﻿                         Sequence Listing

<110>  Biotheus Inc.

<120>  ANTI-PD-L1 SINGLE-DOMAIN ANTIBODY AND DERIVATIVES AND USE THEREOF

<130>  401575

<150>  CN201910863109.0

<151>  2019-09-12

<160>  111

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  1
Gly Phe Thr Phe Ser Ser Tyr Trp Met Tyr 
1               5                   10  

<210>  2
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  2
Ser Ile Asn Ser Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<400>  3
Ala Lys Asp Pro Gly Gly Tyr Ala 
1               5               

<210>  4
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  4
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Ser Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  5
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  5
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attaatagta gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  6
<211>  11
<212>  PRT
<213>  artificial sequence

<400>  6
Ser Gly Phe Thr Phe Ser Ser Tyr Trp Met Tyr 
1               5                   10      

<210>  7
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  7
Ser Ile Asn Thr Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  8
<211>  8
<212>  PRT
<213>  artificial sequence

<400>  8
Ala Lys Asp Pro Gly Gly Tyr Ala 
1               5               

<210>  9
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  9
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Thr Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  10
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  10
caggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attaatacta gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  11
<211>  13
<212>  PRT
<213>  artificial sequence

<400>  11
Gly Arg Thr Phe Asn Asn Ser Ala Met Gly Ala Met Gly 
1               5                   10              

<210>  12
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  12
Thr Ile Thr Trp Ser Ser Gly Ser Ser Phe Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  13
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  13
Ala Ser Arg Lys Leu Gly Gly Val Val Thr Val Val Thr Ser Tyr Asp 
1               5                   10                  15      
Phe 
    

<210>  14
<211>  127
<212>  PRT
<213>  artificial sequence

<400>  14
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Ser 
            20                  25                  30          
Ala Met Gly Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              
Glu Phe Val Ala Thr Ile Thr Trp Ser Ser Gly Ser Ser Phe Tyr Ala 
    50                  55                  60                  
Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Ser Arg Lys Leu Gly Gly Val Val Thr Val Val Thr 
            100                 105                 110         
Ser Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         

<210>  15
<211>  381
<212>  DNA
<213>  artificial sequence

<400>  15
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgcag cctctggacg caccttcaat aactcggcca tgggcgccat gggatggttc       120
cgccaggcgc cagggaaaga gcgtgagttt gtcgcgacaa ttacctggag tagtggtagc       180
tcattttatg caaactccgt gaagggccga ttcaccatct ccagagacaa cgccaagaac       240
acggtgtatc tgcaaatgaa cagcctgaaa cctgaggaca cggccgttta ttactgtgca       300
tcacgcaaat tgggaggggt tgtaacggta gttacttcgt atgacttctg gggccagggg       360
acccaggtca ccgtctccag t                                                 381

<210>  16
<211>  13
<212>  PRT
<213>  artificial sequence

<400>  16
Gly Arg Thr Phe Asp Asn Tyr Ala Met Gly Ala Met Gly 
1               5                   10              

<210>  17
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  17
Thr Ile Thr Trp Ser Ser Gly Ser Ser Phe Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  18
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  18
Ala Ser Arg Lys Leu Gly Gly Val Val Thr Val Val Thr Ser Tyr Asp 
1               5                   10                  15      
Phe 
    

<210>  19
<211>  127
<212>  PRT
<213>  artificial sequence

<400>  19
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asp Asn Tyr 
            20                  25                  30          
Ala Met Gly Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              
Glu Phe Val Ala Thr Ile Thr Trp Ser Ser Gly Ser Ser Phe Tyr Ala 
    50                  55                  60                  
Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Ser Arg Lys Leu Gly Gly Val Val Thr Val Val Thr 
            100                 105                 110         
Ser Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         

