
                                SEQUENCE LISTING

<110> Vir Biotechnology, Inc.
      Pang, Phillip S.
      Mogalian, Erik
      Connolly, Lynne E.
      Gall, Jonathan

<120> COMPOSITIONS AND METHODS FOR TREATING HEPATITS B
      VIRUS INFECTION

<130> 930485.412WO

<140> PCT
<141> 2020-08-28

<150> US 62/893,742
<151> 2019-08-29

<160> 139

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 11
<212> PRT
<213> Hepatitus B virus

<220> 
<221> VARIANT        
<222> (1)...(11)
<223> Xaa = any amino acid

<400> 1
Xaa Xaa Xaa Thr Cys Xaa Xaa Xaa Ala Xaa Gly
 1               5                  10

<210> 2
<211> 11
<212> PRT
<213> Hepatitus B Virus

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = P, T or S,

<220>
<221> VARIANT        
<222> 2
<223> Xaa = C or S,

<220>
<221> VARIANT        
<222> 3
<223> Xaa = R, K, D or I,

<220>
<221> VARIANT        
<222> 6
<223> Xaa = M or T

<220>
<221> VARIANT        
<222> 7
<223> Xaa = T, A or I

<220>
<221> VARIANT        
<222> 8
<223> Xaa = T, P or L

<220>
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = Q, H or L.

<400> 2
Xaa Xaa Xaa Thr Cys Xaa Xaa Xaa Ala Xaa Gly
 1               5                  10

<210> 3
<211> 226
<212> PRT
<213> Hepatitis B Virus

<220>      
<223> S domain of HBsAg (GenBank acc. no. J02203)

<400> 3
Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln
 1               5                  10                  15
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu
            20                  25                  30
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys
        35                  40                  45
Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser
    50                  55                  60
Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe
65                  70                  75                  80
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val
                85                  90                  95
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly
            100                 105                 110
Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Met Thr Thr Ala
        115                 120                 125
Gln Gly Thr Ser Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp
    130                 135                 140
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys
145                 150                 155                 160
Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu
                165                 170                 175
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu
            180                 185                 190
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile
        195                 200                 205
Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val
    210                 215                 220
Tyr Ile
225

<210> 4
<211> 226
<212> PRT
<213> Hepatits B Virus

<220> 
<223> S domain of HBsAg (GenBank acc. no. FJ899792)

<400> 4
Met Glu Asn Val Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln
 1               5                  10                  15
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu
            20                  25                  30
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys
        35                  40                  45
Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser
    50                  55                  60
Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe
65                  70                  75                  80
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val
                85                  90                  95
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly
            100                 105                 110
Ser Ser Thr Thr Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala
        115                 120                 125
Gln Gly Thr Ser Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp
    130                 135                 140
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys
145                 150                 155                 160
Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu
                165                 170                 175
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu
            180                 185                 190
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Thr
        195                 200                 205
Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val
    210                 215                 220
Tyr Ile
225

<210> 5
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> J02203 (D, ayw3)

<400> 5
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Arg Thr Cys Met Thr Thr Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 6
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> FJ899792 (D, adw2)

<400> 6
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 7
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AM282986 (A)

<400> 7
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Thr Thr Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu
    50                  55                  60
Trp Ala Ser Val Arg Phe Ser Trp
65                  70

<210> 8
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> D23678 (B1)

<400> 8
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu
    50                  55                  60
Trp Ala Ser Val Arg Phe Ser Trp
65                  70

<210> 9
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AB117758 (C1)

<400> 9
Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Thr Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Ile Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Val Arg Phe Ser Trp
65                  70

<210> 10
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AB205192 (E)

<400> 10
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Arg Thr Cys Thr Thr Leu Ala Gln Gly Thr Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Ser Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 11
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> X69798 (F4)

<400> 11
Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Ser Thr Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Leu Ala Gln Gly Thr Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Ser Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Leu Gly Lys Tyr Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 12
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AF160501 (G)

<400> 12
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu
    50                  55                  60
Trp Ala Ser Val Arg Phe Ser Trp
65                  70

<210> 13
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AY090454 (H)

<400> 13
Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Ser Thr Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Leu Ala Gln Gly Thr Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Tyr Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 14
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AF241409 (I)

<400> 14
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 15
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> AB486012 (J)

<400> 15
Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly Ser Thr Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Arg Thr Cys Thr Ile Thr Ala Gln Gly Thr Ser
            20                  25                  30
Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Val Arg Phe Ser Trp
65                  70

<210> 16
<211> 73
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg Y100C/P120T

<400> 16
Cys Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr
 1               5                  10                  15
Thr Gly Thr Gly Thr Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr
            20                  25                  30
Ser Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys
        35                  40                  45
Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp
    50                  55                  60
Glu Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 17
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg P120T

<400> 17
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Thr Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 18
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg P120T/S143L

<400> 18
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Thr Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Leu Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 19
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg C121S

<400> 19
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Ser Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 20
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg R122D

<400> 20
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Asp Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 21
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg R122I

<400> 21
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Ile Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 22
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg T123N

<400> 22
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Asn Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 23
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg Q129H

<400> 23
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala His Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 24
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg Q129L

<400> 24
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Leu Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 25
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg M133H

<400> 25
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
His Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 26
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg M133L

<400> 26
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Leu Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 27
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg M133T

<400> 27
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Thr Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 28
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg K141E

<400> 28
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Glu Pro Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 29
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg P142S

<400> 29
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Ser Ser Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 30
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg S143K

<400> 30
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Lys Asp Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 31
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg D144A

<400> 31
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Ala Gly Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 32
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg G145R

<400> 32
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Arg Asn Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 33
<211> 72
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> HBsAg N146A

