                         SEQUENCE LISTING

<110>  BIOSION INC.
       CHIA TAI TIANQING PHARMACEUTICALS GROUP CO., LTD.
 
<120>  ANTIBODIES BINDING TSLP AND USES THEREOF

<130>  55532 00020

<150>  US62/895,984
<151>  2019-09-04

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for mouse, chimeric and humanized 1C5F12E9 antibodies

<400>  1

Thr Tyr Trp Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for mouse, chimeric and humanized 1C5F12E9 antibodies

<400>  2

Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for mouse, chimeric and humanized 1C5F12E9 antibodies

<400>  3

Ser Leu Asp Gly Tyr Tyr Asp Tyr 
1               5               


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for mouse, chimeric and humanized 1C5F12E9 antibodies

<400>  4

Arg Pro Thr Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for mouse, chimeric and humanized 1C5F12E9 antibodies

<400>  5

Phe Ala Arg Thr Leu Ala Glu 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for mouse, chimeric and humanized 1C5F12E9 antibodies

<400>  6

Gln His His Tyr Gly Thr Pro Trp Thr 
1               5                   


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse and chimeric 1C5F12E9 antibodies

<400>  7

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Leu Asp Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for hu1C5F12E9-V1, hu1C5F12E9-V7, and hu1C5F12E9-V13

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Leu Asp Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for hu1C5F12E9-V2 to hu1C5F12E9-V6, hu1C5F12E9-V8 to 
       hu1C5F12E9-V12, and hu1C5F12E9-V14 to hu1C5F12E9-V18


<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be Arg or Lys

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa can be Val or Ala

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be Arg or Val

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Ser Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Xaa Xaa Thr Met Thr Xaa Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Leu Asp Gly Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse and chimeric 1C5F12E9 antibodies

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Pro Thr Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Phe Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ile Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for hu1C5F12E9-V1 to hu1C5F12E9-V18


<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can Ser or Ala

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be Val or Ile

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Pro Thr Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Xaa 
        35                  40                  45              


Tyr Phe Ala Arg Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 heavy chain constant region

<400>  13

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human kappa light chain constant region

<400>  14

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  15
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IgG1 heavy chain constant region

<400>  15

Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
1               5                   10                  15      


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
65                  70                  75                  80  


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
            100                 105                 110         


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
        115                 120                 125             


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
    130                 135                 140                 


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
145                 150                 155                 160 


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                165                 170                 175     


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
    210                 215                 220                 


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
225                 230                 235                 240 


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
                245                 250                 255     


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
            260                 265                 270         


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
        275                 280                 285             


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
    290                 295                 300                 


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  16
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse kappa light chain constant region

<400>  16

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  17
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for mouse and chimeric 1C5F12E9 antibodies

<400>  17
caggtccaac tgcagcagcc tgggactgag ctggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta caccttcacc acctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gatcggagtg attgatcctt ctgatagtga tactacctac      180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtac aaggtccctt      300

gatggttact acgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  18
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for mouse and chimeric 1C5F12E9 antibodies

<400>  18
caggtgcagc tgcagcagcc cggcaccgag ctggtgaagc ctggcgctag cgtgaagatg       60

tcctgtaagg ccagcggcta cacattcact acatactgga tgcactgggt gaagcagaga      120

cctggccagg gcctggagtg gatcggcgtg atcgacccca gcgactccga taccacctac      180

aaccagaagt ttaagggcaa ggccaccctg acagtggata caagctcctc cacagcctac      240

atgcagctgt ccagcctgac ctccgaggat tccgccgtgt actactgcac aaggtccctg      300

gatggctact acgattactg gggccagggc acaaccctga cagtcagcag c               351


<210>  19
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for hu1C5F12E9-V2, hu1C5F12E9-V8, and hu1C5F12E9-V14

