                         SEQUENCE LISTING

<110>  THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW 
       YORK
 
<120>  TARGETED DELIVERY OF TUMOR MATRIX MODIFYING ENZYMES

<130>  011520.01539

<150>  US 62/893,120
<151>  2019-08-28

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Thr Cys Ala Ala Ser Gly Tyr Ile Phe Asn Ser Cys 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ser Pro Gly Arg Glu Arg Glu Leu Val 
        35                  40                  45              


Ser Arg Ile Ser Gly Asp Gly Asp Thr Trp His Lys Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Val Lys Lys Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Val Cys Tyr Asn Leu Glu Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Val Gln Asn Glu Ser Lys Arg Tyr Thr Val Ser Tyr Leu Lys 
    130                 135                 140                 


Thr Leu Asn Tyr Tyr Asp Leu Val Asp Leu Leu Val Lys Thr Glu Ile 
145                 150                 155                 160 


Glu Asn Leu Pro Asp Leu Phe Gln Tyr Ser Ser Asp Ala Lys Glu Phe 
                165                 170                 175     


Tyr Gly Asn Lys Thr Arg Met Ser Phe Ile Met Asp Glu Ile Gly Arg 
            180                 185                 190         


Arg Ala Pro Gln Tyr Thr Glu Ile Asp His Lys Gly Ile Pro Thr Leu 
        195                 200                 205             


Val Glu Val Val Arg Ala Gly Phe Tyr Leu Gly Phe His Asn Lys Glu 
    210                 215                 220                 


Leu Asn Glu Ile Asn Lys Arg Ser Phe Lys Glu Arg Val Ile Pro Ser 
225                 230                 235                 240 


Ile Leu Ala Ile Gln Lys Asn Pro Asn Phe Lys Leu Gly Thr Glu Val 
                245                 250                 255     


Gln Asp Lys Ile Val Ser Ala Thr Gly Leu Leu Ala Gly Asn Glu Thr 
            260                 265                 270         


Ala Pro Pro Glu Val Val Asn Asn Phe Thr Pro Ile Leu Gln Asp Cys 
        275                 280                 285             


Ile Lys Asn Ile Asp Arg Tyr Ala Leu Asp Asp Leu Lys Ser Lys Ala 
    290                 295                 300                 


Leu Phe Asn Val Leu Ala Ala Pro Thr Tyr Asp Ile Thr Glu Tyr Leu 
305                 310                 315                 320 


Arg Ala Thr Lys Glu Lys Pro Glu Asn Thr Pro Trp Tyr Gly Lys Ile 
                325                 330                 335     


Asp Gly Phe Ile Asn Glu Leu Lys Lys Leu Ala Leu Tyr Gly Lys Ile 
            340                 345                 350         


Asn Asp Asn Asn Ser Trp Ile Ile Asp Asn Gly Ile Tyr His Ile Ala 
        355                 360                 365             


Pro Leu Gly Lys Leu His Ser Asn Asn Lys Ile Gly Ile Glu Thr Leu 
    370                 375                 380                 


Thr Glu Val Met Lys Val Tyr Pro Tyr Leu Ser Met Gln His Leu Gln 
385                 390                 395                 400 


Ser Ala Asp Gln Ile Lys Arg His Tyr Asp Ser Lys Asp Ala Glu Gly 
                405                 410                 415     


Asn Lys Ile Pro Leu Asp Lys Phe Lys Lys Glu Gly Lys Glu Lys Tyr 
            420                 425                 430         


Cys Pro Lys Thr Tyr Thr Phe Asp Asp Gly Lys Val Ile Ile Lys Ala 
        435                 440                 445             


Gly Ala Arg Val Glu Glu Glu Lys Val Lys Arg Leu Tyr Trp Ala Ser 
    450                 455                 460                 


Lys Glu Val Asn Ser Gln Phe Phe Arg Val Tyr Gly Ile Asp Lys Pro 
465                 470                 475                 480 


Leu Glu Glu Gly Asn Pro Asp Asp Ile Leu Thr Met Val Ile Tyr Asn 
                485                 490                 495     


Ser Pro Glu Glu Tyr Lys Leu Asn Ser Val Leu Tyr Gly Tyr Asp Thr 
            500                 505                 510         


Asn Asn Gly Gly Met Tyr Ile Glu Pro Glu Gly Thr Phe Phe Thr Tyr 
        515                 520                 525             


Glu Arg Glu Ala Gln Glu Ser Thr Tyr Thr Leu Glu Glu Leu Phe Arg 
    530                 535                 540                 


His Glu Tyr Thr His Tyr Leu Gln Gly Arg Tyr Ala Val Pro Gly Gln 
545                 550                 555                 560 


Trp Gly Arg Thr Lys Leu Tyr Asp Asn Asp Arg Leu Thr Trp Tyr Glu 
                565                 570                 575     


Glu Gly Gly Ala Glu Leu Phe Ala Gly Ser Thr Arg Thr Ser Gly Ile 
            580                 585                 590         


Leu Pro Arg Lys Ser Ile Val Ser Asn Ile His Asn Thr Thr Arg Asn 
        595                 600                 605             


Asn Arg Tyr Lys Leu Ser Asp Thr Val His Ser Lys Tyr Gly Ala Ser 
    610                 615                 620                 


Phe Glu Phe Tyr Asn Tyr Ala Cys Met Phe Met Asp Tyr Met Tyr Asn 
625                 630                 635                 640 


Lys Asp Met Gly Ile Leu Asn Lys Leu Asn Asp Leu Ala Lys Asn Asn 
                645                 650                 655     


Asp Val Asp Gly Tyr Asp Asn Tyr Ile Arg Asp Leu Ser Ser Asn Tyr 
            660                 665                 670         


Ala Leu Asn Asp Lys Tyr Gln Asp His Met Gln Glu Arg Ile Asp Asn 
        675                 680                 685             


