                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
 
<120>  SUBSTITUTED PYRIDOPYRIMIDINONYL COMPOUNDS USEFUL AS T CELL 
       ACTIVATORS

<130>  13255-WO-PCT

<150>  US 62/892,799
<151>  2019-08-28

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  1
atggccaagg agaggggcct aataagcccc agtgattttg cccagctgca aaaatacatg       60

gaatactcca ccaaaaaggt cagtgatgtc ctaaagctct tcgaggatgg cgagatggct      120

aaatatgtcc aaggagatgc cattgggtac gagggattcc agcaattcct gaaaatctat      180

ctcgaagtgg ataatgttcc cagacaccta agcctggcac tgtttcaatc ctttgagact      240

ggtcactgct taaatgagac aaatgtgaca aaagatgtgg tgtgtctcaa tgatgtttcc      300

tgctactttt cccttctgga gggtggtcgg ccagaagaca agttagaatt caccttcaag      360

ctgtacgaca cggacagaaa tgggatcctg gacagctcag aagtggacaa aattatccta      420

cagatgatgc gagtggctga atacctggat tgggatgtgt ctgagctgag gccgattctt      480

caggagatga tgaaagagat tgactatgat ggcagtggct ctgtctctca agctgagtgg      540

gtccgggctg gggccaccac cgtgccactg ctagtgctgc tgggtctgga gatgactctg      600

aaggacgacg gacagcacat gtggaggccc aagaggttcc ccagaccagt ctactgcaat      660

ctgtgcgagt caagcattgg tcttggcaaa cagggactga gctgtaacct ctgtaagtac      720

actgttcacg accagtgtgc catgaaagcc ctgccttgtg aagtcagcac ctatgccaag      780

tctcggaagg acattggtgt ccaatcacat gtgtgggtgc gaggaggctg tgagtccggg      840

cgctgcgacc gctgtcagaa aaagatccgg atctaccaca gtctgaccgg gctgcattgt      900

gtatggtgcc acctagagat ccacgatgac tgcctgcaag cggtgggcca tgagtgtgac      960

tgtgggctgc tccgggatca catcctgcct ccatcttcca tctatcccag tgtcctggcc     1020

tctggaccgg atcgtaaaaa tagcaaaaca agccagaaga ccatggatga tttaaatttg     1080

agcacctctg aggctctgcg gattgaccct gttcctaaca cccacccact tctcgtcttt     1140

gtcaatccta agagtggcgg gaagcagggg cagagggtgc tctggaagtt ccagtatata     1200

ttaaaccctc gacaggtgtt caacctccta aaggatggtc ctgagatagg gctccgatta     1260

ttcaaggatg ttcctgatag ccggattttg gtgtgtggtg gagacggcac agtaggctgg     1320

attctagaga ccattgacaa agctaacttg ccagttttgc ctcctgttgc tgtgttgccc     1380

ctgggtactg gaaatgatct ggctcgatgc ctaagatggg gaggaggtta tgaaggacag     1440

aatctggcaa agatcctcaa ggatttagag atgagtaaag tggtacatat ggatcgatgg     1500

tctgtggagg tgatacctca acaaactgaa gaaaaaagtg acccagtccc ctttcaaatc     1560

atcaataact acttctctat tggcgtggat gcctctattg ctcatcgatt ccacatcatg     1620

cgagagaaat atccggagaa gttcaacagc agaatgaaga acaagctatg gtacttcgaa     1680

tttgccacat ctgaatccat cttctcaaca tgcaaaaagc tggaggagtc tttgacagtt     1740

gagatctgtg ggaaaccgct ggatctgagc aacctgtccc tagaaggcat cgcagtgcta     1800

aacatcccta gcatgcatgg tggctccaac ctctggggtg ataccaggag accccatggg     1860

gatatctatg ggatcaacca ggccttaggt gctacagcta aagtcatcac cgaccctgat     1920

atcctgaaaa cctgtgtacc agacctaagt gacaagagac tggaagtggt tgggctggag     1980

ggtgcaattg agatgggcca aatctatacc aagctcaaga atgctggacg tcggctggcc     2040

aagtgctctg agatcacctt ccacaccaca aaaacccttc ccatgcaaat tgacggagaa     2100

ccctggatgc agacgccctg tacaatcaag atcacccaca agaaccagat gcccatgctc     2160

atgggcccac ccccccgctc caccaatttc tttggcttct tgagcggatc ctcggagaca     2220

gtgcggtttc agggacacca ccaccatcac cactga                               2256


<210>  2
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Pro Ser Asp Phe Ala Gln Leu Gln Lys Tyr Met Glu Tyr 
1               5                   10                  15      


Ser Thr Lys Lys Val Ser Asp Val Leu Lys Leu Phe Glu Asp Gly Glu 
            20                  25                  30          


Met Ala Lys Tyr Val Gln Gly Asp Ala Ile Gly Tyr Glu Gly Phe Gln 
        35                  40                  45              


Gln Phe Leu Lys Ile Tyr Leu Glu Val Asp Asn Val Pro Arg His Leu 
    50                  55                  60                  


Ser Leu Ala Leu Phe Gln Ser Phe Glu Thr Gly His Cys Leu Asn Glu 
65                  70                  75                  80  


Thr Asn Val Thr Lys Asp Val Val Cys Leu Asn Asp Val Ser Cys Tyr 
                85                  90                  95      


Phe Ser Leu Leu Glu Gly Gly Arg Pro Glu Asp Lys Leu Glu Phe Thr 
            100                 105                 110         


Phe Lys Leu Tyr Asp Thr Asp Arg Asn Gly Ile Leu Asp Ser Ser Glu 
        115                 120                 125             


Val Asp Lys Ile Ile Leu Gln Met Met Arg Val Ala Glu Tyr Leu Asp 
    130                 135                 140                 


Trp Asp Val Ser Glu Leu Arg Pro Ile Leu Gln Glu Met Met Lys Glu 
145                 150                 155                 160 


