                         SEQUENCE LISTING

<110>  Y-BIOLOGICS INC.
       PIERRE FABRE MEDICAMENT
 
<120>  ANTI-VSIG4 ANTIBODY OR ANTIGEN BINDING FRAGMENT AND USES THEREOF

<130>  B378459PCTD40837

<150>  KR10-2019-0109365
<151>  2019-09-04

<160>  184   

<170>  PatentIn version 3.5

<210>  1
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210>  2
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu Leu Lys 
    130                 135                 140                 


Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr 
145                 150                 155                 160 


Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr 
                165                 170                 175     


Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala 
            180                 185                 190         


Ile Ile Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala 
        195                 200                 205             


Tyr Ile Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu 
    210                 215                 220                 


Ala Ala Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met 
225                 230                 235                 240 


Arg Val Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser 
                245                 250                 255     


Gln Asn Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu 
            260                 265                 270         


Tyr Gln Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp 
        275                 280                 285             


Thr Val Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val 
    290                 295                 300                 


Cys 
305 


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Phe Ser Leu Thr Thr Ser Gly Val Ala 
1               5                   10  


<210>  4
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Tyr Trp Asp Gly Asp Glu 
1               5           


<210>  5
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Arg Ile Arg Gly Tyr Tyr Asp Trp Gly Ser Tyr Tyr Ser Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Ile Gly Ser Lys Asn 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Asp Ser 
1           


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Val Trp Asp Ser Ser Thr His Val Val 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Phe Ser Phe Asn Thr Pro Gly Glu Gly 
1               5                   10  


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Tyr Trp Asp Asp Glu Lys 
1               5           


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Tyr Ile Phe Thr Asn Tyr Tyr 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Asp Pro Ser Gly Gly Ser Thr 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Arg Asp Tyr Trp Gly Ser Leu Asp Tyr 
1               5                   10  


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Gly Ser Ile Ala Ser Asn Tyr 
1               5               


<210>  15
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Asn Tyr 
1           


<210>  16
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Tyr Asp Ser Arg Asn Arg Asn Tyr Val 
1               5                   10      


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Arg Arg Tyr Ser Ala Tyr Glu Thr Gly Tyr Phe Asp Phe 
1               5                   10                  


<210>  20
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Gly Ile Ser Thr Tyr 
1               5       


<210>  21
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Thr Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Gln Ser Tyr Ser Ala Pro Pro Thr 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Phe Ser Leu Asn Thr Pro Gly Met Gly 
1               5                   10  


<210>  24
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  24

Val Phe Trp Asp Asp Asp Lys 
1               5           


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Trp Asp Ser Asn Ser Asp Gln Tyr Val 
1               5                   10      


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Phe Thr Phe Ser Ser Arg Gly 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Trp Tyr His Gly Ser Asp Asp 
1               5               


<210>  28
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Asn Leu Gly Ala Thr Asp Gly Phe Asp Ile 
1               5                   10      


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Ser Asp Val Ser Ala Tyr Asn Tyr 
1               5                   


<210>  30
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Val Ser 
1           


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Asn Ser Tyr Thr Thr Ser Asn Thr Trp Val 
1               5                   10  


<210>  32
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Ile Ser Ala Tyr Asn Gly Asn Thr 
1               5               


<210>  34
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Arg Asp Tyr Trp Gly Ser Leu Asp His 
1               5                   10  


<210>  35
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Gly Ser Ile Asp Ile Asn Tyr 
1               5               


<210>  36
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Asp Ser 
1           


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Phe Thr Phe Ser Asp His Tyr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Ile Ser Ser Gly Gly Gly Thr Ile 
1               5               


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Arg Arg Glu Tyr Asp Ser Asp Gly His Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  40
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Leu Pro Lys Gln Tyr 
1               5       


