SEQCENCE LISTING

<110> Applicant: Immunoadoptive Cell Therapy Pvt. Ltd
<120> Title : INDUCIBLE CYTOKINE SIGNALS AND METHODS FOR IMMUNOTHERAPY
<130> AppFileReference : IIT-KR
<140> CurrentAppNumber : 201921036138
<141> CurrentFilingDate : 08 Sep 2019

<170> PatentIn ver 3.5

<201> 1
<211> 21
<212> PRT
<213> Artificial Sequence
<221> CD8 alpha leader peptide amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR P                                                  21

<201> 2  
<211> 107
<212> PRT
<213> Artificial Sequence
<221> FKBP dimerizing domain amino acid sequence
<400> 
GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKVDSSR DRNKPFKFML GKQEVIRGWE        60
EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLE                     107
     
<201> 3
<211> 10
<212> PRT
<213> Artificial Sequence
<221> Linker amino acid sequence
<400> 
GGGGSGGGGS                                                               10

<201> 4 
<211> 25
<212> PRT
<213> Artificial Sequence
<221> Transmembrane domain of IL-15R  amino acid sequence
<400>  
IPWLGHLLVG LSGAFGFIIL VYLLI                                              25
     
<201> 5
<211> 148
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of IL-15R  amino acid sequence
<400> 
NCRNTGPWLK KVLKCNTPDP SKFFSQLSSE HGGDVQKWLS SPFPSSSFSP GGLAPEISPL        60
EVLERDKVTQ LLLQQDKVPE PASLSSNHSL TSCFTNQGYF FFHLPDALEI EACQVYFTYD       120
PYSEEDPLNT DAYLSLQELQ GQDPTHLV                                          148

<210> 6
<211> 25
<212> PRT
<213> Artificial Sequence
<221> Transmembrane domain of IL-7R  amino acid sequence
<400>  
PILLTISILS FFSVALLVIL ACVLW                                              25

<210> 7
<211> 195
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of IL-7R  amino acid sequence
<400>  
KKRIKPIVWP SLPDHKKTLE HLCKKPRKNL NVSFNPESFL DCQIHRVDDI QARDEVEGFL        60
QDTFPQQLEE SEKQRLGGDV QSPNCPSEDV VITPESFGRD SSLTCLAGNV SACDAPILSS       120
SRSLDCRESG KNGPHVYQDL LLSLGTTNST LPPPFSLQSG ILTLNPVAQG QPILTSLGSN       180
QEEAYVTMSS FYQNQ                                                        195

<210> 8
<211> 21
<212> PRT
<213> Artificial Sequence
<221> Transmembrane domain of IL-21R amino acid sequence
<400>  
GWNPHLLLLL LLVIVFIPAF W                                                  21

<210> 9
<211> 285
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of IL-21R amino acid sequence
<400>  
SLKTHPLWRL WKKIWAVPSP ERFFMPLYKG CSGDFKKWVG APFTGSSLEL GPWSPEVPST        60
LEVYSCHPPR SPAKRLQLTE LQEPAELVES DGVPKPSFWP TAQNSGGSAY SEERDRPYGL       120
VSIDTVTVLD AEGPCTWPCS CEDDGYPALD LDAGLEPSPG LEDPLLDAGT TVLSCGCVSA       180
GSPGLGGPLG SLLDRLKPPL ADGEDWAGGL PWGGRSPGGV SESEAGSPLA GLDMDTFDSG       240
FVGSDCSSPV ECDFTSPGDE GPPRSYLRQW VVIPPPLSSP GPQAS                       285

<210> 10
<211> 21
<212> PRT
<213> Artificial Sequence
<221> Transmembrane domain of gamma c receptor amino acid sequence
<400>  
VVISVGSMGL IISLLCVYFW L                                                  21

<210> 11
<211> 86
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of gamma c receptor amino acid sequence
<400>  
ERTMPRIPTL KNLEDLVTEY HGNFSAWSGV SKGLAESLQP DYSERLCLVS EIPPKGGALG        60
EGPGASPCNQ HSPYWAPPCY TLKPET                                             86

<210> 12
<211> 311
<212> PRT
<213> Artificial Sequence
<221> DICCRE-15 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSIP WLGHLLVGLS GAFGFIILVY LLINCRNTGP WLKKVLKCNT       180
PDPSKFFSQL SSEHGGDVQK WLSSPFPSSS FSPGGLAPEI SPLEVLERDK VTQLLLQQDK       240
VPEPASLSSN HSLTSCFTNQ GYFFFHLPDA LEIEACQVYF TYDPYSEEDP LNTDAYLSLQ       300
ELQGQDPTHL V                                                            311

<210> 13
<211> 358
<212> PRT
<213> Artificial Sequence
<221> DICCRE-7 amino acid sequence 
<400> 
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSPI LLTISILSFF SVALLVILAC VLWKKRIKPI VWPSLPDHKK       180
TLEHLCKKPR KNLNVSFNPE SFLDCQIHRV DDIQARDEVE GFLQDTFPQQ LEESEKQRLG       240
GDVQSPNCPS EDVVITPESF GRDSSLTCLA GNVSACDAPI LSSSRSLDCR ESGKNGPHVY       300
QDLLLSLGTT NSTLPPPFSL QSGILTLNPV AQGQPILTSL GSNQEEAYVT MSSFYQNQ         358

<210> 14
<211> 444
<212> PRT
<213> Artificial Sequence
<221> DICCRE-21 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSGW NPHLLLLLLL VIVFIPAFWS LKTHPLWRLW KKIWAVPSPE       180
RFFMPLYKGC SGDFKKWVGA PFTGSSLELG PWSPEVPSTL EVYSCHPPRS PAKRLQLTEL       240
QEPAELVESD GVPKPSFWPT AQNSGGSAYS EERDRPYGLV SIDTVTVLDA EGPCTWPCSC       300
EDDGYPALDL DAGLEPSPGL EDPLLDAGTT VLSCGCVSAG SPGLGGPLGS LLDRLKPPLA       360
DGEDWAGGLP WGGRSPGGVS ESEAGSPLAG LDMDTFDSGF VGSDCSSPVE CDFTSPGDEG       420
PPRSYLRQWV VIPPPLSSPG PQAS                                              444

<210> 15
<211> 25
<212> PRT
<213> Artificial Sequence
<221> DICCRE-gc amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSVV ISVGSMGLII SLLCVYFWLE RTMPRIPTLK NLEDLVTEYH       180
GNFSAWSGVS KGLAESLQPD YSERLCLVSE IPPKGGALGE GPGASPCNQH SPYWAPPCYT       240
LKPET                                                                   245

<210> 16
<211> 933
<212> DNA
<213> Artificial Sequence
<221> DICCRE-15 nucleotide sequence
<400>  
atggctctgc cagttactgc actgctgctt ccactggcat tgctgcttca tgccgcaaga        60
cctggcgtgc aggtcgagac aatttctcct ggcgacggcc ggacatttcc taagagagga       120
cagacctgcg tcgtgcacta caccggcatg ctggaagatg gaaagaaggt ggacagcagc       180
cgggacagaa acaagccctt caagttcatg ctgggcaagc aagaagtgat tagaggctgg       240
gaagagggcg tcgcccaaat gtctgtggga cagagagcca agctgacaat cagcccagat       300
tacgcctacg gcgccacagg acaccctgga attattcctc cacacgccac actggtgttc       360
gatgtggaac tgctcaaact ggaaggtggc ggtggtagtg gcggtggcgg atctattcct       420
tggctgggac atctgctcgt gggactgagc ggagccttcg gctttatcat cctggtgtac       480
ctgctgatca actgccggaa cacaggcccc tggctgaaga aagtgctgaa gtgcaacacc       540
cctgatccta gcaagttctt tagccagctg tctagcgagc acggcgggga tgttcagaaa       600
tggctcagct ctccatttcc tagctccagc tttagccctg gcggactggc ccctgagatt       660
tctccactgg aagtgctgga acgggacaaa gtgacacagc tgctgctcca gcaggataag       720
gtgccagaac cagccagcct gagcagcaat cacagcctga ccagctgctt taccaaccag       780
ggctacttct tctttcatct gcccgacgca ctggaaatcg aggcctgcca ggtgtacttc       840
acctacgatc cttacagcga agaggaccct ctgaacaccg atgcctacct gagcctgcaa       900
gagctgcagg gccaagatcc tacacacctt gtt                                    933

<210> 17
<211> 735
<212> DNA
<213> Artificial Sequence
<221> DICCRE-gc nucleotide sequence
<400>  
atggcactcc cagtgactgc ccttcttttg cctctggcac ttctgctgca cgcagccaga        60
ccaggtgtcc aggtggaaac tattagccca ggcgacggca gaacctttcc aaagcgggga       120
cagacatgtg tggtgcatta tactggaatg ctcgaggacg gcaagaaagt ggactcctcc       180
agagatcgca acaagccgtt taagtttatg ctcggaaaac aagaagtcat acgcggctgg       240
gaagagggtg tcgctcagat gagtgttggc cagcgggcca aactgaccat ctctcccgat       300
tatgcctatg gcgctaccgg ccatcctggc atcattccac ctcatgctac cctggtgttt       360
gacgtcgagc ttctgaaatt ggaaggcgga ggtggaagcg gaggcggcgg atctgttgtg       420
atttctgtgg gcagcatggg cctgatcatc tccctgctgt gcgtgtactt ttggctggaa       480
agaaccatgc ctcgcatccc cacactgaag aacctggaag atctggtcac cgagtaccac       540
ggcaactttt ctgcttggag cggggtgtcc aaaggactgg ctgaatccct gcagccagat       600
tactctgagc ggctgtgcct ggtgtctgag atccctccta aaggcggagc ccttggagaa       660
ggaccaggcg cctctccatg taaccagcac tctccatatt gggccccacc ttgctacacc       720
ctgaagccag agaca                                                        735

<210> 18
<211> 21
<212> PRT
<213> Artificial Sequence
<221> Transmembrane domain of IL-27R amino acid sequence
<400>  
GWNPHLLLLL LLVIVFIPAF W                                                  21

<210> 19
<211> 22
<212> PRT
<213> Artificial Sequence
<221> Transmembrane domain of IL-6R  amino acid sequence
<400>  
AIVVPVCLAF LLTTLLGVLF CF                                                 22

<210> 20
<211> 99
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of IL-27R amino acid sequence
<400>  
TSGRCYHLRH KVLPRWVWEK VPDPANSSSG QPHMEQVPEA QPLGDLPILE VEEMEPPPVM        60
ESSQPAQATA PLDSGYEKHF LPTPEELGLL GPPRPQVLA                               99