<400> 33
Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr
 1               5                  10                  15
Gly Thr Gly Pro Cys Arg Thr Cys Thr Thr Pro Ala Gln Gly Thr Ser
            20                  25                  30
Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp Gly Ala Cys Thr
        35                  40                  45
Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys Phe Leu Trp Glu
    50                  55                  60
Trp Ala Ser Ala Arg Phe Ser Trp
65                  70

<210> 34
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRH1

<400> 34
Gly Arg Ile Phe Arg Ser Phe Tyr
 1               5

<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRH2

<400> 35
Asn Gln Asp Gly Ser Glu Lys
 1               5

<210> 36
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRH3

<400> 36
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val
 1               5                  10

<210> 37
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL1

<400> 37
Lys Leu Gly Asn Lys Asn
 1               5

<210> 38
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL2

<400> 38
Glu Val Lys
 1

<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL2 long

<400> 39
Val Ile Tyr Glu Val Lys Tyr Arg Pro
 1               5

<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL3

<400> 40
Gln Thr Trp Asp Ser Thr Thr Val Val
 1               5

<210> 41
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34, HBC34-V7, HBC34-V34,
      HBC34-V35 VH

<400> 41
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser
        115

<210> 42
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 VL

<400> 42
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Cys Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Trp Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 43
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRH1

<400> 43
ggacgcatct ttagaagttt ttac                                             24

<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRH2

<400> 44
ataaaccaag atggaagtga gaaa                                             24

<210> 45
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRH3

<400> 45
gcggcttgga gcggcaatag tgggggtatg gacgtc                                36

<210> 46
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL1

<400> 46
aaattgggga ataaaaat                                                    18

<210> 47
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL2

<400> 47
gaggttaaa                                                               9

<210> 48
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL2 long

<400> 48
gtcatctatg aggttaaata ccgcccc                                          27

<210> 49
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 CDRL3

<400> 49
cagacgtggg acagcaccac tgtggtg                                          27

<210> 50
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 VH

<400> 50
gaactgcagc tggtggagtc tgggggaggc tgggtccagc cgggggggtc ccagagactg      60
tcctgtgcag cctctggacg catctttaga agtttttaca tgagctgggt ccgccaggcc     120
ccagggaagg ggctggagtg ggtggccact ataaaccaag atggaagtga gaaattatat     180
gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactattt     240
ctgcaaatga acaacctgag agtcgaggac acggccgttt attactgcgc ggcttggagc     300
ggcaatagtg ggggtatgga cgtctggggc caggggacca cggtctccgt ctcctca        357

<210> 51
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 VL

<400> 51
tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agtcagcatc      60
ccctgctctg gagataaatt ggggaataaa aatgtttgct ggtttcagca taagccaggc     120
cagtcccctg tgttggtcat ctatgaggtt aaataccgcc cctcggggat tcctgagcga     180
ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg     240
gatgaggctg cctatttctg tcagacgtgg gacagcacca ctgtggtgtt cggcggaggg     300
accaggctga ccgtccta                                                   318

<210> 52
<211> 33
<212> PRT
<213> Hepatitis B Virus

<220> 
<221> VARIANT        
<222> (1)...(33)
<223> Xaa = Any Amino Acid

<400> 52
Xaa Gly Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Met Thr
 1               5                  10                  15
Xaa Pro Ser Asp Gly Asn Ala Thr Ala Ile Pro Ile Pro Ser Ser Trp
            20                  25                  30
Xaa


<210> 53
<211> 15
<212> PRT
<213> Hepatitis B Virus

<400> 53
Thr Ser Thr Gly Pro Cys Arg Thr Cys Met Thr Thr Ala Gln Gly
 1               5                  10                  15

<210> 54
<211> 26
<212> PRT
<213> Hepatitis B Virus

<400> 54
Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Ser Thr Thr Ser
 1               5                  10                  15
Thr Gly Pro Cys Arg Thr Cys Met Thr Thr
            20                  25

<210> 55
<211> 33
<212> PRT
<213> Hepatitis B Virus

<220> 
<221> VARIANT        
<222> (1)...(33)
<223> Xaa = Any Amino Acid

<400> 55
Xaa Ser Met Tyr Pro Ser Ala Ser Ala Thr Lys Pro Ser Asp Gly Asn
 1               5                  10                  15
Xaa Thr Gly Pro Cys Arg Thr Cys Met Thr Thr Ala Gln Gly Thr Ser
            20                  25                  30
Xaa


<210> 56
<211> 11
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> amino acids 120 - 130 of the S domain of HBsAg
      (HBV-D J02203)

<400> 56
Pro Cys Arg Thr Cys Met Thr Thr Ala Gln Gly
 1               5                  10

<210> 57
<211> 11
<212> PRT
<213> Hepatitis B Virus

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = R or K

<220>
<221> VARIANT        
<222> 6
<223> Xaa = M or T

<220>
<221> VARIANT        
<222> 7
<223> Xaa = T or I

<220>
<221> VARIANT        
<222> 8
<223> Xaa = T, P or L

<400> 57
Pro Cys Xaa Thr Cys Xaa Xaa Xaa Ala Gln Gly
 1               5                  10

<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 CDRL3 and HBC34-V23
      CDRL3

<400> 58
Gln Thr Phe Asp Ser Thr Thr Val Val
 1               5

<210> 59
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 VL

<400> 59
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Cys Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 60
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v7 CDRL1 and HBC-V23 CDRL1

<400> 60
aagctgggga acaaaaat                                                    18

<210> 61
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 CDRL2 and HBC34v23
      CDRL2

