                         SEQUENCE LISTING

<110>  Beijing Biocytogen Co., Ltd
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC 
       TNFR2

<130>  1

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  4913
<212>  DNA
<213>  Mus. musculus

<400>  1
agtcaccagc tagagcgcag ctgaggcact agagctccag gcacaagggc gggagccacc       60

gctgccccta tggcgcccgc cgccctctgg gtcgcgctgg tcttcgaact gcagctgtgg      120

gccaccgggc acacagtgcc cgcccaggtt gtcttgacac cctacaaacc ggaacctggg      180

tacgagtgcc agatctcaca ggaatactat gacaggaagg ctcagatgtg ctgtgctaag      240

tgtcctcctg gccaatatgt gaaacatttc tgcaacaaga cctcggacac cgtgtgtgcg      300

gactgtgagg caagcatgta tacccaggtc tggaaccagt ttcgtacatg tttgagctgc      360

agttcttcct gtaccactga ccaggtggag atccgcgcct gcactaaaca gcagaaccga      420

gtgtgtgctt gcgaagctgg caggtactgc gccttgaaaa cccattctgg cagctgtcga      480

cagtgcatga ggctgagcaa gtgcggccct ggcttcggag tggccagttc aagagcccca      540

aatggaaatg tgctatgcaa ggcctgtgcc ccagggacgt tctctgacac cacatcatcc      600

actgatgtgt gcaggcccca ccgcatctgt agcatcctgg ctattcccgg aaatgcaagc      660

acagatgcag tctgtgcgcc cgagtcccca actctaagtg ccatcccaag gacactctac      720

gtatctcagc cagagcccac aagatcccaa cccctggatc aagagccagg gcccagccaa      780

actccaagca tccttacatc gttgggttca acccccatta ttgaacaaag taccaagggt      840

ggcatctctc ttccaattgg tctgattgtt ggagtgacat cactgggtct gctgatgtta      900

ggactggtga actgcatcat cctggtgcag aggaaaaaga agccctcctg cctacaaaga      960

gatgccaagg tgcctcatgt gcctgatgag aaatcccagg atgcagtagg ccttgagcag     1020

cagcacctgt tgaccacagc acccagttcc agcagcagct ccctagagag ctcagccagc     1080

gctggggacc gaagggcgcc ccctgggggc catccccaag caagagtcat ggcggaggcc     1140

caagggtttc aggaggcccg tgccagctcc aggatttcag attcttccca cggaagccac     1200

gggacccacg tcaacgtcac ctgcatcgtg aacgtctgta gcagctctga ccacagttct     1260

cagtgctctt cccaagccag cgccacagtg ggagacccag atgccaagcc ctcagcgtcc     1320

ccaaaggatg agcaggtccc cttctctcag gaggagtgtc cgtctcagtc cccgtgtgag     1380

actacagaga cactgcagag ccatgagaag cccttgcccc ttggtgtgcc ggatatgggc     1440

atgaagccca gccaagctgg ctggtttgat cagattgcag tcaaagtggc ctgacccctg     1500

acaggggtaa caccctgcaa agggaccccc gagaccctga acccatggaa cttcatgact     1560

tttgctggat ccatttccct tagtggcttc cagagcccca gttgcaggtc aagtgagggc     1620

tgagacagct agagtggtca aaaactgcca tggtgtttta tgggggcagt cccaggaagt     1680

tgttgctctt ccatgacccc tctggatctc ctgggctctt gcctgattct tgcttctgag     1740

aggccccagt attttttcct tctaaggagc taacatcctc ttccatgaat agcacagctc     1800

ttcagcctga atgctgacac tgcagggcgg ttccagcaag taggagcaag tggtggcctg     1860

gtagggcaca gaggcccttc aggttagtgc taaactctta ggaagtaccc tctccaagcc     1920

caccgaaatt cttttgatgc aagaatcaga ggccccatca ggcagagttg ctctgttata     1980

ggatggtagg gctgtaactc agtggtccag tgtgctttta gcatgccctg ggtttgatcc     2040

tcagcaacac atgcaaaacg taagtagaca gcagacagca gacagcacag ccagccccct     2100

gtgtggtttg cagcctctgc ctttgacttt tactctggtg ggcacacaga gggctggagc     2160

tcctcctcct gaccttctaa tgagcccttc caaggccacg ccttccttca gggaatctca     2220

gggactgtag agttcccagg cccctgcagc cacctgtctc ttcctacctc agcctggagc     2280

actccctcta actccccaac ggcttggtac tgtacttgct gtgaccccaa gtgcatgtcc     2340

gggttaggca ctgtgagttg gaacagctga tgacatcggt tgaaaggccc acccggaaac     2400

agctgaagcc agctcttttg ccaaaggatt catgccggtt ttctaatcaa cctgctcccc     2460

tagcatgcct ggaaggaaag ggttcaggag actcctcaag aagcaagttc agtctcaggt     2520

gcttggatgc catgctcacc gattccactg gatatgaact tggcagagga gcctagttgt     2580

tgccatggag acttaaagag ctcagcactc tggaatcaag atactggaca cttggggccg     2640

acttgttaag gctctgcagc atcagactgt agaggggaag gaacacgtct gccccctggt     2700

ggcccgtcct gggatgacct cgggcctcct aggcaacaaa agaatgaatt ggaaaggact     2760

gttcctgggt gtggcctcag ctcctgtgct tgtgtggatc cctaaagggt gtgctaagga     2820

gcaattgcac tgtgtgctgg acagaattcc tgcttataaa tgctttttgt tgttgttttg     2880

tacactgagc cctggctgag ccaccccacc ccacctccca tcccaccttt acagccactc     2940

ttgcagagaa cctggctgtc tcccacttgt agcctgtgga tgctgaggaa acacccagcc     3000

aagtagactc caggcttgcc cctatctcct gctctgagtc tggcctcctc attgtgttgt     3060

gggaaggaga cgggttctgt catctcggaa gcccacaccg tggatgtgaa caatggctgt     3120

actagcttag accagcttag ggctctgcaa tcagaggagg gggagcaggg aacaatttga     3180

gtgctgacct ataacacatt cctaaaggat gggcagtcca gaatctccct ccttcagtgt     3240

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtcc atgtttgcat gtatgtgtgt     3300