<210> 21
<211> 277
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of IL-6R  amino acid sequence
<400>  
NKRDLIKKHI WPNVPDPSKS HIAQWSPHTP PRHNFNSKDQ MYSDGNFTDV SVVEIEANDK        60
KPFPEDLKSL DLFKKEKINT EGHSSGIGGS SCMSSSRPSI SSSDENESSQ NTSSTVQYST       120
VVHSGYRHQV PSVQVFSRSE STQPLLDSEE RPEDLQLVDH VDGGDGILPR QQYFKQNCSQ       180
HESSPDISHF ERSKQVSSVN EEDFVRLKQQ ISDHISQSCG SGQMKMFQEV SAADAFGPGT       240
EGQVERFETV GMEAATDEGM PKSYLPQTVR QGGYMPQ                                277

<210> 22
<211> 258
<212> PRT
<213> Artificial Sequence
<221> DICCRE-27 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSGW NPHLLLLLLL VIVFIPAFWT SGRCYHLRHK VLPRWVWEKV       180
PDPANSSSGQ PHMEQVPEAQ PLGDLPILEV EEMEPPPVME SSQPAQATAP LDSGYEKHFL       240
PTPEELGLLG PPRPQVLA                                                     258

<210> 23
<211> 437
<212> PRT
<213> Artificial Sequence
<221> DICCRE-IL6Rb amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSAI VVPVCLAFLL TTLLGVLFCF NKRDLIKKHI WPNVPDPSKS       180
HIAQWSPHTP PRHNFNSKDQ MYSDGNFTDV SVVEIEANDK KPFPEDLKSL DLFKKEKINT       240
EGHSSGIGGS SCMSSSRPSI SSSDENESSQ NTSSTVQYST VVHSGYRHQV PSVQVFSRSE       300
STQPLLDSEE RPEDLQLVDH VDGGDGILPR QQYFKQNCSQ HESSPDISHF ERSKQVSSVN       360
EEDFVRLKQQ ISDHISQSCG SGQMKMFQEV SAADAFGPGT EGQVERFETV GMEAATDEGM       420
PKSYLPQTVR QGGYMPQ                                                      437

<210> 24
<211> 286
<212> PRT
<213> Artificial Sequence
<221> Intracellular cytokine signaling domain of IL-15R beta  amino acid sequence
<400>  
NCRNTGPWLK KVLKCNTPDP SKFFSQLSSE HGGDVQKWLS SPFPSSSFSP GGLAPEISPL        60
EVLERDKVTQ LLLQQDKVPE PASLSSNHSL TSCFTNQGYF FFHLPDALEI EACQVYFTYD       120
PYSEEDPDEG VAGAPTGSSP QPLQPLSGED DAYCTFPSRD DLLLFSPSLL GGPSPPSTAP       180
GGSGAGEERM PPSLQERVPR DWDPQPLGPP TPGVPDLVDF QPPPELVLRE AGEEVPDAGP       240
REGVSFPWSR PPGQGEFRAL NARLPLNTDA YLSLQELQGQ DPTHLV                      286

<210> 25
<211> 449
<212> PRT
<213> Artificial Sequence
<221> DICCRE-15 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKVDSS        60
RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD YAYGATGHPG IIPPHATLVF       120
DVELLKLEGG GGSGGGGSIP WLGHLLVGLS GAFGFIILVY LLINCRNTGP WLKKVLKCNT       180
PDPSKFFSQL SSEHGGDVQK WLSSPFPSSS FSPGGLAPEI SPLEVLERDK VTQLLLQQDK       240
VPEPASLSSN HSLTSCFTNQ GYFFFHLPDA LEIEACQVYF TYDPYSEEDP DEGVAGAPTG       300
SSPQPLQPLS GEDDAYCTFP SRDDLLLFSP SLLGGPSPPS TAPGGSGAGE ERMPPSLQER       360
VPRDWDPQPL GPPTPGVPDL VDFQPPPELV LREAGEEVPD AGPREGVSFP WSRPPGQGEF       420
RALNARLPLN TDAYLSLQEL QGQDPTHLV                                         449

<210> 26
<211> 489
<212> PRT
<213> Artificial Sequence
<221> DICCRE-15A amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PNCRNTGPWL KKVLKCNTPD PSKFFSQLSS EHGGDVQKWL        60
SSPFPSSSFS PGGLAPEISP LEVLERDKVT QLLLQQDKVP EPASLSSNHS LTSCFTNQGY       120
FFFHLPDALE IEACQVYFTY DPYSEEDERT MPRIPTLKNL EDLVTEYHGN FSAWSGVSKG       180
LAESLQPDYS ERLCLVSEIP PKGGALGEGP GASPCNQHSP YWAPPCYTLK PETPLNTDAY       240
LSLQELQGQD PTHLVGGGGS GGGGSGVQVE TISPGDGRTF PKRGQTCVVH YTGMLEDGKK       300
VDSSRDRNKP FKFMLGKQEV IRGWEEGVAQ MSVGQRAKLT ISPDYAYGAT GHPGIIPPHA       360
TLVFDVELLK LEGGGGSGGG GSGVQVETIS PGDGRTFPKR GQTCVVHYTG MLEDGKKVDS       420
SRDRNKPFKF MLGKQEVIRG WEEGVAQMSV GQRAKLTISP DYAYGATGHP GIIPPHATLV       480
FDVELLKLE                                                               489

<210> 27
<211> 561
<212> PRT
<213> Artificial Sequence
<221> DICCRE-7A amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PPILLTISIL SFFSVALLVI LACVLWKKRI KPIVWPSLPD        60
HKKTLEHLCK KPRKNLNVSF NPESFLDCQI HRVDDIQARD EVEGFLQDTF PQQLEESEKQ       120
RLGGDVQSPN CPSEDVVITP ESFGRDSSLT CLAGNVSACD APILSSSRSL DCRESGKNGP       180
HVYQDLLLSL GTTNSTLPPP FSLQSGILTL NPVAQGQPIE RTMPRIPTLK NLEDLVTEYH       240
GNFSAWSGVS KGLAESLQPD YSERLCLVSE IPPKGGALGE GPGASPCNQH SPYWAPPCYT       300
LKPETLTSLG SNQEEAYVTM SSFYQNQGGG GSGGGGSGVQ VETISPGDGR TFPKRGQTCV       360
VHYTGMLEDG KKVDSSRDRN KPFKFMLGKQ EVIRGWEEGV AQMSVGQRAK LTISPDYAYG       420
ATGHPGIIPP HATLVFDVEL LKLEGGGGSG GGGSGVQVET ISPGDGRTFP KRGQTCVVHY       480
TGMLEDGKKV DSSRDRNKPF KFMLGKQEVI RGWEEGVAQM SVGQRAKLTI SPDYAYGATG       540
HPGIIPPHAT LVFDVELLKL E                                                 561

<201> 28
<211> 625
<212> PRT
<213> Artificial Sequence
<221> DICCRE-21A amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR SLKTHPLWRL WKKIWAVPSP ERFFMPLYKG CSGDFKKWVG        60
APFTGSSLEL GPWSPEVPST LEVYSCHPPR SPAKRLQLTE LQEPAELVES DGVPKPSFWP       120
TAQNSGGSAY SEERDRPYGL VSIDTVTVLD AEGPCTWPCS CEDDGYPALD LDAGLEPSPG       180
LEDPLLDAGT TVLSCGCVSA GSPGLGGPLG SLLDRLKPPL ADGEDWAGGL PWGGRSPGGV       240
SESEAGSPLA GLDMDTFDSG FVGSDCSSPV ECDFTSPGDE GPPERTMPRI PTLKNLEDLV       300
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP       360
PCYTLKPETR SYLRQWVVIP PPLSSPGPQA SGGGGSGGGG SGVQVETISP GDGRTFPKRG       420
QTCVVHYTGM LEDGKKVDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD       480
YAYGATGHPG IIPPHATLVF DVELLKLEGG GGSGGGGSGV QVETISPGDG RTFPKRGQTC       540
VVHYTGMLED GKKVDSSRDR NKPFKFMLGK QEVIRGWEEG VAQMSVGQRA KLTISPDYAY       600
GATGHPGIIP PHATLVFDVE LLKLE                                             625

<201> 29
<211> 1127
<212> PRT
<213> Artificial Sequence
<221> CAR1-15 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWIG VIWGSETTYY NSALKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSIPWL GHLLVGLSGA FGFIILVYLL INCRNTGPWL KKVLKCNTPD PSKFFSQLSS       720
EHGGDVQKWL SSPFPSSSFS PGGLAPEISP LEVLERDKVT QLLLQQDKVP EPASLSSNHS       780
LTSCFTNQGY FFFHLPDALE IEACQVYFTY DPYSEEDPLN TDAYLSLQEL QGQDPTHLVG       840
SGATNFSLLK QAGDVEENPG PGSGEGRGSL LTCGDVEENP GPMALPVTAL LLPLALLLHA       900
ARPGVQVETI SPGDGRTFPK RGQTCVVHYT GMLEDGKKVD SSRDRNKPFK FMLGKQEVIR       960
GWEEGVAQMS VGQRAKLTIS PDYAYGATGH PGIIPPHATL VFDVELLKLE GGGGSGGGGS      1020
VVISVGSMGL IISLLCVYFW LERTMPRIPT LKNLEDLVTE YHGNFSAWSG VSKGLAESLQ      1080
PDYSERLCLV SEIPPKGGAL GEGPGASPCN QHSPYWAPPC YTLKPET                    1127

<201> 30
<211> 1174
<212> PRT
<213> Artificial Sequence
<221> CAR1-7 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWIG VIWGSETTYY NSALKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSPILL TISILSFFSV ALLVILACVL WKKRIKPIVW PSLPDHKKTL EHLCKKPRKN       720
LNVSFNPESF LDCQIHRVDD IQARDEVEGF LQDTFPQQLE ESEKQRLGGD VQSPNCPSED       780
VVITPESFGR DSSLTCLAGN VSACDAPILS SSRSLDCRES GKNGPHVYQD LLLSLGTTNS       840
TLPPPFSLQS GILTLNPVAQ GQPILTSLGS NQEEAYVTMS SFYQNQGSGA TNFSLLKQAG       900
DVEENPGPGS GEGRGSLLTC GDVEENPGPM ALPVTALLLP LALLLHAARP GVQVETISPG       960
DGRTFPKRGQ TCVVHYTGML EDGKKVDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ      1020
RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLEGGG GSGGGGSVVI SVGSMGLIIS      1080
LLCVYFWLER TMPRIPTLKN LEDLVTEYHG NFSAWSGVSK GLAESLQPDY SERLCLVSEI      1140
PPKGGALGEG PGASPCNQHS PYWAPPCYTL KPET                                  1174