Tyr Glu Asn Leu Thr Val Pro Phe Val Ala Asp Asp Tyr Leu Val Arg 
    690                 695                 700                 


His Ala Tyr Lys Asn Pro Asn Glu Ile Tyr Ser Glu Ile Ser Glu Val 
705                 710                 715                 720 


Ala Lys Leu Lys Asp Ala Lys Ser Glu Val Lys Lys Ser Gln Tyr Phe 
                725                 730                 735     


Ser Thr Phe Thr Leu Arg Gly Ser Tyr Thr Gly Gly Ala Ser Lys Gly 
            740                 745                 750         


Lys Leu Glu Asp Gln Lys Ala Met Asn Lys Phe Ile Asp Asp Ser Leu 
        755                 760                 765             


Lys Lys Leu Asp Thr Tyr Ser Trp Ser Gly Tyr Lys Thr Leu Thr Ala 
    770                 775                 780                 


Tyr Phe Thr Asn Tyr Lys Val Asp Ser Ser Asn Arg Val Thr Tyr Asp 
785                 790                 795                 800 


Val Val Phe His Gly Tyr Leu Pro Asn Glu Gly Asp Ser Lys Asn Ser 
                805                 810                 815     


Leu Pro Tyr Gly Lys Ile Asn Gly Thr Tyr Lys Gly Thr Glu Lys Glu 
            820                 825                 830         


Lys Ile Lys Phe Ser Ser Glu Gly Ser Phe Asp Pro Asp Gly Lys Ile 
        835                 840                 845             


Val Ser Tyr Glu Trp Asp Phe Gly Asp Gly Asn Lys Ser Asn Glu Glu 
    850                 855                 860                 


Asn Pro Glu His Ser Tyr Asp Lys Val Gly Thr Tyr Thr Val Lys Leu 
865                 870                 875                 880 


Lys Val Thr Asp Asp Lys Gly Glu Ser Ser Val Ser Thr Thr Thr Ala 
                885                 890                 895     


Glu Ile Lys Asp Leu Ser Glu Asn Lys Leu Pro Val Ile Tyr Met His 
            900                 905                 910         


Val Pro Lys Ser Gly Ala Leu Asn Gln Lys Val Val Phe Tyr Gly Lys 
        915                 920                 925             


Gly Thr Tyr Asp Pro Asp Gly Ser Ile Ala Gly Tyr Gln Trp Asp Phe 
    930                 935                 940                 


Gly Asp Gly Ser Asp Phe Ser Ser Glu Gln Asn Pro Ser His Val Tyr 
945                 950                 955                 960 


Thr Lys Lys Gly Glu Tyr Thr Val Thr Leu Arg Val Met Asp Ser Ser 
                965                 970                 975     


Gly Gln Met Ser Glu Lys Thr Met Lys Ile Lys Ile Thr Asp Pro Val 
            980                 985                 990         


Tyr Pro Ile Gly Thr Glu Lys Glu  Pro Asn Asn Ser Lys  Glu Thr Ala 
        995                 1000                 1005             


Ser Gly  Pro Ile Val Pro Gly  Ile Pro Val Ser Gly  Thr Ile Glu 
    1010                 1015                 1020             


Asn Thr  Ser Asp Gln Asp Tyr  Phe Tyr Phe Asp Val  Ile Thr Pro 
    1025                 1030                 1035             


Gly Glu  Val Lys Ile Asp Ile  Asn Lys Leu Gly Tyr  Gly Gly Ala 
    1040                 1045                 1050             


Thr Trp  Val Val Tyr Asp Glu  Asn Asn Asn Ala Val  Ser Tyr Ala 
    1055                 1060                 1065             


Thr Asp  Asp Gly Gln Asn Leu  Ser Gly Lys Phe Lys  Ala Asp Lys 
    1070                 1075                 1080             


Pro Gly  Arg Tyr Tyr Ile His  Leu Tyr Met Phe Asn  Gly Ser Tyr 
    1085                 1090                 1095             


Met Pro  Tyr Arg Ile Asn Ile  Glu Leu Glu His His  His His His 
    1100                 1105                 1110             


His 
    


<210>  2
<211>  3336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence encoding fusion protein

<400>  2
catatgcagg ttcagctgca agaaagcggt ggtggtagcg ttcaggcagg cggtagcctg       60

