatgaagaa aaagcatgaa aatcacccta      900

aagttaatca cccaggaagc aaagatcaac taaaagaggt atgggaagag actgatggat      960

tggatcctaa tgactttgac cccaagacat ttttcaaatt acatgatgtc aatagtgatg     1020

gattcctgga tgaacaagaa ttagaagccc tatttactaa agagttggag aaagtatatg     1080

accctaaaaa tgaagaggat gatatggtag aaatggaaga agaaaggctt agaatgaggg     1140

aacatgtaat gaatgaggtt gatactaaca aagacagatt ggtgactctg gaggagtttt     1200

tgaaagccac agaaaaaaaa gaattcttgg agccagatag ctgggagaca ttagatcagc     1260

aacagttctt cacagaggaa gaactaaaag aatatgaaaa tattattgct ttacaagaaa     1320

atgaacttaa gaagaaggca gatgagcttc agaaacaaaa agaagagcta caacgtcagc     1380

atgatcaact ggaggctcag aagctggaat atcatcaggt catacagcag atggaacaaa     1440

aaaaattaca acaaggaatt cctccatcag ggccagctgg agaattgaag tttgagccac     1500

acatttaaag tctgaagtcc accagaactt ggaagaaagc tgttaactca acatctattt     1560

catcttttta gctcccttcc tttttctctg ctcaataaat attttaaaag catatttgaa     1620

ataaagggag atacttttta aatgaaaaca ctttttttgg gacacagata ttaaaggatt     1680

gaagtttatc agaaccagga agaaaacaaa ctcactgtct gctctctgct ctcacattca     1740

cacggctctt ttatttattt ttttgttctc ctttaatgat ttaattaagt ggctttatgc     1800

cataatttag tgaaactatt aggaactatt taagtgagaa aactctgcct cttgctttta     1860

aattagattg ctctcactta ctcgtaaaca taggtattct tttatgggtg cttatcattc     1920

cttctttcaa taaatgtctg tttgatatta acaattctgg aaaggccaca gtatttccct     1980

gtgtttcctg gtaacgtttt tctagttttg gcaacctcaa ctgctagaaa ttcttcacct     2040

gaatcacttt tgctaccact tcaggtcatt tttcattctt ttttattttg ctctatactt     2100

tatcatttaa gattaggtta tgttacatat aacagaaaaa acaaagataa cagtggttta     2160

aactaaatag gagtttttct tcttacataa gtctagaagt aggtggtgtc caggttccta     2220

tctttctgct ctgctatcct cagtgcatga tttttatcct cagattacct cactctcact     2280

gttcaagttt gctcctggag                                                 2300


<210>  10
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Trp Arg Thr Ile Leu Leu Gln Tyr Cys Phe Leu Leu Ile Thr 
1               5                   10                  15      


Cys Leu Leu Thr Ala Leu Glu Ala Val Pro Ile Asp Ile Asp Lys Thr 
            20                  25                  30          


Lys Val Gln Asn Ile His Pro Val Glu Ser Ala Lys Ile Glu Pro Pro 
        35                  40                  45              


Asp Thr Gly Leu Tyr Tyr Asp Glu Tyr Leu Lys Gln Val Ile Asp Val 
    50                  55                  60                  


Leu Glu Thr Asp Lys His Phe Arg Glu Lys Leu Gln Lys Ala Asp Ile 
65                  70                  75                  80  


Glu Glu Ile Lys Ser Gly Arg Leu Ser Lys Glu Leu Asp Leu Val Ser 
                85                  90                  95      


His His Val Arg Thr Lys Leu Asp Glu Leu Lys Arg Gln Glu Val Gly 
            100                 105                 110         


Arg Leu Arg Met Leu Ile Lys Ala Lys Leu Asp Ser Leu Gln Asp Ile 
        115                 120                 125             


Gly Met Asp His Gln Ala Leu Leu Lys Gln Phe Asp His Leu Asn His 
    130                 135                 140                 


Leu Asn Pro Asp Lys Phe Glu Ser Thr Asp Leu Asp Met Leu Ile Lys 
145                 150                 155                 160 


Ala Ala Thr Ser Asp Leu Glu His Tyr Asp Lys Thr Arg His Glu Glu 
                165                 170                 175     


Phe Lys Lys Tyr Glu Met Met Lys Glu His Glu Arg Arg Glu Tyr Leu 
            180                 185                 190         


Lys Thr Leu Asn Glu Glu Lys Arg Lys Glu Glu Glu Ser Lys Phe Glu 
        195                 200                 205             


Glu Met Lys Lys Lys His Glu Asn His Pro Lys Val Asn His Pro Gly 
    210                 215                 220                 


Ser Lys Asp Gln Leu Lys Glu Val Trp Glu Glu Thr Asp Gly Leu Asp 
225                 230                 235                 240 


Pro Asn Asp Phe Asp Pro Lys Thr Phe Phe Lys Leu His Asp Val Asn 
                245                 250                 255     


Ser Asp Gly Phe Leu Asp Glu Gln Glu Leu Glu Ala Leu Phe Thr Lys 
            260                 265                 270         


Glu Leu Glu Lys Val Tyr Asp Pro Lys Asn Glu Glu Asp Asp Met Val 
        275                 280                 285             


Glu Met Glu Glu Glu Arg Leu Arg Met Arg Glu His Val Met Asn Glu 
    290                 295                 300                 


Val Asp Thr Asn Lys Asp Arg Leu Val Thr Leu Glu Glu Phe Leu Lys 
305                 310                 315                 320 


Ala Thr Glu Lys Lys Glu Phe Leu Glu Pro Asp Ser Trp Glu Thr Leu 
                325                 330                 335     


Asp Gln Gln Gln Phe Phe Thr Glu Glu Glu Leu Lys Glu Tyr Glu Asn 
            340                 345                 350         


Ile Ile Ala Leu Gln Glu Asn Glu Leu Lys Lys Lys Ala Asp Glu Leu 
        355                 360                 365             


Gln Lys Gln Lys Glu Glu Leu Gln Arg Gln His Asp Gln Leu Glu Ala 
    370                 375                 380                 


Gln Lys Leu Glu Tyr His Gln Val Ile Gln Gln Met Glu Gln Lys Lys 
385                 390                 395                 400 


Leu Gln Gln Gly Ile Pro Pro Ser Gly Pro Ala Gly Glu Leu Lys Phe 
                405                 410                 415     


Glu Pro His Ile 
            420 


<210>  11
<211>  9661
<212>  DNA
<213>  Homo sapiens

<400>  11
ggatgaagag taacgccatt accgccggag ccgccgagag ccttagccga cggaaactgg       60

acactggacc ggcagcgcca tgagactcct cccccgcttg ctgctgcttc tcttactcgt      120

gttccctgcc actgtcttgt tccgaggcgg ccccagaggc ttgttagcag tggcacaaga      180

tcttacagag gatgaagaaa cagtagaaga ttccataatt gaggatgaag atgatgaagc      240

cgaggtagaa gaagatgaac ccacagattt ggtagaagat aaagaggaag aagatgtgtc      300

tggtgaacct gaagcttcac cgagtgcaga tacaactata ctgtttgtaa aaggagaaga      360

ttttccagca aataacattg tgaagttcct ggtaggcttt accaacaagg gtacagaaga      420

ttttattgtt gaatccttag atgcctcatt ccgttatcct caggactacc agttttatat      480

ccagaatttc acagctcttc ctctgaacac tgtagtgcca ccccagagac aggcaacttt      540

tgagtactct ttcattcctg cagagcccat gggcggacga ccatttggtt tggtcatcaa      600

tctgaactac aaagatttga acggcaatgt attccaagat gcagtcttca atcaaacagt      660

tacagttatt gaaagagagg atgggttaga tggagaaaca atctttatgt atatgttcct      720

tgctggtctt gggcttctgg ttattgttgg ccttcatcaa ctcctagaat ctagaaagcg      780

taagagaccc atacagaaag tagaaatggg tacatcaagt cagaatgatg ttgacatgag      840

ttggattcct caggaaacat tgaatcaaat caataaagct tcaccaagaa ggttgcccag      900

gaaacgggca cagaagagat cagtgggatc tgatgagtaa atgttccttt gtgcaacaat      960

tcggtcttta cttaacctgc cctaatattt ttcggcctga tgggaattag tgcagagaag     1020

ccatgtcacc atagaaggca actcctactt gtgtgtggac tgagcaatca gagtctgtgg     1080

cgataatatt gctgaaaatg cactgcattc atttttctaa agtaacaaat ttggtttttt     1140

tttaaaccat taaaatctat gtgtgtgcgt gtgtatgtat gtgagcagtt ggtcttacca     1200

gaatcattgt tgaactacct gaaacaagtc tttagaatac taaatataat gctgttgtct     1260

cttccttttt gacattttct gattttttcc cccaaaactc agttaatatt tacccactat     1320

gattattgat gtcctgcctt gaacagtttt aaagaaaaca atttttggaa tagctcaaat     1380

ttcaattgat ggcacaaatc agcattttgt tgttgttact gtattacaat tagtattcta     1440

aaggcagaag cagaagtagc tgctttttag caatagaatt gtttcagtat tttgctgctg     1500

tttaatgcgc atcttcagaa aacttcccag tggcttcaag gaatttgggg atctctctgg     1560

caacaaattg tgaaacatga aatttctgct gactttaata tatgaaacct aatcctaccc     1620

ccttttttaa caaaaagaaa ctagtacatt tgtgaaaatt gtgttgtgtt gtccattgtt     1680

gctctagttc tgacccagag gtagctctgg agtgatttta gacctactca ctcagttgtg     1740

tgtaggtttt tttgttttgt tttgagagag aatttttctc tccttaatag aagcatcctt     1800

tttaaagaga agttgccttg gtccacacac taagcagaaa accaagttat caggacagag     1860

atatttccca gttactccta atcaatgaag aaagtgagtt ggatattttt aaagcagtta     1920

actaattttt tcttacctaa tcttttggga gttttgcttg ttgatataac ctttttagtt     1980

aacctgaaag attccaaaaa ttgttcttaa gtgcttgaga ctggaaccaa aattaaattg     2040

tacttcataa aatcctctta tagagttact cttgccctag attgtaaatt aagtttggca     2100

ttattgtcag actggatgga gggtgaagta aaatagtatg aacaattaag aggctctccc     2160

cctcttgtct ttaagccata ttctcctaca tgtattttat aagaaaatgt taagtcaaat     2220

tttagtggct ctttaattcc tgacctcttc attctccttt tcagtataac ctcccctatg     2280

ctcatgccca cacagacaaa aaaacaaaac gaaatacaca cagaaaaaag tctttccaaa     2340

ctgtttaagt atttaaacat ctgagccaaa gcagatagaa gttattgtat aattgttaat     2400

cactttgcaa ataggggcta tcaaattacc tatattggca ttgctggatt ataaactcta     2460

tatctgtaat ataaagtgtt tgagttttta attgggctgt tatgatcagt agttgatttt     2520

gagaaagctc tatgagctct aagtaactgc atggtttttt gtttaatgta atataggaga     2580

cccttcacat tcccaaggaa tatattccaa aacatttttg tgaatatcta agtttgtgaa     2640

actactaggg catgatacag taaggtgtaa ttacagaatt tacgaaatgt aaatggcctc     2700

tacagagttt tatggaatac ctggtactaa cgtaggcagc tgcaaaacca cactgagtta     2760

cagctgtcag ccctcctcat tcctaaataa cttgccttac atatcagccc tcccacttct     2820

gaagttcaaa ttagtgcctc ggaaatgtag aatttattat ttgtcatttt ttttttttta     2880

gcatagattg agaacagttg aactcttaaa tcctcagatg ccaggggtct gctctagcat     2940

cagtaagtat ttagcagaaa ctaactccgt aatgaatgga attcaattcc acacatggtt     3000

tgttcaagca cacttaataa gtagcctatt ttttaaatgt ctttttaaaa tgtaaatatt     3060

tggatgaagt ttttctttgt tttgatatat tcatttgcta caccaactat gttttcagaa     3120

ttcatctttt gaacaacttg gtttcagaat atgtaaaatg actttaagga tcttgtgtat     3180

caaacctatc cccggatgtg tgagaataat gtgttcataa agcatggatc tcgctttggt     3240

tgtatagctt cctcatttac ttcatggtct tacatagctg gtgactttca gggctaatct     3300

gccctctaaa gcattgtccc aggagaggaa aaggaaatgg gacctcagaa gtagaagcct     3360

cagggaagga gtaaagtaga aatcagaaga aaagaagctt cacttgatag taataaggtt     3420

tttaacttca agtaccttca gaaaatgtga ttttgataag aggaaagggc aaatttagac     3480

cttaaaaaat atggaagaac tactgcctta aaagtgcatt tgtggcacat cagcctagaa     3540

ctgtatcatg gctgtgctgg ggagaagtaa atggtggtaa tgtaacattg ccacctttac     3600

ttaatgatgt gttattttcg aggtacagta gatcaatata gtaataggcg agcctcatat     3660

atagcattca tcttgtacaa tgatatccat acccttgata tgaaggaaaa ttgacttggt     3720

ttgtgcattt gaatactgaa ataatttttt aaaactcagt gacacatacc atctcttgcc     3780

aagactagac cctgtatttt agttcctaaa ttagatgttt aaatttaaaa acattttcag     3840

atgtacttaa gtacttccat agtacttttt tttttttttt tttttttgcc ccctgagacg     3900

gagtctctgt gtcacccagg ctggagtgca gtggtgcgat ctcggctcac tgcaacttct     3960

gcctcttggg ttcaagcagt tctccctgtc tcagcctcct gagtagcttg gattacaggc     4020

gcccgtcacc gcacctgcct aatttttgca tttttagtag agacggggtt tcgtcatttg     4080

gccaggctgg tcttgaactc ctgaccacag gtgatacgcc tgccttggcc tcccaaagtg     4140

tgctgggatt acaggcgtga gccactgtgc ccggcccact gttcactttt tgaatggcat     4200

cattttatag ctgtagaact aaaatcaatg tttgccccaa ttttcttaag taaaactcta     4260

ctttgagctc ttacctccaa cttagtaaaa agcagcttca cacacaaaca agattcttac     4320

tggtggaatg ttaggtttcg ttgttaagtt aatctgtcta taagctcatc cttagaggat     4380

atttgaggag gaagaacacc ttgcagctga cttgcaaaca tctaaataat ttatttcggg     4440

tgcttatgaa tgttactaat ggattttgta tgaattttta tcccttttca tttatacaaa     4500

aacctgggct tttatgttaa ttatatcatc tgaggttcta aggttttttt tttagatttt     4560

gaaatttagg gataatagct cttaggtttg ggtaccactt tgctgcagtt taagaaaggg     4620

ggaagggaac tcatttatta aacatcaatc acgtgctgtg ttctgtttgt tttctagtca     4680

tcatatcaca cacctttacg acagctcact gaaggaaggt gatactgttc ccattttgta     4740

gatggaatag acaaaacctg aatttaagta gcttgctcaa ggttccatat tgaatatgga     4800

aagttcaaat catctcagta atgaatatac catatatact tgctgtattg tatctatgat     4860

aattcagtta cccacaatac ccttttaaat ttctgttaat gacatacctt taaatgtctc     4920

cttgatgaac agaatcatgg tctttaaaaa cattttcatg ggttgattgc attttcaagc     4980

tctaaaggat tgaaagataa atcttcacgt taaaggtaag agtgaagtat ctgctcttgg     5040

gttacagaac cagatagtac tagaactaag attacagggt aaagctgctt ttatcttttt     5100

tctttttctt tttctttttt tttttgacat ggggtctcac tgtattgccc aggctggaat     5160

gcagtggcat gatctcagct cacggcagcc tctgcctctt gggctcaagc gattctcctg     5220

cttcagcttt ccaagtattt gggaccacag gcgcacacca caggcctggc taatgttttt     5280

gttttgtttt tggtagagac ggggtttcac catgttgcca ggctggtctc gaactcctga     5340

gctcaagtga ttcacccacc ttggcctcac aaagtgtcag gcttacaggc gtgagccact     5400

gcgcccggct cacagggtaa ggcttctgtc tggtgtgttg tattacggat tttgcttaat     5460

aggcacagtg aggcattaaa aagaaaattc agtatgcctg tagaaaggat aatccttgtt     5520

taaagtctcc aaattgcagt caaagatgtt ttgactgtgc ctttttttgt tcccctgctg     5580

tcccttatgt agacttctgt cagtacccat ggcagcctgt catcttgttg acatctcctt     5640

ctggactgtg agctctgtat ctggcttgtt tttcatcccc agcttctagt tcacaattag     5700

gtagaaccct attactcttt gaagaaggaa caagaaaatg tgggccagtt ttcatttgcc     5760

attcttccat gtgagttagt atggttcgta agtattcctg gtgatacgct agtattggca     5820

attctgtgag gttgaacaaa ggggtggtat ggtgtgctag cgtgggaatt aggagacctc     5880

tgggtcttga cagtgccctg gccactaagc aaaggcagtt catccttgga gtctcaatgt     5940

gcttttttgt taattgagat atgcttgaag tatcagccct aaatagtctg attctgtgac     6000

ctacaaaccc ttacttaatt cagtgttact ataaatgatt cttcccttaa acctactttt     6060

tacttagcaa aagagaaaaa aaaaaaaagg aaacgctcat gtcaggctgc ctgggtttga     6120

accccagatc ccctcttagt tggaggcaag ttgtatgatg cttcagcttt tggttcctgc     6180

ctcctaaggt tgttaggagt tactgtgtgt agctgcttag aacattgcct gggtctcagt     6240

aagccgctta agtgactgct ctcattttcg ctgtaaagca ccatactgta ataacatccc     6300

atgaagcatg gggcggggaa gagtatatgg taccttatgg actttgatgt ggtggggtag     6360

taggtaaatt ctgaatatgt aagctacata gtattctttt tgtaactaaa ggataaaagt     6420

tttaagatgg gcatgtaata tggctagcac tggattttaa tgatgagcca gagtaataag     6480

gctggcaagg ggagtttttg ttttgtaata aatctcttac acctgcacat ccagttcttt     6540

ttaaaaacac gtttgaagag gctccatatt tctcagtgaa gctgttgggg ttcatgttat     6600

ttttgaaaat catcttgcaa tttatttcag catcagactg aaccacccaa agaaaattag     6660

tctatttctg aacagttttt tcagaaacca tattggtctg atcacccaac atttatagaa     6720

ataggcgctt aaggcctaga ggcatttcag aaaggagaat gagaaatact gtggtcaaga     6780

gtagtgttca gatggagaac atcaagcatc tgctctgccc ttccacacac atcctcattt     6840

catcttcaca actgccctag gtaaccttgt tatctgtaat gaaacagcct caaggagcac     6900

agaggcactc actcctcacg tttggtctgt tgccatttcc ggcttggttg gaatagggta     6960

ggagcctttt ggcagggagc acattctcag taatgcagag tgcactcacc tgggttctag     7020

cttcaacact taggatttgc ttgatatttt gtattctctg aggcactgcc tgtatttgtt     7080

tctgctatca cagtccagag tcaagcttca tttataaaga ctgggcaggg catggtggct     7140

cactcctgta attccagcac tttgggaggc tgaggtgggt ggatcacttt aggtcaggag     7200

ttcaagacca gcctggccaa catggtgaaa ccccatctct actaaaaaat acaaaaaggc     7260

cgggcacggt ggctcacacc tgtaatccca acactttggg aggccaaggt gggcagaaca     7320

cctgaggtca ggagttcaag accatcctgg cgaacatagt gaaacctcgc ctctactaaa     7380

aatacaaaaa ttagccaggt gtggtggtgc atgcctgtaa tcccagctac ttgggaggct     7440

gaggcaggag aattgcttaa acctgggagg tggagattgt ggtgagctga gatcgtgcca     7500

ctgcactcca gcctgggaga tagaacgaga ctccatctca aaaaagaaca aaaacaatta     7560

gccgagcgag gtggtgcacg cctgtaatcc cagctactca tgaggctgag gcaggagaat     7620

cacttgaacc caggaggagg aggttgtagt gagtcaaggt tgcaccactg cactccagcc     7680

tgggtgacag agtgagactg tctcaaaaaa taagtacata aataataagt aaaagctact     7740

aacaattaaa aaataaataa ataaagacaa gactgtctgg aaaatggctc tcctaaaagg     7800

accagttgcc atcatccaca gtggaagatt caaagcagtt ggtccttggt acgtatgaga     7860

agcggatttc attcccttga attctacaga gcagtttatt agagtgaatg cattttaagg     7920

ccttgcattt gatatgtcat ccagttcata atcaagttgc ctttttctgg ctaaaacata     7980

atgattatgt atttttctca tttggtccta caagctgctg gccctttgtc cctccactgt     8040

gggaatcaga tctagaggag gctgagcctg cagacacagc agtggccaaa aggtcactct     8100

aagtgttttg tcttgactcc ttacttgaag tccacccagc tagcacacat ctggtttata     8160

ctgaagcccc ctgcctagaa atactcattt caggaaccac cagtaagcat ctgtgaccac     8220

acaggctttt tgactgatgg cttcccggat ctggtttcaa gggataaccc cgtctgtgtg     8280

catctatggt cttctctcta cagcgaggac tttgcagtgc tgcttgtggt ccacacaagg     8340

ggctcagagc tgagtctgaa ctgcttcatg gtcaccagct cctgtccctt ccagtcttga     8400

gaggcttttt tctccagatg gaacctttcc ttcccgccgt tttctcggtc tctggctgtt     8460

tttctcttgt gcccgtctaa ttggacacct cctggcttcc atctctgtgg ttctcctgcc     8520

tcacttcctg ttctgttgtt tttccgtttt gtcaaaatat ctcctatgtt cttggcttcc     8580

ttttcgtcgc caggttttca gctttccttt agctcttctt ctaatatggc ttctgcccac     8640

aaaagcctgc tctgtcagga tctcatggtt ctccacttgc cagaaccttc ttcagcctca     8700

gttcctcggc ctcaacttgt acgtttaacc cattgaccac caccccccaa attcaccttc     8760

atttctttga ccctgctcct cactcctttt ctgttgagga atctgttgac taactccagg     8820

ctcactcagg ctcaccgtcc tgctctctgc accagccttt ccagagcgtg ccagttctca     8880

tggcttcatc tgttaactgt tgatcacttc agtcctgatt tttagaccta aatggtttcc     8940

ttaacgccat tctaactgcc tgtgactcat tttcacttac agtgtttatt gtaacgccaa     9000

accaacaaat cacaggtgct tgcttctctc cataaatctc cccagtctaa ctttttgtca     9060

ttcaacatga ctcgtttatc caacctgaaa tcgcatatag ccccaagtat ggtgttttgt     9120

acacaggtat ttaataagtg acttccagtt ttggctctgc tatgaataaa aagagatttc     9180

agttctcttc actttgaaat ctaacaactc agagaacatt gaagaaattg gaatttagtt     9240

gggatgaaat acttgtggtt taaaatattt ctgttcatat tttctaattt gttgccggag     9300

gtcttgggtt ttctatttga gtgcttgcaa actcaatgtg atttctgtca gcatatctta     9360

ggtttgtttg ttatgaaact tatgcagtgt gaggttctat ctgaaaatgt tatttagcta     9420

tcttctggga ctatttaatg aaagtggggt catgaatcct taaaattctt gtgcagcttt     9480

gagaaacatt tctgttattt gggtatcagt ttgtaagtgt ggtaaagcca agatggaaac     9540

gagcactttg ctttcttggt tgttgttact ggtctaacct cctgcttgaa ctagtctgct     9600

gtcctgtcaa atgcatcttt ttatttacat gtcccttaaa ttaaagctga tcatgaaagt     9660

a                                                                     9661


<210>  12
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Leu Leu Pro Arg Leu Leu Leu Leu Leu Leu Leu Val Phe Pro 
1               5                   10                  15      


Ala Thr Val Leu Phe Arg Gly Gly Pro Arg Gly Leu Leu Ala Val Ala 
            20                  25                  30          


Gln Asp Leu Thr Glu Asp Glu Glu Thr Val Glu Asp Ser Ile Ile Glu 
        35                  40                  45              


Asp Glu Asp Asp Glu Ala Glu Val Glu Glu Asp Glu Pro Thr Asp Leu 
    50                  55                  60                  


Val Glu Asp Lys Glu Glu Glu Asp Val Ser Gly Glu Pro Glu Ala Ser 
65                  70                  75                  80  


Pro Ser Ala Asp Thr Thr Ile Leu Phe Val Lys Gly Glu Asp Phe Pro 
                85                  90                  95      


Ala Asn Asn Ile Val Lys Phe Leu Val Gly Phe Thr Asn Lys Gly Thr 
            100                 105                 110         


Glu Asp Phe Ile Val Glu Ser Leu Asp Ala Ser Phe Arg Tyr Pro Gln 
        115                 120                 125             


Asp Tyr Gln Phe Tyr Ile Gln Asn Phe Thr Ala Leu Pro Leu Asn Thr 
    130                 135                 140                 


Val Val Pro Pro Gln Arg Gln Ala Thr Phe Glu Tyr Ser Phe Ile Pro 
145                 150                 155                 160 


Ala Glu Pro Met Gly Gly Arg Pro Phe Gly Leu Val Ile Asn Leu Asn 
                165                 170                 175     


Tyr Lys Asp Leu Asn Gly Asn Val Phe Gln Asp Ala Val Phe Asn Gln 
            180                 185                 190         


Thr Val Thr Val Ile Glu Arg Glu Asp Gly Leu Asp Gly Glu Thr Ile 
        195                 200                 205             


Phe Met Tyr Met Phe Leu Ala Gly Leu Gly Leu Leu Val Ile Val Gly 
    210                 215                 220                 


Leu His Gln Leu Leu Glu Ser Arg Lys Arg Lys Arg Pro Ile Gln Lys 
225                 230                 235                 240 


Val Glu Met Gly Thr Ser Ser Gln Asn Asp Val Asp Met Ser Trp Ile 
                245                 250                 255     


Pro Gln Glu Thr Leu Asn Gln Ile Asn Lys Ala Ser Pro Arg Arg Leu 
            260                 265                 270         


Pro Arg Lys Arg Ala Gln Lys Arg Ser Val Gly Ser Asp Glu 
        275                 280                 285     


<210>  13
<211>  2140
<212>  DNA
<213>  Homo sapiens

<400>  13
gggaggaacg cgccgctagg cgggagagcg cggccatggc ggggccgggc gtccccggtg       60

cccccgcagc gcgctggaaa cgccacatcg tgcggcagct gcggcttcgg gaccgtacgc      120

aaaaggcgct tttcctggag ctggtgccgg cctataacca tctcttagag aaggctgagc      180

tgctggacaa gttctcaaag aagctgcagc cggagccaaa cagtgtcact cccaccaccc      240

accagggccc ctgggaggag tcagagcttg actcagacca agtcccatca ctggtcgcac      300

tgagggtgaa gtggcaggag gaggaggagg ggctccggct ggtctgtggt gagatggcct      360

accaggtggt ggagaagggc gcggccctgg gcacgctgga gtcggagctg cagcagaggc      420

aaagcaggct ggcagccctg gaggcccgcg tggcgcagct gcgagaggcg cgggcgcagc      480

aggcccagca ggtggaggag tggcgggcgc agaatgcggt gcagcgggca gcctacgagg      540

cgctgcgcgc gcacgtcggg ctccgggagg cggcactgcg caggctccag gaagaggcgc      600

gcgacctgct ggagaggctc gtgcagcgca aggcgcgcgc cgcggccgag cgcaacctgc      660

gcaacgagcg ccgggagcgg gccaagcagg cgcgggtgtc ccaggagctg aagaaggctg      720

ccaagcggac cgtgagcatc agcgagggcc cggacaccct aggcgatggg atgagggaga      780

gaagggagac tctggctctg gcccctgagc cagagcccct ggagaaggaa gcttgtgaga      840

agtggaagag gcccttcagg tctgcctcag ccacctccct gacgctgtcc cactgtgtgg      900

atgtggtgaa ggggcttctg gattttaaga agaggagagg tcactcaatt gggggagccc      960

ctgagcagcg ataccagatc atccctgtgt gtgtggctgc ccgacttcct acccgggctc     1020

aggatgtgct ggatgcccac ctctctgagg tcaatgctgt tcgttttggc cccaacagca     1080

gcctcctggc cactggaggg gctgaccgcc tgatccacct ctggaatgtt gtgggaagtc     1140

gcctggaggc caaccagacc ctggagggag ctggtggcag catcaccagt gtggactttg     1200

acccctcggg ctaccaggtt ttagcagcaa cttacaacca ggctgcccag ctctggaagg     1260

tgggggaggc acagtccaag gagacactgt ctggacacaa ggataaggtg acagctgcca     1320

aattcaagct aacgaggcac caggcagtga ctgggagccg cgaccggaca gtgaaggagt     1380

gggacctcgg ccgtgcctat tgctccagga ccatcaatgt cctttcctac tgtaatgacg     1440

tggtgtgtgg ggaccatatc atcattagtg gccacaatga ccagaagatc cggttctggg     1500

acagcagggg gccccactgc acccaggtca tccctgtgca gggccgggtc acctccctga     1560

gcctcagcca cgaccaactg cacctgctca gctgttcccg agacaacaca ctcaaggtca     1620

tcgacctgcg tgtcagcaac atccgccagg tgttcagggc cgatggcttc aagtgtggtt     1680

ctgactggac caaagctgtg ttcagcccgg acagaagcta tgcactggca ggctcctgtg     1740

atggggccct ttacatctgg gatgtggaca ccgggaaact ggagagcaga ctacagggac     1800

cccattgcgc tgccgtcaac gccgtggcct ggtgctactc cgggagccac atggtgagcg     1860

tggaccaggg caggaaggtt gtgctctggc agtagggcca cgacctgcct gcctgggctg     1920

gagctcttgc ccgaagcctg aagcttcctt cggcgccatg caggggttgg ggttgggact     1980

ggagctggcc ttgggattta atggggaaga aggcctggca ggacctggcc tgtttgttta     2040

aaaatgaagt atgggttggg ggattacgct agtttttctt tgtattttta tctctatctc     2100

ctcacttttt ctcccaaagt agaaaaaaat gatatctgaa                           2140


<210>  14
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Pro Gly Val Pro Gly Ala Pro Ala Ala Arg Trp Lys Arg 
1               5                   10                  15      


His Ile Val Arg Gln Leu Arg Leu Arg Asp Arg Thr Gln Lys Ala Leu 
            20                  25                  30          


Phe Leu Glu Leu Val Pro Ala Tyr Asn His Leu Leu Glu Lys Ala Glu 
        35                  40                  45              


Leu Leu Asp Lys Phe Ser Lys Lys Leu Gln Pro Glu Pro Asn Ser Val 
    50                  55                  60                  


Thr Pro Thr Thr His Gln Gly Pro Trp Glu Glu Ser Glu Leu Asp Ser 
65                  70                  75                  80  


Asp Gln Val Pro Ser Leu Val Ala Leu Arg Val Lys Trp Gln Glu Glu 
                85                  90                  95      


Glu Glu Gly Leu Arg Leu Val Cys Gly Glu Met Ala Tyr Gln Val Val 
            100                 105                 110         


Glu Lys Gly Ala Ala Leu Gly Thr Leu Glu Ser Glu Leu Gln Gln Arg 
        115                 120                 125             


Gln Ser Arg Leu Ala Ala Leu Glu Ala Arg Val Ala Gln Leu Arg Glu 
    130                 135                 140                 


Ala Arg Ala Gln Gln Ala Gln Gln Val Glu Glu Trp Arg Ala Gln Asn 
145                 150                 155                 160 


Ala Val Gln Arg Ala Ala Tyr Glu Ala Leu Arg Ala His Val Gly Leu 
                165                 170                 175     


Arg Glu Ala Ala Leu Arg Arg Leu Gln Glu Glu Ala Arg Asp Leu Leu 
            180                 185                 190         


Glu Arg Leu Val Gln Arg Lys Ala Arg Ala Ala Ala Glu Arg Asn Leu 
        195                 200                 205             


Arg Asn Glu Arg Arg Glu Arg Ala Lys Gln Ala Arg Val Ser Gln Glu 
    210                 215                 220                 


Leu Lys Lys Ala Ala Lys Arg Thr Val Ser Ile Ser Glu Gly Pro Asp 
225                 230                 235                 240 


Thr Leu Gly Asp Gly Met Arg Glu Arg Arg Glu Thr Leu Ala Leu Ala 
                245                 250                 255     


Pro Glu Pro Glu Pro Leu Glu Lys Glu Ala Cys Glu Lys Trp Lys Arg 
            260                 265                 270         


Pro Phe Arg Ser Ala Ser Ala Thr Ser Leu Thr Leu Ser His Cys Val 
        275                 280                 285             


Asp Val Val Lys Gly Leu Leu Asp Phe Lys Lys Arg Arg Gly His Ser 
    290                 295                 300                 


Ile Gly Gly Ala Pro Glu Gln Arg Tyr Gln Ile Ile Pro Val Cys Val 
305                 310                 315                 320 


Ala Ala Arg Leu Pro Thr Arg Ala Gln Asp Val Leu Asp Ala His Leu 
                325                 330                 335     


Ser Glu Val Asn Ala Val Arg Phe Gly Pro Asn Ser Ser Leu Leu Ala 
            340                 345                 350         


Thr Gly Gly Ala Asp Arg Leu Ile His Leu Trp Asn Val Val Gly Ser 
        355                 360                 365             


Arg Leu Glu Ala Asn Gln Thr Leu Glu Gly Ala Gly Gly Ser Ile Thr 
    370                 375                 380                 


Ser Val Asp Phe Asp Pro Ser Gly Tyr Gln Val Leu Ala Ala Thr Tyr 
385                 390                 395                 400 


Asn Gln Ala Ala Gln Leu Trp Lys Val Gly Glu Ala Gln Ser Lys Glu 
                405                 410                 415     


Thr Leu Ser Gly His Lys Asp Lys Val Thr Ala Ala Lys Phe Lys Leu 
            420                 425                 430         