gccagtgtgt ggaggccaga ggttggcttt gggtgtgttt gatcactctc agttactgag     3360

gcagggctct catctgtacc cagagcttgc acattttcta gtctaacttg cttcagggat     3420

ctctgtctgc ctatggagtg ctcaggttac aggcaggctg ccatacctgc ccgacattta     3480

catgaatact agagatctga attctggtcc tcacacttgt atacctgcat tttatccact     3540

aagacatctc tccaagggct cccccttcct atttaataag ttagttttga actggcaaga     3600

tggctcagtg ggtaaggcag tttgcggaca aacctgatga cctgagttgg atccctgacc     3660

ataaggtaga agagacctga ttcctgcaag ttgtcctctg accaccaccc catacatgct     3720

tctgcatatg tgcacacatc acattcttgc acacacactc acataccata aatgtaataa     3780

atttttttaa ataaattgat tttatctttt aatcattatt tttgcttatc tgtttgttca     3840

tacatggagt tttgctgtat acccagtctg gctgcatcct ccaggcacct tgaacttgga     3900

tattctcctg cctcagtttc gagagtgctg agttataggc atgtgcaacc gtgtcaggac     3960

ccttggcgtt acattatgtt ttcgaatctt atttttccat ctaagactga caaccacctt     4020

gccaaaggat gaccttgact tttgtatcct cttgcctcta cttcccaagt attgggatga     4080

caagtctgtc catcctatga tttgtgtggt gctggggctt gaacccaggg gcctcgtgaa     4140

tgctaggcaa acgcaatcag ctgcccaacc ccgaacttca cttttcacct gtgatttctt     4200

aacatggttc ctgagcagac agcatgatcc tgttgccttg aggagctctg ctcgttgctt     4260

tgacaatgct ctatttacta aagaatactt atagagttca agactccaaa gcagcagttc     4320

ccaacctgtg ggtatgacct cttgggtatc ccatatcaga tatttacatt aaacttataa     4380

cagaagcaaa attacagtta tggggtagca acaaaataat ttttttttga ggcagggttt     4440

atctgtgtag ctcactttgt acagactagg ctggccttga acttaaagat ctgcctgcct     4500

ctgccttctg aatgctggga ttaaatgtgt gtgccaacat gcccagtgca gtgaaataat     4560

tttattgttg ggtcaccaaa acatgagaaa gagtattaaa aggtcatagc gttaggaagg     4620

ttgagaacca ctgccccaaa agatagtaga aataggtaat agcattttaa aaaaagatta     4680

atttcttttt ccgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     4740

gtgtgtgaag ggtgctgaat tccctaaatc tgggattaca gacaattgtg ccaaatgggt     4800

attgggaacc aaagttgggt tttctgaaag agcagcaagt gcccttaact gctgagccct     4860

ctctctagct ataataaact tttttttaaa aaaattaaaa aaatttagca ctc            4913


<210>  2
<211>  474
<212>  PRT
<213>  Mus. musculus

<400>  2

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Phe Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Gln Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Lys Pro Glu Pro Gly Tyr Glu Cys Gln Ile Ser Gln Glu Tyr Tyr Asp 
        35                  40                  45              


Arg Lys Ala Gln Met Cys Cys Ala Lys Cys Pro Pro Gly Gln Tyr Val 
    50                  55                  60                  


Lys His Phe Cys Asn Lys Thr Ser Asp Thr Val Cys Ala Asp Cys Glu 
65                  70                  75                  80  


Ala Ser Met Tyr Thr Gln Val Trp Asn Gln Phe Arg Thr Cys Leu Ser 
                85                  90                  95      


Cys Ser Ser Ser Cys Thr Thr Asp Gln Val Glu Ile Arg Ala Cys Thr 
            100                 105                 110         


Lys Gln Gln Asn Arg Val Cys Ala Cys Glu Ala Gly Arg Tyr Cys Ala 
        115                 120                 125             


Leu Lys Thr His Ser Gly Ser Cys Arg Gln Cys Met Arg Leu Ser Lys 
    130                 135                 140                 


Cys Gly Pro Gly Phe Gly Val Ala Ser Ser Arg Ala Pro Asn Gly Asn 
145                 150                 155                 160 


Val Leu Cys Lys Ala Cys Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser 
                165                 170                 175     


Ser Thr Asp Val Cys Arg Pro His Arg Ile Cys Ser Ile Leu Ala Ile 
            180                 185                 190         


Pro Gly Asn Ala Ser Thr Asp Ala Val Cys Ala Pro Glu Ser Pro Thr 
        195                 200                 205             


Leu Ser Ala Ile Pro Arg Thr Leu Tyr Val Ser Gln Pro Glu Pro Thr 
    210                 215                 220                 


Arg Ser Gln Pro Leu Asp Gln Glu Pro Gly Pro Ser Gln Thr Pro Ser 
225                 230                 235                 240 


Ile Leu Thr Ser Leu Gly Ser Thr Pro Ile Ile Glu Gln Ser Thr Lys 
                245                 250                 255     


Gly Gly Ile Ser Leu Pro Ile Gly Leu Ile Val Gly Val Thr Ser Leu 
            260                 265                 270         


Gly Leu Leu Met Leu Gly Leu Val Asn Cys Ile Ile Leu Val Gln Arg 
        275                 280                 285             


Lys Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val 
    290                 295                 300                 


Pro Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu 
305                 310                 315                 320 


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
                325                 330                 335     


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
            340                 345                 350         


Val Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg 
        355                 360                 365             


Ile Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
    370                 375                 380                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
385                 390                 395                 400 


Ser Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala 
                405                 410                 415     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
            420                 425                 430         


Gln Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly 
    450                 455                 460                 


Trp Phe Asp Gln Ile Ala Val Lys Val Ala 
465                 470                 


<210>  3
<211>  3682
<212>  DNA
<213>  Homo sapiens

<400>  3
gcgagcgcag cggagcctgg agagaaggcg ctgggctgcg agggcgcgag ggcgcgaggg       60