aaactgacct gtgcagcaag cggttatatc tttaatagct gtggtatggg ttggtatcgt      120

cagagtccgg gtcgtgaacg tgaactggtt agccgtatta gcggtgatgg tgatacctgg      180

cataaagaaa gcgttaaagg tcgttttacc atcagccagg ataacgtgaa aaaaaccctg      240

tacctgcaga tgaatagtct gaaaccggaa gataccgcag tgtatttttg tgccgtttgc      300

tataatctgg aaacctattg gggtcagggc acccaggtta ccgttagctc aggtggtggt      360

ggcagcggtg gcggtggttc tggtggcgga ggtagcgtgc agaatgaaag caaacgttat      420

accgtgagct atctgaaaac cctgaactat tatgatctgg ttgatctgct ggtgaaaacc      480

gaaattgaaa atctgccgga cctgtttcag tatagcagtg atgcaaaaga attctacggt      540

aataaaaccc gcatgagctt tatcatggat gaaattggtc gtcgtgcacc gcagtataca      600

gaaattgatc ataaaggtat tccgacgctg gttgaagttg ttcgtgcagg tttttatctg      660

ggctttcata acaaagaact gaacgagatt aacaaacgca gctttaaaga acgtgtgatt      720

ccgagcattc tggccattca gaaaaatccg aactttaaac tgggcaccga agtgcaggat      780

aaaattgtta gcgcaaccgg tctgctggcg ggtaacgaga ccgcgccgcc ggaagtggtt      840

aacaacttta ccccgattct gcaggactgc attaaaaaca ttgaccgtta tgcgctggat      900

gacctgaaga gcaaagcgct gtttaacgtt ctggcggcgc cgacctatga cattaccgag      960

tatctgcgtg cgaccaagga gaaaccggaa aacaccccgt ggtacggcaa aatcgatggt     1020

ttcattaacg agctgaaaaa gctggcgctg tacggtaaaa tcaacgacaa caacagctgg     1080

atcattgaca acggtattta ccacatcgcg ccgctgggca aactgcacag caacaacaag     1140

atcggcattg agaccctgac cgaagttatg aaggtgtacc cgtatctgag catgcaacac     1200

ctgcagagcg cggatcaaat caaacgtcac tacgatagca aggacgcgga aggcaacaaa     1260

atcccgctgg acaaattcaa gaaagaaggc aaggagaaat actgcccgaa aacctatacc     1320

tttgatgacg gcaaggttat tatcaaggcg ggtgcgcgtg tggaagaaga gaaggtgaaa     1380

cgtctgtatt gggcgagcaa ggaagtgaac agccagttct ttcgtgttta tggcattgat     1440

aaaccgctgg aggaaggtaa cccggatgac atcctgacca tggtgatcta caacagcccg     1500

gaagagtaca aactgaacag cgtgctgtac ggctacgaca ccaacaacgg tggcatgtac     1560

attgagccgg aaggtacctt tttcacctat gaacgtgagg cgcaggagag cacctatacc     1620

ctggaggagc tgttccgtca cgagtatacc cactatctgc aaggtcgtta tgcggtgccg     1680

ggccagtggg gtcgtaccaa actgtacgat aacgaccgtc tgacctggta tgaggaaggc     1740

ggtgcggagc tgttcgcggg tagcacccgt accagcggta ttctgccgcg taagagcatc     1800

gttagcaaca ttcacaacac cacccgtaac aaccgttaca agctgagcga caccgtgcac     1860

agcaagtatg gcgcgagctt cgaattctac aactacgcgt gcatgttcat ggactatatg     1920

tacaacaagg acatgggcat tctgaacaaa ctgaacgacc tggcgaagaa caacgatgtt     1980

gacggttacg acaactacat tcgtgatctg agcagcaact atgcgctgaa cgacaagtat     2040

caggaccaca tgcaggagcg tattgacaac tacgagaacc tgaccgttcc gtttgttgcg     2100

gacgattacc tggttcgtca cgcgtacaag aacccgaacg aaatttatag cgaaatcagc     2160

gaggtggcga aactgaagga tgcgaaaagc gaggttaaaa agagccaata cttcagcacc     2220

ttcaccctgc gtggtagcta taccggcggc gcgagcaagg gcaaactgga ggaccagaaa     2280

gcgatgaaca agttcatcga cgatagcctg aagaagctgg acacctatag ctggagcggt     2340

tacaaaaccc tgaccgcgta cttcaccaac tataaagttg acagcagcaa ccgtgtgacc     2400

tatgacgttg tgtttcacgg ttatctgccg aacgaaggcg atagcaagaa cagcctgccg     2460

tatggtaaaa tcaacggcac ctacaagggt accgaaaagg agaaaatcaa gtttagcagc     2520

gaaggtagct tcgacccgga tggcaaaatc gtgagctacg aatgggattt tggtgacggt     2580

aacaaaagca acgaagaaaa cccggaacac agctacgata aagttggtac ctacaccgtg     2640

aaactgaaag tgaccgatga caagggcgaa agcagcgtta gcaccaccac cgcggagatc     2700

aaagatctga gcgagaacaa actgccggtg atctacatgc acgttccgaa aagcggtgcg     2760

ctgaaccaga aagttgtgtt ctatggcaaa ggcacctacg atccggacgg tagcatcgcg     2820

ggctaccagt gggacttcgg cgatggcagc gattttagca gcgagcagaa cccgagccac     2880

gtgtatacca agaaaggcga atataccgtg accctgcgtg ttatggacag cagcggtcag     2940

atgagcgaga agaccatgaa aatcaagatt accgatccgg tttacccgat tggtaccgag     3000

aaggaaccga acaacagcaa ggaaaccgcg agcggtccga ttgtgccggg tattccggtt     3060

agcggcacca tcgagaacac cagcgaccaa gattattttt acttcgatgt tatcaccccg     3120

ggcgaggtga agatcgatat taacaaactg ggttacggtt acggtggcgc gacctgggtg     3180

gtttatgacg agaacaacaa cgcggttagc tacgcgaccg acgatggcca gaacctgagc     3240

ggcaagttta aagcggataa gccgggccgt tactacatcc acctgtatat gtttaacggt     3300

agctacatgc cgtaccgtat caacattgag ctcgag                               3336


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  3

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Thr Cys Ala Ala Ser Gly Tyr Ile Phe Asn Ser Cys 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ser Pro Gly Arg Glu Arg Glu Leu Val 
        35                  40                  45              


Ser Arg Ile Ser Gly Asp Gly Asp Thr Trp His Lys Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Val Lys Lys Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Val Cys Tyr Asn Leu Glu Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  4
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sdAb

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Asp 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Asp Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Thr Gly Tyr Gly Val Thr Lys Thr Pro Thr Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  5
<211>  912
<212>  PRT
<213>  Clostridium histolyticum

<400>  5

Val Gln Asn Glu Ser Lys Arg Tyr Thr Val Ser Tyr Leu Lys Thr Leu 
1               5                   10                  15      


Asn Tyr Tyr Asp Leu Val Asp Leu Leu Val Lys Thr Glu Ile Glu Asn 
            20                  25                  30          


Leu Pro Asp Leu Phe Gln Tyr Ser Ser Asp Ala Lys Glu Phe Tyr Gly 
        35                  40                  45              