<210>  20
<211>  381
<212>  DNA
<213>  artificial sequence

<400>  20
caggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgagactc        60
tcctgtgcag cctctggacg caccttcgat aactatgcca tgggcgccat gggatggttc       120
cgccaggcgc cagggaaaga gcgtgagttt gtcgcgacaa ttacctggag tagtggtagc       180
tcattttatg caaactccgt gaagggccga ttcaccatct ccagagacaa cgccaagaac       240
acggtgtatc tgcaaatgaa cagcctgaaa cctgacgaca cggccgttta ttactgtgca       300
tcacgcaaat tgggaggggt tgtaacggta gttacttcgt atgacttctg gggccagggg       360
acccaggtca ccgtctccag t                                                 381

<210>  21
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  21
Gly Arg Thr Phe Ser Thr Tyr Ala Val Gly 
1               5                   10  

<210>  22
<211>  18
<212>  PRT
<213>  artificial sequence

<400>  22
Gly Arg Leu Thr Trp Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      
Lys Gly 
        

<210>  23
<211>  20
<212>  PRT
<213>  artificial sequence

<400>  23
Ala Ala Asp Tyr Arg Ser Asn Ser Thr Trp Ser Leu Gln Ser Pro Ala 
1               5                   10                  15      
Arg Tyr Glu Asn 
            20  

<210>  24
<211>  127
<212>  PRT
<213>  artificial sequence

<400>  24
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Gly Leu Ser Cys Thr Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Phe Val 
        35                  40                  45              
Gly Arg Leu Thr Trp Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Tyr Arg Ser Asn Ser Thr Trp Ser Leu Gln Ser Pro Ala 
            100                 105                 110         
Arg Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         

<210>  25
<211>  381
<212>  DNA
<213>  artificial sequence

<400>  25
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctggggactc tctgggactc        60
tcctgtacag cctctggacg caccttcagt acctatgccg tggggtggtt ccgccaggct       120
ccagggaagg ggcgtgaatt tgtaggacgt cttacatgga gcgggagtag aacatactat       180
gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat       240
ctgcaaatga acagcctgag acctgaggac acggccgttt attactgtgc agccgactac       300
cgaagtaaca gtacctggtc cctgcaaagc ccggcacgtt atgaaaattg gggccagggg       360
acccaggtca ccgtctccag t                                                 381

<210>  26
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  26
Gly Arg Thr Val Ser Asn Tyr Ala Met Gly 
1               5                   10  

<210>  27
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  27
Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  28
<211>  19
<212>  PRT
<213>  artificial sequence

<400>  28
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Glu 
1               5                   10                  15      
Tyr Glu Asn 
            

<210>  29
<211>  126
<212>  PRT
<213>  artificial sequence

<400>  29
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Val Ser Asn Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Leu Ser Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Glu 
            100                 105                 110         
Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  30
<211>  378
<212>  DNA
<213>  artificial sequence

<400>  30
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgtag cctctggacg caccgtcagt aactatgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tgtagcacgg attaccggga gtggtagtag cacattctat       180
gcagactccg tgaagggccg attcaccatc tccagaaaca acttgtcgaa cacggtgtat       240
ctgcagatga acagcctgaa acgtgaggac acggccgttt attactgtgc agcagatcgc       300
tggcgttcaa tggtgactag atctgacccg agggagtatg agaactgggg ccaggggacc       360
caggtcaccg tctccagt                                                     378

<210>  31
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  31
Gly Arg Thr Val Ser Asn Tyr Ala Met Gly 
1               5                   10  

<210>  32
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  32
Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  33
<211>  19
<212>  PRT
<213>  artificial sequence

<400>  33
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Glu 
1               5                   10                  15      
Tyr Glu Asn 
            

<210>  34
<211>  126
<212>  PRT
<213>  artificial sequence

<400>  34
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Val Ser Asn Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Leu Phe Thr Ile Ser Arg Asn Asn Leu Ser Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Glu 
            100                 105                 110         
Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  35
<211>  378
<212>  DNA
<213>  artificial sequence