cagggggcaa ccggaccccg cccgcaccca tggcgcccgt cgccgtctgg gccgcgctgg      120

ccgtcggact ggagctctgg gctgcggcgc acgccttgcc cgcccaggtg gcatttacac      180

cctacgcccc ggagcccggg agcacatgcc ggctcagaga atactatgac cagacagctc      240

agatgtgctg cagcaaatgc tcgccgggcc aacatgcaaa agtcttctgt accaagacct      300

cggacaccgt gtgtgactcc tgtgaggaca gcacatacac ccagctctgg aactgggttc      360

ccgagtgctt gagctgtggc tcccgctgta gctctgacca ggtggaaact caagcctgca      420

ctcgggaaca gaaccgcatc tgcacctgca ggcccggctg gtactgcgcg ctgagcaagc      480

aggaggggtg ccggctgtgc gcgccgctgc gcaagtgccg cccgggcttc ggcgtggcca      540

gaccaggaac tgaaacatca gacgtggtgt gcaagccctg tgccccgggg acgttctcca      600

acacgacttc atccacggat atttgcaggc cccaccagat ctgtaacgtg gtggccatcc      660

ctgggaatgc aagcatggat gcagtctgca cgtccacgtc ccccacccgg agtatggccc      720

caggggcagt acacttaccc cagccagtgt ccacacgatc ccaacacacg cagccaactc      780

cagaacccag cactgctcca agcacctcct tcctgctccc aatgggcccc agccccccag      840

ctgaagggag cactggcgac ttcgctcttc cagttggact gattgtgggt gtgacagcct      900

tgggtctact aataatagga gtggtgaact gtgtcatcat gacccaggtg aaaaagaagc      960

ccttgtgcct gcagagagaa gccaaggtgc ctcacttgcc tgccgataag gcccggggta     1020

cacagggccc cgagcagcag cacctgctga tcacagcgcc gagctccagc agcagctccc     1080

tggagagctc ggccagtgcg ttggacagaa gggcgcccac tcggaaccag ccacaggcac     1140

caggcgtgga ggccagtggg gccggggagg cccgggccag caccgggagc tcagattctt     1200

cccctggtgg ccatgggacc caggtcaatg tcacctgcat cgtgaacgtc tgtagcagct     1260

ctgaccacag ctcacagtgc tcctcccaag ccagctccac aatgggagac acagattcca     1320

gcccctcgga gtccccgaag gacgagcagg tccccttctc caaggaggaa tgtgcctttc     1380

ggtcacagct ggagacgcca gagaccctgc tggggagcac cgaagagaag cccctgcccc     1440

ttggagtgcc tgatgctggg atgaagccca gttaaccagg ccggtgtggg ctgtgtcgta     1500

gccaaggtgg gctgagccct ggcaggatga ccctgcgaag gggccctggt ccttccaggc     1560

ccccaccact aggactctga ggctctttct gggccaagtt cctctagtgc cctccacagc     1620

cgcagcctcc ctctgacctg caggccaaga gcagaggcag cgagttgtgg aaagcctctg     1680

ctgccatggc gtgtccctct cggaaggctg gctgggcatg gacgttcggg gcatgctggg     1740

gcaagtccct gactctctgt gacctgcccc gcccagctgc acctgccagc ctggcttctg     1800

gagcccttgg gttttttgtt tgtttgtttg tttgtttgtt tgtttctccc cctgggctct     1860

gccccagctc tggcttccag aaaaccccag catccttttc tgcagagggg ctttctggag     1920

aggagggatg ctgcctgagt cacccatgaa gacaggacag tgcttcagcc tgaggctgag     1980

actgcgggat ggtcctgggg ctctgtgcag ggaggaggtg gcagccctgt agggaacggg     2040

gtccttcaag ttagctcagg aggcttggaa agcatcacct caggccaggt gcagtggctc     2100

acgcctatga tcccagcact ttgggaggct gaggcgggtg gatcacctga ggttaggagt     2160

tcgagaccag cctggccaac atggtaaaac cccatctcta ctaaaaatac agaaattagc     2220

cgggcgtggt ggcgggcacc tatagtccca gctactcaga agcctgaggc tgggaaatcg     2280

tttgaacccg ggaagcggag gttgcaggga gccgagatca cgccactgca ctccagcctg     2340

ggcgacagag cgagagtctg tctcaaaaga aaaaaaaaag caccgcctcc aaatgccaac     2400

ttgtcctttt gtaccatggt gtgaaagtca gatgcccaga gggcccaggc aggccaccat     2460

attcagtgct gtggcctggg caagataacg cacttctaac tagaaatctg ccaatttttt     2520

aaaaaagtaa gtaccactca ggccaacaag ccaacgacaa agccaaactc tgccagccac     2580

atccaacccc ccacctgcca tttgcaccct ccgccttcac tccggtgtgc ctgcagcccc     2640

gcgcctcctt ccttgctgtc ctaggccaca ccatctcctt tcagggaatt tcaggaacta     2700

gagatgactg agtcctcgta gccatctctc tactcctacc tcagcctaga ccctcctcct     2760

cccccagagg ggtgggttcc tcttccccac tccccacctt caattcctgg gccccaaacg     2820

ggctgccctg ccactttggt acatggccag tgtgatccca agtgccagtc ttgtgtctgc     2880

gtctgtgttg cgtgtcgtgg gtgtgtgtag ccaaggtcgg taagttgaat ggcctgcctt     2940

gaagccactg aagctgggat tcctccccat tagagtcagc cttccccctc ccagggccag     3000

ggccctgcag aggggaaacc agtgtagcct tgcccggatt ctgggaggaa gcaggttgag     3060

gggctcctgg aaaggctcag tctcaggagc atggggataa aggagaaggc atgaaattgt     3120

ctagcagagc aggggcaggg tgataaattg ttgataaatt ccactggact tgagcttggc     3180

agctgaacta ttggagggtg ggagagccca gccattacca tggagacaag aagggttttc     3240

caccctggaa tcaagatgtc agactggctg gctgcagtga cgtgcacctg tactcaggag     3300

gctgagggga ggatcactgg agcccaggag tttgaggctg cagcgagcta tgatcgcgcc     3360

actacactcc agcctgagca acagagtgag accctgtctc ttaaagaaaa aaaaagtcag     3420

actgctggga ctggccaggt ttctgcccac attggaccca catgaggaca tgatggagcg     3480

cacctgcccc ctggtggaca gtcctgggag aacctcaggc ttccttggca tcacagggca     3540

gagccgggaa gcgatgaatt tggagactct gtggggcctt ggttcccttg tgtgtgtgtg     3600

ttgatcccaa gacaatgaaa gtttgcactg tatgctggac ggcattcctg cttatcaata     3660

aacctgtttg ttttaaaaaa aa                                              3682


<210>  4
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  5
<211>  4468
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5' arm

<400>  5
agctcagtta ccaccaccca agggatatac ctaccccagg gctggcaggg caagtgttcc       60