Asn Lys Thr Arg Met Ser Phe Ile Met Asp Glu Ile Gly Arg Arg Ala 
    50                  55                  60                  


Pro Gln Tyr Thr Glu Ile Asp His Lys Gly Ile Pro Thr Leu Val Glu 
65                  70                  75                  80  


Val Val Arg Ala Gly Phe Tyr Leu Gly Phe His Asn Lys Glu Leu Asn 
                85                  90                  95      


Glu Ile Asn Lys Arg Ser Phe Lys Glu Arg Val Ile Pro Ser Ile Leu 
            100                 105                 110         


Ala Ile Gln Lys Asn Pro Asn Phe Lys Leu Gly Thr Glu Val Gln Asp 
        115                 120                 125             


Lys Ile Val Ser Ala Thr Gly Leu Leu Ala Gly Asn Glu Thr Ala Pro 
    130                 135                 140                 


Pro Glu Val Val Asn Asn Phe Thr Pro Ile Leu Gln Asp Cys Ile Lys 
145                 150                 155                 160 


Asn Ile Asp Arg Tyr Ala Leu Asp Asp Leu Lys Ser Lys Ala Leu Phe 
                165                 170                 175     


Asn Val Leu Ala Ala Pro Thr Tyr Asp Ile Thr Glu Tyr Leu Arg Ala 
            180                 185                 190         


Thr Lys Glu Lys Pro Glu Asn Thr Pro Trp Tyr Gly Lys Ile Asp Gly 
        195                 200                 205             


Phe Ile Asn Glu Leu Lys Lys Leu Ala Leu Tyr Gly Lys Ile Asn Asp 
    210                 215                 220                 


Asn Asn Ser Trp Ile Ile Asp Asn Gly Ile Tyr His Ile Ala Pro Leu 
225                 230                 235                 240 


Gly Lys Leu His Ser Asn Asn Lys Ile Gly Ile Glu Thr Leu Thr Glu 
                245                 250                 255     


Val Met Lys Val Tyr Pro Tyr Leu Ser Met Gln His Leu Gln Ser Ala 
            260                 265                 270         


Asp Gln Ile Lys Arg His Tyr Asp Ser Lys Asp Ala Glu Gly Asn Lys 
        275                 280                 285             


Ile Pro Leu Asp Lys Phe Lys Lys Glu Gly Lys Glu Lys Tyr Cys Pro 
    290                 295                 300                 


Lys Thr Tyr Thr Phe Asp Asp Gly Lys Val Ile Ile Lys Ala Gly Ala 
305                 310                 315                 320 


Arg Val Glu Glu Glu Lys Val Lys Arg Leu Tyr Trp Ala Ser Lys Glu 
                325                 330                 335     


Val Asn Ser Gln Phe Phe Arg Val Tyr Gly Ile Asp Lys Pro Leu Glu 
            340                 345                 350         


Glu Gly Asn Pro Asp Asp Ile Leu Thr Met Val Ile Tyr Asn Ser Pro 
        355                 360                 365             


Glu Glu Tyr Lys Leu Asn Ser Val Leu Tyr Gly Tyr Asp Thr Asn Asn 
    370                 375                 380                 


Gly Gly Met Tyr Ile Glu Pro Glu Gly Thr Phe Phe Thr Tyr Glu Arg 
385                 390                 395                 400 


Glu Ala Gln Glu Ser Thr Tyr Thr Leu Glu Glu Leu Phe Arg His Glu 
                405                 410                 415     


Tyr Thr His Tyr Leu Gln Gly Arg Tyr Ala Val Pro Gly Gln Trp Gly 
            420                 425                 430         


Arg Thr Lys Leu Tyr Asp Asn Asp Arg Leu Thr Trp Tyr Glu Glu Gly 
        435                 440                 445             


Gly Ala Glu Leu Phe Ala Gly Ser Thr Arg Thr Ser Gly Ile Leu Pro 
    450                 455                 460                 


Arg Lys Ser Ile Val Ser Asn Ile His Asn Thr Thr Arg Asn Asn Arg 
465                 470                 475                 480 


Tyr Lys Leu Ser Asp Thr Val His Ser Lys Tyr Gly Ala Ser Phe Glu 
                485                 490                 495     


Phe Tyr Asn Tyr Ala Cys Met Phe Met Asp Tyr Met Tyr Asn Lys Asp 
            500                 505                 510         


Met Gly Ile Leu Asn Lys Leu Asn Asp Leu Ala Lys Asn Asn Asp Val 
        515                 520                 525             


Asp Gly Tyr Asp Asn Tyr Ile Arg Asp Leu Ser Ser Asn Tyr Ala Leu 
    530                 535                 540                 


Asn Asp Lys Tyr Gln Asp His Met Gln Glu Arg Ile Asp Asn Tyr Glu 
545                 550                 555                 560 


Asn Leu Thr Val Pro Phe Val Ala Asp Asp Tyr Leu Val Arg His Ala 
                565                 570                 575     


Tyr Lys Asn Pro Asn Glu Ile Tyr Ser Glu Ile Ser Glu Val Ala Lys 
            580                 585                 590         


Leu Lys Asp Ala Lys Ser Glu Val Lys Lys Ser Gln Tyr Phe Ser Thr 
        595                 600                 605             


Phe Thr Leu Arg Gly Ser Tyr Thr Gly Gly Ala Ser Lys Gly Lys Leu 
    610                 615                 620                 


Glu Asp Gln Lys Ala Met Asn Lys Phe Ile Asp Asp Ser Leu Lys Lys 
625                 630                 635                 640 


Leu Asp Thr Tyr Ser Trp Ser Gly Tyr Lys Thr Leu Thr Ala Tyr Phe 
                645                 650                 655     


