                         SEQUENCE LISTING

<110>  Research Institute at Nationwide Children's Hospital
 
<120>  COPPER-ATSM FOR METHODS OF TREATMENT

<130>  28335/54510/PC

<150>  US 62/894,622
<151>  2019-08-30

<150>  US 62/943,131
<151>  2019-12-03

<150>  US 63/062,945
<151>  2020-08-07

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2005
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  2
<211>  8776
<212>  DNA
<213>  Homo Sapeins

<400>  2
aacagacatt gggtaccatc gaatgactgt cagaacagaa agctaaggca aaggagggag       60

gatgctgtgg tcatcctttc ttgttttttt cttctttaat gaggatagag cacatgtgag      120

attttacttt ctactccagt aaaaattctg aagaattgca ttggagactg ttatattcaa      180

cacatacgtg gattctgtgt tatgatttac atttttcttt atttcagcac tttcttatgc      240

aaggagctaa acagtgatta aaggagcagg atgaaaagat ggcacagtca gtgctggtac      300

cgccaggacc tgacagcttc cgcttcttta ccagggaatc ccttgctgct attgaacaac      360

gcattgcaga agagaaagct aagagaccca aacaggaacg caaggatgag gatgatgaaa      420

atggcccaaa gccaaacagt gacttggaag caggaaaatc tcttccattt atttatggag      480

acattcctcc agagatggtg tcagtgcccc tggaggatct ggacccctac tatatcaata      540

agaaaacgtt tatagtattg aataaaggga aagcaatctc tcgattcagt gccacccctg      600

ccctttacat tttaactccc ttcaacccta ttagaaaatt agctattaag attttggtac      660

attctttatt caatatgctc attatgtgca cgattcttac caactgtgta tttatgacca      720

tgagtaaccc tccagactgg acaaagaatg tggagtatac ctttacagga atttatactt      780

ttgaatcact tattaaaata cttgcaaggg gcttttgttt agaagatttc acatttttac      840

gggatccatg gaattggttg gatttcacag tcattacttt tgcatatgtg acagagtttg      900

tggacctggg caatgtctca gcgttgagaa cattcagagt tctccgagca ttgaaaacaa      960

tttcagtcat tccaggcctg aagaccattg tgggggccct gatccagtca gtgaagaagc     1020

tttctgatgt catgatcttg actgtgttct gtctaagcgt gtttgcgcta ataggattgc     1080

agttgttcat gggcaaccta cgaaataaat gtttgcaatg gcctccagat aattcttcct     1140

ttgaaataaa tatcacttcc ttctttaaca attcattgga tgggaatggt actactttca     1200

ataggacagt gagcatattt aactgggatg aatatattga ggataaaagt cacttttatt     1260

ttttagaggg gcaaaatgat gctctgcttt gtggcaacag ctcagatgca ggccagtgtc     1320

ctgaaggata catctgtgtg aaggctggta gaaaccccaa ctatggctac acgagctttg     1380

acacctttag ttgggccttt ttgtccttat ttcgtctcat gactcaagac ttctgggaaa     1440

acctttatca actgacacta cgtgctgctg ggaaaacgta catgatattt tttgtgctgg     1500

tcattttctt gggctcattc tatctaataa atttgatctt ggctgtggtg gccatggcct     1560

atgaggaaca gaatcaggcc acattggaag aggctgaaca gaaggaagct gaatttcagc     1620

agatgctcga acagttgaaa aagcaacaag aagaagctca ggcggcagct gcagccgcat     1680

ctgctgaatc aagagacttc agtggtgctg gtgggatagg agttttttca gagagttctt     1740

cagtagcatc taagttgagc tccaaaagtg aaaaagagct gaaaaacaga agaaagaaaa     1800

agaaacagaa agaacagtct ggagaagaag agaaaaatga cagagtccga aaatcggaat     1860

ctgaagacag cataagaaga aaaggtttcc gtttttcctt ggaaggaagt aggctgacat     1920

atgaaaagag attttcttct ccacaccagt ccttactgag catccgtggc tcccttttct     1980