<400>  35
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgtag cctctggacg caccgtcagt aactatgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tgtagcacgg attaccggga gtggtagtag cacattctat       180
gcagactccg tgaagggcct attcaccatc tccagaaaca acttgtcgaa cacggtgtat       240
ctgcagatga acagcctgaa acgtgaggac acggccgttt attactgtgc agcagatcgc       300
tggcgttcaa tggtgactag atctgacccg agggagtatg agaactgggg ccaggggacc       360
caggtcaccg tctccagt                                                     378

<210>  36
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  36
Gly Arg Thr Val Ser Asn Tyr Ala Met Gly 
1               5                   10  

<210>  37
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  37
Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  38
<211>  19
<212>  PRT
<213>  artificial sequence

<400>  38
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Tyr Pro Arg Glu 
1               5                   10                  15      
Tyr Glu Asn 
            

<210>  39
<211>  126
<212>  PRT
<213>  artificial sequence

<400>  39
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Val Ser Asn Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Tyr Pro Arg Glu 
            100                 105                 110         
Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  40
<211>  378
<212>  DNA
<213>  artificial sequence

<400>  40
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgtag cctctggacg caccgtcagt aactatgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tgtagcacgg attaccggga gtggtagtag cacattctat       180
gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cgcggtgtat       240
ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcagatcgc       300
tggcgttcaa tggtgactag atcttacccg agggagtatg agaactgggg ccaggggacc       360
caggtcaccg tctccagt                                                     378

<210>  41
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  41
Gly Arg Thr Val Ser Asn Tyr Ala Met Gly 
1               5                   10  

<210>  42
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  42
Arg Ile Thr Gly Ser Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  43
<211>  19
<212>  PRT
<213>  artificial sequence

<400>  43
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Glu 
1               5                   10                  15      
Tyr Glu Asn 
            

<210>  44
<211>  126
<212>  PRT
<213>  artificial sequence

<400>  44
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Ala Gly Asp 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Val Ser Asn Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Arg Ile Thr Gly Ser Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Leu Ser Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Glu 
            100                 105                 110         
Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  45
<211>  378
<212>  DNA
<213>  artificial sequence

<400>  45
caggtgcagc tgcaggagtc tggaggaggt gtggtgcagg ctggggactc tctgagactc        60
tcctgtgtag cctctggacg caccgtcagt aactatgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tgtagcacgg attaccggga gtggtcgtac cacatactat       180
gcagactccg tgaagggccg attcaccatc tccagaaaca acttgtcgaa cacggtgtat       240
ctgcagatga acagcctgaa acgtgaggac acggccgttt attactgtgc agcagatcgc       300
tggcgttcaa tggtgactag atctgacccg agggagtatg agaactgggg ccaggggacc       360
caggtcaccg tctccagt                                                     378

<210>  46
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  46
Gly Arg Thr Val Ser Asn Tyr Ala Met Gly 
1               5                   10  

<210>  47
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  47
Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  48
<211>  19
<212>  PRT
<213>  artificial sequence

<400>  48
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Asp 
1               5                   10                  15      
Tyr Glu Asn 
            

<210>  49
<211>  126
<212>  PRT
<213>  artificial sequence

<400>  49
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Arg Thr Val Ser Asn Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Arg Ile Thr Gly Ser Gly Ser Ser Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn Leu Ser Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Arg Trp Arg Ser Met Val Thr Arg Ser Asp Pro Arg Asp 
            100                 105                 110         
Tyr Glu Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210>  50
<211>  378
<212>  DNA
<213>  artificial sequence

<400>  50
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgtag cctctggacg caccgtcagt aactatgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tgtagcacgg attaccggga gtggtagtag cacattctat       180
gcagactccg tgaagggccg attcaccatc tccagaaaca acttgtcgaa cacggtgtat       240
ctgcagatga acagcctgaa acgtgaggac acggccgttt attactgtgc agcagatcgc       300
tggcgttcaa tggtgactag atctgacccg agggattatg agaactgggg ccaggggacc       360
caggtcaccg tctccagt                                                     378