Ile Asp Tyr Asp Gly Ser Gly Ser Val Ser Gln Ala Glu Trp Val Arg 
                165                 170                 175     


Ala Gly Ala Thr Thr Val Pro Leu Leu Val Leu Leu Gly Leu Glu Met 
            180                 185                 190         


Thr Leu Lys Asp Asp Gly Gln His Met Trp Arg Pro Lys Arg Phe Pro 
        195                 200                 205             


Arg Pro Val Tyr Cys Asn Leu Cys Glu Ser Ser Ile Gly Leu Gly Lys 
    210                 215                 220                 


Gln Gly Leu Ser Cys Asn Leu Cys Lys Tyr Thr Val His Asp Gln Cys 
225                 230                 235                 240 


Ala Met Lys Ala Leu Pro Cys Glu Val Ser Thr Tyr Ala Lys Ser Arg 
                245                 250                 255     


Lys Asp Ile Gly Val Gln Ser His Val Trp Val Arg Gly Gly Cys Glu 
            260                 265                 270         


Ser Gly Arg Cys Asp Arg Cys Gln Lys Lys Ile Arg Ile Tyr His Ser 
        275                 280                 285             


Leu Thr Gly Leu His Cys Val Trp Cys His Leu Glu Ile His Asp Asp 
    290                 295                 300                 


Cys Leu Gln Ala Val Gly His Glu Cys Asp Cys Gly Leu Leu Arg Asp 
305                 310                 315                 320 


His Ile Leu Pro Pro Ser Ser Ile Tyr Pro Ser Val Leu Ala Ser Gly 
                325                 330                 335     


Pro Asp Arg Lys Asn Ser Lys Thr Ser Gln Lys Thr Met Asp Asp Leu 
            340                 345                 350         


Asn Leu Ser Thr Ser Glu Ala Leu Arg Ile Asp Pro Val Pro Asn Thr 
        355                 360                 365             


His Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly Gly Lys Gln Gly 
    370                 375                 380                 


Gln Arg Val Leu Trp Lys Phe Gln Tyr Ile Leu Asn Pro Arg Gln Val 
385                 390                 395                 400 


Phe Asn Leu Leu Lys Asp Gly Pro Glu Ile Gly Leu Arg Leu Phe Lys 
                405                 410                 415     


Asp Val Pro Asp Ser Arg Ile Leu Val Cys Gly Gly Asp Gly Thr Val 
            420                 425                 430         


Gly Trp Ile Leu Glu Thr Ile Asp Lys Ala Asn Leu Pro Val Leu Pro 
        435                 440                 445             


Pro Val Ala Val Leu Pro Leu Gly Thr Gly Asn Asp Leu Ala Arg Cys 
    450                 455                 460                 


Leu Arg Trp Gly Gly Gly Tyr Glu Gly Gln Asn Leu Ala Lys Ile Leu 
465                 470                 475                 480 


Lys Asp Leu Glu Met Ser Lys Val Val His Met Asp Arg Trp Ser Val 
                485                 490                 495     


Glu Val Ile Pro Gln Gln Thr Glu Glu Lys Ser Asp Pro Val Pro Phe 
            500                 505                 510         


Gln Ile Ile Asn Asn Tyr Phe Ser Ile Gly Val Asp Ala Ser Ile Ala 
        515                 520                 525             


His Arg Phe His Ile Met Arg Glu Lys Tyr Pro Glu Lys Phe Asn Ser 
    530                 535                 540                 


Arg Met Lys Asn Lys Leu Trp Tyr Phe Glu Phe Ala Thr Ser Glu Ser 
545                 550                 555                 560 


Ile Phe Ser Thr Cys Lys Lys Leu Glu Glu Ser Leu Thr Val Glu Ile 
                565                 570                 575     


Cys Gly Lys Pro Leu Asp Leu Ser Asn Leu Ser Leu Glu Gly Ile Ala 
            580                 585                 590         


Val Leu Asn Ile Pro Ser Met His Gly Gly Ser Asn Leu Trp Gly Asp 
        595                 600                 605             


Thr Arg Arg Pro His Gly Asp Ile Tyr Gly Ile Asn Gln Ala Leu Gly 
    610                 615                 620                 


Ala Thr Ala Lys Val Ile Thr Asp Pro Asp Ile Leu Lys Thr Cys Val 
625                 630                 635                 640 


Pro Asp Leu Ser Asp Lys Arg Leu Glu Val Val Gly Leu Glu Gly Ala 
                645                 650                 655     


Ile Glu Met Gly Gln Ile Tyr Thr Lys Leu Lys Asn Ala Gly Arg Arg 
            660                 665                 670         


Leu Ala Lys Cys Ser Glu Ile Thr Phe His Thr Thr Lys Thr Leu Pro 
        675                 680                 685             


Met Gln Ile Asp Gly Glu Pro Trp Met Gln Thr Pro Cys Thr Ile Lys 
    690                 695                 700                 


Ile Thr His Lys Asn Gln Met Pro Met Leu Met Gly Pro Pro Pro Arg 
705                 710                 715                 720 


Ser Gly Ser Ser Glu Thr Val Arg Phe Gln Gly His His His His His 
                725                 730                 735     


His 
    


<210>  3
<211>  2838
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Thr Gly Gly Ala Gly Cys Cys Gly Cys Gly Gly Gly Ala Cys Gly 
1               5                   10                  15      


Gly Thr Ala Gly Cys Cys Cys Cys Gly Ala Gly Gly Cys Cys Cys Gly 
            20                  25                  30          


Gly Ala Gly Cys Ala Gly Cys Gly Ala Cys Thr Cys Cys Gly Ala Gly 
        35                  40                  45              


Thr Cys Gly Gly Cys Thr Thr Cys Cys Gly Cys Cys Thr Cys Gly Thr 
    50                  55                  60                  


Cys Cys Ala Gly Cys Gly Gly Cys Thr Cys Cys Gly Ala Gly Cys Gly 
65                  70                  75                  80  


Cys Gly Ala Cys Gly Cys Cys Gly Gly Thr Cys Cys Cys Gly Ala Gly 
                85                  90                  95      