ctccaagacg caacagtagg gcgagccttt tcagcttcag aggtcgagca aaggacattg     2040

gctctgagaa tgactttgct gatgatgagc acagcacctt tgaggacaat gacagccgaa     2100

gagactctct gttcgtgccg cacagacatg gagaacggcg ccacagcaat gtcagccagg     2160

ccagccgtgc ctccagggtg ctccccatcc tgcccatgaa tgggaagatg catagcgctg     2220

tggactgcaa tggtgtggtc tccctggtcg ggggcccttc taccctcaca tctgctgggc     2280

agctcctacc agagggcaca actactgaaa cagaaataag aaagagacgg tccagttctt     2340

atcatgtttc catggattta ttggaagatc ctacatcaag gcaaagagca atgagtatag     2400

ccagtatttt gaccaacacc atggaagaac ttgaagaatc cagacagaaa tgcccaccat     2460

gctggtataa atttgctaat atgtgtttga tttgggactg ttgtaaacca tggttaaagg     2520

tgaaacacct tgtcaacctg gttgtaatgg acccatttgt tgacctggcc atcaccatct     2580

gcattgtctt aaatacactc ttcatggcta tggagcacta tcccatgacg gagcagttca     2640

gcagtgtact gtctgttgga aacctggtct tcacagggat cttcacagca gaaatgtttc     2700

tcaagataat tgccatggat ccatattatt actttcaaga aggctggaat atttttgatg     2760

gttttattgt gagccttagt ttaatggaac ttggtttggc aaatgtggaa ggattgtcag     2820

ttctccgatc attccggctg ctccgagttt tcaagttggc aaaatcttgg ccaactctaa     2880

atatgctaat taagatcatt ggcaattctg tgggggctct aggaaacctc accttggtat     2940

tggccatcat cgtcttcatt tttgctgtgg tcggcatgca gctctttggt aagagctaca     3000

aagaatgtgt ctgcaagatt tccaatgatt gtgaactccc acgctggcac atgcatgact     3060

ttttccactc cttcctgatc gtgttccgcg tgctgtgtgg agagtggata gagaccatgt     3120

gggactgtat ggaggtcgct ggccaaacca tgtgccttac tgtcttcatg atggtcatgg     3180

tgattggaaa tctagtggtt ctgaacctct tcttggcctt gcttttgagt tccttcagtt     3240

ctgacaatct tgctgccact gatgatgata acgaaatgaa taatctccag attgctgtgg     3300

gaaggatgca gaaaggaatc gattttgtta aaagaaaaat acgtgaattt attcagaaag     3360

cctttgttag gaagcagaaa gctttagatg aaattaaacc gcttgaagat ctaaataata     3420

aaaaagacag ctgtatttcc aaccatacca ccatagaaat aggcaaagac ctcaattatc     3480

tcaaagacgg aaatggaact actagtggca taggcagcag tgtagaaaaa tatgtcgtgg     3540

atgaaagtga ttacatgtca tttataaaca accctagcct cactgtgaca gtaccaattg     3600

ctgttggaga atctgacttt gaaaatttaa atactgaaga attcagcagc gagtcagata     3660

tggaggaaag caaagagaag ctaaatgcaa ctagttcatc tgaaggcagc acggttgata     3720

ttggagctcc cgccgaggga gaacagcctg aggttgaacc tgaggaatcc cttgaacctg     3780

aagcctgttt tacagaagac tgtgtacgga agttcaagtg ttgtcagata agcatagaag     3840

aaggcaaagg gaaactctgg tggaatttga ggaaaacatg ctataagata gtggagcaca     3900

attggttcga aaccttcatt gtcttcatga ttctgctgag cagtggggct ctggcctttg     3960

aagatatata cattgagcag cgaaaaacca ttaagaccat gttagaatat gctgacaagg     4020

ttttcactta catattcatt ctggaaatgc tgctaaagtg ggttgcatat ggttttcaag     4080

tgtattttac caatgcctgg tgctggctag acttcctgat tgttgatgtc tcactggtta     4140

gcttaactgc aaatgccttg ggttactcag aacttggtgc catcaaatcc ctcagaacac     4200

taagagctct gaggccactg agagctttgt cccggtttga aggaatgagg gttgttgtaa     4260