catgagatgc acacaccgac agcccgtgtg tggagccgga ggctgctgtt tgaggaagta      120

gaggagggtg aagagaaggt tcttagttaa tgagacaaat agtttcccca ggaaggctag      180

tctgggagtt ttattgggga cactcaggcc ttctgtgtca gttagcattc tttggagtga      240

tggatacaaa tgagctatga cactgatttc tggggtccaa ggctccccta attctgctgt      300

gtaccttcct cactcctttc tcccaactta ccttactttc tccatgggat aggatactca      360

gaccacattg agtagagcag aggagtctct aatccccagg aagagttctt tcttatttta      420

tctttcctct ttatgagcag tgtggctccc cagcccagag actctccccc cttagatgtg      480

aaagggtcag ccagccattg atgtaccctt tgatgtgttt gttacattag cagttctcat      540

ctgaacacaa cacactgggt ccgagcggtt ccacgtgtga gatgtttatt gggagggggg      600

cgcaggggag aaggtgacag cagaaagaga aggggaaaaa gagagagagg gcctccttag      660

aagtgggaac aaaacaccct tggaaggagt tacagagaca aagtttggag ctgagattaa      720

agggtggacc atgtagagac tgccttatcc agggatccac cccataatca gcatccaaac      780

gctgacacca ttgcatacac tagcaagatt ttatcgaaag gacccagatg tagctgtctc      840

ttgtgagact atgccggggc ctagcaaaca cagaagtgga tgcccacagt cagctaatgg      900

atggatcaca gggctcccaa tggaggagct agagaaagta cccaaggagc taaagggatc      960

tgcaacccta taggtggatc aacattatga actaaccagt accccggagc tcttgactct     1020

agctgcacat gtatcaaaag atggcctagt cggccatcac tggaaagaga ggcccattgg     1080

acacacaaac tttatatgcc ccagaacagg ggaatgccag ggccaaaaag ggggagtggg     1140

caggtagggg agtgggggtg ggtgggtatg ggggactttt ggtatagcat tggaaatgta     1200

aatgaactaa atacctaata aaaaatggaa aaaaaaaaag gaaaaaaaaa gagatattaa     1260

ggaaaagtaa aaaaaaaaaa agagagagag agagggaggg ctgttcccct tatttatatg     1320

aaaaaaatga cgtaacacag gtaaaggtgg gaggtgagcc aagtggattc tgggaatatg     1380

ctgcaggtcg cgctgtcacc tatgtgatgt cataggtttg ggaggtcctg atgcaaagac     1440

ccttgacctt gagaacagtc agtgaggtcc cagacagtgt ggaacaccct tatttgtgtg     1500

ctcagactca actggttgtt ttgtcaagaa atggaacggg gaagtgccag gatattgtgt     1560

gtaggcatgt gcgcatgcgc ttggatgtgt gtgcagctgt ccagagggag ctgcagtggc     1620

tttttcagac tgggtactca gcatggttct gcgacttccc tcacccagct gtctgcatga     1680

ccttcctgaa aaggattgcc ttgatggagg aactcagaga taggccaggg cagcagatgc     1740

atctatgttc aagcttcttg gccctggtgc ccagggggag gctctcgcct caaggaaatg     1800

acattagaat tattacctta ctcagggtag caactattga ttactctttt ctgtctggct     1860

ctggataggg tagctcgcac tgcagcctcc aatgggccct catctggggt tactgggtga     1920

gcatgaagac aaggcagggg gctggctgta ttgggttgct tatccagggc acggtgtgca     1980

cagtcgcctg aagagggaag cactctgtgt ggacttttgg ccaaaggcgc aagaggcagc     2040

tagggtactg tggcaggtcc agaagagcca aagactgtcc acagcataga accccagtcc     2100

cttgagtcat ggcttctggt ggctttcagc tgttatcact gagtggctga gcaaagagaa     2160

acatgatagg ctcagaggtc actcagtgca cagcactagg caaggtaggg tgatgctctc     2220

cagacacagc tggggatggg aaggggaaag acagaaagca gagccactgc ccacagatca     2280

tgggagtttg tgcagtctat acagaccaaa tgagcctaat agtaaggtcg gcatcttctc     2340

tgattggctt gtttgcagtg gcttttcaga gactgatcca tgcctttgct gtgctaattg     2400

ttggatattt tatgtatctc tcttgctccc atagaattga gtcaggaacc gatgtccaga     2460

gagataggga cacttgattg actatgacca tacagcttct ggatggaaga ataagaaaag     2520

aagaccacat ctctctaact ctccaccttt atctgaggag tcaggggatt catttgggtt     2580

actggtttaa taaacattta ttaagctcct gctgaccata tgacggcagc tgctggtaca     2640

atcaagagtg cggagcagcc ttcctcttta acctagaacc accccttggt catttccagg     2700

tgacatcagc agaggctgca agggtgttga gtgtgtgttc acaccctctt tgctcttgta     2760

gatccactcc catgtttgct catgagttca catttgtgca gaaatggcta attcatgctt     2820

gtccctaaag tttccaattg ctgttccacc ttctggaaga aaggctgggg cttaggcagg     2880

tctctgaggt actgggatag acccagtggt gacagttgct gctgctgtac acttctgaga     2940

actgaggacc tcttggagat ctgagggagg gctctgtgtt tctcacagtt ggttctgtgc     3000

catgttgggt gtttttttgt tttttgtttt ttctcctccc catttgtctc cctttcataa     3060

ttatttattt aattaaaaaa tgtgagtact cctgagtata tgtatgtgaa ccacacacat     3120

tcaggagtat gcagaactta gaagggagcg tcaggttacc tggaactgga gtgacagaca     3180

gttgtgagct gccatgttgg tgctgggaac tgatcccaag ttgtctccaa gaatagtaag     3240

tgcccctaac cactgcgcta tctctggagc tcctcctccc catcctcccc atcgctccct     3300

gctttcctgg tctctccctg gaagtgctta gcccagtcat tgaaatcatg gcctagagag     3360

acagacagga cccaggctca aatctctgtc actgccttag gtgggtaacc tgtgctcgtt     3420

atgcctgttt cctttctata caatggtcgg agtccaacat ggctggttgt tagagaactg     3480

aatgcaataa tacatccatc tcaggtccag gctctggaag cacagcctga ggcatggctt     3540

cttgtaacag gagaaggctc tcaggcaaga gggtggggtg gcaggatgtg gcagcagggt     3600

cacatgtttt ccagccaaaa cctatgagtg ttggtcttgg gttgaggcca aggtactgcc     3660

tttgagttgg agacttgtcg gccagtgctg aggctattct cctggcagtt ggagtctgag     3720

catggctagg agcccccact ggtccaaacc ttctaagccc ataggtgtaa ggcagcactg     3780

atgtgaggag gtgcacaggt ttgttttcat tctgtattaa cttcctgagg cagctctgcc     3840

atggcctgtg tcagaagctt gggtctagag gtggcgcagc cattatctgt gtcataggtg     3900

gcagcatatg gacacatgta tgtacacctg tgtgcatatg catggatgtg agtgcaagga     3960

cacacggtgc caattcagaa caatgacatg aaggtcagaa ggggccatgt ctatattcag     4020

agagaaccca gaggaggaag agcctacatt aggcccagga gagtagaggg tacttctggg     4080

agaaggaaga cctcagccac aaggacagag ggacagatgg acagacatcc taaaaagaga     4140

agctttgtgt ggaggtcctt gtcacagtga gtcaagccac tgtcttaaaa aaactacatc     4200

ttctcagagc cttgctgggt ctcacccagc aggcaggagg gaagccctaa agtaacccac     4260

ttcctggccc agcaaactgc agacacaagc gtgccacgct gaagaggaag gccaagaagg     4320

gaaaaagcct gggctctact ctctcaagcc ttcctcgtcc tccaacgcaa aaacccatcc     4380

atgaggcctg gtgacaggta tgctggagcc cagagtcata ctgatggctg cctcccttgt     4440

tcccttccag gttgtcttga caccctac                                        4468


<210>  6
<211>  3487
<212>  DNA
<213>  Artificial sequence

<220>
<223>  3' arm

<400>  6
agatgcaagt gtagaagagt tgagtctcca aagatgtgat attgccatag ggaatccctg       60

