                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Wu, Catherine
       Parry, Erin
 
<120>  IMMUNE SIGNATURES PREDICTIVE OF RESPONSE TO PD-1 BLOCKADE IN 
       RICHTER'S TRANSFORMATION

<130>  52095-6340001WO

<140>  Not Yet Assigned
<141>  2020-08-27

<150>  62/893,987
<151>  2019-08-28

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu 
    210                 215                 220                 


Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys 
225                 230                 235                 240 


Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met 
                245                 250                 255     


Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser 
            260                 265                 270         


Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285         


<210>  2
<211>  2111
<212>  DNA
<213>  Homo sapiens

<400>  2
acagtttccc ttccgctcac ctccgcctga gcagtggaga aggcggcact ctggtggggc       60

tgctccaggc atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact      120

gggctggcgg ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt      180

ctccccagcc ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc      240

caacacatcg gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga      300

caagctggcc gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt      360

cacacaactg cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga      420

cagcggcacc tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag      480

cctgcgggca gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag      540

cccctcaccc aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct      600

gctgggcagc ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg      660

agggacaata ggagccaggc gcaccggcca gcccctggag gacccctcag ccgtgcctgt      720

gttctctgtg gactatgggg agctggattt ccagtggcga gagaagaccc cggagccccc      780

cgtgccctgt gtccctgagc agacggagta tgccaccatt gtctttccta gcggaatggg      840

cacctcatcc cccgcccgca ggggctcagc tgacggccct cggagtgccc agccactgag      900

gcctgaggat ggacactgct cttggcccct ctgaccggct tccttggcca ccagtgttct      960

gcagaccctc caccatgagc ccgggtcagc gcatttcctc aggagaagca ggcagggtgc     1020

aggccattgc aggccgtcca ggggctgagc tgcctggggg cgaccggggc tccagcctgc     1080

acctgcacca ggcacagccc caccacagga ctcatgtctc aatgcccaca gtgagcccag     1140

gcagcaggtg tcaccgtccc ctacagggag ggccagatgc agtcactgct tcaggtcctg     1200

ccagcacaga gctgcctgcg tccagctccc tgaatctctg ctgctgctgc tgctgctgct     1260

gctgctgcct gcggcccggg gctgaaggcg ccgtggccct gcctgacgcc ccggagcctc     1320

ctgcctgaac ttgggggctg gttggagatg gccttggagc agccaaggtg cccctggcag     1380

tggcatcccg aaacgccctg gacgcagggc ccaagactgg gcacaggagt gggaggtaca     1440

tggggctggg gactccccag gagttatctg ctccctgcag gcctagagaa gtttcaggga     1500

aggtcagaag agctcctggc tgtggtgggc agggcaggaa acccctccac ctttacacat     1560

gcccaggcag cacctcaggc cctttgtggg gcagggaagc tgaggcagta agcgggcagg     1620

cagagctgga ggcctttcag gcccagccag cactctggcc tcctgccgcc gcattccacc     1680

ccagcccctc acaccactcg ggagagggac atcctacggt cccaaggtca ggagggcagg     1740

gctggggttg actcaggccc ctcccagctg tggccacctg ggtgttggga gggcagaagt     1800

gcaggcacct agggcccccc atgtgcccac cctgggagct ctccttggaa cccattcctg     1860

aaattattta aaggggttgg ccgggctccc accagggcct gggtgggaag gtacaggcgt     1920

tcccccgggg cctagtaccc ccgccgtggc ctatccactc ctcacatcca cacactgcac     1980

ccccactcct ggggcagggc caccagcatc caggcggcca gcaggcacct gagtggctgg     2040

gacaagggat cccccttccc tgtggttcta ttatattata attataatta aatatgagag     2100

catgctaagg a                                                          2111


<210>  3
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Lys Glu Glu Ser Ala Ala Gln Leu Gly Cys Cys His Arg Pro Met 
1               5                   10                  15      