atgctctttt aggagccatt ccatctatca tgaatgtact tctggtttgt ctgatctttt     4320

ggctaatatt cagtatcatg ggagtgaatc tctttgctgg caagttttac cattgtatta     4380

attacaccac tggagagatg tttgatgtaa gcgtggtcaa caactacagt gagtgcaaag     4440

ctctcattga gagcaatcaa actgccaggt ggaaaaatgt gaaagtaaac tttgataacg     4500

taggacttgg atatctgtct ctacttcaag tagccacgtt taagggatgg atggatatta     4560

tgtatgcagc tgttgattca cgaaatgtag aattacaacc caagtatgaa gacaacctgt     4620

acatgtatct ttattttgtc atctttatta tttttggttc attctttacc ttgaatcttt     4680

tcattggtgt catcatagat aacttcaacc aacagaaaaa gaagtttgga ggtcaagaca     4740

tttttatgac agaagaacag aagaaatact acaatgcaat gaaaaaactg ggttcaaaga     4800

aaccacaaaa acccatacct cgacctgcta acaaattcca aggaatggtc tttgattttg     4860

taaccaaaca agtctttgat atcagcatca tgatcctcat ctgccttaac atggtcacca     4920

tgatggtgga aaccgatgac cagagtcaag aaatgacaaa cattctgtac tggattaatc     4980

tggtgtttat tgttctgttc actggagaat gtgtgctgaa actgatctct cttcgttact     5040

actatttcac tattggatgg aatatttttg attttgtggt ggtcattctc tccattgtag     5100

gaatgtttct ggctgaactg atagaaaagt attttgtgtc ccctaccctg ttccgagtga     5160

tccgtcttgc caggattggc cgaatcctac gtctgatcaa aggagcaaag gggatccgca     5220

cgctgctctt tgctttgatg atgtcccttc ctgcgttgtt taacatcggc ctccttcttt     5280

tcctggtcat gttcatctac gccatctttg ggatgtccaa ttttgcctat gttaagaggg     5340

aagttgggat cgatgacatg ttcaactttg agacctttgg caacagcatg atctgcctgt     5400

tccaaattac aacctctgct ggctgggatg gattgctagc acctattctt aatagtggac     5460

ctccagactg tgaccctgac aaagatcacc ctggaagctc agttaaagga gactgtggga     5520

acccatctgt tgggattttc ttttttgtca gttacatcat catatccttc ctggttgtgg     5580

tgaacatgta catcgcggtc atcctggaga acttcagtgt tgctactgaa gaaagtgcag     5640

agcctctgag tgaggatgac tttgagatgt tctatgaggt ttgggagaag tttgatcccg     5700

atgcgaccca gtttatagag tttgccaaac tttctgattt tgcagatgcc ctggatcctc     5760

ctcttctcat agcaaaaccc aacaaagtcc agctcattgc catggatctg cccatggtga     5820

gtggtgaccg gatccactgt cttgacatct tatttgcttt tacaaagcgt gttttgggtg     5880

agagtggaga gatggatgcc cttcgaatac agatggaaga gcgattcatg gcatcaaacc     5940

cctccaaagt ctcttatgag cccattacga ccacgttgaa acgcaaacaa gaggaggtgt     6000

ctgctattat tatccagagg gcttacagac gctacctctt gaagcaaaaa gttaaaaagg     6060

tatcaagtat atacaagaaa gacaaaggca aagaatgtga tggaacaccc atcaaagaag     6120

atactctcat tgataaactg aatgagaatt caactccaga gaaaaccgat atgacgcctt     6180

ccaccacgtc tccaccctcg tatgatagtg tgaccaaacc agaaaaagaa aaatttgaaa     6240

aagacaaatc agaaaaggaa gacaaaggga aagatatcag ggaaagtaaa aagtaaaaag     6300

aaaccaagaa ttttccattt tgtgatcaat tgtttacagc ccgtgatggt gatgtgtttg     6360

tgtcaacagg actcccacag gaggtctatg ccaaactgac tgtttttaca aatgtatact     6420

taaggtcagt gcctataaca agacagagac ctctggtcag caaactggaa ctcagtaaac     6480

tggagaaata gtatcgatgg gaggtttcta ttttcacaac cagctgacac tgctgaagag     6540

cagaggcgta atggctactc agacgatagg aaccaattta aaggggggag ggaagttaaa     6600