<210>  51
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  51
Gly Arg Thr Phe Ser Arg Tyr Ala Val Gly 
1               5                   10  

<210>  52
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  52
Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  53
<211>  15
<212>  PRT
<213>  artificial sequence

<400>  53
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr 
1               5                   10                  15  

<210>  54
<211>  122
<212>  PRT
<213>  artificial sequence

<400>  54
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Leu Gly Arg Asp Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  55
<211>  366
<212>  DNA
<213>  artificial sequence

<400>  55
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgcag cctctggacg caccttcagt aggtatgccg tgggctggtt ccgccaggct       120
ccagggctgg ggcgtgactt tgtagcagct attacctgga gtggtggtta cacatactat       180
gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat       240
ttgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtcgatacg       300
aggaatgtaa tcggcccaag agcgggagac tactggggcc aggggaccca ggtcaccgtc       360
tccagt                                                                  366

<210>  56
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  56
Gly Ser Thr Phe Ser Arg Tyr Ala Val Gly 
1               5                   10  

<210>  57
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  57
Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  58
<211>  15
<212>  PRT
<213>  artificial sequence

<400>  58
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr 
1               5                   10                  15  

<210>  59
<211>  122
<212>  PRT
<213>  artificial sequence

<400>  59
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Leu Gly Arg Asp Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  60
<211>  366
<212>  DNA
<213>  artificial sequence

<400>  60
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgcag cctctggaag caccttcagt aggtatgccg tgggctggtt ccgccaggct       120
ccagggctgg ggcgtgactt tgtagcagct attacctgga gtggtggtta cacatactat       180
gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat       240
ttgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtcgatacg       300
aggaatgtaa tcggcccaag agcgggagac tactggggcc aggggaccca ggtcaccgtc       360
tccagt                                                                  366

<210>  61
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  61
Gly Arg Thr Phe Ser Arg Tyr Ala Val Gly 
1               5                   10  

<210>  62
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  62
Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  63
<211>  15
<212>  PRT
<213>  artificial sequence

<400>  63
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr 
1               5                   10                  15  

<210>  64
<211>  122
<212>  PRT
<213>  artificial sequence

<400>  64
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Tyr 
            20                  25                  30          
Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Leu Gly Arg Asp Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Asn Val Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  65
<211>  366
<212>  DNA
<213>  artificial sequence

<400>  65
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgcag cctctggacg caccttcagt aggtatgccg tgggctggtt ccgccaggct       120
ccagggctgg ggcgtgactt tgtagcagct attacctgga gtggtggtta cacatactat       180
gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgatctat       240
ctccaaatga acagcctgaa cgttgaggac acgggcgttt attactgcgc agtcgatacg       300
aggaatgtaa tcggcccaag agcgggagac tactggggcc aggggaccca ggtcaccgtc       360
tccagt                                                                  366

<210>  66
<211>  13
<212>  PRT
<213>  artificial sequence

<400>  66
Ala Ala Ser Gly Arg Thr Phe Ser Arg Phe Ala Met Gly 
1               5                   10              

<210>  67
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  67
Ala Ile Ser Trp Ser Gly Gly Met Ile Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  68
<211>  15
<212>  PRT
<213>  artificial sequence

<400>  68
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr 
1               5                   10                  15  

<210>  69
<211>  122
<212>  PRT
<213>  artificial sequence

<400>  69
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Arg Phe 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Trp Ser Gly Gly Met Ile Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  70
<211>  366
<212>  DNA
<213>  artificial sequence

<400>  70
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgcag cctctggacg cactttcagt aggtttgcca tgggctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tgtagccgct attagctgga gtggtggtat gatatactat       180
acagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa catgctgtat       240
ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agtcgatacg       300
aggaatgtaa tcggcccaag agcgggagac tactggggcc aggggaccca ggtcaccgtc       360
tccagt                                                                  366