Thr Asn Tyr Lys Val Asp Ser Ser Asn Arg Val Thr Tyr Asp Val Val 
            660                 665                 670         


Phe His Gly Tyr Leu Pro Asn Glu Gly Asp Ser Lys Asn Ser Leu Pro 
        675                 680                 685             


Tyr Gly Lys Ile Asn Gly Thr Tyr Lys Gly Thr Glu Lys Glu Lys Ile 
    690                 695                 700                 


Lys Phe Ser Ser Glu Gly Ser Phe Asp Pro Asp Gly Lys Ile Val Ser 
705                 710                 715                 720 


Tyr Glu Trp Asp Phe Gly Asp Gly Asn Lys Ser Asn Glu Glu Asn Pro 
                725                 730                 735     


Glu His Ser Tyr Asp Lys Val Gly Thr Tyr Thr Val Lys Leu Lys Val 
            740                 745                 750         


Thr Asp Asp Lys Gly Glu Ser Ser Val Ser Thr Thr Thr Ala Glu Ile 
        755                 760                 765             


Lys Asp Leu Ser Glu Asn Lys Leu Pro Val Ile Tyr Met His Val Pro 
    770                 775                 780                 


Lys Ser Gly Ala Leu Asn Gln Lys Val Val Phe Tyr Gly Lys Gly Thr 
785                 790                 795                 800 


Tyr Asp Pro Asp Gly Ser Ile Ala Gly Tyr Gln Trp Asp Phe Gly Asp 
                805                 810                 815     


Gly Ser Asp Phe Ser Ser Glu Gln Asn Pro Ser His Val Tyr Thr Lys 
            820                 825                 830         


Lys Gly Glu Tyr Thr Val Thr Leu Arg Val Met Asp Ser Ser Gly Gln 
        835                 840                 845             


Met Ser Glu Lys Thr Met Lys Ile Lys Ile Thr Asp Pro Val Tyr Pro 
    850                 855                 860                 


Ile Gly Thr Glu Lys Glu Pro Asn Asn Ser Lys Glu Thr Ala Ser Gly 
865                 870                 875                 880 


Pro Ile Val Pro Gly Ile Pro Val Ser Gly Thr Ile Glu Asn Thr Ser 
                885                 890                 895     


Asp Gln Asp Tyr Phe Tyr Phe Asp Val Ile Thr Pro Gly Glu Val Lys 
            900                 905                 910         


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  6

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  7
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  7

Gly Gly Gly Ser Gly Gly Gly Ser Leu Glu Val Leu Phe Gln Gly Pro 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  8
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABD035

<400>  8

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Phe Tyr Lys Arg Leu Ile Asn Lys Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Glu Ala Leu Lys Leu His Ile Leu Ala Ala Leu Pro 
        35                  40                  45      


<210>  9
<211>  1175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Thr Cys Ala Ala Ser Gly Tyr Ile Phe Asn Ser Cys 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ser Pro Gly Arg Glu Arg Glu Leu Val 
        35                  40                  45              


Ser Arg Ile Ser Gly Asp Gly Asp Thr Trp His Lys Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Asn Val Lys Lys Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Val Cys Tyr Asn Leu Glu Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Val 
        115                 120                 125             


Gln Asn Glu Ser Lys Arg Tyr Thr Val Ser Tyr Leu Lys Thr Leu Asn 
    130                 135                 140                 


Tyr Tyr Asp Leu Val Asp Leu Leu Val Lys Thr Glu Ile Glu Asn Leu 
145                 150                 155                 160 


Pro Asp Leu Phe Gln Tyr Ser Ser Asp Ala Lys Glu Phe Tyr Gly Asn 
                165                 170                 175     


Lys Thr Arg Met Ser Phe Ile Met Asp Glu Ile Gly Arg Arg Ala Pro 
            180                 185                 190         


Gln Tyr Thr Glu Ile Asp His Lys Gly Ile Pro Thr Leu Val Glu Val 
        195                 200                 205             


Val Arg Ala Gly Phe Tyr Leu Gly Phe His Asn Lys Glu Leu Asn Glu 
    210                 215                 220                 


Ile Asn Lys Arg Ser Phe Lys Glu Arg Val Ile Pro Ser Ile Leu Ala 
225                 230                 235                 240 


Ile Gln Lys Asn Pro Asn Phe Lys Leu Gly Thr Glu Val Gln Asp Lys 
                245                 250                 255     


Ile Val Ser Ala Thr Gly Leu Leu Ala Gly Asn Glu Thr Ala Pro Pro 
            260                 265                 270         


Glu Val Val Asn Asn Phe Thr Pro Ile Leu Gln Asp Cys Ile Lys Asn 
        275                 280                 285             


Ile Asp Arg Tyr Ala Leu Asp Asp Leu Lys Ser Lys Ala Leu Phe Asn 
    290                 295                 300                 


Val Leu Ala Ala Pro Thr Tyr Asp Ile Thr Glu Tyr Leu Arg Ala Thr 
305                 310                 315                 320 


Lys Glu Lys Pro Glu Asn Thr Pro Trp Tyr Gly Lys Ile Asp Gly Phe 
                325                 330                 335     


Ile Asn Glu Leu Lys Lys Leu Ala Leu Tyr Gly Lys Ile Asn Asp Asn 
            340                 345                 350         


Asn Ser Trp Ile Ile Asp Asn Gly Ile Tyr His Ile Ala Pro Leu Gly 
        355                 360                 365             


Lys Leu His Ser Asn Asn Lys Ile Gly Ile Glu Thr Leu Thr Glu Val 
    370                 375                 380                 


Met Lys Val Tyr Pro Tyr Leu Ser Met Gln His Leu Gln Ser Ala Asp 
385                 390                 395                 400 


