                         SEQUENCE LISTING

<110>  EUROIMMUN Medizinische Labordiagnostika AG - a PerkinElmer 
       company
 
<120>  Improved detection of NMDA receptor autoantibodies

<130>  19PP055EP

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  938
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Asp 
    850                 855                 860                 


Arg Lys Ser Gly Arg Ala Glu Pro Asp Pro Lys Lys Lys Ala Thr Phe 
865                 870                 875                 880 


Arg Ala Ile Thr Ser Thr Leu Ala Ser Ser Phe Lys Arg Arg Arg Ser 
                885                 890                 895     


Ser Lys Asp Thr Ser Thr Gly Gly Gly Arg Gly Ala Leu Gln Asn Gln 
            900                 905                 910         


Lys Asp Thr Val Leu Pro Arg Arg Ala Ile Glu Arg Glu Glu Gly Gln 
        915                 920                 925             


Leu Gln Leu Cys Ser Arg His Arg Glu Ser 
    930                 935             


<210>  2
<211>  1258
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly 
    1250                 1255             


<210>  3
<211>  8431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid used for transiently expressing human NR1 in cells

<400>  3
ggggaattgt gagcggataa caattccccg gagttaatcc gggaccttta attcaaccca       60

acacaatata ttatagttaa ataagaatta ttatcaaatc atttgtatat taattaaaat      120

actatactgt aaattacatt ttatttacaa tcaaaggaga tataccatgt ctaccatgcg      180

cctgctgacg ctcgccctgc tgttctcctg ctccgtcgcc cgtgccgcgt gcgaccccaa      240

gatcgtcaac attggcgcgg tgctgagcac gcggaagcac gagcagatgt tccgcgaggc      300

cgtgaaccag gccaacaagc ggcacggctc ctggaagatt cagctcaatg ccacctccgt      360

cacgcacaag cccaacgcca tccagatggc tctgtcggtg tgcgaggacc tcatctccag      420

ccaggtctac gccatcctag ttagccatcc acctaccccc aacgaccact tcactcccac      480

ccctgtctcc tacacagccg gcttctaccg catacccgtg ctggggctga ccacccgcat      540

gtccatctac tcggacaaga gcatccacct gagcttcctg cgcaccgtgc cgccctactc      600

ccaccagtcc agcgtgtggt ttgagatgat gcgtgtctac agctggaacc acatcatcct      660

gctggtcagc gacgaccacg agggccgggc ggctcagaaa cgcctggaga cgctgctgga      720

ggagcgtgag tccaaggcag agaaggtgct gcagtttgac ccagggacca agaacgtgac      780

ggccctgctg atggaggcga aagagctgga ggcccgggtc atcatccttt ctgccagcga      840

ggacgatgct gccactgtat accgcgcagc cgcgatgctg aacatgacgg gctccgggta      900

cgtgtggctg gtcggcgagc gcgagatctc ggggaacgcc ctgcgctacg ccccagacgg      960

catcctcggg ctgcagctca tcaacggcaa gaacgagtcg gcccacatca gcgacgccgt     1020

gggcgtggtg gcccaggccg tgcacgagct cctcgagaag gagaacatca ccgacccgcc     1080

gcggggctgc gtgggcaaca ccaacatctg gaagaccggg ccgctcttca agagagtgct     1140

gatgtcttcc aagtatgcgg atggggtgac tggtcgcgtg gagttcaatg aggatgggga     1200

ccggaagttc gccaactaca gcatcatgaa cctgcagaac cgcaagctgg tgcaagtggg     1260

catctacaat ggcacccacg tcatccctaa tgacaggaag atcatctggc caggcggaga     1320

gacagagaag cctcgagggt accagatgtc caccagactg aagattgtga cgatccacca     1380

ggagcccttc gtgtacgtca agcccacgct gagtgatggg acatgcaagg aggagttcac     1440

agtcaacggc gacccagtca agaaggtgat ctgcaccggg cccaacgaca cgtcgccggg     1500

cagcccccgc cacacggtgc ctcagtgttg ctacggcttt tgcatcgacc tgctcatcaa     1560

gctggcacgg accatgaact tcacctacga ggtgcacctg gtggcagatg gcaagttcgg     1620

cacacaggag cgggtgaaca acagcaacaa gaaggagtgg aatgggatga tgggcgagct     1680

gctcagcggg caggcagaca tgatcgtggc gccgctaacc ataaacaacg agcgcgcgca     1740

gtacatcgag ttttccaagc ccttcaagta ccagggcctg actattctgg tcaagaagga     1800

gattccccgg agcacgctgg actcgttcat gcagccgttc cagagcacac tgtggctgct     1860

ggtggggctg tcggtgcacg tggtggccgt gatgctgtac ctgctggacc gcttcagccc     1920

cttcggccgg ttcaaggtga acagcgagga ggaggaggag gacgcactga ccctgtcctc     1980

ggccatgtgg ttctcctggg gcgtcctgct caactccggc atcggggaag gcgcccccag     2040

atcgttctca gcgcgcatcc tgggcatggt gtgggccggc tttgccatga tcatcgtggc     2100

ctcctacacc gccaacctgg cggccttcct ggtgctggac cggccggagg agcgcatcac     2160

gggcatcaac gaccctcggc tgaggaaccc ctcggacaag tttatctacg ccacggtgaa     2220

