<110>    ABL Bio Inc.
         LEGOCHEM BIOSCIENCES, INC.

<120>    Antibody-drug conjugate comprising antibody binding to antibody
         against human ROR1, and its use

<130>    LCH-01225

<150> 	 KR 10-2019-0109807
<151>    2019-09-04

<160>    103

<170>    KopatentIn 3.0

<210>    1
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR1


<400>    1
Ser Tyr Asp Met Ser
  1               5


<210>    2
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR1


<400>    2
Asp Tyr Tyr Met Ser
  1               5


<210>    3
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR1


<400>    3
Asn Tyr Asp Met Ser
  1               5


<210>    4
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR1


<400>    4
Asn Tyr Ala Met Ser
  1               5


<210>    5
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR1


<400>    5
Asp Tyr Asp Met Ser
  1               5


<210>    6
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    6
Trp Ile Ser Pro Asp Ser Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    7
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    7
Ser Ile Ser Pro Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    8
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    8
Trp Ile Ser Pro Gly Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    9
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    9
Ala Ile Tyr His Ser Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    10
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    10
Gly Ile Ser His Gly Ser Gly Asn Lys Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    11
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    11
Ser Ile Ser His Asn Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    12
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    12
Val Ile Ser Pro Asp Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    13
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    13
Ser Ile Ser Pro Ser Ser Gly Ser Ser Ile Tyr Tyr Ala Asp Ser Val
  1               5                  10                  15 

Lys Gly
       


<210>    14
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    14
Pro Thr Gly Arg Phe Asp Tyr
  1               5        


<210>    15
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    15
Asn Leu Arg Ala Phe Asp Tyr
  1               5        


<210>    16
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    16
Val Asn Gly Arg Phe Asp Tyr
  1               5        


<210>    17
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    17
Gly Gly Asn Gly Ala Trp Asp Thr Gly Phe Asp Tyr
  1               5                  10        


<210>    18
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    18
Arg Leu Ser Leu Arg Arg Arg Pro Ser Tyr Tyr Ser Asp Asn Ala Met
  1               5                  10                  15 

Asp Val
       


<210>    19
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    19
Phe Ile Ser Ala Arg Lys Ser Leu Gly Arg Ser Tyr Ser Asn Gly Met
  1               5                  10                  15 

Asp Val
       


<210>    20
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    20
Asp Val Val Glu Cys Asn Met Asn Pro Cys Ser Tyr Asp Asn Ala Met
  1               5                  10                  15 

Asp Val
       


<210>    21
<211>    18
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    21
Ala Pro Gly Trp Cys Gln Ala Pro Ser Cys Tyr Tyr Asp Asn Ala Met
  1               5                  10                  15 

Asp Val
       


<210>    22
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    22
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Asn Val Asn
  1               5                  10            


<210>    23
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    23
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Tyr
  1               5                  10            


<210>    24
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    24
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Asn Val Ser
  1               5                  10            


<210>    25
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    25
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Asp Val Ser
  1               5                  10            


<210>    26
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    26
Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn
  1               5                  10            


<210>    27
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    27
Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn Asp Val Thr
  1               5                  10            


<210>    28
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    28
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser
  1               5                  10            


<210>    29
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR1


<400>    29
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Asp Val Ser
  1               5                  10            


<210>    30
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    30
Tyr Asp Asn Lys Arg Pro Ser
  1               5        


<210>    31
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    31
Ala Asn Ser Gln Arg Pro Ser
  1               5        


<210>    32
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    32
Ala Asp Ser His Arg Pro Ser
  1               5        


<210>    33
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    33
Tyr Asp Asn Asn Arg Pro Ser
  1               5        


<210>    34
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    34
Tyr Asp Ser Asn Arg Pro Ser
  1               5        


<210>    35
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    35
Ala Asp Ser Lys Arg Pro Ser
  1               5        


<210>    36
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    36
Asp Asp Ser His Arg Pro Ser
  1               5        


<210>    37
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR2


<400>    37
Asp Asp Ser Gln Arg Pro Ser
  1               5        


<210>    38
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR3


<400>    38
Gly Thr Trp Asp Ala Ser Leu Ser Gly Tyr Val
  1               5                  10    


<210>    39
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR3


<400>    39
Gly Ser Trp Asp Tyr Ser Leu Ser Gly Tyr Val
  1               5                  10    


<210>    40
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR3


<400>    40
Ala Thr Trp Asp Tyr Ser Leu Ser Gly Tyr Val
  1               5                  10    


<210>    41
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR3


<400>    41
Gly Ala Trp Asp Asp Ser Leu Ser Gly Tyr Val
  1               5                  10    


<210>    42
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain CDR3


<400>    42
Gly Thr Trp Asp Tyr Ser Leu Ser Gly Tyr Val
  1               5                  10    


<210>    43
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    43
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Ser Pro Asp Ser Gly Ser Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Thr Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    44
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    44
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser Pro Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asn Leu Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    45
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    45
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Ser Pro Gly Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Val Asn Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    46
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    46
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Tyr His Ser Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Gly Asn Gly Ala Trp Asp Thr Gly Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    47
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    47
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser His Gly Ser Gly Asn Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Arg Leu Ser Leu Arg Arg Arg Pro Ser Tyr Tyr Ser Asp Asn
            100                 105                 110 

Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    48
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser His Asn Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Phe Ile Ser Ala Arg Lys Ser Leu Gly Arg Ser Tyr Ser Asn
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    49
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    49
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Val Ile Ser Pro Asp Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Val Val Glu Cys Asn Met Asn Pro Cys Ser Tyr Asp Asn
            100                 105                 110 

Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    50
<211>    128
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    50
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser Pro Ser Ser Gly Ser Ser Ile Tyr Tyr Ala Asp Ser
     50                  55                  60 

Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
 65                  70                  75                  80 

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                 85                  90                  95 

Cys Ala Lys Ala Pro Gly Trp Cys Gln Ala Pro Ser Cys Tyr Tyr Asp
            100                 105                 110 

Asn Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    51
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    51
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asn Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ala Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    52
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    52
Gln Ser Val Leu Thr Gln Pro Pro Pro Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Thr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    53
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    53
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asn Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    54
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    54
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    55
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    55
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    56
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    56
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Asp Val Thr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    57
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    57
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    58
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain variable region


<400>    58
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asp Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 
 


<210>    59
<211>    446
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    59
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Ser Pro Asp Ser Gly Ser Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Thr Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125 

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175 

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190 

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
        195                 200                 205 

Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
    210                 215                 220 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255 

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            260                 265                 270 

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285 

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335 

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350 

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415 

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430 

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 
 


<210>    60
<211>    446
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser Pro Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asn Leu Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125 

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175 

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190 

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
        195                 200                 205 

Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
    210                 215                 220 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255 

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            260                 265                 270 

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285 

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335 

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350 

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415 

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430 

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 
 


<210>    61
<211>    446
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    61
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Ser Pro Gly Gly Gly Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Val Asn Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125 

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175 

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190 

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
        195                 200                 205 

Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
    210                 215                 220 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255 

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            260                 265                 270 

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285 

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335 

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350 

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415 

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430 

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 
 


<210>    62
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    62
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Tyr His Ser Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Gly Asn Gly Ala Trp Asp Thr Gly Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys
    450    


<210>    63
<211>    457
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    63
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser His Gly Ser Gly Asn Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Arg Leu Ser Leu Arg Arg Arg Pro Ser Tyr Tyr Ser Asp Asn
            100                 105                 110 

Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
        115                 120                 125 

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
    130                 135                 140 

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
145                 150                 155                 160 

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
                165                 170                 175 

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
            180                 185                 190 

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
        195                 200                 205 

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
    210                 215                 220 

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
225                 230                 235                 240 

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255 

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270 

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        275                 280                 285 

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300 

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335 

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            340                 345                 350 

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365 

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380 

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415 

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430 

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445 

Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455        


<210>    64
<211>    457
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    64
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser His Asn Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Phe Ile Ser Ala Arg Lys Ser Leu Gly Arg Ser Tyr Ser Asn
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
        115                 120                 125 

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
    130                 135                 140 

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
145                 150                 155                 160 

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
                165                 170                 175 

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
            180                 185                 190 

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
        195                 200                 205 

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
    210                 215                 220 

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
225                 230                 235                 240 

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255 

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270 

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        275                 280                 285 

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300 

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335 

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            340                 345                 350 

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365 

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380 

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415 

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430 

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445 

Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455        


<210>    65
<211>    457
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    65
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Val Ile Ser Pro Asp Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Val Val Glu Cys Asn Met Asn Pro Cys Ser Tyr Asp Asn
            100                 105                 110 

Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala
        115                 120                 125 

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
    130                 135                 140 

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
145                 150                 155                 160 

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
                165                 170                 175 

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
            180                 185                 190 

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
        195                 200                 205 

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
    210                 215                 220 

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
225                 230                 235                 240 

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255 

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270 

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        275                 280                 285 

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300 

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335 

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            340                 345                 350 

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365 

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380 

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415 

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430 

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445 

Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455        


<210>    66
<211>    458
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    66
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser Pro Ser Ser Gly Ser Ser Ile Tyr Tyr Ala Asp Ser
     50                  55                  60 

Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
 65                  70                  75                  80 

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                 85                  90                  95 

Cys Ala Lys Ala Pro Gly Trp Cys Gln Ala Pro Ser Cys Tyr Tyr Asp
            100                 105                 110 

Asn Ala Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
    130                 135                 140 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
145                 150                 155                 160 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                165                 170                 175 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
            180                 185                 190 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
        195                 200                 205 

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
    210                 215                 220 

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
225                 230                 235                 240 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                245                 250                 255 

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            260                 265                 270 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        275                 280                 285 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    290                 295                 300 

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
305                 310                 315                 320 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                325                 330                 335 

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            340                 345                 350 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
        355                 360                 365 

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    370                 375                 380 

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
385                 390                 395                 400 

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                405                 410                 415 

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            420                 425                 430 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        435                 440                 445 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455            


<210>    67
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    67
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asn Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asp Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ala Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    68
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    68
Gln Ser Val Leu Thr Gln Pro Pro Pro Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Thr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    69
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    69
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asn Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    70
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    70
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    71
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    71
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    72
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    72
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Asp Val Thr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ala Asp Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Tyr Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    73
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    73
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asp Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    74
<211>    216
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain


<400>    74
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asp Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln
            100                 105                 110 

Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu
        115                 120                 125 

Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr
    130                 135                 140 

Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys
145                 150                 155                 160 

Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr
                165                 170                 175 

Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His
            180                 185                 190 

Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys
        195                 200                 205 