Thr Arg His Gln Ala Val Thr Gly Ser Arg Asp Arg Thr Val Lys Glu 
        435                 440                 445             


Trp Asp Leu Gly Arg Ala Tyr Cys Ser Arg Thr Ile Asn Val Leu Ser 
    450                 455                 460                 


Tyr Cys Asn Asp Val Val Cys Gly Asp His Ile Ile Ile Ser Gly His 
465                 470                 475                 480 


Asn Asp Gln Lys Ile Arg Phe Trp Asp Ser Arg Gly Pro His Cys Thr 
                485                 490                 495     


Gln Val Ile Pro Val Gln Gly Arg Val Thr Ser Leu Ser Leu Ser His 
            500                 505                 510         


Asp Gln Leu His Leu Leu Ser Cys Ser Arg Asp Asn Thr Leu Lys Val 
        515                 520                 525             


Ile Asp Leu Arg Val Ser Asn Ile Arg Gln Val Phe Arg Ala Asp Gly 
    530                 535                 540                 


Phe Lys Cys Gly Ser Asp Trp Thr Lys Ala Val Phe Ser Pro Asp Arg 
545                 550                 555                 560 


Ser Tyr Ala Leu Ala Gly Ser Cys Asp Gly Ala Leu Tyr Ile Trp Asp 
                565                 570                 575     


Val Asp Thr Gly Lys Leu Glu Ser Arg Leu Gln Gly Pro His Cys Ala 
            580                 585                 590         


Ala Val Asn Ala Val Ala Trp Cys Tyr Ser Gly Ser His Met Val Ser 
        595                 600                 605             


Val Asp Gln Gly Arg Lys Val Val Leu Trp Gln 
    610                 615                 


<210>  15
<211>  1960
<212>  DNA
<213>  Homo sapiens

<400>  15
gagacgctaa gcggcgccgg gcgggagaag agcggagcag tggtcggaga tgtggcgacc       60

ggtgcagctc tgtcatttcc actctgctct gctgcacagc aggcagaagc cctggccgtc      120

ccctgctgtg ttcttcagga gaaacgtcag gggccttcct ccaaggttct ccagccccac      180

acccctgtgg aggaaggtgc tctccaccgc ggtagtgggg gcgcccctgc tcctcggagc      240

ccgctatgtc atggcagagg cacgggagaa gaggaggatg cggctcgtgg tggatggcat      300

ggggcgcttt ggcaggtctc tgaaggtcgg cctgcagatc tccctggact actggtggtg      360

caccaatgtt gtccttcgag gggtggaaga gaacagccca ggctacttgg aggtgatgtc      420

tgcgtgtcac cagcgggcgg ctgatgccct ggtggcaggg gccatcagca acgggggcct      480

ctacgtgaag ctgggccagg ggctgtgctc cttcaaccac ctgcttcccc ccgagtatac      540

ccggaccctg cgcgtgctag aggacagggc cctcaagcgg ggcttccagg aggtggatga      600

gttgttcctt gaggacttcc aggccctccc ccacgagctc ttccaggagt ttgactacca      660

gccaattgct gccgccagcc tggcacaggt gcacagagcc aagctgcacg atggcaccag      720

cgtggctgtg aaggtgcagt acatcgacct gcgggaccgc tttgatgggg acatccacac      780

cctggagctc ctgctgcggc tcgttgaggt catgcacccc agctttggct tcagctgggt      840

cctccaggac ctgaagggga ccctggccca ggagctggac ttcgagaatg agggccgcaa      900

cgcagagcgc tgtgcgcggg agctggcgca cttcccctac gtcgtggtgc cccgcgtgca      960

ctgggacaag tccagcaagc gcgtgctcac tgccgacttc tgcgccggct gcaaggtcaa     1020

cgatgtggag gccatcagga gccaggggct ggcagtgcat gacatagcag aaaagctcat     1080

caaggccttt gctgagcaga tattttacac cggcttcatc cactcggacc cacatcctgg     1140

caacgttctg gtgcggaaag gcccggacgg gaaagcggag ctggtgctgc tggaccacgg     1200

gctctaccag ttcctggagg agaaggaccg cgcagccctc tgccagctgt ggcgggccat     1260

catcctgcgg gacgacgccg ccatgagggc gcacgcagcc gcactggggg tgcaagacta     1320

cctcctgttc gccgagatgc tcatgcagcg ccccgtgcgc ctggggcagc tgtggggctc     1380

gcacctactg agccgcgaag aggcggccta catggtggac atggcccgcg agcgcttcga     1440

ggccgtcatg gcggtgctca gggagctgcc gcggcccatg ctgctggtgc tgcgcaacat     1500

caacaccgtg cgcgctatca acgtggccct cggcgccccc gtggaccgct acttccttat     1560

ggctaaaagg gctgtccggg gctggagccg cctggcgggc gccacgtatc ggggtgtcta     1620

cggcaccagc ctcctgcgcc acgccaaggt cgtctgggag atgctcaagt ttgaagtggc     1680

gctcaggctg gagaccttgg ccatgcggct gaccgccctc ctggctcgtg ctctggtcca     1740

cctgagcctc gtgcccccag cggaggagct ctaccagtac ctggagacct agggtgcagc     1800

cgcccagggc cggcggggcc cttttcacct tgggctgacg gaggtggcgg ggctagaggt     1860

gtagacaccc cgagccccgt gggcactcgc actggggggc tgtgacagca gctgggccag     1920

gaggccgtgt aatgaccaca cactcctctc aagcaaaaaa                           1960


<210>  16
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Trp Arg Pro Val Gln Leu Cys His Phe His Ser Ala Leu Leu His 
1               5                   10                  15      


Ser Arg Gln Lys Pro Trp Pro Ser Pro Ala Val Phe Phe Arg Arg Asn 
            20                  25                  30          


Val Arg Gly Leu Pro Pro Arg Phe Ser Ser Pro Thr Pro Leu Trp Arg 
        35                  40                  45              


Lys Val Leu Ser Thr Ala Val Val Gly Ala Pro Leu Leu Leu Gly Ala 
    50                  55                  60                  


Arg Tyr Val Met Ala Glu Ala Arg Glu Lys Arg Arg Met Arg Leu Val 
65                  70                  75                  80  


Val Asp Gly Met Gly Arg Phe Gly Arg Ser Leu Lys Val Gly Leu Gln 
                85                  90                  95      


Ile Ser Leu Asp Tyr Trp Trp Cys Thr Asn Val Val Leu Arg Gly Val 
            100                 105                 110         


Glu Glu Asn Ser Pro Gly Tyr Leu Glu Val Met Ser Ala Cys His Gln 
        115                 120                 125             


Arg Ala Ala Asp Ala Leu Val Ala Gly Ala Ile Ser Asn Gly Gly Leu 
    130                 135                 140                 


Tyr Val Lys Leu Gly Gln Gly Leu Cys Ser Phe Asn His Leu Leu Pro 
145                 150                 155                 160 


Pro Glu Tyr Thr Arg Thr Leu Arg Val Leu Glu Asp Arg Ala Leu Lys 
                165                 170                 175     


Arg Gly Phe Gln Glu Val Asp Glu Leu Phe Leu Glu Asp Phe Gln Ala 
            180                 185                 190         


Leu Pro His Glu Leu Phe Gln Glu Phe Asp Tyr Gln Pro Ile Ala Ala 
        195                 200                 205             


Ala Ser Leu Ala Gln Val His Arg Ala Lys Leu His Asp Gly Thr Ser 
    210                 215                 220                 


Val Ala Val Lys Val Gln Tyr Ile Asp Leu Arg Asp Arg Phe Asp Gly 
225                 230                 235                 240 


Asp Ile His Thr Leu Glu Leu Leu Leu Arg Leu Val Glu Val Met His 
                245                 250                 255     


Pro Ser Phe Gly Phe Ser Trp Val Leu Gln Asp Leu Lys Gly Thr Leu 
            260                 265                 270         


Ala Gln Glu Leu Asp Phe Glu Asn Glu Gly Arg Asn Ala Glu Arg Cys 
        275                 280                 285             


Ala Arg Glu Leu Ala His Phe Pro Tyr Val Val Val Pro Arg Val His 
    290                 295                 300                 


Trp Asp Lys Ser Ser Lys Arg Val Leu Thr Ala Asp Phe Cys Ala Gly 
305                 310                 315                 320 


Cys Lys Val Asn Asp Val Glu Ala Ile Arg Ser Gln Gly Leu Ala Val 
                325                 330                 335     


His Asp Ile Ala Glu Lys Leu Ile Lys Ala Phe Ala Glu Gln Ile Phe 
            340                 345                 350         


Tyr Thr Gly Phe Ile His Ser Asp Pro His Pro Gly Asn Val Leu Val 
        355                 360                 365             


Arg Lys Gly Pro Asp Gly Lys Ala Glu Leu Val Leu Leu Asp His Gly 
    370                 375                 380                 


Leu Tyr Gln Phe Leu Glu Glu Lys Asp Arg Ala Ala Leu Cys Gln Leu 
385                 390                 395                 400 


Trp Arg Ala Ile Ile Leu Arg Asp Asp Ala Ala Met Arg Ala His Ala 
                405                 410                 415     


Ala Ala Leu Gly Val Gln Asp Tyr Leu Leu Phe Ala Glu Met Leu Met 
            420                 425                 430         


Gln Arg Pro Val Arg Leu Gly Gln Leu Trp Gly Ser His Leu Leu Ser 
        435                 440                 445             


Arg Glu Glu Ala Ala Tyr Met Val Asp Met Ala Arg Glu Arg Phe Glu 
    450                 455                 460                 


Ala Val Met Ala Val Leu Arg Glu Leu Pro Arg Pro Met Leu Leu Val 
465                 470                 475                 480 


Leu Arg Asn Ile Asn Thr Val Arg Ala Ile Asn Val Ala Leu Gly Ala 
                485                 490                 495     


Pro Val Asp Arg Tyr Phe Leu Met Ala Lys Arg Ala Val Arg Gly Trp 
            500                 505                 510         


Ser Arg Leu Ala Gly Ala Thr Tyr Arg Gly Val Tyr Gly Thr Ser Leu 
        515                 520                 525             


Leu Arg His Ala Lys Val Val Trp Glu Met Leu Lys Phe Glu Val Ala 
    530                 535                 540                 


Leu Arg Leu Glu Thr Leu Ala Met Arg Leu Thr Ala Leu Leu Ala Arg 
545                 550                 555                 560 


Ala Leu Val His Leu Ser Leu Val Pro Pro Ala Glu Glu Leu Tyr Gln 
                565                 570                 575     


Tyr Leu Glu Thr 
            580 


<210>  17
<211>  6098
<212>  DNA
<213>  Homo sapiens

<400>  17
atgtccggct ccaaaagcgt gagccccccg ggctacgcgg cgcagaagac tgcggcgccg       60

gcgccccggg gaggccccga acaccgctct gcgtggggcg aggccgattc ccgcgcgaat      120

ggctaccccc atgcccccgg gggctctgcc cgcggctcca ccaagaaacc cgggggggcg      180

gtgaccccgc agcagcagca gcgcctggcc agccgctggc gcagcgacga cgacgacgat      240

cctccgctga gcggtgacga ccccctggcc gggggcttcg gcttcagctt ccgctccaag      300

tccgcctggc aggagcgcgg cggcgacgac tgcggtcgcg gcagccgccg gcagcggcgg      360

ggcgcggcca gcgggggcag cacccgggcg ccccctgcgg gcggcggcgg cggctcggcg      420

gcggcggctg cctcggcggg cgggacggag gtgcgccctc gctcggtgga ggtgggtctg      480

gaggagcggc ggggcaaggg gcgcgcggcc gacgagctgg aggccggcgc cgtcgagggc      540

ggcgaggggt ccggggatgg cggcagctcg gcggactcgg gctcgggcgc ggggcccggc      600

gcggtgctgt ccctgggcgc ctgctgcctg gcgttgctgc agatattccg ctccaagaag      660

ttcccgtcgg acaaactgga gcggctgtac cagcgctact tcttccgcct gaaccagagc      720

agcctcacca tgctcatggc cgtgctggtg ctcgtgtgcc tggtcatgtt ggccttccac      780

gcggcgcggc ccccgctcca gctgccctac ctggccgtgc tggcggccgc cgtcggcgtg      840

atcctcatca tggctgtgct ttgcaaccgc gccgccttcc accaggacca catgggcctg      900

gcctgctatg cgctcatcgc cgtggtgctg gccgtccagg tggtgggcct gctgctgccg      960

cagccacgca gcgcctctga gggcatctgg tggaccgtgt tcttcatcta caccatctac     1020

acgctgctgc ccgtgcgcat gcgggccgca gtgctcagcg gggtgctcct gtccgccctc     1080

cacctggcca tcgccctgcg caccaacgcc caggaccagt tcctgctgaa gcagcttgtc     1140

tccaatgttc tcattttctc ctgcaccaac atcgtgggtg tctgcaccca ctatccggct     1200

gaggtctccc agagacaggc tttccaggag acccgagagt gcatccaggc gcggctccac     1260

tcgcagcggg agaaccagca gcaggaacgg ctcctgctgt ctgtccttcc ccgtcatgtt     1320

gccatggaga tgaaagcaga catcaacgcc aagcaggagg atatgatgtt ccataagatt     1380

tacatccaga aacatgacaa cgtgagcatc ctgtttgctg acatcgaggg cttcaccagc     1440

ctggcgtccc agtgcactgc acaggaactg gtcatgaccc tcaacgagct cttcgcccgc     1500

tttgacaagc tggccgcaga gaatcactgt ttacgtatta agatccttgg ggattgttat     1560

tactgcgtct cggggctgcc tgaagcaagg gctgaccacg cccactgctg tgtggagatg     1620

ggcatggaca tgatcgaggc catctcgttg gtccgggagg tgacaggggt gaacgtgaac     1680

atgcgtgtgg gaattcacag cgggcgagta cactgcggtg tccttggtct caggaagtgg     1740

cagttcgacg tctggtctaa cgatgtcacg ctagccaacc acatggaggc tggcggcaag     1800

gcaggacgca tccacatcac caaggctaca ctcaactacc tgaatgggga ctacgaggtg     1860

gagccaggct gtgggggcga gcgcaacgcc tacctcaagg agcacagtat cgagaccttc     1920

ctcatcctgc gctgcaccca gaagcggaaa gaagagaagg ccatgatcgc caagatgaac     1980

cgccagagaa ccaactccat cgggcacaac ccaccacact ggggggctga gcgccccttc     2040

tacaaccacc tgggtggcaa ccaggtgtcc aaggagatga agcggatggg ctttgaagac     2100

cccaaggaca agaacgccca ggagagtgcg aaccctgagg atgaagtgga tgagtttctg     2160

ggccgtgcca ttgacgccag gagcattgat aggcttcggt ctgagcacgt ccgcaagttc     2220

ctcctgacct tcagggagcc tgacttagag aagaagtact ccaagcaggt agacgaccga     2280

tttggtgcct atgtggcgtg tgcctcgctc gtcttcctct tcatctgctt tgtccagatc     2340

accatcgtgc cccactccat attcatgctc agcttctacc tgacctgttc cctgctgctg     2400

accttggtgg tgtttgtgtc tgtgatctac tcctgcgtaa agctcttccc ctccccactg     2460

cagaccctct ccaggaagat cgtgcggtcc aagatgaaca gcaccctggt tggggtgttc     2520

accatcaccc tggtgttcct ggcggctttt gtcaacatgt tcacgtgcaa ctccagggac     2580

ctgctgggct gcttggcaca ggagcacaac atcagcgcga gccaggtcaa cgcgtgtcac     2640

gtggcggagt cggccgtcaa ctacagcctg ggcgatgagc agggcttctg tggcagcccc     2700

tggcccaact gcaacttccc cgagtacttc acctacagcg tgctgctcag cctgctggcc     2760

tgctccgtgt tcctgcagat cagctgcatc gggaagctgg tgctcatgct ggccatcgag     2820

ctcatctacg tgctcatcgt ggaggtgcca ggtgtcacgc tcttcgacaa cgccgacctg     2880

ctggtcaccg ccaacgccat agacttcttc aacaacggga cctcccagtg ccctgagcat     2940

gcaaccaagg tggcattgaa ggtggtgacg cccatcatca tctcagtctt tgtgctggcc     3000

ctgtacctgc acgcccagca ggtggagtcc actgcccgcc tcgacttcct ctggaaactg     3060

caggccacag aggagaaaga ggagatggag gagctgcagg cctacaaccg gcggctgctg     3120

cacaacatcc tgcccaagga cgtggccgct cacttcctgg cccgcgagcg gcgcaatgat     3180

gagctctact atcagtcctg tgagtgtgtg gcggtcatgt tcgcctccat cgccaacttc     3240

tccgagttct acgttgagct ggaggccaac aacgagggtg tcgagtgcct gcggctactc     3300

aatgagatca tcgctgactt tgatgagatc atcagcgagg atcggttccg gcagctggag     3360

aagatcaaga ccatcggcag cacctacatg gctgcctccg gcctcaacga ctctacctac     3420

gacaaggtgg gcaagaccca catcaaggca ctggccgact ttgccatgaa gctgatggac     3480

cagatgaagt acatcaatga gcactccttc aacaacttcc agatgaagat cgggctcaac     3540

atcggccccg tggtggccgg ggtgataggg gcacgaaagc ctcagtacga catctggggc     3600

aataccgtga acgtggccag ccgcatggac agcaccggtg tacccgaccg catccaggtc     3660

accacagaca tgtaccaggt gctggctgcc aacacgtacc agctggagtg ccggggcgtg     3720

gtcaaggtca agggcaaagg cgagatgatg acctacttcc tcaatggagg gcccccgctc     3780

agttagcagc tgttggccaa tggtgccagg cagcctggcc tccagaggca tggaagcagc     3840

ttctctgtgt gccgggggtg gcggggaagc catgctccag cccgcagggc tgcgctgctg     3900

agattttcca cttggactcc agagcagctt ctgcctttgc tggtgggcag cggcctctgt     3960

cccaggcccc ggggtgccag cgtcctgcga gcacccagct gaccaaagat gtttccctct     4020

gtagaagact ctgctagact gggtctgaag cttgagtttt ctaacaggtg ctgctgcaca     4080

ggtggaaagg agccgtggga atgtgtgtgt ggcacggccc agacaagggc agggctgagg     4140

ggcctccgac tcagctgggg gtagacgggc tcgaatgtgg cctgggagag cctagggggc     4200

cccaggggtc tgcttttcta tgtgagcctt taaacttcag acaggccacc accctgcacc     4260

tgcaggggct ttggcacagg agtgctggct ttggagggac tgtggccttc atcgtggtcc     4320

tctgcccaca cctccacgca cacagacagt gccctaggag ggaaacagaa ctaattacga     4380

gggggaggca agaggacgcc aagcaaggag tggtgattct gagaaaaata tttattaaat     4440

aaaacaaaac aagttctccg tgcccttctt tagactatgc tagttgtatg cgtgtaagag     4500

acacacaagc aaacgaggac gccactcggg gggagggcgg ggatccccac ttgtcttttt     4560

tgtatttttt attttgtatt attgaaagcc ttggagatct cacagataga tatgccaaat     4620

tctatatttt gtaaattctc tatattagaa aacagctgtg cacagcaggg cgggtgtgct     4680

catttgtact gtgtgtatgt cggtgtatgt actggtgtat atgtgtgtgt gttcatgctg     4740

tggaactggt ctcacacagg atgtgtttcc ctcatttcag atttggcagt tttgggtttt     4800

ccaaggtacc accagagcag tgggtgtgtg cttttggggt accatatgct cagattaagt     4860

aggaggatgc atggacacac tgccccatct tttctgacac acgcacacgt atgtacacac     4920

atgcacacac cctccttccc ctaagcaaaa cgcagatgga ataagaaaac aaaaagctgc     4980

tttcccatcc caggccgagc tggaaccaag ggaagcaatc tcatcctgcg acaggcagtg     5040

tggtgccctc cacaccctga gatttcagac gtttgcggct tacagaggca gcgcccacag     5100

attccagagt gcttacagaa ggccaggtgc tttgcaggct gggacgagga agccaagcct     5160

ccctggccta ctcagttggc caaggtgcag gtggctcttc ctggagatgt tcactcagac     5220

tgggggatgc aatgtgcagc cttcaggttt gcggaaaggg agtggccttg acctccaccg     5280

gcaaaccagg cagaggaatg ggtagagccc agctttagag tccacaggga aagctagcag     5340

gaattttgtt ttagtgggag ggggcagtta aacataccaa gaaaaaaata ctatttttat     5400

aacctatgag gaagacattt ggaaaatgat actctagcac agaattcagt ggaatcctta     5460

gggcccatgc ccaaatcttt ccattgcttc tcaggttaga atgatcttca cctccaacat     5520

gagcttggag gtgatgaggc agtggctctg tgccagctgc cacaatgtga ctttgatgtc     5580

cacctgtacc acctctcact gggctctagc accaccctcc cctccccgca caccaactga     5640

acacagctct gagaagcaaa gtgtgtggac ccaaaactgc caagcctgag tctgtcccgt     5700

gcttctgctg ctccatcctt tgagttctgc attgccatcc tgacgtcggc cacaggaggc     5760

ctgctttctt ccagctgttg ttctcaagtt ccctgcccct ccacatcgcc cgccagtggt     5820

gttgggtttt cgttctgctt ccaacctgag taaagtgtgt gtgctgagtt catcccatgt     5880

tctcccatgg tcatggcttc ccggccccat ggggacccct ctcccatccc agcagtgact     5940

ggtgacagtg tgcaggtgca gtgctagctc ttcgttccct ctaaagggtg tgcactcttt     6000

ttattcctac tcttgcaaaa acagatacga ttatgatttc ccatggaaat tgaaaagtct     6060

atttaaataa tttaactatt aaacactttc actggtaa                             6098


<210>  18
<211>  1261
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Gly Ser Lys Ser Val Ser Pro Pro Gly Tyr Ala Ala Gln Lys 
1               5                   10                  15      


Thr Ala Ala Pro Ala Pro Arg Gly Gly Pro Glu His Arg Ser Ala Trp 
            20                  25                  30          


Gly Glu Ala Asp Ser Arg Ala Asn Gly Tyr Pro His Ala Pro Gly Gly 
        35                  40                  45              


Ser Ala Arg Gly Ser Thr Lys Lys Pro Gly Gly Ala Val Thr Pro Gln 
    50                  55                  60                  


Gln Gln Gln Arg Leu Ala Ser Arg Trp Arg Ser Asp Asp Asp Asp Asp 
65                  70                  75                  80  


Pro Pro Leu Ser Gly Asp Asp Pro Leu Ala Gly Gly Phe Gly Phe Ser 
                85                  90                  95      


Phe Arg Ser Lys Ser Ala Trp Gln Glu Arg Gly Gly Asp Asp Cys Gly 
            100                 105                 110         


Arg Gly Ser Arg Arg Gln Arg Arg Gly Ala Ala Ser Gly Gly Ser Thr 
        115                 120                 125             


Arg Ala Pro Pro Ala Gly Gly Gly Gly Gly Ser Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ser Ala Gly Gly Thr Glu Val Arg Pro Arg Ser Val Glu Val Gly Leu 
145                 150                 155                 160 


Glu Glu Arg Arg Gly Lys Gly Arg Ala Ala Asp Glu Leu Glu Ala Gly 
                165                 170                 175     


Ala Val Glu Gly Gly Glu Gly Ser Gly Asp Gly Gly Ser Ser Ala Asp 
            180                 185                 190         


Ser Gly Ser Gly Ala Gly Pro Gly Ala Val Leu Ser Leu Gly Ala Cys 
        195                 200                 205             


Cys Leu Ala Leu Leu Gln Ile Phe Arg Ser Lys Lys Phe Pro Ser Asp 
    210                 215                 220                 


Lys Leu Glu Arg Leu Tyr Gln Arg Tyr Phe Phe Arg Leu Asn Gln Ser 
225                 230                 235                 240 


Ser Leu Thr Met Leu Met Ala Val Leu Val Leu Val Cys Leu Val Met 
                245                 250                 255     


Leu Ala Phe His Ala Ala Arg Pro Pro Leu Gln Leu Pro Tyr Leu Ala 
            260                 265                 270         


Val Leu Ala Ala Ala Val Gly Val Ile Leu Ile Met Ala Val Leu Cys 
        275                 280                 285             


Asn Arg Ala Ala Phe His Gln Asp His Met Gly Leu Ala Cys Tyr Ala 
    290                 295                 300                 


Leu Ile Ala Val Val Leu Ala Val Gln Val Val Gly Leu Leu Leu Pro 
305                 310                 315                 320 


Gln Pro Arg Ser Ala Ser Glu Gly Ile Trp Trp Thr Val Phe Phe Ile 
                325                 330                 335     


Tyr Thr Ile Tyr Thr Leu Leu Pro Val Arg Met Arg Ala Ala Val Leu 
            340                 345                 350         


Ser Gly Val Leu Leu Ser Ala Leu His Leu Ala Ile Ala Leu Arg Thr 
        355                 360                 365             


Asn Ala Gln Asp Gln Phe Leu Leu Lys Gln Leu Val Ser Asn Val Leu 
    370                 375                 380                 


Ile Phe Ser Cys Thr Asn Ile Val Gly Val Cys Thr His Tyr Pro Ala 
385                 390                 395                 400 


Glu Val Ser Gln Arg Gln Ala Phe Gln Glu Thr Arg Glu Cys Ile Gln 
                405                 410                 415     


Ala Arg Leu His Ser Gln Arg Glu Asn Gln Gln Gln Glu Arg Leu Leu 
            420                 425                 430         


Leu Ser Val Leu Pro Arg His Val Ala Met Glu Met Lys Ala Asp Ile 
        435                 440                 445             


Asn Ala Lys Gln Glu Asp Met Met Phe His Lys Ile Tyr Ile Gln Lys 
    450                 455                 460                 


His Asp Asn Val Ser Ile Leu Phe Ala Asp Ile Glu Gly Phe Thr Ser 
465                 470                 475                 480 


Leu Ala Ser Gln Cys Thr Ala Gln Glu Leu Val Met Thr Leu Asn Glu 
                485                 490                 495     


Leu Phe Ala Arg Phe Asp Lys Leu Ala Ala Glu Asn His Cys Leu Arg 
            500                 505                 510         


Ile Lys Ile Leu Gly Asp Cys Tyr Tyr Cys Val Ser Gly Leu Pro Glu 
        515                 520                 525             


Ala Arg Ala Asp His Ala His Cys Cys Val Glu Met Gly Met Asp Met 
    530                 535                 540                 


Ile Glu Ala Ile Ser Leu Val Arg Glu Val Thr Gly Val Asn Val Asn 
545                 550                 555                 560 


Met Arg Val Gly Ile His Ser Gly Arg Val His Cys Gly Val Leu Gly 
                565                 570                 575     


Leu Arg Lys Trp Gln Phe Asp Val Trp Ser Asn Asp Val Thr Leu Ala 
            580                 585                 590         


Asn His Met Glu Ala Gly Gly Lys Ala Gly Arg Ile His Ile Thr Lys 
        595                 600                 605             


Ala Thr Leu Asn Tyr Leu Asn Gly Asp Tyr Glu Val Glu Pro Gly Cys 
    610                 615                 620                 


Gly Gly Glu Arg Asn Ala Tyr Leu Lys Glu His Ser Ile Glu Thr Phe 
625                 630                 635                 640 


Leu Ile Leu Arg Cys Thr Gln Lys Arg Lys Glu Glu Lys Ala Met Ile 
                645                 650                 655     


Ala Lys Met Asn Arg Gln Arg Thr Asn Ser Ile Gly His Asn Pro Pro 
            660                 665                 670         


His Trp Gly Ala Glu Arg Pro Phe Tyr Asn His Leu Gly Gly Asn Gln 
        675                 680                 685             


Val Ser Lys Glu Met Lys Arg Met Gly Phe Glu Asp Pro Lys Asp Lys 
    690                 695                 700                 


Asn Ala Gln Glu Ser Ala Asn Pro Glu Asp Glu Val Asp Glu Phe Leu 
705                 710                 715                 720 


Gly Arg Ala Ile Asp Ala Arg Ser Ile Asp Arg Leu Arg Ser Glu His 
                725                 730                 735     


Val Arg Lys Phe Leu Leu Thr Phe Arg Glu Pro Asp Leu Glu Lys Lys 
            740                 745                 750         


Tyr Ser Lys Gln Val Asp Asp Arg Phe Gly Ala Tyr Val Ala Cys Ala 
        755                 760                 765             


Ser Leu Val Phe Leu Phe Ile Cys Phe Val Gln Ile Thr Ile Val Pro 
    770                 775                 780                 


His Ser Ile Phe Met Leu Ser Phe Tyr Leu Thr Cys Ser Leu Leu Leu 
785                 790                 795                 800 


Thr Leu Val Val Phe Val Ser Val Ile Tyr Ser Cys Val Lys Leu Phe 
                805                 810                 815     


Pro Ser Pro Leu Gln Thr Leu Ser Arg Lys Ile Val Arg Ser Lys Met 
            820                 825                 830         


Asn Ser Thr Leu Val Gly Val Phe Thr Ile Thr Leu Val Phe Leu Ala 
        835                 840                 845             


Ala Phe Val Asn Met Phe Thr Cys Asn Ser Arg Asp Leu Leu Gly Cys 
    850                 855                 860                 


Leu Ala Gln Glu His Asn Ile Ser Ala Ser Gln Val Asn Ala Cys His 
865                 870                 875                 880 


Val Ala Glu Ser Ala Val Asn Tyr Ser Leu Gly Asp Glu Gln Gly Phe 
                885                 890                 895     


Cys Gly Ser Pro Trp Pro Asn Cys Asn Phe Pro Glu Tyr Phe Thr Tyr 
            900                 905                 910         


Ser Val Leu Leu Ser Leu Leu Ala Cys Ser Val Phe Leu Gln Ile Ser 
        915                 920                 925             


Cys Ile Gly Lys Leu Val Leu Met Leu Ala Ile Glu Leu Ile Tyr Val 
    930                 935                 940                 


Leu Ile Val Glu Val Pro Gly Val Thr Leu Phe Asp Asn Ala Asp Leu 
945                 950                 955                 960 


Leu Val Thr Ala Asn Ala Ile Asp Phe Phe Asn Asn Gly Thr Ser Gln 
                965                 970                 975     


Cys Pro Glu His Ala Thr Lys Val Ala Leu Lys Val Val Thr Pro Ile 
            980                 985                 990         


Ile Ile Ser Val Phe Val Leu Ala  Leu Tyr Leu His Ala  Gln Gln Val 
        995                 1000                 1005             


Glu Ser  Thr Ala Arg Leu Asp  Phe Leu Trp Lys Leu  Gln Ala Thr 
    1010                 1015                 1020             


Glu Glu  Lys Glu Glu Met Glu  Glu Leu Gln Ala Tyr  Asn Arg Arg 
    1025                 1030                 1035             


Leu Leu  His Asn Ile Leu Pro  Lys Asp Val Ala Ala  His Phe Leu 
    1040                 1045                 1050             


Ala Arg  Glu Arg Arg Asn Asp  Glu Leu Tyr Tyr Gln  Ser Cys Glu 
    1055                 1060                 1065             


Cys Val  Ala Val Met Phe Ala  Ser Ile Ala Asn Phe  Ser Glu Phe 
    1070                 1075                 1080             


Tyr Val  Glu Leu Glu Ala Asn  Asn Glu Gly Val Glu  Cys Leu Arg 
    1085                 1090                 1095             


Leu Leu  Asn Glu Ile Ile Ala  Asp Phe Asp Glu Ile  Ile Ser Glu 
    1100                 1105                 1110             


Asp Arg  Phe Arg Gln Leu Glu  Lys Ile Lys Thr Ile  Gly Ser Thr 
    1115                 1120                 1125             


Tyr Met  Ala Ala Ser Gly Leu  Asn Asp Ser Thr Tyr  Asp Lys Val 
    1130                 1135                 1140             


Gly Lys  Thr His Ile Lys Ala  Leu Ala Asp Phe Ala  Met Lys Leu 
    1145                 1150                 1155             


Met Asp  Gln Met Lys Tyr Ile  Asn Glu His Ser Phe  Asn Asn Phe 
    1160                 1165                 1170             


Gln Met  Lys Ile Gly Leu Asn  Ile Gly Pro Val Val  Ala Gly Val 
    1175                 1180                 1185             


Ile Gly  Ala Arg Lys Pro Gln  Tyr Asp Ile Trp Gly  Asn Thr Val 
    1190                 1195                 1200             


Asn Val  Ala Ser Arg Met Asp  Ser Thr Gly Val Pro  Asp Arg Ile 
    1205                 1210                 1215             


Gln Val  Thr Thr Asp Met Tyr  Gln Val Leu Ala Ala  Asn Thr Tyr 
    1220                 1225                 1230             


Gln Leu  Glu Cys Arg Gly Val  Val Lys Val Lys Gly  Lys Gly Glu 
    1235                 1240                 1245             


Met Met  Thr Tyr Phe Leu Asn  Gly Gly Pro Pro Leu  Ser 
    1250                 1255                 1260     