Ala Leu Gly Gly Thr Gly Gly Ser Leu Ser Pro Ser Leu Asp Phe Gln 
            20                  25                  30          


Leu Phe Arg Gly Asp Gln Val Phe Ser Ala Cys Arg Pro Leu Pro Asp 
        35                  40                  45              


Met Val Asp Ala His Gly Pro Ser Cys Ala Ser Trp Leu Cys Pro Leu 
    50                  55                  60                  


Pro Leu Ala Pro Gly Arg Ser Ala Leu Leu Ala Cys Leu Gln Asp Leu 
65                  70                  75                  80  


Asp Leu Asn Leu Cys Thr Pro Gln Pro Ala Pro Leu Gly Thr Asp Leu 
                85                  90                  95      


Gln Gly Leu Gln Glu Asp Ala Leu Ser Met Lys His Glu Pro Pro Gly 
            100                 105                 110         


Leu Gln Ala Ser Ser Thr Asp Asp Lys Lys Phe Thr Val Lys Tyr Pro 
        115                 120                 125             


Gln Asn Lys Asp Lys Leu Gly Lys Gln Pro Glu Arg Ala Gly Glu Gly 
    130                 135                 140                 


Ala Pro Cys Pro Ala Phe Ser Ser His Asn Ser Ser Ser Pro Pro Pro 
145                 150                 155                 160 


Leu Gln Asn Arg Lys Ser Pro Ser Pro Leu Ala Phe Cys Pro Cys Pro 
                165                 170                 175     


Pro Val Asn Ser Ile Ser Lys Glu Leu Pro Phe Leu Leu His Ala Phe 
            180                 185                 190         


Tyr Pro Gly Tyr Pro Leu Leu Leu Pro Pro Pro His Leu Phe Thr Tyr 
        195                 200                 205             


Gly Ala Leu Pro Ser Asp Gln Cys Pro His Leu Leu Met Leu Pro Gln 
    210                 215                 220                 


Asp Pro Ser Tyr Pro Thr Met Ala Met Pro Ser Leu Leu Met Met Val 
225                 230                 235                 240 


Asn Glu Leu Gly His Pro Ser Ala Arg Trp Glu Thr Leu Leu Pro Tyr 
                245                 250                 255     


Pro Gly Ala Phe Gln Ala Ser Gly Gln Ala Leu Pro Ser Gln Ala Arg 
            260                 265                 270         


Asn Pro Gly Ala Gly Ala Ala Pro Thr Asp Ser Pro Gly Leu Glu Arg 
        275                 280                 285             


Gly Gly Met Ala Ser Pro Ala Lys Arg Val Pro Leu Ser Ser Gln Thr 
    290                 295                 300                 


Gly Thr Ala Ala Leu Pro Tyr Pro Leu Lys Lys Lys Asn Gly Lys Ile 
305                 310                 315                 320 


Leu Tyr Glu Cys Asn Ile Cys Gly Lys Ser Phe Gly Gln Leu Ser Asn 
                325                 330                 335     


Leu Lys Val His Leu Arg Val His Ser Gly Glu Arg Pro Phe Gln Cys 
            340                 345                 350         


Ala Leu Cys Gln Lys Ser Phe Thr Gln Leu Ala His Leu Gln Lys His 
        355                 360                 365             


His Leu Val His Thr Gly Glu Arg Pro His Lys Cys Ser Val Cys His 
    370                 375                 380                 


Lys Arg Phe Ser Ser Ser Ser Asn Leu Lys Thr His Leu Arg Leu His 
385                 390                 395                 400 


Ser Gly Ala Arg Pro Phe Gln Cys Ser Val Cys Arg Ser Arg Phe Thr 
                405                 410                 415     


Gln His Ile His Leu Lys Leu His His Arg Leu His Ala Pro Gln Pro 
            420                 425                 430         


Cys Gly Leu Val His Thr Gln Leu Pro Leu Ala Ser Leu Ala Cys Leu 
        435                 440                 445             


Ala Gln Trp His Gln Gly Ala Leu Asp Leu Met Ala Val Ala Ser Glu 
    450                 455                 460                 