<400>  19
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ctggcgcctc cgtgaaggtg       60

tcctgcaagg ccagcggcta cacattcacc acatactgga tgcactgggt gagacaggcc      120

cccggccagg gactggagtg gatgggagtg atcgacccca gcgactccga cacaacctac      180

aaccagaagt tcaagggcag ggtgacaatg accagagaca ccagcacaag caccgtgtac      240

atggagctgt cctccctgag gagcgaggac accgccgtgt actactgcac cagatccctg      300

gacggctact acgactactg gggccagggc accctggtga cagtgtccag c               351


<210>  20
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for mouse and chimeric 1C5F12E9 antibodies

<400>  20
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gaccaactga gaatatttac agttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcacctcct ggtctatttt gcaagaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggatttatta ctgtcaacac cattatggta ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  21
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for mouse and chimeric 1C5F12E9 antibodies

<400>  21
gacatccaga tgacccagtc ccccgccagc ctgtccgcct ctgtgggaga gaccgtgacc       60

atcacatgca ggcccaccga gaatatctac tcctacctgg cctggtatca acagaagcag      120

ggcaagagcc ctcacctgct ggtgtacttc gccaggacac tggccgaggg cgtgccctct      180

aggttcagcg gcagcggctc cggcacacag ttttccctga agatcaacag cctgcagcct      240

gaggattttg gcatctacta ctgccagcac cactacggca caccctggac ctttggcggc      300

ggcaccaagc tggagatcaa g                                                321


<210>  22
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for hu1C5F12E9-V7 - hu1C5F12E9-V12

<400>  22
gatatccaga tgacacagag ccccagcagc ctgagcgcca gcgtgggaga cagggtgaca       60

atcacatgca gacccaccga gaatatctac agctacctgg cctggtatca acagaagcct      120

ggcaaggccc ccaagctgct gatctacttc gccagaaccc tggccgaggg cgtgccctct      180

aggttcagcg gctccggcag cggcaccgac ttcacactga ccatctcctc cctgcagccc      240

gaggacttcg ccacatacta ctgccagcac cactacggca caccttggac cttcggcggc      300

ggcacaaagg tggagatcaa g                                                321


<210>  23
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region

<400>  23
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210>  24
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG4 heavy chain constant region

<400>  24
gccagcacaa agggcccttc cgtgtttccc ctggccccct gcagcaggag cacctctgag       60

tccaccgccg ccctgggctg tctggtgaag gactactttc ccgagcccgt gaccgtgagc      120

tggaattccg gcgccctgac atccggcgtg cacaccttcc ccgccgtgct gcagtcctcc      180

ggcctgtaca gcctgagctc cgtggtgaca gtgccttcct cctccctggg caccaagacc      240

tacacatgta atgtggatca caagcccagc aacacaaagg tggataagag agtggagtcc      300

aagtacggcc ctccttgccc tccctgtcct gccccagagt tcctgggcgg cccctctgtg      360

ttcctgttcc cccctaagcc caaggacaca ctgatgatct ccaggacccc tgaggtgacc      420

tgcgtggtgg tggacgtgag ccaggaggac cctgaggtgc agttcaattg gtacgtggat      480

ggcgtggagg tgcacaatgc caagacaaag cccagagagg agcagtttaa ttccacatac      540

agggtggtgt ccgtgctgac cgtgctgcac caggattggc tgaacggcaa ggagtacaag      600

tgtaaggtga gcaacaaggg cctgccttcc tccatcgaga agacaatcag caaggccaag      660

ggccagccta gggagcccca ggtgtacaca ctgcctccca gccaggagga gatgaccaag      720

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ctagcgacat cgccgtggag      780

tgggagtcca acggccagcc cgagaataac tacaagacaa caccccccgt gctggattcc      840

gatggcagct tctttctgta ctccaggctg accgtggata agagcaggtg gcaggagggc      900

aatgtgttca gctgctccgt gatgcacgag gccctgcaca atcactacac ccagaagagc      960

ctgtccctga gcctgggcaa gtga                                             984


<210>  25
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human kappa light chain constant region

<400>  25
cgtacggtgg cggcgccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttga                                             324