<210>  71
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  71
Gly Arg Ala Phe Ser Val Tyr Pro Met Ala 
1               5                   10  

<210>  72
<211>  16
<212>  PRT
<213>  artificial sequence

<400>  72
Arg Leu Thr Tyr Thr Ser Asn Thr Phe Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      

<210>  73
<211>  19
<212>  PRT
<213>  artificial sequence

<400>  73
Ala Val Glu Asn Arg Ser Ser Ser Trp Ser Leu Gln Ser Pro Ala Arg 
1               5                   10                  15      
Tyr Asp Asp 
            

<210>  74
<211>  125
<212>  PRT
<213>  artificial sequence

<400>  74
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Arg Ala Phe Ser Val Tyr 
            20                  25                  30          
Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ile 
        35                  40                  45              
Ala Arg Leu Thr Tyr Thr Ser Asn Thr Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Val Glu Asn Arg Ser Ser Ser Trp Ser Leu Gln Ser Pro Ala Arg Tyr 
            100                 105                 110         
Asp Asp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210>  75
<211>  375
<212>  DNA
<213>  artificial sequence

<400>  75
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc        60
tcatgtacag cctctggacg cgccttcagt gtctacccca tggcctggtt ccgccaggct       120
ccagggaagg agcgtgagtt tatagcacgt cttacgtata ctagtaacac attctatgca       180
gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggtgtatctg       240
cagatgaaca gcctgaaacc tgaggacacg gccgtttatt actgtgcggt cgagaaccgc       300
agtagtagtt ggtccctgca aagcccggca cgttatgatg actggggcca ggggacccag       360
gtcaccgtct ccagt                                                        375

<210>  76
<211>  10
<212>  PRT
<213>  artificial sequence

<400>  76
Gly Arg Thr Gly Ser Arg Tyr Ala Val Gly 
1               5                   10  

<210>  77
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  77
Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  78
<211>  15
<212>  PRT
<213>  artificial sequence

<400>  78
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr 
1               5                   10                  15  

<210>  79
<211>  122
<212>  PRT
<213>  artificial sequence

<400>  79
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Gly Ser Arg Tyr 
            20                  25                  30          
Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Leu Gly Arg Asp Phe Val 
        35                  40                  45              
Ala Ala Ile Thr Trp Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Val Asp Thr Arg Asn Val Ile Gly Pro Arg Ala Gly Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210>  80
<211>  366
<212>  DNA
<213>  artificial sequence

<400>  80
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagactc        60
tcctgtgcag cctctggacg caccggcagt aggtatgccg tgggctggtt ccgccaggct       120
ccagggctgg ggcgtgactt tgtagcagct attacctgga gtggtggtta cacatactat       180
gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgatgtat       240
ctgcaaatga acagcctaaa acctgaagac acggccgttt attactgtgc agtcgatacg       300
aggaatgtaa tcggcccaag agcgggagac tactggggcc aggggaccca ggtcaccgtc       360
tccagt                                                                  366

<210>  81
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  81
Ser Ile Asn Ser Gly Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  82
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  82
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Ser Gly Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  83
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  83
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attaatagtg gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  84
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  84
Ser Ile Ser Ser Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  85
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  85
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  86
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  86
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attagtagta gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  87
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  87
Ser Ile Gly Ser Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  88
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  88
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Gly Ser Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  89
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  89
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attggtagta gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  90
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  90
Ser Ile Tyr Ser Gly Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  91
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  91
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Tyr Ser Gly Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  92
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  92
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct atttacagtg gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  93
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  93
Ser Ile Asn Asn Ser Asp Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  94
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  94
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Ser Asp Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  95
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  95
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attaatagtg acagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  96
<211>  17
<212>  PRT
<213>  artificial sequence

<400>  96
Ser Ile Asn Ser Gly Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210>  97
<211>  115
<212>  PRT
<213>  artificial sequence

<400>  97
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210>  98
<211>  345
<212>  DNA
<213>  artificial sequence