ggtggcatga atgtgaacat aggttctggt tgctagttat gatgaacccg tttgtctcac      120

agactatgga ctgctggtgt ctctggcttc cctctggggt taggatggta ccaagcccaa      180

ggccctacac tgtagccttc tgactgcatg tggtttgcag atgtgatctt tggtttgacc      240

ctgaatttga gggcctaagg ctggacttga tctcagcatc agcaccagcc accctggaac      300

ctttgtttct gagtaccctg ccgttttcct aggtctgatt gttggagtga catcactggg      360

tctgctgatg ttaggactgg tgaactgcat catcctggtg cagaggaaaa gtaaggttct      420

gctctcgtcc tgtttcccgc cccacgtccc taccctaaca ctttctcgga gccttgggtg      480

gcaggcctcg ttcagagctc tgcactatca tagactcggg tggatctgga gactgtagcc      540

tcttgctctc caggaactta gagcctggtg tagaaggtac atactctaac ctggctacca      600

gaaggtagtg tcaaggctat tccaggggat tgaagttcag gatttttata caggaagcct      660

ggagtctctc ggattctgtg agctggcctg ggtctcagtg ggtggagtgt gttgaggcag      720

ggctacaaca caggctgtac tggaggatgg ctggggcaaa ggggtagtgg ctgaaagtag      780

catgggctca tccgtgaaca tgacaggcag ctactccctg ggctgggtcc actctcctgg      840

ctctacccta gccatgctgt gcccattaag acagctgttc tgaagaagtc ctgcctctga      900

cttgttcccc tctcttcatt gtagagaagc cctcctgcct acaaagagat gccaaggtgg      960

tgagtatccc tctgcggtcc tcctccccct tctctcctcc agctctccct cttcctcctc     1020

ctctttctcc tcctcttcca gttcctttac tagggcatca taagcaacat catataagca     1080

ggatctaatg tatatggtgg tgcatacctg ccatcccaat agttaggggc aggtagaggc     1140

tggagggtca gagtgtaaat actccctcag agccagctga tgtttagttc cattacagtt     1200

gggaagaaac cggcaaactc tcccctagct gggcatagcc aggctctttc cctaggctat     1260

gtccaactcc tcactggtcc tatgcataag gcaccttggc tcctcattat atagatgagg     1320

aaatgtaggc ttaacagata cagtcaccct tgaaaggttg tgttgtgtcc tggtggtcaa     1380

accctctgcg catgtgcatc cggcagctac acccaaagct gtctcaggct ggcctctcct     1440

agcagggact gctcgccaag actggtcacc aggatttgga gaacctagat gccccccttt     1500

gtccagccct gtgccctgtc agctacctgc cccagggccc tactctggag cccagtggac     1560

ggtgtcctca tgtgctagag tgaggaggct gtcaggcagg agcagcagtg actcagcttc     1620

tactctgagg actggggaag atgaggttat ctggaaaaac agcacgtgaa ttcatctaca     1680

cctcccccag tcatgcgcat ggttcatgtt tagtcgccgg cagttactgg tggtggtgga     1740

ggaaggacgt gccagcactg tctgagggct tattcttcca gcttgactgt gacacaggct     1800

atgacacagg ctgtggcaca ggctgtgaca gaggttattg cccccaacgt tagacagagt     1860

ctgggattat atggctcaga cactcttaag taattgtcct gtgtcctagc tgtgtcctag     1920

acacagctaa tgggtatggc ctggaacaca aacttagcat acaattacta cccagcatac     1980

aattactgtg ccactcttag gcatgcccac atgagcctgc acatataaat acccttagct     2040

cagaggccga cagaagccag ccatgcttct gccagtccca gttccatata acaggaccag     2100

acccagaacc ataggaggta tcaggcaagc taagattttt tggtgttcat tcagtggggt     2160

cctagccaga gtcacatgac tctgatagtg tctgtacttg aacactgtag cttgtggctt     2220

tgaagaagct agctgtgacc tttggggagg aggggaagat cgggttctgt ctggctctag     2280

ccacaagcag aaagggggag gcccagacag aaaagctcct tctctggggc tggtgtggtg     2340

tgacatttat gagtgcctct gtagagttac agggtaaggc cagggccaag gtcagaccgt     2400

gagttcagga tgtttttcct ctcttccatt ttggggtacc tagctgggag gaccccaggg     2460

gagtcaggag gatgcagtgg gcatgctccc acatcctaga ctgggtttgc ttactgtggc     2520

catcagccag ctctgtaact ctgagctctg gattcatctt ctgtgggctt ttgtggcctc     2580

atgaagacag cttgtataag atccttccag tccagagtca gaagctgtgg actgtgcagg     2640

aaacaaggcc tcaaggccat gtatcatgac atacctgggc atctaagaag acatagcaac     2700

agtgggcagg acctggagat ggaagtttta gtgactctct agagagcacc agccacagga     2760

aggatagccc aactattgtt tcagcttaga ctacacctgg cattgtgcct ccctggaaaa     2820

gtgtggccac ttttccagct gctgtcaaca gacaatggcc ttggaataga tgtccttagc     2880

ataagttgcc atgaacaggg aatttgtctt aagcctcaag agctgaaccc cagacaccca     2940

gaagaggcat ggtgagtttt tagctcgact gcactgtatc caaaccatgg cctcaggcag     3000

aaagttccgt ttccatattt acagagctag gatggcacta ggctatattg agtgtctaga     3060

agagctgaga ccaatgtgac tcaggcacag gatttggcac taggtgctca tgtcacatac     3120

agagtaagaa gccacaggga agccacacga catcatctgg gtgaactgtg ggaacgggca     3180

gctgagaaga ccagtgagga accctgtgag tggccctgtg agtggccctg aggaaaggac     3240

cccatgggcc agggtgattc attgagcaga aggaatgaag agtaaaggtg ttaagcttca     3300

agcaccaagg ctggcctctg ggacagctac tctgatctgc cacccaccat caggaagtct     3360

gtgctttgca aaacattgat gacagctcag gtgcatcaaa cttgtttatt tacgaacact     3420

aaaacttgac ctttagattt gaggcatttt gtattttaga cacggactta tgtagcctgt     3480

attgacc                                                               3487


<210>  7
<211>  4275
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NC_000001.1112188814 to 12193088

<400>  7
gccccggagc ccgggagcac atgccggctc agagaatact atgaccagac agctcagatg       60