Thr Val Ala Pro Ala Glu Cys Ser
    210                 215    


<210>    75
<211>    1338
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    75
gaagtacaac ttctggagtc aggtggagga cttgttcagc ccggcgggtc cctgaggctg         60

agttgcgcag caagcgggtt cacattctcc tcttatgata tgtcttgggt aagacaggct        120

cctggtaagg gtctggaatg ggtatcctgg ataagtcctg actccggttc aatatactac        180

gccgatagtg tgaagggacg tttcaccatc agccgggaca acagcaaaaa taccttgtat        240

ctccaaatga atagcctccg ggctgaagac actgccgtat attactgcgc cagacctact        300

ggtcgttttg actattgggg gcaaggaaca ctggtaaccg tttcaagcgc ctccaccaag        360

ggcccctccg tgttccccct ggccccctcc tccaagtcca cctccggcgg caccgccgcc        420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgtcctg gaactccggc        480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agtcctccgg cctgtactcc        540

ctgtcctccg tcgtgaccgt gccctcctcc tccctgggca cccagaccta catctgcaac        600

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggagcccaa gtcctgcgac        660

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggccc ctccgtgttc        720

ctgttccctc ctaagcccaa ggacaccctg atgatctccc ggacccccga ggtgacttgc        780

gtggtggtgg acgtgtccca cgaggacccc gaggtgaagt tcaactggta cgtggacggc        840

gtggaggtgc acaacgccaa gaccaagccc cgggaggagc agtacaactc cacctaccgg        900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc        960

aaggtgtcca acaaggccct gcccgccccc atcgagaaga ccatctccaa ggccaagggc       1020

cagccccggg agccccaggt gtacaccctg cccccctccc gggaggagat gaccaagaac       1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg       1140

gagtccaacg gccagcccga gaacaactac aagaccaccc cccccgtgct ggactccgac       1200

ggctccttct tcctgtactc caagctgacc gtggacaagt cccggtggca gcagggcaac       1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1320

tccctgtccc ccggcaag                                                     1338


<210>    76
<211>    1338
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    76
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggctc tctgagactg         60

tcttgcgccg cctccggctt caccttctcc gactactaca tgtcctgggt gcgacaggcc        120

cctggcaagg gcctggaatg ggtgtcctcc atctcccccg acggctccaa cacctactac        180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac        240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc caagaacctg        300

cgggccttcg actactgggg ccagggcaca ctggtgaccg tgtcctccgc ctccaccaag        360

ggcccctccg tgttccccct ggccccctcc tccaagtcca cctccggcgg caccgccgcc        420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgtcctg gaactccggc        480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agtcctccgg cctgtactcc        540

ctgtcctccg tcgtgaccgt gccctcctcc tccctgggca cccagaccta catctgcaac        600

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggagcccaa gtcctgcgac        660

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggccc ctccgtgttc        720

ctgttccctc ctaagcccaa ggacaccctg atgatctccc ggacccccga ggtgacttgc        780

gtggtggtgg acgtgtccca cgaggacccc gaggtgaagt tcaactggta cgtggacggc        840

gtggaggtgc acaacgccaa gaccaagccc cgggaggagc agtacaactc cacctaccgg        900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc        960

aaggtgtcca acaaggccct gcccgccccc atcgagaaga ccatctccaa ggccaagggc       1020

cagccccggg agccccaggt gtacaccctg cccccctccc gggaggagat gaccaagaac       1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg       1140

gagtccaacg gccagcccga gaacaactac aagaccaccc cccccgtgct ggactccgac       1200

ggctccttct tcctgtactc caagctgacc gtggacaagt cccggtggca gcagggcaac       1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1320

tccctgtccc ccggcaag                                                     1338


<210>    77
<211>    1341
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    77
gaagtgcaac ttcttgagag tggtggagga ttggtacaac ctgggggtag tttgcgtctc         60

tcctgtgctg cttctggttt cacattttcc tcctatgaca tgagctgggt acggcaagct        120

ccaggaaaag ggcttgagtg ggtctcctgg atctctcccg gtggaggcag caagtattat        180

gcagactctg taaagggtag gtttactata tcacgcgata atagtaagaa tactttgtat        240

ttgcaaatga actccctccg agctgaggac acagcagtct attattgcgc ccgagttaac        300

ggtcgcttcg attactgggg ccaaggcaca ctggttacag tgtcctcagc ctccaccaag        360

ggcccctccg tgttccccct ggccccctcc tccaagtcca cctccggcgg caccgccgcc        420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgtcctg gaactccggc        480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agtcctccgg cctgtactcc        540

ctgtcctccg tcgtgaccgt gccctcctcc tccctgggca cccagaccta catctgcaac        600

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggagcccaa gtcctgcgac        660

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggccc ctccgtgttc        720

ctgttccctc ctaagcccaa ggacaccctg atgatctccc ggacccccga ggtgacttgc        780

gtggtggtgg acgtgtccca cgaggacccc gaggtgaagt tcaactggta cgtggacggc        840

gtggaggtgc acaacgccaa gaccaagccc cgggaggagc agtacaactc cacctaccgg        900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc        960

aaggtgtcca acaaggccct gcccgccccc atcgagaaga ccatctccaa ggccaagggc       1020

cagccccggg agccccaggt gtacaccctg cccccctccc gggaggagat gaccaagaac       1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg       1140

gagtccaacg gccagcccga gaacaactac aagaccaccc cccccgtgct ggactccgac       1200

ggctccttct tcctgtactc caagctgacc gtggacaagt cccggtggca gcagggcaac       1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1320