tttttatgta aattcaacat gtgacacttg ataatagtaa ttgtcaccag tgtttatgtt     6660

ttaactgcca cacctgccat atttttacaa aacgtgtgct gtgaatttat cacttttctt     6720

tttaattcac aggttgttta ctattatatg tgactatttt tgtaaatggg tttgtgtttg     6780

gggagaggga ttaaagggag ggaattctac atttctctat tgtattgtat aactggatat     6840

attttaaatg gaggcatgct gcaattctca ttcacacata aaaaaatcac atcacaaaag     6900

ggaagagttt acttcttgtt tcaggatgtt tttagatttt tgaggtgctt aaatagctat     6960

tcgtattttt aaggtgtctc atccagaaaa aatttaatgt gcctgtaaat gttccataga     7020

atcacaagca ttaaagagtt gttttatttt tacataaccc attaaatgta catgtatata     7080

tgtatatatg tatatgtgcg tgtatataca tatatatgta tacacacatg cacacacaga     7140

gatatacaca taccattaca ttgtcattca cagtcccagc agcatgacta tcacattttt     7200

gataagtgtc ctttggcata aaataaaaat atcctatcag tcctttctaa gaagcctgaa     7260

ttgaccaaaa aacatcccca ccaccacttt ataaagttga ttctgcttta tcctgcagta     7320

ttgtttagcc atcttctgct cttggtaagg ttgacatagt atatgtcaat ttaaaaaata     7380

aaagtctgct ttgtaaatag taattttacc cagtggtgca tgtttgagca aacaaaaatg     7440

atgatttaag cacactactt attgcatcaa atatgtacca cagtaagtat agtttgcaag     7500

ctttcaacag gtaatatgat gtaattggtt ccattatagt ttgaagctgt cactgctgca     7560

tgtttatctt gcctatgctg ctgtatctta ttccttccac tgttcagaag tctaatatgg     7620

gaagccatat atcagtggta aagtgaagca aattgttcta ccaagacctc attcttcatg     7680

tcattaagca ataggttgca gcaaacaagg aagagcttct tgctttttat tcttccaacc     7740

ttaattgaac actcaatgat gaaaagcccg actgtacaaa catgttgcaa gctgcttaaa     7800

tctgtttaaa atatatggtt agagttttct aagaaaatat aaatactgta aaaagttcat     7860

tttattttat ttttcagcct tttgtacgta aaatgagaaa ttaaaagtat cttcaggtgg     7920

atgtcacagt cactattgtt agtttctgtt cctagcactt ttaaattgaa gcacttcaca     7980

aaataagaag caaggactag gatgcagtgt aggtttctgc ttttttatta gtactgtaaa     8040

cttgcacaca tttcaatgtg aaacaaatct caaactgagt tcaatgttta tttgctttca     8100

atagtaatgc cttatcattg aaagaggctt aaagaaaaaa aaaatcagct gatactcttg     8160

gcattgcttg aatccaatgt ttccacctag tctttttatt cagtaatcat cagtcttttc     8220

caatgtttgt ttacacagat agatcttatt gacccatatg gcactagaac tgtatcagat     8280

ataatatggg atcccagctt tttttcctct cccacaaaac caggtagtga agttatatta     8340

ccagttacag caaaatactt tgtgtttcac aagcaacaat aaatgtagat tctttatact     8400

gaagctattg acttgtagtg tgttggtgaa atgcatgcag gaaaatgctg ttaccataaa     8460

gaacggtaaa ccacattaca atcaagccaa aagaataaag gtttcgcttt tgtttttgta     8520

tttaattgtt gtctttgttt ctatctttga aatgccattt aaaggtagat ttctatcatg     8580

taaaaataat ctatctgaaa aacaaatgta aagaacacac attaattact ataattcatc     8640

tttcaatttt ttcatggaat ggaagttaat taagaagagt gtattggata actactttaa     8700

tattggccaa aaagctagat atggcatcag gtagactagt ggaaagttac aaaaattaat     8760

aaaaaattga ctaaca                                                     8776


<210>  3
<211>  2005
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210>  4
<211>  8895
<212>  DNA
<213>  Homo Sapiens