<210>  26
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse IgG1 heavy chain constant region

<400>  26
gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac       60

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      120

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac      180

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc      240

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      300

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      360

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      420

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      480

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc      540

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc      600

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg      660

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc      720

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg      780

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct      840

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc      900

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac      960

tctcctggta aatga                                                       975


<210>  27
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse kappa light chain constant region

<400>  27
cgggctgatg ctgcaccaac tgtatccatc ttcccaccat ccagtgagca gttaacatct       60

ggaggtgcct cagtcgtgtg cttcttgaac aacttctacc ccaaagacat caatgtcaag      120

tggaagattg atggcagtga acgacaaaat ggcgtcctga acagttggac tgatcaggac      180

agcaaagaca gcacctacag catgagcagc accctcacgt tgactaagga cgagtatgaa      240

cgacataaca gctatacctg tgaggccact cacaagacat caacttcacc cattgtcaag      300

agcttcaaca ggggagagtg t                                                321


<210>  28
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant human TSLP-his

<400>  28

Tyr Asp Phe Thr Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu 
1               5                   10                  15      


Ser Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser 
            20                  25                  30          


Thr Glu Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu 
        35                  40                  45              


Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser 
    50                  55                  60                  


Leu Ala Lys Glu Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile 
65                  70                  75                  80  


Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met 
                85                  90                  95      


Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln 
            100                 105                 110         


Val Ser Gln Leu Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu 
        115                 120                 125             


Lys Gln Gln His His His His His His His His His His 
    130                 135                 140     


<210>  29
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant cynomolgus monkey TSLP-his

<400>  29

Met Tyr Asp Phe Thr Asn Cys Asp Phe Gln Lys Ile Glu Ala Asp Tyr 
1               5                   10                  15      


Leu Arg Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys 
            20                  25                  30          


Ser Thr Asp Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys 
        35                  40                  45              


Leu Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Pro Arg Cys Ala 
    50                  55                  60                  


Ser Leu Ala Lys Glu Met Phe Ala Arg Lys Thr Lys Ala Thr Leu Ala 
65                  70                  75                  80  


Leu Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala 
                85                  90                  95      


Met Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu 
            100                 105                 110         


Gln Val Ser Gln Leu Leu Gly Leu Trp Arg Arg Phe Ile Arg Thr Leu 
        115                 120                 125             


Leu Lys Lys Gln Leu Glu His His His His His His 
    130                 135                 140 


<210>  30
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human TSLPR-Fc

<400>  30

Gly Ala Ala Glu Gly Val Gln Ile Gln Ile Ile Tyr Phe Asn Leu Glu 
1               5                   10                  15      


Thr Val Gln Val Thr Trp Asn Ala Ser Lys Tyr Ser Arg Thr Asn Leu 
            20                  25                  30          


Thr Phe His Tyr Arg Phe Asn Gly Asp Glu Ala Tyr Asp Gln Cys Thr 
        35                  40                  45              


Asn Tyr Leu Leu Gln Glu Gly His Thr Ser Gly Cys Leu Leu Asp Ala 
    50                  55                  60                  


Glu Gln Arg Asp Asp Ile Leu Tyr Phe Ser Ile Arg Asn Gly Thr His 
65                  70                  75                  80  


Pro Val Phe Thr Ala Ser Arg Trp Met Val Tyr Tyr Leu Lys Pro Ser 
                85                  90                  95      


Ser Pro Lys His Val Arg Phe Ser Trp His Gln Asp Ala Val Thr Val 
            100                 105                 110         


Thr Cys Ser Asp Leu Ser Tyr Gly Asp Leu Leu Tyr Glu Val Gln Tyr 
        115                 120                 125             


Arg Ser Pro Phe Asp Thr Glu Trp Gln Ser Lys Gln Glu Asn Thr Cys 
    130                 135                 140                 


Asn Val Thr Ile Glu Gly Leu Asp Ala Glu Lys Cys Tyr Ser Phe Trp 
145                 150                 155                 160 