gcagagctcc gtggatatct acttccggcg ccaggtggag ctgagcacca tgtaccggca     2280

tatggagaag cacaactacg agagtgcggc ggaggccatc caggccgtga gagacaacaa     2340

gctgcatgcc ttcatctggg actcggcggt gctggagttc gaggcctcgc agaagtgcga     2400

cctggtgacg actggagagc tgtttttccg ctcgggcttc ggcataggca tgcgcaaaga     2460

cagcccctgg aagcagaacg tctccctgtc catcctcaag tcccacgaga atggcttcat     2520

ggaagacctg gacaagacgt gggttcggta tcaggaatgt gactcgcgca gcaacgcccc     2580

tgcgaccctt acttttgaga acatggccgg ggtcttcatg ctggtagctg ggggcatcgt     2640

ggccgggatc ttcctgattt tcatcgagat tgcctacaag cggcacaagg atgctcgccg     2700

gaagcagatg cagctggcct ttgccgccgt taacgtgtgg cggaagaacc tgcaggatag     2760

aaagagtggt agagcagagc ctgaccctaa aaagaaagcc acatttaggg ctatcacctc     2820

caccctggct tccagcttca agaggcgtag gtcctccaaa gacacgagca ccgggggtgg     2880

acgcggcgct ttgcaaaacc aaaaagacac agtgctgccg cgacgcgcta ttgagaggga     2940

ggagggccag ctgcagctgt gttcccgtca tagggagagc taactcgagc accaccatca     3000

ccatcaccat cactaagtga ttaacctcag gtgcaggctg cctatcagaa ggtggtggct     3060

ggtgtggcca atgccctggc tcacaaatac cactgagatc gatctttttc cctctgccaa     3120

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     3180

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacatatgg     3240

gagggcaaat catttaaaac atcagaatga gtatttggtt tagagtttgg caacatatgc     3300

ccatatgtaa ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct     3360

gaaagcatgc ggaggaaatt ctccttgaag tttccctggt gttcaaagta aaggagtttg     3420

caccagacgc acctctgttc actggtccgg cgtattaaaa cacgatacat tgttattagt     3480

acatttatta agcgctagat tctgtgcgtt gttgatttac agacaattgt tgtacgtatt     3540

ttaataattc attaaattta taatctttag ggtggtatgt tagagcgaaa atcaaatgat     3600

tttcagcgtc tttatatctg aatttaaata ttaaatcctc aatagatttg taaaataggt     3660

ttcgattagt ttcaaacaag ggttgttttt ccgaaccgat ggctggacta tctaatggat     3720

tttcgctcaa cgccacaaaa cttgccaaat cttgtagcag caatctagct ttgtcgatat     3780

tcgtttgtgt tttgttttgt aataaaggtt cgacgtcgtt caaaatatta tgcgcttttg     3840

tatttctttc atcactgtcg ttagtgtaca attgactcga cgtaaacacg ttaaatagag     3900

cttggacata tttaacatcg ggcgtgttag ctttattagg ccgattatcg tcgtcgtccc     3960

aaccctcgtc gttagaagtt gcttccgaag acgattttgc catagccaca cgacgcctat     4020

taattgtgtc ggctaacacg tccgcgatca aatttgtagt tgagcttttt ggaattattt     4080

ctgattgcgg gcgtttttgg gcgggtttca atctaactgt gcccgatttt aattcagaca     4140

acacgttaga aagcgatggt gcaggcggtg gtaacatttc agacggcaaa tctactaatg     4200

gcggcggtgg tggagctgat gataaatcta ccatcggtgg aggcgcaggc ggggctggcg     4260

gcggaggcgg aggcggaggt ggtggcggtg atgcagacgg cggtttaggc tcaaatgtct     4320

ctttaggcaa cacagtcggc acctcaacta ttgtactggt ttcgggcgcc gtttttggtt     4380

tgaccggtct gagacgagtg cgattttttt cgtttctaat agcttccaac aattgttgtc     4440

tgtcgtctaa aggtgcagcg ggttgaggtt ccgtcggcat tggtggagcg ggcggcaatt     4500

cagacatcga tggtggtggt ggtggtggag gcgctggaat gttaggcacg ggagaaggtg     4560

gtggcggcgg tgccgccggt ataatttgtt ctggtttagt ttgttcgcgc acgattgtgg     4620

gcaccggcgc aggcgccgct ggctgcacaa cggaaggtcg tctgcttcga ggcagcgctt     4680

ggggtggtgg caattcaata ttataattgg aatacaaatc gtaaaaatct gctataagca     4740

ttgtaatttc gctatcgttt accgtgccga tatttaacaa ccgctcaatg taagcaattg     4800

tattgtaaag agattgtctc aagctcggaa cgctgcgctc ggtcgttcgg ctgcggcgag     4860

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     4920

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     4980

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     5040

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     5100

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     5160

cgggaagcgt ggcgctttct caatgctcac gctgtaggta tctcagttcg gtgtaggtcg     5220

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     5280

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     5340

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     5400

ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct ctgctgaagc     5460

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     5520