Cys Cys Gly Gly Ala Cys Ala Ala Gly Gly Cys Gly Cys Cys Gly Cys 
            100                 105                 110         


Gly Gly Cys Gly Ala Cys Thr Cys Ala Ala Cys Ala Ala Gly Cys Gly 
        115                 120                 125             


Gly Cys Gly Cys Thr Thr Cys Cys Cys Gly Gly Gly Gly Cys Thr Gly 
    130                 135                 140                 


Cys Gly Gly Cys Thr Cys Thr Thr Cys Gly Gly Gly Cys Ala Cys Ala 
145                 150                 155                 160 


Gly Gly Ala Ala Ala Gly Cys Cys Ala Thr Cys Ala Cys Gly Ala Ala 
                165                 170                 175     


Gly Thr Cys Gly Gly Gly Cys Cys Thr Cys Cys Ala Gly Cys Ala Cys 
            180                 185                 190         


Cys Thr Gly Gly Cys Cys Cys Cys Cys Cys Cys Thr Cys Cys Gly Cys 
        195                 200                 205             


Cys Cys Ala Cys Cys Cys Cys Thr Gly Gly Gly Gly Cys Cys Cys Cys 
    210                 215                 220                 


Gly Thr Gly Cys Ala Gly Cys Gly Ala Gly Thr Cys Ala Gly Ala Gly 
225                 230                 235                 240 


Cys Gly Gly Cys Ala Gly Ala Thr Cys Cys Gly Gly Ala Gly Thr Ala 
                245                 250                 255     


Cys Ala Gly Thr Gly Gly Ala Cys Thr Gly Gly Ala Gly Cys Gly Ala 
            260                 265                 270         


Gly Thr Cys Ala Gly Cys Gly Ala Cys Ala Thr Ala Thr Gly Gly Gly 
        275                 280                 285             


Gly Ala Gly Cys Ala Cys Ala Thr Cys Thr Gly Gly Thr Thr Cys Gly 
    290                 295                 300                 


Ala Gly Ala Cys Cys Ala Ala Cys Gly Thr Gly Thr Cys Cys Gly Gly 
305                 310                 315                 320 


Gly Gly Ala Cys Thr Thr Cys Thr Gly Cys Thr Ala Cys Gly Thr Thr 
                325                 330                 335     


Gly Gly Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Thr Gly Thr Gly 
            340                 345                 350         


Thr Ala Gly Cys Cys Ala Gly Gly Ala Thr Gly Cys Thr Gly Cys Ala 
        355                 360                 365             


Gly Ala Ala Gly Thr Cys Ala Gly Thr Gly Thr Cys Thr Cys Gly Ala 
    370                 375                 380                 


Ala Gly Ala Ala Ala Gly Thr Gly Cys Gly Cys Ala Gly Cys Cys Thr 
385                 390                 395                 400 


Gly Cys Ala Ala Gly Ala Thr Thr Gly Thr Gly Gly Thr Gly Cys Ala 
                405                 410                 415     


Cys Ala Cys Gly Cys Cys Cys Thr Gly Cys Ala Thr Cys Gly Ala Gly 
            420                 425                 430         


Cys Ala Gly Cys Thr Gly Gly Ala Gly Ala Ala Gly Ala Thr Ala Ala 
        435                 440                 445             


Ala Thr Thr Thr Cys Cys Gly Cys Thr Gly Thr Ala Ala Gly Cys Cys 
    450                 455                 460                 


Gly Thr Cys Cys Thr Thr Cys Cys Gly Thr Gly Ala Ala Thr Cys Ala 
465                 470                 475                 480 


Gly Gly Cys Thr Cys Cys Ala Gly Gly Ala Ala Thr Gly Thr Cys Cys 
                485                 490                 495     


Gly Cys Gly Ala Gly Cys Cys Ala Ala Cys Cys Thr Thr Thr Gly Thr 
            500                 505                 510         


Ala Cys Gly Gly Cys Ala Cys Cys Ala Cys Thr Gly Gly Gly Thr Ala 
        515                 520                 525             


Cys Ala Cys Ala Gly Ala Cys Gly Ala Cys Gly Cys Cys Ala Gly Gly 
    530                 535                 540                 


Ala Cys Gly Gly Cys Ala Ala Gly Thr Gly Thr Cys Gly Gly Cys Ala 
545                 550                 555                 560 


Cys Thr Gly Thr Gly Gly Gly Ala Ala Gly Gly Gly Ala Thr Thr Cys 
                565                 570                 575     


Cys Ala Gly Cys Ala Gly Ala Ala Gly Thr Thr Cys Ala Cys Cys Thr 
            580                 585                 590         


Thr Cys Cys Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Gly Ala Thr 
        595                 600                 605             


Thr Gly Thr Gly Gly Cys Cys Ala Thr Cys Ala Gly Cys Thr Gly Cys 
    610                 615                 620                 


Thr Cys Gly Thr Gly Gly Thr Gly Cys Ala Ala Gly Cys Ala Gly Gly 
625                 630                 635                 640 


Cys Ala Thr Ala Cys Cys Ala Cys Ala Gly Cys Ala Ala Gly Gly Thr 
                645                 650                 655     


Gly Thr Cys Cys Thr Gly Cys Thr Thr Cys Ala Thr Gly Cys Thr Gly 
            660                 665                 670         


Cys Ala Gly Cys Ala Gly Ala Thr Cys Gly Ala Gly Gly Ala Gly Cys 
        675                 680                 685             


Cys Gly Thr Gly Cys Thr Cys Gly Cys Thr Gly Gly Gly Gly Gly Thr 
    690                 695                 700                 


Cys Cys Ala Cys Gly Cys Ala Gly Cys Cys Gly Thr Gly Gly Thr Cys 
705                 710                 715                 720 


Ala Thr Cys Cys Cys Gly Cys Cys Cys Ala Cys Cys Thr Gly Gly Ala 
                725                 730                 735     


Thr Cys Cys Thr Cys Cys Gly Cys Gly Cys Cys Cys Gly Gly Ala Gly 
            740                 745                 750         