<201> 31
<211> 1260
<212> PRT
<213> Artificial Sequence
<221> CAR1-21 amino acid sequence
<400>  
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWIG VIWGSETTYY NSALKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSGWNP HLLLLLLLVI VFIPAFWSLK THPLWRLWKK IWAVPSPERF FMPLYKGCSG       720
DFKKWVGAPF TGSSLELGPW SPEVPSTLEV YSCHPPRSPA KRLQLTELQE PAELVESDGV       780
PKPSFWPTAQ NSGGSAYSEE RDRPYGLVSI DTVTVLDAEG PCTWPCSCED DGYPALDLDA       840
GLEPSPGLED PLLDAGTTVL SCGCVSAGSP GLGGPLGSLL DRLKPPLADG EDWAGGLPWG       900
GRSPGGVSES EAGSPLAGLD MDTFDSGFVG SDCSSPVECD FTSPGDEGPP RSYLRQWVVI       960
PPPLSSPGPQ ASGSGATNFS LLKQAGDVEE NPGPGSGEGR GSLLTCGDVE ENPGPMALPV      1020
TALLLPLALL LHAARPGVQV ETISPGDGRT FPKRGQTCVV HYTGMLEDGK KVDSSRDRNK      1080
PFKFMLGKQE VIRGWEEGVA QMSVGQRAKL TISPDYAYGA TGHPGIIPPH ATLVFDVELL      1140
KLEGGGGSGG GGSVVISVGS MGLIISLLCV YFWLERTMPR IPTLKNLEDL VTEYHGNFSA      1200
WSGVSKGLAE SLQPDYSERL CLVSEIPPKG GALGEGPGAS PCNQHSPYWA PPCYTLKPET      1260

<201> 32
<211> 1266
<212> PRT
<213> Artificial Sequence
<221> CAR1-27 amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWIG VIWGSETTYY NSALKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSGWNP HLLLLLLLVI VFIPAFWTSG RCYHLRHKVL PRWVWEKVPD PANSSSGQPH       720
MEQVPEAQPL GDLPILEVEE MEPPPVMESS QPAQATAPLD SGYEKHFLPT PEELGLLGPP       780
RPQVLAGSGA TNFSLLKQAG DVEENPGPGS GEGRGSLLTC GDVEENPGPM ALPVTALLLP       840
LALLLHAARP GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKVDSSR DRNKPFKFML       900
GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLEGGG       960
GSGGGGSAIV VPVCLAFLLT TLLGVLFCFN KRDLIKKHIW PNVPDPSKSH IAQWSPHTPP      1020
RHNFNSKDQM YSDGNFTDVS VVEIEANDKK PFPEDLKSLD LFKKEKINTE GHSSGIGGSS      1080
CMSSSRPSIS SSDENESSQN TSSTVQYSTV VHSGYRHQVP SVQVFSRSES TQPLLDSEER      1140
PEDLQLVDHV DGGDGILPRQ QYFKQNCSQH ESSPDISHFE RSKQVSSVNE EDFVRLKQQI      1200
SDHISQSCGS GQMKMFQEVS AADAFGPGTE GQVERFETVG MEAATDEGMP KSYLPQTVRQ      1260
GGYMPQ                                                                 1266  

<201> 33
<211> 996
<212> PRT
<213> Artificial Sequence
<221> CAR1-15A amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PNCRNTGPWL KKVLKCNTPD PSKFFSQLSS EHGGDVQKWL        60
SSPFPSSSFS PGGLAPEISP LEVLERDKVT QLLLQQDKVP EPASLSSNHS LTSCFTNQGY       120
FFFHLPDALE IEACQVYFTY DPYSEEDERT MPRIPTLKNL EDLVTEYHGN FSAWSGVSKG       180
LAESLQPDYS ERLCLVSEIP PKGGALGEGP GASPCNQHSP YWAPPCYTLK PETPLNTDAY       240
LSLQELQGQD PTHLVGGGGS GGGGSGVQVE TISPGDGRTF PKRGQTCVVH YTGMLEDGKK       300
VDSSRDRNKP FKFMLGKQEV IRGWEEGVAQ MSVGQRAKLT ISPDYAYGAT GHPGIIPPHA       360
TLVFDVELLK LEGGGGSGGG GSGVQVETIS PGDGRTFPKR GQTCVVHYTG MLEDGKKVDS       420
SRDRNKPFKF MLGKQEVIRG WEEGVAQMSV GQRAKLTISP DYAYGATGHP GIIPPHATLV       480
FDVELLKLEG SGATNFSLLK QAGDVEENPG PMALPVTALL LPLALLLHAA RPQVQLQQWG       540
AGLLKPSETL SLTCAVSGVS LPDYGVSWIR QPPGKGLEWI GVIWGSETTY YNSALKSVTI       600
IKDTSKNQFF LKLSSVTAAD TAVYYCARHY YYGGSYAMDY WGQGTTVTVS SGGGGSGGGG       660
SGGGGSDIQM TQSPSSLSAS VGDRVTITCR ASQDISKYLN WYQQKPGKAP KLLIYHTSRL       720
HSGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCQQGNTL PYTFGGGTKV EIKTTTPAPR       780
PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL       840
YCKRGRKKLL YIFKQPFMRP VQTTQEEDGC SCRFPEEEEG GCELRVKFSR SADAPAYQQG       900
QNQLYNELNL GRREEYDVLD KRRGRDPEMG GKPRRKNPQE GLYNELQKDK MAEAYSEIGM       960
KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR                                 996

<201> 34
<211> 1068
<212> PRT
<213> Artificial Sequence
<221> CAR1-7A amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PPILLTISIL SFFSVALLVI LACVLWKKRI KPIVWPSLPD        60
HKKTLEHLCK KPRKNLNVSF NPESFLDCQI HRVDDIQARD EVEGFLQDTF PQQLEESEKQ       120
RLGGDVQSPN CPSEDVVITP ESFGRDSSLT CLAGNVSACD APILSSSRSL DCRESGKNGP       180
HVYQDLLLSL GTTNSTLPPP FSLQSGILTL NPVAQGQPIE RTMPRIPTLK NLEDLVTEYH       240
GNFSAWSGVS KGLAESLQPD YSERLCLVSE IPPKGGALGE GPGASPCNQH SPYWAPPCYT       300
LKPETLTSLG SNQEEAYVTM SSFYQNQGGG GSGGGGSGVQ VETISPGDGR TFPKRGQTCV       360
VHYTGMLEDG KKVDSSRDRN KPFKFMLGKQ EVIRGWEEGV AQMSVGQRAK LTISPDYAYG       420
ATGHPGIIPP HATLVFDVEL LKLEGGGGSG GGGSGVQVET ISPGDGRTFP KRGQTCVVHY       480
TGMLEDGKKV DSSRDRNKPF KFMLGKQEVI RGWEEGVAQM SVGQRAKLTI SPDYAYGATG       540
HPGIIPPHAT LVFDVELLKL EGSGATNFSL LKQAGDVEEN PGPMALPVTA LLLPLALLLH       600
AARPQVQLQQ WGAGLLKPSE TLSLTCAVSG VSLPDYGVSW IRQPPGKGLE WIGVIWGSET       660
TYYNSALKSV TIIKDTSKNQ FFLKLSSVTA ADTAVYYCAR HYYYGGSYAM DYWGQGTTVT       720
VSSGGGGSGG GGSGGGGSDI QMTQSPSSLS ASVGDRVTIT CRASQDISKY LNWYQQKPGK       780
APKLLIYHTS RLHSGVPSRF SGSGSGTDFT FTISSLQPED IATYYCQQGN TLPYTFGGGT       840
KVEIKTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT       900
CGVLLLSLVI TLYCKRGRKK LLYIFKQPFM RPVQTTQEED GCSCRFPEEE EGGCELRVKF       960
SRSADAPAYQ QGQNQLYNEL NLGRREEYDV LDKRRGRDPE MGGKPRRKNP QEGLYNELQK      1020
DKMAEAYSEI GMKGERRRGK GHDGLYQGLS TATKDTYDAL HMQALPPR                   1068

<201> 35
<211> 1132
<212> PRT
<213> Artificial Sequence
<221> CAR1-21A amino acid sequence
<400>
MALPVTALLL PLALLLHAAR SLKTHPLWRL WKKIWAVPSP ERFFMPLYKG CSGDFKKWVG        60
APFTGSSLEL GPWSPEVPST LEVYSCHPPR SPAKRLQLTE LQEPAELVES DGVPKPSFWP       120
TAQNSGGSAY SEERDRPYGL VSIDTVTVLD AEGPCTWPCS CEDDGYPALD LDAGLEPSPG       180
LEDPLLDAGT TVLSCGCVSA GSPGLGGPLG SLLDRLKPPL ADGEDWAGGL PWGGRSPGGV       240
SESEAGSPLA GLDMDTFDSG FVGSDCSSPV ECDFTSPGDE GPPERTMPRI PTLKNLEDLV       300
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP       360
PCYTLKPETR SYLRQWVVIP PPLSSPGPQA SGGGGSGGGG SGVQVETISP GDGRTFPKRG       420
QTCVVHYTGM LEDGKKVDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD       480
YAYGATGHPG IIPPHATLVF DVELLKLEGG GGSGGGGSGV QVETISPGDG RTFPKRGQTC       540
VVHYTGMLED GKKVDSSRDR NKPFKFMLGK QEVIRGWEEG VAQMSVGQRA KLTISPDYAY       600
GATGHPGIIP PHATLVFDVE LLKLEGSGAT NFSLLKQAGD VEENPGPMAL PVTALLLPLA       660
LLLHAARPQV QLQQWGAGLL KPSETLSLTC AVSGVSLPDY GVSWIRQPPG KGLEWIGVIW       720
GSETTYYNSA LKSVTIIKDT SKNQFFLKLS SVTAADTAVY YCARHYYYGG SYAMDYWGQG       780
TTVTVSSGGG GSGGGGSGGG GSDIQMTQSP SSLSASVGDR VTITCRASQD ISKYLNWYQQ       840
KPGKAPKLLI YHTSRLHSGV PSRFSGSGSG TDFTFTISSL QPEDIATYYC QQGNTLPYTF       900
GGGTKVEIKT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP       960
LAGTCGVLLL SLVITLYCKR GRKKLLYIFK QPFMRPVQTT QEEDGCSCRF PEEEEGGCEL      1020
RVKFSRSADA PAYQQGQNQL YNELNLGRRE EYDVLDKRRG RDPEMGGKPR RKNPQEGLYN      1080
ELQKDKMAEA YSEIGMKGER RRGKGHDGLY QGLSTATKDT YDALHMQALP PR              1132