<400> 61
gaggtgaaa                                                               9

<210> 62
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 CDRL2 long and CDRL2
      HBC34-V23 long

<400> 62
gtcatctacg aggtgaaata tcggcct                                          27

<210> 63
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRL3 HBC34-V7 and CDRL3
      HBC34-V23

<400> 63
cagacattcg attccaccac agtggtc                                          27

<210> 64
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7, HBC34-V34, and
      HBC34-V35 VL

<400> 64
tcttacgagc tgacacagcc acctagcgtg tccgtctctc caggacagac cgtgtccatc      60
ccttgctctg gcgacaagct ggggaacaaa aatgtctgtt ggttccagca caagccaggg     120
cagagtcccg tgctggtcat ctacgaggtg aaatatcggc cttcaggaat tccagaacgg     180
ttcagcggat caaacagcgg caatactgca accctgacaa ttagcgggac ccaggccatg     240
gacgaagccg cttatttctg ccagacattc gattccacca cagtggtctt tggcggggga     300
actaggctga ccgtgctg                                                   318

<210> 65
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V23 VL

<400> 65
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Ala
            20                  25                  30
Cys Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105

<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34wt CDRH2

<400> 66
Ile Asn Gln Asp Gly Ser Glu Lys
 1               5

<210> 67
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V31, HBC34-V32 and
      HBC34-V33 VH

<400> 67
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Thr Val Ser Ser
        115

<210> 68
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V31, HBC34-V32 and
      HBC34-V33 VH

<400> 68
gaggtgcagc tggtggaatc cggcggggga ctggtgcagc ctggcggctc actgagactg      60
agctgtgcag cttctggaag aatcttcaga tctttttaca tgagttgggt gagacaggct     120
cctgggaagg gactggagtg ggtcgcaaac atcaatcagg acggatcaga aaagctgtat     180
gtggatagcg tcaaaggcag gttcactatt tcccgcgaca acgccaaaaa ttctctgttt     240
ctgcagatga acaatctgcg ggtggaggat accgctgtct actattgtgc agcctggtct     300
ggcaacagtg gaggcatgga cgtgtgggga cagggaacca cagtgacagt cagctcc        357

<210> 69
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v23 VL

<400> 69
tcttacgagc tgacacagcc ccctagcgtg tccgtctctc caggccagac agcatccatc      60
acttgctctg gcgacaagct ggggaacaaa aatgcctgtt ggtatcagca gaagccaggg     120
cagagtcccg tgctggtcat ctacgaggtg aaatatcggc cttcaggaat tccagaaaga     180
ttcagtggat caaacagcgg caatactgct accctgacaa ttagcgggac ccaggccatg     240
gacgaagctg attactattg ccagacattc gattccacca cagtggtctt tggcggggga     300
actaagctga ccgtgctg                                                   318

<210> 70
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt VH codon optimized
      

<400> 70
gaactgcagc tggtcgaatc aggaggaggg tgggtccagc ccggagggag ccagagactg      60
tcttgtgccg catcagggag gatcttcagg agcttctaca tgtcctgggt gcgccaggca     120
ccaggcaagg gactggagtg ggtcgccacc atcaaccagg acggatctga aaagctgtat     180
gtggatagtg tcaaaggccg gttcacaatt agcagagaca acgctaaaaa ttctctgttt     240
ctgcagatga acaatctgcg agtggaggat accgccgtct actattgcgc cgcttggtct     300
ggcaacagcg gcgggatgga tgtctggggg cagggcacaa cagtgagcgt ctcttcc        357

<210> 71
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt VL codon optimized
      

<400> 71
tcatacgaac tgactcagcc tccctccgtc tccgtctcac ctggacagac cgtctcaatc      60
ccctgctccg gcgataaact gggcaacaag aacgtgtgct ggttccagca caaacccgga     120
cagagtcctg tgctggtcat ctacgaggtc aagtatcggc caagcggcat tcccgaaaga     180
ttcagcggct ccaactctgg gaataccgca acactgacta tctctggaac ccaggcaatg     240
gacgaggcag cttacttttg ccagacttgg gattcaacta ctgtcgtgtt cggcggcgga     300
actagactga ctgtcctg                                                   318

<210> 72
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRH1 codon optimized
      

<400> 72
gggaggatct tcaggagctt ctac                                             24

<210> 73
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRH2 codon optimized
      

<400> 73
atcaaccagg acggatctga aaag                                             24

<210> 74
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRH3 codon optimized
      

<400> 74
gccgcttggt ctggcaacag cggcgggatg gatgtc                                36

<210> 75
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRL1 codon optimized
      

<400> 75
aaactgggca acaagaac                                                    18

<210> 76
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRL2 codon optimized
      

<400> 76
gaggtcaag                                                               9

<210> 77
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRL2 long codon
      optimized
      

<400> 77
gtcatctacg aggtcaagta tcggcca                                          27

<210> 78
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34 wt CDRL3 codon optimized
      

<400> 78
cagacttggg attcaactac tgtcgtg                                          27

<210> 79
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic linker sequence
      

<400> 79
Gly Gly Ser Gly Gly
 1               5

<210> 80
<211> 7
<212> PRT
<213> Hepatitis B Virus

<400> 80
Thr Gly Pro Cys Arg Thr Cys
 1               5

<210> 81
<211> 7
<212> PRT
<213> Hepatitis B Virus

<400> 81
Gly Asn Cys Thr Cys Ile Pro
 1               5

<210> 82
<211> 25
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> discontinuous  epitope mimic