Lys His Met Gly Tyr Asp Ile Asp Glu Val Lys Val Ser Ser Thr Ser 
465                 470                 475                 480 


Gln Gly Lys Ala Arg Ala Val Ser Leu Ser Ser Ala Gly Thr Pro Leu 
                485                 490                 495     


Val Met Gly Gln Asp Gln Asn Asn 
            500                 


<210>  4
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  4
actttgtccc acatgccctg gggaggtagc acaaagggag gaccatggtc ttctaactga       60

ggaacctgag cagatgcctt gacccagacc agagacccaa gccaaggaaa gcccatgatc      120

accagacagg taatggggat atgaaggaag aatcagctgc acaattaggt tgttgtcata      180

ggcccatggc cctgggaggt acagggggct ccctgtcccc cagcctggac ttccagctct      240

tccgaggtga ccaggtcttc tcagcctgca gaccacttcc agacatggtg gatgctcatg      300

gcccatcctg tgccagctgg ctgtgtccct tgcccctggc accgggcagg tctgcactgc      360

tggcctgcct acaggacctg gacctgaacc tgtgcacccc acagccggca cccctgggca      420

cagacctgca gggcctccaa gaggacgcct tgagcatgaa gcacgagcca ccagggctgc      480

aggccagctc caccgatgac aagaaattca cagtcaagta cccacagaac aaggacaagc      540

tgggaaaaca gccagaaaga gctggcgagg gggccccctg cccagccttc tcctctcata      600

acagctcttc cccaccaccg ctgcagaaca gaaagagccc cagccccttg gctttctgcc      660

cctgtccccc tgtcaactcc atctccaagg agctcccatt tctcctccac gccttctacc      720

ctggataccc acttctcctg cctccacccc acctgttcac ctatggggcc ctaccttctg      780

accaatgtcc ccacctcctc atgctgcccc aagacccctc ctaccccacc atggctatgc      840

ctagcctgct gatgatggtc aatgagctgg ggcaccccag cgctcggtgg gagaccctgc      900

ttccctaccc aggggccttc caagcctctg gccaagctct gccttcccag gcccgaaatc      960

caggtgctgg agctgcccca accgactccc caggcctgga gcgtggtggc atggcatctc     1020

cagcaaagcg ggtcccattg agttcccaga caggcaccgc agccttgcct tacccgctga     1080

aaaagaagaa tggcaaaatc ctgtacgagt gcaacatatg tggcaagagc tttgggcagc     1140

tctccaatct caaggtccac ctgcgtgtgc acagtggaga gcgtccattc cagtgtgcct     1200

tgtgccagaa gagcttcact caacttgccc acctgcagaa gcaccacctg gtgcacactg     1260

gggagcggcc ccacaagtgc tcggtgtgcc acaagcgctt cagcagctcc agtaacctca     1320

agacccacct gcgcctgcac tccggggccc ggcccttcca gtgcagtgtc tgccggagtc     1380

gcttcaccca gcacatccac ctgaagctgc accatcggct gcatgcccca cagccctgtg     1440

gcctggtgca cacccagctg cccctggcct ctctggcctg ccttgcccaa tggcaccagg     1500

gggcactaga tcttatggcg gtggcatctg agaaacacat gggctatgac atagatgagg     1560

tcaaagtgtc ctcgacatcc caggggaaag caagagcagt gagcctgagc agtgccggga     1620

ctcccctggt gatggggcag gaccagaaca attaaaaatg tttcttctgt caaaaaaaaa     1680

aaaaaaa                                                               1687


<210>  5
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Glu Glu Ser Ala Ala Gln Leu Gly Cys Cys His Arg Pro Met 
1               5                   10                  15      


Ala Leu Gly Gly Thr Gly Gly Ser Leu Ser Pro Ser Leu Asp Phe Gln 
            20                  25                  30          


Leu Phe Arg Gly Asp Gln Val Phe Ser Ala Cys Arg Pro Leu Pro Asp 
        35                  40                  45              