<201> 36
<211> 1127
<212> PRT
<213> Artificial Sequence
<221> CAR2-15 amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWLG VIWGSETTYY SSSLKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSIPWL GHLLVGLSGA FGFIILVYLL INCRNTGPWL KKVLKCNTPD PSKFFSQLSS       720
EHGGDVQKWL SSPFPSSSFS PGGLAPEISP LEVLERDKVT QLLLQQDKVP EPASLSSNHS       780
LTSCFTNQGY FFFHLPDALE IEACQVYFTY DPYSEEDPLN TDAYLSLQEL QGQDPTHLVG       840
SGATNFSLLK QAGDVEENPG PGSGEGRGSL LTCGDVEENP GPMALPVTAL LLPLALLLHA       900
ARPGVQVETI SPGDGRTFPK RGQTCVVHYT GMLEDGKKVD SSRDRNKPFK FMLGKQEVIR       960
GWEEGVAQMS VGQRAKLTIS PDYAYGATGH PGIIPPHATL VFDVELLKLE GGGGSGGGGS      1020
VVISVGSMGL IISLLCVYFW LERTMPRIPT LKNLEDLVTE YHGNFSAWSG VSKGLAESLQ      1080
PDYSERLCLV SEIPPKGGAL GEGPGASPCN QHSPYWAPPC YTLKPET                    1127

<201> 37
<211> 1174
<212> PRT
<213> Artificial Sequence
<221> CAR2-7 amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWLG VIWGSETTYY SSSLKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSPILL TISILSFFSV ALLVILACVL WKKRIKPIVW PSLPDHKKTL EHLCKKPRKN       720
LNVSFNPESF LDCQIHRVDD IQARDEVEGF LQDTFPQQLE ESEKQRLGGD VQSPNCPSED       780
VVITPESFGR DSSLTCLAGN VSACDAPILS SSRSLDCRES GKNGPHVYQD LLLSLGTTNS       840
TLPPPFSLQS GILTLNPVAQ GQPILTSLGS NQEEAYVTMS SFYQNQGSGA TNFSLLKQAG       900
DVEENPGPGS GEGRGSLLTC GDVEENPGPM ALPVTALLLP LALLLHAARP GVQVETISPG       960
DGRTFPKRGQ TCVVHYTGML EDGKKVDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ      1020
RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLEGGG GSGGGGSVVI SVGSMGLIIS      1080
LLCVYFWLER TMPRIPTLKN LEDLVTEYHG NFSAWSGVSK GLAESLQPDY SERLCLVSEI      1140
PPKGGALGEG PGASPCNQHS PYWAPPCYTL KPET                                  1174

<201> 38
<211> 1260
<212> PRT
<213> Artificial Sequence
<221> CAR2-21 amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWLG VIWGSETTYY SSSLKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSGWNP HLLLLLLLVI VFIPAFWSLK THPLWRLWKK IWAVPSPERF FMPLYKGCSG       720
DFKKWVGAPF TGSSLELGPW SPEVPSTLEV YSCHPPRSPA KRLQLTELQE PAELVESDGV       780
PKPSFWPTAQ NSGGSAYSEE RDRPYGLVSI DTVTVLDAEG PCTWPCSCED DGYPALDLDA       840
GLEPSPGLED PLLDAGTTVL SCGCVSAGSP GLGGPLGSLL DRLKPPLADG EDWAGGLPWG       900
GRSPGGVSES EAGSPLAGLD MDTFDSGFVG SDCSSPVECD FTSPGDEGPP RSYLRQWVVI       960
PPPLSSPGPQ ASGSGATNFS LLKQAGDVEE NPGPGSGEGR GSLLTCGDVE ENPGPMALPV      1020
TALLLPLALL LHAARPGVQV ETISPGDGRT FPKRGQTCVV HYTGMLEDGK KVDSSRDRNK      1080
PFKFMLGKQE VIRGWEEGVA QMSVGQRAKL TISPDYAYGA TGHPGIIPPH ATLVFDVELL      1140
KLEGGGGSGG GGSVVISVGS MGLIISLLCV YFWLERTMPR IPTLKNLEDL VTEYHGNFSA      1200
WSGVSKGLAE SLQPDYSERL CLVSEIPPKG GALGEGPGAS PCNQHSPYWA PPCYTLKPET      1260

<201> 39
<211> 1266
<212> PRT
<213> Artificial Sequence
<221> CAR2-27 amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PQVQLQQWGA GLLKPSETLS LTCAVSGVSL PDYGVSWIRQ        60
PPGKGLEWLG VIWGSETTYY SSSLKSVTII KDTSKNQFFL KLSSVTAADT AVYYCARHYY       120
YGGSYAMDYW GQGTTVTVSS GGGGSGGGGS GGGGSDIQMT QSPSSLSASV GDRVTITCRA       180
SQDISKYLNW YQQKPGKAPK LLIYHTSRLH SGVPSRFSGS GSGTDFTFTI SSLQPEDIAT       240
YYCQQGNTLP YTFGGGTKVE IKTTTPAPRP PTPAPTIASQ PLSLRPEACR PAAGGAVHTR       300
GLDFACDIYI WAPLAGTCGV LLLSLVITLY CKRGRKKLLY IFKQPFMRPV QTTQEEDGCS       360
CRFPEEEEGG CELRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG       420
KPRRKNPQEG LYNELQKDKM AEAYSEIGMK GERRRGKGHD GLYQGLSTAT KDTYDALHMQ       480
ALPPRGSGAT NFSLLKQAGD VEENPGPGSG EGRGSLLTCG DVEENPGPMA LPVTALLLPL       540
ALLLHAARPG VQVETISPGD GRTFPKRGQT CVVHYTGMLE DGKKVDSSRD RNKPFKFMLG       600
KQEVIRGWEE GVAQMSVGQR AKLTISPDYA YGATGHPGII PPHATLVFDV ELLKLEGGGG       660
SGGGGSGWNP HLLLLLLLVI VFIPAFWTSG RCYHLRHKVL PRWVWEKVPD PANSSSGQPH       720
MEQVPEAQPL GDLPILEVEE MEPPPVMESS QPAQATAPLD SGYEKHFLPT PEELGLLGPP       780
RPQVLAGSGA TNFSLLKQAG DVEENPGPGS GEGRGSLLTC GDVEENPGPM ALPVTALLLP       840
LALLLHAARP GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKVDSSR DRNKPFKFML       900
GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLEGGG       960
GSGGGGSAIV VPVCLAFLLT TLLGVLFCFN KRDLIKKHIW PNVPDPSKSH IAQWSPHTPP      1020
RHNFNSKDQM YSDGNFTDVS VVEIEANDKK PFPEDLKSLD LFKKEKINTE GHSSGIGGSS      1080
CMSSSRPSIS SSDENESSQN TSSTVQYSTV VHSGYRHQVP SVQVFSRSES TQPLLDSEER      1140
PEDLQLVDHV DGGDGILPRQ QYFKQNCSQH ESSPDISHFE RSKQVSSVNE EDFVRLKQQI      1200
SDHISQSCGS GQMKMFQEVS AADAFGPGTE GQVERFETVG MEAATDEGMP KSYLPQTVRQ      1260
GGYMPQ                                                                 1266

<201> 40
<211> 996
<212> PRT
<213> Artificial Sequence
<221> CAR2-15A amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PNCRNTGPWL KKVLKCNTPD PSKFFSQLSS EHGGDVQKWL        60
SSPFPSSSFS PGGLAPEISP LEVLERDKVT QLLLQQDKVP EPASLSSNHS LTSCFTNQGY       120
FFFHLPDALE IEACQVYFTY DPYSEEDERT MPRIPTLKNL EDLVTEYHGN FSAWSGVSKG       180
LAESLQPDYS ERLCLVSEIP PKGGALGEGP GASPCNQHSP YWAPPCYTLK PETPLNTDAY       240
LSLQELQGQD PTHLVGGGGS GGGGSGVQVE TISPGDGRTF PKRGQTCVVH YTGMLEDGKK       300
VDSSRDRNKP FKFMLGKQEV IRGWEEGVAQ MSVGQRAKLT ISPDYAYGAT GHPGIIPPHA       360
TLVFDVELLK LEGGGGSGGG GSGVQVETIS PGDGRTFPKR GQTCVVHYTG MLEDGKKVDS       420
SRDRNKPFKF MLGKQEVIRG WEEGVAQMSV GQRAKLTISP DYAYGATGHP GIIPPHATLV       480
FDVELLKLEG SGATNFSLLK QAGDVEENPG PMALPVTALL LPLALLLHAA RPQVQLQQWG       540
AGLLKPSETL SLTCAVSGVS LPDYGVSWIR QPPGKGLEWL GVIWGSETTY YSSSLKSVTI       600
IKDTSKNQFF LKLSSVTAAD TAVYYCARHY YYGGSYAMDY WGQGTTVTVS SGGGGSGGGG       660
SGGGGSDIQM TQSPSSLSAS VGDRVTITCR ASQDISKYLN WYQQKPGKAP KLLIYHTSRL       720
HSGVPSRFSG SGSGTDFTFT ISSLQPEDIA TYYCQQGNTL PYTFGGGTKV EIKTTTPAPR       780
PPTPAPTIAS QPLSLRPEAC RPAAGGAVHT RGLDFACDIY IWAPLAGTCG VLLLSLVITL       840
YCKRGRKKLL YIFKQPFMRP VQTTQEEDGC SCRFPEEEEG GCELRVKFSR SADAPAYQQG       900
QNQLYNELNL GRREEYDVLD KRRGRDPEMG GKPRRKNPQE GLYNELQKDK MAEAYSEIGM       960
KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR                                 996