Gln Ile Lys Arg His Tyr Asp Ser Lys Asp Ala Glu Gly Asn Lys Ile 
                405                 410                 415     


Pro Leu Asp Lys Phe Lys Lys Glu Gly Lys Glu Lys Tyr Cys Pro Lys 
            420                 425                 430         


Thr Tyr Thr Phe Asp Asp Gly Lys Val Ile Ile Lys Ala Gly Ala Arg 
        435                 440                 445             


Val Glu Glu Glu Lys Val Lys Arg Leu Tyr Trp Ala Ser Lys Glu Val 
    450                 455                 460                 


Asn Ser Gln Phe Phe Arg Val Tyr Gly Ile Asp Lys Pro Leu Glu Glu 
465                 470                 475                 480 


Gly Asn Pro Asp Asp Ile Leu Thr Met Val Ile Tyr Asn Ser Pro Glu 
                485                 490                 495     


Glu Tyr Lys Leu Asn Ser Val Leu Tyr Gly Tyr Asp Thr Asn Asn Gly 
            500                 505                 510         


Gly Met Tyr Ile Glu Pro Glu Gly Thr Phe Phe Thr Tyr Glu Arg Glu 
        515                 520                 525             


Ala Gln Glu Ser Thr Tyr Thr Leu Glu Glu Leu Phe Arg His Glu Tyr 
    530                 535                 540                 


Thr His Tyr Leu Gln Gly Arg Tyr Ala Val Pro Gly Gln Trp Gly Arg 
545                 550                 555                 560 


Thr Lys Leu Tyr Asp Asn Asp Arg Leu Thr Trp Tyr Glu Glu Gly Gly 
                565                 570                 575     


Ala Glu Leu Phe Ala Gly Ser Thr Arg Thr Ser Gly Ile Leu Pro Arg 
            580                 585                 590         


Lys Ser Ile Val Ser Asn Ile His Asn Thr Thr Arg Asn Asn Arg Tyr 
        595                 600                 605             


Lys Leu Ser Asp Thr Val His Ser Lys Tyr Gly Ala Ser Phe Glu Phe 
    610                 615                 620                 


Tyr Asn Tyr Ala Cys Met Phe Met Asp Tyr Met Tyr Asn Lys Asp Met 
625                 630                 635                 640 


Gly Ile Leu Asn Lys Leu Asn Asp Leu Ala Lys Asn Asn Asp Val Asp 
                645                 650                 655     


Gly Tyr Asp Asn Tyr Ile Arg Asp Leu Ser Ser Asn Tyr Ala Leu Asn 
            660                 665                 670         


Asp Lys Tyr Gln Asp His Met Gln Glu Arg Ile Asp Asn Tyr Glu Asn 
        675                 680                 685             


Leu Thr Val Pro Phe Val Ala Asp Asp Tyr Leu Val Arg His Ala Tyr 
    690                 695                 700                 


Lys Asn Pro Asn Glu Ile Tyr Ser Glu Ile Ser Glu Val Ala Lys Leu 
705                 710                 715                 720 


Lys Asp Ala Lys Ser Glu Val Lys Lys Ser Gln Tyr Phe Ser Thr Phe 
                725                 730                 735     


Thr Leu Arg Gly Ser Tyr Thr Gly Gly Ala Ser Lys Gly Lys Leu Glu 
            740                 745                 750         


Asp Gln Lys Ala Met Asn Lys Phe Ile Asp Asp Ser Leu Lys Lys Leu 
        755                 760                 765             


Asp Thr Tyr Ser Trp Ser Gly Tyr Lys Thr Leu Thr Ala Tyr Phe Thr 
    770                 775                 780                 


Asn Tyr Lys Val Asp Ser Ser Asn Arg Val Thr Tyr Asp Val Val Phe 
785                 790                 795                 800 


His Gly Tyr Leu Pro Asn Glu Gly Asp Ser Lys Asn Ser Leu Pro Tyr 
                805                 810                 815     


Gly Lys Ile Asn Gly Thr Tyr Lys Gly Thr Glu Lys Glu Lys Ile Lys 
            820                 825                 830         


Phe Ser Ser Glu Gly Ser Phe Asp Pro Asp Gly Lys Ile Val Ser Tyr 
        835                 840                 845             


Glu Trp Asp Phe Gly Asp Gly Asn Lys Ser Asn Glu Glu Asn Pro Glu 
    850                 855                 860                 


His Ser Tyr Asp Lys Val Gly Thr Tyr Thr Val Lys Leu Lys Val Thr 
865                 870                 875                 880 


Asp Asp Lys Gly Glu Ser Ser Val Ser Thr Thr Thr Ala Glu Ile Lys 
                885                 890                 895     


Asp Leu Ser Glu Asn Lys Leu Pro Val Ile Tyr Met His Val Pro Lys 
            900                 905                 910         


Ser Gly Ala Leu Asn Gln Lys Val Val Phe Tyr Gly Lys Gly Thr Tyr 
        915                 920                 925             


Asp Pro Asp Gly Ser Ile Ala Gly Tyr Gln Trp Asp Phe Gly Asp Gly 
    930                 935                 940                 


Ser Asp Phe Ser Ser Glu Gln Asn Pro Ser His Val Tyr Thr Lys Lys 
945                 950                 955                 960 


Gly Glu Tyr Thr Val Thr Leu Arg Val Met Asp Ser Ser Gly Gln Met 
                965                 970                 975     


Ser Glu Lys Thr Met Lys Ile Lys Ile Thr Asp Pro Val Tyr Pro Ile 
            980                 985                 990         


Gly Thr Glu Lys Glu Pro Asn Asn  Ser Lys Glu Thr Ala  Ser Gly Pro 
        995                 1000                 1005             


Ile Val  Pro Gly Ile Pro Val  Ser Gly Thr Ile Glu  Asn Thr Ser 
    1010                 1015                 1020             