<210>  41
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  41

Lys Asp Asn 
1           


<210>  42
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Ser Val Asp Ser Ser Asp Thr Ser Val Val 
1               5                   10      


<210>  43
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Ser Thr Phe Arg Val Ala Trp 
1               5               


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Ile Lys Ser Asn Ser Asp Gly Gly Thr Thr 
1               5                   10  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Arg His Gly Asp Ala Asn Ala Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  47
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Val Ser 
1           


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Ser Tyr Ala Ser Ser Ser Thr Leu Tyr Val 
1               5                   10      


<210>  49
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  50

Ile Ser Trp Asn Ser Gly Asn Ile 
1               5               


<210>  51
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  51

Ala Arg Glu Thr Ala Leu Ala Phe Asp Met 
1               5                   10  


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Gly Ile Ser Tyr Trp 
1               5       


<210>  53
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Ser Ser 
1           


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Leu Gln Ala Thr Ser Phe Pro Tyr Thr 
1               5                   


<210>  55
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  55

Ala Arg Pro Gly Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10      


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  57
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Ala Ser 
1           


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Gln Tyr Ser Ser Leu Trp Thr 
1               5               


<210>  59
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  25  


<210>  60
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  60

Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 
1               5                   10                  15      


Leu 
    


<210>  61
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Tyr Ser Ser Ser Leu Lys Asn Arg Leu Thr Ile Thr Lys Asp Thr 
1               5                   10                  15      


Ser Lys Ser Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  62
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  62

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  63
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn 
            20                  25  


<210>  64
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  64

Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
1               5                   10                  15      


Tyr 
    


<210>  65
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  65

Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
1               5                   10                  15      


Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  66
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  66

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  67
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Val Thr Leu Arg Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser 
            20                  25  


<210>  68
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  68

Val Thr Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala 
1               5                   10                  15      


Leu 
    


<210>  69
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  69

His Tyr Asn Pro Ser Leu Asn Gly Arg Leu Thr Ile Thr Lys Asp Thr 
1               5                   10                  15      


Ser Lys Ser Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  70
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  70

Trp Gly Gln Gly Thr Thr Ile Thr Val Ser Ser 
1               5                   10      


<210>  71
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  71

Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
1               5                   10                  15      


Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  72
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Ile Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Asn Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  73
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  73

Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ile 
    


<210>  74
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  74

Thr Tyr Ala Gln Lys Phe Gln His Arg Val Thr Met Thr Ser Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ile Gly Leu Gly Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  75
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  75

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  76
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  76

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser 
            20                  25  


<210>  77
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  77

Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Val Ile 
1               5                   10                  15      


Tyr 
    


<210>  78
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Arg Pro Ser Glu Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser 
1               5                   10                  15      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp 
            20                  25                  30          


Glu Gly Asp Tyr Tyr Cys 
        35              


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
1               5                   10  


<210>  80
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  81
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Tyr 
    


<210>  82
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  82

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  83
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  84
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  84

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  85
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  85

Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  86
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  86

Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  87
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Val Thr Leu Arg Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Arg 
            20                  25  


<210>  88
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  88

Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly 
1               5                   10                  15      


Leu 
    


<210>  89
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  89

Thr Tyr Arg Pro Ser Leu Arg Asn Arg Leu Thr Ile Thr Lys Glu Thr 
1               5                   10                  15      


Ser Lys Ser Gln Val Val Leu Thr Met Thr Asn Met Asp Pro Val Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  90
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  90

Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
1               5                   10                  15      


Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  91
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  91

Phe Gly Thr Gly Ser Lys Val Thr Val Leu 
1               5                   10  


<210>  92
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  93
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  93

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Leu 
    


<210>  94
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  94

Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  95
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  95

Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
1               5                   10      


<210>  96
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr 
            20                  25  


<210>  97
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  97

Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
1               5                   10                  15      


Tyr 
    


<210>  98
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  98

Asp Arg Pro Ser Gly Val Ser Phe Arg Phe Ser Gly Ser Lys Ser Gly 
1               5                   10                  15      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
            20                  25                  30          