Met Val Asp Ala His Gly Pro Ser Cys Ala Ser Trp Leu Cys Pro Leu 
    50                  55                  60                  


Pro Leu Ala Pro Gly Arg Ser Ala Leu Leu Ala Cys Leu Gln Asp Leu 
65                  70                  75                  80  


Asp Leu Asn Leu Cys Thr Pro Gln Pro Ala Pro Leu Gly Thr Asp Leu 
                85                  90                  95      


Gln Gly Leu Gln Glu Asp Ala Leu Ser Met Lys His Glu Pro Pro Gly 
            100                 105                 110         


Leu Gln Ala Ser Ser Thr Asp Asp Lys Lys Phe Thr Val Lys Tyr Pro 
        115                 120                 125             


Gln Asn Lys Asp Lys Leu Gly Lys Gln Pro Glu Arg Ala Gly Glu Gly 
    130                 135                 140                 


Ala Pro Cys Pro Ala Phe Ser Ser His Asn Ser Ser Ser Pro Pro Pro 
145                 150                 155                 160 


Leu Gln Asn Arg Lys Ser Pro Ser Pro Leu Ala Phe Cys Pro Cys Pro 
                165                 170                 175     


Pro Val Asn Ser Ile Ser Lys Glu Leu Pro Phe Leu Leu His Ala Phe 
            180                 185                 190         


Tyr Pro Gly Tyr Pro Leu Leu Leu Pro Pro Pro His Leu Phe Thr Tyr 
        195                 200                 205             


Gly Ala Leu Pro Ser Asp Gln Cys Pro His Leu Leu Met Leu Pro Gln 
    210                 215                 220                 


Asp Pro Ser Tyr Pro Thr Met Ala Met Pro Ser Leu Leu Met Met Val 
225                 230                 235                 240 


Asn Glu Leu Gly His Pro Ser Ala Arg Trp Glu Thr Leu Leu Pro Tyr 
                245                 250                 255     


Pro Gly Ala Phe Gln Ala Ser Gly Gln Ala Leu Pro Ser Gln Ala Arg 
            260                 265                 270         


Asn Pro Gly Ala Gly Ala Ala Pro Thr Asp Ser Pro Gly Leu Glu Arg 
        275                 280                 285             


Gly Gly Met Ala Ser Pro Ala Lys Arg Val Pro Leu Ser Ser Gln Thr 
    290                 295                 300                 


Gly Thr Ala Ala Leu Pro Tyr Pro Leu Lys Lys Lys Asn Gly Lys Ile 
305                 310                 315                 320 


Leu Tyr Glu Cys Asn Ile Cys Gly Lys Ser Phe Gly Gln Leu Ser Asn 
                325                 330                 335     


Leu Lys Val His Leu Arg Val His Ser Gly Glu Arg Pro Phe Gln Cys 
            340                 345                 350         


Ala Leu Cys Gln Lys Ser Phe Thr Gln Leu Ala His Leu Gln Lys His 
        355                 360                 365             


His Leu Val His Thr Gly Glu Arg Pro His Lys Cys Ser Val Cys His 
    370                 375                 380                 


Lys Arg Phe Ser Ser Ser Ser Asn Leu Lys Thr His Leu Arg Leu His 
385                 390                 395                 400 


Ser Gly Ala Arg Pro Phe Gln Cys Ser Val Cys Arg Ser Arg Phe Thr 
                405                 410                 415     


Gln His Ile His Leu Lys Leu His His Arg Leu His Ala Pro Gln Pro 
            420                 425                 430         


Cys Gly Leu Val His Thr Gln Leu Pro Leu Ala Ser Leu Ala Cys Leu 
        435                 440                 445             


Ala Gln Trp His Gln Gly Ala Leu Asp Leu Met Ala Val Ala Ser Glu 
    450                 455                 460                 


Lys His Met Gly Tyr Asp Ile Asp Glu Val Lys Val Ser Ser Thr Ser 
465                 470                 475                 480 