<400>  98
gaggtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgcgactc        60
tcctgtgcag cctctggatt caccttcagt agctactgga tgtattggct ccgtcaggct       120
ccagggaagg ggctcgagtg ggtctcatct attagtggta gtagtagtag cacatactat       180
cgagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat       240
ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatcct       300
ggtgggtacg ccaaaggcca ggggacccag gtcaccgtct ccagt                       345

<210>  99
<211>  226
<212>  PRT
<213>  artificial sequence

<400>  99
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly 
225     

<210>  100
<211>  21
<212>  PRT
<213>  artificial sequence

<400>  100
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly 
            20      

<210>  101
<211>  136
<212>  PRT
<213>  artificial sequence

<400>  101
Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      
Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          
Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              
Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  
Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  
Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      
Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         
Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             
Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135     

<210>  102
<211>  498
<212>  PRT
<213>  artificial sequence

<400>  102
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Ser Asp Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        115                 120                 125             
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    130                 135                 140                 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
145                 150                 155                 160 
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                165                 170                 175     
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            180                 185                 190         
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        195                 200                 205             
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    210                 215                 220                 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
225                 230                 235                 240 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                245                 250                 255     
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            260                 265                 270         
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        275                 280                 285             
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    290                 295                 300                 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
305                 310                 315                 320 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                325                 330                 335     
Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ile Pro Pro His Val Gln 
        355                 360                 365             
Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
    370                 375                 380                 
Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys 
385                 390                 395                 400 
Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys 
                405                 410                 415     
Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu 
            420                 425                 430         
Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His 
        435                 440                 445             
Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu 
    450                 455                 460                 
Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp 
465                 470                 475                 480 
Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn 
                485                 490                 495     
Pro Asp 
        

<210>  103
<211>  23
<212>  DNA
<213>  artificial sequence

<400>  103
gtcctggctg ctcttctaca agg                                                23

<210>  104
<211>  23
<212>  DNA
<213>  artificial sequence

<400>  104
ggtacgtgct gttgaactgt tcc                                                23

<210>  105
<211>  33
<212>  DNA
<213>  artificial sequence

<400>  105
ctagtgcggc cgcctggaga cggtgacctg ggt                                     33

<210>  106
<211>  38
<212>  DNA
<213>  artificial sequence

<400>  106
cgcggatccc aggtgcagct gcaggagtct ggrggagg                                38

<210>  107
<211>  89
<212>  DNA
<213>  artificial sequence

<400>  107
atttttactg ctgttttatt cgcagcatcc tccgcattag ctaaaagaga ggctgaagca        60
caggtgcagc tgcaggagtc tggrggagg                                          89

<210>  108
<211>  81
<212>  DNA
<213>  artificial sequence

<400>  108
agttgtcagt tcctgtgccc cccctcctcc cgcgccacct ccgcccgcac ctccgccacc        60
actggagacg gtgacctggg t                                                  81

<210>  109
<211>  123
<212>  PRT
<213>  artificial sequence

<400>  109
Met Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      
Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          
Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              
Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  
Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  
Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      
Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         
Val Asn Ala Pro Tyr His His His His His His 
        115                 120             

<210>  110
<211>  341
<212>  PRT
<213>  artificial sequence

<400>  110
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Ser Asp Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        115                 120                 125             
Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    130                 135                 140                 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
145                 150                 155                 160 
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                165                 170                 175     
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            180                 185                 190         
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        195                 200                 205             
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    210                 215                 220                 
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
225                 230                 235                 240 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                245                 250                 255     
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            260                 265                 270         
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        275                 280                 285             
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    290                 295                 300                 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
305                 310                 315                 320 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                325                 330                 335     
Ser Leu Ser Pro Gly 
            340     

<210>  111
<211>  117
<212>  PRT
<213>  artificial sequence

<400>  111
Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Trp Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Asn Ser Asp Ser Ser Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Pro Gly Gly Tyr Ala Lys Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser Asp Lys 
        115         