<400>  4
aacagacatt gggtaccatc gaatgactgt cagaacagaa agctaaggca aaggagggag       60

gatgctgtgg tcatcctttc ttgttttttt cttctttaat gaggatagag cacatgtgag      120

attttacttt ctactccagt aaaaattctg aagaattgca ttggagactg ttatattcaa      180

cacatacgtg gattctgtgt tatgatttac atttttcttt atttcagggg tttttctccc      240

tttgcttgac acttctctgt cctgacacct tgagaagaag gatgtgtttg cttacccttc      300

cgccatgatt gtaaatttcc tgaggccttc ccagccatgc agcactcact ttcttatgca      360

aggagctaaa cagtgattaa aggagcagga tgaaaagatg gcacagtcag tgctggtacc      420

gccaggacct gacagcttcc gcttctttac cagggaatcc cttgctgcta ttgaacaacg      480

cattgcagaa gagaaagcta agagacccaa acaggaacgc aaggatgagg atgatgaaaa      540

tggcccaaag ccaaacagtg acttggaagc aggaaaatct cttccattta tttatggaga      600

cattcctcca gagatggtgt cagtgcccct ggaggatctg gacccctact atatcaataa      660

gaaaacgttt atagtattga ataaagggaa agcaatctct cgattcagtg ccacccctgc      720

cctttacatt ttaactccct tcaaccctat tagaaaatta gctattaaga ttttggtaca      780

ttctttattc aatatgctca ttatgtgcac gattcttacc aactgtgtat ttatgaccat      840

gagtaaccct ccagactgga caaagaatgt ggagtatacc tttacaggaa tttatacttt      900

tgaatcactt attaaaatac ttgcaagggg cttttgttta gaagatttca catttttacg      960

ggatccatgg aattggttgg atttcacagt cattactttt gcgtatgtaa cagaatttgt     1020

aaacctaggc aatgtttcag ctcttcgaac tttcagagtc ttgagagctt tgaaaactat     1080

ttctgtaatt ccaggcctga agaccattgt gggggccctg atccagtcag tgaagaagct     1140

ttctgatgtc atgatcttga ctgtgttctg tctaagcgtg tttgcgctaa taggattgca     1200

gttgttcatg ggcaacctac gaaataaatg tttgcaatgg cctccagata attcttcctt     1260

tgaaataaat atcacttcct tctttaacaa ttcattggat gggaatggta ctactttcaa     1320

taggacagtg agcatattta actgggatga atatattgag gataaaagtc acttttattt     1380

tttagagggg caaaatgatg ctctgctttg tggcaacagc tcagatgcag gccagtgtcc     1440

tgaaggatac atctgtgtga aggctggtag aaaccccaac tatggctaca cgagctttga     1500

cacctttagt tgggcctttt tgtccttatt tcgtctcatg actcaagact tctgggaaaa     1560

cctttatcaa ctgacactac gtgctgctgg gaaaacgtac atgatatttt ttgtgctggt     1620

cattttcttg ggctcattct atctaataaa tttgatcttg gctgtggtgg ccatggccta     1680

tgaggaacag aatcaggcca cattggaaga ggctgaacag aaggaagctg aatttcagca     1740

gatgctcgaa cagttgaaaa agcaacaaga agaagctcag gcggcagctg cagccgcatc     1800

tgctgaatca agagacttca gtggtgctgg tgggatagga gttttttcag agagttcttc     1860

agtagcatct aagttgagct ccaaaagtga aaaagagctg aaaaacagaa gaaagaaaaa     1920

gaaacagaaa gaacagtctg gagaagaaga gaaaaatgac agagtccgaa aatcggaatc     1980

tgaagacagc ataagaagaa aaggtttccg tttttccttg gaaggaagta ggctgacata     2040

tgaaaagaga ttttcttctc cacaccagtc cttactgagc atccgtggct cccttttctc     2100

tccaagacgc aacagtaggg cgagcctttt cagcttcaga ggtcgagcaa aggacattgg     2160

ctctgagaat gactttgctg atgatgagca cagcaccttt gaggacaatg acagccgaag     2220