Asp Gln  Asp Tyr Phe Tyr Phe  Asp Val Ile Thr Pro  Gly Glu Val 
    1025                 1030                 1035             


Lys Ile  Asp Ile Asn Lys Leu  Gly Tyr Gly Gly Ala  Thr Trp Val 
    1040                 1045                 1050             


Val Tyr  Asp Glu Asn Asn Asn  Ala Val Ser Tyr Ala  Thr Asp Asp 
    1055                 1060                 1065             


Gly Gln  Asn Leu Ser Gly Lys  Phe Lys Ala Asp Lys  Pro Gly Arg 
    1070                 1075                 1080             


Tyr Tyr  Ile His Leu Tyr Met  Phe Asn Gly Ser Tyr  Met Pro Tyr 
    1085                 1090                 1095             


Arg Ile  Asn Ile Glu Gly Gly  Gly Ser Gly Gly Gly  Ser Leu Glu 
    1100                 1105                 1110             


Val Leu  Phe Gln Gly Pro Gly  Gly Gly Ser Leu Ala  Glu Ala Lys 
    1115                 1120                 1125             


Val Leu  Ala Asn Arg Glu Leu  Asp Lys Tyr Gly Val  Ser Asp Phe 
    1130                 1135                 1140             


Tyr Lys  Arg Leu Ile Asn Lys  Ala Lys Thr Val Glu  Gly Val Glu 
    1145                 1150                 1155             


Ala Leu  Lys Leu His Ile Leu  Ala Ala Leu Pro His  His His His 
    1160                 1165                 1170             


His His  
    1175 


<210>  10
<211>  1177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Asp 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Thr His Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Asp Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Thr Gly Tyr Gly Val Thr Lys Thr Pro Thr Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Val Gln Asn Glu Ser Lys Arg Tyr Thr Val Ser Tyr Leu Lys Thr 
    130                 135                 140                 


Leu Asn Tyr Tyr Asp Leu Val Asp Leu Leu Val Lys Thr Glu Ile Glu 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Phe Gln Tyr Ser Ser Asp Ala Lys Glu Phe Tyr 
                165                 170                 175     


Gly Asn Lys Thr Arg Met Ser Phe Ile Met Asp Glu Ile Gly Arg Arg 
            180                 185                 190         


Ala Pro Gln Tyr Thr Glu Ile Asp His Lys Gly Ile Pro Thr Leu Val 
        195                 200                 205             


Glu Val Val Arg Ala Gly Phe Tyr Leu Gly Phe His Asn Lys Glu Leu 
    210                 215                 220                 


Asn Glu Ile Asn Lys Arg Ser Phe Lys Glu Arg Val Ile Pro Ser Ile 
225                 230                 235                 240 


Leu Ala Ile Gln Lys Asn Pro Asn Phe Lys Leu Gly Thr Glu Val Gln 
                245                 250                 255     


Asp Lys Ile Val Ser Ala Thr Gly Leu Leu Ala Gly Asn Glu Thr Ala 
            260                 265                 270         


Pro Pro Glu Val Val Asn Asn Phe Thr Pro Ile Leu Gln Asp Cys Ile 
        275                 280                 285             


Lys Asn Ile Asp Arg Tyr Ala Leu Asp Asp Leu Lys Ser Lys Ala Leu 
    290                 295                 300                 


Phe Asn Val Leu Ala Ala Pro Thr Tyr Asp Ile Thr Glu Tyr Leu Arg 
305                 310                 315                 320 


Ala Thr Lys Glu Lys Pro Glu Asn Thr Pro Trp Tyr Gly Lys Ile Asp 
                325                 330                 335     


Gly Phe Ile Asn Glu Leu Lys Lys Leu Ala Leu Tyr Gly Lys Ile Asn 
            340                 345                 350         


Asp Asn Asn Ser Trp Ile Ile Asp Asn Gly Ile Tyr His Ile Ala Pro 
        355                 360                 365             


Leu Gly Lys Leu His Ser Asn Asn Lys Ile Gly Ile Glu Thr Leu Thr 
    370                 375                 380                 


Glu Val Met Lys Val Tyr Pro Tyr Leu Ser Met Gln His Leu Gln Ser 
385                 390                 395                 400 


Ala Asp Gln Ile Lys Arg His Tyr Asp Ser Lys Asp Ala Glu Gly Asn 
                405                 410                 415     


Lys Ile Pro Leu Asp Lys Phe Lys Lys Glu Gly Lys Glu Lys Tyr Cys 
            420                 425                 430         


Pro Lys Thr Tyr Thr Phe Asp Asp Gly Lys Val Ile Ile Lys Ala Gly 
        435                 440                 445             


Ala Arg Val Glu Glu Glu Lys Val Lys Arg Leu Tyr Trp Ala Ser Lys 
    450                 455                 460                 


Glu Val Asn Ser Gln Phe Phe Arg Val Tyr Gly Ile Asp Lys Pro Leu 
465                 470                 475                 480 


Glu Glu Gly Asn Pro Asp Asp Ile Leu Thr Met Val Ile Tyr Asn Ser 
                485                 490                 495     


Pro Glu Glu Tyr Lys Leu Asn Ser Val Leu Tyr Gly Tyr Asp Thr Asn 
            500                 505                 510         


Asn Gly Gly Met Tyr Ile Glu Pro Glu Gly Thr Phe Phe Thr Tyr Glu 
        515                 520                 525             


Arg Glu Ala Gln Glu Ser Thr Tyr Thr Leu Glu Glu Leu Phe Arg His 
    530                 535                 540                 


Glu Tyr Thr His Tyr Leu Gln Gly Arg Tyr Ala Val Pro Gly Gln Trp 
545                 550                 555                 560 


Gly Arg Thr Lys Leu Tyr Asp Asn Asp Arg Leu Thr Trp Tyr Glu Glu 
                565                 570                 575     