<221> VARIANT        
<222> 2, 21, 24
<223> Cysteine coupled to acetamidomethyl

<400> 82
Cys Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Cys Ser Thr Thr
 1               5                  10                  15
Ser Thr Gly Pro Cys Arg Thr Cys Cys
            20                  25

<210> 83
<211> 28
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> discontinuous epitope mimic

<221> VARIANT        
<222> 4,6, 24, 27
<223> Cys is coupled to acetamidomethyl

<400> 83
Cys Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Cys
 1               5                  10                  15
Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Cys
            20                  25

<210> 84
<211> 17
<212> PRT
<213> Hepatitis B Virus

<220> 
<223> looped epitope mimic

<221> VARIANT        
<222> 13, 16
<223> cys is coupled to acetamidomethyl

<400> 84
Cys Gly Gly Gly Cys Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys
 1               5                  10                  15
Cys


<210> 85
<211> 11
<212> PRT
<213> Hepatitis B virus

<400> 85
Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys
 1               5                  10

<210> 86
<211> 15
<212> PRT
<213> Hepatitis B Virus

<400> 86
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Cys
 1               5                  10                  15

<210> 87
<211> 14
<212> PRT
<213> Hepatitis B Virus

<400> 87
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe
 1               5                  10

<210> 88
<211> 5
<212> PRT
<213> Hepatitis B Virus

<220> 
<221> VARIANT        
<222> (1)...(5)
<223> Xaa = Any Amino Acid

<400> 88
Pro Cys Arg Xaa Cys
 1               5

<210> 89
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V35 VL
      

<400> 89
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 90
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V34 VL
      

<400> 90
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ser Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 91
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HC of HBC34-V35-MLNS-GAALIE and
      HBC34-V34-MLNS-GAALIE (g1M17, 1)
      

<400> 91
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro
225                 230                 235                 240
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu Lys
                325                 330                 335
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu
            420                 425                 430
Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445
Lys


<210> 92
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HC of HBC34-V35-MLNS and
      HBC34-V34-MLNS (g1M17, 1)
      

<400> 92
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu
            420                 425                 430
Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445
Lys


<210> 93
<211> 212
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence LC of HBC34-V35

<400> 93
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln Pro Lys Ala Ala
            100                 105                 110
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
        115                 120                 125
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
    130                 135                 140
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
145                 150                 155                 160
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
                165                 170                 175
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
            180                 185                 190
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
        195                 200                 205
Thr Glu Cys Ser
    210

<210> 94
<211> 212
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence LC of HBC34-V34

<400> 94
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ser Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln Pro Lys Ala Ala
            100                 105                 110
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn
        115                 120                 125
Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val
    130                 135                 140
Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu
145                 150                 155                 160
Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser
                165                 170                 175
Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser
            180                 185                 190
Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro
        195                 200                 205
Thr Glu Cys Ser
    210

<210> 95
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24 VH

<400> 95
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Thr Lys Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Ser Ile Ser Gly Ser Val Pro Gly Phe Gly Ile Asp Thr Tyr Tyr
    50                  55                  60
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys
65                  70                  75                  80
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95
Leu Tyr Tyr Cys Ala Lys Asp Val Gly Val Ile Gly Ser Tyr Tyr Tyr
            100                 105                 110
Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
        115                 120                 125

<210> 96
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24 VL

<400> 96
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Leu Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Ser Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Tyr Ser Pro
                85                  90                  95
Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 97
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRH1 of HBC24

<400> 97
Gly Ser Thr Phe Thr Lys Tyr Ala
 1               5

<210> 98
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRH2 of HBC24

<400> 98
Ile Ser Gly Ser Val Pro Gly Phe
 1               5

<210> 99
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRH3 of HBC24

<400> 99
Leu Tyr Tyr Cys Ala Lys Asp Val Gly Val Ile Gly Ser Tyr Tyr Tyr
 1               5                  10                  15
Tyr Ala Met Asp Val
            20

<210> 100
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRL1 of HBC24

<400> 100
Gln Gly Leu Ser Ser Ser Tyr
 1               5

<210> 101
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRL2 of HBC24

<400> 101
Ser Ala Ser
 1

<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDRL3 of HBC24

<400> 102
Gln Gln Tyr Ala Tyr Ser Pro Arg Trp Thr
 1               5                  10

<210> 103
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH of  HBC34-V7, HBC34-V35, and
      HBC34-V34 (codon optimized)

<400> 103
gagctgcagc tggtggagtc cggcggcggc tgggtgcagc ctggcggctc ccagaggctg      60
agctgtgccg cttctggcag gatcttccgg tccttttaca tgtcttgggt gcggcaggct     120
ccaggcaagg gcctggagtg ggtggctacc atcaaccagg acggctccga gaagctgtat     180
gtggatagcg tgaagggcag attcacaatc tctcgcgaca acgccaagaa ctccctgttt     240
ctgcagatga acaatctgag ggtggaggat accgccgtgt actattgcgc cgcttggtct     300
ggcaatagcg gcggcatgga cgtgtgggga cagggcacca ccgtgtccgt gtccagc        357

<210> 104
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V34 VL (codon optimized)
      

<400> 104
agctacgagc tgacacagcc cccttccgtg tccgtgtccc ctggacagac cgtgtccatc      60
ccatgcagcg gcgacaagct gggcaacaag aacgtgtcct ggtttcagca taagcctggc     120
cagtcccccg tgctggtcat ctacgaggtg aagtataggc ccagcggcat ccctgagcgg     180
ttctctggct ccaacagcgg caatacagcc accctgacaa tctctggcac acaggctatg     240
gacgaggccg cttatttctg ccagaccttt gattccacca cagtggtgtt cggcggcggc     300
accagactga cagtgctg                                                   318