<201> 41
<211> 1068
<212> PRT
<213> Artificial Sequence
<221> CAR2-7A amino acid sequence
<400>
MALPVTALLL PLALLLHAAR PPILLTISIL SFFSVALLVI LACVLWKKRI KPIVWPSLPD        60
HKKTLEHLCK KPRKNLNVSF NPESFLDCQI HRVDDIQARD EVEGFLQDTF PQQLEESEKQ       120
RLGGDVQSPN CPSEDVVITP ESFGRDSSLT CLAGNVSACD APILSSSRSL DCRESGKNGP       180
HVYQDLLLSL GTTNSTLPPP FSLQSGILTL NPVAQGQPIE RTMPRIPTLK NLEDLVTEYH       240
GNFSAWSGVS KGLAESLQPD YSERLCLVSE IPPKGGALGE GPGASPCNQH SPYWAPPCYT       300
LKPETLTSLG SNQEEAYVTM SSFYQNQGGG GSGGGGSGVQ VETISPGDGR TFPKRGQTCV       360
VHYTGMLEDG KKVDSSRDRN KPFKFMLGKQ EVIRGWEEGV AQMSVGQRAK LTISPDYAYG       420
ATGHPGIIPP HATLVFDVEL LKLEGGGGSG GGGSGVQVET ISPGDGRTFP KRGQTCVVHY       480
TGMLEDGKKV DSSRDRNKPF KFMLGKQEVI RGWEEGVAQM SVGQRAKLTI SPDYAYGATG       540
HPGIIPPHAT LVFDVELLKL EGSGATNFSL LKQAGDVEEN PGPMALPVTA LLLPLALLLH       600
AARPQVQLQQ WGAGLLKPSE TLSLTCAVSG VSLPDYGVSW IRQPPGKGLE WLGVIWGSET       660
TYYSSSLKSV TIIKDTSKNQ FFLKLSSVTA ADTAVYYCAR HYYYGGSYAM DYWGQGTTVT       720
VSSGGGGSGG GGSGGGGSDI QMTQSPSSLS ASVGDRVTIT CRASQDISKY LNWYQQKPGK       780
APKLLIYHTS RLHSGVPSRF SGSGSGTDFT FTISSLQPED IATYYCQQGN TLPYTFGGGT       840
KVEIKTTTPA PRPPTPAPTI ASQPLSLRPE ACRPAAGGAV HTRGLDFACD IYIWAPLAGT       900
CGVLLLSLVI TLYCKRGRKK LLYIFKQPFM RPVQTTQEED GCSCRFPEEE EGGCELRVKF       960
SRSADAPAYQ QGQNQLYNEL NLGRREEYDV LDKRRGRDPE MGGKPRRKNP QEGLYNELQK      1020
DKMAEAYSEI GMKGERRRGK GHDGLYQGLS TATKDTYDAL HMQALPPR                   1068

<201> 42
<211> 1132
<212> PRT
<213> Artificial Sequence
<221> CAR2-21A amino acid sequence
<400>
MALPVTALLL PLALLLHAAR SLKTHPLWRL WKKIWAVPSP ERFFMPLYKG CSGDFKKWVG        60
APFTGSSLEL GPWSPEVPST LEVYSCHPPR SPAKRLQLTE LQEPAELVES DGVPKPSFWP       120
TAQNSGGSAY SEERDRPYGL VSIDTVTVLD AEGPCTWPCS CEDDGYPALD LDAGLEPSPG       180
LEDPLLDAGT TVLSCGCVSA GSPGLGGPLG SLLDRLKPPL ADGEDWAGGL PWGGRSPGGV       240
SESEAGSPLA GLDMDTFDSG FVGSDCSSPV ECDFTSPGDE GPPERTMPRI PTLKNLEDLV       300
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP       360
PCYTLKPETR SYLRQWVVIP PPLSSPGPQA SGGGGSGGGG SGVQVETISP GDGRTFPKRG       420
QTCVVHYTGM LEDGKKVDSS RDRNKPFKFM LGKQEVIRGW EEGVAQMSVG QRAKLTISPD       480
YAYGATGHPG IIPPHATLVF DVELLKLEGG GGSGGGGSGV QVETISPGDG RTFPKRGQTC       540
VVHYTGMLED GKKVDSSRDR NKPFKFMLGK QEVIRGWEEG VAQMSVGQRA KLTISPDYAY       600
GATGHPGIIP PHATLVFDVE LLKLEGSGAT NFSLLKQAGD VEENPGPMAL PVTALLLPLA       660
LLLHAARPQV QLQQWGAGLL KPSETLSLTC AVSGVSLPDY GVSWIRQPPG KGLEWLGVIW       720
GSETTYYSSS LKSVTIIKDT SKNQFFLKLS SVTAADTAVY YCARHYYYGG SYAMDYWGQG       780
TTVTVSSGGG GSGGGGSGGG GSDIQMTQSP SSLSASVGDR VTITCRASQD ISKYLNWYQQ       840
KPGKAPKLLI YHTSRLHSGV PSRFSGSGSG TDFTFTISSL QPEDIATYYC QQGNTLPYTF       900
GGGTKVEIKT TTPAPRPPTP APTIASQPLS LRPEACRPAA GGAVHTRGLD FACDIYIWAP       960
LAGTCGVLLL SLVITLYCKR GRKKLLYIFK QPFMRPVQTT QEEDGCSCRF PEEEEGGCEL      1020
RVKFSRSADA PAYQQGQNQL YNELNLGRRE EYDVLDKRRG RDPEMGGKPR RKNPQEGLYN      1080
ELQKDKMAEA YSEIGMKGER RRGKGHDGLY QGLSTATKDT YDALHMQALP PR              1132

<201> 43
<211> 1467
<212> DNA
<213> Artificial Sequence
<221> DICCRE-15A nucleic acid sequence
<400>
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgccaga        60
cctaactgca gaaacacagg cccctggctg aagaaagtgc tgaagtgcaa cacccctgat       120
cctagcaagt tctttagcca gctgtctagc gaacacggcg gcgacgttca gaaatggctg       180
agcagcccat ttcctagcag cagcttttct cctggcggac tggcccctga gattagccct       240
ctggaagtgc tggaacggga caaagtgact cagctgctcc tgcagcagga taaggtgcca       300
gaacctgcca gcctgagcag caatcacagc ctgaccagct gctttaccaa ccagggctac       360
ttcttcttcc atctgcctga cgctctggaa atcgaggcct gccaggtgta cttcacctac       420
gatccctaca gcgaagagga cgagcggacc atgcctagaa tccccacact gaagaacctg       480
gaagatctgg tcaccgagta ccacggcaac ttttctgctt ggagcggcgt gtccaaaggc       540
ctggcagaaa gcctgcagcc tgactactct gagagactgt gcctggtgtc tgagatccct       600
cctaaaggcg gagcccttgg agaaggacct ggcgcctctc catgtaacca gcactctcca       660
tattgggccc ctccatgcta caccctgaag cctgagacac ctctgaacac cgatgcctac       720
ctgagcctgc aagagctgca gggccaagat cctacacatc tcgttggagg cggaggatct       780
ggcggaggtg gaagcggagt gcaggttgaa acaattagcc ctggcgacgg ccggaccttt       840
cctaaaagag gacagacctg cgtcgtgcac tacaccggca tgctggaaga tggcaagaag       900
gtggacagca gccgggacag aaacaagccc ttcaagttca tgctgggcaa gcaagaagtg       960
atcagaggct gggaagaggg cgtcgcccag atgtctgttg gacagagagc caagctgaca      1020
atcagccccg attacgccta tggcgccaca ggacaccctg gaatcattcc tccacacgcc      1080
acactggtgt tcgacgtgga actgctgaaa ctggaaggtg gcggaggaag cggcggaggc      1140
ggatcaggtg ttcaggtgga aactatttct cccggcgacg gcagaacatt ccctaagagg      1200
ggtcaaacat gtgtggtcca ctatacaggc atgctcgagg acggaaaaaa agtggacagc      1260
tccagagatc ggaacaagcc gtttaagttt atgctcggaa aacaagaagt cattcgcggc      1320
tgggaagagg gtgttgctca aatgagcgtg ggccagcgcg ccaaactgac catctctcct      1380
gattatgcct acggcgctac cggccatcct ggcattattc cacctcatgc taccctggtg      1440
tttgatgtcg agctgctcaa gttggaa                                          1467