<210>  19
<211>  4480
<212>  DNA
<213>  Homo sapiens

<400>  19
gagttcgctg ctgtcccggt tcctctcgag tcggctccaa ctgccagccc gggttggcgc       60

catgtacgcc gtgtacaaac aggcgcatcc gcccaccggt ctggagttct ccatgtactg      120

caacttcttc aacaacagcg agcgcaacct ggtagtggcc gggacctcgc agctctacgt      180

gtaccgcctc aaccgcgacg ccgaggctct gaccaagaat gacaggagca cagaggggaa      240

ggcccaccgg gagaagctcg agcttgctgc ctccttctcc ttctttggca acgtcatgtc      300

catggccagc gtgcagctgg caggagccaa gcgggatgcc ctgctcctaa gcttcaagga      360

tgccaagctg tctgtggtgg agtacgaccc gggcacccat gacctgaaga ccctgtcact      420

gcactacttt gaggagcctg agcttcggga cgggtttgtg cagaatgtac acacgccgcg      480

agtgcgggtg gaccccgacg ggcgctgtgc agccatgctt gtctacggca cgcggctggt      540

ggtcctgccc ttccgcaggg agagcctggc tgaggagcac gaggggctcg tgggtgaggg      600

gcagaggtcc agcttcctgc ccagctacat catcgacgtg cgggccctag acgagaagct      660

gctcaacatc atcgacctgc agttcctgca tggctactac gagcctaccc tcctcatcct      720

gtttgagccc aaccagacct ggcctgggcg cgtggccgtg cggcaggaca cgtgctccat      780

tgtggccatc tcactgaaca tcacgcagaa ggtgcacccc gtcatctggt ccctcaccag      840

cctgcccttt gactgcaccc aggctctggc tgtgcccaag cccataggtg gggtggtggt      900

gtttgccgtc aactcgctgt tgtacctgaa ccagagcgtc cccccgtatg gcgtggctct      960

caacagcctc accacaggaa ccacggcttt cccgcttcgc acccaggagg gtgtgcggat     1020

caccctggac tgcgcccagg ccaccttcat ctcctacgac aagatggtca tctccctcaa     1080

gggcggcgag atctacgtgc tgaccctcat caccgacggc atgcgcagtg tccgagcgtt     1140

ccactttgac aaggcggccg ccagcgtcct caccaccagc atggtcacca tggagcccgg     1200

gtacctgttc ctgggttctc gcctgggcaa ttccctcctc ctcaagtaca cggagaagct     1260

gcaggagccc ccggccagtg ctgtccgtga ggctgccgac aaggaagagc ctccctcaaa     1320

gaagaagcga gtggatgcga cggccggctg gtcagctgcg ggtaagtcgg tgccgcagga     1380

tgaggtggac gagattgaag tgtacggcag cgaggcccag tcgggaacac agctggccac     1440

ctactccttt gaggtgtgtg acagcatcct gaacattgga ccctgtgcca atgccgccgt     1500

gggcgagcct gccttcctct ctgaagagtt tcagaacagc cccgagccgg acctggagat     1560

tgtggtttgc tccggccacg ggaagaacgg ggctttgtcg gtgctgcaga agagcatccg     1620

gccccaggtg gtgacaacct ttgagcttcc cggctgctat gacatgtgga cagtcatcgc     1680

cccggtgcgt aaggaggagg aggacaatcc caagggggag ggcacagagc aggaacccag     1740

caccacccct gaagcagacg acgacggccg cagacacgga ttcctgattc tgagccggga     1800

agactccacc atgatcctgc agacggggca ggagatcatg gagctggaca ccagtggctt     1860

cgccactcag ggccccacgg tctttgctgg gaacatcggg gacaaccgct acattgtcca     1920

agtgtcacca ctgggcatcc gcctgctgga aggagtgaat cagctgcact tcatccccgt     1980

ggacctgggc gcccccatcg tgcagtgcgc cgtggccgac ccctatgtgg tcatcatgag     2040

tgccgagggc cacgtcacca tgttcctgct gaagagtgac tcctacggtg gccgccacca     2100

ccgcctggcg ctgcacaagc ccccgctgca ccatcagtcc aaggtgatta cgctgtgcct     2160

gtaccgagac ctcagcggca tgttcaccac tgagagccgc ctgggtgggg cccgtgacga     2220

gctcgggggc cgcagtggcc cggaggccga gggcctgggc tcagagacta gccccacagt     2280

ggatgacgag gaggagatgc tgtatgggga ttcgggctcc ctcttcagcc ccagcaagga     2340

ggaggcccga agaagcagcc agccccctgc tgaccgggac cctgcaccct tccgggcaga     2400

gcctacccac tggtgcctgc tggtgcggga gaatggcacc atggagatct accagcttcc     2460

cgactggcgg ctggtgttcc tggtgaagaa cttccctgtg gggcagcggg tccttgtgga     2520

cagctccttt ggacagccca ctacacaggg cgaggcccgc agggaggagg ccacgcgcca     2580

gggggagctg cccctcgtca aggaggtgct gctggtggcg ctgggcagcc gccagagcag     2640

gccctacctg ctggtgcatg tggaccaaga gctgcttatc tacgaggcct tcccccacga     2700

ctctcagctc ggccagggca atctcaaagt ccgctttaag aaggtccctc acaacatcaa     2760

cttccgtgag aagaagccaa agccatccaa gaagaaagca gaaggtggcg gcgcagagga     2820

gggggctggg gcccggggcc gcgtggcgcg tttccgctac ttcgaggata tttatggcta     2880

ctcaggggtc ttcatctgcg gcccctcccc tcactggctc ttggtgaccg gccgaggggc     2940

tctgcggcta caccccatgg ccatcgacgg cccggtcgac tctttcgctc cattccacaa     3000

tgtcaactgt ccccgcggct tcctgtactt caacagacag ggcgagctga ggatcagtgt     3060

cctgcctgcc tacctgtcct atgatgcccc atggcctgtc aggaagatcc cgctgcgctg     3120

cacggcccac tatgtggctt accacgtgga gtctaaggtg tatgctgtgg ccaccagcac     3180

caacacgccg tgtgcccgca tcccacgcat gactggcgag gagaaggagt ttgagaccat     3240

cgagagagat gagcggtaca tccaccccca gcaggaggcc ttctccatcc agctcatctc     3300

cccggtcagc tgggaggcta ttcccaatgc caggatcgag ctgcaggagt gggagcatgt     3360

gacctgcatg aagacagtgt ctctgcgcag tgaggagacc gtgtcgggcc tcaaaggcta     3420

cgtggccgcc gggacctgcc tcatgcaggg ggaggaggtc acgtgccgag ggcggatctt     3480

gatcatggat gtgattgagg tggtgcccga gcctggccag cccttgacca agaacaagtt     3540

caaagtcctt tacgagaagg agcagaaggg gcccgtgacc gccctgtgcc actgcaatgg     3600

ccacctggtg tcggccatcg gccagaagat tttcctgtgg agcctgcggg ccagcgagct     3660

gacgggcatg gccttcatcg acacgcagct ctacatacac cagatgatca gcgtcaagaa     3720

cttcatcctg gcagccgacg tcatgaagag catttcgctg ctgcgctacc aggaggaaag     3780

caagacgctg agcctggtgt cgcgggatgc caagcccctg gaggtgtaca gcgtggactt     3840

catggtggac aatgcccagc tgggttttct ggtgtctgac cgcgaccgca acctcatggt     3900

gtacatgtac ctgcccgaag ccaaggagag tttcgggggc atgcgcctgc tgcgtcgggc     3960

agacttccac gtgggtgccc acgtgaacac gttctggagg accccgtgcc ggggggccac     4020

tgaagggctc agcaaaaagt cggtcgtgtg ggagaataag cacatcacgt ggtttgccac     4080

cctggacggc ggcatcgggc tgctgctgcc catgcaggag aagacctacc ggcggctgct     4140

gatgctgcag aacgcgctga ccaccatgct gccacaccac gccggcctca acccccgcgc     4200

cttccggatg ctgcacgtgg accgccgcac cctccagaat gccgtgcgca acgtgctgga     4260

tggggagctg ctcaaccgct acctgtacct gagcaccatg gagcgcagcg agctagccaa     4320

gaagatcggc accacaccag acataatcct ggacgacttg ctggagacgg accgcgtcac     4380

cgcccacttc tagccccgtg gatgccgtca ccaccagcac acggaactac ctcccacccc     4440

ctttttgtac aaaacacaag gaaaaacatt ttttgcttga                           4480


<210>  20
<211>  1443
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Tyr Ala Val Tyr Lys Gln Ala His Pro Pro Thr Gly Leu Glu Phe 
1               5                   10                  15      


Ser Met Tyr Cys Asn Phe Phe Asn Asn Ser Glu Arg Asn Leu Val Val 
            20                  25                  30          


Ala Gly Thr Ser Gln Leu Tyr Val Tyr Arg Leu Asn Arg Asp Ala Glu 
        35                  40                  45              


Ala Leu Thr Lys Asn Asp Arg Ser Thr Glu Gly Lys Ala His Arg Glu 
    50                  55                  60                  


Lys Leu Glu Leu Ala Ala Ser Phe Ser Phe Phe Gly Asn Val Met Ser 
65                  70                  75                  80  


Met Ala Ser Val Gln Leu Ala Gly Ala Lys Arg Asp Ala Leu Leu Leu 
                85                  90                  95      


Ser Phe Lys Asp Ala Lys Leu Ser Val Val Glu Tyr Asp Pro Gly Thr 
            100                 105                 110         


His Asp Leu Lys Thr Leu Ser Leu His Tyr Phe Glu Glu Pro Glu Leu 
        115                 120                 125             


Arg Asp Gly Phe Val Gln Asn Val His Thr Pro Arg Val Arg Val Asp 
    130                 135                 140                 


Pro Asp Gly Arg Cys Ala Ala Met Leu Val Tyr Gly Thr Arg Leu Val 
145                 150                 155                 160 


Val Leu Pro Phe Arg Arg Glu Ser Leu Ala Glu Glu His Glu Gly Leu 
                165                 170                 175     


Val Gly Glu Gly Gln Arg Ser Ser Phe Leu Pro Ser Tyr Ile Ile Asp 
            180                 185                 190         


Val Arg Ala Leu Asp Glu Lys Leu Leu Asn Ile Ile Asp Leu Gln Phe 
        195                 200                 205             


Leu His Gly Tyr Tyr Glu Pro Thr Leu Leu Ile Leu Phe Glu Pro Asn 
    210                 215                 220                 


Gln Thr Trp Pro Gly Arg Val Ala Val Arg Gln Asp Thr Cys Ser Ile 
225                 230                 235                 240 


Val Ala Ile Ser Leu Asn Ile Thr Gln Lys Val His Pro Val Ile Trp 
                245                 250                 255     


Ser Leu Thr Ser Leu Pro Phe Asp Cys Thr Gln Ala Leu Ala Val Pro 
            260                 265                 270         


Lys Pro Ile Gly Gly Val Val Val Phe Ala Val Asn Ser Leu Leu Tyr 
        275                 280                 285             


Leu Asn Gln Ser Val Pro Pro Tyr Gly Val Ala Leu Asn Ser Leu Thr 
    290                 295                 300                 


Thr Gly Thr Thr Ala Phe Pro Leu Arg Thr Gln Glu Gly Val Arg Ile 
305                 310                 315                 320 


Thr Leu Asp Cys Ala Gln Ala Thr Phe Ile Ser Tyr Asp Lys Met Val 
                325                 330                 335     


Ile Ser Leu Lys Gly Gly Glu Ile Tyr Val Leu Thr Leu Ile Thr Asp 
            340                 345                 350         


Gly Met Arg Ser Val Arg Ala Phe His Phe Asp Lys Ala Ala Ala Ser 
        355                 360                 365             


Val Leu Thr Thr Ser Met Val Thr Met Glu Pro Gly Tyr Leu Phe Leu 
    370                 375                 380                 


Gly Ser Arg Leu Gly Asn Ser Leu Leu Leu Lys Tyr Thr Glu Lys Leu 
385                 390                 395                 400 


Gln Glu Pro Pro Ala Ser Ala Val Arg Glu Ala Ala Asp Lys Glu Glu 
                405                 410                 415     


Pro Pro Ser Lys Lys Lys Arg Val Asp Ala Thr Ala Gly Trp Ser Ala 
            420                 425                 430         


Ala Gly Lys Ser Val Pro Gln Asp Glu Val Asp Glu Ile Glu Val Tyr 
        435                 440                 445             


Gly Ser Glu Ala Gln Ser Gly Thr Gln Leu Ala Thr Tyr Ser Phe Glu 
    450                 455                 460                 


Val Cys Asp Ser Ile Leu Asn Ile Gly Pro Cys Ala Asn Ala Ala Val 
465                 470                 475                 480 


Gly Glu Pro Ala Phe Leu Ser Glu Glu Phe Gln Asn Ser Pro Glu Pro 
                485                 490                 495     


Asp Leu Glu Ile Val Val Cys Ser Gly His Gly Lys Asn Gly Ala Leu 
            500                 505                 510         


Ser Val Leu Gln Lys Ser Ile Arg Pro Gln Val Val Thr Thr Phe Glu 
        515                 520                 525             


Leu Pro Gly Cys Tyr Asp Met Trp Thr Val Ile Ala Pro Val Arg Lys 
    530                 535                 540                 


Glu Glu Glu Asp Asn Pro Lys Gly Glu Gly Thr Glu Gln Glu Pro Ser 
545                 550                 555                 560 


Thr Thr Pro Glu Ala Asp Asp Asp Gly Arg Arg His Gly Phe Leu Ile 
                565                 570                 575     


Leu Ser Arg Glu Asp Ser Thr Met Ile Leu Gln Thr Gly Gln Glu Ile 
            580                 585                 590         


Met Glu Leu Asp Thr Ser Gly Phe Ala Thr Gln Gly Pro Thr Val Phe 
        595                 600                 605             


Ala Gly Asn Ile Gly Asp Asn Arg Tyr Ile Val Gln Val Ser Pro Leu 
    610                 615                 620                 


Gly Ile Arg Leu Leu Glu Gly Val Asn Gln Leu His Phe Ile Pro Val 
625                 630                 635                 640 


Asp Leu Gly Ala Pro Ile Val Gln Cys Ala Val Ala Asp Pro Tyr Val 
                645                 650                 655     


Val Ile Met Ser Ala Glu Gly His Val Thr Met Phe Leu Leu Lys Ser 
            660                 665                 670         


Asp Ser Tyr Gly Gly Arg His His Arg Leu Ala Leu His Lys Pro Pro 
        675                 680                 685             


Leu His His Gln Ser Lys Val Ile Thr Leu Cys Leu Tyr Arg Asp Leu 
    690                 695                 700                 


Ser Gly Met Phe Thr Thr Glu Ser Arg Leu Gly Gly Ala Arg Asp Glu 
705                 710                 715                 720 


Leu Gly Gly Arg Ser Gly Pro Glu Ala Glu Gly Leu Gly Ser Glu Thr 
                725                 730                 735     


Ser Pro Thr Val Asp Asp Glu Glu Glu Met Leu Tyr Gly Asp Ser Gly 
            740                 745                 750         


Ser Leu Phe Ser Pro Ser Lys Glu Glu Ala Arg Arg Ser Ser Gln Pro 
        755                 760                 765             


Pro Ala Asp Arg Asp Pro Ala Pro Phe Arg Ala Glu Pro Thr His Trp 
    770                 775                 780                 


Cys Leu Leu Val Arg Glu Asn Gly Thr Met Glu Ile Tyr Gln Leu Pro 
785                 790                 795                 800 


Asp Trp Arg Leu Val Phe Leu Val Lys Asn Phe Pro Val Gly Gln Arg 
                805                 810                 815     


Val Leu Val Asp Ser Ser Phe Gly Gln Pro Thr Thr Gln Gly Glu Ala 
            820                 825                 830         


Arg Arg Glu Glu Ala Thr Arg Gln Gly Glu Leu Pro Leu Val Lys Glu 
        835                 840                 845             


Val Leu Leu Val Ala Leu Gly Ser Arg Gln Ser Arg Pro Tyr Leu Leu 
    850                 855                 860                 


Val His Val Asp Gln Glu Leu Leu Ile Tyr Glu Ala Phe Pro His Asp 
865                 870                 875                 880 


Ser Gln Leu Gly Gln Gly Asn Leu Lys Val Arg Phe Lys Lys Val Pro 
                885                 890                 895     


His Asn Ile Asn Phe Arg Glu Lys Lys Pro Lys Pro Ser Lys Lys Lys 
            900                 905                 910         


Ala Glu Gly Gly Gly Ala Glu Glu Gly Ala Gly Ala Arg Gly Arg Val 
        915                 920                 925             


Ala Arg Phe Arg Tyr Phe Glu Asp Ile Tyr Gly Tyr Ser Gly Val Phe 
    930                 935                 940                 


Ile Cys Gly Pro Ser Pro His Trp Leu Leu Val Thr Gly Arg Gly Ala 
945                 950                 955                 960 


Leu Arg Leu His Pro Met Ala Ile Asp Gly Pro Val Asp Ser Phe Ala 
                965                 970                 975     


Pro Phe His Asn Val Asn Cys Pro Arg Gly Phe Leu Tyr Phe Asn Arg 
            980                 985                 990         


Gln Gly Glu Leu Arg Ile Ser Val  Leu Pro Ala Tyr Leu  Ser Tyr Asp 
        995                 1000                 1005             


Ala Pro  Trp Pro Val Arg Lys  Ile Pro Leu Arg Cys  Thr Ala His 
    1010                 1015                 1020             


Tyr Val  Ala Tyr His Val Glu  Ser Lys Val Tyr Ala  Val Ala Thr 
    1025                 1030                 1035             


Ser Thr  Asn Thr Pro Cys Ala  Arg Ile Pro Arg Met  Thr Gly Glu 
    1040                 1045                 1050             


Glu Lys  Glu Phe Glu Thr Ile  Glu Arg Asp Glu Arg  Tyr Ile His 
    1055                 1060                 1065             


Pro Gln  Gln Glu Ala Phe Ser  Ile Gln Leu Ile Ser  Pro Val Ser 
    1070                 1075                 1080             


Trp Glu  Ala Ile Pro Asn Ala  Arg Ile Glu Leu Gln  Glu Trp Glu 
    1085                 1090                 1095             


His Val  Thr Cys Met Lys Thr  Val Ser Leu Arg Ser  Glu Glu Thr 
    1100                 1105                 1110             


Val Ser  Gly Leu Lys Gly Tyr  Val Ala Ala Gly Thr  Cys Leu Met 
    1115                 1120                 1125             


Gln Gly  Glu Glu Val Thr Cys  Arg Gly Arg Ile Leu  Ile Met Asp 
    1130                 1135                 1140             


Val Ile  Glu Val Val Pro Glu  Pro Gly Gln Pro Leu  Thr Lys Asn 
    1145                 1150                 1155             


Lys Phe  Lys Val Leu Tyr Glu  Lys Glu Gln Lys Gly  Pro Val Thr 
    1160                 1165                 1170             


Ala Leu  Cys His Cys Asn Gly  His Leu Val Ser Ala  Ile Gly Gln 
    1175                 1180                 1185             


Lys Ile  Phe Leu Trp Ser Leu  Arg Ala Ser Glu Leu  Thr Gly Met 
    1190                 1195                 1200             


Ala Phe  Ile Asp Thr Gln Leu  Tyr Ile His Gln Met  Ile Ser Val 
    1205                 1210                 1215             


Lys Asn  Phe Ile Leu Ala Ala  Asp Val Met Lys Ser  Ile Ser Leu 
    1220                 1225                 1230             


Leu Arg  Tyr Gln Glu Glu Ser  Lys Thr Leu Ser Leu  Val Ser Arg 
    1235                 1240                 1245             


Asp Ala  Lys Pro Leu Glu Val  Tyr Ser Val Asp Phe  Met Val Asp 
    1250                 1255                 1260             


Asn Ala  Gln Leu Gly Phe Leu  Val Ser Asp Arg Asp  Arg Asn Leu 
    1265                 1270                 1275             


Met Val  Tyr Met Tyr Leu Pro  Glu Ala Lys Glu Ser  Phe Gly Gly 
    1280                 1285                 1290             


Met Arg  Leu Leu Arg Arg Ala  Asp Phe His Val Gly  Ala His Val 
    1295                 1300                 1305             


Asn Thr  Phe Trp Arg Thr Pro  Cys Arg Gly Ala Thr  Glu Gly Leu 
    1310                 1315                 1320             


Ser Lys  Lys Ser Val Val Trp  Glu Asn Lys His Ile  Thr Trp Phe 
    1325                 1330                 1335             


Ala Thr  Leu Asp Gly Gly Ile  Gly Leu Leu Leu Pro  Met Gln Glu 
    1340                 1345                 1350             


Lys Thr  Tyr Arg Arg Leu Leu  Met Leu Gln Asn Ala  Leu Thr Thr 
    1355                 1360                 1365             


Met Leu  Pro His His Ala Gly  Leu Asn Pro Arg Ala  Phe Arg Met 
    1370                 1375                 1380             


Leu His  Val Asp Arg Arg Thr  Leu Gln Asn Ala Val  Arg Asn Val 
    1385                 1390                 1395             


Leu Asp  Gly Glu Leu Leu Asn  Arg Tyr Leu Tyr Leu  Ser Thr Met 
    1400                 1405                 1410             


Glu Arg  Ser Glu Leu Ala Lys  Lys Ile Gly Thr Thr  Pro Asp Ile 
    1415                 1420                 1425             


Ile Leu  Asp Asp Leu Leu Glu  Thr Asp Arg Val Thr  Ala His Phe 
    1430                 1435                 1440             


<210>  21
<211>  2086
<212>  DNA
<213>  Homo sapiens

<400>  21
ggagacgcaa gatggcggct gtggtgctgg cggcgacgcg gttgctgcgg ggctcgggtt       60

cttggggctg ttcgcggctg aggtttggac ctcctgcgta cagacggttt agtagtggtg      120

gtgcctatcc caacatcccc ctctcttctc ccttacctgg agtacccaag cctgtttttg      180

ctacagttga tggacaggaa aagtttgaaa ccaaagtaac cacattggat aatgggcttc      240

gcgtggcatc tcagaataag tttggacagt tttgtacagt aggaattctt atcaattcag      300

gatcgagata tgaagcgaaa taccttagtg gaattgctca ctttttggaa aaattggcat      360

tttcgtctac tgctcgattt gacagcaaag atgaaattct gcttacgttg gaaaagcatg      420

ggggtatctg tgactgccag acatcaagag acaccaccat gtatgctgtg tctgctgata      480

gcaaaggctt ggacacggtg gttgccttac tggctgatgt ggttctgcag ccccggctaa      540

cagatgaaga agtcgagatg acgcggatgg cggtccagtt tgagctggag gacctgaacc      600

tgcggcctga cccagagcca cttctcaccg agatgattca tgaagcggct tacagggaga      660

acacagttgg cctccaccgt ttctgcccca cagaaaacgt agcaaagatc aaccgagagg      720

tgctgcattc ctacctgagg aactactaca ctcccgaccg catggtgctg gccggcgtgg      780

gcgtggagca cgagcatctg gtggactgtg cccggaagta cctcctgggg gtccagccgg      840

cctgggggag cgcagaggcc gtggatattg acagatctgt ggcccagtac actgggggga      900

ttgccaagct agaaagagac atgtccaatg tcagcctggg cccgaccccc atccccgagc      960

tcacgcacat catggttgga ctggagagct gctccttcct ggaggaggac ttcatcccct     1020

ttgcagtgtt gaacatgatg atgggcggag gtggctcctt ctcggctggt gggcccggca     1080

agggcatgtt ctccaggctc tacctcaacg tgctcaacag gcaccactgg atgtataacg     1140

cgacctccta ccaccacagc tacgaggaca ctggcctcct ttgcatccat gccagcgccg     1200

acccaagaca ggttcgagaa atggtagaaa tcatcacaaa ggagtttatt ttaatgggcg     1260

gaaccgtgga cacggtggag ctggaacgag ccaagacgca gctgacatca atgctcatga     1320

tgaacctgga atccaggcct gtgatcttcg aggatgtggg gaggcaggtg ctggccactc     1380

gctccagaaa gctgccgcac gagctgtgca cgctcatccg caacgtgaag ccggaagatg     1440

tgaagagagt cgcttctaag atgctccgag ggaagccggc agtggccgcc ctgggtgacc     1500

tgactgacct gcccacgtat gagcacatcc agaccgccct gtcgagtaag gacgggcgcc     1560

tgcccaggac gtaccggctc ttccggtaga accgctcccc ggcctgacag acccagggag     1620

ctgcagctgg agcccgttcc cgtgcgtgtt agtttggaca cgaatttagt ctaaaaagct     1680

gtctggttgt ataaacggtg caaacaatgt cgccacagca cccacgcggt ttgcattctt     1740

ttggaactca atgtgccgat cagtggagtc agtatcgagc ctgaccaccg caagccagga     1800

agcaggtgaa gtgcccagcg ctggagtgca gcgtgccacg aggagggcgg tcggtgcttc     1860

cctcctcggg ctgtgggcac atggggcccc gcaggttcct tggaggagcc ctgagctggg     1920

aggcagcaaa ggctgaccta tcaaagcctc ccggaggcca ccgtgctggg taccaggact     1980

cacctctgac aagcaggaga aggtaagggc ccggtcagct ccaaggagcg cgctccacgc     2040

gcgtgcacac agcttccctg gtaataaaga gctggcatct ttctta                    2086


<210>  22
<211>  525
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ala Val Val Leu Ala Ala Thr Arg Leu Leu Arg Gly Ser Gly 
1               5                   10                  15      


Ser Trp Gly Cys Ser Arg Leu Arg Phe Gly Pro Pro Ala Tyr Arg Arg 
            20                  25                  30          


Phe Ser Ser Gly Gly Ala Tyr Pro Asn Ile Pro Leu Ser Ser Pro Leu 
        35                  40                  45              


Pro Gly Val Pro Lys Pro Val Phe Ala Thr Val Asp Gly Gln Glu Lys 
    50                  55                  60                  


Phe Glu Thr Lys Val Thr Thr Leu Asp Asn Gly Leu Arg Val Ala Ser 
65                  70                  75                  80  


Gln Asn Lys Phe Gly Gln Phe Cys Thr Val Gly Ile Leu Ile Asn Ser 
                85                  90                  95      


Gly Ser Arg Tyr Glu Ala Lys Tyr Leu Ser Gly Ile Ala His Phe Leu 
            100                 105                 110         


Glu Lys Leu Ala Phe Ser Ser Thr Ala Arg Phe Asp Ser Lys Asp Glu 
        115                 120                 125             


Ile Leu Leu Thr Leu Glu Lys His Gly Gly Ile Cys Asp Cys Gln Thr 
    130                 135                 140                 


Ser Arg Asp Thr Thr Met Tyr Ala Val Ser Ala Asp Ser Lys Gly Leu 
145                 150                 155                 160 


Asp Thr Val Val Ala Leu Leu Ala Asp Val Val Leu Gln Pro Arg Leu 
                165                 170                 175     


Thr Asp Glu Glu Val Glu Met Thr Arg Met Ala Val Gln Phe Glu Leu 
            180                 185                 190         


Glu Asp Leu Asn Leu Arg Pro Asp Pro Glu Pro Leu Leu Thr Glu Met 
        195                 200                 205             


Ile His Glu Ala Ala Tyr Arg Glu Asn Thr Val Gly Leu His Arg Phe 
    210                 215                 220                 


Cys Pro Thr Glu Asn Val Ala Lys Ile Asn Arg Glu Val Leu His Ser 
225                 230                 235                 240 


Tyr Leu Arg Asn Tyr Tyr Thr Pro Asp Arg Met Val Leu Ala Gly Val 
                245                 250                 255     


Gly Val Glu His Glu His Leu Val Asp Cys Ala Arg Lys Tyr Leu Leu 
            260                 265                 270         


Gly Val Gln Pro Ala Trp Gly Ser Ala Glu Ala Val Asp Ile Asp Arg 
        275                 280                 285             


Ser Val Ala Gln Tyr Thr Gly Gly Ile Ala Lys Leu Glu Arg Asp Met 
    290                 295                 300                 


Ser Asn Val Ser Leu Gly Pro Thr Pro Ile Pro Glu Leu Thr His Ile 
305                 310                 315                 320 


Met Val Gly Leu Glu Ser Cys Ser Phe Leu Glu Glu Asp Phe Ile Pro 
                325                 330                 335     


Phe Ala Val Leu Asn Met Met Met Gly Gly Gly Gly Ser Phe Ser Ala 
            340                 345                 350         


Gly Gly Pro Gly Lys Gly Met Phe Ser Arg Leu Tyr Leu Asn Val Leu 
        355                 360                 365             


Asn Arg His His Trp Met Tyr Asn Ala Thr Ser Tyr His His Ser Tyr 
    370                 375                 380                 


Glu Asp Thr Gly Leu Leu Cys Ile His Ala Ser Ala Asp Pro Arg Gln 
385                 390                 395                 400 


Val Arg Glu Met Val Glu Ile Ile Thr Lys Glu Phe Ile Leu Met Gly 
                405                 410                 415     


Gly Thr Val Asp Thr Val Glu Leu Glu Arg Ala Lys Thr Gln Leu Thr 
            420                 425                 430         


Ser Met Leu Met Met Asn Leu Glu Ser Arg Pro Val Ile Phe Glu Asp 
        435                 440                 445             


Val Gly Arg Gln Val Leu Ala Thr Arg Ser Arg Lys Leu Pro His Glu 
    450                 455                 460                 


Leu Cys Thr Leu Ile Arg Asn Val Lys Pro Glu Asp Val Lys Arg Val 
465                 470                 475                 480 


Ala Ser Lys Met Leu Arg Gly Lys Pro Ala Val Ala Ala Leu Gly Asp 
                485                 490                 495     


Leu Thr Asp Leu Pro Thr Tyr Glu His Ile Gln Thr Ala Leu Ser Ser 
            500                 505                 510         


Lys Asp Gly Arg Leu Pro Arg Thr Tyr Arg Leu Phe Arg 
        515                 520                 525 