Val Arg Val Lys Ala Met Glu Asp Val Tyr Gly Pro Asp Thr Tyr Pro 
                165                 170                 175     


Ser Asp Trp Ser Glu Val Thr Cys Trp Gln Arg Gly Glu Ile Arg Asp 
            180                 185                 190         


Ala Cys Ala Glu Thr Pro Thr Pro Pro Lys Pro Lys Leu Ser Lys Asp 
        195                 200                 205             


Ile Glu Gly Arg Met Asp Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  31
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL7Ra-Fc

<400>  31

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  32
<211>  363
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human TSLP-Fc

<400>  32

Tyr Asp Phe Thr Asn Cys Asp Phe Glu Lys Ile Lys Ala Ala Tyr Leu 
1               5                   10                  15      


Ser Thr Ile Ser Lys Asp Leu Ile Thr Tyr Met Ser Gly Thr Lys Ser 
            20                  25                  30          


Thr Glu Phe Asn Asn Thr Val Ser Cys Ser Asn Arg Pro His Cys Leu 
        35                  40                  45              


Thr Glu Ile Gln Ser Leu Thr Phe Asn Pro Thr Ala Gly Cys Ala Ser 
    50                  55                  60                  


Leu Ala Lys Glu Met Phe Ala Met Lys Thr Lys Ala Ala Leu Ala Ile 
65                  70                  75                  80  


Trp Cys Pro Gly Tyr Ser Glu Thr Gln Ile Asn Ala Thr Gln Ala Met 
                85                  90                  95      


Lys Lys Arg Arg Lys Arg Lys Val Thr Thr Asn Lys Cys Leu Glu Gln 
            100                 105                 110         


Val Ser Gln Leu Gln Gly Leu Trp Arg Arg Phe Asn Arg Pro Leu Leu 
        115                 120                 125             


Lys Gln Gln Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
    130                 135                 140                 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
145                 150                 155                 160 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                165                 170                 175     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            180                 185                 190         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        195                 200                 205             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    210                 215                 220                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
225                 230                 235                 240 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                245                 250                 255     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            260                 265                 270         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        275                 280                 285             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    290                 295                 300                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
305                 310                 315                 320 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                325                 330                 335     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            340                 345                 350         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360             


<210>  33
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Arg Leu Val Leu Leu Trp Gly Ala Ala Val Phe Leu Leu Gly 
1               5                   10                  15      


Gly Trp Met Ala Leu Gly Gln Gly Gly Ala Ala Glu Gly Val Gln Ile 
            20                  25                  30          


Gln Ile Ile Tyr Phe Asn Leu Glu Thr Val Gln Val Thr Trp Asn Ala 
        35                  40                  45              


Ser Lys Tyr Ser Arg Thr Asn Leu Thr Phe His Tyr Arg Phe Asn Gly 
    50                  55                  60                  


Asp Glu Ala Tyr Asp Gln Cys Thr Asn Tyr Leu Leu Gln Glu Gly His 
65                  70                  75                  80  


Thr Ser Gly Cys Leu Leu Asp Ala Glu Gln Arg Asp Asp Ile Leu Tyr 
                85                  90                  95      


Phe Ser Ile Arg Asn Gly Thr His Pro Val Phe Thr Ala Ser Arg Trp 
            100                 105                 110         


Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 
        115                 120                 125             


Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 
    130                 135                 140                 


Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 
145                 150                 155                 160 


Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 
                165                 170                 175     


Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 
            180                 185                 190         


Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 
        195                 200                 205             


Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 
    210                 215                 220                 


Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 
225                 230                 235                 240 


Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 
                245                 250                 255     


Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 
            260                 265                 270         


Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 
        275                 280                 285             


Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 
    290                 295                 300                 


Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 
305                 310                 315                 320 


Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 
                325                 330                 335     


Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 
            340                 345                 350         


Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 
        355                 360                 365             


Val Ala Leu 
    370     


<210>  34
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Val Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  35
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of Tezepelumab