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     5580

atcctttgtt accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt     5640

tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca     5700

tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca     5760

gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc     5820

tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt     5880

ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg     5940

gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc     6000

aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg     6060

ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga     6120

tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga     6180

ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta     6240

aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg     6300

ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact     6360

ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata     6420

agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt     6480

tatcagggtt attgtctcat gtccgcgcgt ttcctgcatc ttttaatcaa atcccaagat     6540

gtgtataaac caccaaactg ccaaaaaatg aaaactgtcg acaagctctg tccgtttgct     6600

ggcaactgca agggtctcaa tcctatttgt aattattgaa taataaaaca attataaatg     6660

tcaaatttgt tttttattaa cgatacaaac caaacgcaac aagaacattt gtagtattat     6720

ctataattga aaacgcgtag ttataatcgc tgaggtaata tttaaaatca ttttcaaatg     6780

attcacagtt aatttgcgac aatataattt tattttcaca taaactagac gccttgtcgt     6840

cttcttcttc gtattccttc tctttttcat ttttctcttc ataaaaatta acatagttat     6900

tatcgtatcc atatatgtat ctatcgtata gagtaaattt tttgttgtca taaatatata     6960

tgtctttttt aatggggtgt atagtaccgc tgcgcatagt ttttctgtaa tttacaacag     7020

tgctattttc tggtagttct tcggagtgtg ttgctttaat tattaaattt atataatcaa     7080

tgaatttggg atcgtcggtt ttgtacaata tgttgccggc atagtacgca gcttcttcta     7140

gttcaattac accatttttt agcagcaccg gattaacata actttccaaa atgttgtacg     7200

aaccgttaaa caaaaacagt tcacctccct tttctatact attgtctgcg agcagttgtt     7260

tgttgttaaa aataacagcc attgtaatga gacgcacaaa ctaatatcac aaactggaaa     7320

tgtctatcaa tatatagttg ctctagttat taatagtaat caattacggg gtcattagtt     7380

catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga     7440

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca     7500

atagggactt tccattgacg tcaatgggtg gactatttac ggtaaactgc ccacttggca     7560

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg     7620

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc     7680

tacgtattag tcatcgctat taccatgcat ggtcgaggtg agccccacgt tctgcttcac     7740

tctccccatc tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt     7800

ttgtgcagcg atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg     7860

cgaggggcgg ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct     7920

ccgaaagttt ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc     7980

gcggcgggcg ggagtcgctg cgacgctgcc ttcgccccgt gccccgctcc gccgccgcct     8040

cgcgccgccc gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg     8100

gcccttctcc ttcgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt     8160

ggctgcgtga aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg     8220

ggctgtccgc ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc     8280

tggcgtgtga ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc     8340

ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattg     8400

gatcggaccg aaattaatac gactcactat a                                    8431


<210>  4
<211>  1484
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Val Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val 
    1475                 1480                 


<210>  5
<211>  7779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid used for permanently expressing or stable transfection of
       human NR1 in cells

<400>  5
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggaacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ccctatcagt gatagagatc      840