agactctctg ttcgtgccgc acagacatgg agaacggcgc cacagcaatg tcagccaggc     2280

cagccgtgcc tccagggtgc tccccatcct gcccatgaat gggaagatgc atagcgctgt     2340

ggactgcaat ggtgtggtct ccctggtcgg gggcccttct accctcacat ctgctgggca     2400

gctcctacca gagggcacaa ctactgaaac agaaataaga aagagacggt ccagttctta     2460

tcatgtttcc atggatttat tggaagatcc tacatcaagg caaagagcaa tgagtatagc     2520

cagtattttg accaacacca tggaagaact tgaagaatcc agacagaaat gcccaccatg     2580

ctggtataaa tttgctaata tgtgtttgat ttgggactgt tgtaaaccat ggttaaaggt     2640

gaaacacctt gtcaacctgg ttgtaatgga cccatttgtt gacctggcca tcaccatctg     2700

cattgtctta aatacactct tcatggctat ggagcactat cccatgacgg agcagttcag     2760

cagtgtactg tctgttggaa acctggtctt cacagggatc ttcacagcag aaatgtttct     2820

caagataatt gccatggatc catattatta ctttcaagaa ggctggaata tttttgatgg     2880

ttttattgtg agccttagtt taatggaact tggtttggca aatgtggaag gattgtcagt     2940

tctccgatca ttccggctgc tccgagtttt caagttggca aaatcttggc caactctaaa     3000

tatgctaatt aagatcattg gcaattctgt gggggctcta ggaaacctca ccttggtatt     3060

ggccatcatc gtcttcattt ttgctgtggt cggcatgcag ctctttggta agagctacaa     3120

agaatgtgtc tgcaagattt ccaatgattg tgaactccca cgctggcaca tgcatgactt     3180

tttccactcc ttcctgatcg tgttccgcgt gctgtgtgga gagtggatag agaccatgtg     3240

ggactgtatg gaggtcgctg gccaaaccat gtgccttact gtcttcatga tggtcatggt     3300

gattggaaat ctagtggttc tgaacctctt cttggccttg cttttgagtt ccttcagttc     3360

tgacaatctt gctgccactg atgatgataa cgaaatgaat aatctccaga ttgctgtggg     3420

aaggatgcag aaaggaatcg attttgttaa aagaaaaata cgtgaattta ttcagaaagc     3480

ctttgttagg aagcagaaag ctttagatga aattaaaccg cttgaagatc taaataataa     3540

aaaagacagc tgtatttcca accataccac catagaaata ggcaaagacc tcaattatct     3600

caaagacgga aatggaacta ctagtggcat aggcagcagt gtagaaaaat atgtcgtgga     3660

tgaaagtgat tacatgtcat ttataaacaa ccctagcctc actgtgacag taccaattgc     3720

tgttggagaa tctgactttg aaaatttaaa tactgaagaa ttcagcagcg agtcagatat     3780

ggaggaaagc aaagagaagc taaatgcaac tagttcatct gaaggcagca cggttgatat     3840

tggagctccc gccgagggag aacagcctga ggttgaacct gaggaatccc ttgaacctga     3900

agcctgtttt acagaagact gtgtacggaa gttcaagtgt tgtcagataa gcatagaaga     3960

aggcaaaggg aaactctggt ggaatttgag gaaaacatgc tataagatag tggagcacaa     4020

ttggttcgaa accttcattg tcttcatgat tctgctgagc agtggggctc tggcctttga     4080

agatatatac attgagcagc gaaaaaccat taagaccatg ttagaatatg ctgacaaggt     4140

tttcacttac atattcattc tggaaatgct gctaaagtgg gttgcatatg gttttcaagt     4200

gtattttacc aatgcctggt gctggctaga cttcctgatt gttgatgtct cactggttag     4260

cttaactgca aatgccttgg gttactcaga acttggtgcc atcaaatccc tcagaacact     4320

aagagctctg aggccactga gagctttgtc ccggtttgaa ggaatgaggg ttgttgtaaa     4380

tgctctttta ggagccattc catctatcat gaatgtactt ctggtttgtc tgatcttttg     4440