<201> 44
<211> 3402
<212> DNA
<213> Artificial Sequence
<221> CAR1-15 nucleic acid sequence
<400>
tctagaatgg ccctgcctgt gacagctctg ctgctgcctc ttgctctgct tctgcatgct        60
gctagacctc aggttcagct gcagcaatgg ggagccggac tgctgaagcc ttctgagaca       120
ctgtctctga cctgtgccgt cagcggagtg tctctgcctg attacggcgt gtcctggatc       180
agacagcctc ctggcaaagg cctggaatgg atcggagtga tctggggcag cgagacaacc       240
tactacaaca gcgccctgaa gtccgtgacc atcatcaagg acaccagcaa gaaccagttc       300
ttcctgaagc tgagcagcgt gacagccgcc gatacagccg tgtactactg cgccagacac       360
tactactacg gcggcagcta cgccatggat tattggggcc agggcaccac agtgacagtt       420
tctagcggag gcggaggaag tggtggcgga ggttctggcg gcggaggatc tgatattcag       480
atgacacaga gccccagcag cctgtctgcc tctgtgggcg atagagtgac cattacctgt       540
cgggccagcc aggacatctc caagtacctg aactggtatc agcagaagcc cggcaaggcc       600
cctaagctgc tgatctacca cacaagcaga ctgcacagcg gcgtgccaag cagattttct       660
ggcagcggct ctggcaccga cttcaccttc accatttcta gcctgcagcc tgaggacatt       720
gccacctact actgccagca gggcaacacc ctgccttaca catttggcgg aggcaccaag       780
gtggaaatca agaccaccac accagctcct cggcctccaa ctcctgctcc tacaattgcc       840
tctcagcctc tgagcctgag gcctgaagct tgtagacctg ctgctggcgg agccgtgcat       900
accagaggac tggattttgc ctgcgacatc tacatctggg cccctctggc tggaacatgt       960
ggcgtgctgc tgctgagcct ggtcatcacc ctgtactgca agcggggcag aaagaagctg      1020
ctgtacatct tcaagcagcc cttcatgcgg cccgtgcaga caacacaaga ggaagatggc      1080
tgctcctgca gattccccga ggaagaagaa ggcggctgcg agctgagagt gaagttctcc      1140
agatctgccg acgctcctgc ctatcagcag ggccagaatc agctgtacaa cgagctgaat      1200
ctggggcgca gagaagagta cgacgtgctg gacaagagaa ggggcagaga tcctgagatg      1260
ggcggcaagc ccagacggaa gaatcctcaa gagggcctgt ataatgagct gcagaaagac      1320
aagatggccg aggcctacag cgagatcgga atgaagggcg aacgcagaag aggcaagggc      1380
cacgatggac tgtatcaggg cctgagcaca gccaccaagg atacctatga tgccctgcac      1440
atgcaggccc tgccacctag aggatctggc gccacaaatt tcagcctgct gaaacaggcc      1500
ggcgacgtgg aagaaaatcc tggacctgga agcggcgaag gcagaggctc tttgctgaca      1560
tgcggagatg tggaagagaa ccccggacct atggctctgc cagttactgc actgctgctt      1620
ccactggcat tgctgcttca tgccgcaaga cctggcgtgc aggtcgagac aatttctcct      1680
ggcgacggcc ggacatttcc taagagagga cagacctgcg tcgtgcacta caccggcatg      1740
ctggaagatg gaaagaaggt ggacagcagc cgggacagaa acaagccctt caagttcatg      1800
ctgggcaagc aagaagtgat tagaggctgg gaagagggcg tcgcccaaat gtctgtggga      1860
cagagagcca agctgacaat cagcccagat tacgcctacg gcgccacagg acaccctgga      1920
attattcctc cacacgccac actggtgttc gatgtggaac tgctcaaact ggaaggtggc      1980
ggtggtagtg gcggtggcgg atctattcct tggctgggac atctgctcgt gggactgagc      2040
ggagccttcg gctttatcat cctggtgtac ctgctgatca actgccggaa cacaggcccc      2100
tggctgaaga aagtgctgaa gtgcaacacc cctgatccta gcaagttctt tagccagctg      2160
tctagcgagc acggcgggga tgttcagaaa tggctcagct ctccatttcc tagctccagc      2220
tttagccctg gcggactggc ccctgagatt tctccactgg aagtgctgga acgggacaaa      2280
gtgacacagc tgctgctcca gcaggataag gtgccagaac cagccagcct gagcagcaat      2340
cacagcctga ccagctgctt taccaaccag ggctacttct tctttcatct gcccgacgca      2400
ctggaaatcg aggcctgcca ggtgtacttc acctacgatc cttacagcga agaggaccct      2460
ctgaacaccg atgcctacct gagcctgcaa gagctgcagg gccaagatcc tacacacctt      2520
gttggctccg gcgctaccaa ctttagcttg ttgaagcagg ccggggatgt cgaggaaaac      2580
ccaggacctg gctctggcga aggacgggga tctcttctga cttgtgggga cgtcgaagag      2640
aatccaggtc caatggcact cccagtgact gcccttcttt tgcctctggc acttctgctg      2700
cacgcagcca gaccaggtgt ccaggtggaa actattagcc caggcgacgg cagaaccttt      2760
ccaaagcggg gacagacatg tgtggtgcat tatactggaa tgctcgagga cggcaagaaa      2820
gtggactcct ccagagatcg caacaagccg tttaagttta tgctcggaaa acaagaagtc      2880
atacgcggct gggaagaggg tgtcgctcag atgagtgttg gccagcgggc caaactgacc      2940
atctctcccg attatgccta tggcgctacc ggccatcctg gcatcattcc acctcatgct      3000
accctggtgt ttgacgtcga gcttctgaaa ttggaaggcg gaggtggaag cggaggcggc      3060
ggatctgttg tgatttctgt gggcagcatg ggcctgatca tctccctgct gtgcgtgtac      3120
ttttggctgg aaagaaccat gcctcgcatc cccacactga agaacctgga agatctggtc      3180
accgagtacc acggcaactt ttctgcttgg agcggggtgt ccaaaggact ggctgaatcc      3240
ctgcagccag attactctga gcggctgtgc ctggtgtctg agatccctcc taaaggcgga      3300
gcccttggag aaggaccagg cgcctctcca tgtaaccagc actctccata ttgggcccca      3360
ccttgctaca ccctgaagcc agagacatga ggatccgata tc                         3402

<201> 45
<211> 2997
<212> DNA
<213> Artificial Sequence
<221> CAR1-15A nucleic acid sequence
<400>
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgccaga        60
cctaactgca gaaacacagg cccctggctg aagaaagtgc tgaagtgcaa cacccctgat       120
cctagcaagt tctttagcca gctgtctagc gaacacggcg gcgacgttca gaaatggctg       180
agcagcccat ttcctagcag cagcttttct cctggcggac tggcccctga gattagccct       240
ctggaagtgc tggaacggga caaagtgact cagctgctcc tgcagcagga taaggtgcca       300
gaacctgcca gcctgagcag caatcacagc ctgaccagct gctttaccaa ccagggctac       360
ttcttcttcc atctgcctga cgctctggaa atcgaggcct gccaggtgta cttcacctac       420
gatccctaca gcgaagagga cgagcggacc atgcctagaa tccccacact gaagaacctg       480
gaagatctgg tcaccgagta ccacggcaac ttttctgctt ggagcggcgt gtccaaaggc       540
ctggcagaaa gcctgcagcc tgactactct gagagactgt gcctggtgtc tgagatccct       600
cctaaaggcg gagcccttgg agaaggacct ggcgcctctc catgtaacca gcactctcca       660
tattgggccc ctccatgcta caccctgaag cctgagacac ctctgaacac cgatgcctac       720
ctgagcctgc aagagctgca gggccaagat cctacacatc tcgttggagg cggaggatct       780
ggcggaggtg gaagcggagt gcaggttgaa acaattagcc ctggcgacgg ccggaccttt       840
cctaaaagag gacagacctg cgtcgtgcac tacaccggca tgctggaaga tggcaagaag       900
gtggacagca gccgggacag aaacaagccc ttcaagttca tgctgggcaa gcaagaagtg       960
atcagaggct gggaagaggg cgtcgcccag atgtctgttg gacagagagc caagctgaca      1020
atcagccccg attacgccta tggcgccaca ggacaccctg gaatcattcc tccacacgcc      1080
acactggtgt tcgacgtgga actgctgaaa ctggaaggtg gcggaggaag cggcggaggc      1140
ggatcaggtg ttcaggtgga aactatttct cccggcgacg gcagaacatt ccctaagagg      1200
ggtcaaacat gtgtggtcca ctatacaggc atgctcgagg acggaaaaaa agtggacagc      1260
tccagagatc ggaacaagcc gtttaagttt atgctcggaa aacaagaagt cattcgcggc      1320
tgggaagagg gtgttgctca aatgagcgtg ggccagcgcg ccaaactgac catctctcct      1380
gattatgcct acggcgctac cggccatcct ggcattattc cacctcatgc taccctggtg      1440
tttgatgtcg agctgctcaa gttggaaggc agcggcgcca caaacttcag tctgcttaaa      1500
caggccggcg acgtcgaaga gaaccctgga cctatggctc tgccagttac tgccctgctt      1560
cttcctctgg cactgctgct ccatgctgct agacctcagg ttcagctgca gcaatgggga      1620
gctggactgc tgaagcctag cgagacactg tctctgacat gtgccgtcag cggagtgtcc      1680
ctgccagatt atggcgtgtc ctggatcaga cagcctcctg gcaaaggact ggaatggatc      1740
ggcgtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc cgtgaccatc      1800
atcaaggaca ccagcaagaa ccagttcttc ctgaagctgt ccagcgtgac agccgccgat      1860
acagccgtgt actactgcgc cagacactac tactacggcg gcagctacgc catggattat      1920
tggggccagg gcaccacagt gacagtgtca agcggaggtg gtggtagcgg aggtggcggc      1980
tctggtggtg gtggatctga tatccagatg acacagagcc ctagcagcct gtctgcctct      2040
gtgggcgata gagtgaccat tacctgcaga gccagccagg acatctccaa gtacctgaac      2100
tggtatcagc agaagcccgg caaggcccct aagctgctga tctatcacac cagcagactg      2160
cacagcggcg tgcccagcag attttctggc tctggcagcg gcaccgactt caccttcacc      2220
attagttccc tgcagccaga ggatatcgcc acctactact gccagcaggg caacacactg      2280
ccttacacct ttggcggagg caccaaggtg gaaatcaaga ccacaacacc cgctcctcgg      2340
ccaccaacac cagctccaac aattgcctct cagccactga gcctgaggcc agaagcttgt      2400
agacctgctg ctggcggagc cgtgcatacc agaggactgg atttcgcctg cgacatctat      2460
atctgggccc cactggctgg aacatgtggc gtgctgctgc tgagcctggt catcaccctg      2520
tactgcaagc ggggcagaaa gaagctgctg tacatcttca agcagccctt catgcggccc      2580
gtgcagacca cacaagagga agatggttgc agctgtcggt tccccgaaga agaggaaggc      2640
ggttgcgaac tgagagtgaa gttcagcaga tccgccgacg ctcctgctta tcagcagggc      2700
cagaaccagc tgtacaacga gctgaatctg gggagaagag aagagtacga cgtgctggat      2760
aagcggagag gcagagatcc tgagatgggc ggcaagccca gacggaagaa tcctcaagag      2820
ggcctgtata atgagctgca gaaagacaag atggccgagg cctactccga gatcggcatg      2880
aagggcgagc gtagaagagg caagggccac gatggactgt accagggact gagcacagcc      2940
accaaggaca catacgatgc cctgcacatg caggccctgc cacctagata aggatcc         2997

