                         SEQUENCE LISTING

<110>  Montefiore Medical Center
       Braunschweig, Ira
 
<120>  CD25 chimeric antigen receptors and uses thereof

<130>  133421-8003.WO00

<150>  US 62/893,039
<151>  2019-08-28

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  4
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu 
1               5                   10                  15      


Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly 
            20                  25                  30          


Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe 
        35                  40                  45              


Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp 
    50                  55                  60                  


Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr 
65                  70                  75                  80  


Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala 
                85                  90                  95      


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
            100                 105                 110         


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        115                 120                 125             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    130                 135                 140                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
145                 150                 155                 160 


Asp 
    


<210>  5
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val 
1               5                   10                  15      


Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr 
            20                  25                  30          


Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe 
        35                  40                  45              


Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val 
    50                  55                  60                  


Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met 
                85                  90                  95      


Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser 
            100                 105                 110         


Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr 
        115                 120                 125             


Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly 
    130                 135                 140                 


Pro Leu Cys Ser Pro 
145                 


<210>  6
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn 
1               5                   10                  15      


Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu 
            20                  25                  30          


Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys 
        35                  40                  45              


Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr 
    50                  55                  60                  


Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile 
                85                  90                  95      


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
            100                 105                 110         


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
        115                 120                 125             


Pro Gly Pro Ser Lys Pro 
    130                 


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  8
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  9
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  11
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  11

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  12
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  12

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  13
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  13

Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser 
1               5                   10                  15      


Leu Gly Val Ala Ile 
            20      


<210>  14
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  15
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  16
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  17
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  18
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  19
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  20
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (CD8H)-(CD8TM)


<220>
<221>  MISC_FEATURE
<222>  (1)..(45)
<223>  CD8H

<220>
<221>  MISC_FEATURE
<222>  (46)..(69)
<223>  CD8TM

<400>  20

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  21
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  22
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD25-CAR 4


<220>
<221>  MISC_FEATURE
<222>  (1)..(153)
<223>  IL-2 receptor ligand

<220>
<221>  MISC_FEATURE
<222>  (154)..(198)
<223>  CD8h

<220>
<221>  MISC_FEATURE
<222>  (199)..(222)
<223>  CD8a TMD

<220>
<221>  MISC_FEATURE
<222>  (223)..(263)
<223>  CD28CD

<220>
<221>  MISC_FEATURE
<222>  (264)..(305)
<223>  4-1BB/CD137CD

<220>
<221>  MISC_FEATURE
<222>  (305)..(417)
<223>  CD3zeta

<400>  22

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Thr Thr Thr Pro Ala Pro Arg 
145                 150                 155                 160 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
                165                 170                 175     


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
            180                 185                 190         


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
        195                 200                 205             


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser 
    210                 215                 220                 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
225                 230                 235                 240 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
                245                 250                 255     


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            260                 265                 270         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        275                 280                 285             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    290                 295                 300                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
305                 310                 315                 320 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                325                 330                 335     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            340                 345                 350         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        355                 360                 365             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    370                 375                 380                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
385                 390                 395                 400 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                405                 410                 415     


Arg 
    


<210>  23
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD25-CAR 4


<220>
<221>  misc_feature
<222>  (1)..(459)
<223>  IL-2 receptor ligand

<220>
<221>  misc_feature
<222>  (460)..(594)
<223>  CD8H

<220>
<221>  misc_feature
<222>  (595)..(666)
<223>  CD8aTMD

<220>
<221>  misc_feature
<222>  (667)..(789)
<223>  CD28CD

<220>
<221>  misc_feature
<222>  (790)..(915)
<223>  4-1BB/CD137CD

<220>
<221>  misc_feature
<222>  (916)..(1251)
<223>  CD3zeta

<400>  23
atgtaccgga tgcagctgct gagctgtatc gccctgtctc tggccctggt cacaaatagc       60

gcccctacca gcagcagcac caagaaaaca cagctgcaac tggaacacct cctgctggac      120

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      180

accttcaagt tctacatgcc caagaaggcc accgagctga agcacctcca gtgcctggaa      240

gaggaactga agcccctgga agaagtgctg aatctggccc agagcaagaa cttccacctg      300

aggcctaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa aggcagcgag      360

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      420

tggatcacct tctgccagag catcatcagc accctgacca ccacgacgcc agcgccgcga      480

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaagcgtgc      540

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      600

atttgggccc ctctggctgg tacttgcggg gtcctgctgc tttcactcgt gatcactctt      660

tactgtagga gcaagcggag cagactgctg cacagcgact acatgaacat gaccccccgg      720

aggcctggcc ccacccggaa gcactaccag ccctacgccc ctcccaggga tttcgccgcc      780

taccggagca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga      840

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa      900

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag      960

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1020

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1080

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1140

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1200

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              1251


<210>  24
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD25-CAR4 expression cassette