tccctgtccc ccggcaagtg a                                                 1341


<210>    78
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    78
gaggtgcagc tgctggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcggctg         60

tcctgcgccg cctccggctt caccttctcc aactacgaca tgtcctgggt gcggcaggcc        120

cccggcaagg gcctggagtg ggtgtccgcc atctaccact ccggctcctc caagtactac        180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac        240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc ccggggcggc        300

aacggcgcct gggacaccgg cttcgactac tggggccagg gcaccctggt gaccgtgtcc        360

tccgcctcca ccaagggccc ctccgtgttc cccctggccc cctcctccaa gtccacctcc        420

ggcggcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg        480

tcctggaact ccggcgccct gacctccggc gtgcacacct tccccgccgt gctgcagtcc        540

tccggcctgt actccctgtc ctccgtcgtg accgtgccct cctcctccct gggcacccag        600

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag        660

cccaagtcct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc        720

ggcccctccg tgttcctgtt ccctcctaag cccaaggaca ccctgatgat ctcccggacc        780

cccgaggtga cttgcgtggt ggtggacgtg tcccacgagg accccgaggt gaagttcaac        840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccggga ggagcagtac        900

aactccacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc        960

aaggagtaca agtgcaaggt gtccaacaag gccctgcccg cccccatcga gaagaccatc       1020

tccaaggcca agggccagcc ccgggagccc caggtgtaca ccctgccccc ctcccgggag       1080

gagatgacca agaaccaggt gtccctgacc tgcctggtga agggcttcta cccctccgac       1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca actacaagac cacccccccc       1200

gtgctggact ccgacggctc cttcttcctg tactccaagc tgaccgtgga caagtcccgg       1260

tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactac       1320

acccagaagt ccctgtccct gtcccccggc aag                                    1353


<210>    79
<211>    1374
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    79
gaagttcaac tgttggaatc cgggggtggt ctggtccaac ctggagggtc tcttagactg         60

agttgtgctg cttcaggctt cacatttagc tcatatgata tgtcctgggt cagacaggcc        120

cccggcaaag gtcttgaatg ggtatctggt attagtcatg gatctggcaa caagtactac        180

gctgatagtg tcaaaggacg attcaccata tctcgtgaca actctaaaaa cactttgtac        240

ttgcagatga actcactgcg tgccgaagac acagccgtgt attattgcgc taagcgtctc        300

tcactccgca ggcgaccttc ctattacagc gacaacgcta tggatgtctg ggggcagggt        360

acactcgtca ccgtgtcatc agcctccacc aagggcccct ccgtgttccc cctggccccc        420

tcctccaagt ccacctccgg cggcaccgcc gccctgggct gcctggtgaa ggactacttc        480

cccgagcccg tgaccgtgtc ctggaactcc ggcgccctga cctccggcgt gcacaccttc        540

cccgccgtgc tgcagtcctc cggcctgtac tccctgtcct ccgtcgtgac cgtgccctcc        600

tcctccctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag        660

gtggacaaga aggtggagcc caagtcctgc gacaagaccc acacctgccc tccctgcccc        720

gcccccgagc tgctgggcgg cccctccgtg ttcctgttcc ctcctaagcc caaggacacc        780

ctgatgatct cccggacccc cgaggtgact tgcgtggtgg tggacgtgtc ccacgaggac        840

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag        900

ccccgggagg agcagtacaa ctccacctac cgggtggtgt ccgtgctgac cgtgctgcac        960

caggactggc tgaacggcaa ggagtacaag tgcaaggtgt ccaacaaggc cctgcccgcc       1020

cccatcgaga agaccatctc caaggccaag ggccagcccc gggagcccca ggtgtacacc       1080

ctgcccccct cccgggagga gatgaccaag aaccaggtgt ccctgacctg cctggtgaag       1140

ggcttctacc cctccgacat cgccgtggag tgggagtcca acggccagcc cgagaacaac       1200

tacaagacca ccccccccgt gctggactcc gacggctcct tcttcctgta ctccaagctg       1260

accgtggaca agtcccggtg gcagcagggc aacgtgttct cctgctccgt gatgcacgag       1320

gccctgcaca accactacac ccagaagtcc ctgtccctgt cccccggcaa gtga             1374


<210>    80
<211>    1371
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    80
gaggtgcagc tgctggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcggctg         60

tcctgcgccg cctccggctt caccttctcc aactacgcca tgtcctgggt gcggcaggcc        120

cccggcaagg gcctggagtg ggtgtcctcc atctcccaca actccggctc cacctactac        180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac        240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc caagttcatc        300