Tyr Tyr Tyr Cys 
        35      


<210>  99
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  99

Gln Met Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  100
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  100

Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  101
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  101

Asn Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  102
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  102

Trp Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  103
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  103

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser 
            20                  25  


<210>  104
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  104

Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Ile Ile 
1               5                   10                  15      


Tyr 
    


<210>  105
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  105

Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Arg 
1               5                   10                  15      


Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp 
            20                  25                  30          


Glu Gly Asp Tyr Tyr Cys 
        35              


<210>  106
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  106

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  107
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Ser 
    


<210>  108
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  108

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  109
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  109

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Leu Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp 
            20                  25  


<210>  110
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met 
1               5                   10                  15      


Tyr 
    


<210>  111
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  111

Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Ser Ser Gly 
1               5                   10                  15      


Thr Thr Val Thr Leu Thr Ile Ser Arg Val Gln Ala Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  112
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  112

Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  15      


Arg 
    


<210>  113
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  113

Asp Tyr Ala Thr Pro Met Lys Asp Arg Phe Ile Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Lys Asn Thr Val Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  114
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  114

Trp Gly Gln Gly Thr Lys Val Thr Val Ser Ser 
1               5                   10      


<210>  115
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  115

Ile Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  116
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  116

Asp Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Ala 
1               5                   10                  15      


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  117
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  117

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  118
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  118

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ser 
1               5                   10                  15      


Gly 
    


<210>  119
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  119

Val Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  120
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  120

Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  121
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  121

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  122
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  122

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Phe 
    


<210>  123
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  123

Arg Leu His Ser Gly Val Pro Ser Arg Phe Asn Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  124
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  124

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  125
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  126
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  126

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  127
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  127

Ile Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  128

Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
1               5                   10  


<210>  129
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  129

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ala Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Gly Asp Glu Arg Tyr Ser Ser Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Gly Tyr Tyr Asp Trp Gly Ser Tyr Tyr Ser Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  130
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  131
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  131

Gln Val Thr Leu Arg Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Phe Asn Thr Pro 
            20                  25                  30          


Gly Glu Gly Val Thr Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Glu Lys His Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Asn Gly Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Gly Tyr Tyr Asp Trp Gly Ser Tyr Tyr Ser Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Ile Thr Val Ser Ser 
        115                 120                 125         


<210>  132
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  132

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asp Thr Ala Thr Leu Thr Ile Ser Gly Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Thr His Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  133
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Ile Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Asn Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Gly Gly Ser Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln His Arg Val Thr Met Thr Ser Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ile Gly Leu Gly Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Trp Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  134
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  134

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Val 
        35                  40                  45              


Ile Tyr Glu Asn Tyr Leu Arg Pro Ser Glu Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Arg Asn Arg Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  135
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  135

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Tyr Ser Ala Tyr Glu Thr Gly Tyr Phe Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  136
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  136

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  137
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Val Thr Leu Arg Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Arg Gly Phe Ser Leu Asn Thr Pro 
            20                  25                  30          


Gly Met Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Gly Leu Val Phe Trp Asp Asp Asp Lys Thr Tyr Arg Pro Ser 
    50                  55                  60                  


Leu Arg Asn Arg Leu Thr Ile Thr Lys Glu Thr Ser Lys Ser Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Arg Gly Tyr Tyr Asp Trp Gly Ser Tyr Tyr Ser Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  138
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  138

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Asn Ser Asp Gln 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Ser Lys Val Thr Val Leu 
            100                 105             


<210>  139
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  139

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr His Gly Ser Asp Asp Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Leu Gly Ala Thr Asp Gly Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Val Val Thr Val Ser Ser 
        115             


<210>  140
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  140

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Ser Ala Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Gly Val Ser Asp Arg Pro Ser Gly Val Ser Phe Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Tyr Tyr Tyr Cys Asn Ser Tyr Thr Thr Ser 
                85                  90                  95      