<210>  23
<211>  5359
<212>  DNA
<213>  Homo sapiens

<400>  23
gttctgaatg atgactgacg cgggtttggg tgatacccct cacagcccct gtcattccgg       60

agtcataagg cacccgcgcg tctagcccca gcgccagggc acgcgagcgg cgctggaggg      120

aggaaagctt ccgcctgcgg gccggacaaa agtcccgcct gcccacggct ttttgcccgc      180

cgctcgtgac cgagacgcct cgccgcggcc agctcgctgc tctcgctggc ggatggtgtg      240

tggccgccgc aggacgcccg ccgtgcccgg gccatgaagt agcggctgct ggcggcgccg      300

ctgcccaacc gccagcccca gccccgcgct gcgctgcccg gtcctctccc ggcggggtcg      360

tatcggcgtg gacatggctg gccgcgtccc tagcctgcta gttctccttg tttttccaag      420

cagctgtttg gctttccgaa gcccactttc tgtctttaag aggtttaaag aaactaccag      480

accattttcc aatgaatgtc ttggtaccac cagacccgta gttcctattg attcatcaga      540

ttttgcattg gatattcgca tgcctggggt tacacctaaa cagtccgata catacttctg      600

catgtctatg cgaataccag tggatgagga agccttcgtg attgacttca agcctcgagc      660

cagcatggat actgtccatc acatgttact ttttggatgc aatatgcctt catccactgg      720

aagttactgg ttttgtgatg aaggaacctg tacagataaa gccaatattc tgtatgcctg      780

ggcgagaaat gctcccccta cccggctccc caaaggtgtt ggattcagag ttggaggaga      840

gactggaagt aaatactttg tactacaggt acactatggg gatattagtg cttttagaga      900

taataacaag gactgttctg gtgtgtcctt acacctcaca cgtctgccac agcctttaat      960

tgctggcatg taccttatga tgtctgttga cactgttatc ccagcaggag aaaaagtggt     1020

gaattctgac atttcatgcc attataaaaa ttatccaatg catgtctttg cctatagagt     1080

tcacactcac catttaggta aggtagtaag tggatacaga gtaagaaatg gacagtggac     1140

actgattgga cggcagagcc ctcagctgcc acaggctttc taccctgtgg ggcatccagt     1200

tgatgtaagt tttggtgacc tactggctgc aagatgtgta ttcactggtg aaggaaggac     1260

agaagccaca cacattggtg gcacgtctag tgatgaaatg tgcaacttat acattatgta     1320

ttacatggaa gccaagcatg cagtttcttt catgacctgt acccagaatg tagctccaga     1380

tatgttcaga accataccac cagaggccaa cattccaatt cccgtgaagt ctgatatggt     1440

tatgatgcat gaacatcata aagaaacaga atataaagat aagattcctt tactacagca     1500

gccaaaacga gaagaagaag aagtgttaga ccagggtgat ttctattcac tactttccaa     1560

gctgctagga gaaagggaag atgttgttca tgtgcacaaa tataatccta cagaaaaggc     1620

agaatcagag tcagacctgg tagctgagat tgcaaatgta gtccaaaaaa aggatcttgg     1680

tcgatctgat gccagagagg gtgcagaaca tgagaggggt aatgctattc ttgtcagaga     1740

cagaattcac aaattccaca gactagtatc taccttgagg ccaccagaga gcagagtttt     1800

ctcattacag cagcccccac ctggtgaagg cacctgggaa ccagaacaca caggagattt     1860

ccacatggaa gaggcactgg attggcctgg agtatacttg ttaccaggcc aggtttctgg     1920

ggtggctcta gaccctaaga ataacctggt gattttccac agaggtgacc atgtctggga     1980

tggaaactcg tttgacagca agtttgttta ccagcaaata ggactcggac caattgaaga     2040

agacactatt cttgtcatag atccaaataa tgctgcagta ctccagtcca gtggaaaaaa     2100

tctgttttac ttgccacatg gcttgagtat agataaagat gggaattatt gggtcacaga     2160

cgtggctctc catcaggtgt tcaaactgga tccaaacaat aaagaaggcc ctgtattaat     2220

cctgggaagg agcatgcaac caggcagtga ccagaatcac ttctgtcaac ccactgatgt     2280

ggctgtggat ccaggcactg gagccattta tgtatcagat ggttactgca acagcaggat     2340

tgtgcagttt tcaccaagtg gaaagttcat cacacagtgg ggagaagagt cttcagggag     2400

cagtcctctg ccaggccagt tcactgttcc tcacagcttg gctcttgtgc ctcttttggg     2460

ccaattatgt gtggcagacc gggaaaatgg tcggatccag tgttttaaaa ctgacaccaa     2520

agaatttgtg agagagatta agcattcatc atttggaaga aatgtatttg caatttcata     2580

tataccaggc ttgctctttg cagtgaatgg gaagcctcat tttggggacc aagaacctgt     2640

acaaggattt gtgatgaact tttccaatgg ggaaattata gacatcttca agccagtgcg     2700

caagcacttt gatatgcctc atgatattgt tgcatctgaa gatgggactg tgtacattgg     2760

agatgctcat accaacaccg tgtggaagtt caccttgact gagaaattgg aacatcgatc     2820

agttaaaaag gctggcattg aggtccagga aatcaaagaa gccgaggcag ttgttgaaac     2880

caaaatggag aacaaaccca cctcctcaga attgcagaag atgcaagaga aacagaaact     2940

gatcaaagag ccaggctcgg gagtgcctgt tgttctcatt acaacccttc tggttattcc     3000

ggtggttgtc ctgctggcca ttgccatatt tattcggtgg aaaaaatcaa gggcctttgg     3060

agcagattct gaacacaaac tcgagacgag ttcaggaaga gtactgggaa gatttagagg     3120

aaagggaagt ggaggcttaa accttggtaa tttctttgca agccgtaagg gctacagtcg     3180

aaaagggttt gaccggctta gcactgaggg cagtgaccaa gagaaagagg atgatggaag     3240

tgaatcagaa gaggagtatt cagcacctct gcctgcgctc gcaccttcct cctcctgaaa     3300

accaagcttt gatttagatt gagtaagatt tacccagaat gtcagattcc tttcccttta     3360

gcacgtttaa agttctgtgt atttaattgt aaactgtact agtctgtgtg ggactgtaca     3420

cactttattt acttcgtttt ggttaagttg gcttctgttt ctagttgagg agtttcctaa     3480

aagttcataa cagtgccatt gtctttatat gaacatagac tagagaaacc gtcctctttt     3540

tccatcataa ttctaatcta acaatggaag atttgcccat ttacactttt gagacttttt     3600

ggtggatgta aataacccca ttctttgctt gaacacagta ttttcccaat agcactttca     3660

ttgccagtgt ctttctttgg tgcctttcct gttcagcatt cttagcctgt ggcagtaaag     3720

agaaactttg tgctacatga cgacaaagct gctaaatctc ctattttttt aaaatcacta     3780

acattatatt gcaatgaagg aaataaaaaa gtctctattt aaattctttt ttaaattttc     3840

ttcagttggt gtgtttttgg gatgtcttat ttttagatgg ttacactgtt agaacactat     3900

tttcagaatc tgaatgtaat ttgtgtaata aagtgttttc agagcattag ctgtcagtgt     3960

attttccagt ttttgcgtat ttgcagattt tacatacaac ttttataata attacacaaa     4020

cccacaaata ttagtgaaac ttactcgatg tcttcaacta aaagaaatgt gtgtattgta     4080

caaaatttag aagatacttt agccaatata aattaaaaac cagcctgagt ttacataaat     4140

ttgtaaagtc aggctcttct aaaatccaaa gagggttttt gcctatatat caatcagagg     4200

ataaatactt taataaaagg taatcacagc taagtggata cctgtgtctc aaattacata     4260

tgcaaatgat ccatcagtag ggatcactaa taatagtttt ccttttaaaa aataatttca     4320

gggcaggtac agtggctcaa gcctatactt ccaggacttt gggaggccaa gcagaaggat     4380

tgtgggaggc caagcagaag gattgtttga gcccagaaat tcaaggctgc agtgagctat     4440

gatcaatcca ctgtactcca gcctaggcta cagagtgaga tcctttctct aaaataaaat     4500

acaatttcca tgtatccata ggaatatatt catcttttac agtgattgca gattagtttt     4560

aaaacgtctt tttcgtaatt cgtcaatgca agttagtaag aaccagataa ttttccattt     4620

taaaatgata ggaatctaaa actctttttc aaaaatgcca acctgttttt ccggcatcat     4680

agtagttgga ataatacaga tataattgac taatcataaa gtacatgaga gtacagaagg     4740

gaaatttgga aacggtaagt ctgctagggc attacaatcc tgtcctagca ctccaccttt     4800

attctgccaa cctgggttaa ttaaagatgg tagcctggaa agtaatgaat gacattgact     4860

tcaggcaatc tttccactga ttattcttgg ctgaacttca tttatcgagt cagagaatgc     4920

actgcctgag aaatgtccca gaggagtgaa tcctaggcct ggccacagta gaatcgcctg     4980

gagaatttaa gaaaaaaatt gttgggcact cactctttcc agtgatcttt atttagttgg     5040

cttacaatgg aatacaggta tggttcatgt ttttaaattt gtccaggtgt ttctattgtg     5100

cagtcacagt tgaaaaccat tgtcttcgag aatagctatt ctatcttgcc agttacaata     5160

agtggatagc tatattttca cataaattat agtttacaga tgtttggagg gggaagacag     5220

gatctgaggt gttttgatat gactgttagc accaaaatct gaatgcctta attgttgaat     5280

gtgttaaatt ggataattaa aatgggcata aatgacttat taaaaaagca aagggaaaaa     5340

aaaaaaaaaa aaaaaaaaa                                                  5359


<210>  24
<211>  974
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Gly Arg Val Pro Ser Leu Leu Val Leu Leu Val Phe Pro Ser 
1               5                   10                  15      


Ser Cys Leu Ala Phe Arg Ser Pro Leu Ser Val Phe Lys Arg Phe Lys 
            20                  25                  30          


Glu Thr Thr Arg Pro Phe Ser Asn Glu Cys Leu Gly Thr Thr Arg Pro 
        35                  40                  45              


Val Val Pro Ile Asp Ser Ser Asp Phe Ala Leu Asp Ile Arg Met Pro 
    50                  55                  60                  


Gly Val Thr Pro Lys Gln Ser Asp Thr Tyr Phe Cys Met Ser Met Arg 
65                  70                  75                  80  


Ile Pro Val Asp Glu Glu Ala Phe Val Ile Asp Phe Lys Pro Arg Ala 
                85                  90                  95      


Ser Met Asp Thr Val His His Met Leu Leu Phe Gly Cys Asn Met Pro 
            100                 105                 110         


Ser Ser Thr Gly Ser Tyr Trp Phe Cys Asp Glu Gly Thr Cys Thr Asp 
        115                 120                 125             


Lys Ala Asn Ile Leu Tyr Ala Trp Ala Arg Asn Ala Pro Pro Thr Arg 
    130                 135                 140                 


Leu Pro Lys Gly Val Gly Phe Arg Val Gly Gly Glu Thr Gly Ser Lys 
145                 150                 155                 160 


Tyr Phe Val Leu Gln Val His Tyr Gly Asp Ile Ser Ala Phe Arg Asp 
                165                 170                 175     


Asn Asn Lys Asp Cys Ser Gly Val Ser Leu His Leu Thr Arg Leu Pro 
            180                 185                 190         


Gln Pro Leu Ile Ala Gly Met Tyr Leu Met Met Ser Val Asp Thr Val 
        195                 200                 205             


Ile Pro Ala Gly Glu Lys Val Val Asn Ser Asp Ile Ser Cys His Tyr 
    210                 215                 220                 


Lys Asn Tyr Pro Met His Val Phe Ala Tyr Arg Val His Thr His His 
225                 230                 235                 240 


Leu Gly Lys Val Val Ser Gly Tyr Arg Val Arg Asn Gly Gln Trp Thr 
                245                 250                 255     


Leu Ile Gly Arg Gln Ser Pro Gln Leu Pro Gln Ala Phe Tyr Pro Val 
            260                 265                 270         


Gly His Pro Val Asp Val Ser Phe Gly Asp Leu Leu Ala Ala Arg Cys 
        275                 280                 285             


Val Phe Thr Gly Glu Gly Arg Thr Glu Ala Thr His Ile Gly Gly Thr 
    290                 295                 300                 


Ser Ser Asp Glu Met Cys Asn Leu Tyr Ile Met Tyr Tyr Met Glu Ala 
305                 310                 315                 320 


Lys His Ala Val Ser Phe Met Thr Cys Thr Gln Asn Val Ala Pro Asp 
                325                 330                 335     


Met Phe Arg Thr Ile Pro Pro Glu Ala Asn Ile Pro Ile Pro Val Lys 
            340                 345                 350         


Ser Asp Met Val Met Met His Glu His His Lys Glu Thr Glu Tyr Lys 
        355                 360                 365             


Asp Lys Ile Pro Leu Leu Gln Gln Pro Lys Arg Glu Glu Glu Glu Val 
    370                 375                 380                 


Leu Asp Gln Gly Asp Phe Tyr Ser Leu Leu Ser Lys Leu Leu Gly Glu 
385                 390                 395                 400 


Arg Glu Asp Val Val His Val His Lys Tyr Asn Pro Thr Glu Lys Ala 
                405                 410                 415     


Glu Ser Glu Ser Asp Leu Val Ala Glu Ile Ala Asn Val Val Gln Lys 
            420                 425                 430         


Lys Asp Leu Gly Arg Ser Asp Ala Arg Glu Gly Ala Glu His Glu Arg 
        435                 440                 445             


Gly Asn Ala Ile Leu Val Arg Asp Arg Ile His Lys Phe His Arg Leu 
    450                 455                 460                 


Val Ser Thr Leu Arg Pro Pro Glu Ser Arg Val Phe Ser Leu Gln Gln 
465                 470                 475                 480 


Pro Pro Pro Gly Glu Gly Thr Trp Glu Pro Glu His Thr Gly Asp Phe 
                485                 490                 495     


His Met Glu Glu Ala Leu Asp Trp Pro Gly Val Tyr Leu Leu Pro Gly 
            500                 505                 510         


Gln Val Ser Gly Val Ala Leu Asp Pro Lys Asn Asn Leu Val Ile Phe 
        515                 520                 525             


His Arg Gly Asp His Val Trp Asp Gly Asn Ser Phe Asp Ser Lys Phe 
    530                 535                 540                 


Val Tyr Gln Gln Ile Gly Leu Gly Pro Ile Glu Glu Asp Thr Ile Leu 
545                 550                 555                 560 


Val Ile Asp Pro Asn Asn Ala Ala Val Leu Gln Ser Ser Gly Lys Asn 
                565                 570                 575     


Leu Phe Tyr Leu Pro His Gly Leu Ser Ile Asp Lys Asp Gly Asn Tyr 
            580                 585                 590         


Trp Val Thr Asp Val Ala Leu His Gln Val Phe Lys Leu Asp Pro Asn 
        595                 600                 605             


Asn Lys Glu Gly Pro Val Leu Ile Leu Gly Arg Ser Met Gln Pro Gly 
    610                 615                 620                 


Ser Asp Gln Asn His Phe Cys Gln Pro Thr Asp Val Ala Val Asp Pro 
625                 630                 635                 640 


Gly Thr Gly Ala Ile Tyr Val Ser Asp Gly Tyr Cys Asn Ser Arg Ile 
                645                 650                 655     


Val Gln Phe Ser Pro Ser Gly Lys Phe Ile Thr Gln Trp Gly Glu Glu 
            660                 665                 670         


Ser Ser Gly Ser Ser Pro Leu Pro Gly Gln Phe Thr Val Pro His Ser 
        675                 680                 685             


Leu Ala Leu Val Pro Leu Leu Gly Gln Leu Cys Val Ala Asp Arg Glu 
    690                 695                 700                 


Asn Gly Arg Ile Gln Cys Phe Lys Thr Asp Thr Lys Glu Phe Val Arg 
705                 710                 715                 720 


Glu Ile Lys His Ser Ser Phe Gly Arg Asn Val Phe Ala Ile Ser Tyr 
                725                 730                 735     


Ile Pro Gly Leu Leu Phe Ala Val Asn Gly Lys Pro His Phe Gly Asp 
            740                 745                 750         


Gln Glu Pro Val Gln Gly Phe Val Met Asn Phe Ser Asn Gly Glu Ile 
        755                 760                 765             


Ile Asp Ile Phe Lys Pro Val Arg Lys His Phe Asp Met Pro His Asp 
    770                 775                 780                 


Ile Val Ala Ser Glu Asp Gly Thr Val Tyr Ile Gly Asp Ala His Thr 
785                 790                 795                 800 


Asn Thr Val Trp Lys Phe Thr Leu Thr Glu Lys Leu Glu His Arg Ser 
                805                 810                 815     


Val Lys Lys Ala Gly Ile Glu Val Gln Glu Ile Lys Glu Ala Glu Ala 
            820                 825                 830         


Val Val Glu Thr Lys Met Glu Asn Lys Pro Thr Ser Ser Glu Leu Gln 
        835                 840                 845             


Lys Met Gln Glu Lys Gln Lys Leu Ile Lys Glu Pro Gly Ser Gly Val 
    850                 855                 860                 


Pro Val Val Leu Ile Thr Thr Leu Leu Val Ile Pro Val Val Val Leu 
865                 870                 875                 880 


Leu Ala Ile Ala Ile Phe Ile Arg Trp Lys Lys Ser Arg Ala Phe Gly 
                885                 890                 895     


Ala Asp Ser Glu His Lys Leu Glu Thr Ser Ser Gly Arg Val Leu Gly 
            900                 905                 910         


Arg Phe Arg Gly Lys Gly Ser Gly Gly Leu Asn Leu Gly Asn Phe Phe 
        915                 920                 925             


Ala Ser Arg Lys Gly Tyr Ser Arg Lys Gly Phe Asp Arg Leu Ser Thr 
    930                 935                 940                 


Glu Gly Ser Asp Gln Glu Lys Glu Asp Asp Gly Ser Glu Ser Glu Glu 
945                 950                 955                 960 


Glu Tyr Ser Ala Pro Leu Pro Ala Leu Ala Pro Ser Ser Ser 
                965                 970                 


<210>  25
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  25
gaagcaccgg tgagtgggca ggggctccct ccccatcaat agggccgacc caagtcttcc       60

tcccccttcc cccatgccgg gccccacgat agtgtgaatg tcaggggctt caggtttccc      120

taaatatagg tccctgccag aggatccgtg gcgggaaaag ggcaggggtc attagagaag      180

atcggggaca catgtggggc gggcaggagc tgccttataa ccagcccggg aacccctagc      240

tcactcgctg ctgaccaggc tctgccggct ccttcggcct cgccgcagga acttgctact      300

accagcacca tgccctacca atatccagca ctgaccccgg agcagaagaa ggagctgtct      360

gacatcgctc accgcatcgt ggcacctggc aagggcatcc tggctgcaga tgagtccact      420

gggagcattg ccaagcggct gcagtccatt ggcaccgaga acaccgagga gaaccggcgc      480

ttctaccgcc agctgctgct gacagctgac gaccgcgtga acccctgcat tgggggtgtc      540

atcctcttcc atgagacact ctaccagaag gcggatgatg ggcgtccctt cccccaagtt      600

atcaaatcca agggcggtgt tgtgggcatc aaggtagaca agggcgtggt ccccctggca      660

gggacaaatg gcgagactac cacccaaggg ttggatgggc tgtctgagcg ctgtgcccag      720

tacaagaagg acggagctga cttcgccaag tggcgttgtg tgctgaagat tggggaacac      780

accccctcag ccctcgccat catggaaaat gccaatgttc tggcccgtta tgccagtatc      840

tgccagcaga atggcattgt gcccatcgtg gagcctgaga tcctccctga tggggaccat      900

gacttgaagc gctgccagta tgtgaccgag aaggtgctgg ctgctgtcta caaggctctg      960

agtgaccacc acatctacct ggaaggcacc ttgctgaagc ccaacatggt caccccaggc     1020

catgcttgca ctcagaagtt ttctcatgag gagattgcca tggcgaccgt cacagcgctg     1080

cgccgcacag tgccccccgc tgtcactggg atcaccttcc tgtctggagg ccagagtgag     1140

gaggaggcgt ccatcaacct caatgccatt aacaagtgcc ccctgctgaa gccctgggcc     1200

ctgaccttct cctacggccg agccctgcag gcctctgccc tgaaggcctg gggcgggaag     1260

aaggagaacc tgaaggctgc gcaggaggag tatgtcaagc gagccctggc caacagcctt     1320

gcctgtcaag gaaagtacac tccgagcggt caggctgggg ctgctgccag cgagtccctc     1380

ttcgtctcta accacgccta ttaagcggag gtgttcccag gctgccccca acactccagg     1440

ccctgccccc tcccactctt gaagaggagg ccgcctcctc ggggctccag gctggcttgc     1500

ccgcgctctt tcttccctcg tgacagtggt gtgtggtgtc gtctgtgaat gctaagtcca     1560

tcaccctttc cggcacactg ccaaataaac agctatttaa gggggagtcg gcaaaaaaaa     1620

aaaaaaaaaa                                                            1630


<210>  26
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  27
<211>  4592
<212>  DNA
<213>  Homo sapiens

<400>  27
agaatgcact gctgacacgt gtgcgcgcgc gcggctccac tgccgggcga ccgcgggaaa       60

attccaaaaa aactcaaaaa gccaatacga ggcaaagcca aattttcaag ccacagatcc      120

cgggcggtgg cttcctttcc gccactgccc aaactgctga agcagctccc gcgaggacca      180

cccgatttaa tgtgtgccga ccatttcctt cagtgctgga caggctgctg tgaagggaca      240

tcaccttttc gctttttcca agatggctca agattcagta gatctttctt gtgattatca      300

gttttggatg cagaagcttt ctgtatggga tcaggcttcc actttggaaa cccagcaaga      360

cacctgtctt cacgtggctc agttccagga gttcctaagg aagatgtatg aagccttgaa      420

agagatggat tctaatacag tcattgaaag attccccaca attggtcaac tgttggcaaa      480

agcttgttgg aatcctttta ttttagcata tgatgaaagc caaaaaattc taatatggtg      540

cttatgttgt ctaattaaca aagaaccaca gaattctgga caatcaaaac ttaactcctg      600

gatacagggt gtattatctc atatactttc agcactcaga tttgataaag aagttgctct      660

tttcactcaa ggtcttgggt atgcacctat agattactat cctggtttgc ttaaaaatat      720

ggttttatca ttagcgtctg aactcagaga gaatcatctt aatggattta acactcaaag      780

gcgaatggct cccgagcgag tggcgtccct gtcacgagtt tgtgtcccac ttattaccct      840

gacagatgtt gaccccctgg tggaggctct cctcatctgt catggacgtg aacctcagga      900

aatcctccag ccagagttct ttgaggctgt aaacgaggcc attttgctga agaagatttc      960

tctccccatg tcagctgtag tctgcctctg gcttcggcac cttcccagcc ttgaaaaagc     1020

aatgctgcat ctttttgaaa agctaatctc cagtgagaga aattgtctga gaaggatcga     1080

atgctttata aaagattcat cgctgcctca agcagcctgc caccctgcca tattccgggt     1140

tgttgatgag atgttcaggt gtgcactcct ggaaaccgat ggggccctgg aaatcatagc     1200

cactattcag gtgtttacgc agtgctttgt agaagctctg gagaaagcaa gcaagcagct     1260

gcggtttgca ctcaagacct actttcctta cacttctcca tctcttgcca tggtgctgct     1320

gcaagaccct caagatatcc ctcggggaca ctggctccag acactgaagc atatttctga     1380

actgctcaga gaagcagttg aagaccagac tcatgggtcc tgcggaggtc cctttgagag     1440

ctggttcctg ttcattcact tcggaggatg ggctgagatg gtggcagagc aattactgat     1500

gtcggcagcc gaacccccca cggccctgct gtggctcttg gccttctact acggcccccg     1560

tgatgggagg cagcagagag cacagactat ggtccaggtg aaggccgtgc tgggccacct     1620

cctggcaatg tccagaagca gcagcctctc agcccaggac ctgcagacgg tagcaggaca     1680

gggcacagac acagacctca gagctcctgc acaacagctg atcaggcacc ttctcctcaa     1740

cttcctgctc tgggctcctg gaggccacac gatcgcctgg gatgtcatca ccctgatggc     1800

tcacactgct gagataactc acgagatcat tggctttctt gaccagacct tgtacagatg     1860

gaatcgtctt ggcattgaaa gccctagatc agaaaaactg gcccgagagc tccttaaaga     1920

gctgcgaact caagtctaga aggcacgcag gccgtgtggg tgcccggcgt gagggatcag     1980

gctcgccagg gccacaggac aggtgatgac ctgtggccac gcatttgtgg agtaagtgcc     2040

ctcgctgggc tgtgagaatg agctgtacac atcttgggac aatctgctag tatctatttt     2100

acaaaatgca gagccaggtc cctcagccca gactcagtca gacatgttca ctaatgactc     2160

aagtgagcct tcggtactcc tggtgcccgc ccggccagac cgtcagcttg ataattacta     2220

aagcaaaggc ctgggtggga gaacaggttt ctagttttta cccaagtcaa gctgcacatc     2280

tattatttaa aaattcaaag tcttagaacc aagaatttgg tcatgaacca ttaaagaatt     2340

tagagagaac ttagctcttt ttagactctt tttaggagtc agggatctgg gataaagcca     2400

cactgtcttg ctgtatggag aaattcttca aggggagtca gggtccctca ggcttccctt     2460

gtgtctccct ggacctgcct gacaggccac aggagcagac agcacaccca agcccgggcc     2520

tccggcacac tctttccact ctgtatttgc taaatgatgc taactgctac caaaaggccc     2580

ttgggacatc agaggagccg gcaggcgaag gtagaggatg tgttccagaa acattagaag     2640

gcaggattaa ttcagttagt tagttctctt gttaaatgga aatgggaatt ggaaattcct     2700

gataaagaat tggcctggct gggtgcagtg gctcacacct gtgatcccag cactttggga     2760

ggccaaggca gggggattac ttcagcccag gagttccaga ctgcctggct aacatggcaa     2820

taccctatct ctactaaaaa tacaaaaatt atcggggtgc aatggcatgc atctgtaatc     2880

ccagctattc aagaggctga ggcatgagga tctcttgaac ccgggaggtg ggagttgtag     2940

tgagccgaga tcatgacact gcactccagc ctgggcaaca gagcgagacc atctcttaaa     3000

aaaaggcatt gttagtgtaa tctcaaggtt aacatttatt tcatgtcagt acagggtgct     3060

ttttcctttc agggacattc tggaattgta ttggttgtac attcttttgt gtctattctg     3120

tttgtcaagt gagtcaagac ttgcttttgt ccattttgat ttgtgtgtat tagtctgagt     3180

cttggctccg ttttgaggta tgagcaaagt tttgctggat tagaagttaa cctttaggga     3240

aattccttat tttggtatgt ggcaatgcta atagatccac tgaagatctg gaaaattcca     3300

ggaacttttc acctgagcct ttcttctgag aaatgctgca gtcagaaggg tgtgctggta     3360

aagtattttg gtggcagctg ccatcatggt cattgccttc atataacatg cttcgtgctc     3420

atggtcattg ccttcatata acatgcttcg tgccatcatg atccttgcct tcatataaca     3480

aacatgcttc gtcagaggtg ttggggttga aaaaggagct gcatgcttca ctggagttga     3540

gggcctctct cctgttctga ctttaagcca gaacttgtgg ctgggccatg gaagctgtga     3600

ctcctctgtg gacatggtgg cagcagggaa cccctagaga gaggggccac tgggaccagg     3660

cctcctgttg tggagggact cctgggacag tcctccaccc tgtcctgtgg tcctgtgtac     3720

agggttggcc tcttcctcct cccctgccag gcctctgccc atgccccttc cttccttctc     3780

ctgggactgg tgaagctagg catctggaag acttcttcct agcctggaag ccctgacctc     3840

ggcccatctg cagaatctcc cagttccttc acagctgccg agtcctctca cgggtgcggt     3900

ggaggcggcc ttgccggtgg tgctttctgg gcagccaggg gttcctgggt gggaggactg     3960

tccctctggg gacgtggcac tgaagtgcct gctggcttca tgtggccctt tgccctttcc     4020

cagcctgaga gatgctcaaa ggtggggagc tgggggagcc acccctcggc cattccctcc     4080

acctccaaga caggtggcgg ccgggcaggc actcttaagc ccacctcccc ctcttgttgc     4140

cttcgatttc ggcaaagcct gggcaggtgc caccgggaag gaatggcatc cgagatgctg     4200

ggcggggacg cggcgtggcc gagggggcct tgacggcgtt ggcggggcct gggcacaggg     4260

gcagccgcag ggaggcaggg atggcaaggc gtgaagccac cctggaagga actggaccaa     4320

ggtcttcaga ggtgcgacag ggtctggaat ctgaccttac tctagcagga gtttttgtag     4380

actctccctg atagtttagt ttttgataaa gcatgctggt aaaaccacta ccctcagaga     4440

gagccaaaaa tacagaagag gcggagagcg cccctccaac caggctgtta ttcccctgga     4500

ctccgtgaca tctgtggaat tttttagctc tttaaaatct gtaatttgtt gtctattttt     4560

tcattctaaa taaaacttca gtttgcacct aa                                   4592


<210>  28
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Gln Asp Ser Val Asp Leu Ser Cys Asp Tyr Gln Phe Trp Met 
1               5                   10                  15      


Gln Lys Leu Ser Val Trp Asp Gln Ala Ser Thr Leu Glu Thr Gln Gln 
            20                  25                  30          


Asp Thr Cys Leu His Val Ala Gln Phe Gln Glu Phe Leu Arg Lys Met 
        35                  40                  45              


Tyr Glu Ala Leu Lys Glu Met Asp Ser Asn Thr Val Ile Glu Arg Phe 
    50                  55                  60                  


Pro Thr Ile Gly Gln Leu Leu Ala Lys Ala Cys Trp Asn Pro Phe Ile 
65                  70                  75                  80  


Leu Ala Tyr Asp Glu Ser Gln Lys Ile Leu Ile Trp Cys Leu Cys Cys 
                85                  90                  95      


Leu Ile Asn Lys Glu Pro Gln Asn Ser Gly Gln Ser Lys Leu Asn Ser 
            100                 105                 110         


Trp Ile Gln Gly Val Leu Ser His Ile Leu Ser Ala Leu Arg Phe Asp 
        115                 120                 125             


Lys Glu Val Ala Leu Phe Thr Gln Gly Leu Gly Tyr Ala Pro Ile Asp 
    130                 135                 140                 


Tyr Tyr Pro Gly Leu Leu Lys Asn Met Val Leu Ser Leu Ala Ser Glu 
145                 150                 155                 160 


Leu Arg Glu Asn His Leu Asn Gly Phe Asn Thr Gln Arg Arg Met Ala 
                165                 170                 175     


Pro Glu Arg Val Ala Ser Leu Ser Arg Val Cys Val Pro Leu Ile Thr 
            180                 185                 190         


Leu Thr Asp Val Asp Pro Leu Val Glu Ala Leu Leu Ile Cys His Gly 
        195                 200                 205             


Arg Glu Pro Gln Glu Ile Leu Gln Pro Glu Phe Phe Glu Ala Val Asn 
    210                 215                 220                 


Glu Ala Ile Leu Leu Lys Lys Ile Ser Leu Pro Met Ser Ala Val Val 
225                 230                 235                 240 


Cys Leu Trp Leu Arg His Leu Pro Ser Leu Glu Lys Ala Met Leu His 
                245                 250                 255     


Leu Phe Glu Lys Leu Ile Ser Ser Glu Arg Asn Cys Leu Arg Arg Ile 
            260                 265                 270         


Glu Cys Phe Ile Lys Asp Ser Ser Leu Pro Gln Ala Ala Cys His Pro 
        275                 280                 285             


Ala Ile Phe Arg Val Val Asp Glu Met Phe Arg Cys Ala Leu Leu Glu 
    290                 295                 300                 


Thr Asp Gly Ala Leu Glu Ile Ile Ala Thr Ile Gln Val Phe Thr Gln 
305                 310                 315                 320 


Cys Phe Val Glu Ala Leu Glu Lys Ala Ser Lys Gln Leu Arg Phe Ala 
                325                 330                 335     


Leu Lys Thr Tyr Phe Pro Tyr Thr Ser Pro Ser Leu Ala Met Val Leu 
            340                 345                 350         


Leu Gln Asp Pro Gln Asp Ile Pro Arg Gly His Trp Leu Gln Thr Leu 
        355                 360                 365             


Lys His Ile Ser Glu Leu Leu Arg Glu Ala Val Glu Asp Gln Thr His 
    370                 375                 380                 


Gly Ser Cys Gly Gly Pro Phe Glu Ser Trp Phe Leu Phe Ile His Phe 
385                 390                 395                 400 


Gly Gly Trp Ala Glu Met Val Ala Glu Gln Leu Leu Met Ser Ala Ala 
                405                 410                 415     


Glu Pro Pro Thr Ala Leu Leu Trp Leu Leu Ala Phe Tyr Tyr Gly Pro 
            420                 425                 430         


Arg Asp Gly Arg Gln Gln Arg Ala Gln Thr Met Val Gln Val Lys Ala 
        435                 440                 445             


Val Leu Gly His Leu Leu Ala Met Ser Arg Ser Ser Ser Leu Ser Ala 
    450                 455                 460                 


Gln Asp Leu Gln Thr Val Ala Gly Gln Gly Thr Asp Thr Asp Leu Arg 
465                 470                 475                 480 


Ala Pro Ala Gln Gln Leu Ile Arg His Leu Leu Leu Asn Phe Leu Leu 
                485                 490                 495     


Trp Ala Pro Gly Gly His Thr Ile Ala Trp Asp Val Ile Thr Leu Met 
            500                 505                 510         


Ala His Thr Ala Glu Ile Thr His Glu Ile Ile Gly Phe Leu Asp Gln 
        515                 520                 525             


Thr Leu Tyr Arg Trp Asn Arg Leu Gly Ile Glu Ser Pro Arg Ser Glu 
    530                 535                 540                 


Lys Leu Ala Arg Glu Leu Leu Lys Glu Leu Arg Thr Gln Val 
545                 550                 555             


<210>  29
<211>  3072
<212>  DNA
<213>  Homo sapiens

<400>  29
aacggctcgc ggagcggcta cgcggagtga catcgccggt gtttgcgggt ggttgttgct       60

ctcggggccg tgtggagtag gtctggacct ggactcacgg ctgcttggag cgtccgccat      120

gaggagaagt gaggtgctgg cggaggagtc catagtatgt ctgcagaaag ccctaaatca      180

ccttcgggaa atatgggagc taattgggat tccagaggac cagcggttac aaagaactga      240

ggtggtaaag aagcatatca aggaactcct ggatatgatg attgctgaag aggaaagcct      300

gaaggaaaga ctcatcaaaa gcatatccgt ctgtcagaaa gagctgaaca ctctgtgcag      360

cgagttacat gttgagccat ttcaggaaga aggagagacg accatcttgc aactagaaaa      420

agatttgcgc acccaagtgg aattgatgcg aaaacagaaa aaggagagaa aacaggaact      480

gaagctactt caagagcaag atcaagaact gtgcgaaatt ctttgtatgc cccactatga      540

tattgacagt gcctcagtgc ccagcttaga agagctgaac cagttcaggc aacatgtgac      600

aactttgagg gaaacaaagg cttctaggcg tgaggagttt gtcagtataa agagacagat      660

catactgtgt atggaagcat tagaccacac cccagacaca agctttgaaa gagatgtggt      720

gtgtgaagac gaagatgcct tttgtttgtc tttggagaat attgcaacac tacaaaagtt      780

gctacggcag ctggaaatgc agaaatcaca aaatgaagca gtgtgtgagg ggctgcgtac      840

tcaaatccga gagctctggg acaggttgca aatacctgaa gaagaaagag aagctgtggc      900

caccattatg tctgggtcaa aggccaaggt ccggaaagcg ctgcaattag aagtggatcg      960

gttggaagaa ctgaaaatgc aaaacatgaa gaaagtgatt gaggcaattc gagtggagct     1020

ggttcagtac tgggaccagt gcttttatag ccaggagcag agacaagctt ttgccccttt     1080

ctgtgctgag gactacacag aaagtctgct ccagctccac gatgctgaga ttgtgcggtt     1140

aaaaaactac tatgaagttc acaaggaact ctttgaaggt gtccagaagt gggaagaaac     1200

ctggaggctt ttcttagagt ttgagagaaa agcttcagat ccaaatcgat ttacaaaccg     1260

aggaggaaat cttctaaaag aagaaaaaca acgagccaag ctccagaaaa tgctgcccaa     1320

gctggaagaa gagttgaagg cacgaattga attgtgggaa caggaacatt caaaggcatt     1380

tatggtgaat gggcagaaat tcatggagta tgtggcagaa caatgggaga tgcatcgatt     1440

ggagaaagag agagccaagc aggaaagaca actgaagaac aaaaaacaga cagagacaga     1500

gatgctgtat ggcagcgctc ctcgaacacc tagcaagcgg cgaggactgg ctcccaatac     1560

accgggcaaa gcacgtaagc tgaacactac caccatgtcc aatgctacgg ccaatagtag     1620

cattcggcct atctttggag ggacagtcta ccactccccc gtgtctcgac ttcctccttc     1680

tggcagcaag ccagtcgctg cttccacctg ttcagggaag aaaacacccc gtactggcag     1740

gcatggagcc aacaaggaga acctggagct caacggcagc atcctgagtg gtgggtaccc     1800

tggctcggcc cccctccagc gcaacttcag cattaattct gttgccagca cctattctga     1860

gtttgcgaag gatccgtccc tctctgacag ttccactgtt gggcttcagc gagaactttc     1920

aaaggcttcc aaatctgatg ctacttctgg aatcctcaat tcaaccaaca tccagtcctg     1980

agaagccctg atcagtcaac cagctgtggc ttcctgtgcc tagactggac ctaattatat     2040

gggggtgact ttagtttttc ttcagcttag gcgtgcttga aaccttggcc aggttccatg     2100

accatgggcc taacttaaag atgtgaatga gtgttacagt tgaaagccca tcataggttt     2160

agtggtccta ggagacttgg ttttgactta tatacatgaa aagtttatgg caagaagtgc     2220

aaattttagc atatggggcc tgacttctct accacataat tctacttgct gaagcatgat     2280

caaagcttgt tttatttcac cactgtagga aaatgattga ctatgcccat ccctgggggt     2340

aattttggca tgtatacctg taactagtaa ttaacatctt ttttgtttag gcatgttcaa     2400

ttaatgctgt agctatcata gctttgctct tacctgaagc cttgtcccca ccacacagga     2460

cagccttcct cctgaagaga atgtctttgt gtgtccgaag ttgagatggc ctgccctact     2520

gccaaagagg tgacaggaag gctgggagca gctttgttaa attgtgttca gttctgttac     2580

acagtgcatt gccctttgtt gggggtatgc atgtatgaac acacatgctt gtcggaacgc     2640

tttctcggcg tttgtccctt ggctctcatc tcccccattc ctgtgcctac tttgcctgag     2700

ttcttctacc cccgcagttg ccagccacat tgggagtctg tttgttccaa tgggttgagc     2760

tgtctttgtc gtggagatct ggaactttgc acatgtcact actggggagg tgttcctgct     2820

ctagcttcca cgatgaggcg ccctctttac ctatcctctc aatcactact cttcttgaag     2880

cactattatt tattcttccg ctgtctgcct gcagcagtac tactgtcaac atagtgtaaa     2940

tggttctcaa aagcttacca gtgtggactt ggtgttagcc acgctgttta ctcatacagt     3000

acgtgtcctg tttttaaaat atacaattat tcttaaaaat aaattaaaat ctgtatactt     3060

acatttcaaa aa                                                         3072


<210>  30
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Arg Ser Glu Val Leu Ala Glu Glu Ser Ile Val Cys Leu Gln 
1               5                   10                  15      