tgctgcagca aatgctcgcc gggtgagggc agccacgggg gcactcgggg cccatgccct      120

ggaggagcgt gtgtgtacag gggctggggc gcaagagcat agcccttgat tcttactgaa      180

ctcctagttc tatgcactgg cccatgctcc ctgctgcttc tgggcctgtg aacatgctgt      240

tccctcttcc tggcacactt cccaactccc tttccctgat taactccaac ttgcccttta      300

gacctcagct gaagatgtcc cctcttccag gaaggctgcc tgccccatac tgcccagccg      360

gtggaggagg gggaggagga gcctaaatta gctcctgggg gagtcaggga gggctgcctg      420

gaggaggcag cactcagctt gaaagacaag tgctgcctcc tttgagctct cactggcctc      480

tgatgttccc atggaagctc tttccttgct gtgggattat agcccggtcc tgcttcctgt      540

tgcctccact gtgtgctcct ctagggcaga gattgtggct tgttttctgc tgaatcccca      600

gcacgtggcg caatgccatg taggtgctca gtgcatattt gactgactct gtgaatgctt      660

acccatttca cagatggtag acctgaggcc cagccacagt tggtggagct aggtagcctg      720

actcctggtg ccctccatct attcatttgt gtctgtattc attcatgtca tgattataag      780

gtatctgctg tgtgttctaa gtgctgggaa tacacagaga gcagggcaga caaaaccctt      840

gccctcgtgg agtctgcatt ttaacggtgg atgcagacag atacattagg agatgtgtgg      900

tcctgtctat ctgtaagtgc tgtagaaaga caaggtcagg taaggcgggg gagacagaac      960

gggacatact gttttacaca gggtggtctg ggaaggtctc tctgaggagg tgacatttgg     1020

gcagagccct gcaggaggtg agggagcagg tcatgcatgt atacagggaa cagtgtgcca     1080

ggaggaagca acagcatgtg cgaaggcctt gaagtcggag cctgtttggt gagttggagg     1140

aacagcaggg ccagcatgtg tggcccagga tgagcgaagg cgagtacggt aggggaggag     1200

gaggaaggag tgagcaggga ccatggtaag gagtttagat tttattctgt ctgggagcca     1260

atggagggct ttgagccgtt accttgagat gtaggtgggc atatgagtac ctgtcaccgt     1320

ccctagccat tttaagacat cctagggaaa gtgactctct tctttctttt attaactgga     1380

agggtctctt taagaagtta ctagagaggc tgaggtgggc ggaccaccgg aggccaggag     1440

tttgagacca gcctggccaa catggtggaa cccgtctcta ctaagaatac aaaaaaatag     1500

ctgggcataa tggcaggcac ctgtaatccc agctacttgg gaggctgagg caggagaatt     1560

gcttgagcct gagaggcaga ggttgcagtg agccgagatt gtgccactgc actctagcct     1620

gggccacaga gtgagattct gtctcaaaaa aaaaaaaaaa aaaaaaagca gctactgagt     1680

caactttttt ttaaggtttc cgttggtgtt ctctgtccct ggaatgcctg ctttccaggc     1740

ccatgccctt gtccttgata ggataccagg gactacattc ttactacctg ttccccctat     1800

cattcatgcc cctagctgga gaatattagc catctatcaa gaaggaagaa actggcaagc     1860

tagttcttac taaagtgtga ttgactgata atagggctcc agtggtggag gttcaagcat     1920

ctggaaagag cagagaggaa tctatttttg agcagaaggg gttcagaaat gacgtgatag     1980

ctggtacaat actagatggg agatgattct gaggaattgg aactccacag aatagccttc     2040

ccagctgggc tttagaactc tggactttgt ggggacagtg gatgagccca gggtcctggc     2100

agaaggctcg cccagctgag acctctggcc cttgtttcct caggccaaca tgcaaaagtc     2160

ttctgtacca agacctcgga caccgtgtgt gactcctgtg aggacagcac atacacccag     2220

ctctggaact gggttcccga gtgcttgagc tgtggctccc gctgtagctc tggtgagtag     2280

gttcagagaa aaagggggcc cttacacccc tgcctccaac ttcccccggc aactccagcc     2340

tctttggctt ccagctgtct ggagttaccc caggctggtt gttggaagtg gcacaggtgc     2400

agctgtttac ccctaccact ggcattttcc tcctctgtct caccaaagcc tcttcacagc     2460

cccacggggc aggcggtggg agaactgtgc ccacgtgagg gttgaggagg tggtgcgtgg     2520

gagagtggtg cgcatgctcg tgctgcgagg agcaggactg cggggaggag cgaaactgct     2580

gggaagagcg ggactgcggg gaagagcggg acttcgggga ggagcggcac tgcggggagg     2640

agcaggactg cagggaggag cgggactgtg gggaggagcg ggacttcggg gaggagcggg     2700

actgcggggg acgagcgcga ctgcggggga cgagcaggac tgcggagagt agcgggactg     2760

cggagagtag cgggactgcg gagagtagca ggactgccgg tcctgcccct ggactctggc     2820

cggtgttgtg tgtgccccat gctgaggcgg tccgccagcc tcctggagat ccgctgtctg     2880

agagtgctgg gctgtctggg agggcagcgt gggtgtggcg gaggcaggcg tgaccgtttg     2940

ccgccctctc gctgctctag accaggtgga aactcaagcc tgcactcggg aacagaaccg     3000

catctgcacc tgcaggcccg gctggtactg cgcgctgagc aagcaggagg ggtgccggct     3060

gtgcgcgccg ctgcgcaagt gccgcccggg cttcggcgtg gccagaccag gtacggggtg     3120

gggctcaggt ccttggggac gcccatgggc ctctcctttg tagacatcct tgcagtgtca     3180

cgggcatcaa cccattaatt agtccagcag ggagcactgt tagtggtggc caggtgcctg     3240

ctacccatcc gtctgtccac ctgtccaccg ttcattcttc ctgccagcac tcccgattag     3300

gcacctctta tgtactggaa ccaggagacc cagagatgga tcagaccaag ccctaagcta     3360

ggaaagttat gtgatgctgc aagatgaact cacataactc tacagcccaa tcccgtgcat     3420

gtgtgtacag gaatctgtgt gtgtgcatgt gtgtacaggc atctgtgtgt gtgtgtgtgt     3480

gtgtgtgtgt gtgtaagggg tggaggtgca gacagagctc cttgggcccc tcagacctct     3540

cctagggctc tagtgccaag gcccagctgt cccgcagagt gtctgagtgg ttgacaagtt     3600

cggattgttc cctgaaggaa ctgaaacatc agacgtggtg tgcaagccct gtgccccggg     3660

gacgttctcc aacacgactt catccacgga tatttgcagg ccccaccaga tgtgagtagc     3720

tgagtccttt ggttctggag gagcagggag gggctgtccc tgggtgactg tgggtccagg     3780

acacagagca gctcaccaac caccattgtc cagactgctt tatctgaggg tggctcccag     3840

gataaatggc atggtgggca ggaccttgcc ctggaaggca ggactgggtg ggtgcatggg     3900

gaggtggggg agggctagga gggggtggtc ctcagagagg gcacacatcg tcactctcct     3960

atcctgcctg ctggggcccg tgaatgagcc cagccacccc agccactctg tcccctgctg     4020

cctcctgacc aagcctcctc ctcctccagc tgtaacgtgg tggccatccc tgggaatgca     4080

agcatggatg cagtctgcac gtccacgtcc cccacccgga gtatggcccc aggggcagta     4140

cacttacccc agccagtgtc cacacgatcc caacacacgc agccaactcc agaacccagc     4200

actgctccaa gcacctcctt cctgctccca atgggcccca gccccccagc tgaagggagc     4260

actggcgact tcgct                                                      4275


<210>  8
<211>  4910
<212>  DNA
<213>  Artificial sequence

<220>
<223>  The mRNA sequence of the engineered mouse TNFR2 after humanization

<400>  8
agtcaccagc tagagcgcag ctgaggcact agagctccag gcacaagggc gggagccacc       60