<220>
<221>  misc_feature
<222>  (13)..(471)
<223>  IL-2 receptor ligand

<220>
<221>  misc_feature
<222>  (472)..(606)
<223>  CD8H

<220>
<221>  misc_feature
<222>  (607)..(678)
<223>  CD8aTMD

<220>
<221>  misc_feature
<222>  (679)..(801)
<223>  CD28CD

<220>
<221>  misc_feature
<222>  (802)..(926)
<223>  4-1BB/CD137CD

<220>
<221>  misc_feature
<222>  (927)..(1263)
<223>  CD3zeta

<400>  24
ctcgaggcca ccatgtaccg gatgcagctg ctgagctgta tcgccctgtc tctggccctg       60

gtcacaaata gcgcccctac cagcagcagc accaagaaaa cacagctgca actggaacac      120

ctcctgctgg acctgcagat gatcctgaac ggcatcaaca actacaagaa ccccaagctg      180

acccggatgc tgaccttcaa gttctacatg cccaagaagg ccaccgagct gaagcacctc      240

cagtgcctgg aagaggaact gaagcccctg gaagaagtgc tgaatctggc ccagagcaag      300

aacttccacc tgaggcctag ggacctgatc agcaacatca acgtgatcgt gctggaactg      360

aaaggcagcg agacaacctt catgtgcgag tacgccgacg agacagctac catcgtggaa      420

tttctgaacc ggtggatcac cttctgccag agcatcatca gcaccctgac caccacgacg      480

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      540

ccagaagcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      600

tgtgatatct acatttgggc ccctctggct ggtacttgcg gggtcctgct gctttcactc      660

gtgatcactc tttactgtag gagcaagcgg agcagactgc tgcacagcga ctacatgaac      720

atgacccccc ggaggcctgg ccccacccgg aagcactacc agccctacgc ccctcccagg      780

gatttcgccg cctaccggag caaacggggc agaaagaaac tcctgtatat attcaaacaa      840

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca      900

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc      960

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1020

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1080

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1140

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1200

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1260

cgctaa                                                                1266


<210>  25
<211>  2604
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD25-CAR4 expression cassette with EF1alpha promoter


<220>
<221>  misc_feature
<222>  (1)..(1335)
<223>  EF1alpha promoter

<220>
<221>  misc_feature
<222>  (1351)..(1809)
<223>  IL-2 receptor ligand

<220>
<221>  misc_feature
<222>  (1810)..(1944)
<223>  CD8H

<220>
<221>  misc_feature
<222>  (1945)..(2016)
<223>  CD8aTMD

<220>
<221>  misc_feature
<222>  (2017)..(2139)
<223>  CD28CD

<220>
<221>  misc_feature
<222>  (2140)..(2264)
<223>  4-1BB/CD137CD

<220>
<221>  misc_feature
<222>  (2265)..(2601)
<223>  CD3zeta

<400>  25
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtgattcga attcgccacc atgtaccgga tgcagctgct gagctgtatc     1380

gccctgtctc tggccctggt cacaaatagc gcccctacca gcagcagcac caagaaaaca     1440

cagctgcaac tggaacacct cctgctggac ctgcagatga tcctgaacgg catcaacaac     1500

tacaagaacc ccaagctgac ccggatgctg accttcaagt tctacatgcc caagaaggcc     1560

accgagctga agcacctcca gtgcctggaa gaggaactga agcccctgga agaagtgctg     1620

aatctggccc agagcaagaa cttccacctg aggcctaggg acctgatcag caacatcaac     1680

gtgatcgtgc tggaactgaa aggcagcgag acaaccttca tgtgcgagta cgccgacgag     1740

acagctacca tcgtggaatt tctgaaccgg tggatcacct tctgccagag catcatcagc     1800

accctgacca ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg     1860

cagcccctgt ccctgcgccc agaagcgtgc cggccagcgg cggggggcgc agtgcacacg     1920

agggggctgg acttcgcctg tgatatctac atttgggccc ctctggctgg tacttgcggg     1980

gtcctgctgc tttcactcgt gatcactctt tactgtagga gcaagcggag cagactgctg     2040

cacagcgact acatgaacat gaccccccgg aggcctggcc ccacccggaa gcactaccag     2100

ccctacgccc ctcccaggga tttcgccgcc taccggagca aacggggcag aaagaaactc     2160

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     2220

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     2280

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     2340

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     2400

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     2460

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     2520

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     2580

atgcaggccc tgccccctcg ctaa                                            2604