<400>  35

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ser Lys Asn Thr Leu Asn 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Gln Trp Glu Leu Val His Glu Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of Tezepelumab

<400>  36

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Leu Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Trp Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Gly Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for mouse antibody D1D8H9F7

<400>  37

Ser Tyr Tyr Met Asn 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for mouse antibody D1D8H9F7

<400>  38

Gln Ile Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for mouse antibody D1D8H9F7

<400>  39

Ala Gly Tyr Ser Asp Tyr Val Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for mouse antibody D1D8H9F7

<400>  40

Ser Val Ser Ser Ser Ile Thr Ser Ser Asn Leu His 
1               5                   10          


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for mouse antibody D1D8H9F7

<400>  41

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for mouse antibody D1D8H9F7

<400>  42

Gln Gln Trp Ser Ser Phe Pro Leu 
1               5               


<210>  43
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse antibody D1D8H9F7

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Gly Tyr Ser Asp Tyr Val Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  44
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse antibody D1D8H9F7

<400>  44

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ile Cys Ser Val Ser Ser Ser Ile Thr Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Phe Pro 
                85                  90                  95      


Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  45
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for mouse antibody D1D8H9F7

<400>  45
caggttcagc tgcagcagtc tggggctgac ctggtgaggc ctgggtcctc agtgaagatt       60

tcctgcaaga cttctggctt tgcattcagt agctactata tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacag atttatcctg gagatggtga aactaactac      180

aatggaaagt tcaaggataa agccacactg actgcagaca aatcctccag cacagtctac      240

atgcagctca gcagcctaac atctgaggac tctgcggtct acttctgtgc aagagcgggt      300

tatagtgact acgtttatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  46
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for mouse antibody D1D8H9F7

<400>  46
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcatctgca gtgtcagctc aagtataact tccagcaacc tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gtttcccact cacgttcggc      300

tcggggacaa agttggaaat aaaa                                             324


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR1 for mouse antibody D1C2H1H1

<400>  47

Thr Tyr Gly Met Gly Ile Gly 
1               5           


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR2 for mouse antibody D1C2H1H1

<400>  48

Ser Ile Trp Trp Asp Asp Asn Arg Tyr Phe Asn Ala Ala Leu Lys Ser 
1               5                   10                  15      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH-CDR3 for mouse antibody D1C2H1H1

<400>  49

Ile Glu Asp Gly Tyr Tyr Ser Tyr His Ser Tyr 
1               5                   10      


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR1 for mouse antibody D1C2H1H1

<400>  50

Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR2 for mouse antibody D1C2H1H1

<400>  51

Ala Ala Ser Asn Leu Val Ser 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL-CDR3 for mouse antibody D1C2H1H1

<400>  52

Gln Gln Ile Asp Glu Asp Pro Tyr Thr 
1               5                   


<210>  53
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH for mouse antibody D1C2H1H1

<400>  53

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Ile Gly Trp Ile Arg Leu Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Ser Ile Trp Trp Asp Asp Asn Arg Tyr Phe Asn Ala Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ala Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Glu Asp Gly Tyr Tyr Ser Tyr His Ser Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  54
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL for mouse antibody D1C2H1H1

<400>  54

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Val Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ile Asp 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110     


<210>  55
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH for mouse antibody D1C2H1H1

<400>  55
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttatggca tgggtatagg ctggattcgt      120

ctgccttcgg ggaagggtct ggagtggctg gcaagcattt ggtgggatga taatagatac      180

tttaacgctg ccctgaagag ccggctcact atctccaagg atgcctccaa aaaccaggta      240

ttcctcaaga tcgccagtgt ggacactgca gatactgcca catattattg tgctcgaata      300

gaggacggct attatagtta tcactcttac tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  56
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL for mouse antibody D1C2H1H1

<400>  56
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tttgatggtg atagttatat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagtatct      180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaattgatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata gaa                                   333

<210>  57
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region

<400>  57

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  58
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 heavy chain constant region

<400>  58
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