Lys Ala Leu Asn His Leu Arg Glu Ile Trp Glu Leu Ile Gly Ile Pro 
            20                  25                  30          


Glu Asp Gln Arg Leu Gln Arg Thr Glu Val Val Lys Lys His Ile Lys 
        35                  40                  45              


Glu Leu Leu Asp Met Met Ile Ala Glu Glu Glu Ser Leu Lys Glu Arg 
    50                  55                  60                  


Leu Ile Lys Ser Ile Ser Val Cys Gln Lys Glu Leu Asn Thr Leu Cys 
65                  70                  75                  80  


Ser Glu Leu His Val Glu Pro Phe Gln Glu Glu Gly Glu Thr Thr Ile 
                85                  90                  95      


Leu Gln Leu Glu Lys Asp Leu Arg Thr Gln Val Glu Leu Met Arg Lys 
            100                 105                 110         


Gln Lys Lys Glu Arg Lys Gln Glu Leu Lys Leu Leu Gln Glu Gln Asp 
        115                 120                 125             


Gln Glu Leu Cys Glu Ile Leu Cys Met Pro His Tyr Asp Ile Asp Ser 
    130                 135                 140                 


Ala Ser Val Pro Ser Leu Glu Glu Leu Asn Gln Phe Arg Gln His Val 
145                 150                 155                 160 


Thr Thr Leu Arg Glu Thr Lys Ala Ser Arg Arg Glu Glu Phe Val Ser 
                165                 170                 175     


Ile Lys Arg Gln Ile Ile Leu Cys Met Glu Ala Leu Asp His Thr Pro 
            180                 185                 190         


Asp Thr Ser Phe Glu Arg Asp Val Val Cys Glu Asp Glu Asp Ala Phe 
        195                 200                 205             


Cys Leu Ser Leu Glu Asn Ile Ala Thr Leu Gln Lys Leu Leu Arg Gln 
    210                 215                 220                 


Leu Glu Met Gln Lys Ser Gln Asn Glu Ala Val Cys Glu Gly Leu Arg 
225                 230                 235                 240 


Thr Gln Ile Arg Glu Leu Trp Asp Arg Leu Gln Ile Pro Glu Glu Glu 
                245                 250                 255     


Arg Glu Ala Val Ala Thr Ile Met Ser Gly Ser Lys Ala Lys Val Arg 
            260                 265                 270         


Lys Ala Leu Gln Leu Glu Val Asp Arg Leu Glu Glu Leu Lys Met Gln 
        275                 280                 285             


Asn Met Lys Lys Val Ile Glu Ala Ile Arg Val Glu Leu Val Gln Tyr 
    290                 295                 300                 


Trp Asp Gln Cys Phe Tyr Ser Gln Glu Gln Arg Gln Ala Phe Ala Pro 
305                 310                 315                 320 


Phe Cys Ala Glu Asp Tyr Thr Glu Ser Leu Leu Gln Leu His Asp Ala 
                325                 330                 335     


Glu Ile Val Arg Leu Lys Asn Tyr Tyr Glu Val His Lys Glu Leu Phe 
            340                 345                 350         


Glu Gly Val Gln Lys Trp Glu Glu Thr Trp Arg Leu Phe Leu Glu Phe 
        355                 360                 365             


Glu Arg Lys Ala Ser Asp Pro Asn Arg Phe Thr Asn Arg Gly Gly Asn 
    370                 375                 380                 


Leu Leu Lys Glu Glu Lys Gln Arg Ala Lys Leu Gln Lys Met Leu Pro 
385                 390                 395                 400 


Lys Leu Glu Glu Glu Leu Lys Ala Arg Ile Glu Leu Trp Glu Gln Glu 
                405                 410                 415     


His Ser Lys Ala Phe Met Val Asn Gly Gln Lys Phe Met Glu Tyr Val 
            420                 425                 430         


Ala Glu Gln Trp Glu Met His Arg Leu Glu Lys Glu Arg Ala Lys Gln 
        435                 440                 445             


Glu Arg Gln Leu Lys Asn Lys Lys Gln Thr Glu Thr Glu Met Leu Tyr 
    450                 455                 460                 


Gly Ser Ala Pro Arg Thr Pro Ser Lys Arg Arg Gly Leu Ala Pro Asn 
465                 470                 475                 480 


Thr Pro Gly Lys Ala Arg Lys Leu Asn Thr Thr Thr Met Ser Asn Ala 
                485                 490                 495     


Thr Ala Asn Ser Ser Ile Arg Pro Ile Phe Gly Gly Thr Val Tyr His 
            500                 505                 510         


Ser Pro Val Ser Arg Leu Pro Pro Ser Gly Ser Lys Pro Val Ala Ala 
        515                 520                 525             


Ser Thr Cys Ser Gly Lys Lys Thr Pro Arg Thr Gly Arg His Gly Ala 
    530                 535                 540                 


Asn Lys Glu Asn Leu Glu Leu Asn Gly Ser Ile Leu Ser Gly Gly Tyr 
545                 550                 555                 560 


Pro Gly Ser Ala Pro Leu Gln Arg Asn Phe Ser Ile Asn Ser Val Ala 
                565                 570                 575     


Ser Thr Tyr Ser Glu Phe Ala Lys Asp Pro Ser Leu Ser Asp Ser Ser 
            580                 585                 590         


Thr Val Gly Leu Gln Arg Glu Leu Ser Lys Ala Ser Lys Ser Asp Ala 
        595                 600                 605             


Thr Ser Gly Ile Leu Asn Ser Thr Asn Ile Gln Ser 
    610                 615                 620 


<210>  31
<211>  4519
<212>  DNA
<213>  Homo sapiens

<400>  31
gcactccacc acctctggcc gctgggaaga cgtcatcgct tccgccctac ttcctcctcc       60

tgttggcggc ggtgagaatc caatatggag taaatcggtg gagtcgagag atggggctcg      120

gacggggcgc cctgcaccgc ctcccaggcg cacctccccc ggccgccgac cgctccccgg      180

aaccgtgatt ggcccggccc cccgggggcg accccggact gagccccccc acccgcggcc      240

ggcgctctcc tcctcctcgc agcagtccct gccgctccga ggcgcgcttg tttttctcct      300

gctctccccc accgccgtcc ccttcccaaa tctcgccccc tctgcccgct cccgagcccc      360

cggagcctcc gcccgcctct ccccacggcg ctgcggcgtt cactccccgc gcagcctgcc      420

tttgcacccc ttcccccaaa ccctatcccg cgccctgctt ccccttctgc tgcggcgccc      480

tcttcatctc tagccgcccc ccctccccaa atcaggcgat ctccggagat gtgaagaagg      540

ggggcgagcg gacaggaaga tgaagggagc aaagctgccc gccgcgggac aggcgtctag      600

gtgaacaaga aaatgaccga agaaacacac ccagacgatg acagctatat tgtgcgtgtc      660

aaggctgtgg ttatgaccag agatgactcc agcgggggat ggttcccaca ggaaggaggc      720

gggatcagtc gcgtcggggt ctgtaaggtc atgcaccccg aaggcaatgg acgaagcggc      780

tttctcatcc atggtgaacg acagaaagac aaactggtgg tattggaatg ctatgtaaga      840

aaggacttgg tctacaccaa agccaatcca acgtttcatc actggaaggt cgataatagg      900

aagtttggac ttactttcca aagccctgct gatgcccgag cctttgacag gggagtaagg      960

aaagcaatcg aagaccttat agaaggttca acaacgtcat cttccaccat ccataatgaa     1020

gctgagcttg gcgatgatga cgtttttaca acagctacag acagttcttc taattcctct     1080

cagaagagag agcaacctac tcggacaatc tcctctccca catcctgtga gcaccggagg     1140

atttataccc tgggccacct ccacgactca taccccacag accactatca cctcgatcag     1200

ccgatgccaa ggccctaccg ccaggtgagc ttcccggacg acgacgagga gatcgtgcgc     1260

atcaaccccc gggagaagat ctggatgacg gggtacgagg attaccggca cgcacccgtc     1320

aggggcaagt acccggaccc ctcggaggac gcggactcct cctacgtgcg cttcgccaag     1380

ggcgaggtcc ccaagcatga ctacaactac ccctacgtgg actcctcaga ctttggccta     1440

ggcgaggacc ccaaaggccg cgggggcagc gtgatcaaga cgcagccctc ccggggcaag     1500

tcgcggcggc ggaaggagga cggagagcgc tcgcggtgcg tgtactgcag ggacatgttc     1560

aaccacgagg agaaccgccg gggccactgc caggacgcgc ccgactccgt gagaacttgc     1620

atccgccggg tgagctgcat gtggtgcgcg gacagcatgc tctatcactg tatgtcggac     1680

cccgagggag actatacaga cccttgctcg tgcgatacta gcgacgagaa gttttgcctc     1740

cggtggatgg ctcttattgc cttgtctttc ctggccccct gtatgtgctg ttacctgccc     1800

cttcgggcct gctaccactg cggagtgatg tgcaggtgct gtggcgggaa gcacaaagcg     1860

gccgcgtgac tcagtttccc tcccttctcc ctccatccgc agccacaggg gaactcgtct     1920

cttacatact ctcatcttct cccccgctcc cttccactcc aaggagcgag gagggcaagc     1980

ggcctcccag ctccctggta cctcgaggca ccattccagc cagggacgct gccgggtaga     2040

ctctccactc cccctgccgc ccacactgca gcagccacat ccatacacac acgctcgcac     2100

agtgttctga ggaaggaacc ttcgccacag actcctgtac tattaacaat ctgtaaccaa     2160

gctaactgtc tcatccatgt gttgatttcc tgtttcctcc tcccccgcct cttccagttc     2220

aaaggagtct gcaattggaa ctgctgattt tcggtgggtt ttgtagttga tttttccaag     2280

agcgtcgaag actctctttc tcttggttca ccttgcctgt cgctagcaag catctggttc     2340

agcggaaatg ggatgtgaga atgatgaaac ccgacagaag tatctcagcc tgcagtcagt     2400

tattatgtat aggaggtgag ctagttaaca aacttgtacc acaaaacaat atcgctttaa     2460

cttttctaaa gccaaatttc ccatgtaagc tgcagtttct atctttagcc catcatcatt     2520

ttctgccccc ccaaaatctg ttgaaatgat tcactgatgc aaaacattca cccgtaatag     2580

actgagaatt gagccttaac ttcagattaa cttgtgagaa tcaggaaaat tccttcaact     2640

gcattgcatc ctcttggacc agggctagaa tggggatttc aggtttctat gagcctcccc     2700

attaccccta aagtagaaca ttttttaaat tgtgttgcca ccacttctaa aaatttagca     2760

atattagaat aggatactag tgaagtaaga aattttgctt gttgttttgc aaaccaaata     2820

gtttcctcaa acacaaatca gtgttcccac gaacaagttc cagttgagaa acactaaggt     2880

tatggtgaat aaaaccatag ggagcttctt ccccccaacc cctggctatt ttatattaat     2940

ggggagaggg gatttttaaa tgtcataaat ttgaagagtg gtgggttgca ttttcttcat     3000

gggtttatgt tttcgtttca ttttggactc aatttcacat caccaaattc ctcatttata     3060

cttggggaaa aaacaaggcc atatgtaaaa acccttccaa tgcctaagtg tctttctcct     3120

gcaactccaa acccagactc gccactttgg gtgcacaggt ggttaggtca gccaactggt     3180

tctgcctgtc gccttgccac ggaggaggct tctaattagc tggaaaagag tatttttcta     3240

atacgttgca aggattagcc aaatcttctt attgaagaaa gaagaaaagt gaagagtggt     3300

tacctatacc tagcatagta caatcagaac ctcgtggaga ccaccgggga caggcttgcg     3360

gacgccggct gttcttcccg ccacgatctt tctgtggtag cggccagcag aagacatggc     3420

ctgctcccca ctccctttcc ccactccttc tttattgcac acaggacacc agtcttcaag     3480

gaaagggact tttttccagt ctgccaatca tattgggaaa gtgctagctg tgctcacctt     3540

catggggctg tttccagctc gtccacaagc tcatcgattt tctttagtag attaccggtg     3600

taaataccca gtgtgcttat gagtcagtta gtagacgtct tcattcattg gagtaactgg     3660

tttaggcttt ccagtttgga aaaggagcag agagctgtcc atctggattg atggaagaaa     3720

agagaacctc atccatgcct ggagaacatc tagaaaacct tcagccagcc tccagtgctg     3780

tcgagagacc accttccccc gacccggagg cacttccttg gggtctttct ctagggtctc     3840

ttctctacaa agcacaacac taatgttcgt ttccttagac ctcagttcaa gtgcccctat     3900

ttatttcaat aagaacgcac atatcccagc tgttttttgt ttgtcacctc tatttagttg     3960

ttacctgttt ctctcttctt tcaccccttg tccttttcca cccttttaag agttacgcta     4020

gcagatctta ctccacgtat actttttggt ttgtgaaggc atcggttaag ggcacaaaga     4080

cagccatggg gacatttatg taaatacgtc tctaattgcc acactgcagc tgaacagtgt     4140

gtagtatttt cccagtcagc tttgccatac tgacgtcaat catttgagag aaattattca     4200

gattttattt ttgtatctgt ggtaacaaaa cattaaccaa aagattttct gtccagaagc     4260

ctccccgacc ccccaagcta tttgctcaca ttaacaaatt aaagtgcctg aagcataatt     4320

cattctttac ctgtatacta aaaaccctgt tgtattgatt tttttataat aagccttttt     4380

acctctgtgt aaaaaatata tatacaagtg tatgatgtac attttagttc ttaacttttt     4440

tttatggttt ctaatatgta tgaccaatgt agccattgct ttaaaatgta ccgtgtaaat     4500

ataaacacat cctatcaga                                                  4519


<210>  32
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Glu Glu Thr His Pro Asp Asp Asp Ser Tyr Ile Val Arg Val 
1               5                   10                  15      


Lys Ala Val Val Met Thr Arg Asp Asp Ser Ser Gly Gly Trp Phe Pro 
            20                  25                  30          


Gln Glu Gly Gly Gly Ile Ser Arg Val Gly Val Cys Lys Val Met His 
        35                  40                  45              


Pro Glu Gly Asn Gly Arg Ser Gly Phe Leu Ile His Gly Glu Arg Gln 
    50                  55                  60                  


Lys Asp Lys Leu Val Val Leu Glu Cys Tyr Val Arg Lys Asp Leu Val 
65                  70                  75                  80  


Tyr Thr Lys Ala Asn Pro Thr Phe His His Trp Lys Val Asp Asn Arg 
                85                  90                  95      


Lys Phe Gly Leu Thr Phe Gln Ser Pro Ala Asp Ala Arg Ala Phe Asp 
            100                 105                 110         


Arg Gly Val Arg Lys Ala Ile Glu Asp Leu Ile Glu Gly Ser Thr Thr 
        115                 120                 125             


Ser Ser Ser Thr Ile His Asn Glu Ala Glu Leu Gly Asp Asp Asp Val 
    130                 135                 140                 


Phe Thr Thr Ala Thr Asp Ser Ser Ser Asn Ser Ser Gln Lys Arg Glu 
145                 150                 155                 160 


Gln Pro Thr Arg Thr Ile Ser Ser Pro Thr Ser Cys Glu His Arg Arg 
                165                 170                 175     


Ile Tyr Thr Leu Gly His Leu His Asp Ser Tyr Pro Thr Asp His Tyr 
            180                 185                 190         


His Leu Asp Gln Pro Met Pro Arg Pro Tyr Arg Gln Val Ser Phe Pro 
        195                 200                 205             


Asp Asp Asp Glu Glu Ile Val Arg Ile Asn Pro Arg Glu Lys Ile Trp 
    210                 215                 220                 


Met Thr Gly Tyr Glu Asp Tyr Arg His Ala Pro Val Arg Gly Lys Tyr 
225                 230                 235                 240 


Pro Asp Pro Ser Glu Asp Ala Asp Ser Ser Tyr Val Arg Phe Ala Lys 
                245                 250                 255     


Gly Glu Val Pro Lys His Asp Tyr Asn Tyr Pro Tyr Val Asp Ser Ser 
            260                 265                 270         


Asp Phe Gly Leu Gly Glu Asp Pro Lys Gly Arg Gly Gly Ser Val Ile 
        275                 280                 285             


Lys Thr Gln Pro Ser Arg Gly Lys Ser Arg Arg Arg Lys Glu Asp Gly 
    290                 295                 300                 


Glu Arg Ser Arg Cys Val Tyr Cys Arg Asp Met Phe Asn His Glu Glu 
305                 310                 315                 320 


Asn Arg Arg Gly His Cys Gln Asp Ala Pro Asp Ser Val Arg Thr Cys 
                325                 330                 335     


Ile Arg Arg Val Ser Cys Met Trp Cys Ala Asp Ser Met Leu Tyr His 
            340                 345                 350         


Cys Met Ser Asp Pro Glu Gly Asp Tyr Thr Asp Pro Cys Ser Cys Asp 
        355                 360                 365             


Thr Ser Asp Glu Lys Phe Cys Leu Arg Trp Met Ala Leu Ile Ala Leu 
    370                 375                 380                 


Ser Phe Leu Ala Pro Cys Met Cys Cys Tyr Leu Pro Leu Arg Ala Cys 
385                 390                 395                 400 


Tyr His Cys Gly Val Met Cys Arg Cys Cys Gly Gly Lys His Lys Ala 
                405                 410                 415     


Ala Ala 
        


<210>  33
<211>  6682
<212>  DNA
<213>  Homo sapiens

<400>  33
atcagtctcc gcacgcggtt ccgcaggtgg cagcgatggc ccagtcctga actccccgcc       60

atggccggcg cccccggccc gctgcgcctt gcgctgctgc tgctcgggat ggtgggcagg      120

gccggccccc gcccccaggg tgccactgtg tccctctggg agacggtgca gaaatggcga      180

gaataccgac gccagtgcca gcgctccctg actgaggatc cacctcctgc cacagacttg      240

ttctgcaacc ggaccttcga tgaatacgcc tgctggccag atggggagcc aggctcgttc      300

gtgaatgtca gctgcccctg gtacctgccc tgggccagca gtgtgccgca gggccacgtg      360

taccggttct gcacagctga aggcctctgg ctgcagaagg acaactccag cctgccctgg      420

agggacttgt cggagtgcga ggagtccaag cgaggggaaa gaagctcccc ggaggagcag      480

ctcctgttcc tctacatcat ctacacggtg ggctacgcac tctccttctc tgctctggtt      540

atcgcctctg cgatcctcct cggcttcaga cacctgcact gcaccaggaa ctacatccac      600

ctgaacctgt ttgcatcctt catcctgcga gcattgtccg tcttcatcaa ggacgcagcc      660

ctgaagtgga tgtatagcac agccgcccag cagcaccagt gggatgggct cctctcctac      720

caggactctc tgagctgccg cctggtgttt ctgctcatgc agtactgtgt ggcggccaat      780

tactactggc tcttggtgga gggcgtgtac ctgtacacac tgctggcctt ctcggtctta      840

tctgagcaat ggatcttcag gctctacgtg agcataggct ggggtgttcc cctgctgttt      900

gttgtcccct ggggcattgt caagtacctc tatgaggacg agggctgctg gaccaggaac      960

tccaacatga actactggct cattatccgg ctgcccattc tctttgccat tggggtgaac     1020

ttcctcatct ttgttcgggt catctgcatc gtggtatcca aactgaaggc caatctcatg     1080

tgcaagacag acatcaaatg cagacttgcc aagtccacgc tgacactcat ccccctgctg     1140

gggactcatg aggtcatctt tgcctttgtg atggacgagc acgcccgggg gaccctgcgc     1200

ttcatcaagc tgtttacaga gctctccttc acctccttcc aggggctgat ggtggccata     1260

ttatactgct ttgtcaacaa tgaggtccag ctggaatttc ggaagagctg ggagcgctgg     1320

cggcttgagc acttgcacat ccagagggac agcagcatga agcccctcaa gtgtcccacc     1380

agcagcctga gcagtggagc cacggcgggc agcagcatgt acacagccac ttgccaggcc     1440

tcctgcagct gagactccag cgcctgccct ccctggggtc cttgctgcag gccgggtggc     1500

caatccaggt gggagagaca ctcccaggga caagggaagg aagggacaca cacacacaca     1560

cacacacaca cacacacaca cacatacatc ctgctttccc tccccaaacc catcagacag     1620

gtaaatgggc agtgcctcct gggaccatgg acacattttc tcctaggaga agcagcctcc     1680

taatttgatc acagtggcga gaggagagga aaaacgatcg ctgtgaaaat gaggaggatt     1740

gcttcttgtg aaaccacagg cccttggggt tcccccagac agagccgcaa atcaacccca     1800

gactcaaact caaggtcaac ggcttattag tgaaactggg gcttgcaaga ggaggtggtt     1860

ctgaaagtgg ctcttctaac ctcagccaaa cacagagcgg gagtgacggg agcctcctct     1920

gcttgcatca cttggggtca ccaccctccc ctgtcttctc tcaaagggaa gctgtttgtg     1980

tgtctgggtt gcttatttcc ctcatcttgc cccctcatct cactgcccag tttctttttg     2040

aggggctttg tttgggccac tgccagcagc tgtttctgga aatggctgta ggtggtgttg     2100

agaaagaatg agcattgaga cggtgctcgc ttctcctcca ggtatttgag ttgttttggt     2160

gcctgcctct gccatgccca gagaatcagg gcaggcttgc caccggggaa cccagccctg     2220

gggtatgagc tgccaagtct attttaaaga cgctcaagaa tcctctgggg ttcatctagg     2280

gacacgttag gaatgtccag actgtgggtg tagattacct gccacttcca ggagcccaga     2340

gggccaagag agacattgcc tccacctctc cttggaaata ctttatctgt gaccacacgc     2400

tgtctcttga gaatttggat acactctcta gctttagggg accatgaaga gactctctta     2460

gggaaaccaa tagtccccat cagcaccatg gaggcaggct ccccctgcct ttgaaattcc     2520

cccacttggg agcttgtata tacttcactc acttttcttt attgctgtga atagtctgtg     2580

tgcacaatgg gcaattctga cttctcccat ctagtggaaa tgagcgaaat catggttgta     2640

gtgatgttgt ttgggagagt gcagtagtaa ttgatttgac ccactcacac ttggagctaa     2700

ttaaggtttg ccctgcctgc agcctccccc acaaataatg aacagcagaa agactggacg     2760

gggaaaccta tcaatcctgc ccccagccat ggtgaggaag ccccaagcca tggtgacaca     2820

cagcagcact gcagatagcc agacacatgg ctatcctaga gaggctggca aggagttcgt     2880

ggctgcaaaa gaagtttctg gagcaagaga gagctcgctc ttgggagtca ggacctccgg     2940

ggagagcaga gggttccgac ggattccttt atgagtcagt ctctctctcc cttttaaatg     3000

gtgggaaccc tccccaaaac ctttccccag acacattctc ctgtgcccct cagagaggca     3060

tgtgatgtgc aaggaaaata ataggatata aaacacatca agtagaaaat ttcttatact     3120

tcagcttcag tgaagtgttg tctatgttaa taggcaagtt gaacctcggg ctaaagaaag     3180

gaattgtgtg gatggctgcc ttgactgaga caatatgggc aggggggcgt tcctgcttcc     3240

ccagaacaag ggcaggcttc ccaaaggcac cccttatttg ctgtctcttc gtaagcgtgg     3300

gcaccagtgg gttgatgtgg gaaacagtgc tggtgcaagt gtttaagttt tggataaact     3360

gaggattttg agaatcatta ttacattaca tagcaacaaa gaaacagatt gatataatct     3420

gtgtgaaata aattgctgag gagagggatt gtagggaaga agttgcttag ttaggcacct     3480

gggaagctca aatcatttag tttaaactgt aagtagagtt gtcttcccaa cgagaactgg     3540

tgattcctga tttcagaagg ctcatcagac ccctacaccc aagtctttta acacggagga     3600

agtttttcct tcatgaatac atacaagata ccgaactgaa gaaatctttt ctttgctcca     3660

acccccgctc ccccggcccc ccgaagctat taatagtcat tcaaatggca ctgcactctt     3720

tccaagcttt cctaagctaa atatggctcc aacaggtctg ggaactattg aatgcaatgt     3780

actctgaaat tccagcagct gtttacatgc ctgatgccta atgccatacg cctggaactt     3840

gctgagaact ctcggctgcc tctgtcctgg ggtactattg ctgaccagca gggtgtaggc     3900

gctgcttttg tttgagcttt gtagccacaa ggtctgatgt ctgttgtgaa cagcagctga     3960

cttcagcact ctggccagct tcctcaaact tgttagtggc ttgcattttg tcaatttttc     4020

tttgccattt cagtctttca agcagctgaa tcgcagaact gaaacaaaac acttatattg     4080

caaagttcct tccctttaaa atgagcttct ggattgcaga gatgattttt tatggtctta     4140

gcgtgcctca tgctgtagac cacatcgttg gagctctggg agagctctga gcagagaaag     4200

accttggtga tcccccctgg cccgatctat aggattgagg aatgaggctt gtagaggtgg     4260

cttgcccaag gtcacaacac tagagggtgg ttgagctggg ccaggaccca gacaagccct     4320

tttctctcag tctagtgagg cctctgggaa ggataggtga aaactataaa tagctgttca     4380

agatactctg agtaaaagtc agtggtgtta tctggaattt ctactgaaga ggaaatacag     4440

cagcaaaggt agactcatca gatggtgaaa gtgtcatctc ctttgtaatt tatactggtg     4500

agaggagggg aaggatgtgc tttcctattt ttacactggt acttcattca tccttgtctt     4560

aaacttaaga aatgaaatgc atcagggcac acatatacat agaaacagca cataagccat     4620

tttggatggc aattccagca ctcttttaat ggattggctt aatttttttt tctgatgcct     4680

ctctatgtgt ttgaaaagtt gtattgatag tcacacagag tgtactaaaa taacctaaaa     4740

ggtcttgaac ctccccttta cctctttaga acctctgaat ttggagacag ctagcaaacg     4800

gcaactgtag cctagcaaag atggcacagc accacaaagg gcaaatggag tcaactccct     4860

tccatgctct gaaggtcttg gccactctca tcagggttgg ctgtgtacta tccagcagct     4920

cacagtcagg agacctcccc tcctcagtcc ctcccatttc tttcttccgc aaggaaagaa     4980

cattgcatgt gggcgtgtgt gtgtgtatgt gtgtgcatgt gtgtgtgcat gtttcttctg     5040

tgcatagcag cataaagtta ggagatgatg actccagaat catcacaccc gctgtgcagg     5100

tcataggacc gcacacccga ggctgggagt ctaagtggta gatgcttcct ctccatgcgc     5160

agacagggct cccattattt gctaatgcct gcgacgtgct cagggaaggc aaaatctatt     5220

ccaaaggttt attttccctc tgttgaattg attctaatct acagtgctta ccctgctttt     5280

ggctcctacg aggcaaacta taaaaattct caaataaaat acagaggctt actctgcaaa     5340

gacacctgtg tgaatgacgt gctaaacatt cagcagaaac caaattagga tcaactctta     5400

acattttttc cctcttttgt ggctggaatg agttcccctg ggaaagaaaa tcgcccaagt     5460

gagaaactta tgccaaccac attcccatgc ccctacagtt acctgctggc ccagatcagc     5520

tctctgggtc tgcagagggc cgagacagga agcattatta agcagtataa tttcaaacac     5580

tttacttagt gccacagtgt gtctgcagta tctataagta cttccgctct gtcaaggaat     5640

acagactggc aggaagcaga taagcataat tgttttccaa taactcccca agtctcttgg     5700

aatatatatg tatctgaatc tctcagagga gagagttttc tctcttcttt ggccatttta     5760

gcctattttc caggaccttg tctagcagtg gctccatttt tccccgatgc atccaacttc     5820

cctccctgca ctcctcctcc ccgacagctg cctcaggaat aggtgaccct gctggccata     5880

ctgtgaatgc tgttctttca gctgtgacca atttgggggt gcagctgaga gtgaggtgct     5940

gtcagggctg aaaaggacgc acctcattct acatttggat gtgatgagga gcagggcagc     6000

caccagcttg gatcctaact tacattgggt ggtgcaacct ttctgacggg gcctgccaaa     6060

ctatcagtaa ttagccagcc tagacaatgt agcatgacta attattgctg tgtcaaagca     6120

attcaggaca agaaaaacat atctaaatga gaatgtttag atgtggtgag aaaagagctc     6180

tcaccacaat ttgaaacata taaaaagttg agttctttgc aggggagcca acgggggcat     6240

tgagggaagg gcaaaattca ccccagacag ccagtgcttg atcttgccaa acagtttaca     6300

ctttacctcc aaacctgcag ttctaagcta ctccactaaa ataatcatcc catcctcaaa     6360

gcagaccaac tccagcatcc catcggttct ggagggattt gatgcaaacc tttaaatgca     6420

ccaacagaga ggtaagccaa gctctcagga gggacaaaga tagatttcta tcttcagtgc     6480

tcttggggga tgtttgctcc tcatgagtgt ttaaacaaga tcatttccag gtgatttctt     6540

aacatataaa ttcctgcaaa ataggaccag cttctatagg tagcgaatgt gtaggtcata     6600

taattccttg tacagatgtg aatggatgca gactctttcc taatttgcct tgtaagccaa     6660

ataaaagtct gtctctactg tc                                              6682


<210>  34
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Gly Ala Pro Gly Pro Leu Arg Leu Ala Leu Leu Leu Leu Gly 
1               5                   10                  15      


Met Val Gly Arg Ala Gly Pro Arg Pro Gln Gly Ala Thr Val Ser Leu 
            20                  25                  30          


Trp Glu Thr Val Gln Lys Trp Arg Glu Tyr Arg Arg Gln Cys Gln Arg 
        35                  40                  45              


Ser Leu Thr Glu Asp Pro Pro Pro Ala Thr Asp Leu Phe Cys Asn Arg 
    50                  55                  60                  


Thr Phe Asp Glu Tyr Ala Cys Trp Pro Asp Gly Glu Pro Gly Ser Phe 
65                  70                  75                  80  


Val Asn Val Ser Cys Pro Trp Tyr Leu Pro Trp Ala Ser Ser Val Pro 
                85                  90                  95      


Gln Gly His Val Tyr Arg Phe Cys Thr Ala Glu Gly Leu Trp Leu Gln 
            100                 105                 110         


Lys Asp Asn Ser Ser Leu Pro Trp Arg Asp Leu Ser Glu Cys Glu Glu 
        115                 120                 125             


Ser Lys Arg Gly Glu Arg Ser Ser Pro Glu Glu Gln Leu Leu Phe Leu 
    130                 135                 140                 


Tyr Ile Ile Tyr Thr Val Gly Tyr Ala Leu Ser Phe Ser Ala Leu Val 
145                 150                 155                 160 


Ile Ala Ser Ala Ile Leu Leu Gly Phe Arg His Leu His Cys Thr Arg 
                165                 170                 175     


Asn Tyr Ile His Leu Asn Leu Phe Ala Ser Phe Ile Leu Arg Ala Leu 
            180                 185                 190         


Ser Val Phe Ile Lys Asp Ala Ala Leu Lys Trp Met Tyr Ser Thr Ala 
        195                 200                 205             


Ala Gln Gln His Gln Trp Asp Gly Leu Leu Ser Tyr Gln Asp Ser Leu 
    210                 215                 220                 


Ser Cys Arg Leu Val Phe Leu Leu Met Gln Tyr Cys Val Ala Ala Asn 
225                 230                 235                 240 


Tyr Tyr Trp Leu Leu Val Glu Gly Val Tyr Leu Tyr Thr Leu Leu Ala 
                245                 250                 255     


Phe Ser Val Leu Ser Glu Gln Trp Ile Phe Arg Leu Tyr Val Ser Ile 
            260                 265                 270         


Gly Trp Gly Val Pro Leu Leu Phe Val Val Pro Trp Gly Ile Val Lys 
        275                 280                 285             


Tyr Leu Tyr Glu Asp Glu Gly Cys Trp Thr Arg Asn Ser Asn Met Asn 
    290                 295                 300                 


Tyr Trp Leu Ile Ile Arg Leu Pro Ile Leu Phe Ala Ile Gly Val Asn 
305                 310                 315                 320 


Phe Leu Ile Phe Val Arg Val Ile Cys Ile Val Val Ser Lys Leu Lys 
                325                 330                 335     


Ala Asn Leu Met Cys Lys Thr Asp Ile Lys Cys Arg Leu Ala Lys Ser 
            340                 345                 350         


Thr Leu Thr Leu Ile Pro Leu Leu Gly Thr His Glu Val Ile Phe Ala 
        355                 360                 365             