<201> 46
<211> 10052
<212> DNA
<213> Artificial Sequence
<221> CAR1-15 vector sequence
<400>
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg        60
atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt       120
gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc       180
tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac       240
attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat       300
atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg       360
acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt       420
tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag       480
tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc       540
attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag       600
tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt       660
ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc       720
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg       780
gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct       840
ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt       900
aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac       960
tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc      1020
gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc      1080
ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa      1140
ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg      1200
ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata      1260
aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc      1320
tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga      1380
caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc      1440
aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca      1500
aaagtaagac caccgcacag caagcggccg gccgctgatc ttcagacctg gaggaggaga      1560
tatgagggac aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt      1620
aggagtagca cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg      1680
aataggagct ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc      1740
aatgacgctg acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa      1800
tttgctgagg gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa      1860
gcagctccag gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg      1920
gatttggggt tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg      1980
gagtaataaa tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga      2040
aattaacaat tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga      2100
aaagaatgaa caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa      2160
cataacaaat tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg      2220
tttaagaata gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc      2280
attatcgttt cagacccacc tcccaacccc gaggggaccc gacaggcccg aaggaataga      2340
agaagaaggt ggagagagag acagagacag atccattcga ttagtgaacg gatcggcact      2400
gcgtgcgcca attctgcaga caaatggcag tattcatcca caattttaaa agaaaagggg      2460
ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa      2520
ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca      2580
gcagagatcc agtttggtta gtaccgggcc cgctctagcg tgaggctccg gtgcccgtca      2640
gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg tcggcaattg      2700
aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg tgtactggct      2760
ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt      2820
tctttttcgc aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg gttcccgcgg      2880
gcctggcctc tttacgggtt atggcccttg cgtgccttga attacttcca cctggctgca      2940
gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg      3000
cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg      3060
ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc      3120
catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa      3180
tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc      3240
ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat      3300
cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg      3360
tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag      3420
atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga      3480
gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc      3540
atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg      3600
gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga      3660
gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc      3720
cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt      3780
tcttccattt caggtgtcgt gagcggccgc tgagttaact attctagaat ggccctgcct      3840
gtgacagctc tgctgctgcc tcttgctctg cttctgcatg ctgctagacc tcaggttcag      3900
ctgcagcaat ggggagccgg actgctgaag ccttctgaga cactgtctct gacctgtgcc      3960
gtcagcggag tgtctctgcc tgattacggc gtgtcctgga tcagacagcc tcctggcaaa      4020
ggcctggaat ggatcggagt gatctggggc agcgagacaa cctactacaa cagcgccctg      4080
aagtccgtga ccatcatcaa ggacaccagc aagaaccagt tcttcctgaa gctgagcagc      4140
gtgacagccg ccgatacagc cgtgtactac tgcgccagac actactacta cggcggcagc      4200
tacgccatgg attattgggg ccagggcacc acagtgacag tttctagcgg aggcggagga      4260
agtggtggcg gaggttctgg cggcggagga tctgatattc agatgacaca gagccccagc      4320
agcctgtctg cctctgtggg cgatagagtg accattacct gtcgggccag ccaggacatc      4380
tccaagtacc tgaactggta tcagcagaag cccggcaagg cccctaagct gctgatctac      4440
cacacaagca gactgcacag cggcgtgcca agcagatttt ctggcagcgg ctctggcacc      4500
gacttcacct tcaccatttc tagcctgcag cctgaggaca ttgccaccta ctactgccag      4560
cagggcaaca ccctgcctta cacatttggc ggaggcacca aggtggaaat caagaccacc      4620
acaccagctc ctcggcctcc aactcctgct cctacaattg cctctcagcc tctgagcctg      4680
aggcctgaag cttgtagacc tgctgctggc ggagccgtgc ataccagagg actggatttt      4740
gcctgcgaca tctacatctg ggcccctctg gctggaacat gtggcgtgct gctgctgagc      4800
ctggtcatca ccctgtactg caagcggggc agaaagaagc tgctgtacat cttcaagcag      4860
cccttcatgc ggcccgtgca gacaacacaa gaggaagatg gctgctcctg cagattcccc      4920
gaggaagaag aaggcggctg cgagctgaga gtgaagttct ccagatctgc cgacgctcct      4980
gcctatcagc agggccagaa tcagctgtac aacgagctga atctggggcg cagagaagag      5040
tacgacgtgc tggacaagag aaggggcaga gatcctgaga tgggcggcaa gcccagacgg      5100
aagaatcctc aagagggcct gtataatgag ctgcagaaag acaagatggc cgaggcctac      5160
agcgagatcg gaatgaaggg cgaacgcaga agaggcaagg gccacgatgg actgtatcag      5220
ggcctgagca cagccaccaa ggatacctat gatgccctgc acatgcaggc cctgccacct      5280
agaggatctg gcgccacaaa tttcagcctg ctgaaacagg ccggcgacgt ggaagaaaat      5340
cctggacctg gaagcggcga aggcagaggc tctttgctga catgcggaga tgtggaagag      5400
aaccccggac ctatggctct gccagttact gcactgctgc ttccactggc attgctgctt      5460
catgccgcaa gacctggcgt gcaggtcgag acaatttctc ctggcgacgg ccggacattt      5520
cctaagagag gacagacctg cgtcgtgcac tacaccggca tgctggaaga tggaaagaag      5580
gtggacagca gccgggacag aaacaagccc ttcaagttca tgctgggcaa gcaagaagtg      5640
attagaggct gggaagaggg cgtcgcccaa atgtctgtgg gacagagagc caagctgaca      5700
atcagcccag attacgccta cggcgccaca ggacaccctg gaattattcc tccacacgcc      5760
acactggtgt tcgatgtgga actgctcaaa ctggaaggtg gcggtggtag tggcggtggc      5820
ggatctattc cttggctggg acatctgctc gtgggactga gcggagcctt cggctttatc      5880
atcctggtgt acctgctgat caactgccgg aacacaggcc cctggctgaa gaaagtgctg      5940
aagtgcaaca cccctgatcc tagcaagttc tttagccagc tgtctagcga gcacggcggg      6000
gatgttcaga aatggctcag ctctccattt cctagctcca gctttagccc tggcggactg      6060
gcccctgaga tttctccact ggaagtgctg gaacgggaca aagtgacaca gctgctgctc      6120
cagcaggata aggtgccaga accagccagc ctgagcagca atcacagcct gaccagctgc      6180
tttaccaacc agggctactt cttctttcat ctgcccgacg cactggaaat cgaggcctgc      6240
caggtgtact tcacctacga tccttacagc gaagaggacc ctctgaacac cgatgcctac      6300
ctgagcctgc aagagctgca gggccaagat cctacacacc ttgttggctc cggcgctacc      6360
aactttagct tgttgaagca ggccggggat gtcgaggaaa acccaggacc tggctctggc      6420
gaaggacggg gatctcttct gacttgtggg gacgtcgaag agaatccagg tccaatggca      6480
ctcccagtga ctgcccttct tttgcctctg gcacttctgc tgcacgcagc cagaccaggt      6540
gtccaggtgg aaactattag cccaggcgac ggcagaacct ttccaaagcg gggacagaca      6600
tgtgtggtgc attatactgg aatgctcgag gacggcaaga aagtggactc ctccagagat      6660
cgcaacaagc cgtttaagtt tatgctcgga aaacaagaag tcatacgcgg ctgggaagag      6720
ggtgtcgctc agatgagtgt tggccagcgg gccaaactga ccatctctcc cgattatgcc      6780
tatggcgcta ccggccatcc tggcatcatt ccacctcatg ctaccctggt gtttgacgtc      6840
gagcttctga aattggaagg cggaggtgga agcggaggcg gcggatctgt tgtgatttct      6900
gtgggcagca tgggcctgat catctccctg ctgtgcgtgt acttttggct ggaaagaacc      6960
atgcctcgca tccccacact gaagaacctg gaagatctgg tcaccgagta ccacggcaac      7020
ttttctgctt ggagcggggt gtccaaagga ctggctgaat ccctgcagcc agattactct      7080
gagcggctgt gcctggtgtc tgagatccct cctaaaggcg gagcccttgg agaaggacca      7140
ggcgcctctc catgtaacca gcactctcca tattgggccc caccttgcta caccctgaag      7200
ccagagacat gaggatccga tatccgcccc tctccctccc ccccccctaa cgttactggc      7260
cgaagccgct tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg      7320
ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct      7380
aggggtcttt cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca      7440
gttcctctgg aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg      7500
aaccccccac ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct      7560
gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa      7620
tggctctcct caagcgtatt caacaagggg ctgaaggatg cccagaaggt acctttaaga      7680
ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa ggggggactg      7740
gaagggctaa ttcactccca acgaagacaa gatatccttg atctgtggat ctaccacaca      7800
caaggctact tccctgattg gcagaactac acaccagggc cagggatcag atatccactg      7860
acctttggat ggtgctacaa gctagtacca gttgagcaag agaaggtaga agaagccaat      7920
gaaggagaga acacccgctt gttacaccct gtgagcctgc atgggatgga tgacccggag      7980
agagaagtat tagagtggag gtttgacagc cgcctagcat ttcatcacat ggcccgagag      8040
ctgcatccgg actgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct      8100
ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta      8160
gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca      8220
gtgtggaaaa tctctagcag catgtgagca aaaggccagc aaaaggccag gaaccgtaaa      8280
aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat      8340
cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      8400
cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc      8460
gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt      8520
tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac      8580
cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg      8640
ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca      8700
gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc      8760
gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa      8820
accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa      8880
ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac      8940
tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta      9000
aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt      9060
taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata      9120
gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc      9180
agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac      9240
cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag      9300
tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac      9360
gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc      9420
agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg      9480
gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc      9540
atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct      9600
gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc      9660
tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc      9720
atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc      9780
agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc      9840
gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca      9900
cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt      9960
tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt     10020
ccgcgcacat ttccccgaaa agtgccacct ga                                   10052