<210> 105
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V35 VL (codon optimized)
      

<400> 105
agctacgagc tgacacagcc cccttccgtg tccgtgtccc ctggacagac cgtgtccatc      60
ccatgcagcg gcgacaagct gggcaacaag aacgtggcct ggtttcagca taagcctggc     120
cagtcccccg tgctggtcat ctacgaggtg aagtataggc ccagcggcat ccctgagcgg     180
ttctctggct ccaacagcgg caatacagcc accctgacaa tctctggcac acaggctatg     240
gacgaggccg cttatttctg ccagaccttt gattccacca cagtggtgtt cggcggcggc     300
accagactga cagtgctg                                                   318

<210> 106
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24 VH (wild type)
      

<400> 106
gaggtgcagt tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc      60
tcctgtgcag cctctggatc cacttttacc aaatatgcca tgagctgggt ccgtcaggct     120
ccagggaagg ggctggagtg ggtcgcaagt attagtggaa gtgttcctgg ttttggtatt     180
gacacatact acgcagactc cgttaagggc cggttcacca tctccagaga cacttccaag     240
aacaccctgt atctgcaaat gaacagcctg agagccgagg acacggcctt atattactgt     300
gcgaaagatg tcggggttat cgggtcatac tattactacg ctatggacgt ctggggtcaa     360

<210> 107
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24 VL (wild type)
      

<400> 107
aaattgtgtt gacgcagtct ccaggcaccc tgtctttgtc tccaggggaa agagccaccc      60
tctcctgcag ggccagtcag ggtcttagca gcagttactt agcctggtac cagcagaaac     120
ctggccaggc tcccaggctc ctcatctata gtgcgtccac cagggccact ggcatcccag     180
acaggttcag tggcagtggg tctgggacag acttcactct caccatcagc agactggagc     240
ctgaagattt tgcagtgtat tactgtcaac agtatgctta ctcacctcgg tggacgttcg     300
gccaagggac caaggtggag atcaaac                                         327

<210> 108
<211> 384
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24 VH (codon optimized)

<400> 108
gaggtgcagc tgctggaaag cggcggcggc ctggtgcagc ccggcggctc cctgaggctg      60
tcttgcgccg cctctggcag caccttcaca aagtatgcaa tgtcttgggt gcgccaggca     120
ccaggcaagg gcctggagtg ggtggcctcc atctctggca gcgtgcctgg cttcggcatc     180
gacacctact atgccgattc cgtgaagggc cggtttacaa tcagcagaga cacctccaag     240
aacacactgt atctgcagat gaattctctg cgggccgagg acaccgccct gtactattgt     300
gccaaggatg tgggcgtgat cggcagctac tattactatg caatggacgt gtggggacag     360
ggaacagcag tgacagtgag ctcc                                            384

<210> 109
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24 VL (codon optimized)

<400> 109
gagatcgtgc tgacccagtc tcctggcaca ctgtccctgt cccctggaga gagagccacc      60
ctgtcctgca gagcctctca gggcctgagc tcctcttacc tggcctggta tcagcagaag     120
cctggacagg cccctcggct gctgatctac tctgcctcca ccagagcaac aggcattcct     180
gaccgcttct ccggatctgg aagcggcaca gacttcaccc tgacaatcag ccggctggag     240
cctgaggact tcgccgtgta ctattgtcag cagtacgcct attccccaag gtggaccttt     300
ggccagggca caaaggtgga gatcaag                                         327

<210> 110
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 VL (codon optimized)

<400> 110
agctacgagc tgacacagcc cccttccgtg tccgtgtccc ctggacagac cgtgtccatc      60
ccatgcagcg gcgacaagct gggcaacaag aacgtgtgct ggtttcagca taagcctggc     120
cagtcccccg tgctggtcat ctacgaggtg aagtataggc ccagcggcat ccctgagcgg     180
ttctctggct ccaacagcgg caatacagcc accctgacaa tctctggcac acaggctatg     240
gacgaggccg cttatttctg ccagaccttt gattccacca cagtggtgtt cggcggcggc     300
accagactga cagtgctg                                                   318

<210> 111
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v23-L_C40S

<400> 111
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Ala
            20                  25                  30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105

<210> 112
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v23-L_C40A

<400> 112
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Ala
            20                  25                  30
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105

<210> 113
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v31-L_C40S

<400> 113
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ser Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Trp Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 114
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v31-L_C40A

<400> 114
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Trp Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 115
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v32-L_C40S

<400> 115
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ser Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 116
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v32-L_C40A

<400> 116
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Trp Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 117
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v33-L_C40S

<400> 117
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Ala
            20                  25                  30
Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105

<210> 118
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34v33-L_C40A

<400> 118
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Ala
            20                  25                  30
Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105

<210> 119
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-L_C40S

<400> 119
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ser Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Trp Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 120
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-L_C40A

<400> 120
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Trp Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu
            100                 105

<210> 121
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24-MLNS

<400> 121
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Thr Lys Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Ser Ile Ser Gly Ser Val Pro Gly Phe Gly Ile Asp Thr Tyr Tyr
    50                  55                  60
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys
65                  70                  75                  80
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95
Leu Tyr Tyr Cys Ala Lys Asp Val Gly Val Ile Gly Ser Tyr Tyr Tyr
            100                 105                 110
Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
        115                 120                 125
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
    130                 135                 140
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
145                 150                 155                 160
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                165                 170                 175
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
            180                 185                 190
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
        195                 200                 205
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
    210                 215                 220
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
225                 230                 235                 240
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                245                 250                 255
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            260                 265                 270
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        275                 280                 285
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    290                 295                 300
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
305                 310                 315                 320
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                325                 330                 335
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            340                 345                 350
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        355                 360                 365
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    370                 375                 380
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
385                 390                 395                 400
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                405                 410                 415
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            420                 425                 430
Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr
        435                 440                 445
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455