Gln Gly Lys Ala Arg Ala Val Ser Leu Ser Ser Ala Gly Thr Pro Leu 
                485                 490                 495     


Val Met Gly Gln Asp Gln Asn Asn 
            500                 


<210>  6
<211>  4076
<212>  DNA
<213>  Homo sapiens

<400>  6
ctcttcttct taaacaaacc acaaacggat gtgagggaag gaaggtgttt cttttactcc       60

tgagcccaga cacctcactc tgttccgtct aagcttgttt tgctgaacac ttttttttaa      120

aaaaggaaaa agaaaaggag ttgcttgatg tgagagtgaa atggacgtaa gattttatcc      180

acctccagcc cagcccgccg ctgcgcccga cgctccctgt ctgggacctt ctccctgcct      240

ggacccctac tattgcaaca agtttgacgg tgagaacatg tatatgagca tgacagagcc      300

gagccaggac tatgtgccag ccagccagtc ctaccctggt ccaagcctgg aaagtgaaga      360

cttcaacatt ccaccaatta ctcctccttc cctcccagac cactcgctgg tgcacctgaa      420

tgaagttgag tctggttacc attctctgtg tcaccccatg aaccataatg gcctgctacc      480

atttcatcca caaaacatgg acctccctga aatcacagtc tccaatatgc tgggccagga      540

tggaacactg ctttctaatt ccatttctgt gatgccagat atacgaaacc cagaaggaac      600

tcagtacagt tcccatcctc agatggcagc catgagacca aggggccagc ctgcagacat      660

caggcagcag ccaggaatga tgccacatgg ccagctgact accattaacc agtcacagct      720

aagtgctcaa cttggtttga atatgggagg aagcaatgtt ccccacaact caccatctcc      780

acctggaagc aagtctgcaa ctccttcacc atccagttca gtgcatgaag atgaaggcga      840

tgatacctct aagatcaatg gtggagagaa gcggcctgcc tctgatatgg ggaaaaaacc      900

aaaaactccc aaaaagaaga agaagaagga tcccaatgag ccccagaagc ctgtgtctgc      960

ctatgcgtta ttctttcgtg atactcaggc cgccatcaag ggccaaaatc caaacgctac     1020

ctttggcgaa gtctctaaaa ttgtggcttc aatgtgggac ggtttaggag aagagcaaaa     1080

acaggtctat aaaaagaaaa ccgaggctgc gaagaaggag tacctgaagc aactcgcagc     1140

atacagagcc agccttgtat ccaagagcta cagtgaacct gttgacgtga agacatctca     1200

acctcctcag ctgatcaatt cgaagccgtc ggtgttccat gggcccagcc aggcccactc     1260

ggccctgtac ctaagttccc actatcacca acaaccggga atgaatcctc acctaactgc     1320

catgcatcct agtctcccca ggaacatagc ccccaagccg aataaccaaa tgccagtgac     1380

tgtctctata gcaaacatgg ctgtgtcccc tcctcctccc ctccagatca gcccgcctct     1440

tcaccagcat ctcaacatgc agcagcacca gccgctcacc atgcagcagc cccttgggaa     1500

ccagctcccc atgcaggtcc agtctgcctt acactcaccc accatgcagc aaggatttac     1560

tcttcaaccc gactatcaga ctattatcaa tcctacatct acagctgcac aagttgtcac     1620

ccaggcaatg gagtatgtgc gttcggggtg cagaaatcct cccccacaac cggtggactg     1680

gaataacgac tactgcagta gtgggggcat gcagagggac aaagcactgt accttacttg     1740

agaatctgaa cacctcttct ttccactgag gaattcaggg aagtgttttc accatggatt     1800

gctttgtaca gtcaaggcag ttctccattt tattagaaaa tacaagttgc taagcactta     1860

ggaccatttg agcttgtggg tcacccactc tggaagaaat agtcatgctt ctttattatt     1920