Phe Val Met Asp Glu His Ala Arg Gly Thr Leu Arg Phe Ile Lys Leu 
    370                 375                 380                 


Phe Thr Glu Leu Ser Phe Thr Ser Phe Gln Gly Leu Met Val Ala Ile 
385                 390                 395                 400 


Leu Tyr Cys Phe Val Asn Asn Glu Val Gln Leu Glu Phe Arg Lys Ser 
                405                 410                 415     


Trp Glu Arg Trp Arg Leu Glu His Leu His Ile Gln Arg Asp Ser Ser 
            420                 425                 430         


Met Lys Pro Leu Lys Cys Pro Thr Ser Ser Leu Ser Ser Gly Ala Thr 
        435                 440                 445             


Ala Gly Ser Ser Met Tyr Thr Ala Thr Cys Gln Ala Ser Cys Ser 
    450                 455                 460             


<210>  35
<211>  8853
<212>  DNA
<213>  Homo sapiens

<400>  35
agtggcagga gcgccgcgca ccgccagccg cagggggcgt gggatggggg cggccgggga       60

ggggggcgcc cacactgact agagccaacc gcgcacttca aaagggtgtc ggtgccgcgc      120

tcccctcccg cggcccggga acttcaaagc gggccgtgct gccccggctg cctcgctctg      180

ctctggggcc tcgcagcccc ggcgcggccg cctggtggcg atgacccggg cgctctgctc      240

agcgctccgc caggctctcc tgctgctcgc agcggccgcc gagctctcgc caggactgaa      300

gtgtgtatgt cttttgtgtg attcttcaaa cttcacctgc caaacagaag gagcatgttg      360

ggcatcagtc atgctaacca atggaaaaga gcaggtgatc aaatcctgtg tctcccttcc      420

agaactgaat gctcaagtct tctgtcatag ttccaacaat gttaccaaaa ccgaatgctg      480

cttcacagat ttttgcaaca acataacact gcaccttcca acagcatcac caaatgcccc      540

aaaacttgga cccatggagc tggccatcat tattactgtg cctgtttgcc tcctgtccat      600

agctgcgatg ctgacagtat gggcatgcca gggtcgacag tgctcctaca ggaagaaaaa      660

gagaccaaat gtggaggaac cactctctga gtgcaatctg gtaaatgctg gaaaaactct      720

gaaagatctg atttatgatg tgaccgcctc tggatctggc tctggtctac ctctgttggt      780

tcaaaggaca attgcaagga cgattgtgct tcaggaaata gtaggaaaag gtagatttgg      840

tgaggtgtgg catggaagat ggtgtgggga agatgtggct gtgaaaatat tctcctccag      900

agatgaaaga tcttggtttc gtgaggcaga aatttaccag acggtcatgc tgcgacatga      960

aaacatcctt ggtttcattg ctgctgacaa caaagataat ggaacttgga ctcaactttg     1020

gctggtatct gaatatcatg aacagggctc cttatatgac tatttgaata gaaatatagt     1080

gaccgtggct ggaatgatca agctggcgct ctcaattgct agtggtctgg cacaccttca     1140

tatggagatt gttggtacac aaggtaaacc tgctattgct catcgagaca taaaatcaaa     1200

gaatatctta gtgaaaaagt gtgaaacttg tgccatagcg gacttagggt tggctgtgaa     1260

gcatgattca atactgaaca ctatcgacat acctcagaat cctaaagtgg gaaccaagag     1320

gtatatggct cctgaaatgc ttgatgatac aatgaatgtg aatatctttg agtccttcaa     1380

acgagctgac atctattctg ttggtctggt ttactgggaa atagcccgga ggtgttcagt     1440

cggaggaatt gttgaggagt accaattgcc ttattatgac atggtgcctt cagatccctc     1500

gatagaggaa atgagaaagg ttgtttgtga ccagaagttt cgaccaagta tcccaaacca     1560

gtggcaaagt tgtgaagcac tccgagtcat ggggagaata atgcgtgagt gttggtatgc     1620

caacggagcg gcccgcctaa ctgctcttcg tattaagaag actatatctc aactttgtgt     1680

caaagaagac tgcaaagcct aatgatgata attatgttaa aaagaaatct ctcatagctt     1740

tcttttccat tttccccttt atgtgaatgt ttttgccatt ttttttttgt tctacctcaa     1800

agataagaca gtacagtatt taagtgccca taaggcagca tgaaaagata actctaaagt     1860

taagcatggg caggagttga cttcatccaa tctctatgtt atgtttaatt ttattttgaa     1920

agcaacacct caactcatct ttttatttaa taaggaagaa atatattaca aaagtataaa     1980

ataagctcta taaaaatgtt atagtcatta agtttttatt ttacttgaac caagagcaca     2040

tgaatgaaca ggaaaagatg taaaaacatt tttttctgag atgaaaacat attaattaaa     2100

catgcaaatt agagcatgct atctttaggt gatgcaatct atgtttcccc ctttttaagt     2160

tagcaggact ttttaaaaat aaatattgct ctaaacttta atatatcgaa cgtgagagtg     2220

gagctgctta gtggaagatg taagtgaggt gggtgtccca tgtgcttggt ctccccttct     2280

gctgttctcc tgttcttcat aatccactac tgcagcagtc cctgaaccac taaacttgtt     2340

cctttcattt acaaaagaga tacctgacat cctgagacac tgagaaatgt cctgaagtca     2400

cacagctaat ggcagaactg gcactaggtc caaatcttgt gataatgaac accgtaaggt     2460

tagctagctt cctactttcc cttgaatagt gcttttctcc ctatgtaata tcttttatta     2520

tgatatttgt ggtttagaag gcatattgag ttattttgca gaatcataat ggacccgcac     2580

aaaatctcag aaccatatct gttgacattt tttctcatag aaatatcatg gttaccccat     2640

ttgttaatga gcattaatgt tttctgaaca cttccaaaga ttaatcaaac ataaatattc     2700

attgtctgaa aatgtcttta agatacaatt cagaggtccc tatttccttt gtacatacac     2760

acttagaaag aaaagacaga aaaggaagag gaaggaagga aatattttga gaatatattg     2820

agaagaatta agaaaactct tcaatgaagt gttaacaacc aaaccctaca gacggtatca     2880

gaaacagcaa atagatattc ctctaccctt tcacagtgag tgagtgagta cagaagaatg     2940

ctcatgatag ttttgccttc attctacttt ctgtggacac agagtaatga atatttaatg     3000

ggacattaaa tatgcccttc aaatctataa ttttactttg gtaaacgaga tttaacatga     3060

tgtcttttat gctcctaaaa catctttttt caaactccat tccttagaac attcttctac     3120

tgagatgatc caagaccaaa agtgttcttt ggtacttgct tataaagtga tagtacatgt     3180

tagcatataa tgtattttga agagtgaagt aaatgctatt gataacagta aaaaaaaaaa     3240

aaaaaactaa taacagtaaa gaaatgctac ttgatttttt tttaaactgg attgctcaga     3300

ttacctgatc gtggtggaac ccttttatta agaggagggg aaacttttta ctatcccata     3360

tttaactgtt ctataaagca aagcacagct tgggtaatag cgttctgaag gatatacttc     3420

tgtattttct catagagtac aatttagtga ttatgcttca tttcactatg gaaatatgtt     3480

actgaatcta tcttcatttt actgagttga aataaggaag gcaaaaaact gacagctatg     3540

gagtttgcgt gtacttccat actcgttaat gctctcatcc acttattaaa taatcataga     3600

gcacccatat cttgcttgcc acaatatcgg gtacaagagg gaatacaaag atagataggt     3660

cctgccctca gggattttaa agtctaattt gggaatggga atagggatgt gagtgtgtgg     3720

gggaagagat taaattgaca gataaaatac gaagtgggat gtcttgagtt ctgcatgaca     3780

gtgggtttct aggataggtc tgaaaattgc tttcatttgc aacacattta gaaagtagct     3840

ttatttggat attacagaca atctaaatat atcatcagtt tttaaaagtg cctatgtgaa     3900

gtgattttta aaaagagcct atgtgaaggg gtaatcttgc ttgttcttgt tactaatttc     3960

tcatagattg tttttctgca tatataagaa cgaaattatt tatttactat ggttgtacgt     4020

gcctcaaata aacaagaatg atatttcctg ttttatttac ttatgttggg taaatatgct     4080

tattgaattt ttaagagagg attttttacc atctccattt ttcttgtcat tatgttttgt     4140

agcttatttg agggtgtcta aatataattt catattttat tggttcaact ttcactctga     4200

agaaatccgt atgttagtac attttgaggt atttttcttg ttcttgtgtt gtttaactat     4260

gactcctaac tgagtagtct tatatttcaa ttacaaaata cattttttaa gaaagggaat     4320

agagcagcaa aaatgataag gaaaatgtta aaagttgtaa tatttccttt actcttaaca     4380

ggattatata tagaacatgc tcacttacaa aaataggatg atgaagttta gagcataagg     4440

caggcttctt gtatatactt atgctgtcaa atgttatatt gtttttaatg gagtcccatt     4500

gtgtaatatt tatttctttt acattttgtt ataagcaaaa aaaaaaaaaa ttctccttag     4560

gttatgttca gagtatcagt gttctttact ccttacagat attttggctt tggggtataa     4620

tacaagactt gggaaaacac tattatgaat tttcagtact gtataaagtg gtgatgggat     4680

ttaaatgcag catcactttc tgaaaataag agaaacatta tttgttgtca gtatttcagc     4740

atgaacttgt tgccttgtaa attttgcctt taagtttgta attggtacag attctgttgt     4800

atgctttctt ctatgtctaa aatatttggc atgtcacatc tagaattctt aatttatgtt     4860

ctgacttgag agttaagtga aacatgactg tcgtgcacta ttttaggcat agcacttgct     4920

tttcatcttt atactttcaa ttaactttgc attttaaatt tccatgattg tatgaaaata     4980

gtaacctggt tgcagtatct gaaaaaatta aaattagctt ttatttaaaa atgaaaatct     5040

acaatagatt cattaggtta gaagttccag aataatttat tattttatta cacctactat     5100

tgtagaatta ctaataaaac aaaacaaaac tactcctatt ttcctggaat tttgccacca     5160

tgtgacttat tggggcagag aaaactcagg gttgtctttg agtctgcaca aaagcaccag     5220

ggaacctgct tagcaaatcg tctgaaaaca gggagctgat gtttgccatt atacaaagtt     5280

tgagtaaaca acttaaaatt gcttgttagg gcatagtctt tgattgaaat aagtatgaga     5340

atgtatttgg ctaaataaat gtatttaaaa tatacaaatt ttatttccca ctggaaaatt     5400

aagaaagtag cagtaccaaa tgaataaaag ctggcagttg atgtcttcaa taatcattcc     5460

tttaaaataa attcacaaac acatcattac aagctactta gaaatgttta gtattcgtat     5520

cttaaaatgg caccattgtg gttttcaaag atattttaaa catcttttgt gaaacatact     5580

atttctgttt gacaatgctt tgttctagct ctgtgtgctg atacctacat ggagtttttc     5640

tgctatttta gtgaaaacag taattctttt atcttgagag ctgcttctaa ataacaaaaa     5700

agttaattgg aatgtaagtt tttaaaaaat gttaatatta aatagaattt ttataatatg     5760

ggcatttttc aaaacatttt aatgaaaata tatagatatt tgactttctt tttttcatct     5820

agccttgctt tatatttcat tatttttctc actttttttc ttaatattcc ctcactatct     5880

ttcaacatta tcattagttc ctaattttaa aaataactct tatttaactt aaccgtctgg     5940

aatttagcct tctaatgaaa gagaatccct tagtactctc agagattata taaagttatt     6000

ccaattttgt gtagatgacg aaaccaagga tcagagatta aatgactact agttactagc     6060

agaactctta tgaaagcctg gtggtgacac ccagcactgt tccctgccat atccccaact     6120

tttactgatt aaaaattaat tcgcatgcat ctaaacctac cttgaatgca cactaacgta     6180

atgtgccatt caatgatgat gataaaatcc cacttttctt tgggtttcta ctaaaataat     6240

ttactcactc agagtgaggt caatgagaaa aactaaacta ggctaagaaa gagttgtaga     6300

atggttgttg agctaagtag gcaaccactg gggtgctgat aaaattaatg gataaaattt     6360

aggaactgtg agagtataga atttcttagt gcaagtaatg attagagaag cttcctgaca     6420

tcccccaccc tttctgtaag gactgttctt tctctttgta ccttggaatg ggggtgaaag     6480

gtgatttgat agctgaattt gggactatgt ccagtgggat attatctaac ttttctctct     6540

ttctcttttt tttcccctca gtttctcatt agtttgtctt tggcattcat cttcttttag     6600

tgcattaaaa aatgtttggc agatctcatc aatcccaagt cactctataa ttcctgtatt     6660

tctttagttg tcgtttaacc tgtccaaact tctacacaat gaacttctta acaagatttt     6720

aagttctctg tataagaggt ttcacctcat aacttctcca gtaatccttc atttggcact     6780

atagagtatt tgttaatggc agagatgatt tttcttttaa aacctaaaaa gactagctgt     6840

tatttgtatt ctagctttta gctaacatat aaagaatgtc tacttttgct ttaatgctaa     6900

attccgcttg agaaatagta actgggaaag acaatttgaa atatatgccc cataatgtga     6960

ttgttaaatt tatttctgct gttccatacc attgctttgt tttgcttttg acaaactaag     7020

ccattatgct attagtttgg aatataatac tacagcaaaa ttaggtaaca atccctattt     7080

taaaattccc ctaacaataa tagaactgcc agcatacttt tctctttcag ttgtagatga     7140

atacattcga gagaatatga gctgtatttc atcctagatt ttaatatttt cagatgtgac     7200

tgtatttcct gatcattggt ccaagttgtc ctaaaagaaa tttttctctc cagacctaac     7260

agttttaact gcaagagttt actgtgggtt atgttaatct gaattttaat agggccacta     7320

agaatctgag tgccttagga gattaccctt atacccactg ccatcacatc cagtcaggcc     7380

tgttgtgctc tatataaatc ttcccagctg aggggcaggt gcgggctaaa atccaactgc     7440

aattggctcc cagacataat tttatatttt acagagaagc atcttattgg cttatatgtg     7500

tttaaagaat ggtctggctt atacatcttc agaaaatgag aattaaaaag tcaaaataat     7560

tcttgacatc tacagattga acaaagaact tagaagaaat aatactttat cttttcatcc     7620

tggcattcct gagagaagag aaattgattg tttatcatgt tggtttaatt tttcaaccca     7680

gacaatctgc agcaaggcac atggacccca attttgatat cgtccataca gttttcattc     7740

tatgcatgga gctaattact gactttgcct gtaaagagag gattgtgtgc ctaaattttg     7800

tctaacaaat gcaagcgtag aatgacattt actaatattt ctatttcttc cataggctaa     7860

ataatagtaa ctaagtattt ttaaggacac agcccttttt ttctctttat acaaaatgag     7920

agtatctgag ccaaaatatt aaattctagt tcttttccgc aatgactagt gtcaagctca     7980

tgtactcttc tgattctaga ctggagaaga ttattcaaac ttgatctgtg tttcaggttt     8040

ttaaatgtcc taaaaacaga aaattagatt cagatctcaa aaaaggaatt ttggattgac     8100

tttcaaagta ctaatactaa ttatactttt cttttggtag cgtgactctt cttataccta     8160

agaacatatt acaaatgtca aaaccattgc attttgacat tgcaaaacat gccttgaact     8220

cttgaactac tgtgaaaaga atcaccgttg taaagacttt ttgtaagcta gctgatactc     8280

ttaagtatgt aaaaagattg tctttcagcc gacaggccca aaggaatgta tataaggaag     8340

gaatatgaaa aaataaatta ggttttaaaa taggaattgg gcaataaact gtatcaaaaa     8400

tatgtagatg gattttagta gttgtaattt aaatgtggaa ggtgaagaga atttcaaact     8460

ccaaagagaa atgaatgata ttcagatgtt tcattaattt ctagtctgtg aaaatatgca     8520

ttttatagta atatgtatag acttatttta tttagaaata atagtgtttt agaatttatt     8580

aaaaactcag tgatagcctt tataccaaaa tgtttaactt taccaacagc aagtcataaa     8640

agtatttatt ttaaagcttt ttaatattat cgtgtaactt tcatctgtct tcagatgtaa     8700

ataattatct gcctaaatgt tatattttta tgtatgcatt ttctgaaaat gtattgtttt     8760

gtaaagtggg aaagataata aatcaagcac ttcttgcact tgtttctgtg aagcatatag     8820

aactctattt taaataaagg aagatgtgtc gta                                  8853


<210>  36
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Thr Arg Ala Leu Cys Ser Ala Leu Arg Gln Ala Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Ala Glu Leu Ser Pro Gly Leu Lys Cys Val Cys Leu Leu 
            20                  25                  30          


Cys Asp Ser Ser Asn Phe Thr Cys Gln Thr Glu Gly Ala Cys Trp Ala 
        35                  40                  45              


Ser Val Met Leu Thr Asn Gly Lys Glu Gln Val Ile Lys Ser Cys Val 
    50                  55                  60                  


Ser Leu Pro Glu Leu Asn Ala Gln Val Phe Cys His Ser Ser Asn Asn 
65                  70                  75                  80  


Val Thr Lys Thr Glu Cys Cys Phe Thr Asp Phe Cys Asn Asn Ile Thr 
                85                  90                  95      


Leu His Leu Pro Thr Ala Ser Pro Asn Ala Pro Lys Leu Gly Pro Met 
            100                 105                 110         


Glu Leu Ala Ile Ile Ile Thr Val Pro Val Cys Leu Leu Ser Ile Ala 
        115                 120                 125             


Ala Met Leu Thr Val Trp Ala Cys Gln Gly Arg Gln Cys Ser Tyr Arg 
    130                 135                 140                 


Lys Lys Lys Arg Pro Asn Val Glu Glu Pro Leu Ser Glu Cys Asn Leu 
145                 150                 155                 160 


Val Asn Ala Gly Lys Thr Leu Lys Asp Leu Ile Tyr Asp Val Thr Ala 
                165                 170                 175     


Ser Gly Ser Gly Ser Gly Leu Pro Leu Leu Val Gln Arg Thr Ile Ala 
            180                 185                 190         


Arg Thr Ile Val Leu Gln Glu Ile Val Gly Lys Gly Arg Phe Gly Glu 
        195                 200                 205             


Val Trp His Gly Arg Trp Cys Gly Glu Asp Val Ala Val Lys Ile Phe 
    210                 215                 220                 


Ser Ser Arg Asp Glu Arg Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln 
225                 230                 235                 240 


Thr Val Met Leu Arg His Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp 
                245                 250                 255     


Asn Lys Asp Asn Gly Thr Trp Thr Gln Leu Trp Leu Val Ser Glu Tyr 
            260                 265                 270         


His Glu Gln Gly Ser Leu Tyr Asp Tyr Leu Asn Arg Asn Ile Val Thr 
        275                 280                 285             


Val Ala Gly Met Ile Lys Leu Ala Leu Ser Ile Ala Ser Gly Leu Ala 
    290                 295                 300                 


His Leu His Met Glu Ile Val Gly Thr Gln Gly Lys Pro Ala Ile Ala 
305                 310                 315                 320 


His Arg Asp Ile Lys Ser Lys Asn Ile Leu Val Lys Lys Cys Glu Thr 
                325                 330                 335     


Cys Ala Ile Ala Asp Leu Gly Leu Ala Val Lys His Asp Ser Ile Leu 
            340                 345                 350         


Asn Thr Ile Asp Ile Pro Gln Asn Pro Lys Val Gly Thr Lys Arg Tyr 
        355                 360                 365             


Met Ala Pro Glu Met Leu Asp Asp Thr Met Asn Val Asn Ile Phe Glu 
    370                 375                 380                 


Ser Phe Lys Arg Ala Asp Ile Tyr Ser Val Gly Leu Val Tyr Trp Glu 
385                 390                 395                 400 


Ile Ala Arg Arg Cys Ser Val Gly Gly Ile Val Glu Glu Tyr Gln Leu 
                405                 410                 415     


Pro Tyr Tyr Asp Met Val Pro Ser Asp Pro Ser Ile Glu Glu Met Arg 
            420                 425                 430         


Lys Val Val Cys Asp Gln Lys Phe Arg Pro Ser Ile Pro Asn Gln Trp 
        435                 440                 445             


Gln Ser Cys Glu Ala Leu Arg Val Met Gly Arg Ile Met Arg Glu Cys 
    450                 455                 460                 


Trp Tyr Ala Asn Gly Ala Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys 
465                 470                 475                 480 


Thr Ile Ser Gln Leu Cys Val Lys Glu Asp Cys Lys Ala 
                485                 490             


<210>  37
<211>  4359
<212>  DNA
<213>  Homo sapiens

<400>  37
gggggccccg ccgccccagc agcccaggac agccccctct ccccgccccc agccccctcc       60

cccggcgcgg ccatggatgt gaccagcagc tcgggcggcg gcggcgaccc ccggcagatc      120

gaggagacca agccgctgct ggggggcgac gtgtcggccc ccgaaggcac gaagatgggc      180

gccgtgccct gccgccgggc tcttctgctt tgcaacggga tgaggtacaa actgctgcag      240

gagggcgaca ttcaggtctg tgtcatccgg cacccgcgga cctttctcag caagatcctc      300

acctcgaaat tcctgaggcg ctgggagccg caccacctaa cgctggccga caacagcctg      360

gcgtccgcca cgccaactgg gtacatggaa aactcagtct cctacagcgc aattgaagac      420

gttcagctgc tgtcctggga gaatgccccg aagtactgtt tacagctcac gattcctggg      480

ggaactgtct tactgcaggc tgccaatagc tacctgcgag accagtggtt ccattctctg      540

caatggaaga aaaagattta caaatataag aaagtgctga gtaacccaag ccgctgggaa      600

gttgtcttga aagagatccg gaccctggtg gacatggccc tgacatcccc cctgcaggat      660

gactccatca accaggcccc actggaaatc gtctcgaaac tgctctcaga gaacacaaac      720

ttgaccaccc aggagcatga aaacatcatt gtggcaatcg ctcctttgct ggaaaacaac      780

cacccaccac cagatctctg tgaattcttt tgcaagcact gcagagagcg gccccggtcc      840

atggtggtca tcgaggtgtt cacccccgtg gtgcagcgaa tcctcaagca taacatggac      900

tttgggaagt gcccgcgact gaggctgttt actcaggagt acatccttgc cttgaacgag      960

ctcaacgcgg ggatggaagt ggtgaagaag ttcattcaga gcatgcacgg ccccacaggg     1020

cactgccccc acccccgggt cctgcccaac ctggtggccg tgtgcctggc tgccatctac     1080

tcctgctatg aagagttcat caacagccgc gacaattccc caagcctgaa ggaaatccgg     1140

aacggctgcc agcagccgtg cgaccggaag cccactttac ctctgcgcct tctgcacccc     1200

agcccggacc tggtgtctca ggaagccacg ctgtctgagg cccggctcaa gtcggtggtc     1260

gtggcctcca gtgagatcca cgtggaggtg gaacgcacca gcactgccaa gccggcgctg     1320

acggccagcg caggcaacga cagcgagccc aacctcatcg actgcctcat ggtcagcccc     1380

gcctgcagca ccatgagcat cgagctgggc ccccaggccg accgcacgct cggctgctac     1440

gtggaaatcc tcaagctgct gtcagactat gatgactgga gaccgtctct ggccagtttg     1500

cttcaaccca ttccattccc caaagaagct ctcgcacatg agaagttcac caaggaactg     1560

aagtacgtga ttcagaggtt cgccgaagac cccaggcaag aggtccactc atgcctgctg     1620

agcgtgcggg ccggcaaaga tggctggttc cagctctaca gccccggagg ggtggcctgc     1680

gacgatgacg gggagctgtt cgccagcatg gtgcacatcc tcatgggctc ctgttacaag     1740

accaaaaaat tcctgctctc cctggcagaa aacaagctgg gtccctgcat gctcctggca     1800

ctgaggggga accagaccat ggtggagatc ctgtgcttga tgctggaata caacatcatc     1860

gacaacaacg acacccaact gcagatcatc tcaaccctgg agagcacaga cgtggggaag     1920

cgcatgtacg agcagctgtg tgaccggcag cgggagctga aggagctgca aaggaaaggc     1980

gggcccacca ggctaacact gccctccaag tccacagacg ctgacttggc tcgtttgctg     2040

agctccggct ccttcggaaa cctggagaac ctcagtttgg ccttcaccaa tgtaaccagt     2100

gcctgcgccg agcacctcat caaactgcct tcgctcaagc agctgaacct gtggtccact     2160

cagtttggag acgctggcct tcggctcctg tcggaacacc tcaccatgct ccaggtgctg     2220

aacctgtgcg agaccccggt cacagacgct ggcctgctgg ccctgagctc catgaagagt     2280

ctctgcagtt taaacatgaa cagcaccaag ctctcagctg acacctacga agatctgaag     2340

gccaagcttc ccaatttgaa ggaagtggac gtccgctaca ccgaagcctg gtgaagctcc     2400

cagctcaagg caggaagacg tttgcaaccg cgacaaaata actcttgact aacagccgca     2460

gagcagccgg tcctggggtc ccaccctggt gccctggctg tgagatagat ggggagtctt     2520

tctgggggcg gaggggggag ggggtgggga gggggcccac aagcacgccc agcccccgcc     2580

gaattctttt agcttcgtaa ttggaacctt tgacctgatc taaagtggac tttgtagcaa     2640

caagaggagc atcagcgggt cggggagggg tttgggggtg ggctgggggg tgggggaccc     2700

tttgtggatt ttctttgcct ttgtgtttga tgccgtcgtg tgggaaaagt caactccgat     2760

gccaccattg cgggccggac gaaggatgct ttcttcctag aggctccgag ctgagctgcg     2820

aactcgcccc ccgcccttgg gacaagaaga cccagtcaca tcactgcacc cgtcctgtgt     2880

cctcaccatt gctatgcaaa gtgattcttg ttgtacataa gatttaaata atgcacctat     2940

ttaagacatg ttgacaaatt gcgggtctgg gacccgcctc ttatttatga agtctttgac     3000

cgtccccccc gcccgacccc accgccctcc cgcccccacc tggcgtgtag tactgtataa     3060

accagtcagc tgtcgggtta gtggtagtat tattgttatt tttttaaagg aaacaaacag     3120

acaacaaaaa gaagaaaaaa aaaaagaacc tccttggaaa aattaattgc tttttcgtaa     3180

tggattctct atgctaatgc tctctcgtct gtctgtctgt ctgcccactc ccccacccac     3240

cactgtgcgt ttctgatttc caaatgtctc caactccctc acgaggtggg gctcaggctg     3300

gaggaggagg gattaagatc cccttgctcc actaaggccc aagctctttc tctcggcacc     3360

ttttagactt gaatgggagg ctgctaaccc gccctctcca gtccaccccg gtaaaagagc     3420

tgttccccac ccccagggag ctcctgtccc tgtcagcctt tgctgtcccc tgtccccaac     3480

ggagactctg tcacccctgg gctccccctg ccatcgtgtg cttcacgtgg ccccatgcat     3540

gcccgcctct ctgcatggtc tcttgggaaa agagagatgt gtcgcctccg ccagtccgac     3600

tgccctcccc accccacccc cgccaccccc cacatgtgac cactgcaacg aagacactcc     3660

ttctgtcccc acctgctccg aagacaaacc aacctccgtt tcttttataa acagtcggct     3720

ttttcttaat aagccctcac tgtacagaac agcccgttga tggtttattt ggggtccccc     3780

tctcccccca gccctttttt ctgttggttt agcacaaata cttccctcct ccggcacctc     3840

caaacctacc ccacagtcag tgtacttgtt ttatatatat ttaatcttat tcaatggaaa     3900

ccatgctttt gtcgttttat actttgctag gtagacttta ttaccccccc actatgccct     3960

cattttttta aaaaaggaaa aaaaaaagaa actgggttcc agtcttaatt cattttccgt     4020

gccaggtttt atttcgtgtg tgtgtgagtg tgttctgttt tgtgttttgt tttttgttgt     4080

tgtttttagt tgtttggttt tcttttcttt cccccctccg gtcccatact tcacagcact     4140

ctggtgcggg aagaagcaga agcaaaaaaa ataaaaataa aaaaataaat aaaaataaaa     4200

aaaataaaaa aggaaaaaaa aaaaagaaga aacaagacat gccacctttc ccctcgcact     4260

gttgcttttc ctgatggtta atactactgt cacgtagctg tgtacaaaga gatgtgaaat     4320

actttcaggc aaaaataaac tgtaagtgac tcatcaaaa                            4359


<210>  38
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Val Thr Ser Ser Ser Gly Gly Gly Gly Asp Pro Arg Gln Ile 
1               5                   10                  15      


Glu Glu Thr Lys Pro Leu Leu Gly Gly Asp Val Ser Ala Pro Glu Gly 
            20                  25                  30          


Thr Lys Met Gly Ala Val Pro Cys Arg Arg Ala Leu Leu Leu Cys Asn 
        35                  40                  45              


Gly Met Arg Tyr Lys Leu Leu Gln Glu Gly Asp Ile Gln Val Cys Val 
    50                  55                  60                  


Ile Arg His Pro Arg Thr Phe Leu Ser Lys Ile Leu Thr Ser Lys Phe 
65                  70                  75                  80  


Leu Arg Arg Trp Glu Pro His His Leu Thr Leu Ala Asp Asn Ser Leu 
                85                  90                  95      


Ala Ser Ala Thr Pro Thr Gly Tyr Met Glu Asn Ser Val Ser Tyr Ser 
            100                 105                 110         


Ala Ile Glu Asp Val Gln Leu Leu Ser Trp Glu Asn Ala Pro Lys Tyr 
        115                 120                 125             


Cys Leu Gln Leu Thr Ile Pro Gly Gly Thr Val Leu Leu Gln Ala Ala 
    130                 135                 140                 


Asn Ser Tyr Leu Arg Asp Gln Trp Phe His Ser Leu Gln Trp Lys Lys 
145                 150                 155                 160 


Lys Ile Tyr Lys Tyr Lys Lys Val Leu Ser Asn Pro Ser Arg Trp Glu 
                165                 170                 175     


Val Val Leu Lys Glu Ile Arg Thr Leu Val Asp Met Ala Leu Thr Ser 
            180                 185                 190         


Pro Leu Gln Asp Asp Ser Ile Asn Gln Ala Pro Leu Glu Ile Val Ser 
        195                 200                 205             


Lys Leu Leu Ser Glu Asn Thr Asn Leu Thr Thr Gln Glu His Glu Asn 
    210                 215                 220                 


Ile Ile Val Ala Ile Ala Pro Leu Leu Glu Asn Asn His Pro Pro Pro 
225                 230                 235                 240 


Asp Leu Cys Glu Phe Phe Cys Lys His Cys Arg Glu Arg Pro Arg Ser 
                245                 250                 255     


Met Val Val Ile Glu Val Phe Thr Pro Val Val Gln Arg Ile Leu Lys 
            260                 265                 270         


His Asn Met Asp Phe Gly Lys Cys Pro Arg Leu Arg Leu Phe Thr Gln 
        275                 280                 285             


Glu Tyr Ile Leu Ala Leu Asn Glu Leu Asn Ala Gly Met Glu Val Val 
    290                 295                 300                 


Lys Lys Phe Ile Gln Ser Met His Gly Pro Thr Gly His Cys Pro His 
305                 310                 315                 320 


Pro Arg Val Leu Pro Asn Leu Val Ala Val Cys Leu Ala Ala Ile Tyr 
                325                 330                 335     


Ser Cys Tyr Glu Glu Phe Ile Asn Ser Arg Asp Asn Ser Pro Ser Leu 
            340                 345                 350         


Lys Glu Ile Arg Asn Gly Cys Gln Gln Pro Cys Asp Arg Lys Pro Thr 
        355                 360                 365             


Leu Pro Leu Arg Leu Leu His Pro Ser Pro Asp Leu Val Ser Gln Glu 
    370                 375                 380                 


Ala Thr Leu Ser Glu Ala Arg Leu Lys Ser Val Val Val Ala Ser Ser 
385                 390                 395                 400 


Glu Ile His Val Glu Val Glu Arg Thr Ser Thr Ala Lys Pro Ala Leu 
                405                 410                 415     


Thr Ala Ser Ala Gly Asn Asp Ser Glu Pro Asn Leu Ile Asp Cys Leu 
            420                 425                 430         


Met Val Ser Pro Ala Cys Ser Thr Met Ser Ile Glu Leu Gly Pro Gln 
        435                 440                 445             


Ala Asp Arg Thr Leu Gly Cys Tyr Val Glu Ile Leu Lys Leu Leu Ser 
    450                 455                 460                 


Asp Tyr Asp Asp Trp Arg Pro Ser Leu Ala Ser Leu Leu Gln Pro Ile 
465                 470                 475                 480 


Pro Phe Pro Lys Glu Ala Leu Ala His Glu Lys Phe Thr Lys Glu Leu 
                485                 490                 495     


Lys Tyr Val Ile Gln Arg Phe Ala Glu Asp Pro Arg Gln Glu Val His 
            500                 505                 510         


Ser Cys Leu Leu Ser Val Arg Ala Gly Lys Asp Gly Trp Phe Gln Leu 
        515                 520                 525             


Tyr Ser Pro Gly Gly Val Ala Cys Asp Asp Asp Gly Glu Leu Phe Ala 
    530                 535                 540                 


Ser Met Val His Ile Leu Met Gly Ser Cys Tyr Lys Thr Lys Lys Phe 
545                 550                 555                 560 


Leu Leu Ser Leu Ala Glu Asn Lys Leu Gly Pro Cys Met Leu Leu Ala 
                565                 570                 575     


Leu Arg Gly Asn Gln Thr Met Val Glu Ile Leu Cys Leu Met Leu Glu 
            580                 585                 590         