<210> 122
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24-MLNS-GAALIE

<400> 122
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Thr Lys Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Ser Ile Ser Gly Ser Val Pro Gly Phe Gly Ile Asp Thr Tyr Tyr
    50                  55                  60
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys
65                  70                  75                  80
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95
Leu Tyr Tyr Cys Ala Lys Asp Val Gly Val Ile Gly Ser Tyr Tyr Tyr
            100                 105                 110
Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
        115                 120                 125
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
    130                 135                 140
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
145                 150                 155                 160
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                165                 170                 175
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
            180                 185                 190
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
        195                 200                 205
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
    210                 215                 220
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
225                 230                 235                 240
Pro Ala Pro Glu Leu Leu Ala Gly Pro Ser Val Phe Leu Phe Pro Pro
                245                 250                 255
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            260                 265                 270
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
        275                 280                 285
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    290                 295                 300
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
305                 310                 315                 320
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                325                 330                 335
Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly
            340                 345                 350
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
        355                 360                 365
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    370                 375                 380
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
385                 390                 395                 400
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                405                 410                 415
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
            420                 425                 430
Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr
        435                 440                 445
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455

<210> 123
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7-mu (IgG2a) HC

<400> 123
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr
        115                 120                 125
Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu
    130                 135                 140
Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp
145                 150                 155                 160
Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175
Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser
            180                 185                 190
Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser
        195                 200                 205
Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys
    210                 215                 220
Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro
225                 230                 235                 240
Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser
                245                 250                 255
Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp
            260                 265                 270
Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr
        275                 280                 285
Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val
    290                 295                 300
Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu
305                 310                 315                 320
Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg
                325                 330                 335
Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val
            340                 345                 350
Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr
        355                 360                 365
Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr
    370                 375                 380
Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys
                405                 410                 415
Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu
            420                 425                 430
Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly
        435                 440                 445
Lys


<210> 124
<211> 212
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7-mu (IgG2a) LC

<400> 124
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Cys Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln Pro Lys Ser Ser
            100                 105                 110
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Glu Thr Asn
        115                 120                 125
Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro Gly Val Val
    130                 135                 140
Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln Gly Met Glu
145                 150                 155                 160
Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met Ala Ser Ser
                165                 170                 175
Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser Ser Tyr Ser
            180                 185                 190
Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu Ser Arg
        195                 200                 205
Ala Asp Cys Ser
    210

<210> 125
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V35-mu (IgG2a) HC

<400> 125
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr
        115                 120                 125
Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu
    130                 135                 140
Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp
145                 150                 155                 160
Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175
Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser
            180                 185                 190
Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser
        195                 200                 205
Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys
    210                 215                 220
Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro
225                 230                 235                 240
Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser
                245                 250                 255
Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp
            260                 265                 270
Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr
        275                 280                 285
Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val
    290                 295                 300
Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu
305                 310                 315                 320
Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg
                325                 330                 335
Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val
            340                 345                 350
Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr
        355                 360                 365
Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr
    370                 375                 380
Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys
                405                 410                 415
Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu
            420                 425                 430
Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly
        435                 440                 445
Lys


<210> 126
<211> 212
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V35-mu (IgG2a) LC

<400> 126
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Val Ser Ile Pro Cys Ser Gly Asp Lys Leu Gly Asn Lys Asn Val
            20                  25                  30
Ala Trp Phe Gln His Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45
Glu Val Lys Tyr Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80
Asp Glu Ala Ala Tyr Phe Cys Gln Thr Phe Asp Ser Thr Thr Val Val
                85                  90                  95
Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln Pro Lys Ser Ser
            100                 105                 110
Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Glu Thr Asn
        115                 120                 125
Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro Gly Val Val
    130                 135                 140
Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln Gly Met Glu
145                 150                 155                 160
Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met Ala Ser Ser
                165                 170                 175
Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser Ser Tyr Ser
            180                 185                 190
Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu Ser Arg
        195                 200                 205
Ala Asp Cys Ser
    210

<210> 127
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24-mu (IgG2a) HC

<400> 127
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Thr Lys Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Ser Ile Ser Gly Ser Val Pro Gly Phe Gly Ile Asp Thr Tyr Tyr
    50                  55                  60
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys
65                  70                  75                  80
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala
                85                  90                  95
Leu Tyr Tyr Cys Ala Lys Asp Val Gly Val Ile Gly Ser Tyr Tyr Tyr
            100                 105                 110
Tyr Ala Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser
        115                 120                 125
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly
    130                 135                 140
Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr
145                 150                 155                 160
Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser
                165                 170                 175
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu
            180                 185                 190
Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile
        195                 200                 205
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys
    210                 215                 220
Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys
225                 230                 235                 240
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro
                245                 250                 255
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys
            260                 265                 270
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp
        275                 280                 285
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg
    290                 295                 300
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln
305                 310                 315                 320
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn
                325                 330                 335
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly
            340                 345                 350
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu
        355                 360                 365
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met
    370                 375                 380
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu
385                 390                 395                 400
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe
                405                 410                 415
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn
            420                 425                 430
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr
        435                 440                 445
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
    450                 455