tccctatcag tgatagagat cgtcgacgag ctcgtttagt gaaccgtcag atcgcctgaa      900

gctgggtacc agctgctagc aagcttgccg ccgacatgtc taccatgcgc ctgctgacgc      960

tcgccctgct gttctcctgc tccgtcgccc gtgccgcgtg cgaccccaag atcgtcaaca     1020

ttggcgcggt gctgagcacg cggaagcacg agcagatgtt ccgcgaggcc gtgaaccagg     1080

ccaacaagcg gcacggctcc tggaagattc agctcaatgc cacctccgtc acgcacaagc     1140

ccaacgccat ccagatggct ctgtcggtgt gcgaggacct catctccagc caggtctacg     1200

ccatcctagt tagccatcca cctaccccca acgaccactt cactcccacc cctgtctcct     1260

acacagccgg cttctaccgc atacccgtgc tggggctgac cacccgcatg tccatctact     1320

cggacaagag catccacctg agcttcctgc gcaccgtgcc gccctactcc caccagtcca     1380

gcgtgtggtt tgagatgatg cgtgtctaca gctggaacca catcatcctg ctggtcagcg     1440

acgaccacga gggccgggcg gctcagaaac gcctggagac gctgctggag gagcgtgagt     1500

ccaaggcaga gaaggtgctg cagtttgacc cagggaccaa gaacgtgacg gccctgctga     1560

tggaggcgaa agagctggag gcccgggtca tcatcctttc tgccagcgag gacgatgctg     1620

ccactgtata ccgcgcagcc gcgatgctga acatgacggg ctccgggtac gtgtggctgg     1680

tcggcgagcg cgagatctcg gggaacgccc tgcgctacgc cccagacggc atcctcgggc     1740

tgcagctcat caacggcaag aacgagtcgg cccacatcag cgacgccgtg ggcgtggtgg     1800

cccaggccgt gcacgagctc ctcgagaagg agaacatcac cgacccgccg cggggctgcg     1860

tgggcaacac caacatctgg aagaccgggc cgctcttcaa gagagtgctg atgtcttcca     1920

agtatgcgga tggggtgact ggtcgcgtgg agttcaatga ggatggggac cggaagttcg     1980

ccaactacag catcatgaac ctgcagaacc gcaagctggt gcaagtgggc atctacaatg     2040

gcacccacgt catccctaat gacaggaaga tcatctggcc aggcggagag acagagaagc     2100

ctcgagggta ccagatgtcc accagactga agattgtgac gatccaccag gagcccttcg     2160

tgtacgtcaa gcccacgctg agtgatggga catgcaagga ggagttcaca gtcaacggcg     2220

acccagtcaa gaaggtgatc tgcaccgggc ccaacgacac gtcgccgggc agcccccgcc     2280

acacggtgcc tcagtgttgc tacggctttt gcatcgacct gctcatcaag ctggcacgga     2340

ccatgaactt cacctacgag gtgcacctgg tggcagatgg caagttcggc acacaggagc     2400

gggtgaacaa cagcaacaag aaggagtgga atgggatgat gggcgagctg ctcagcgggc     2460

aggcagacat gatcgtggcg ccgctaacca taaacaacga gcgcgcgcag tacatcgagt     2520

tttccaagcc cttcaagtac cagggcctga ctattctggt caagaaggag attccccgga     2580

gcacgctgga ctcgttcatg cagccgttcc agagcacact gtggctgctg gtggggctgt     2640

cggtgcacgt ggtggccgtg atgctgtacc tgctggaccg cttcagcccc ttcggccggt     2700

tcaaggtgaa cagcgaggag gaggaggagg acgcactgac cctgtcctcg gccatgtggt     2760

tctcctgggg cgtcctgctc aactccggca tcggggaagg cgcccccaga tcgttctcag     2820

cgcgcatcct gggcatggtg tgggccggct ttgccatgat catcgtggcc tcctacaccg     2880

ccaacctggc ggccttcctg gtgctggacc ggccggagga gcgcatcacg ggcatcaacg     2940

accctcggct gaggaacccc tcggacaagt ttatctacgc cacggtgaag cagagctccg     3000

tggatatcta cttccggcgc caggtggagc tgagcaccat gtaccggcat atggagaagc     3060

acaactacga gagtgcggcg gaggccatcc aggccgtgag agacaacaag ctgcatgcct     3120

tcatctggga ctcggcggtg ctggagttcg aggcctcgca gaagtgcgac ctggtgacga     3180

ctggagagct gtttttccgc tcgggcttcg gcataggcat gcgcaaagac agcccctgga     3240

agcagaacgt ctccctgtcc atcctcaagt cccacgagaa tggcttcatg gaagacctgg     3300

acaagacgtg ggttcggtat caggaatgtg actcgcgcag caacgcccct gcgaccctta     3360

cttttgagaa catggccggg gtcttcatgc tggtagctgg gggcatcgtg gccgggatct     3420

tcctgatttt catcgagatt gcctacaagc ggcacaagga tgctcgccgg aagcagatgc     3480

agctggcctt tgccgccgtt aacgtgtggc ggaagaacct gcaggataga aagagtggta     3540

gagcagagcc tgaccctaaa aagaaagcca catttagggc tatcacctcc accctggctt     3600

ccagcttcaa gaggcgtagg tcctccaaag acacgagcac cgggggtgga cgcggcgctt     3660

tgcaaaacca aaaagacaca gtgctgccgc gacgcgctat tgagagggag gagggccagc     3720

tgcagctgtg ttcccgtcat agggagagct gactcgagtc tagagggccc gtttaaaccc     3780

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     3840