Gly Cys Cys Cys Cys Ala Gly Ala Ala Thr Ala Cys Thr Cys Thr Gly 
        755                 760                 765             


Ala Ala Ala Gly Cys Ala Ala Gly Cys Ala Ala Gly Ala Ala Gly Ala 
    770                 775                 780                 


Ala Gly Ala Ala Gly Ala Gly Gly Gly Cys Ala Thr Cys Cys Thr Thr 
785                 790                 795                 800 


Cys Ala Ala Gly Ala Gly Gly Ala Ala Gly Thr Cys Cys Ala Gly Cys 
                805                 810                 815     


Ala Ala Gly Ala Ala Ala Gly Gly Gly Cys Cys Thr Gly Ala Gly Gly 
            820                 825                 830         


Ala Gly Gly Gly Cys Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Cys 
        835                 840                 845             


Cys Thr Thr Cys Ala Thr Cys Ala Thr Cys Ala Gly Gly Cys Cys Cys 
    850                 855                 860                 


Ala Cys Cys Cys Cys Cys Thr Cys Cys Cys Cys Gly Cys Thr Cys Ala 
865                 870                 875                 880 


Thr Gly Ala Ala Gly Cys Cys Cys Cys Thr Gly Cys Thr Gly Gly Thr 
                885                 890                 895     


Gly Thr Thr Thr Gly Thr Gly Ala Ala Cys Cys Cys Cys Ala Ala Gly 
            900                 905                 910         


Ala Gly Thr Gly Gly Gly Gly Gly Cys Ala Ala Cys Cys Ala Gly Gly 
        915                 920                 925             


Gly Thr Gly Cys Ala Ala Ala Gly Ala Thr Cys Ala Thr Cys Cys Ala 
    930                 935                 940                 


Gly Thr Cys Thr Thr Thr Cys Cys Thr Cys Thr Gly Gly Thr Ala Thr 
945                 950                 955                 960 


Cys Thr Cys Ala Ala Thr Cys Cys Cys Cys Gly Ala Cys Ala Ala Gly 
                965                 970                 975     


Thr Cys Thr Thr Cys Gly Ala Cys Cys Thr Gly Ala Gly Cys Cys Ala 
            980                 985                 990         


Gly Gly Gly Ala Gly Gly Gly Cys  Cys Cys Ala Ala Gly  Gly Ala Gly 
        995                 1000                 1005             


Gly Cys  Gly Cys Thr Gly Gly  Ala Gly Ala Thr Gly  Thr Ala Cys 
    1010                 1015                 1020             


Cys Gly  Cys Ala Ala Ala Gly  Thr Gly Cys Ala Cys  Ala Ala Cys 
    1025                 1030                 1035             


Cys Thr  Gly Cys Gly Gly Ala  Thr Cys Cys Thr Gly  Gly Cys Gly 
    1040                 1045                 1050             


Thr Gly  Cys Gly Gly Gly Gly  Gly Cys Gly Ala Cys  Gly Gly Cys 
    1055                 1060                 1065             


Ala Cys  Gly Gly Thr Gly Gly  Gly Cys Thr Gly Gly  Ala Thr Cys 
    1070                 1075                 1080             


Cys Thr  Cys Thr Cys Cys Ala  Cys Cys Cys Thr Gly  Gly Ala Cys 
    1085                 1090                 1095             


Cys Ala  Gly Cys Thr Ala Cys  Gly Cys Cys Thr Gly  Ala Ala Gly 
    1100                 1105                 1110             


Cys Cys  Gly Cys Cys Ala Cys  Cys Cys Cys Cys Thr  Gly Thr Thr 
    1115                 1120                 1125             


Gly Cys  Cys Ala Thr Cys Cys  Thr Gly Cys Cys Cys  Cys Thr Gly 
    1130                 1135                 1140             


Gly Gly  Thr Ala Cys Thr Gly  Gly Cys Ala Ala Cys  Gly Ala Cys 
    1145                 1150                 1155             


Thr Thr  Gly Gly Cys Cys Cys  Gly Ala Ala Cys Cys  Cys Thr Cys 
    1160                 1165                 1170             


Ala Ala  Cys Thr Gly Gly Gly  Gly Thr Gly Gly Gly  Gly Gly Cys 
    1175                 1180                 1185             


Thr Ala  Cys Ala Cys Ala Gly  Ala Thr Gly Ala Gly  Cys Cys Thr 
    1190                 1195                 1200             


Gly Thr  Gly Thr Cys Cys Ala  Ala Gly Ala Thr Cys  Cys Thr Cys 
    1205                 1210                 1215             


Thr Cys  Cys Cys Ala Cys Gly  Thr Gly Gly Ala Gly  Gly Ala Gly 
    1220                 1225                 1230             


Gly Gly  Gly Ala Ala Cys Gly  Thr Gly Gly Thr Ala  Cys Ala Gly 
    1235                 1240                 1245             


Cys Thr  Gly Gly Ala Cys Cys  Gly Cys Thr Gly Gly  Gly Ala Cys 
    1250                 1255                 1260             


Cys Thr  Cys Cys Ala Cys Gly  Cys Thr Gly Ala Gly  Cys Cys Cys 
    1265                 1270                 1275             


Ala Ala  Cys Cys Cys Cys Gly  Ala Gly Gly Cys Ala  Gly Gly Gly 
    1280                 1285                 1290             


Cys Cys  Thr Gly Ala Gly Gly  Ala Cys Cys Gly Ala  Gly Ala Thr 
    1295                 1300                 1305             


Gly Ala  Ala Gly Gly Cys Gly  Cys Cys Ala Cys Cys  Gly Ala Cys 
    1310                 1315                 1320             


Cys Gly  Gly Thr Thr Gly Cys  Cys Cys Cys Thr Gly  Gly Ala Thr 
    1325                 1330                 1335             


Gly Thr  Cys Thr Thr Cys Ala  Ala Cys Ala Ala Cys  Thr Ala Cys 
    1340                 1345                 1350             