gctgccccta tggcgcccgc cgccctctgg gtcgcgctgg tcttcgaact gcagctgtgg      120

gccaccgggc acacagtgcc cgcccaggtt gtcttgacac cctacgcccc ggagcccggg      180

agcacatgcc ggctcagaga atactatgac cagacagctc agatgtgctg cagcaaatgc      240

tcgccgggcc aacatgcaaa agtcttctgt accaagacct cggacaccgt gtgtgactcc      300

tgtgaggaca gcacatacac ccagctctgg aactgggttc ccgagtgctt gagctgtggc      360

tcccgctgta gctctgacca ggtggaaact caagcctgca ctcgggaaca gaaccgcatc      420

tgcacctgca ggcccggctg gtactgcgcg ctgagcaagc aggaggggtg ccggctgtgc      480

gcgccgctgc gcaagtgccg cccgggcttc ggcgtggcca gaccaggaac tgaaacatca      540

gacgtggtgt gcaagccctg tgccccgggg acgttctcca acacgacttc atccacggat      600

atttgcaggc cccaccagat ctgtaacgtg gtggccatcc ctgggaatgc aagcatggat      660

gcagtctgca cgtccacgtc ccccacccgg agtatggccc caggggcagt acacttaccc      720

cagccagtgt ccacacgatc ccaacacacg cagccaactc cagaacccag cactgctcca      780

agcacctcct tcctgctccc aatgggcccc agccccccag ctgaagggag cactggcgac      840

ttcgctcttc caattggtct gattgttgga gtgacatcac tgggtctgct gatgttagga      900

ctggtgaact gcatcatcct ggtgcagagg aaaaagaagc cctcctgcct acaaagagat      960

gccaaggtgc ctcatgtgcc tgatgagaaa tcccaggatg cagtaggcct tgagcagcag     1020

cacctgttga ccacagcacc cagttccagc agcagctccc tagagagctc agccagcgct     1080

ggggaccgaa gggcgccccc tgggggccat ccccaagcaa gagtcatggc ggaggcccaa     1140

gggtttcagg aggcccgtgc cagctccagg atttcagatt cttcccacgg aagccacggg     1200

acccacgtca acgtcacctg catcgtgaac gtctgtagca gctctgacca cagttctcag     1260

tgctcttccc aagccagcgc cacagtggga gacccagatg ccaagccctc agcgtcccca     1320

aaggatgagc aggtcccctt ctctcaggag gagtgtccgt ctcagtcccc gtgtgagact     1380

acagagacac tgcagagcca tgagaagccc ttgccccttg gtgtgccgga tatgggcatg     1440

aagcccagcc aagctggctg gtttgatcag attgcagtca aagtggcctg acccctgaca     1500

ggggtaacac cctgcaaagg gacccccgag accctgaacc catggaactt catgactttt     1560

gctggatcca tttcccttag tggcttccag agccccagtt gcaggtcaag tgagggctga     1620

gacagctaga gtggtcaaaa actgccatgg tgttttatgg gggcagtccc aggaagttgt     1680

tgctcttcca tgacccctct ggatctcctg ggctcttgcc tgattcttgc ttctgagagg     1740

ccccagtatt ttttccttct aaggagctaa catcctcttc catgaatagc acagctcttc     1800

agcctgaatg ctgacactgc agggcggttc cagcaagtag gagcaagtgg tggcctggta     1860

gggcacagag gcccttcagg ttagtgctaa actcttagga agtaccctct ccaagcccac     1920

cgaaattctt ttgatgcaag aatcagaggc cccatcaggc agagttgctc tgttatagga     1980

tggtagggct gtaactcagt ggtccagtgt gcttttagca tgccctgggt ttgatcctca     2040

gcaacacatg caaaacgtaa gtagacagca gacagcagac agcacagcca gccccctgtg     2100

tggtttgcag cctctgcctt tgacttttac tctggtgggc acacagaggg ctggagctcc     2160

tcctcctgac cttctaatga gcccttccaa ggccacgcct tccttcaggg aatctcaggg     2220

actgtagagt tcccaggccc ctgcagccac ctgtctcttc ctacctcagc ctggagcact     2280

ccctctaact ccccaacggc ttggtactgt acttgctgtg accccaagtg catgtccggg     2340

ttaggcactg tgagttggaa cagctgatga catcggttga aaggcccacc cggaaacagc     2400

tgaagccagc tcttttgcca aaggattcat gccggttttc taatcaacct gctcccctag     2460

catgcctgga aggaaagggt tcaggagact cctcaagaag caagttcagt ctcaggtgct     2520

tggatgccat gctcaccgat tccactggat atgaacttgg cagaggagcc tagttgttgc     2580

catggagact taaagagctc agcactctgg aatcaagata ctggacactt ggggccgact     2640

tgttaaggct ctgcagcatc agactgtaga ggggaaggaa cacgtctgcc ccctggtggc     2700

ccgtcctggg atgacctcgg gcctcctagg caacaaaaga atgaattgga aaggactgtt     2760

cctgggtgtg gcctcagctc ctgtgcttgt gtggatccct aaagggtgtg ctaaggagca     2820

attgcactgt gtgctggaca gaattcctgc ttataaatgc tttttgttgt tgttttgtac     2880

actgagccct ggctgagcca ccccacccca cctcccatcc cacctttaca gccactcttg     2940

cagagaacct ggctgtctcc cacttgtagc ctgtggatgc tgaggaaaca cccagccaag     3000

tagactccag gcttgcccct atctcctgct ctgagtctgg cctcctcatt gtgttgtggg     3060

aaggagacgg gttctgtcat ctcggaagcc cacaccgtgg atgtgaacaa tggctgtact     3120

agcttagacc agcttagggc tctgcaatca gaggaggggg agcagggaac aatttgagtg     3180

ctgacctata acacattcct aaaggatggg cagtccagaa tctccctcct tcagtgtgtg     3240

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtccatg tttgcatgta tgtgtgtgcc     3300

agtgtgtgga ggccagaggt tggctttggg tgtgtttgat cactctcagt tactgaggca     3360

gggctctcat ctgtacccag agcttgcaca ttttctagtc taacttgctt cagggatctc     3420

tgtctgccta tggagtgctc aggttacagg caggctgcca tacctgcccg acatttacat     3480

gaatactaga gatctgaatt ctggtcctca cacttgtata cctgcatttt atccactaag     3540

acatctctcc aagggctccc ccttcctatt taataagtta gttttgaact ggcaagatgg     3600

ctcagtgggt aaggcagttt gcggacaaac ctgatgacct gagttggatc cctgaccata     3660

aggtagaaga gacctgattc ctgcaagttg tcctctgacc accaccccat acatgcttct     3720

gcatatgtgc acacatcaca ttcttgcaca cacactcaca taccataaat gtaataaatt     3780

tttttaaata aattgatttt atcttttaat cattattttt gcttatctgt ttgttcatac     3840

atggagtttt gctgtatacc cagtctggct gcatcctcca ggcaccttga acttggatat     3900

tctcctgcct cagtttcgag agtgctgagt tataggcatg tgcaaccgtg tcaggaccct     3960

tggcgttaca ttatgttttc gaatcttatt tttccatcta agactgacaa ccaccttgcc     4020

aaaggatgac cttgactttt gtatcctctt gcctctactt cccaagtatt gggatgacaa     4080

gtctgtccat cctatgattt gtgtggtgct ggggcttgaa cccaggggcc tcgtgaatgc     4140

taggcaaacg caatcagctg cccaaccccg aacttcactt ttcacctgtg atttcttaac     4200

atggttcctg agcagacagc atgatcctgt tgccttgagg agctctgctc gttgctttga     4260

caatgctcta tttactaaag aatacttata gagttcaaga ctccaaagca gcagttccca     4320

acctgtgggt atgacctctt gggtatccca tatcagatat ttacattaaa cttataacag     4380

aagcaaaatt acagttatgg ggtagcaaca aaataatttt tttttgaggc agggtttatc     4440

tgtgtagctc actttgtaca gactaggctg gccttgaact taaagatctg cctgcctctg     4500

ccttctgaat gctgggatta aatgtgtgtg ccaacatgcc cagtgcagtg aaataatttt     4560

attgttgggt caccaaaaca tgagaaagag tattaaaagg tcatagcgtt aggaaggttg     4620

agaaccactg ccccaaaaga tagtagaaat aggtaatagc attttaaaaa aagattaatt     4680

tctttttccg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg     4740

tgtgaagggt gctgaattcc ctaaatctgg gattacagac aattgtgcca aatgggtatt     4800

gggaaccaaa gttgggtttt ctgaaagagc agcaagtgcc cttaactgct gagccctctc     4860

tctagctata ataaactttt ttttaaaaaa attaaaaaaa tttagcactc                4910


<210>  9
<211>  473
<212>  PRT
<213>  Artificial sequence

<220>
<223>  encoded protein sequence of the engineered mouse TNFR2 after humanization

<400>  9

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Phe Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Gln Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Ile Gly Leu Ile Val Gly Val Thr Ser Leu Gly 
            260                 265                 270         


Leu Leu Met Leu Gly Leu Val Asn Cys Ile Ile Leu Val Gln Arg Lys 
        275                 280                 285             