tttttaatcc tttatggaca ttgtttttct tcttccctga aggaaatttg gaccattcag     1980

attttatgtt ggttttttgc tgtgaagtgc tgcgctctag taactgcctt agcaactgta     2040

gatgtctcgg ataaaagtcc tggattttcc attggttttc ataatgggtg tttatatgaa     2100

actactaaag actttttaaa tggcttgatg tagcagtcat agcaagtttg taaatagcat     2160

ctatgttaca ctctcctaga gtataaaatg tgaatgtttt tgtagctaaa ttgtaattga     2220

aactggctca ttccagttta ttgatttcac aataggggtt aaattggcaa acattcatat     2280

ttttacttca tttttaaaac aactgactga tagttctata ttttcaaaat atttgaaaat     2340

aaaaagtatt cccaagtgat tttaatttaa aaacaaattg gctttgtctc attgatcaga     2400

caaaaagaaa ctagtattaa gggaagcgca aacacattta ttttgtactg cagaaaaatt     2460

gcttttttgt atcacttttt gtgtaatggt tagtaaatgt catttaagtc cttttatgta     2520

taaaactgcc aaatgcttac ctggtatttt attagatgca gaaacagatt ggaaacagct     2580

aaattacaac ttttacatat ggctctgtct tattgtttct tcatactgtg tctgtattta     2640

atcttttttt atggaacctg ttgcgcctat ttatgaaata ataaatatag gtgtttgtaa     2700

gtaaatttgt tagtatttga aagaggtttc tttgatgttt taacttttgc tggcaaaaaa     2760

aaattcacgc ttggtgtgaa tactttatta tttagttttt acagtaacat gaataaagcc     2820

aaacctgctt ttcatttagc agcaaattaa agtaaccagt ccttatttct gcatttcttt     2880

ggttgatgca aacaaaaaac tattatattt aagaacttta tttcttcata cgacataaca     2940

gaattgccct ccaagtcaca caagctccaa gactaaacaa acagacaggt cctctgtctt     3000

aaaaaggtta cttcttggtt ctcagctggt tctagtcaat tctgaaccac caccccccgc     3060

cccccgcaaa aaagtaaaag tcaaaccaaa cttcctcaag ctgcatgctt ttcacaaaat     3120

ccagaaagca tttaagaatt gaactagggg ctggaagaag tgaaagggaa gcatctaaaa     3180

atgaaaggtg agtaaccaga tagcaaaaga aaagggaaag ccatccaaat ttgaaagctg     3240

ttgatagaaa ttgagattct tgctgtcttt tgtgcctcta caagctacta ctcattccag     3300

aattcctggg tcttccaaga ggattcttaa ggtaccagag atttgctagg gaaccaaaag     3360

tgcttgagaa tctgcctgag ggcttgcata gctttcacat taaaaaaaga aaaagctagc     3420

agatttactc ctttttaggg gatcatatca agaaagttag tctggttgga aaccaagaga     3480

atggctgatg tctctttctt ggaatatgtg aaataaattt agcagtttaa ctaaatacaa     3540

atatatgcat tgtgtaatcc actcagaatt aaacagacaa aaggtatgct tgctttggaa     3600

tgattttagg cattgtacaa ccttgaatca cttgagcatg taataactaa taaataatgc     3660

agatccatgt gattattaaa atgactgtag ctgagagctc taattttcct gtcttgaaac     3720

tgtataagaa ctcatgtgat taagttcaca gtttattgtt tgtctgttta gtattttaga     3780

aatataccag cactactaat taactaatgt cttttattta ttatattatg ataaagtaaa     3840

aatttcactt gcattaagtc taaactgaga aggtaattac tgggaggaga atgagcagct     3900

ttgactttga caggcggttt gtgcaggaaa gcacagtgcc gtgttgttta cagcttttct     3960

agagcagctg tgcgaccagg gtagagagtg ttgaaattca ataccaaata cagtaaaaac     4020

aaatgtaaat aaaagaaaac acatcatcaa taaaactgtt attatgcgtg accgta         4076