Asn Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  141
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  141

Gln Met Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Trp Gly Ser Leu Asp His Trp Gly Gln Gly Ala Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  142
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  142

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Asp Ile Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Ile 
        35                  40                  45              


Ile Tyr Glu Asp Ser Gln Arg Thr Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Arg Asn Arg Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


<210>  143
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  143

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Gly Gly Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Glu Tyr Asp Ser Asp Gly His Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
        115                 120         


<210>  144
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  144

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Leu Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr 
        35                  40                  45              


Lys Asp Asn Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Arg Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Val Asp Ser Ser Asp Thr Ser 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  145
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  145

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Arg Val Ala 
            20                  25                  30          


Trp Val Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Asn Ser Asp Gly Gly Thr Thr Asp Tyr Ala Thr 
    50                  55                  60                  


Pro Met Lys Asp Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg His Gly Asp Ala Asn Ala Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Lys Val Thr Val Ser Ser 
        115                 120                 


<210>  146
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  146

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Ile Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Ala Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Ser Ser 
                85                  90                  95      


Ser Thr Leu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  147
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  147

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Asn Ile Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Leu Ala Phe Asp Met Trp Gly Pro Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  148
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  148

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Ala Ser Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Asn Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Ala Thr Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  149
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  149

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Tyr Tyr Tyr Gly Leu Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  150
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Ile Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Ile Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Leu Trp Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  151
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  151
cgtcccatcc tggaagtgcc ag                                                22


<210>  152
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  152
gctctttcct ggcccagcac tgg                                               23


<210>  153
<211>  792
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(L)-Fc)

<400>  153
cgtcccatcc tggaagtgcc agagagtgta acaggacctt ggaaagggga tgtgaatctt       60

ccctgcacct atgaccccct gcaaggctac acccaagtct tggtgaagtg gctggtacaa      120

cgtggctcag accctgtcac catctttcta cgtgactctt ctggagacca tatccagcag      180

gcaaagtacc agggccgcct gcatgtgagc cacaaggttc caggagatgt atccctccaa      240

ttgagcaccc tggagatgga tgaccggagc cactacacgt gtgaagtcac ctggcagact      300

cctgatggca accaagtcgt gagagataag attactgagc tccgtgtcca gaaactctct      360

gtctccaagc ccacagtgac aactggcagc ggttatggct tcacggtgcc ccagggaatg      420

aggattagcc ttcaatgcca ggctcggggt tctcctccca tcagttatat ttggtataag      480

caacagacta ataaccagga acccatcaaa gtagcaaccc taagtacctt actcttcaag      540

cctgcggtga tagccgactc aggctcctat ttctgcactg ccaagggcca ggttggctct      600

gagcagcaca gcgacattgt gaagtttgtg gtcaaagact cctcaaagct actcaagacc      660

aagactgagg cacctacaac catgacatac cccttgaaag caacatctac agtgaagcag      720

tcctgggact ggaccactga catggatggc taccttggag agaccagtgc tgggccagga      780

aagagcctgc ct                                                          792


<210>  154
<211>  264
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(L)-Fc)

<400>  154

Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly 
1               5                   10                  15      


Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln 
            20                  25                  30          


Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile 
        35                  40                  45              


Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln 
    50                  55                  60                  


Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln 
65                  70                  75                  80  


Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val 
                85                  90                  95      


Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr 
            100                 105                 110         


Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr Val Thr Thr 
        115                 120                 125             


Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg Ile Ser Leu 
    130                 135                 140                 


Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile Trp Tyr Lys 
145                 150                 155                 160 


Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr Leu Ser Thr 
                165                 170                 175     


Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser Tyr Phe Cys 
            180                 185                 190         


Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp Ile Val Lys 
        195                 200                 205             


Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys Thr Glu Ala 
    210                 215                 220                 


Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr Val Lys Gln 
225                 230                 235                 240 


Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly Glu Thr Ser 
                245                 250                 255     


Ala Gly Pro Gly Lys Ser Leu Pro 
            260                 


<210>  155
<211>  517
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(L)-Fc)

<400>  155

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Ala Asp 
1               5                   10                  15      


Val His Ser Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Ala Ser Glu Pro Lys 
        275                 280                 285             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    290                 295                 300                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
305                 310                 315                 320 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                325                 330                 335     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            340                 345                 350         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        355                 360                 365             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                405                 410                 415     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            420                 425                 430         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        435                 440                 445             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    450                 455                 460                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
465                 470                 475                 480 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                485                 490                 495     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            500                 505                 510         


Leu Ser Pro Gly Lys 
        515         


<210>  156
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-V-Fc)

<400>  156
cgtcccatcc tggaagtgcc agagagtgta acaggacctt ggaaagggga tgtgaatctt       60

ccctgcacct atgaccccct gcaaggctac acccaagtct tggtgaagtg gctggtacaa      120

cgtggctcag accctgtcac catctttcta cgtgactctt ctggagacca tatccagcag      180

gcaaagtacc agggccgcct gcatgtgagc cacaaggttc caggagatgt atccctccaa      240

ttgagcaccc tggagatgga tgaccggagc cactacacgt gtgaagtcac ctggcagact      300

cctgatggca accaagtc                                                    318


<210>  157
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-V-Fc)

<400>  157

Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly 
1               5                   10                  15      


Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln 
            20                  25                  30          


Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile 
        35                  40                  45              


Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln 
    50                  55                  60                  


Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln 
65                  70                  75                  80  


Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val 
                85                  90                  95      


Thr Trp Gln Thr Pro Asp Gly Asn Gln Val 
            100                 105     


<210>  158
<211>  359
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-V-Fc)

<400>  158

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Ala Asp 
1               5                   10                  15      


Val His Ser Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Ala Ser Glu 
        115                 120                 125             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
225                 230                 235                 240 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Pro Gly Lys 
        355                 


<210>  159
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M1-Fc)

<400>  159
cgtcccatcc tgaccgcccc ccacagcctg gccggacctt ggaaagggga tgtgaatctt       60

ccctgcacct atgaccccct gcaaggctac acccaagtct tggtgaagtg gctggtacaa      120

cgtggctcag accctgtcac catctttcta cgtgactctt ctggagacca tatccagcag      180

gcaaagtacc agggccgcct gcatgtgagc cacaaggttc caggagatgt atccctccaa      240

ttgagcaccc tggagatgga tgaccggagc cactacacgt gtgaagtcac ctggcagact      300

cctgatggca accaagtcgt gagagataag attactgagc tccgtgtt                   348


<210>  160
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M1-Fc)

<400>  160

Arg Pro Ile Leu Thr Ala Pro His Ser Leu Ala Gly Pro Trp Lys Gly 
1               5                   10                  15      


Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln 
            20                  25                  30          


Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile 
        35                  40                  45              


Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln 
    50                  55                  60                  


Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln 
65                  70                  75                  80  


Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val 
                85                  90                  95      


Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr 
            100                 105                 110         


Glu Leu Arg Val 
        115     


<210>  161
<211>  380
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M1-Fc)

<400>  161

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Arg Pro Ile Leu Thr Ala Pro 
            20                  25                  30          


His Ser Leu Ala Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr 
        35                  40                  45              


Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val 
    50                  55                  60                  


Gln Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly 
65                  70                  75                  80  


Asp His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His 
                85                  90                  95      


Lys Val Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp 
            100                 105                 110         


Asp Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly 
        115                 120                 125             


Asn Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala 
    130                 135                 140                 