Lys Lys Pro Ser Cys Leu Gln Arg Asp Ala Lys Val Pro His Val Pro 
    290                 295                 300                 


Asp Glu Lys Ser Gln Asp Ala Val Gly Leu Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg Val 
            340                 345                 350         


Met Ala Glu Ala Gln Gly Phe Gln Glu Ala Arg Ala Ser Ser Arg Ile 
        355                 360                 365             


Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr Cys 
    370                 375                 380                 


Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser 
385                 390                 395                 400 


Gln Ala Ser Ala Thr Val Gly Asp Pro Asp Ala Lys Pro Ser Ala Ser 
                405                 410                 415     


Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser Gln 
            420                 425                 430         


Ser Pro Cys Glu Thr Thr Glu Thr Leu Gln Ser His Glu Lys Pro Leu 
        435                 440                 445             


Pro Leu Gly Val Pro Asp Met Gly Met Lys Pro Ser Gln Ala Gly Trp 
    450                 455                 460                 


Phe Asp Gln Ile Ala Val Lys Val Ala 
465                 470             


<210>  10
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the mouse TNFR2 gene locus

<400>  10
tccctttggg cagaactggg gcctggtctc tgtcttttag aacggaattc cgaagttcct       60

attctctaga                                                              70


<210>  11
<211>  70
<212>  DNA
<213>  Artificial sequence

<220>
<223>  connection between the 3' end of the Neo cassette with the mouse TNFR2 gene locus

<400>  11
aggaacttca tcagtcaggt acataatggt ggatcccata tgagatgcaa gtgtagaaga       60

gttgagtctc                                                              70


<210>  12
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  12
ctcgactgtg ccttctagtt gccag                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  13
cctaacctct cttggtgctg agaac                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  14
gatcagtgag acagtccaac ttggc                                             25


<210>  15
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  15
gcatgggcca gtgcatagaa ctag                                              24


<210>  16
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  16
tgatggtggg atgagtctga agaag                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  17
gaatgcctca ccctctctgc tatta                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  18
acctcgagtc agacttctgt aggta                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  19
ctagggatat aagcagaacg tggct                                             25


<210>  20
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  20
ggatcggcca ttgaacaaga tgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  probe

<400>  21
cagaagaact cgtcaagaag gcg                                               23


<210>  22
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  22
tatgctggag cccagagtca tactg                                             25


<210>  23
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  23
ggacatcatt gcagtattga ggagg                                             25


<210>  24
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  24
gcatgggcca gtgcatagaa ctag                                              24


<210>  25
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  25
tacttttaat gggagctgag gctgt                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  26
atagtctgtg agacaaacgg gttca                                             25


<210>  27
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  27
gacaagcgtt agtaggcaca tatac                                             25


<210>  28
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer

<400>  28
gctccaattt cccacaacat tagt                                              24


<210>  29
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  connection between the 3'end of the human TNFR2 gene sequence and the mouse TNFR2 gene locus

<400>  29
ggccccagcc ccccagctga agggagcact ggcgacttcg ctcttccaat tggtaagtcc       60

tcagtctcaa gagtgacc                                                     78


<210>  30
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer 

<400>  30
gcctacaaag agatgccaag gtg                                               23


<210>  31
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer 

<400>  31
tctgaaatcc tggagctggc ac                                                22


<210>  32
<211>  474
<212>  PRT
<213>  Mus. musculus

<400>  32

Met Ala Pro Ala Ala Leu Trp Val Ala Leu Val Val Glu Leu Gln Leu 
1               5                   10                  15      


Trp Ala Thr Gly His Thr Val Pro Ala Lys Val Val Leu Thr Pro Tyr 
            20                  25                  30          


Lys Pro Glu Pro Gly Asn Gln Cys Gln Ile Ser Gln Glu Tyr Tyr Asp 
        35                  40                  45              


Lys Lys Ala Gln Met Cys Cys Ala Lys Cys Pro Pro Gly Gln Tyr Ala 
    50                  55                  60                  


Lys His Phe Cys Asn Lys Thr Ser Asp Thr Val Cys Ala Asp Cys Ala 
65                  70                  75                  80  


Ala Gly Met Phe Thr Gln Val Trp Asn His Leu His Thr Cys Leu Ser 
                85                  90                  95      


Cys Ser Ser Ser Cys Ser Asp Asp Gln Val Glu Thr His Asn Cys Thr 
            100                 105                 110         


Lys Lys Gln Asn Arg Val Cys Ala Cys Asn Ala Asp Ser Tyr Cys Ala 
        115                 120                 125             


Leu Lys Leu His Ser Gly Asn Cys Arg Gln Cys Met Lys Leu Ser Lys 
    130                 135                 140                 


Cys Gly Pro Gly Phe Gly Val Ala Arg Ser Arg Thr Ser Asn Gly Asn 
145                 150                 155                 160 


Val Ile Cys Ser Ala Cys Ala Pro Gly Thr Phe Ser Asp Thr Thr Ser 
                165                 170                 175     


Ser Thr Asp Val Cys Arg Pro His Arg Ile Cys Ser Ile Leu Ala Ile 
            180                 185                 190         


Pro Gly Asn Ala Ser Thr Asp Ala Val Cys Ala Ser Glu Ser Pro Thr 
        195                 200                 205             


Pro Ser Ala Val Pro Arg Thr Ile Tyr Val Ser Gln Pro Glu Pro Thr 
    210                 215                 220                 


Arg Ser Gln Pro Met Asp Gln Glu Pro Gly Pro Ser Gln Thr Pro His 
225                 230                 235                 240 


Ile Pro Val Ser Leu Gly Ser Thr Pro Ile Ile Glu Pro Ser Ile Thr 
                245                 250                 255     


Gly Gly Ile Ser Leu Pro Ile Gly Leu Ile Val Gly Leu Thr Thr Leu 
            260                 265                 270         


Gly Leu Leu Met Leu Gly Leu Ala Asn Cys Phe Ile Leu Val Gln Arg 
        275                 280                 285             


Lys Lys Lys Pro Ser Cys Leu Gln Arg Glu Thr Met Val Pro His Leu 
    290                 295                 300                 


Pro Asp Asp Lys Ser Gln Asp Ala Ile Gly Leu Glu Gln Gln His Leu 
305                 310                 315                 320 


Leu Thr Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala 
                325                 330                 335     


Ser Ala Gly Asp Arg Arg Ala Pro Pro Gly Gly His Pro Gln Ala Arg 
            340                 345                 350         


Val Thr Ala Glu Ala Gln Gly Ser Gln Glu Ala Cys Ala Gly Ser Arg 
        355                 360                 365             


Ser Ser Asp Ser Ser His Gly Ser His Gly Thr His Val Asn Val Thr 
    370                 375                 380                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
385                 390                 395                 400 


Ser Gln Ala Ser Thr Thr Val Gly Asp Pro Asp Ala Asn Pro Ser Gly 
                405                 410                 415     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Gln Glu Glu Cys Pro Ser 
            420                 425                 430         


Gln Ser Gln Trp Glu Thr Thr Glu Thr Leu Gln Asn His Asp Lys Pro 
        435                 440                 445             


Phe Pro Leu Gly Val Pro Asp Val Gly Met Lys Pro Asn Gln Pro Gly 
    450                 455                 460                 


Trp Tyr Asp Gln Ile Ala Val Lys Val Pro 
465                 470                 