<210> 128
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC24-mu (IgG2a) LC

<400> 128
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Leu Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Ser Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Tyr Ser Pro
                85                  90                  95
Arg Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Asp Ala
            100                 105                 110
Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser
        115                 120                 125
Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp
    130                 135                 140
Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val
145                 150                 155                 160
Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met
                165                 170                 175
Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser
            180                 185                 190
Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys
        195                 200                 205
Ser Phe Asn Arg Asn Glu Cys
    210                 215

<210> 129
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7, HBC34-V34, HBC34-V35
      HC (wild-type)
      

<400> 129
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445
Lys


<210> 130
<211> 990
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7, HBC34-V34, HBC34-V35
      CH1-hinge-CH2-CH3 (codon-optimized)

<400> 130
gcctccacaa agggcccaag cgtgtttcca ctggctccct cttccaagtc tacctccggc      60
ggcacagccg ctctgggatg tctggtgaag gattacttcc cagagcccgt gaccgtgtct     120
tggaactccg gcgccctgac cagcggagtg catacatttc cagctgtgct gcagagctct     180
ggcctgtact ctctgtccag cgtggtgacc gtgccctctt ccagcctggg cacccagaca     240
tatatctgca acgtgaatca caagccaagc aatacaaagg tggacaagaa ggtggagccc     300
aagtcttgtg ataagaccca tacatgccct ccatgtccag ctccagagct gctgggcggc     360
ccaagcgtgt tcctgtttcc acccaagcct aaggataccc tgatgatctc cagaaccccc     420
gaggtgacat gcgtggtggt ggacgtgagc cacgaggatc ctgaggtgaa gttcaactgg     480
tacgtggacg gcgtggaggt gcataatgct aagaccaagc ccagggagga gcagtacaac     540
tctacctatc gggtggtgtc cgtgctgaca gtgctgcacc aggattggct gaacggcaag     600
gagtataagt gcaaggtgtc taataaggcc ctgcccgctc ctatcgagaa gaccatctcc     660
aaggccaagg gccagcctag agagccacag gtgtacacac tgcctccatc tcgcgatgag     720
ctgaccaaga accaggtgtc cctgacatgt ctggtgaagg gcttctatcc ttccgacatc     780
gctgtggagt gggagagcaa tggccagcca gagaacaatt acaagaccac accccctgtg     840
ctggacagcg atggctcttt ctttctgtat agcaagctga ccgtggacaa gtctcgctgg     900
cagcagggca acgtgtttag ctgttctgtg atgcatgagg ccctgcacaa tcattataca     960
cagaagtccc tgagcctgtc tcctggcaag                                      990

<210> 131
<211> 1417
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7, HBC34-V34, HBC34-V35
      VH-CH1-hinge-CH2-CH3 (codon-optimized)

<400> 131
gagctgcagc tggtggagtc cggcggcggc tgggtgcagc ctggcggctc ccagaggctg      60
agctgtgccg cttctggcag gatcttccgg tccttttaca tgtcttgggt gcggcaggct     120
ccaggcaagg gcctggagtg ggtggctacc atcaaccagg acggctccga gaagctgtat     180
gtggatagcg tgaagggcag attcacaatc tctcgcgaca acgccaagaa ctccctgttt     240
ctgcagatga acaatctgag ggtggaggat accgccgtgt actattgcgc cgcttggtct     300
ggcaatagcg gcggcatgga cgtgtgggga cagggcacca ccgtgtccgt gtccagcgcc     360
tccacaaagg gcccaagcgt gtttccactg gctccctctt ccaagtctac ctccggcggc     420
acagccgctc tgggatgtct ggtgaaggat tacttcccag agcccgtgac cgtgtcttgg     480
aactccggcg ccctgaccag cggagtgcat acatttccag ctgtgctgca gagctctggc     540
ctgtactctc tgtccagcgt ggtgaccgtg ccctcttcca gcctgggcac ccagacatat     600
atctgcaacg tgaatcacaa gccaagcaat acaaaggtgg acaagaaggt ggagcccaag     660
tcttgtgata agacccatac atgccctcca tgtccagctc cagagctgct gggcggccca     720
agcgtgttcc tgtttccacc caagcctaag gataccctga tgatctccag aacccccgag     780
gtgacatgcg tggtggtgga cgtgagccac gaggatcctg aggtgaagtt caactggtac     840
gtggacggcg tggaggtgca taatgctaag accaagccca gggaggagca gtacaactct     900
acctatcggg tggtgtccgt gctgacagtg ctgcaccagg attggctgaa cggcaaggag     960
tataagtgca aggtgtctaa taaggccctg cccgctccta tcgagaagac catctccaag    1020
gccaagggcc agcctagaga gccacaggtg tacacactgc ctccatctcg cgatgagctg    1080
accaagaacc aggtgtccct gacatgtctg gtgaagggct tctatccttc cgacatcgct    1140
gtggagtggg agagcaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg    1200
gacagcgatg gctctttctt tctgtatagc aagctgaccg tggacaagtc tcgctggcag    1260
cagggcaacg tgtttagctg ttctgtgatg catgaggccc tgcacaatca ttatacacag    1320
aagtccctga gcctgtctcc tggcaagtga tgaggtaccg tgcgacggcc ggcaagcccc    1380
cgctccccgg gctctcgcgg tcgtacgagg aaagctt                             1417

<210> 132
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 CL (codon-optimized)

<400> 132
ggacagccaa aggctgctcc atctgtgacc ctgtttccac cctcttccga ggagctgcag      60
gccaacaagg ccaccctggt gtgcctgatc tctgacttct accctggagc tgtgacagtg     120
gcttggaagg ctgatagctc tcccgtgaag gctggcgtgg agacaacaac ccctagcaag     180
cagtctaaca ataagtacgc cgcttccagc tatctgtctc tgacaccaga gcagtggaag     240
tcccaccgct cttattcctg ccaggtgacc catgagggca gcaccgtgga gaagacagtg     300
gcccccaccg agtgttct                                                   318