Thr Thr  Cys Ala Gly Cys Cys  Thr Gly Gly Gly Cys  Thr Thr Thr 
    1355                 1360                 1365             


Gly Ala  Cys Gly Cys Cys Cys  Ala Cys Gly Thr Cys  Ala Cys Cys 
    1370                 1375                 1380             


Cys Thr  Gly Gly Ala Gly Thr  Thr Cys Cys Ala Cys  Gly Ala Gly 
    1385                 1390                 1395             


Thr Cys  Thr Cys Gly Ala Gly  Ala Gly Gly Cys Cys  Ala Ala Cys 
    1400                 1405                 1410             


Cys Cys  Ala Gly Ala Gly Ala  Ala Ala Thr Thr Cys  Ala Ala Cys 
    1415                 1420                 1425             


Ala Gly  Cys Cys Gly Cys Thr  Thr Thr Cys Gly Gly  Ala Ala Thr 
    1430                 1435                 1440             


Ala Ala  Gly Ala Thr Gly Thr  Thr Cys Thr Ala Cys  Gly Cys Cys 
    1445                 1450                 1455             


Gly Gly  Gly Ala Cys Ala Gly  Cys Thr Thr Thr Cys  Thr Cys Thr 
    1460                 1465                 1470             


Gly Ala  Cys Thr Thr Cys Cys  Thr Gly Ala Thr Gly  Gly Gly Cys 
    1475                 1480                 1485             


Ala Gly  Cys Thr Cys Cys Ala  Ala Gly Gly Ala Cys  Cys Thr Gly 
    1490                 1495                 1500             


Gly Cys  Cys Ala Ala Gly Cys  Ala Cys Ala Thr Cys  Cys Gly Ala 
    1505                 1510                 1515             


Gly Thr  Gly Gly Thr Gly Thr  Gly Thr Gly Ala Thr  Gly Gly Ala 
    1520                 1525                 1530             


Ala Thr  Gly Gly Ala Cys Thr  Thr Gly Ala Cys Thr  Cys Cys Cys 
    1535                 1540                 1545             


Ala Ala  Gly Ala Thr Cys Cys  Ala Gly Gly Ala Cys  Cys Thr Gly 
    1550                 1555                 1560             


Ala Ala  Ala Cys Cys Cys Cys  Ala Gly Thr Gly Thr  Gly Thr Thr 
    1565                 1570                 1575             


Gly Thr  Thr Thr Thr Cys Cys  Thr Gly Ala Ala Cys  Ala Thr Cys 
    1580                 1585                 1590             


Cys Cys  Cys Ala Gly Gly Thr  Ala Cys Thr Gly Thr  Gly Cys Gly 
    1595                 1600                 1605             


Gly Gly  Cys Ala Cys Cys Ala  Thr Gly Cys Cys Cys  Thr Gly Gly 
    1610                 1615                 1620             


Gly Gly  Cys Cys Ala Cys Cys  Cys Thr Gly Gly Gly  Gly Ala Gly 
    1625                 1630                 1635             


Cys Ala  Cys Cys Ala Cys Gly  Ala Cys Thr Thr Thr  Gly Ala Gly 
    1640                 1645                 1650             


Cys Cys  Cys Cys Ala Gly Cys  Gly Gly Cys Ala Thr  Gly Ala Cys 
    1655                 1660                 1665             


Gly Ala  Cys Gly Gly Cys Thr  Ala Cys Cys Thr Cys  Gly Ala Gly 
    1670                 1675                 1680             


Gly Thr  Cys Ala Thr Thr Gly  Gly Cys Thr Thr Cys  Ala Cys Cys 
    1685                 1690                 1695             


Ala Thr  Gly Ala Cys Gly Thr  Cys Gly Thr Thr Gly  Gly Cys Cys 
    1700                 1705                 1710             


Gly Cys  Gly Cys Thr Gly Cys  Ala Gly Gly Thr Gly  Gly Gly Cys 
    1715                 1720                 1725             


Gly Gly  Ala Cys Ala Cys Gly  Gly Cys Gly Ala Gly  Cys Gly Gly 
    1730                 1735                 1740             


Cys Thr  Gly Ala Cys Gly Cys  Ala Gly Thr Gly Thr  Cys Gly Cys 
    1745                 1750                 1755             


Gly Ala  Gly Gly Thr Gly Gly  Thr Gly Cys Thr Cys  Ala Cys Cys 
    1760                 1765                 1770             


Ala Cys  Ala Thr Cys Cys Ala  Ala Gly Gly Cys Cys  Ala Thr Cys 
    1775                 1780                 1785             


Cys Cys  Gly Gly Thr Gly Cys  Ala Gly Gly Thr Gly  Gly Ala Thr 
    1790                 1795                 1800             


Gly Gly  Cys Gly Ala Gly Cys  Cys Cys Thr Gly Cys  Ala Ala Gly 
    1805                 1810                 1815             


Cys Thr  Thr Gly Cys Ala Gly  Cys Cys Thr Cys Ala  Cys Gly Cys 
    1820                 1825                 1830             


Ala Thr  Cys Cys Gly Cys Ala  Thr Cys Gly Cys Cys  Cys Thr Gly 
    1835                 1840                 1845             


Cys Gly  Cys Ala Ala Cys Cys  Ala Gly Gly Cys Cys  Ala Cys Cys 
    1850                 1855                 1860             


Ala Thr  Gly Gly Thr Gly Cys  Ala Gly Ala Ala Gly  Gly Cys Cys 
    1865                 1870                 1875             


Ala Ala  Gly Cys Gly Gly Cys  Gly Gly Ala Gly Cys  Gly Cys Cys 
    1880                 1885                 1890             


Gly Cys  Cys Cys Cys Cys Cys  Thr Gly Cys Ala Cys  Ala Gly Cys 
    1895                 1900                 1905             


Gly Ala  Cys Cys Ala Gly Cys  Ala Gly Cys Cys Gly  Gly Thr Gly 
    1910                 1915                 1920             