Tyr Asn Ile Ile Asp Asn Asn Asp Thr Gln Leu Gln Ile Ile Ser Thr 
        595                 600                 605             


Leu Glu Ser Thr Asp Val Gly Lys Arg Met Tyr Glu Gln Leu Cys Asp 
    610                 615                 620                 


Arg Gln Arg Glu Leu Lys Glu Leu Gln Arg Lys Gly Gly Pro Thr Arg 
625                 630                 635                 640 


Leu Thr Leu Pro Ser Lys Ser Thr Asp Ala Asp Leu Ala Arg Leu Leu 
                645                 650                 655     


Ser Ser Gly Ser Phe Gly Asn Leu Glu Asn Leu Ser Leu Ala Phe Thr 
            660                 665                 670         


Asn Val Thr Ser Ala Cys Ala Glu His Leu Ile Lys Leu Pro Ser Leu 
        675                 680                 685             


Lys Gln Leu Asn Leu Trp Ser Thr Gln Phe Gly Asp Ala Gly Leu Arg 
    690                 695                 700                 


Leu Leu Ser Glu His Leu Thr Met Leu Gln Val Leu Asn Leu Cys Glu 
705                 710                 715                 720 


Thr Pro Val Thr Asp Ala Gly Leu Leu Ala Leu Ser Ser Met Lys Ser 
                725                 730                 735     


Leu Cys Ser Leu Asn Met Asn Ser Thr Lys Leu Ser Ala Asp Thr Tyr 
            740                 745                 750         


Glu Asp Leu Lys Ala Lys Leu Pro Asn Leu Lys Glu Val Asp Val Arg 
        755                 760                 765             


Tyr Thr Glu Ala Trp 
    770             


<210>  39
<211>  6324
<212>  DNA
<213>  Homo sapiens

<400>  39
gtcgtccgtt cccaagctgg tttgaaacta ggggtcgggc tcggccgtcg tcgttgtttg       60

tcgccgcatc cccgcttccg ggttaggccg ttcctgcccg ccccctcctc tcctcccttc      120

ggacccatag atctcaggct cggctccccg cccgccgcag cccactgttg acccggcccg      180

tactgcggcc ccgtggccac catgtccctg cacggcaaac ggaaggagat ctacaagtat      240

gaagcgccct ggacagtcta cgcgatgaac tggagtgtgc ggcccgataa gcgctttcgc      300

ttggcgctgg gcagcttcgt ggaggagtac aacaacaagg ttcagcttgt tggtttagat      360

gaggagagtt cagagtttat ttgcagaaac acctttgacc acccataccc caccacaaag      420

ctcatgtgga tccctgacac aaaaggcgtc tatccagacc tactggcaac aagcggtgac      480

tatctccgtg tgtggagggt tggtgaaaca gagaccaggc tggagtgttt gctaaacaat      540

aataagaact ctgatttctg tgctcccctg acctcctttg actggaatga ggtggatcct      600

tatcttttag gtacctcaag cattgatacg acatgcacca tctgggggct ggagacaggg      660

caggtgttag ggcgagtgaa tctcgtgtct ggccacgtga agacccagct gatcgcccat      720

gacaaagagg tctatgatat tgcatttagc cgggccgggg gtggcaggga catgtttgcc      780

tctgtgggtg ctgatggctc ggtgcggatg tttgacctcc gccatctaga acacagcacc      840

atcatttacg aagacccaca gcatcaccca ctgcttcgcc tctgctggaa caagcaggac      900

cctaactacc tggccaccat ggccatggat ggaatggagg tggtgattct agatgtccgg      960

gttccctgca cacctgtcgc caggttaaac aaccatcgag catgtgtcaa tggcattgct     1020

tgggccccac attcatcctg ccacatctgc actgcagcgg atgaccacca ggctctcatc     1080

tgggacatcc agcaaatgcc ccgagccatt gaggacccta tcctggccta cacagctgaa     1140

ggagagatca acaatgtgca gtgggcatca actcagcccg actggatcgc catctgctac     1200

aacaactgcc tggagatact cagagtgtag tgttggtggc gctgtgccca cgaggcaggg     1260

gcttttgtat ttcctgcctc tgccccaccc ccaaagtaag aagaaacatg tttccagtgg     1320

ccagtatgtc tttcattgct ttgcacccac tgttaccaga agctgctcta ggagttcctg     1380

gccagtcacc ccatcgccct ctgtggcaga ctcagtgctg tgtggcgcct cctcagccca     1440

gggctgagtt ttaagatttt ctctcctttc ctcttctcct ttggttcctc aattaaaaaa     1500

tgtgtgtata tttgtttgtc aggcgttgtg ttgaggagca gttcacgcac tggctgtgtc     1560

tattcctctg cccaggtgtc tctgtttgct gcccaaggca gcagttcatg tctcgtccat     1620

gtccatgttc gtgttagcac ttacgtggga acaaatacca atttgtcttt tctcctagta     1680

tcagtgtgtt taacaaattt taactttgta tatttgttat ctatcaggct aattttttta     1740

tgaaaagaat tttactctcc tgcttcattt ctttgtctta tagtcctccc tctttgcacc     1800

ttcttctctt ccctcagtgc ctggagctgg tactgggccc ctggccccat gagcagtttg     1860

ccttcttgag tcactgcctg tgtagtacat acctgaccgg gagtccaaac caccttggtg     1920

ctctgaagtc cactgactca tcacaccttt cttagcctgg ctcctctcaa gggcattctg     1980

ggcttgtaaa cagacatagg aagcctctgt ttaccctgaa gcaccactgt ccagcccatt     2040

ggttcccact ggcagcatgg tagagctgag agaaacaggc tctcagggta cctgacttga     2100

ggggaatcgt ttcatgaagc tgaacttcaa gcatatttcc agtacattct ttcagagtct     2160

gtttttccat ccaaatataa gccccaggcc attccactta gtgtcttttc aatgataggc     2220

aagaatgata tctgagttga acttcggtgc ttctgttgtt tgagtttact gtgcctggtg     2280

gtatattggg cattctttgg attgagtgtt ctgaggtgag agagtcttcc cgaggcatcc     2340

tgtctgtgct tccaaccctg aacaagacct tacatgagag atggactgat ggactgcggc     2400

aatcctgggc tgtcaagtgg atagatagtt aaaaagcatt atactgtggg taatgaaaag     2460

ggaggaaaaa aaaagaagga aaaggaatta tagaccccca gggtcagcca gttaagagct     2520

ctacccacac ctgtcaaccc ctctctcccc cagtttaggt tctgagcagt attggacttg     2580

tagcctgcag ttgtcttttg acttgcaggc cgcaggtgtc tttctgttat gtgaatgagt     2640

tccatggagg ggcatatgtg tgattccacc gttagatgag cccttggggc aggcagtttg     2700

ggatgtgctc ttgggggaaa gttggctgtt tccttgcgct ctgctcctac ccgaaggttt     2760

ttaagtccct ctgaattgct catctgagat tagtagagta gcaggcctga aggatgatgg     2820

ttttgtcctc tttggttctc acctgcttga gaagtaaaac agtaactttg ttcttctggg     2880

cccttaagct tttttggtta agtcttcctt ttcagaagta gatgtcatta tatgccaaaa     2940

gtctagctct ttgctttacc atacagggac ctgtcccaaa gaaaaaggct ctttttttag     3000

ccagcatatt tccccttcta cccttttact ttgttgttct gattttagga ctctggctgg     3060

ccatgtgctt gtggttgcct ctcctgcatt tgccactgga tttgcactgc atcgtttgga     3120

gatacaaagc gagcagttct tggtcagaac cctcctctgc ttttcattgt gtttgataat     3180

ggttactggg tccttctctc aagggtagca aggccaagct gatggctgct tgtttaggag     3240

gccatcagtt ccttcctgtg gagaagggtc tgaaatggaa gtcagtggta gaaggggctg     3300

gtctgctggg cagggcttac atccactgag ttctaagatt cctttcctga tctgcaccta     3360

cgcctggtct gtatggtgga atttgtcagc tggaactcag aaacaacaac ttgaaaaaaa     3420

aataataatt agaacatatt tgcataagat agctatttac tctggaaacc aacaactttt     3480

gagatttccc ttgccctgtg gacgcccagc tcctgtcatc cttccttagg tcctgcagta     3540

cagtcttccc ctgaatgcca ccggggaccc agggggactc caccccccta agcaagcaca     3600

cacatactca cagttgatga gttgctggtc tttgagtccc agctctctta ccctcccttt     3660

actccaccag cccgacgacc catgactgag gaggggattt ctacagtctc aggatttaga     3720

aagtctgtaa gccatccatg ctccagaaag caccgatctg ttgtagttgc aaaaacaact     3780

ctgtaatttg ttgaggttct caaactgaca gccagcgaga ctgggtggga ggccctggat     3840

ctgttctccc tgactgcggg aggagcagcc actaggactt tagcaggaag cccacatgga     3900

ggctccgcca ggctgtggcc cagctggtga tggccctttt gctcctggca gcctgaggca     3960

cagctgcctg tattgtcctc atctgttctg actgaaggat ggaggtgctg aataaattag     4020

gcctcaggcc tctaccacca gagagctgga gaatgggtcc acgtcattca aggacctgaa     4080

ttttttatgc tcaggagcat tggaatcctc ttcttccagg gaggaattag cctgcaaggt     4140

taggacttga agagggaagg tatttaataa ctgggcgagg atgggtgtgg tggctcacac     4200

ctgtaatccc agcattttgg gaggctgagg tggccagatc ccaaggtcag aagatcgaga     4260

ccatcctggc taacatggtg aaaccccatc tctactaaaa atacaaaaaa aaattagccg     4320

ggggtggtgg cgggtacctg tagtcctagc tacttgggag gctgaggcag gagaatggcg     4380

tgaacctggg aggtggagct tgcagtgagc caagatcgtg ccactgcact ccagcctggg     4440

cgacagagca agactccgtc tcaaaaaata aaaaaaaaaa aaaaataggt gaaaattcct     4500

tataaatcca ggattggctc tgagagaact ggctaagatt caggaagaaa caaaaaattc     4560

agaatcctac aaggttttga tgacaattag ggccaaaatt ttaggaggag atgtaggatg     4620

caggagaaaa ttaaagtgtt ttctttatat cagaggagga aatagtagag gtcagtgaag     4680

gtctggggta gggaaacatt cagactgtcc attgcatggc tgtggagtga gactgccctt     4740

agcctgggtc agccttcctg ggccataaat tgggcatccg tgatgctagg taactgtggg     4800

aacaaaatga cagcttagag cagccatggg tgatgtttgg tggtaaaaaa cctacaggcg     4860

tttggggtcc catgattgtt ccagaccatg actcttcctg gttgtgggtt tgttacagag     4920

caggagaagc agaggttatg acagttatgc agactttccc cctccttttt ctcttttctc     4980

ttccccttgc ttttccactg tttcttcctg ctgccacctg ggccttgaat tcctgggctg     5040

tgaagacatg tagcagctgc agggtttacc acacgtggga gggcagccca gtactgtccc     5100

tctgccttcc ccactttgag aatatggcag cccctttcat tcctggcttg gggtagggga     5160

gaccattgaa gtagaagcct caaagcagac ttttcccttt actgtgtgta ctccaggacg     5220

aagaaggaag atcatgcttg atacttagat tggttttccc agggaagagg gcggagcaga     5280

gcaaagtcac tgtgaaccct gggccaggcc ctggctgggc cagctcctga gagcgtctcg     5340

tgttgcagac ccttgcccac ttcacccacc tgcaccttct ccccctctca cagtgtcact     5400

gctgctaatg gtcaaagtca aatgtgtggc cacatgggat gggccaggtc ctctcaggct     5460

actttctgga tgtcattttt aaaatatgga aacatgcagg tgccttccca aagaggcttg     5520

gactggtata tccaacgaga aacaaataag ctaaagaaag tttaaactca agaagaaaga     5580

tgttgacagt ctatgtaaca gctggaaagt ttataggcac ccacctttgg gacaacccag     5640

tgattatgaa catgtgatat ctactattta aaagaaatgt tctcaccttg ggttgattgt     5700

ggtataccat gtgttatgaa aattgttgag ctgaagcttt gaatcgattt agttgagtct     5760

gactcacttg ctttggttcc tgtgtatttt actacccctc ttgtcagtga ccttccttcc     5820

ccaccccacc cagagtgaat ttgtagcatg attgtataaa cctctatgta gaaaatggag     5880

atttcttgct ctgaaatgtt aagctctaac tgatccattt ctgtgtcctt tagcctagta     5940

tgtctgaact tccattcttg ttatatattt aaactttccc tctatattat aggttttgtg     6000

gcatccacgg tcaggtgtag aggaagctgc cccttgcaga actgtactgt aatatttttc     6060

ttttataaat attttcacag gactgattgt acacagggct tgtaataaaa ttttaacact     6120

gtgctgtgaa acaactatgg ggaatctcca ttgaaggcta cttcatgggc acctgaaagt     6180

ggagtgttat agctatgact ttctatttct tgtttcctaa gtaaattaaa cctaattttc     6240

accctttcat tctgtttcag cctcctgtat aagaagtacc gtattttctg cccatcatac     6300

tttgtaataa aacttgaaca tgta                                            6324


<210>  40
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Leu His Gly Lys Arg Lys Glu Ile Tyr Lys Tyr Glu Ala Pro 
1               5                   10                  15      


Trp Thr Val Tyr Ala Met Asn Trp Ser Val Arg Pro Asp Lys Arg Phe 
            20                  25                  30          


Arg Leu Ala Leu Gly Ser Phe Val Glu Glu Tyr Asn Asn Lys Val Gln 
        35                  40                  45              


Leu Val Gly Leu Asp Glu Glu Ser Ser Glu Phe Ile Cys Arg Asn Thr 
    50                  55                  60                  


Phe Asp His Pro Tyr Pro Thr Thr Lys Leu Met Trp Ile Pro Asp Thr 
65                  70                  75                  80  


Lys Gly Val Tyr Pro Asp Leu Leu Ala Thr Ser Gly Asp Tyr Leu Arg 
                85                  90                  95      


Val Trp Arg Val Gly Glu Thr Glu Thr Arg Leu Glu Cys Leu Leu Asn 
            100                 105                 110         


Asn Asn Lys Asn Ser Asp Phe Cys Ala Pro Leu Thr Ser Phe Asp Trp 
        115                 120                 125             


Asn Glu Val Asp Pro Tyr Leu Leu Gly Thr Ser Ser Ile Asp Thr Thr 
    130                 135                 140                 


Cys Thr Ile Trp Gly Leu Glu Thr Gly Gln Val Leu Gly Arg Val Asn 
145                 150                 155                 160 


Leu Val Ser Gly His Val Lys Thr Gln Leu Ile Ala His Asp Lys Glu 
                165                 170                 175     


Val Tyr Asp Ile Ala Phe Ser Arg Ala Gly Gly Gly Arg Asp Met Phe 
            180                 185                 190         


Ala Ser Val Gly Ala Asp Gly Ser Val Arg Met Phe Asp Leu Arg His 
        195                 200                 205             


Leu Glu His Ser Thr Ile Ile Tyr Glu Asp Pro Gln His His Pro Leu 
    210                 215                 220                 


Leu Arg Leu Cys Trp Asn Lys Gln Asp Pro Asn Tyr Leu Ala Thr Met 
225                 230                 235                 240 


Ala Met Asp Gly Met Glu Val Val Ile Leu Asp Val Arg Val Pro Cys 
                245                 250                 255     


Thr Pro Val Ala Arg Leu Asn Asn His Arg Ala Cys Val Asn Gly Ile 
            260                 265                 270         


Ala Trp Ala Pro His Ser Ser Cys His Ile Cys Thr Ala Ala Asp Asp 
        275                 280                 285             


His Gln Ala Leu Ile Trp Asp Ile Gln Gln Met Pro Arg Ala Ile Glu 
    290                 295                 300                 


Asp Pro Ile Leu Ala Tyr Thr Ala Glu Gly Glu Ile Asn Asn Val Gln 
305                 310                 315                 320 


Trp Ala Ser Thr Gln Pro Asp Trp Ile Ala Ile Cys Tyr Asn Asn Cys 
                325                 330                 335     


Leu Glu Ile Leu Arg Val 
            340         


<210>  41
<211>  1787
<212>  DNA
<213>  Homo sapiens

<400>  41
gaggagtgga gatggcggcg gcggcggctc aggggggcgg gggcggggag ccccgtagaa       60

ccgagggggt cggcccgggg gtcccggggg aggtggagat ggtgaagggg cagccgttcg      120

acgtgggccc gcgctacacg cagttgcagt acatcggcga gggcgcgtac ggcatggtca      180

gctcggccta tgaccacgtg cgcaagactc gcgtggccat caagaagatc agccccttcg      240

aacatcagac ctactgccag cgcacgctcc gggagatcca gatcctgctg cgcttccgcc      300

atgagaatgt catcggcatc cgagacattc tgcgggcgtc caccctggaa gccatgagag      360

atgtctacat tgtgcaggac ctgatggaga ctgacctgta caagttgctg aaaagccagc      420

agctgagcaa tgaccatatc tgctacttcc tctaccagat cctgcggggc ctcaagtaca      480

tccactccgc caacgtgctc caccgagatc taaagccctc caacctgctc atcaacacca      540

cctgcgacct taagatttgt gatttcggcc tggcccggat tgccgatcct gagcatgacc      600

acaccggctt cctgacggag tatgtggcta cgcgctggta ccgggcccca gagatcatgc      660

tgaactccaa gggctatacc aagtccatcg acatctggtc tgtgggctgc attctggctg      720

agatgctctc taaccggccc atcttccctg gcaagcacta cctggatcag ctcaaccaca      780

ttctgggcat cctgggctcc ccatcccagg aggacctgaa ttgtatcatc aacatgaagg      840

cccgaaacta cctacagtct ctgccctcca agaccaaggt ggcttgggcc aagcttttcc      900

ccaagtcaga ctccaaagcc cttgacctgc tggaccggat gttaaccttt aaccccaata      960

aacggatcac agtggaggaa gcgctggctc acccctacct ggagcagtac tatgacccga     1020

cggatgagcc agtggccgag gagcccttca ccttcgccat ggagctggat gacctaccta     1080

aggagcggct gaaggagctc atcttccagg agacagcacg cttccagccc ggagtgctgg     1140

aggcccccta gcccagacag acatctctgc accctggggc ctggacctgc ctcctgcctg     1200

cccctctccc gccagactgt tagaaaatgg acactgtgcc cagcccggac cttggcagcc     1260

caggccgggg tggagcatgg gcctggccac ctctctcctt tgctgaggcc tccagcttca     1320

ggcaggccaa ggccttctcc tccccacccg ccctccccac ggggcctcgg gacctcaggt     1380

ggccccagtt caatctcccg ctgctgctgc tgcgccctta ccttccccag cgtcccagtc     1440

tctggcagtt ctggaatgga agggttctgg ctgccccaac ctgctgaagg gcagaggtgg     1500

agggtggggg gcgctgagta gggactcagg gccatgcctg cccccctcat ctcattcaaa     1560

ccccacccta gtttccctga aggaacattc cttagtctca agggctagca tccctgagga     1620

gccaggccgg gccgaatccc ctccctgtca aagctgtcac ttcgcgtgcc ctcgctgctt     1680

ctgtgtgtgg tgagcagaag tggagctggg gggcgtggag agcccggcgc ccctgccacc     1740

tccctgaccc gtctaatata taaatataga gatgtgtcta tggctga                   1787


<210>  42
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ala Ala Ala Ala Gln Gly Gly Gly Gly Gly Glu Pro Arg Arg 
1               5                   10                  15      


Thr Glu Gly Val Gly Pro Gly Val Pro Gly Glu Val Glu Met Val Lys 
            20                  25                  30          


Gly Gln Pro Phe Asp Val Gly Pro Arg Tyr Thr Gln Leu Gln Tyr Ile 
        35                  40                  45              


Gly Glu Gly Ala Tyr Gly Met Val Ser Ser Ala Tyr Asp His Val Arg 
    50                  55                  60                  


Lys Thr Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr 
65                  70                  75                  80  


Tyr Cys Gln Arg Thr Leu Arg Glu Ile Gln Ile Leu Leu Arg Phe Arg 
                85                  90                  95      


His Glu Asn Val Ile Gly Ile Arg Asp Ile Leu Arg Ala Ser Thr Leu 
            100                 105                 110         


Glu Ala Met Arg Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp 
        115                 120                 125             


Leu Tyr Lys Leu Leu Lys Ser Gln Gln Leu Ser Asn Asp His Ile Cys 
    130                 135                 140                 


Tyr Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
145                 150                 155                 160 


Asn Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Ile Asn Thr 
                165                 170                 175     


Thr Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Ile Ala Asp 
            180                 185                 190         


Pro Glu His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg 
        195                 200                 205             


Trp Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys 
    210                 215                 220                 


Ser Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser 
225                 230                 235                 240 


Asn Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His 
                245                 250                 255     


Ile Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile 
            260                 265                 270         


Ile Asn Met Lys Ala Arg Asn Tyr Leu Gln Ser Leu Pro Ser Lys Thr 
        275                 280                 285             


Lys Val Ala Trp Ala Lys Leu Phe Pro Lys Ser Asp Ser Lys Ala Leu 
    290                 295                 300                 


Asp Leu Leu Asp Arg Met Leu Thr Phe Asn Pro Asn Lys Arg Ile Thr 
305                 310                 315                 320 


Val Glu Glu Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro 
                325                 330                 335     


Thr Asp Glu Pro Val Ala Glu Glu Pro Phe Thr Phe Ala Met Glu Leu 
            340                 345                 350         


Asp Asp Leu Pro Lys Glu Arg Leu Lys Glu Leu Ile Phe Gln Glu Thr 
        355                 360                 365             


Ala Arg Phe Gln Pro Gly Val Leu Glu Ala Pro 
    370                 375                 


<210>  43
<211>  5733
<212>  DNA
<213>  Homo sapiens

<400>  43
agacggacac tgtgccgggg cgagctgaca ggagttcacg gctgcgatag aacatggaga       60

tgtcatgggc gcgacagagc ctggcgggga taccagcagc gtgtgatgag ttccacccgt      120

tcatcgaggc actgctgcct cacgtccgcg ctttctccta cacctggttc aacctgcagg      180

cgcggaagcg caagtacttc aagaagcatg aaaagcggat gtcgaaggac gaggagcggg      240

cggtgaagga cgagctgctg ggcgagaagc ccgagatcaa gcagaagtgg gcatcccggc      300

tgctggccaa gctgcgcaag gacatccggc ccgagttccg cgaggacttc gtgctgacca      360

tcacgggcaa gaagcccccc tgctgcgtgc tctccaaccc cgaccagaag ggcaagatcc      420

ggcggattga ctgcctgcgc caggctgaca aggtgtggcg gctggacctg gtcatggtga      480

ttttgtttaa ggggatcccc ctggaaagta ctgatgggga gcggctctac aagtcgcctc      540

agtgctcgaa ccccggcctg tgcgtccagc cacatcacat tggagtcaca atcaaagaac      600

tggatcttta tctggcttac tttgtccaca ctccggaatc cggacaatca gatagttcaa      660

accagcaagg agatgcggac atcaaaccac tgcccaacgg gcacttaagt ttccaggact      720

gttttgtgac ttccggggtc tggaatgtga cggagctggt gagagtatca cagactcctg      780

ttgcaacagc atcagggccc aacttctccc tggcggacct ggagagtccc agctactaca      840

acatcaacca ggtgaccctg gggcggcggt ccatcacctc ccctccttcc accagcacca      900

ccaagcgccc caagtccatc gatgacagtg agatggagag ccctgttgat gacgtgttct      960

atcccgggac aggccgttcc ccagcagctg gcagcagcca gtccagcggg tggcccaacg     1020

atgtggatgc aggcccggct tctctaaaga agtcaggaaa gctggacttc tgcagtgccc     1080

tctcctctca gggcagctcc ccgcgcatgg ctttcaccca ccacccgctg cctgtgcttg     1140

ctggagtcag accagggagc ccccgggcca cagcatcagc cctgcacttc ccctccacgt     1200

ccatcatcca gcagtcgagc ccgtatttca cgcacccgac catccgctac caccaccacc     1260

acgggcagga ctcactgaag gagtttgtgc agtttgtgtg ctcggatggc tcgggccagg     1320

ccaccggaca gcccaacggt agcggccagg gcaaagtccc ggggtcattt ttgctaccgc     1380

cgccgcctcc agtggccaga cctgtgcccc ttcctatgcc tgattccaaa tccaccagca     1440

ctgccccaga cggcgccgcc ttgactcctc catcaccttc attcgcaacg acaggcgcct     1500

cctctgccaa ccggtttgtc agcatcggac cccgggacgg caactttctg aacatcccac     1560

agcagtctca gtcctggttc ctctgataag atcgacaaaa gaaacaacaa aatgagaaga     1620

agaggttcct cgaaaggggg gagaagaaat tttgagaatg gaaaaatccc ccagcccagc     1680

ccagccccac cgaaaagcaa aaattacacg tcgtcagcca ctcagccctt ctctcctcca     1740

gcccggggac ccccgcgggc cccagaagca gcccagttct cagagagccc ttggaagggg     1800

tctcggtgga gctgtgcacc agcagccaag cagaaagaaa cacgcgacat ggactctgtc     1860

aagtagagga cagaaagcaa gaaaggatgc agaactgcct tcctccccct gaccccgccc     1920

cggccttctg gggaaggaac aaagtcccca aacaaagcaa ccagcacaat tctgaagggg     1980

cctggcctcc accctcaccc cttcctaggg gaaccccacc ctccacacag ccggagctgc     2040

cctagggagc ctggagggcc agcttgtaaa gatgatgggg tttagatccc tcaggctctc     2100

ccctccagac tccgcccttc cctccctccc tccctccctc cctctctgcc aaggctccag     2160

cttcttcccc cagctgctcc cgaccaggag ggggagagca gcctccactt accccacccc     2220

acccttgggc taaaagcccc caggcgggca gggggtgacc cctggagcta gttgcgtgtc     2280

ccagaatgga gggtgttctg acaccccacc ctgagccgca agagcagtcc tggggccctg     2340

gacccctctg tacagtccgt aggaaaaagt cggaatgctc tcgacggcct cgtcccagcc     2400

tgggacaggc cccctttccc ctctctctgc aggccaggag ggcctccttc ctgccacgag     2460

ggaggggagt cgggccccag gtcgcccccg cccccagccc tgcatgcagg tgccctcgct     2520

ccgccccatc agttcctgcc cctgcccctc atgcagactg ccctgctggg gccgggccgg     2580

agggtggagc agaaagggga ccccggagcc gagcgaggag gaccaggcag ccgccgctgc     2640

cgcgctaagc caccacctgc gcttaggtag gcgtcctgct cgccgacttt cagttccttg     2700

ggagggtgtt gggtgtcgtc cttttcaaaa gtgttttgga gctttctgtg ccccccgact     2760

ttcccccgcc tccccgcccc ccacgtggcc acttttctct ggattttagc tgtaatgtct     2820

ttactcttta tttaggggtg gggcattcat tgtttgggtc ttttgctgtt ggaatgggaa     2880

ctcctcctcc atttgagcaa cttgggaaca atttggtaac acaccacagg aagtagctct     2940

cccccccagc cccctcctcc ctcaagggag ggttgggggg cctgtccaga gggtcttcag     3000

aagcccccct gggagggagg ggaggatgag cacgcccagc tcccctccag ggtgtgactt     3060

ggcccctctg gcttgtcttt ctgtgcctta ctcctcctcc tgcgtctccc gttcctggcc     3120

ccttcttgag tccttgtgcc tctctctttc tctctctttc ttaattgtat gaaaacacaa     3180

agcacaggtc aggatcctct gagagaaaat caacattgca ccacgtaggg gtgggctatg     3240

ggctgtattt attgtgaatc tagtttgtga ggctgtggcc ccgagctggc ggagggaggg     3300

aagaggaggg agtgacggga ggggaggagg tcagcgacct ggggccgtag cggcaggcga     3360

acggtgcctg ctacccagct ggaagccaca aggtggctgg ctccaggggc ggcttttgtt     3420

ggaagttgag tgaagccctc cccctgtcct cagcgtgcag ccctagagga ccccagggct     3480

gaggggcagt ggatcctgcg ggagtctccc ggggcgtggg gagtaaggcc ccgggggtgg     3540

ggggccgggt gggccgggcg tgacgcgcgg tcaaagtgca atgatttttc agttcggttg     3600

gctaaacagg gtcagagctg agagcgaagc agaaggggct ccctgtccgg cccacgtgcc     3660

ctttccctcg acgacagtcg agggctcggg ctctgtggga ctgtgggagc tagggtctgc     3720

ggggcgcctg cccgggcgag gtcggaagct gcaggccagc tgggcccggg ccggagcgtg     3780

cccggcgggg ctgcccgggc gggcaggggg tgggggctgc tcctttccca agtggtgttg     3840

tgaggggcaa tgagggcaac aggagatgtg gggacgtgtt aggagagaaa aaaaaaaaaa     3900

caaaaatata tatgggggaa attaactttt ttttttcatt gaaccaagtg caatgcatca     3960

gagagttttc ctatctttgt atgttaagag attaagaaaa aaaaattcta tttttgttgt     4020

aatgtcctcg cggctctggg gacgctaaaa gaaccgggcc tgccccgccc tgcgcgggga     4080

taacgaaagc tgagtgtttt tccctttttt ttgttcgttt ttagtttttt tttttttaag     4140

tcgttttcct gcgttgacga ggatgatctg gggtttttat ttgtttcgtc gttcgttctg     4200

tttcggtggg agggctgaag gaaacgttca cattttagag tttaaaaaaa acacctcgac     4260

atttaaaaaa tcaaccaaca caagatcaaa aaggaaaagg acgagagaaa aattattttt     4320

aagataatta aacataaaac cctggtgctt cttacattat aaagtacgtt ttaaagaacc     4380

cacaaactat tatacataag tttatgaatc aattaaatat cctgcacttg ttaggaatac     4440

gcatatccct tctttgttga gtttaacgga acgggacagc ggcgtgcccc cggcggctgg     4500

actgctccgg ccgcgggtct ccccgggcgc ccctccctgg ggcccagcac ccctcctcgc     4560

cccatccccg tccgggtacg ggggcgcggc aggggtcccc ggcccctccc ccgcagaggt     4620

caatgccaac gaacaaacgt cccctccctc cctccctctc cgccccgagc gcccttcttt     4680

gagccagacg ccaacttgac cctcaccagc attatcagga gcgcgctcag caagttggta     4740

gtttcctccc ccctttcccg gcgcccctcc cgcccccatt caacatctct catcctatcc     4800

ccgaccccct ccggggaaca ccgggaaggc tcgacgctcc aggacaggac cagccacgct     4860

gacaggtcga tttgcccagg cccgcgcccg cacgcacgca cgcacacggc cccgcacaca     4920

gccccgcccc accccgcaac cagccctgtc gactgcctta tacacccgcc cccgcgctgg     4980

ccggccgacc tagtgccttg ttctcacccc cgtgctggcg gagcggacgc cgcgctctgg     5040

gtcccagagg ggccgggtgg ctcagacgac ccaccactcc cccaccctga ccgtgctgaa     5100

cagacccccc cacacgagag aaaataaagg agcaataaag tcacgagaac tttcgtcccc     5160

caatcgagag cccgaggggc accccagccc cgcctctgct cccccccacc ccacccaccc     5220

tcggggcgcc cccctccccc cgcaagccag cctgggccag ccccgcttcg gcccctcccg     5280

ggagatccgt gcgcccgacc agcaccagca tcgcggaccg caaaggccgc ccgtcccgtc     5340

aaacaagttt cttcttaggc taagaaacgc agtatatacg agtatctcta tatatagtac     5400

taatggattt ggtgtgcttc ccccttagcg tccccctccc tctgctcctc ctccttcagc     5460

ctggtctccc cctcttctct gccctccacc cccgtctctg cactgagata cataagaaac     5520

aagggtagtt tactgtctgt tttgttttct gggttttcag tgtcctagcg gaatgcaagt     5580

aggcagccag cccgtctgtt ccctctccgc cccgccccgc cccgcccccg tcactgcgct     5640

tctgttatac catctttgcc tgactctctc cggcttctcc attgaatggc taatgtgtat     5700

gtgaaataaa gaaataaaga aaaacaaacg cga                                  5733


<210>  44
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Met Ser Trp Ala Arg Gln Ser Leu Ala Gly Ile Pro Ala Ala 
1               5                   10                  15      


Cys Asp Glu Phe His Pro Phe Ile Glu Ala Leu Leu Pro His Val Arg 
            20                  25                  30          


Ala Phe Ser Tyr Thr Trp Phe Asn Leu Gln Ala Arg Lys Arg Lys Tyr 
        35                  40                  45              


Phe Lys Lys His Glu Lys Arg Met Ser Lys Asp Glu Glu Arg Ala Val 
    50                  55                  60                  


Lys Asp Glu Leu Leu Gly Glu Lys Pro Glu Ile Lys Gln Lys Trp Ala 
65                  70                  75                  80  


Ser Arg Leu Leu Ala Lys Leu Arg Lys Asp Ile Arg Pro Glu Phe Arg 
                85                  90                  95      


Glu Asp Phe Val Leu Thr Ile Thr Gly Lys Lys Pro Pro Cys Cys Val 
            100                 105                 110         


Leu Ser Asn Pro Asp Gln Lys Gly Lys Ile Arg Arg Ile Asp Cys Leu 
        115                 120                 125             


Arg Gln Ala Asp Lys Val Trp Arg Leu Asp Leu Val Met Val Ile Leu 
    130                 135                 140                 


Phe Lys Gly Ile Pro Leu Glu Ser Thr Asp Gly Glu Arg Leu Tyr Lys 
145                 150                 155                 160 


Ser Pro Gln Cys Ser Asn Pro Gly Leu Cys Val Gln Pro His His Ile 
                165                 170                 175     


Gly Val Thr Ile Lys Glu Leu Asp Leu Tyr Leu Ala Tyr Phe Val His 
            180                 185                 190         