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     3900

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     3960

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg     4020

cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg ccctgtagcg     4080

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     4140

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     4200

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     4260

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     4320

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     4380

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     4440

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct     4500

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     4560

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     4620

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     4680

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     4740

aatttttttt atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta     4800

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc     4860

cattttcgga tctgatcagc acgtgttgac aattaatcat cggcatagta tatcggcata     4920

gtataatacg acaaggtgag gaactaaacc atggccaagt tgaccagtgc cgttccggtg     4980

ctcaccgcgc gcgacgtcgc cggagcggtc gagttctgga ccgaccggct cgggttctcc     5040

cgggacttcg tggaggacga cttcgccggt gtggtccggg acgacgtgac cctgttcatc     5100

agcgcggtcc aggaccaggt ggtgccggac aacaccctgg cctgggtgtg ggtgcgcggc     5160

ctggacgagc tgtacgccga gtggtcggag gtcgtgtcca cgaacttccg ggacgcctcc     5220

gggccggcca tgaccgagat cggcgagcag ccgtgggggc gggagttcgc cctgcgcgac     5280

ccggccggca actgcgtgca cttcgtggcc gaggagcagg actgacacgt gctacgagat     5340

ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc     5400

ggctggatga tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg     5460

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     5520

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat     5580

gtctgtatac cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct     5640

gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt     5700

aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc     5760

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg     5820

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     5880

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5940

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     6000

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     6060

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     6120

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     6180

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     6240

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     6300

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     6360

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     6420

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     6480

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     6540

aaacaaacca ccgctggtag cggttttttt gtttgcaagc agcagattac gcgcagaaaa     6600

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     6660

aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt     6720

ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac ttggtctgac     6780

agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt tcgttcatcc     6840

atagttgcct gactccccgt cgtgtagata actacgatac gggagggctt accatctggc     6900

cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt atcagcaata     6960

aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc cgcctccatc     7020

cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc     7080

aacgttgttg ccattgctac aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca     7140

ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa     7200

gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc agtgttatca     7260

ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt aagatgcttt     7320

tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt     7380

tgctcttgcc cggcgtcaat acgggataat accgcgccac atagcagaac tttaaaagtg     7440

ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc gctgttgaga     7500

tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt tactttcacc     7560

agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg aataagggcg     7620

acacggaaat gttgaatact catactcttc ctttttcaat attattgaag catttatcag     7680

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     7740

gttccgcgca catttccccg aaaagtgcca cctgacgtc                            7779


<210>  6
<211>  8967
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid used for transiently expressing rat NR1 in cells

<400>  6
ttcgagctcg cccgacattg attattgact agttattaat agtaatcaat tacggggtca       60

ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct      120

ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta      180

acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac      240

ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt      300

aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag      360

tacatctacg tattagtcat cgctattacc atggtgatgc ggttttggca gtacatcaat      420

gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat      480

gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc      540

ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt      600

ttagtgaacc gtcagatcgc ctggagacgc catccacgct gttttgacct ccatagaaga      660

caccgggacc gatccagcct ccgcggccgg gaacggtgca ttggaacgcg gattccccgt      720

gccaagagtg acgtaagtac cgcctataga gtctataggc ccaccccctt ggcttcgtta      780

gaacgcggct acaattaata cataacctta tgtatcatac acatacgatt taggtgacac      840

tatagaataa catccacttt gcctttctct ccacaggtgt ccactcccag gtccaactgc      900

acctcggttc taagcttgat atcgaattcc gttgctgtcg aatattggtt tgttaaggca      960

gtttctgtag aggtttctaa gagaccagtc gcgcagtccg cgctgctgtc ctttccgcct     1020

tttccgcgcg ggtgttcgag cagcgccaaa cacgcttcag cacctcggac agcatccgcc     1080

gcgctcgccc ggggctccta gagaacccgg gggcgcttga ccgcgcgcgg gcggcccgcg     1140

ggtcgtacat cgcgaggtcg tcgcactcgc gcaacccaga gccaggcccg ctgtgcccgg     1200

agctcatgag caccatgcac ctgctgacat tcgccctgct tttttcctgc tccttcgccc     1260

gcgccgcctg cgaccccaag atcgtcaaca tcggcgcggt gctgagcacg cgcaagcatg     1320

aacagatgtt ccgcgaggca gtaaaccagg ccaataagcg acacggctct tggaagatac     1380

agctcaacgc cacttctgtc acccacaagc ccaacgccat acagatggcc ctgtcagtgt     1440

gtgaggacct catctctagc caggtctacg ctatcctagt tagccacccg cctactccca     1500

acgaccactt cactcccacc cctgtctcct acacagctgg cttctacaga atccctgtcc     1560

tgggactgac tacccgaatg tccatctact ctgacaagag tatccacctg agtttccttc     1620

gcacggtgcc gccctactcc caccagtcca gcgtctggtt tgagatgatg cgagtctaca     1680

actggaacca catcatcctg ctggtcagcg acgaccacga gggacgggca gcgcagaagc     1740

gcttggagac gttgctggag gaacgggagt ccaaggcaga gaaggtgctg cagtttgacc     1800

caggaaccaa gaatgtgacg gctctgctga tggaggcccg ggaactggag gcccgggtca     1860

tcatcctttc tgcaagcgag gacgacgctg ccacagtgta ccgcgcagcc gcaatgctga     1920

acatgacggg ctctgggtac gtgtggctgg tcggggaacg cgagatctct gggaacgccc     1980

tgcgctacgc tcctgatggc atcatcggac ttcagctcat caatggcaag aatgagtcag     2040

cccacatcag tgacgccgtg ggcgtggtgg cacaggcagt tcacgaactc ctagagaagg     2100

agaatatcac tgacccaccg cggggttgcg tgggcaacac caacatctgg aagacaggac     2160

cattgttcaa gagggtgctg atgtcttcta agtatgcgga cggagtgact ggccgtgtgg     2220

aattcaatga ggatggggac cggaagtttg ccaactatag tatcatgaac ctgcagaacc     2280

gcaagctggt gcaagtgggc atctacaatg gtacccatgt catcccaaat gacaggaaga     2340

tcatctggcc aggaggagag acagagaaac ctcgaggata ccagatgtcc accagactaa     2400

agatagtgac aatccaccaa gagcccttcg tgtacgtcaa gcccacaatg agtgatggga     2460