<201> 47
<211> 9652
<212> DNA
<213> Artificial Sequence
<221> CAR1-15A vector sequence
<400>
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg        60
atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt       120
gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc       180
tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac       240
attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat       300
atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg       360
acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt       420
tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag       480
tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc       540
attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag       600
tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt       660
ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc       720
accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg       780
gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct       840
ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt       900
aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac       960
tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc      1020
gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc      1080
ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa      1140
ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg      1200
ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata      1260
aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc      1320
tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga      1380
caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc      1440
aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca      1500
aaagtaagac caccgcacag caagcggccg gccgctgatc ttcagacctg gaggaggaga      1560
tatgagggac aattggagaa gtgaattata taaatataaa gtagtaaaaa ttgaaccatt      1620
aggagtagca cccaccaagg caaagagaag agtggtgcag agagaaaaaa gagcagtggg      1680
aataggagct ttgttccttg ggttcttggg agcagcagga agcactatgg gcgcagcgtc      1740
aatgacgctg acggtacagg ccagacaatt attgtctggt atagtgcagc agcagaacaa      1800
tttgctgagg gctattgagg cgcaacagca tctgttgcaa ctcacagtct ggggcatcaa      1860
gcagctccag gcaagaatcc tggctgtgga aagataccta aaggatcaac agctcctggg      1920
gatttggggt tgctctggaa aactcatttg caccactgct gtgccttgga atgctagttg      1980
gagtaataaa tctctggaac agatttggaa tcacacgacc tggatggagt gggacagaga      2040
aattaacaat tacacaagct taatacactc cttaattgaa gaatcgcaaa accagcaaga      2100
aaagaatgaa caagaattat tggaattaga taaatgggca agtttgtgga attggtttaa      2160
cataacaaat tggctgtggt atataaaatt attcataatg atagtaggag gcttggtagg      2220
tttaagaata gtttttgctg tactttctat agtgaataga gttaggcagg gatattcacc      2280
attatcgttt cagacccacc tcccaacccc gaggggaccc gacaggcccg aaggaataga      2340
agaagaaggt ggagagagag acagagacag atccattcga ttagtgaacg gatcggcact      2400
gcgtgcgcca attctgcaga caaatggcag tattcatcca caattttaaa agaaaagggg      2460
ggattggggg gtacagtgca ggggaaagaa tagtagacat aatagcaaca gacatacaaa      2520
ctaaagaatt acaaaaacaa attacaaaaa ttcaaaattt tcgggtttat tacagggaca      2580
gcagagatcc agtttggtta gtaccgggcc cgctctagcg tgaggctccg gtgcccgtca      2640
gtgggcagag cgcacatcgc ccacagtccc cgagaagttg gggggagggg tcggcaattg      2700
aaccggtgcc tagagaaggt ggcgcggggt aaactgggaa agtgatgtcg tgtactggct      2760
ccgccttttt cccgagggtg ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt      2820
tctttttcgc aacgggtttg ccgccagaac acaggtaagt gccgtgtgtg gttcccgcgg      2880
gcctggcctc tttacgggtt atggcccttg cgtgccttga attacttcca cctggctgca      2940
gtacgtgatt cttgatcccg agcttcgggt tggaagtggg tgggagagtt cgaggccttg      3000
cgcttaagga gccccttcgc ctcgtgcttg agttgaggcc tggcctgggc gctggggccg      3060
ccgcgtgcga atctggtggc accttcgcgc ctgtctcgct gctttcgata agtctctagc      3120
catttaaaat ttttgatgac ctgctgcgac gctttttttc tggcaagata gtcttgtaaa      3180
tgcgggccaa gatctgcaca ctggtatttc ggtttttggg gccgcgggcg gcgacggggc      3240
ccgtgcgtcc cagcgcacat gttcggcgag gcggggcctg cgagcgcggc caccgagaat      3300
cggacggggg tagtctcaag ctggccggcc tgctctggtg cctggcctcg cgccgccgtg      3360
tatcgccccg ccctgggcgg caaggctggc ccggtcggca ccagttgcgt gagcggaaag      3420
atggccgctt cccggccctg ctgcagggag ctcaaaatgg aggacgcggc gctcgggaga      3480
gcgggcgggt gagtcaccca cacaaaggaa aagggccttt ccgtcctcag ccgtcgcttc      3540
atgtgactcc acggagtacc gggcgccgtc caggcacctc gattagttct cgagcttttg      3600
gagtacgtcg tctttaggtt ggggggaggg gttttatgcg atggagtttc cccacactga      3660
gtgggtggag actgaagtta ggccagcttg gcacttgatg taattctcct tggaatttgc      3720
cctttttgag tttggatctt ggttcattct caagcctcag acagtggttc aaagtttttt      3780
tcttccattt caggtgtcgt gagcggccgc tgagttaact attctagaat ggccctgcct      3840
gtgacagctc tgctgctgcc tcttgctctg cttctgcatg ccgccagacc taactgcaga      3900
aacacaggcc cctggctgaa gaaagtgctg aagtgcaaca cccctgatcc tagcaagttc      3960
tttagccagc tgtctagcga acacggcggc gacgttcaga aatggctgag cagcccattt      4020
cctagcagca gcttttctcc tggcggactg gcccctgaga ttagccctct ggaagtgctg      4080
gaacgggaca aagtgactca gctgctcctg cagcaggata aggtgccaga acctgccagc      4140
ctgagcagca atcacagcct gaccagctgc tttaccaacc agggctactt cttcttccat      4200
ctgcctgacg ctctggaaat cgaggcctgc caggtgtact tcacctacga tccctacagc      4260
gaagaggacg agcggaccat gcctagaatc cccacactga agaacctgga agatctggtc      4320
accgagtacc acggcaactt ttctgcttgg agcggcgtgt ccaaaggcct ggcagaaagc      4380
ctgcagcctg actactctga gagactgtgc ctggtgtctg agatccctcc taaaggcgga      4440
gcccttggag aaggacctgg cgcctctcca tgtaaccagc actctccata ttgggcccct      4500
ccatgctaca ccctgaagcc tgagacacct ctgaacaccg atgcctacct gagcctgcaa      4560
gagctgcagg gccaagatcc tacacatctc gttggaggcg gaggatctgg cggaggtgga      4620
agcggagtgc aggttgaaac aattagccct ggcgacggcc ggacctttcc taaaagagga      4680
cagacctgcg tcgtgcacta caccggcatg ctggaagatg gcaagaaggt ggacagcagc      4740
cgggacagaa acaagccctt caagttcatg ctgggcaagc aagaagtgat cagaggctgg      4800
gaagagggcg tcgcccagat gtctgttgga cagagagcca agctgacaat cagccccgat      4860
tacgcctatg gcgccacagg acaccctgga atcattcctc cacacgccac actggtgttc      4920
gacgtggaac tgctgaaact ggaaggtggc ggaggaagcg gcggaggcgg atcaggtgtt      4980
caggtggaaa ctatttctcc cggcgacggc agaacattcc ctaagagggg tcaaacatgt      5040
gtggtccact atacaggcat gctcgaggac ggaaaaaaag tggacagctc cagagatcgg      5100
aacaagccgt ttaagtttat gctcggaaaa caagaagtca ttcgcggctg ggaagagggt      5160
gttgctcaaa tgagcgtggg ccagcgcgcc aaactgacca tctctcctga ttatgcctac      5220
ggcgctaccg gccatcctgg cattattcca cctcatgcta ccctggtgtt tgatgtcgag      5280
ctgctcaagt tggaaggcag cggcgccaca aacttcagtc tgcttaaaca ggccggcgac      5340
gtcgaagaga accctggacc tatggctctg ccagttactg ccctgcttct tcctctggca      5400
ctgctgctcc atgctgctag acctcaggtt cagctgcagc aatggggagc tggactgctg      5460
aagcctagcg agacactgtc tctgacatgt gccgtcagcg gagtgtccct gccagattat      5520
ggcgtgtcct ggatcagaca gcctcctggc aaaggactgg aatggatcgg cgtgatctgg      5580
ggcagcgaga caacctacta caacagcgcc ctgaagtccg tgaccatcat caaggacacc      5640
agcaagaacc agttcttcct gaagctgtcc agcgtgacag ccgccgatac agccgtgtac      5700
tactgcgcca gacactacta ctacggcggc agctacgcca tggattattg gggccagggc      5760
accacagtga cagtgtcaag cggaggtggt ggtagcggag gtggcggctc tggtggtggt      5820
ggatctgata tccagatgac acagagccct agcagcctgt ctgcctctgt gggcgataga      5880
gtgaccatta cctgcagagc cagccaggac atctccaagt acctgaactg gtatcagcag      5940
aagcccggca aggcccctaa gctgctgatc tatcacacca gcagactgca cagcggcgtg      6000
cccagcagat tttctggctc tggcagcggc accgacttca ccttcaccat tagttccctg      6060
cagccagagg atatcgccac ctactactgc cagcagggca acacactgcc ttacaccttt      6120
ggcggaggca ccaaggtgga aatcaagacc acaacacccg ctcctcggcc accaacacca      6180
gctccaacaa ttgcctctca gccactgagc ctgaggccag aagcttgtag acctgctgct      6240
ggcggagccg tgcataccag aggactggat ttcgcctgcg acatctatat ctgggcccca      6300
ctggctggaa catgtggcgt gctgctgctg agcctggtca tcaccctgta ctgcaagcgg      6360
ggcagaaaga agctgctgta catcttcaag cagcccttca tgcggcccgt gcagaccaca      6420
caagaggaag atggttgcag ctgtcggttc cccgaagaag aggaaggcgg ttgcgaactg      6480
agagtgaagt tcagcagatc cgccgacgct cctgcttatc agcagggcca gaaccagctg      6540
tacaacgagc tgaatctggg gagaagagaa gagtacgacg tgctggataa gcggagaggc      6600
agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtataat      6660
gagctgcaga aagacaagat ggccgaggcc tactccgaga tcggcatgaa gggcgagcgt      6720
agaagaggca agggccacga tggactgtac cagggactga gcacagccac caaggacaca      6780
tacgatgccc tgcacatgca ggccctgcca cctagataag gatccgcccc tctccctccc      6840
ccccccctaa cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata      6900
tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg      6960
tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt      7020
tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag      7080
cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc      7140
cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga      7200
tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg      7260
cccagaaggt acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt      7320
taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa gatatccttg      7380
atctgtggat ctaccacaca caaggctact tccctgattg gcagaactac acaccagggc      7440
cagggatcag atatccactg acctttggat ggtgctacaa gctagtacca gttgagcaag      7500
agaaggtaga agaagccaat gaaggagaga acacccgctt gttacaccct gtgagcctgc      7560
atgggatgga tgacccggag agagaagtat tagagtggag gtttgacagc cgcctagcat      7620
ttcatcacat ggcccgagag ctgcatccgg actgtactgg gtctctctgg ttagaccaga      7680
tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct      7740
tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat      7800
ccctcagacc cttttagtca gtgtggaaaa tctctagcag catgtgagca aaaggccagc      7860
aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc      7920
ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat      7980
aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc      8040
cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct      8100
cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg      8160
aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc      8220
cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga      8280
ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa      8340
gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta      8400
gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc      8460
agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg      8520
acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga      8580
tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg      8640
agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct      8700
gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg      8760
agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc      8820
cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa      8880
ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc      8940
cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt      9000
cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc      9060
ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt      9120
tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc      9180
catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt      9240
gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata      9300
gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga      9360
tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag      9420
catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa      9480
aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt      9540
attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga      9600
aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct ga              9652

<201> 48
<211> 1179
<212> DNA
<213> Artificial Sequence
<221> EF-1a promoter nucleic acid sequence
<400>
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg        60
ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt       120
gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca       180
gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc       240
gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt       300
acttccacct ggctgcagta cgtgattctt gatcccgagc ttcgggttgg aagtgggtgg       360
gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt tgaggcctgg       420
cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg tctcgctgct       480
ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct ttttttctgg       540
caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt ttttggggcc       600
gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg gggcctgcga       660
gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc tctggtgcct       720
ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg gtcggcacca       780
gttgcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc aaaatggagg       840
acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag ggcctttccg       900
tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag gcacctcgat       960
tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt ttatgcgatg      1020
gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca cttgatgtaa      1080
ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa gcctcagaca      1140
gtggttcaaa gtttttttct tccatttcag gtgtcgtga                             1179