tccgcccgga agtccctggg ccggtcctac tccaacggca tggacgtgtg gggccagggc        360

accctggtga ccgtgtcctc cgcctccacc aagggcccct ccgtgttccc cctggccccc        420

tcctccaagt ccacctccgg cggcaccgcc gccctgggct gcctggtgaa ggactacttc        480

cccgagcccg tgaccgtgtc ctggaactcc ggcgccctga cctccggcgt gcacaccttc        540

cccgccgtgc tgcagtcctc cggcctgtac tccctgtcct ccgtcgtgac cgtgccctcc        600

tcctccctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag        660

gtggacaaga aggtggagcc caagtcctgc gacaagaccc acacctgccc tccctgcccc        720

gcccccgagc tgctgggcgg cccctccgtg ttcctgttcc ctcctaagcc caaggacacc        780

ctgatgatct cccggacccc cgaggtgact tgcgtggtgg tggacgtgtc ccacgaggac        840

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag        900

ccccgggagg agcagtacaa ctccacctac cgggtggtgt ccgtgctgac cgtgctgcac        960

caggactggc tgaacggcaa ggagtacaag tgcaaggtgt ccaacaaggc cctgcccgcc       1020

cccatcgaga agaccatctc caaggccaag ggccagcccc gggagcccca ggtgtacacc       1080

ctgcccccct cccgggagga gatgaccaag aaccaggtgt ccctgacctg cctggtgaag       1140

ggcttctacc cctccgacat cgccgtggag tgggagtcca acggccagcc cgagaacaac       1200

tacaagacca ccccccccgt gctggactcc gacggctcct tcttcctgta ctccaagctg       1260

accgtggaca agtcccggtg gcagcagggc aacgtgttct cctgctccgt gatgcacgag       1320

gccctgcaca accactacac ccagaagtcc ctgtccctgt cccccggcaa g                1371


<210>    81
<211>    1371
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    81
gaagtacagt tgcttgaaag tggcggtggt cttgtccagc caggcggttc ccttcggctg         60

tcttgcgccg caagtggctt cactttcagc gactatgata tgtcttgggt ccgccaagca        120

ccaggaaagg gacttgaatg ggtgagtgta atcagtcctg acggagggtc aatttattat        180

gcagattcag tcaagggtcg attcactata tcccgagaca actccaaaaa tactctttat        240

cttcagatga actctttgag agctgaagac accgcagttt attactgtgc tcgggatgta        300

gtggagtgca atatgaatcc ctgctcatac gacaacgcaa tggatgtttg ggggcagggg        360

actctggtga cagtcagctc tgcctccacc aagggcccct ccgtgttccc cctggccccc        420

tcctccaagt ccacctccgg cggcaccgcc gccctgggct gcctggtgaa ggactacttc        480

cccgagcccg tgaccgtgtc ctggaactcc ggcgccctga cctccggcgt gcacaccttc        540

cccgccgtgc tgcagtcctc cggcctgtac tccctgtcct ccgtcgtgac cgtgccctcc        600

tcctccctgg gcacccagac ctacatctgc aacgtgaacc acaagccctc caacaccaag        660

gtggacaaga aggtggagcc caagtcctgc gacaagaccc acacctgccc tccctgcccc        720

gcccccgagc tgctgggcgg cccctccgtg ttcctgttcc ctcctaagcc caaggacacc        780

ctgatgatct cccggacccc cgaggtgact tgcgtggtgg tggacgtgtc ccacgaggac        840

cccgaggtga agttcaactg gtacgtggac ggcgtggagg tgcacaacgc caagaccaag        900

ccccgggagg agcagtacaa ctccacctac cgggtggtgt ccgtgctgac cgtgctgcac        960

caggactggc tgaacggcaa ggagtacaag tgcaaggtgt ccaacaaggc cctgcccgcc       1020

cccatcgaga agaccatctc caaggccaag ggccagcccc gggagcccca ggtgtacacc       1080

ctgcccccct cccgggagga gatgaccaag aaccaggtgt ccctgacctg cctggtgaag       1140

ggcttctacc cctccgacat cgccgtggag tgggagtcca acggccagcc cgagaacaac       1200

tacaagacca ccccccccgt gctggactcc gacggctcct tcttcctgta ctccaagctg       1260

accgtggaca agtcccggtg gcagcagggc aacgtgttct cctgctccgt gatgcacgag       1320

gccctgcaca accactacac ccagaagtcc ctgtccctgt cccccggcaa g                1371


<210>    82
<211>    1374
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    82
gaagtgcagc tgcttgaatc aggaggcggc ctcgtacaac cagggggatc tctcagactg         60

tcctgcgctg ccagtggctt cactttcagc aactacgata tgtcatgggt gaggcaggca        120

cctggcaagg gtctggagtg ggtctcaagc ataagtccca gtagtggaag ctcaatttat        180

tacgccgaca gtgtaaaggg ccggttcacc attagtagag acaattctaa gaataccttg        240

taccttcaaa tgaatagtct gagagccgaa gataccgcag tttattattg cgctaaggcc        300

ccagggtggt gtcaggcccc ttcatgctat tatgataatg caatggacgt gtggggtcag        360

ggtactctgg tcacagtcag tagtgcctcc accaagggcc cctccgtgtt ccccctggcc        420

ccctcctcca agtccacctc cggcggcacc gccgccctgg gctgcctggt gaaggactac        480

ttccccgagc ccgtgaccgt gtcctggaac tccggcgccc tgacctccgg cgtgcacacc        540

ttccccgccg tgctgcagtc ctccggcctg tactccctgt cctccgtcgt gaccgtgccc        600

tcctcctccc tgggcaccca gacctacatc tgcaacgtga accacaagcc ctccaacacc        660

aaggtggaca agaaggtgga gcccaagtcc tgcgacaaga cccacacctg ccctccctgc        720

cccgcccccg agctgctggg cggcccctcc gtgttcctgt tccctcctaa gcccaaggac        780

accctgatga tctcccggac ccccgaggtg acttgcgtgg tggtggacgt gtcccacgag        840

gaccccgagg tgaagttcaa ctggtacgtg gacggcgtgg aggtgcacaa cgccaagacc        900

aagccccggg aggagcagta caactccacc taccgggtgg tgtccgtgct gaccgtgctg        960

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgtccaacaa ggccctgccc       1020