catgcaaaga ggagttcaca gtcaatggtg acccagtgaa gaaggtgatc tgtacggggc     2520

ctaatgacac gtccccaggc agcccacgcc acacagtgcc ccagtgctgc tatggcttct     2580

gcatagacct gctcatcaag ctggcgcgga ccatgaattt tacctatgag gtgcacctgg     2640

tggcagatgg caagtttggc acacaggagc gggtaaacaa cagcaacaaa aaggagtgga     2700

acggaatgat gggcgagcta ctcagtggcc aagcggacat gattgtggca ccactgacca     2760

tcaacaatga gcgtgcgcag tacatagagt tctccaagcc cttcaagtac cagggcctga     2820

ccattttggt caagaaggag attcccagga gcacactgga ctcatttatg cagccttttc     2880

agagcacact gtggttgcta gtaggactgt cagttcatgt ggtggctgtg atgctgtacc     2940

tgctggaccg cttcagtccc tttggccgat tcaaggtgaa cagtgaggag gaggaggaag     3000

atgcactgac cctgtcctct gccatgtggt tttcctgggg cgtcctgctc aactccggca     3060

ttggggaagg tgccccccgg agtttctctg cacgtatcct aggcatggtg tgggctggtt     3120

tcgccatgat catagtggct tcctacactg ccaacttggc agctttcctg gtgctggatc     3180

ggcctgagga gcgcatcacg ggcatcaatg accccaggct cagaaacccc tcagacaagt     3240

tcatctacgc aactgtaaag cagagctccg tggacatcta cttccggagg caggtggagt     3300

tgagtaccat gtaccggcac atggaaaaac acaattacga gagcgcagct gaggccatcc     3360

aggctgtgcg ggacaacaag ctgcacgcct ttatctggga ctcggccgtg ctggagtttg     3420

aggcttcaca gaagtgcgat ctggtgacca cgggtgagct gttcttccgc tcaggctttg     3480

gcatcggcat gcgcaaggac agcccctgga agcagaacgt ttccctgtcc atactcaagt     3540

cccatgagaa tggcttcatg gaagatctgg ataagacatg ggttcggtat caggaatgcg     3600

actcccgcag caatgctcct gcaaccctca cttttgagaa catggcaggg gtcttcatgc     3660

tggtggctgg aggcatcgta gctgggattt tcctcatttt cattgagatc gcctacaagc     3720

gacacaagga tgcccgtagg aagcagatgc agctggcttt tgcagccgtg aacgtgtgga     3780

ggaagaacct gcaggataga aagagtggta gagcagagcc cgaccctaaa aagaaagcca     3840

catttagggc tatcacctcc accctggcct ccagcttcaa gagacgtagg tcctccaaag     3900

acacgagcac cgggggtgga cgcggcgctt tgcaaaacca aaaagacaca gtgctgccgc     3960

gacgcgctat tgagagggag gagggccagc tgcagctgtg ttcccgtcat agggagagct     4020

gagacgcccc gcccgccctc ctctgcccct cccccgcaga cagacgcacg ggacagcggc     4080

ctggcccacg cagagccccg gagcacgacg gggtcggggg aggagcactc ccagcctccc     4140

ccaggccgtg cccgcctgcc caccggtcgg ccggctggcc ggtccaccct gtcccggccc     4200

cgcgcgtgcc cccgacgtcg gagctaacgg gccgccttgt ctgtgtattt ctattttaca     4260

gcagtaccat cccactgata tcacgggccc gctcaacctc tcagatccct cggtcagcac     4320

cgtggtgtga ggccccccgg aggcgcccac ctgcccagtt agcccggcca aggacactga     4380

tgagtcctgc tgctcgggaa ggcctgaggg aagcccaccc gccccagaga ctgcccaccc     4440

tgggcctccc gtccgcctgc tctgctgcct ggcgggcagc ccctgcagga ccaaggtgcg     4500

gaccagagcg gctgaggatg ggccagagct gagccggctg ggcagggcca cagggcgctc     4560

cggcagaggc agggccctga ggtctctgag cagtggggtg aggggcctaa gtggccccgg     4620

tcggaggagt ctggagcaga aatggcagcc ccatccttcc tccagccact accccaagct     4680

acagtggggg cctatggccc cagcttgcta ggtcaccccc gacccttcct ccagcgcctg     4740

ctctctgcaa cttgatttcc acctctctcc tgctgcacca ccctcccacg acatttcccc     4800

accccattca ctgggttgtc tctgaccttt cccagggcta gccttcactg ccctagtggc     4860

agtgcttcag gggtgctttc tggctcccag acatctaggg ctccagactc caagagggct     4920

gagccttctc ttctgtccgc agccacaata ggcttcctca gacgctggct cgtgatgagt     4980

cccgcacctt gggcaccagg gagcgccatc tgcctcccag tccggtgtca ctcaccccac     5040

taccttgtac atgaccagct ctcccagtgt cccagtgtct gccccaggga caccgggcgc     5100

gcacagccac ccctaatccc ggtattcagt ggtgatgcct aaaggaatgt cagaaaaaaa     5160

aaaaaaaagc ggccgctcga gcatgcatct agaggatccc cggggaattc aatcgatggc     5220

cgccatggcc caacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     5280

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     5340

tcaatgtatc ttatcatgtc tggatcgatc gggaattaat tcggcgcagc accatggcct     5400

gaaataacct ctgaaagagg aacttggtta ggtaccttct gaggcggaaa gaaccagctg     5460

tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg cagaagtatg     5520

caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg ctccccagca     5580

ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc gcccctaact     5640

ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta     5700

atttttttta tttatgcaga ggccgaggcc gcctcggcct gtgagctatt ccagaagtag     5760

tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tgttaacagc ttggcactgg     5820

ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg     5880

cagcacatcc ccccttcgcc acctggcgta atagcgaaga ggcccgcacc gatcgccctt     5940

cccaacagtt gcgtagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc     6000

atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtacggg     6060

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     6120

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     6180

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     6240

cgaccccaaa aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc cctgatagac     6300

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     6360

tggaacaaca ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat     6420

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     6480

aatattaacg tttacaattt tatggtgcac tctcagtaca atctgctctg atgccgcata     6540

gttaagccaa ctccgctatc gctacgtgac tgggtcatgg ctgcgccccg acacccgcca     6600

acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct     6660

gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg     6720

aggcagtatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     6780

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     6840

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     6900

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     6960

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     7020

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat ggaactggat     7080

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     7140

acttttaaag ttctgctatg tggcgcggta ttatcccgtg atgacgccgg gcaagagcaa     7200

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agccacagaa     7260

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     7320

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     7380

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     7440

gaagccatac caaacgacga gcgtgacacc acgatgccag cagcaatggc aacaacgttg     7500

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     7560

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     7620

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg     7680

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     7740

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     7800

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     7860

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     7920

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     7980

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     8040

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     8100

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     8160

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     8220

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     8280

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     8340

agatacctac agcgtgagca ttgagaaagc gccacgcttc ccgaagggag aaaggcggac     8400

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     8460

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     8520

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     8580

cggttcctgg ccttttggtg gccttttgct cacatgttct ttcctgcgtt atcccctgat     8640

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     8700

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct     8760

ctccccgcgc gttggccgat tcattaatcc agctggcacg acaggtttcc cgactggaaa     8820

gcgggcagtg agcgcaacgc aattaatgtg agttacctca ctcattaggc accccaggct     8880

ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac     8940

acaggaaaca gctatgacca tgattac                                         8967