Gly Gly Ala Glu Leu Phe Ala Gly Ser Thr Arg Thr Ser Gly Ile Leu 
            580                 585                 590         


Pro Arg Lys Ser Ile Val Ser Asn Ile His Asn Thr Thr Arg Asn Asn 
        595                 600                 605             


Arg Tyr Lys Leu Ser Asp Thr Val His Ser Lys Tyr Gly Ala Ser Phe 
    610                 615                 620                 


Glu Phe Tyr Asn Tyr Ala Cys Met Phe Met Asp Tyr Met Tyr Asn Lys 
625                 630                 635                 640 


Asp Met Gly Ile Leu Asn Lys Leu Asn Asp Leu Ala Lys Asn Asn Asp 
                645                 650                 655     


Val Asp Gly Tyr Asp Asn Tyr Ile Arg Asp Leu Ser Ser Asn Tyr Ala 
            660                 665                 670         


Leu Asn Asp Lys Tyr Gln Asp His Met Gln Glu Arg Ile Asp Asn Tyr 
        675                 680                 685             


Glu Asn Leu Thr Val Pro Phe Val Ala Asp Asp Tyr Leu Val Arg His 
    690                 695                 700                 


Ala Tyr Lys Asn Pro Asn Glu Ile Tyr Ser Glu Ile Ser Glu Val Ala 
705                 710                 715                 720 


Lys Leu Lys Asp Ala Lys Ser Glu Val Lys Lys Ser Gln Tyr Phe Ser 
                725                 730                 735     


Thr Phe Thr Leu Arg Gly Ser Tyr Thr Gly Gly Ala Ser Lys Gly Lys 
            740                 745                 750         


Leu Glu Asp Gln Lys Ala Met Asn Lys Phe Ile Asp Asp Ser Leu Lys 
        755                 760                 765             


Lys Leu Asp Thr Tyr Ser Trp Ser Gly Tyr Lys Thr Leu Thr Ala Tyr 
    770                 775                 780                 


Phe Thr Asn Tyr Lys Val Asp Ser Ser Asn Arg Val Thr Tyr Asp Val 
785                 790                 795                 800 


Val Phe His Gly Tyr Leu Pro Asn Glu Gly Asp Ser Lys Asn Ser Leu 
                805                 810                 815     


Pro Tyr Gly Lys Ile Asn Gly Thr Tyr Lys Gly Thr Glu Lys Glu Lys 
            820                 825                 830         


Ile Lys Phe Ser Ser Glu Gly Ser Phe Asp Pro Asp Gly Lys Ile Val 
        835                 840                 845             


Ser Tyr Glu Trp Asp Phe Gly Asp Gly Asn Lys Ser Asn Glu Glu Asn 
    850                 855                 860                 


Pro Glu His Ser Tyr Asp Lys Val Gly Thr Tyr Thr Val Lys Leu Lys 
865                 870                 875                 880 


Val Thr Asp Asp Lys Gly Glu Ser Ser Val Ser Thr Thr Thr Ala Glu 
                885                 890                 895     


Ile Lys Asp Leu Ser Glu Asn Lys Leu Pro Val Ile Tyr Met His Val 
            900                 905                 910         


Pro Lys Ser Gly Ala Leu Asn Gln Lys Val Val Phe Tyr Gly Lys Gly 
        915                 920                 925             


Thr Tyr Asp Pro Asp Gly Ser Ile Ala Gly Tyr Gln Trp Asp Phe Gly 
    930                 935                 940                 


Asp Gly Ser Asp Phe Ser Ser Glu Gln Asn Pro Ser His Val Tyr Thr 
945                 950                 955                 960 


Lys Lys Gly Glu Tyr Thr Val Thr Leu Arg Val Met Asp Ser Ser Gly 
                965                 970                 975     


Gln Met Ser Glu Lys Thr Met Lys Ile Lys Ile Thr Asp Pro Val Tyr 
            980                 985                 990         


Pro Ile Gly Thr Glu Lys Glu Pro  Asn Asn Ser Lys Glu  Thr Ala Ser 
        995                 1000                 1005             


Gly Pro  Ile Val Pro Gly Ile  Pro Val Ser Gly Thr  Ile Glu Asn 
    1010                 1015                 1020             


Thr Ser  Asp Gln Asp Tyr Phe  Tyr Phe Asp Val Ile  Thr Pro Gly 
    1025                 1030                 1035             


Glu Val  Lys Ile Asp Ile Asn  Lys Leu Gly Tyr Gly  Gly Ala Thr 
    1040                 1045                 1050             


Trp Val  Val Tyr Asp Glu Asn  Asn Asn Ala Val Ser  Tyr Ala Thr 
    1055                 1060                 1065             


Asp Asp  Gly Gln Asn Leu Ser  Gly Lys Phe Lys Ala  Asp Lys Pro 
    1070                 1075                 1080             


Gly Arg  Tyr Tyr Ile His Leu  Tyr Met Phe Asn Gly  Ser Tyr Met 
    1085                 1090                 1095             


Pro Tyr  Arg Ile Asn Ile Glu  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1100                 1105                 1110             


Leu Glu  Val Leu Phe Gln Gly  Pro Gly Gly Gly Ser  Leu Ala Glu 
    1115                 1120                 1125             


Ala Lys  Val Leu Ala Asn Arg  Glu Leu Asp Lys Tyr  Gly Val Ser 
    1130                 1135                 1140             


Asp Phe  Tyr Lys Arg Leu Ile  Asn Lys Ala Lys Thr  Val Glu Gly 
    1145                 1150                 1155             


Val Glu  Ala Leu Lys Leu His  Ile Leu Ala Ala Leu  Pro His His 
    1160                 1165                 1170             


His His  His His 
    1175         