<210> 133
<211> 636
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V7 LC (VL-CL)
      (codon-optimized)

<400> 133
agctacgagc tgacacagcc cccttccgtg tccgtgtccc ctggacagac cgtgtccatc      60
ccatgcagcg gcgacaagct gggcaacaag aacgtgtgct ggtttcagca taagcctggc     120
cagtcccccg tgctggtcat ctacgaggtg aagtataggc ccagcggcat ccctgagcgg     180
ttctctggct ccaacagcgg caatacagcc accctgacaa tctctggcac acaggctatg     240
gacgaggccg cttatttctg ccagaccttt gattccacca cagtggtgtt cggcggcggc     300
accagactga cagtgctggg acagccaaag gctgctccat ctgtgaccct gtttccaccc     360
tcttccgagg agctgcaggc caacaaggcc accctggtgt gcctgatctc tgacttctac     420
cctggagctg tgacagtggc ttggaaggct gatagctctc ccgtgaaggc tggcgtggag     480
acaacaaccc ctagcaagca gtctaacaat aagtacgccg cttccagcta tctgtctctg     540
acaccagagc agtggaagtc ccaccgctct tattcctgcc aggtgaccca tgagggcagc     600
accgtggaga agacagtggc ccccaccgag tgttct                               636

<210> 134
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V34,  HBC34-V35 CL
      (codon-optimized)
      

<400> 134
ggacagccaa aggctgctcc atctgtgacc ctgtttccac cctcttccga ggagctgcag      60
gccaacaagg ccaccctggt gtgcctgatc tctgacttct accctggagc tgtgacagtg     120
gcttggaagg ctgatagctc tcccgtgaag gctggcgtgg agacaacaac ccctagcaag     180
cagtctaaca ataagtacgc cgcttccagc tatctgtctc tgacaccaga gcagtggaag     240
tcccaccgct cttattcctg ccaggtgacc catgagggca gcaccgtgga gaagacagtg     300
gcccccaccg agtgttct                                                   318

<210> 135
<211> 636
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V34 LC (VL-CL)
      (codon-optimized)

<400> 135
agctacgagc tgacacagcc cccttccgtg tccgtgtccc ctggacagac cgtgtccatc      60
ccatgcagcg gcgacaagct gggcaacaag aacgtgtcct ggtttcagca taagcctggc     120
cagtcccccg tgctggtcat ctacgaggtg aagtataggc ccagcggcat ccctgagcgg     180
ttctctggct ccaacagcgg caatacagcc accctgacaa tctctggcac acaggctatg     240
gacgaggccg cttatttctg ccagaccttt gattccacca cagtggtgtt cggcggcggc     300
accagactga cagtgctggg acagccaaag gctgctccat ctgtgaccct gtttccaccc     360
tcttccgagg agctgcaggc caacaaggcc accctggtgt gcctgatctc tgacttctac     420
cctggagctg tgacagtggc ttggaaggct gatagctctc ccgtgaaggc tggcgtggag     480
acaacaaccc ctagcaagca gtctaacaat aagtacgccg cttccagcta tctgtctctg     540
acaccagagc agtggaagtc ccaccgctct tattcctgcc aggtgaccca tgagggcagc     600
accgtggaga agacagtggc ccccaccgag tgttct                               636

<210> 136
<211> 636
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34-V35 LC (VL-CL)
      (codon-optimized)

<400> 136
agctacgagc tgacacagcc cccttccgtg tccgtgtccc ctggacagac cgtgtccatc      60
ccatgcagcg gcgacaagct gggcaacaag aacgtggcct ggtttcagca taagcctggc     120
cagtcccccg tgctggtcat ctacgaggtg aagtataggc ccagcggcat ccctgagcgg     180
ttctctggct ccaacagcgg caatacagcc accctgacaa tctctggcac acaggctatg     240
gacgaggccg cttatttctg ccagaccttt gattccacca cagtggtgtt cggcggcggc     300
accagactga cagtgctggg acagccaaag gctgctccat ctgtgaccct gtttccaccc     360
tcttccgagg agctgcaggc caacaaggcc accctggtgt gcctgatctc tgacttctac     420
cctggagctg tgacagtggc ttggaaggct gatagctctc ccgtgaaggc tggcgtggag     480
acaacaaccc ctagcaagca gtctaacaat aagtacgccg cttccagcta tctgtctctg     540
acaccagagc agtggaagtc ccaccgctct tattcctgcc aggtgaccca tgagggcagc     600
accgtggaga agacagtggc ccccaccgag tgttct                               636

<210> 137
<211> 217
<212> PRT
<213> Homo sapiens IgG1

<220> 
<223> WT hIgG1 Fc

<400> 137
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 138
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence HBC34, HBC34v7, HBC34v23,
      HBC34v34, HBC34v35, HBC34_C40S, HBC34_C40A,
      HBC34v23_C40S, HBC34v23_C40A      
      HC with GAALIE mutation in hIgG1 Fc
      

<400> 138
Glu Leu Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Gln Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe Arg Ser Phe
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Asn Gln Asp Gly Ser Glu Lys Leu Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ala Trp Ser Gly Asn Ser Gly Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Ala Gly Pro
225                 230                 235                 240
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Leu Pro Glu Glu Lys
                325                 330                 335
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445
Lys


<210> 139
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Chimeric hinge sequence

<400> 139
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15
Ala Gly Pro