gcccccatcg agaagaccat ctccaaggcc aagggccagc cccgggagcc ccaggtgtac       1080

accctgcccc cctcccggga ggagatgacc aagaaccagg tgtccctgac ctgcctggtg       1140

aagggcttct acccctccga catcgccgtg gagtgggagt ccaacggcca gcccgagaac       1200

aactacaaga ccaccccccc cgtgctggac tccgacggct ccttcttcct gtactccaag       1260

ctgaccgtgg acaagtcccg gtggcagcag ggcaacgtgt tctcctgctc cgtgatgcac       1320

gaggccctgc acaaccacta cacccagaag tccctgtccc tgtcccccgg caag             1374


<210>    83
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    83
cagtctgtgc tgacacaacc accttctgcc tctgggactc caggccagcg ggttaccatt         60

agctgttctg gtagttctag taatatcggt aacaacaatg tgaattggta tcaacaactg        120

ccaggaaccg cccctaagtt gctcatatat tatgataaca agcggccttc aggcgttcct        180

gatcgtttct ccggctctaa aagtggcaca tccgccagtc ttgctatcag cggtctcaga        240

tccgaggacg aggccgacta ttattgtggt acatgggacg cttccctgtc aggttacgtc        300

tttggcggcg gcacaaaact gacagttctt ggccagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcc                     648


<210>    84
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    84
cagtctgtgc tgacccagcc tccccctgct tctggcaccc ctggccagag agtgaccatc         60

tcctgctccg gctcctcctc caacatcggc tccaacaccg tgtactggta tcagcagctg        120

cccggcaccg cccccaagct gctgatctac gccaactccc agcggccctc cggcgtgccc        180

gacagattct ccggctccaa gtccggcacc tccgcctccc tggccatctc cggcctgaga        240

tctgaggacg aggccgacta ctactgcggc tcctgggact actccctgtc cggctacgtg        300

ttcggcggag gcaccaagct gaccgtgctg ggccagccta aggccgctcc ctccgtgacc        360

ctgttccccc catcctccga ggaactgcag gccaacaagg ccaccctggt ctgcctgatc        420

tccgacttct accctggcgc cgtgaccgtg gcctggaagg ccgacagctc tcctgtgaag        480

gccggcgtgg aaaccaccac cccctccaag cagtccaaca acaaatacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctacagctg ccaggtcaca        600

cacgagggct ccaccgtgga aaagaccgtg gcccctgccg agtgctcc                     648


<210>    85
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    85
cagagtgttt tgacccagcc tccttccgcc agcggcaccc ctgggcaacg ggttacaatc         60

agctgttccg ggagcagcag taacattggt aataataacg tctcttggta tcagcagttg        120

cctggcacag cacctaagct cctgatttac gctgactccc accggccttc cggcgtccct        180

gatcgtttct ccgggtcaaa aagtggaacc tcagcaagcc ttgcaatcag cggactgcgg        240

tccgaagatg aagctgacta ctactgcgct acctgggatt actcattgtc cggctacgtc        300

tttggggggg gaaccaaatt gacagtcttg ggtcagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcc                     648


<210>    86
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    86
cagtccgtgc tgacccagcc cccctccgcc tccggcaccc ccggccagcg ggtgaccatc         60

tcctgctccg gctcctcctc caacatcggc tccaacgacg tgtcctggta ccagcagctg        120

cccggcaccg cccccaagct gctgatctac tacgacaaca accggccctc cggcgtgccc        180

gaccggttct ccggctccaa gtccggcacc tccgcctccc tggccatctc cggcctgcgg        240

tccgaggacg aggccgacta ctactgcggc gcctgggacg actccctgtc cggctacgtg        300

ttcggcggcg gcaccaagct gaccgtgctg ggccagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcc                     648


<210>    87
<211>    651
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    87
caaagcgtac tcacccagcc cccatccgca tctggcactc ctggtcaacg ggttacaatc         60

tcttgtactg ggtcaagttc caatattgga aataacgcag tgaactggta tcagcagctc        120

cctggcaccg cccctaaact cttgatatac tatgactcta atcggccaag tggagtcccc        180

gataggttct caggttctaa gagtggcaca agtgccagcc tggcaatctc agggctcagg        240

tccgaagatg aggctgatta ttactgcgga gcttgggatg atagcctgag tggctacgtc        300

ttcgggggag gaacaaaatt gaccgtactt ggccagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcctg a                 651


<210>    88
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    88
cagtccgtgc tgacccagcc cccctccgcc tccggcaccc ccggccagcg ggtgaccatc         60

tcctgcaccg gctcctcctc caacatcggc tccaacgacg tgacctggta ccagcagctg        120

cccggcaccg cccccaagct gctgatctac gccgactcca agcggccctc cggcgtgccc        180

gaccggttct ccggctccaa gtccggcacc tccgcctccc tggccatctc cggcctgcgg        240

tccgaggacg aggccgacta ctactgcggc acctgggact actccctgtc cggctacgtg        300

ttcggcggcg gcaccaagct gaccgtgctg ggccagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcc                     648