Thr Pro Glu Ser Gly Gln Ser Asp Ser Ser Asn Gln Gln Gly Asp Ala 
        195                 200                 205             


Asp Ile Lys Pro Leu Pro Asn Gly His Leu Ser Phe Gln Asp Cys Phe 
    210                 215                 220                 


Val Thr Ser Gly Val Trp Asn Val Thr Glu Leu Val Arg Val Ser Gln 
225                 230                 235                 240 


Thr Pro Val Ala Thr Ala Ser Gly Pro Asn Phe Ser Leu Ala Asp Leu 
                245                 250                 255     


Glu Ser Pro Ser Tyr Tyr Asn Ile Asn Gln Val Thr Leu Gly Arg Arg 
            260                 265                 270         


Ser Ile Thr Ser Pro Pro Ser Thr Ser Thr Thr Lys Arg Pro Lys Ser 
        275                 280                 285             


Ile Asp Asp Ser Glu Met Glu Ser Pro Val Asp Asp Val Phe Tyr Pro 
    290                 295                 300                 


Gly Thr Gly Arg Ser Pro Ala Ala Gly Ser Ser Gln Ser Ser Gly Trp 
305                 310                 315                 320 


Pro Asn Asp Val Asp Ala Gly Pro Ala Ser Leu Lys Lys Ser Gly Lys 
                325                 330                 335     


Leu Asp Phe Cys Ser Ala Leu Ser Ser Gln Gly Ser Ser Pro Arg Met 
            340                 345                 350         


Ala Phe Thr His His Pro Leu Pro Val Leu Ala Gly Val Arg Pro Gly 
        355                 360                 365             


Ser Pro Arg Ala Thr Ala Ser Ala Leu His Phe Pro Ser Thr Ser Ile 
    370                 375                 380                 


Ile Gln Gln Ser Ser Pro Tyr Phe Thr His Pro Thr Ile Arg Tyr His 
385                 390                 395                 400 


His His His Gly Gln Asp Ser Leu Lys Glu Phe Val Gln Phe Val Cys 
                405                 410                 415     


Ser Asp Gly Ser Gly Gln Ala Thr Gly Gln Pro Asn Gly Ser Gly Gln 
            420                 425                 430         


Gly Lys Val Pro Gly Ser Phe Leu Leu Pro Pro Pro Pro Pro Val Ala 
        435                 440                 445             


Arg Pro Val Pro Leu Pro Met Pro Asp Ser Lys Ser Thr Ser Thr Ala 
    450                 455                 460                 


Pro Asp Gly Ala Ala Leu Thr Pro Pro Ser Pro Ser Phe Ala Thr Thr 
465                 470                 475                 480 


Gly Ala Ser Ser Ala Asn Arg Phe Val Ser Ile Gly Pro Arg Asp Gly 
                485                 490                 495     


Asn Phe Leu Asn Ile Pro Gln Gln Ser Gln Ser Trp Phe Leu 
            500                 505                 510 


<210>  45
<211>  4342
<212>  DNA
<213>  Homo sapiens

<400>  45
agtcttaacc gggtgtgcgg ggagcgcagt ccgggtgcgt aggggccgct cggcgggggc       60

cgcgcgggca agatggtgtg cgctcgggcg gccctcggtc ccggcgcgct ctgggccgcg      120

gcctggggcg tcctgctgct cacagcccct gcgggggcgc agcgtggccg gaagaaggtc      180

gtgcacgtgc tggagggtga gtcgggctcg gtagtggtac agacagcgcc tgggcaggtg      240

gtaagccacc gtggtggcac catcgtcttg ccctgccgct accactatga ggcagccgcc      300

cacggtcacg acggcgtccg gctcaagtgg acaaaggtgg tggacccgct ggccttcacc      360

gacgtcttcg tggcactagg cccccagcac cgggcattcg gcagctaccg tgggcgggct      420

gagctgcagg gcgacgggcc tggggatgcc tccctggtcc tccgcaacgt cacgctgcaa      480

gactacgggc gctatgagtg cgaagtcacc aatgagctgg aagatgacgc tggcatggtc      540

aagctggacc tggaaggcgt ggtctttccc taccaccccc gtggaggccg atacaagctg      600

accttcgcgg aggcgcagcg cgcgtgcgcc gagcaggacg gcatcctggc atctgcagaa      660

cagctgcacg cggcctggcg cgacggcctg gactggtgca acgcgggctg gttgcgcgac      720

ggctcagtgc aataccccgt gaaccggccc cgggagccct gcggcggcct gggggggacc      780

gggagtgcag ggggcggcgg tgatgccaac gggggcctgc gcaactacgg gtatcgccat      840

aacgccgagg aacgctacga cgccttctgc ttcacgtcca acctgccggg gcgcgtgttc      900

ttcctgaagc cgctgcgacc tgtacccttc tccggagctg cgcgcgcgtg tgctgcgcgt      960

ggcgcggccg tggccaaggt ggggcagctg ttcgccgcgt ggaagctgca gctgctagac     1020

cgctgcaccg cgggttggct ggccgatggc agtgcgcgct accccatcgt gaacccgcga     1080

gcgcgctgcg gaggccgcag gcctggtgtg cgcagcctcg gcttcccgga cgccacccga     1140

cggctcttcg gcgtctactg ctaccgcgct ccaggagcac cggacccggc acctggcggc     1200

tggggctggg gctgggcggg cggcggcggc tgggcagggg gcgcgcgcga tcctgctgcc     1260

tggacccctc tgcacgtcta ggctgggagt aggcggacag ccagggcgct tgaccactgg     1320

tctagagccc tgtggtcccc tggagcctgg ccacgccctt gaagccctgg acactggcca     1380

cattccctgt ggtcccttac aaactaactg tgcccctggg gtccctgaag actggctagt     1440

cctggcagaa cagtactttg gagttccctg gagcctggcc agccctcacc tcttctggat     1500

agaggattcc cccaactccc caactttctc catgagggtc acgccccctg aggacctcag     1560

gaggccagca gaacccgcag gctcctgaag actggccacg cctcctgaga ccacttggaa     1620

acagaccaac tgcccccgtg gtcgcctggt ggctggaccc ccgggattga ctagagaccg     1680

gccgtacacc ttctgcatct cactggagac tgaacactag tcccttgcgg tcacgtggga     1740

cactgggcgc ctcctcctcc ccctcctcct cacctggaga gactacagga acttcagggt     1800

cactccccgt ggtcacatgg aggttgtggg ccgaggcgct tattttccct tatggtgacc     1860

tgagtcctgg agactcccat tctccccctc tccctgagag tcccctgcag tttctgggta     1920

acagggcaca cccctctagt ttcatgggcg agcaccccca tctgccacct cagactgaca     1980

cacagccagc tggctcactt actgggggcc acgtcccacc cctcagatat ttctttgaag     2040

ggagagcaaa cccaccctgt cctctgacgt ccctttccca actgtcacca aacagaccat     2100

cttcccaggc ctggggaccg gtaagatcca tgtcactagt tatgcagagc agttgccttg     2160

ggtcccactg tcaccaaggc aaccagtcct gctgctacct gtcacctaga gtcacacacc     2220

ccttccctca tcaggcacac ccatgaagac agtgcctccc tcctccagct gtaaccatgg     2280

ataccacaca tttctcatct cattggcccc caccccagag acctccacct caacttctgg     2340

ctgtccctac cctgactcac cgccatggag atcaccctcc ccgaagctgt cgccagggtg     2400

acccaacatc cagttctccg gctctcacca tggaaacaaa ctgtccctgt ccccaggccc     2460

actccagttc cagaccaccc tccatgctcc acccccaggc ggtttggacc ccaccactgt     2520

tgccatggtg accaaactct ggagtccgag gtaacagaac acctgtcccc ctaggctttt     2580

ccttgtggac aacggggccc tgttcaccaa gctgttgcca tagagactgt caacgttgtc     2640

ctcatgacaa ccagacttcc agttctcagg aacttctcat tgtgggccag aagtcctggg     2700

tgcctcctac tagggctacc ctactgcacc ccatcagggg cctgatggct gccccttccc     2760

cagacagggc tggacttctg gagctgctaa gccaccctcc gtttgcacgt taactctatg     2820

ccggatagca gctgtgcacg agacaatctt gcaacacccg ggcatgtttg tcgtcgtcct     2880

acaaatgagg aaaccgagcc tatggcgtgc cctggtctgt tgagatatgc aagcactgag     2940

ctcctctttt gtcctctgag accccatctc cattctcacc cagttcctct ctccttccct     3000

gacccccacc cacatttccc tccttagaga tccaggaggg atggaatgtt ctttaaaatt     3060

caacacccac caggctctaa gcggcgatct gtgctaagag gtcaggaccc agccgaagtc     3120

ctcggcgttg acaggcagct ggggggacat gatccatgga caaggccatc ccggccgtgg     3180

gagaccccag tcccgaagtc ttgcctgcag gagtactggg gtccccctgg ggccctcttt     3240

actgtcacgt catctctagg aaacctatct ctgagttttg ggaccaggtc ggtttgggtt     3300

tgaattctgc ctcttcttgc tcactgtgtg accaagtgac aaactccttc tgaacctgtg     3360

ttctcccact gtaccagggc tgttctgtgg tccccgtgag tgccaagcat acagtagggg     3420

ctcaataaat ccttgtttct tttgatgaat gagaaaatga ggcagccagt gggtaattcc     3480

tgtataaatg cactttggta gataagatgt tacaagcttg gggggcttgg ggtttttttt     3540

gttttgtttt tttgagatgg agtcctgccc tgtcgcccag gctggagtgc agtcgtgcaa     3600

tcttggctca ctgcaacctc tgcctcccgg gttcaagtga ttctcctgcc tcagcctccc     3660

gagtagctgg gattacaggt gcctgccacc acacccggct aatttttgta tttttagtag     3720

agacagggtt tcaccatgtt ggccaggctg gtcttgaact cctgacctca ggtgatctac     3780

ccacctcggc ctcccaaagt gttggggtta caggtgtgag ccactgcgcc tggccgggct     3840

tgatttttat tctctttgga agtggggtcc ttcattcctc ccccacctcc ccaatctctt     3900

gctcctcttt cttcccccat cctgtgccca ctgtctccct ttagccaccc accatgggtc     3960

tgctccttgt caactctgtc ctgactgggt cattgacaag atccagggca tgaaattcgg     4020

gaaactggaa ggggggttcc tgtaccagga agggagagac attacaaact ttccctgaca     4080

tgaatatgtg ggctgagggc aggggctgag gaagcactgg aagtttctag gatacaacaa     4140

agcatgaaga gaaaaaatag tgtaaggtcc tgaccgtgca cagtggatca tgcctataat     4200

cccagcactt taagagacca aggtgggagg attgcttgag ccagaaggtc gaggctgcag     4260

tgagccatga ttgtaccact gcactccagc ttgggcgacg gagtgagacc ctgtctcaaa     4320

aaataaaaat aagtaaatct cc                                              4342


<210>  46
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Val Cys Ala Arg Ala Ala Leu Gly Pro Gly Ala Leu Trp Ala Ala 
1               5                   10                  15      


Ala Trp Gly Val Leu Leu Leu Thr Ala Pro Ala Gly Ala Gln Arg Gly 
            20                  25                  30          


Arg Lys Lys Val Val His Val Leu Glu Gly Glu Ser Gly Ser Val Val 
        35                  40                  45              


Val Gln Thr Ala Pro Gly Gln Val Val Ser His Arg Gly Gly Thr Ile 
    50                  55                  60                  


Val Leu Pro Cys Arg Tyr His Tyr Glu Ala Ala Ala His Gly His Asp 
65                  70                  75                  80  


Gly Val Arg Leu Lys Trp Thr Lys Val Val Asp Pro Leu Ala Phe Thr 
                85                  90                  95      


Asp Val Phe Val Ala Leu Gly Pro Gln His Arg Ala Phe Gly Ser Tyr 
            100                 105                 110         


Arg Gly Arg Ala Glu Leu Gln Gly Asp Gly Pro Gly Asp Ala Ser Leu 
        115                 120                 125             


Val Leu Arg Asn Val Thr Leu Gln Asp Tyr Gly Arg Tyr Glu Cys Glu 
    130                 135                 140                 


Val Thr Asn Glu Leu Glu Asp Asp Ala Gly Met Val Lys Leu Asp Leu 
145                 150                 155                 160 


Glu Gly Val Val Phe Pro Tyr His Pro Arg Gly Gly Arg Tyr Lys Leu 
                165                 170                 175     


Thr Phe Ala Glu Ala Gln Arg Ala Cys Ala Glu Gln Asp Gly Ile Leu 
            180                 185                 190         


Ala Ser Ala Glu Gln Leu His Ala Ala Trp Arg Asp Gly Leu Asp Trp 
        195                 200                 205             


Cys Asn Ala Gly Trp Leu Arg Asp Gly Ser Val Gln Tyr Pro Val Asn 
    210                 215                 220                 


Arg Pro Arg Glu Pro Cys Gly Gly Leu Gly Gly Thr Gly Ser Ala Gly 
225                 230                 235                 240 


Gly Gly Gly Asp Ala Asn Gly Gly Leu Arg Asn Tyr Gly Tyr Arg His 
                245                 250                 255     


Asn Ala Glu Glu Arg Tyr Asp Ala Phe Cys Phe Thr Ser Asn Leu Pro 
            260                 265                 270         


Gly Arg Val Phe Phe Leu Lys Pro Leu Arg Pro Val Pro Phe Ser Gly 
        275                 280                 285             


Ala Ala Arg Ala Cys Ala Ala Arg Gly Ala Ala Val Ala Lys Val Gly 
    290                 295                 300                 


Gln Leu Phe Ala Ala Trp Lys Leu Gln Leu Leu Asp Arg Cys Thr Ala 
305                 310                 315                 320 


Gly Trp Leu Ala Asp Gly Ser Ala Arg Tyr Pro Ile Val Asn Pro Arg 
                325                 330                 335     


Ala Arg Cys Gly Gly Arg Arg Pro Gly Val Arg Ser Leu Gly Phe Pro 
            340                 345                 350         


Asp Ala Thr Arg Arg Leu Phe Gly Val Tyr Cys Tyr Arg Ala Pro Gly 
        355                 360                 365             


Ala Pro Asp Pro Ala Pro Gly Gly Trp Gly Trp Gly Trp Ala Gly Gly 
    370                 375                 380                 


Gly Gly Trp Ala Gly Gly Ala Arg Asp Pro Ala Ala Trp Thr Pro Leu 
385                 390                 395                 400 


His Val 
        


<210>  47
<211>  1670
<212>  DNA
<213>  Homo sapiens

<400>  47
aatggggacc tggaacctgg gcttactaga gtgccgcgcg tagggctcca ggtcgctggc       60

ttctgcgctt ccttcctctc caaagttgag tatctcctat ctgtgtcctc gtacatactg      120

ccgcctgagg tgccatggcc cccaagccgg gggccgagtg gagcacagcc ctgtcccatc      180

tggtgctggg agtggtgtct ctgcacgcag ccgtgagcac agccgaggca agtcgagggg      240

ctgctgctgg cttcctgctc caggtcttgg ctgccaccac cacgctggcc ccagggctga      300

gcacacacga agactgcctt gctggagcct gggtggccac cgtcatcggc cttccccttc      360

tggccttcga tttccactgg tgtactaatg gtcacttgat gtgcgctggc tgttttatcc      420

acctactagc agatgcccgg ctgaaggagg agcaggccac gtgccccaat tgtcgttgtg      480

agatcagtaa gagcctctgc tgccggaacc tggccgtgga gaaagccgtg agcgagctgc      540

cttcagagtg tggcttctgc ctgcgccagt ttccccgctc cctcctggag aggcaccaga      600

aagaggaatg ccaggacagg gtaacccagt gcaagtacaa acgcatcggc tgcccatggc      660

acggcccctt ccatgagctg acggtgcacg aggctgcgtg cgcccacccg accaagacag      720

gcagtgagct gatggagatc ctggatggga tggaccagag ccaccgcaag gagatgcagc      780

tgtacaacag catcttcagc ctgctcagct tcgagaagat tggctacaca gaggtccagt      840

tccggccgta ccgcacagac gacttcatca cgcgcctgta ctatgagacg cccaggttca      900

cagtgctgaa ccagacgtgg gtcctgaagg ctcgagtcaa cgactcggag cgtaacccca      960

acctgtcctg caagcgtacg ctctccttcc agctcctcct caagagcaag gtcacggcac     1020

cgctggagtg ctccttcctg ctgctcaagg gcccctacga cgacgtgagg atcagccccg     1080

tcatctacca ctttgtcttc accaacgaga gcaacgagac ggactacgtg ccactgccca     1140

tcattgactc cgtggagtgc aacaagctgc tggctgccaa gaacatcaac ctgcggctct     1200

tcctgttcca gatacagaag tagggcgggg cctcaggatg tccgaggagc ccacgggcgg     1260

catcccagca ccgctgccct gtccacctgg ctggcagctg cttcacagga ctatctgatc     1320

actttagcaa aggaggagaa caaacgaagc caacacaggg caagtctgca tgcgtgcgcg     1380

acggggcccc cgcctccggc tcaccccccc gacccctgcc tcccctcctt ccgagggccg     1440

ccagaggctg ggctgacccg aagaggagac ggtgcaccag gcgccccgag gctcagagac     1500

ggtggcagca aggaggccga gaggcacagc gaccctgccc cagcccttct gtgcagtcag     1560

gcggcggtgc tgctccatcc ctgcgggttc cggcggggcg cgggggcctt gctgacatca     1620

gacgggatat ccgaatatct gatagcaatt aaaaggcagc cttgtttcgt                1670


<210>  48
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Pro Lys Pro Gly Ala Glu Trp Ser Thr Ala Leu Ser His Leu 
1               5                   10                  15      


Val Leu Gly Val Val Ser Leu His Ala Ala Val Ser Thr Ala Glu Ala 
            20                  25                  30          


Ser Arg Gly Ala Ala Ala Gly Phe Leu Leu Gln Val Leu Ala Ala Thr 
        35                  40                  45              


Thr Thr Leu Ala Pro Gly Leu Ser Thr His Glu Asp Cys Leu Ala Gly 
    50                  55                  60                  


Ala Trp Val Ala Thr Val Ile Gly Leu Pro Leu Leu Ala Phe Asp Phe 
65                  70                  75                  80  


His Trp Cys Thr Asn Gly His Leu Met Cys Ala Gly Cys Phe Ile His 
                85                  90                  95      


Leu Leu Ala Asp Ala Arg Leu Lys Glu Glu Gln Ala Thr Cys Pro Asn 
            100                 105                 110         


Cys Arg Cys Glu Ile Ser Lys Ser Leu Cys Cys Arg Asn Leu Ala Val 
        115                 120                 125             


Glu Lys Ala Val Ser Glu Leu Pro Ser Glu Cys Gly Phe Cys Leu Arg 
    130                 135                 140                 


Gln Phe Pro Arg Ser Leu Leu Glu Arg His Gln Lys Glu Glu Cys Gln 
145                 150                 155                 160 


Asp Arg Val Thr Gln Cys Lys Tyr Lys Arg Ile Gly Cys Pro Trp His 
                165                 170                 175     


Gly Pro Phe His Glu Leu Thr Val His Glu Ala Ala Cys Ala His Pro 
            180                 185                 190         


Thr Lys Thr Gly Ser Glu Leu Met Glu Ile Leu Asp Gly Met Asp Gln 
        195                 200                 205             


Ser His Arg Lys Glu Met Gln Leu Tyr Asn Ser Ile Phe Ser Leu Leu 
    210                 215                 220                 


Ser Phe Glu Lys Ile Gly Tyr Thr Glu Val Gln Phe Arg Pro Tyr Arg 
225                 230                 235                 240 


Thr Asp Asp Phe Ile Thr Arg Leu Tyr Tyr Glu Thr Pro Arg Phe Thr 
                245                 250                 255     


Val Leu Asn Gln Thr Trp Val Leu Lys Ala Arg Val Asn Asp Ser Glu 
            260                 265                 270         


Arg Asn Pro Asn Leu Ser Cys Lys Arg Thr Leu Ser Phe Gln Leu Leu 
        275                 280                 285             


Leu Lys Ser Lys Val Thr Ala Pro Leu Glu Cys Ser Phe Leu Leu Leu 
    290                 295                 300                 


Lys Gly Pro Tyr Asp Asp Val Arg Ile Ser Pro Val Ile Tyr His Phe 
305                 310                 315                 320 


Val Phe Thr Asn Glu Ser Asn Glu Thr Asp Tyr Val Pro Leu Pro Ile 
                325                 330                 335     


Ile Asp Ser Val Glu Cys Asn Lys Leu Leu Ala Ala Lys Asn Ile Asn 
            340                 345                 350         


Leu Arg Leu Phe Leu Phe Gln Ile Gln Lys 
        355                 360         


<210>  49
<211>  3145
<212>  DNA
<213>  Homo sapiens

<400>  49
gagactgaaa ggaaccataa tttgtgacat cagttgtttt ctttgataag cagctattta       60

tgattctgga agattaaggc agataggaaa ccccatctga gattttaata aatccctcaa      120

acaataaacc acatcatgga catacagctg gaccctgcca gagatgacct gcctctcatg      180

gccaacacca gccacatact tgtgaagcac tatgtactgg atttggatgt ggattttgaa      240

agtcaagtca ttgaggggac catagtgctt ttcctcgagg atggaaacag attcaagaaa      300

cagaatagct ctattgagga agcctgccaa tcagaatcaa acaaagcctg caaatttggg      360

atgcctgaac cctgccatat tcccgtgaca aatgcaagga ccttctcatc tgaaatggaa      420

tataatgatt ttgcaatctg tagtaaaggt gaaaaagata cttctgataa agatggtaac      480

catgacaacc aggaacatgc ttctgggatt tctagctcaa agtactgctg tgacacaggg      540

aatcatggga gtgaggattt tttgctagtg ttggactgct gtgatttatc tgtgttaaaa      600

gtcgaggagg tggatgttgc tgctgtgcca ggtctggaaa aatttacaag gtctcctgag      660

ctcacggttg tttctgagga gttcaggaat cagattgtac gtgaacttgt gactttgcct      720

gcaaatcgtt ggagggagca gttagactat tacgctcgct gcagccaggc tcctggctgt      780

ggggaactcc tctttgacac tgacacttgg agcttgcaga taaggaagac aggggctcag      840

acagctactg actttcctca tgctatcagg atatggtaca aaactaaacc tgaagggcga      900

tcggttacat ggacctcaga ccagagtggc aggccatgtg tttatactgt gggatctccc      960

ataaacaaca gggccctttt tccatgccag gagccacccg ttgccatgtc aacatggcag     1020

gctacagttc gagcagctgc atcttttgtt gttttaatga gtggggaaaa ttctgccaaa     1080

ccaacgcagc tttgggaaga gtgctcaagc tggtattact atgtaactat gccaatgcca     1140

gcctccacct tcacaattgc agtgggatgc tggacagaaa tgaagatgga gacatggtca     1200

tcaaatgatt tggcaacaga gagacccttc tcaccttctg aggccaactt caggcatgtt     1260

ggtgtttgca gtcacatgga atacccctgc cgcttccaga atgcttctgc caccacccag     1320

gagatcattc ctcatcgggt ctttgcccct gtgtgcctca cgggtgcctg ccaagagacc     1380

cttctgcggc tgatccctcc ttgcctctca gcagcacatt ctgttctggg agcacacccg     1440

ttctctcggc tggatgttct catcgtccct gccaactttc caagtctggg gatggccagc     1500

ccacacatca tgttcctctc tcagagcatc ttgacaggag ggaaccatct ctgtgggacc     1560

cgcctctgcc atgaaattgc ccatgcctgg tttggcctag ccatcggggc ccgagactgg     1620

acggaggagt ggctgagtga aggcttcgcc actcacttgg aggatgtgtt ttgggccaca     1680

gcacagcagc tggcccccta tgaggcccgg gagcagcagg agctgagggc ttgtctgcgc     1740

tggcgtcgcc tccaggacga gatgcaatgc tcccccgagg agatgcaggt gttaagaccc     1800

agtaaagaca aaactggcca cacaagtgac tcgggagcat ctgttatcaa gcatggactt     1860

aatccggaga agatcttcat gcaggtgcat tatttaaagg gctacttcct tcttcggttt     1920

cttgccaaaa gacttggaga tgaaacctat ttttcatttt taagaaaatt tgtgcacaca     1980

tttcatggac agctgattct ttcccaggat ttccttcaaa tgctactgga gaacattcca     2040

gaagaaaaaa ggcttgagct gtctgttgaa aacatctacc aagactggct tgagagttcc     2100

ggaataccaa agccgctgca gagggagcgt cgcgccgggg cggagtgcgg gcttgcgcgg     2160

caagtgcgcg ccgaggtcac gaaatggatt ggagtgaacc ggagaccccg aaaacggaag     2220

cgcagggaga aggaagaggt gtttgaaaag cttcttccag accagctggt cttgcttctg     2280

gagcatctct tggagcagaa gactctgagc ccccgaactc tgcaaagcct ccagaggaca     2340

taccacctcc aggatcagga tgcagaggtt cgccatcggt ggtgtgaact cattgttaag     2400

cacaagttca cgaaagccta caaaagtgtg gagaggttcc ttcaggagga tcaggccatg     2460

ggtgtgtacc tctacgggga gctgatggtg agtgaggacg ccagacagca gcagctcgcc     2520

cgtaggtgct tcgagcggac caaggagcag atggataggt cctcagccca ggtggtggcc     2580

gaaatgttat tttaacgagg aaagaccaca gcaagattct ttcattcgtc tcctcctagc     2640

ctgggggacc aggctcgaac tgaccctgga catcaaagga gggattatgt ggctgctaaa     2700

gccatcggcc cacagccctg ttcacatctt ggtgcttctc tttcccagag gctggtccca     2760

gccaggcaca cacaaaaggc agattctcgt aaacgcagcc tccctccctg gaggctgcct     2820

cctgccctgg atctggagtg gagctgctct gagattttga gttcttctgc agagatgatt     2880

aaatatatcc aagagacatt ggaaaacctg ctgaacattt tacattggtc tgctcagcac     2940

atggctggat gcggatattt ctataattcc agaaagtcac acagctcctc tgtatgagac     3000

cagtgggcgc catttaaaag aacaggatga gaatctaaga tatattatta ataaatgtaa     3060

tggatttttt ttttgtatac gtgtttgctt ctaaatttca tactgtttaa aaataataaa     3120

ggccaggtgc ggtggcaaaa aaaaa                                           3145


<210>  50
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asp Ile Gln Leu Asp Pro Ala Arg Asp Asp Leu Pro Leu Met Ala 
1               5                   10                  15      


Asn Thr Ser His Ile Leu Val Lys His Tyr Val Leu Asp Leu Asp Val 
            20                  25                  30          


Asp Phe Glu Ser Gln Val Ile Glu Gly Thr Ile Val Leu Phe Leu Glu 
        35                  40                  45              


Asp Gly Asn Arg Phe Lys Lys Gln Asn Ser Ser Ile Glu Glu Ala Cys 
    50                  55                  60                  


Gln Ser Glu Ser Asn Lys Ala Cys Lys Phe Gly Met Pro Glu Pro Cys 
65                  70                  75                  80  


His Ile Pro Val Thr Asn Ala Arg Thr Phe Ser Ser Glu Met Glu Tyr 
                85                  90                  95      


Asn Asp Phe Ala Ile Cys Ser Lys Gly Glu Lys Asp Thr Ser Asp Lys 
            100                 105                 110         


Asp Gly Asn His Asp Asn Gln Glu His Ala Ser Gly Ile Ser Ser Ser 
        115                 120                 125             


Lys Tyr Cys Cys Asp Thr Gly Asn His Gly Ser Glu Asp Phe Leu Leu 
    130                 135                 140                 


Val Leu Asp Cys Cys Asp Leu Ser Val Leu Lys Val Glu Glu Val Asp 
145                 150                 155                 160 


Val Ala Ala Val Pro Gly Leu Glu Lys Phe Thr Arg Ser Pro Glu Leu 
                165                 170                 175     


Thr Val Val Ser Glu Glu Phe Arg Asn Gln Ile Val Arg Glu Leu Val 
            180                 185                 190         


Thr Leu Pro Ala Asn Arg Trp Arg Glu Gln Leu Asp Tyr Tyr Ala Arg 
        195                 200                 205             


Cys Ser Gln Ala Pro Gly Cys Gly Glu Leu Leu Phe Asp Thr Asp Thr 
    210                 215                 220                 


Trp Ser Leu Gln Ile Arg Lys Thr Gly Ala Gln Thr Ala Thr Asp Phe 
225                 230                 235                 240 


Pro His Ala Ile Arg Ile Trp Tyr Lys Thr Lys Pro Glu Gly Arg Ser 
                245                 250                 255     


Val Thr Trp Thr Ser Asp Gln Ser Gly Arg Pro Cys Val Tyr Thr Val 
            260                 265                 270         


Gly Ser Pro Ile Asn Asn Arg Ala Leu Phe Pro Cys Gln Glu Pro Pro 
        275                 280                 285             


Val Ala Met Ser Thr Trp Gln Ala Thr Val Arg Ala Ala Ala Ser Phe 
    290                 295                 300                 


Val Val Leu Met Ser Gly Glu Asn Ser Ala Lys Pro Thr Gln Leu Trp 
305                 310                 315                 320 


Glu Glu Cys Ser Ser Trp Tyr Tyr Tyr Val Thr Met Pro Met Pro Ala 
                325                 330                 335     


Ser Thr Phe Thr Ile Ala Val Gly Cys Trp Thr Glu Met Lys Met Glu 
            340                 345                 350         


Thr Trp Ser Ser Asn Asp Leu Ala Thr Glu Arg Pro Phe Ser Pro Ser 
        355                 360                 365             


Glu Ala Asn Phe Arg His Val Gly Val Cys Ser His Met Glu Tyr Pro 
    370                 375                 380                 


Cys Arg Phe Gln Asn Ala Ser Ala Thr Thr Gln Glu Ile Ile Pro His 
385                 390                 395                 400 


Arg Val Phe Ala Pro Val Cys Leu Thr Gly Ala Cys Gln Glu Thr Leu 
                405                 410                 415     


Leu Arg Leu Ile Pro Pro Cys Leu Ser Ala Ala His Ser Val Leu Gly 
            420                 425                 430         


Ala His Pro Phe Ser Arg Leu Asp Val Leu Ile Val Pro Ala Asn Phe 
        435                 440                 445             


Pro Ser Leu Gly Met Ala Ser Pro His Ile Met Phe Leu Ser Gln Ser 
    450                 455                 460                 


Ile Leu Thr Gly Gly Asn His Leu Cys Gly Thr Arg Leu Cys His Glu 
465                 470                 475                 480 


Ile Ala His Ala Trp Phe Gly Leu Ala Ile Gly Ala Arg Asp Trp Thr 
                485                 490                 495     


Glu Glu Trp Leu Ser Glu Gly Phe Ala Thr His Leu Glu Asp Val Phe 
            500                 505                 510         


Trp Ala Thr Ala Gln Gln Leu Ala Pro Tyr Glu Ala Arg Glu Gln Gln 
        515                 520                 525             


Glu Leu Arg Ala Cys Leu Arg Trp Arg Arg Leu Gln Asp Glu Met Gln 
    530                 535                 540                 


Cys Ser Pro Glu Glu Met Gln Val Leu Arg Pro Ser Lys Asp Lys Thr 
545                 550                 555                 560 


Gly His Thr Ser Asp Ser Gly Ala Ser Val Ile Lys His Gly Leu Asn 
                565                 570                 575     


Pro Glu Lys Ile Phe Met Gln Val His Tyr Leu Lys Gly Tyr Phe Leu 
            580                 585                 590         


Leu Arg Phe Leu Ala Lys Arg Leu Gly Asp Glu Thr Tyr Phe Ser Phe 
        595                 600                 605             


Leu Arg Lys Phe Val His Thr Phe His Gly Gln Leu Ile Leu Ser Gln 
    610                 615                 620                 


Asp Phe Leu Gln Met Leu Leu Glu Asn Ile Pro Glu Glu Lys Arg Leu 
625                 630                 635                 640 


Glu Leu Ser Val Glu Asn Ile Tyr Gln Asp Trp Leu Glu Ser Ser Gly 
                645                 650                 655     


Ile Pro Lys Pro Leu Gln Arg Glu Arg Arg Ala Gly Ala Glu Cys Gly 
            660                 665                 670         


Leu Ala Arg Gln Val Arg Ala Glu Val Thr Lys Trp Ile Gly Val Asn 
        675                 680                 685             


Arg Arg Pro Arg Lys Arg Lys Arg Arg Glu Lys Glu Glu Val Phe Glu 
    690                 695                 700                 


Lys Leu Leu Pro Asp Gln Leu Val Leu Leu Leu Glu His Leu Leu Glu 
705                 710                 715                 720 


Gln Lys Thr Leu Ser Pro Arg Thr Leu Gln Ser Leu Gln Arg Thr Tyr 
                725                 730                 735     


His Leu Gln Asp Gln Asp Ala Glu Val Arg His Arg Trp Cys Glu Leu 
            740                 745                 750         


Ile Val Lys His Lys Phe Thr Lys Ala Tyr Lys Ser Val Glu Arg Phe 
        755                 760                 765             


Leu Gln Glu Asp Gln Ala Met Gly Val Tyr Leu Tyr Gly Glu Leu Met 
    770                 775                 780                 


Val Ser Glu Asp Ala Arg Gln Gln Gln Leu Ala Arg Arg Cys Phe Glu 
785                 790                 795                 800 


Arg Thr Lys Glu Gln Met Asp Arg Ser Ser Ala Gln Val Val Ala Glu 
                805                 810                 815     


Met Leu Phe 
            


<210>  51
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  51
agcagtggta tcaacgcaga gtactttttt tttttttttt tttttttttt tttt             54


<210>  52
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  52
aagcagtggt atcaacgcag agtacggg                                          28


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic

<400>  53
aagcagtggt atcaacgcag agt                                               23