Ser Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
145                 150                 155                 160 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                165                 170                 175     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            180                 185                 190         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        195                 200                 205             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    210                 215                 220                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
225                 230                 235                 240 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                245                 250                 255     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            260                 265                 270         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        275                 280                 285             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    290                 295                 300                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
305                 310                 315                 320 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                325                 330                 335     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            340                 345                 350         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        355                 360                 365             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380 


<210>  162
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M2-Fc)

<400>  162
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aagggaccgt gcggatgccc       60

tgcagctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      120

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      180

aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg      240

agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct      300

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtt                      345


<210>  163
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M2-Fc)

<400>  163

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Thr 
1               5                   10                  15      


Val Arg Met Pro Cys Ser Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
    50                  55                  60                  


Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr 
                85                  90                  95      


Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  164
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M2-Fc)

<400>  164

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Thr Val Arg Met Pro Cys Ser Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln 
    50                  55                  60                  


Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys 
                85                  90                  95      


Val Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp 
            100                 105                 110         


Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn 
        115                 120                 125             


Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  165
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M3-Fc)

<400>  165
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc       60

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtactgcgg      120

aactaccacc ccgccaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      180

aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg      240

agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct      300

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtc                      345


<210>  166
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M3-Fc)

<400>  166

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Asp 
1               5                   10                  15      


Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Leu Arg Asn Tyr His Pro Ala Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
    50                  55                  60                  


Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr 
                85                  90                  95      


Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  167
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M3-Fc)

<400>  167

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Leu 
    50                  55                  60                  


Arg Asn Tyr His Pro Ala Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys 
                85                  90                  95      


Val Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp 
            100                 105                 110         


Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn 
        115                 120                 125             


Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  168
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M4-Fc)

<400>  168
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc       60

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      120

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatgt gcagcagacc      180

aagttccggg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg      240

agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct      300

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtt                      345


<210>  169
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M4-Fc)

<400>  169

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Asp 
1               5                   10                  15      


Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Val Gln Gln Thr Lys Phe Arg Gly 
    50                  55                  60                  


Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr 
                85                  90                  95      


Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  170
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M4-Fc)

<400>  170

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln 
    50                  55                  60                  


Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Val Gln Gln Thr Lys Phe Arg Gly Arg Leu His Val Ser His Lys 
                85                  90                  95      


Val Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp 
            100                 105                 110         


Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn 
        115                 120                 125             


Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  171
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M5-Fc)

<400>  171
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc       60

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      120

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      180

aagtaccagg gccgcctgga ggtgagccgg cagcccccag gagatgtatc cctccaattg      240

agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct      300

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtt                      345


<210>  172
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M5-Fc)

<400>  172

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Asp 
1               5                   10                  15      


Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
    50                  55                  60                  


Arg Leu Glu Val Ser Arg Gln Pro Pro Gly Asp Val Ser Leu Gln Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr 
                85                  90                  95      


Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  173
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M5-Fc)

<400>  173

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln 
    50                  55                  60                  


Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu Glu Val Ser Arg Gln 
                85                  90                  95      


Pro Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp 
            100                 105                 110         


Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn 
        115                 120                 125             


Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  174
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M6-Fc)

<400>  174
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc       60

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      120

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      180

aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtagc cctgaccctg      240

aaccccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct      300

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtt                      345


<210>  175
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M6-Fc)

<400>  175

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Asp 
1               5                   10                  15      


Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
    50                  55                  60                  


Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ala Leu Thr Leu 
65                  70                  75                  80  


Asn Pro Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr 
                85                  90                  95      


Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  176
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M6-Fc)

<400>  176

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln 
    50                  55                  60                  


Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys 
                85                  90                  95      


Val Pro Gly Asp Val Ala Leu Thr Leu Asn Pro Leu Glu Met Asp Asp 
            100                 105                 110         


Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn 
        115                 120                 125             


Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  177
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M7-Fc)

<400>  177
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc       60

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      120

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      180

aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg      240

agcaccctgg agatggatga ccagggctac tacgtgtgcg ccgtcacctg gcagactcct      300

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtt                      345


<210>  178
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M7-Fc)