<210>    89
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    89
caaagtgtat tgactcaacc tccctccgct tccggtacac cagggcagcg agtaaccatc         60

agttgcagtg gcagcagctc caatatcgga agcaattatg taagttggta tcaacagttg        120

ccagggaccg ctccaaaact gttgatctat gacgacagtc accgtccttc aggtgtgccc        180

gaccgatttt caggcagcaa gagcggcaca tccgcctccc tcgctatctc cggcctccga        240

tccgaagatg aggccgacta ctattgtgga gcctgggacg actcccttag tggctatgtg        300

tttgggggag ggacaaagtt gaccgtactt ggccagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcc                     648


<210>    90
<211>    648
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain coding gene


<400>    90
cagtcagttc ttacacaacc cccatccgct tctggcactc ccggccagcg cgtaactata         60

tcttgctctg ggagtagtag caatatcggt aataatgatg tctcatggta ccaacagctg        120

cctggaacag cccccaaact cctcatttat gatgactctc aaaggccaag tggtgtgcca        180

gacagatttt ccggtagcaa gagtggaaca tcagcaagtc ttgctataag tggcttgcgt        240

tccgaggacg aggccgacta ttattgtggc gcatgggatg actcactgag cggctacgtt        300

ttcgggggcg gtactaagtt gaccgttttg ggacagccca aggccgcccc ctccgtgacc        360

ctgttccccc cctcctccga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc        420

tccgacttct accccggcgc cgtgaccgtg gcctggaagg ccgactcctc ccccgtgaag        480

gccggcgtgg agaccaccac cccctccaag cagtccaaca acaagtacgc cgcctcctcc        540

tacctgtccc tgacccccga gcagtggaag tcccaccggt cctactcctg ccaggtgacc        600

cacgagggct ccaccgtgga gaagaccgtg gcccccgccg agtgctcc                     648


<210>    91
<211>    330
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain constant region


<400>    91
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
  1               5                  10                  15 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
 65                  70                  75                  80 

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125 

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175 

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205 

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255 

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270 

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285 

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330


<210>    92
<211>    993
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain constant region coding gene


<400>    92
gcctccacca agggcccctc cgtgttcccc ctggccccct cctccaagtc cacctccggc         60

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc        120

tggaactccg gcgccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagtcctcc        180

ggcctgtact ccctgtcctc cgtcgtgacc gtgccctcct cctccctggg cacccagacc        240

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggagccc        300

aagtcctgcg acaagaccca cacctgccct ccctgccccg cccccgagct gctgggcggc        360

ccctccgtgt tcctgttccc tcctaagccc aaggacaccc tgatgatctc ccggaccccc        420

gaggtgactt gcgtggtggt ggacgtgtcc cacgaggacc ccgaggtgaa gttcaactgg        480

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgggagga gcagtacaac        540

tccacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaag        600

gagtacaagt gcaaggtgtc caacaaggcc ctgcccgccc ccatcgagaa gaccatctcc        660

aaggccaagg gccagccccg ggagccccag gtgtacaccc tgcccccctc ccgggaggag        720

atgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc ctccgacatc        780

gccgtggagt gggagtccaa cggccagccc gagaacaact acaagaccac cccccccgtg        840

ctggactccg acggctcctt cttcctgtac tccaagctga ccgtggacaa gtcccggtgg        900

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc        960

cagaagtccc tgtccctgtc ccccggcaag tga                                     993


<210>    93
<211>    105
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain constant region


<400>    93
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu
  1               5                  10                  15 

Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
             20                  25                  30 

Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val
         35                  40                  45 

Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys
     50                  55                  60 

Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
 65                  70                  75                  80 

His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
                 85                  90                  95 

Lys Thr Val Ala Pro Ala Glu Cys Ser
            100                 105


<210>    94
<211>    318
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain constant region coding gene


<400>    94
cagcccaagg ccgccccctc cgtgaccctg ttccccccct cctccgagga gctgcaggcc         60

aacaaggcca ccctggtgtg cctgatctcc gacttctacc ccggcgccgt gaccgtggcc        120

tggaaggccg actcctcccc cgtgaaggcc ggcgtggaga ccaccacccc ctccaagcag        180

tccaacaaca agtacgccgc ctcctcctac ctgtccctga cccccgagca gtggaagtcc        240

caccggtcct actcctgcca ggtgacccac gagggctcca ccgtggagaa gaccgtggcc        300

cccgccgagt gctcctga                                                      318


<210>    95
<211>    318
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Light chain constant region coding gene


<400>    95
cagcctaagg ccgctccctc cgtgaccctg ttccccccat cctccgagga actgcaggcc         60

aacaaggcca ccctggtctg cctgatctcc gacttctacc ctggcgccgt gaccgtggcc        120

tggaaggccg acagctctcc tgtgaaggcc ggcgtggaaa ccaccacccc ctccaagcag        180

tccaacaaca aatacgccgc ctcctcctac ctgtccctga cccccgagca gtggaagtcc        240

caccggtcct acagctgcca ggtcacacac gagggctcca ccgtggaaaa gaccgtggcc        300

cctgccgagt gctcctga                                                      318


<210>    96
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR2


<400>    96
Ser Ile Ser Pro Asp Ala Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    97
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain CDR3


<400>    97
Gly Gly Asn Ala Ala Trp Asp Thr Gly Phe Asp Tyr
  1               5                  10        


<210>    98
<211>    116
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    98
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser Pro Asp Ala Ser Asn Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asn Leu Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser
        115    


<210>    99
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain variable region