Cys Cys  Ala Gly Ala Gly Cys  Ala Gly Thr Thr Gly  Cys Gly Cys 
    1925                 1930                 1935             


Ala Thr  Cys Cys Ala Gly Gly  Thr Gly Ala Gly Thr  Cys Gly Cys 
    1940                 1945                 1950             


Gly Thr  Cys Ala Gly Cys Ala  Thr Gly Cys Ala Cys  Gly Ala Cys 
    1955                 1960                 1965             


Thr Ala  Thr Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1970                 1975                 1980             


Thr Ala  Cys Gly Ala Cys Ala  Ala Gly Gly Ala Gly  Cys Ala Gly 
    1985                 1990                 1995             


Cys Thr  Cys Ala Ala Gly Gly  Ala Gly Gly Cys Cys  Thr Cys Thr 
    2000                 2005                 2010             


Gly Thr  Gly Cys Cys Gly Cys  Thr Gly Gly Gly Cys  Ala Cys Thr 
    2015                 2020                 2025             


Gly Thr  Gly Gly Thr Gly Gly  Thr Cys Cys Cys Ala  Gly Gly Ala 
    2030                 2035                 2040             


Gly Ala  Cys Ala Gly Thr Gly  Ala Cys Cys Thr Ala  Gly Ala Gly 
    2045                 2050                 2055             


Cys Thr  Cys Thr Gly Cys Cys  Gly Thr Gly Cys Cys  Cys Ala Cys 
    2060                 2065                 2070             


Ala Thr  Thr Gly Ala Gly Ala  Gly Ala Cys Thr Cys  Cys Ala Gly 
    2075                 2080                 2085             


Cys Ala  Gly Gly Ala Gly Cys  Cys Cys Gly Ala Thr  Gly Gly Thr 
    2090                 2095                 2100             


Gly Cys  Thr Gly Gly Ala Gly  Cys Cys Ala Ala Gly  Thr Cys Cys 
    2105                 2110                 2115             


Cys Cys  Gly Ala Cys Ala Thr  Gly Cys Cys Ala Gly  Ala Ala Ala 
    2120                 2125                 2130             


Cys Thr  Gly Thr Cys Cys Cys  Cys Cys Ala Ala Gly  Thr Gly Gly 
    2135                 2140                 2145             


Thr Gly  Cys Thr Thr Cys Cys  Thr Gly Gly Ala Cys  Gly Cys Cys 
    2150                 2155                 2160             


Ala Cys  Cys Ala Cys Thr Gly  Cys Cys Ala Gly Cys  Cys Gly Cys 
    2165                 2170                 2175             


Thr Thr  Cys Thr Ala Cys Ala  Gly Gly Ala Thr Cys  Gly Ala Cys 
    2180                 2185                 2190             


Cys Gly  Ala Gly Cys Cys Cys  Ala Gly Gly Ala Gly  Cys Ala Cys 
    2195                 2200                 2205             


Cys Thr  Cys Ala Ala Cys Thr  Ala Thr Gly Thr Gly  Ala Cys Thr 
    2210                 2215                 2220             


Gly Ala  Gly Ala Thr Cys Gly  Cys Ala Cys Ala Gly  Gly Ala Thr 
    2225                 2230                 2235             


Gly Ala  Gly Ala Thr Thr Thr  Ala Thr Ala Thr Cys  Cys Thr Gly 
    2240                 2245                 2250             


Gly Ala  Cys Cys Cys Thr Gly  Ala Gly Cys Thr Gly  Cys Thr Gly 
    2255                 2260                 2265             


Gly Gly  Gly Gly Cys Ala Thr  Cys Gly Gly Cys Cys  Cys Gly Gly 
    2270                 2275                 2280             


Cys Cys  Thr Gly Ala Cys Cys  Thr Cys Cys Cys Ala  Ala Cys Cys 
    2285                 2290                 2295             


Cys Cys  Cys Ala Cys Thr Thr  Cys Cys Cys Cys Thr  Cys Thr Cys 
    2300                 2305                 2310             


Cys Cys  Cys Ala Cys Cys Thr  Cys Ala Cys Cys Cys  Thr Gly Cys 
    2315                 2320                 2325             


Thr Cys  Ala Cys Cys Cys Ala  Cys Gly Cys Cys Cys  Cys Gly Gly 
    2330                 2335                 2340             


Thr Cys  Ala Cys Thr Gly Cys  Ala Ala Gly Gly Gly  Gly Ala Thr 
    2345                 2350                 2355             


Gly Cys  Thr Gly Cys Ala Cys  Cys Cys Cys Cys Thr  Cys Ala Ala 
    2360                 2365                 2370             


Gly Gly  Thr Gly Ala Ala Gly  Ala Gly Cys Thr Gly  Ala Thr Thr 
    2375                 2380                 2385             


Gly Ala  Gly Gly Cys Thr Gly  Cys Cys Ala Ala Gly  Ala Gly Gly 
    2390                 2395                 2400             


Ala Ala  Cys Gly Ala Cys Thr  Thr Cys Thr Gly Thr  Ala Ala Gly 
    2405                 2410                 2415             


Cys Thr  Cys Cys Ala Gly Gly  Ala Gly Cys Thr Gly  Cys Ala Cys 
    2420                 2425                 2430             


Cys Gly  Ala Gly Cys Thr Gly  Gly Gly Gly Gly Cys  Gly Ala Cys 
    2435                 2440                 2445             


Cys Thr  Cys Ala Thr Gly Cys  Ala Cys Cys Gly Ala  Gly Ala Cys 
    2450                 2455                 2460             


Gly Ala  Gly Cys Ala Gly Ala  Gly Thr Cys Gly Cys  Ala Cys Gly 
    2465                 2470                 2475             


Cys Thr  Cys Cys Thr Gly Cys  Ala Cys Cys Ala Cys  Gly Cys Ala 
    2480                 2485                 2490             


Gly Thr  Cys Ala Gly Cys Ala  Cys Thr Gly Gly Cys  Ala Gly Cys 
    2495                 2500                 2505             