<400>  178

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Asp 
1               5                   10                  15      


Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
    50                  55                  60                  


Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Met Asp Asp Gln Gly Tyr Tyr Val Cys Ala Val Thr 
                85                  90                  95      


Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  179
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M7-Fc)

<400>  179

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln 
    50                  55                  60                  


Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys 
                85                  90                  95      


Val Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp 
            100                 105                 110         


Gln Gly Tyr Tyr Val Cys Ala Val Thr Trp Gln Thr Pro Asp Gly Asn 
        115                 120                 125             


Gln Val Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  180
<211>  345
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG(S)4-M8-Fc)

<400>  180
cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc       60

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      120

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      180

aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg      240

agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcaggaccag      300

gccggccacc tgatcgtgag agataagatt actgagctcc gtgtt                      345


<210>  181
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein (hVSIG4(S)-M8-Fc)

<400>  181

Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys Gly Asp 
1               5                   10                  15      


Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr Gln Val 
            20                  25                  30          


Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr Ile Phe 
        35                  40                  45              


Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr Gln Gly 
    50                  55                  60                  


Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu Gln Leu 
65                  70                  75                  80  


Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu Val Thr 
                85                  90                  95      


Trp Gln Asp Gln Ala Gly His Leu Ile Val Arg Asp Lys Ile Thr Glu 
            100                 105                 110         


Leu Arg Val 
        115 


<210>  182
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein + signal sequence (NLS-hVSIG4(S)-M8-Fc)

<400>  182

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Gly Ala Val Gly Ala Pro Ile Leu Glu Val Pro Glu 
            20                  25                  30          


Ser Val Thr Gly Pro Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr 
        35                  40                  45              


Asp Pro Leu Gln Gly Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln 
    50                  55                  60                  


Arg Gly Ser Asp Pro Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp 
65                  70                  75                  80  


His Ile Gln Gln Ala Lys Tyr Gln Gly Arg Leu His Val Ser His Lys 
                85                  90                  95      


Val Pro Gly Asp Val Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp 
            100                 105                 110         


Arg Ser His Tyr Thr Cys Glu Val Thr Trp Gln Asp Gln Ala Gly His 
        115                 120                 125             


Leu Ile Val Arg Asp Lys Ile Thr Glu Leu Arg Val Leu Ala Ala Ser 
    130                 135                 140                 


Ala Ala Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
145                 150                 155                 160 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                165                 170                 175     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            180                 185                 190         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        195                 200                 205             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    210                 215                 220                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
225                 230                 235                 240 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                245                 250                 255     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            260                 265                 270         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        275                 280                 285             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    290                 295                 300                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
305                 310                 315                 320 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                325                 330                 335     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            340                 345                 350         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        355                 360                 365             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 


<210>  183
<211>  513
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein (signal peptide-hVSIG4(L)-Fc)

<400>  183

Gln Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Ala Ala Ala Asp Lys 
        275                 280                 285             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                325                 330                 335     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505                 510         


Lys 
    


<210>  184
<211>  419
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein (signal peptide-hVSIG4(S)-Fc)

<400>  184

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys His Ser Ser Lys Leu Leu Lys 
    130                 135                 140                 


Thr Lys Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr 
145                 150                 155                 160 


Ser Thr Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr 
                165                 170                 175     


Leu Gly Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Ala Ala Ala 
            180                 185                 190         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        195                 200                 205             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    210                 215                 220                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
225                 230                 235                 240 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                245                 250                 255     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            260                 265                 270         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        275                 280                 285             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    290                 295                 300                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
305                 310                 315                 320 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                325                 330                 335     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            340                 345                 350         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        355                 360                 365             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    370                 375                 380                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
385                 390                 395                 400 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                405                 410                 415     


Pro Gly Lys 
            