gctaatattc agtatcatgg gagtgaatct ctttgctggc aagttttacc attgtattaa     4500

ttacaccact ggagagatgt ttgatgtaag cgtggtcaac aactacagtg agtgcaaagc     4560

tctcattgag agcaatcaaa ctgccaggtg gaaaaatgtg aaagtaaact ttgataacgt     4620

aggacttgga tatctgtctc tacttcaagt agccacgttt aagggatgga tggatattat     4680

gtatgcagct gttgattcac gaaatgtaga attacaaccc aagtatgaag acaacctgta     4740

catgtatctt tattttgtca tctttattat ttttggttca ttctttacct tgaatctttt     4800

cattggtgtc atcatagata acttcaacca acagaaaaag aagtttggag gtcaagacat     4860

ttttatgaca gaagaacaga agaaatacta caatgcaatg aaaaaactgg gttcaaagaa     4920

accacaaaaa cccatacctc gacctgctaa caaattccaa ggaatggtct ttgattttgt     4980

aaccaaacaa gtctttgata tcagcatcat gatcctcatc tgccttaaca tggtcaccat     5040

gatggtggaa accgatgacc agagtcaaga aatgacaaac attctgtact ggattaatct     5100

ggtgtttatt gttctgttca ctggagaatg tgtgctgaaa ctgatctctc ttcgttacta     5160

ctatttcact attggatgga atatttttga ttttgtggtg gtcattctct ccattgtagg     5220

aatgtttctg gctgaactga tagaaaagta ttttgtgtcc cctaccctgt tccgagtgat     5280

ccgtcttgcc aggattggcc gaatcctacg tctgatcaaa ggagcaaagg ggatccgcac     5340

gctgctcttt gctttgatga tgtcccttcc tgcgttgttt aacatcggcc tccttctttt     5400

cctggtcatg ttcatctacg ccatctttgg gatgtccaat tttgcctatg ttaagaggga     5460

agttgggatc gatgacatgt tcaactttga gacctttggc aacagcatga tctgcctgtt     5520

ccaaattaca acctctgctg gctgggatgg attgctagca cctattctta atagtggacc     5580

tccagactgt gaccctgaca aagatcaccc tggaagctca gttaaaggag actgtgggaa     5640

cccatctgtt gggattttct tttttgtcag ttacatcatc atatccttcc tggttgtggt     5700

gaacatgtac atcgcggtca tcctggagaa cttcagtgtt gctactgaag aaagtgcaga     5760

gcctctgagt gaggatgact ttgagatgtt ctatgaggtt tgggagaagt ttgatcccga     5820

tgcgacccag tttatagagt ttgccaaact ttctgatttt gcagatgccc tggatcctcc     5880

tcttctcata gcaaaaccca acaaagtcca gctcattgcc atggatctgc ccatggtgag     5940

tggtgaccgg atccactgtc ttgacatctt atttgctttt acaaagcgtg ttttgggtga     6000

gagtggagag atggatgccc ttcgaataca gatggaagag cgattcatgg catcaaaccc     6060

ctccaaagtc tcttatgagc ccattacgac cacgttgaaa cgcaaacaag aggaggtgtc     6120

tgctattatt atccagaggg cttacagacg ctacctcttg aagcaaaaag ttaaaaaggt     6180

atcaagtata tacaagaaag acaaaggcaa agaatgtgat ggaacaccca tcaaagaaga     6240

tactctcatt gataaactga atgagaattc aactccagag aaaaccgata tgacgccttc     6300

caccacgtct ccaccctcgt atgatagtgt gaccaaacca gaaaaagaaa aatttgaaaa     6360

agacaaatca gaaaaggaag acaaagggaa agatatcagg gaaagtaaaa agtaaaaaga     6420

aaccaagaat tttccatttt gtgatcaatt gtttacagcc cgtgatggtg atgtgtttgt     6480

gtcaacagga ctcccacagg aggtctatgc caaactgact gtttttacaa atgtatactt     6540

aaggtcagtg cctataacaa gacagagacc tctggtcagc aaactggaac tcagtaaact     6600

ggagaaatag tatcgatggg aggtttctat tttcacaacc agctgacact gctgaagagc     6660

agaggcgtaa tggctactca gacgatagga accaatttaa aggggggagg gaagttaaat     6720