<400>    99
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Tyr His Ser Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Gly Asn Ala Ala Trp Asp Thr Gly Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    100
<211>    446
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    100
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Ser Pro Asp Ala Ser Asn Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Asn Leu Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110 

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala
        115                 120                 125 

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu
    130                 135                 140 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                165                 170                 175 

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu
            180                 185                 190 

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr
        195                 200                 205 

Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
    210                 215                 220 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
                245                 250                 255 

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
            260                 265                 270 

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
        275                 280                 285 

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
    290                 295                 300 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
                325                 330                 335 

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
            340                 345                 350 

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
        355                 360                 365 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
    370                 375                 380 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
385                 390                 395                 400 

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
                405                 410                 415 

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
            420                 425                 430 

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 
 


<210>    101
<211>    451
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain


<400>    101
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Tyr His Ser Gly Ser Ser Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Gly Gly Asn Ala Ala Trp Asp Thr Gly Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
        115                 120                 125 

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
    130                 135                 140 

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val
145                 150                 155                 160 

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala
                165                 170                 175 

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val
            180                 185                 190 

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His
        195                 200                 205 

Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys
    210                 215                 220 

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270 

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350 

Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415 

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445 

Pro Gly Lys
    450    


<210>    102
<211>    1338
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    102
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggctc tctgagactg         60

tcttgcgccg cctccggctt caccttctcc gactactaca tgtcctgggt gcgacaggcc        120

cctggcaagg gcctggaatg ggtgtcctcc atctcccccg acgcctccaa cacctactac        180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac        240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc caagaacctg        300

cgggccttcg actactgggg ccagggcaca ctggtgaccg tgtcctccgc ctccaccaag        360

ggcccctccg tgttccccct ggccccctcc tccaagtcca cctccggcgg caccgccgcc        420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgtcctg gaactccggc        480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agtcctccgg cctgtactcc        540

ctgtcctccg tcgtgaccgt gccctcctcc tccctgggca cccagaccta catctgcaac        600

gtgaaccaca agccctccaa caccaaggtg gacaagaagg tggagcccaa gtcctgcgac        660

aagacccaca cctgccctcc ctgccccgcc cccgagctgc tgggcggccc ctccgtgttc        720

ctgttccctc ctaagcccaa ggacaccctg atgatctccc ggacccccga ggtgacttgc        780

gtggtggtgg acgtgtccca cgaggacccc gaggtgaagt tcaactggta cgtggacggc        840

gtggaggtgc acaacgccaa gaccaagccc cgggaggagc agtacaactc cacctaccgg        900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc        960

aaggtgtcca acaaggccct gcccgccccc atcgagaaga ccatctccaa ggccaagggc       1020

cagccccggg agccccaggt gtacaccctg cccccctccc gggaggagat gaccaagaac       1080

caggtgtccc tgacctgcct ggtgaagggc ttctacccct ccgacatcgc cgtggagtgg       1140

gagtccaacg gccagcccga gaacaactac aagaccaccc cccccgtgct ggactccgac       1200

ggctccttct tcctgtactc caagctgacc gtggacaagt cccggtggca gcagggcaac       1260

gtgttctcct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg       1320

tccctgtccc ccggcaag                                                     1338


<210>    103
<211>    1353
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Synthetic: Heavy chain coding gene


<400>    103
gaggtgcagc tgctggagtc cggcggcggc ctggtgcagc ccggcggctc cctgcggctg         60

tcctgcgccg cctccggctt caccttctcc aactacgaca tgtcctgggt gcggcaggcc        120

cccggcaagg gcctggagtg ggtgtccgcc atctaccact ccggctcctc caagtactac        180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac        240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgcgc ccggggcggc        300

aacgccgcct gggacaccgg cttcgactac tggggccagg gcaccctggt gaccgtgtcc        360

tccgcctcca ccaagggccc ctccgtgttc cccctggccc cctcctccaa gtccacctcc        420

ggcggcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg        480

tcctggaact ccggcgccct gacctccggc gtgcacacct tccccgccgt gctgcagtcc        540

tccggcctgt actccctgtc ctccgtcgtg accgtgccct cctcctccct gggcacccag        600

acctacatct gcaacgtgaa ccacaagccc tccaacacca aggtggacaa gaaggtggag        660

cccaagtcct gcgacaagac ccacacctgc cctccctgcc ccgcccccga gctgctgggc        720

ggcccctccg tgttcctgtt ccctcctaag cccaaggaca ccctgatgat ctcccggacc        780

cccgaggtga cttgcgtggt ggtggacgtg tcccacgagg accccgaggt gaagttcaac        840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agccccggga ggagcagtac        900

aactccacct accgggtggt gtccgtgctg accgtgctgc accaggactg gctgaacggc        960

aaggagtaca agtgcaaggt gtccaacaag gccctgcccg cccccatcga gaagaccatc       1020

tccaaggcca agggccagcc ccgggagccc caggtgtaca ccctgccccc ctcccgggag       1080

gagatgacca agaaccaggt gtccctgacc tgcctggtga agggcttcta cccctccgac       1140

atcgccgtgg agtgggagtc caacggccag cccgagaaca actacaagac cacccccccc       1200

gtgctggact ccgacggctc cttcttcctg tactccaagc tgaccgtgga caagtcccgg       1260

tggcagcagg gcaacgtgtt ctcctgctcc gtgatgcacg aggccctgca caaccactac       1320

acccagaagt ccctgtccct gtcccccggc aag                                    1353