Ala Ala  Gly Gly Ala Thr Gly  Thr Gly Gly Thr Cys  Cys Gly Cys 
    2510                 2515                 2520             


Thr Ala  Cys Cys Thr Gly Cys  Thr Gly Gly Ala Cys  Cys Ala Cys 
    2525                 2530                 2535             


Gly Cys  Cys Cys Cys Cys Cys  Cys Ala Gly Ala Gly  Ala Thr Cys 
    2540                 2545                 2550             


Cys Thr  Thr Gly Ala Thr Gly  Cys Gly Gly Thr Gly  Gly Ala Gly 
    2555                 2560                 2565             


Gly Ala  Ala Ala Ala Cys Gly  Gly Gly Gly Ala Gly  Ala Cys Cys 
    2570                 2575                 2580             


Thr Gly  Thr Thr Thr Gly Cys  Ala Cys Cys Ala Ala  Gly Cys Ala 
    2585                 2590                 2595             


Gly Cys  Gly Gly Cys Cys Cys  Thr Gly Gly Gly Cys  Cys Ala Gly 
    2600                 2605                 2610             


Cys Gly  Cys Ala Cys Cys Ala  Thr Cys Thr Gly Cys  Cys Ala Cys 
    2615                 2620                 2625             


Thr Ala  Cys Ala Thr Cys Gly  Thr Gly Gly Ala Gly  Gly Cys Cys 
    2630                 2635                 2640             


Gly Gly  Gly Gly Cys Cys Thr  Cys Gly Cys Thr Cys  Ala Thr Gly 
    2645                 2650                 2655             


Ala Ala  Gly Ala Cys Ala Gly  Ala Cys Cys Ala Gly  Cys Ala Gly 
    2660                 2665                 2670             


Gly Gly  Cys Gly Ala Cys Ala  Cys Thr Cys Cys Cys  Cys Gly Gly 
    2675                 2680                 2685             


Cys Ala  Gly Cys Gly Gly Gly  Cys Thr Gly Ala Gly  Ala Ala Gly 
    2690                 2695                 2700             


Gly Cys  Thr Cys Ala Gly Gly  Ala Cys Ala Cys Cys  Gly Ala Gly 
    2705                 2710                 2715             


Cys Thr  Gly Gly Cys Cys Gly  Cys Cys Thr Ala Cys  Cys Thr Gly 
    2720                 2725                 2730             


Gly Ala  Gly Ala Ala Cys Cys  Gly Gly Cys Ala Gly  Cys Ala Cys 
    2735                 2740                 2745             


Thr Ala  Cys Cys Ala Gly Ala  Thr Gly Ala Thr Cys  Cys Ala Gly 
    2750                 2755                 2760             


Cys Gly  Gly Gly Ala Gly Gly  Ala Cys Cys Ala Gly  Gly Ala Gly 
    2765                 2770                 2775             


Ala Cys  Gly Gly Cys Thr Gly  Thr Gly Gly Gly Ala  Thr Cys Cys 
    2780                 2785                 2790             


Thr Cys  Gly Gly Ala Gly Ala  Cys Ala Gly Thr Gly  Cys Gly Gly 
    2795                 2800                 2805             


Thr Thr  Thr Cys Ala Gly Gly  Gly Ala Cys Ala Cys  Cys Ala Cys 
    2810                 2815                 2820             


Cys Ala  Cys Cys Ala Thr Cys  Ala Cys Cys Ala Cys  Thr Gly Ala 
    2825                 2830                 2835             


<210>  4
<211>  945
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Pro Arg Asp Gly Ser Pro Glu Ala Arg Ser Ser Asp Ser Glu 
1               5                   10                  15      


Ser Ala Ser Ala Ser Ser Ser Gly Ser Glu Arg Asp Ala Gly Pro Glu 
            20                  25                  30          


Pro Asp Lys Ala Pro Arg Arg Leu Asn Lys Arg Arg Phe Pro Gly Leu 
        35                  40                  45              


Arg Leu Phe Gly His Arg Lys Ala Ile Thr Lys Ser Gly Leu Gln His 
    50                  55                  60                  


Leu Ala Pro Pro Pro Pro Thr Pro Gly Ala Pro Cys Ser Glu Ser Glu 
65                  70                  75                  80  


Arg Gln Ile Arg Ser Thr Val Asp Trp Ser Glu Ser Ala Thr Tyr Gly 
                85                  90                  95      


Glu His Ile Trp Phe Glu Thr Asn Val Ser Gly Asp Phe Cys Tyr Val 
            100                 105                 110         


Gly Glu Gln Tyr Cys Val Ala Arg Met Leu Gln Lys Ser Val Ser Arg 
        115                 120                 125             


Arg Lys Cys Ala Ala Cys Lys Ile Val Val His Thr Pro Cys Ile Glu 
    130                 135                 140                 


Gln Leu Glu Lys Ile Asn Phe Arg Cys Lys Pro Ser Phe Arg Glu Ser 
145                 150                 155                 160 


Gly Ser Arg Asn Val Arg Glu Pro Thr Phe Val Arg His His Trp Val 
                165                 170                 175     


His Arg Arg Arg Gln Asp Gly Lys Cys Arg His Cys Gly Lys Gly Phe 
            180                 185                 190         


Gln Gln Lys Phe Thr Phe His Ser Lys Glu Ile Val Ala Ile Ser Cys 
        195                 200                 205             


Ser Trp Cys Lys Gln Ala Tyr His Ser Lys Val Ser Cys Phe Met Leu 
    210                 215                 220                 


Gln Gln Ile Glu Glu Pro Cys Ser Leu Gly Val His Ala Ala Val Val 
225                 230                 235                 240 


Ile Pro Pro Thr Trp Ile Leu Arg Ala Arg Arg Pro Gln Asn Thr Leu 
                245                 250                 255     


Lys Ala Ser Lys Lys Lys Lys Arg Ala Ser Phe Lys Arg Lys Ser Ser 
            260                 265                 270         