ttttatgtaa attcaacatg tgacacttga taatagtaat tgtcaccagt gtttatgttt     6780

taactgccac acctgccata tttttacaaa acgtgtgctg tgaatttatc acttttcttt     6840

ttaattcaca ggttgtttac tattatatgt gactattttt gtaaatgggt ttgtgtttgg     6900

ggagagggat taaagggagg gaattctaca tttctctatt gtattgtata actggatata     6960

ttttaaatgg aggcatgctg caattctcat tcacacataa aaaaatcaca tcacaaaagg     7020

gaagagttta cttcttgttt caggatgttt ttagattttt gaggtgctta aatagctatt     7080

cgtattttta aggtgtctca tccagaaaaa atttaatgtg cctgtaaatg ttccatagaa     7140

tcacaagcat taaagagttg ttttattttt acataaccca ttaaatgtac atgtatatat     7200

gtatatatgt atatgtgcgt gtatatacat atatatgtat acacacatgc acacacagag     7260

atatacacat accattacat tgtcattcac agtcccagca gcatgactat cacatttttg     7320

ataagtgtcc tttggcataa aataaaaata tcctatcagt cctttctaag aagcctgaat     7380

tgaccaaaaa acatccccac caccacttta taaagttgat tctgctttat cctgcagtat     7440

tgtttagcca tcttctgctc ttggtaaggt tgacatagta tatgtcaatt taaaaaataa     7500

aagtctgctt tgtaaatagt aattttaccc agtggtgcat gtttgagcaa acaaaaatga     7560

tgatttaagc acactactta ttgcatcaaa tatgtaccac agtaagtata gtttgcaagc     7620

tttcaacagg taatatgatg taattggttc cattatagtt tgaagctgtc actgctgcat     7680

gtttatcttg cctatgctgc tgtatcttat tccttccact gttcagaagt ctaatatggg     7740

aagccatata tcagtggtaa agtgaagcaa attgttctac caagacctca ttcttcatgt     7800

cattaagcaa taggttgcag caaacaagga agagcttctt gctttttatt cttccaacct     7860

taattgaaca ctcaatgatg aaaagcccga ctgtacaaac atgttgcaag ctgcttaaat     7920

ctgtttaaaa tatatggtta gagttttcta agaaaatata aatactgtaa aaagttcatt     7980

ttattttatt tttcagcctt ttgtacgtaa aatgagaaat taaaagtatc ttcaggtgga     8040

tgtcacagtc actattgtta gtttctgttc ctagcacttt taaattgaag cacttcacaa     8100

aataagaagc aaggactagg atgcagtgta ggtttctgct tttttattag tactgtaaac     8160

ttgcacacat ttcaatgtga aacaaatctc aaactgagtt caatgtttat ttgctttcaa     8220

tagtaatgcc ttatcattga aagaggctta aagaaaaaaa aaatcagctg atactcttgg     8280

cattgcttga atccaatgtt tccacctagt ctttttattc agtaatcatc agtcttttcc     8340

aatgtttgtt tacacagata gatcttattg acccatatgg cactagaact gtatcagata     8400

taatatggga tcccagcttt ttttcctctc ccacaaaacc aggtagtgaa gttatattac     8460

cagttacagc aaaatacttt gtgtttcaca agcaacaata aatgtagatt ctttatactg     8520

aagctattga cttgtagtgt gttggtgaaa tgcatgcagg aaaatgctgt taccataaag     8580

aacggtaaac cacattacaa tcaagccaaa agaataaagg tttcgctttt gtttttgtat     8640

ttaattgttg tctttgtttc tatctttgaa atgccattta aaggtagatt tctatcatgt     8700

aaaaataatc tatctgaaaa acaaatgtaa agaacacaca ttaattacta taattcatct     8760

ttcaattttt tcatggaatg gaagttaatt aagaagagtg tattggataa ctactttaat     8820

attggccaaa aagctagata tggcatcagg tagactagtg gaaagttaca aaaattaata     8880

aaaaattgac taaca                                                      8895