Lys Lys Gly Pro Glu Glu Gly Arg Trp Arg Pro Phe Ile Ile Arg Pro 
        275                 280                 285             


Thr Pro Ser Pro Leu Met Lys Pro Leu Leu Val Phe Val Asn Pro Lys 
    290                 295                 300                 


Ser Gly Gly Asn Gln Gly Ala Lys Ile Ile Gln Ser Phe Leu Trp Tyr 
305                 310                 315                 320 


Leu Asn Pro Arg Gln Val Phe Asp Leu Ser Gln Gly Gly Pro Lys Glu 
                325                 330                 335     


Ala Leu Glu Met Tyr Arg Lys Val His Asn Leu Arg Ile Leu Ala Cys 
            340                 345                 350         


Gly Gly Asp Gly Thr Val Gly Trp Ile Leu Ser Thr Leu Asp Gln Leu 
        355                 360                 365             


Arg Leu Lys Pro Pro Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly 
    370                 375                 380                 


Asn Asp Leu Ala Arg Thr Leu Asn Trp Gly Gly Gly Tyr Thr Asp Glu 
385                 390                 395                 400 


Pro Val Ser Lys Ile Leu Ser His Val Glu Glu Gly Asn Val Val Gln 
                405                 410                 415     


Leu Asp Arg Trp Asp Leu His Ala Glu Pro Asn Pro Glu Ala Gly Pro 
            420                 425                 430         


Glu Asp Arg Asp Glu Gly Ala Thr Asp Arg Leu Pro Leu Asp Val Phe 
        435                 440                 445             


Asn Asn Tyr Phe Ser Leu Gly Phe Asp Ala His Val Thr Leu Glu Phe 
    450                 455                 460                 


His Glu Ser Arg Glu Ala Asn Pro Glu Lys Phe Asn Ser Arg Phe Arg 
465                 470                 475                 480 


Asn Lys Met Phe Tyr Ala Gly Thr Ala Phe Ser Asp Phe Leu Met Gly 
                485                 490                 495     


Ser Ser Lys Asp Leu Ala Lys His Ile Arg Val Val Cys Asp Gly Met 
            500                 505                 510         


Asp Leu Thr Pro Lys Ile Gln Asp Leu Lys Pro Gln Cys Val Val Phe 
        515                 520                 525             


Leu Asn Ile Pro Arg Tyr Cys Ala Gly Thr Met Pro Trp Gly His Pro 
    530                 535                 540                 


Gly Glu His His Asp Phe Glu Pro Gln Arg His Asp Asp Gly Tyr Leu 
545                 550                 555                 560 


Glu Val Ile Gly Phe Thr Met Thr Ser Leu Ala Ala Leu Gln Val Gly 
                565                 570                 575     


Gly His Gly Glu Arg Leu Thr Gln Cys Arg Glu Val Val Leu Thr Thr 
            580                 585                 590         


Ser Lys Ala Ile Pro Val Gln Val Asp Gly Glu Pro Cys Lys Leu Ala 
        595                 600                 605             


Ala Ser Arg Ile Arg Ile Ala Leu Arg Asn Gln Ala Thr Met Val Gln 
    610                 615                 620                 


Lys Ala Lys Arg Arg Ser Ala Ala Pro Leu His Ser Asp Gln Gln Pro 
625                 630                 635                 640 


Val Pro Glu Gln Leu Arg Ile Gln Val Ser Arg Val Ser Met His Asp 
                645                 650                 655     


Tyr Glu Ala Leu His Tyr Asp Lys Glu Gln Leu Lys Glu Ala Ser Val 
            660                 665                 670         


Pro Leu Gly Thr Val Val Val Pro Gly Asp Ser Asp Leu Glu Leu Cys 
        675                 680                 685             


Arg Ala His Ile Glu Arg Leu Gln Gln Glu Pro Asp Gly Ala Gly Ala 
    690                 695                 700                 


Lys Ser Pro Thr Cys Gln Lys Leu Ser Pro Lys Trp Cys Phe Leu Asp 
705                 710                 715                 720 


Ala Thr Thr Ala Ser Arg Phe Tyr Arg Ile Asp Arg Ala Gln Glu His 
                725                 730                 735     


Leu Asn Tyr Val Thr Glu Ile Ala Gln Asp Glu Ile Tyr Ile Leu Asp 
            740                 745                 750         


Pro Glu Leu Leu Gly Ala Ser Ala Arg Pro Asp Leu Pro Thr Pro Thr 
        755                 760                 765             


Ser Pro Leu Pro Thr Ser Pro Cys Ser Pro Thr Pro Arg Ser Leu Gln 
    770                 775                 780                 


Gly Asp Ala Ala Pro Pro Gln Gly Glu Glu Leu Ile Glu Ala Ala Lys 
785                 790                 795                 800 


Arg Asn Asp Phe Cys Lys Leu Gln Glu Leu His Arg Ala Gly Gly Asp 
                805                 810                 815     


Leu Met His Arg Asp Glu Gln Ser Arg Thr Leu Leu His His Ala Val 
            820                 825                 830         


Ser Thr Gly Ser Lys Asp Val Val Arg Tyr Leu Leu Asp His Ala Pro 
        835                 840                 845             


Pro Glu Ile Leu Asp Ala Val Glu Glu Asn Gly Glu Thr Cys Leu His 
    850                 855                 860                 


Gln Ala Ala Ala Leu Gly Gln Arg Thr Ile Cys His Tyr Ile Val Glu 
865                 870                 875                 880 


Ala Gly Ala Ser Leu Met Lys Thr Asp Gln Gln Gly Asp Thr Pro Arg 
                885                 890                 895     


Gln Arg Ala Glu Lys Ala Gln Asp Thr Glu Leu Ala Ala Tyr Leu Glu 
            900                 905                 910         


Asn Arg Gln His Tyr Gln Met Ile Gln Arg Glu Asp Gln Glu Thr Ala 
        915                 920                 925             


Val Gly Ser Ser Glu Thr Val Arg Phe Gln Gly His His His His His 
    930                 935                 940                 


His 
945 


