                         SEQUENCE LISTING

<110>  New England Biolabs, Inc.
 
<120>  Enzymatic RNA Capping Method

<130>  NEB-423

<150>  62/890,821
<151>  2019-08-23

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  844
<212>  PRT
<213>  Vaccinia virus


<220>
<221>  misc_feature
<223>  FL VCE capping enzyme

       >YP_232988.1 large subunit of mRNA capping enzyme

<400>  1

Met Asp Ala Asn Val Val Ser Ser Ser Thr Ile Ala Thr Tyr Ile Asp 
1               5                   10                  15      


Ala Leu Ala Lys Asn Ala Ser Glu Leu Glu Gln Arg Ser Thr Ala Tyr 
            20                  25                  30          


Glu Ile Asn Asn Glu Leu Glu Leu Val Phe Ile Lys Pro Pro Leu Ile 
        35                  40                  45              


Thr Leu Thr Asn Val Val Asn Ile Ser Thr Ile Gln Glu Ser Phe Ile 
    50                  55                  60                  


Arg Phe Thr Val Thr Asn Lys Glu Gly Val Lys Ile Arg Thr Lys Ile 
65                  70                  75                  80  


Pro Leu Ser Lys Val His Gly Leu Asp Val Lys Asn Val Gln Leu Val 
                85                  90                  95      


Asp Ala Ile Asp Asn Ile Val Trp Glu Lys Lys Ser Leu Val Thr Glu 
            100                 105                 110         


Asn Arg Leu His Lys Glu Cys Leu Leu Arg Leu Ser Thr Glu Glu Arg 
        115                 120                 125             


His Ile Phe Leu Asp Tyr Lys Lys Tyr Gly Ser Ser Ile Arg Leu Glu 
    130                 135                 140                 


Leu Val Asn Leu Ile Gln Ala Lys Thr Lys Asn Phe Thr Ile Asp Phe 
145                 150                 155                 160 


Lys Leu Lys Tyr Phe Leu Gly Ser Gly Ala Gln Ser Lys Ser Ser Leu 
                165                 170                 175     


Leu His Ala Ile Asn His Pro Lys Ser Arg Pro Asn Thr Ser Leu Glu 
            180                 185                 190         


Ile Glu Phe Thr Pro Arg Asp Asn Glu Thr Val Pro Tyr Asp Glu Leu 
        195                 200                 205             


Ile Lys Glu Leu Thr Thr Leu Ser Arg His Ile Phe Met Ala Ser Pro 
    210                 215                 220                 


Glu Asn Val Ile Leu Ser Pro Pro Ile Asn Ala Pro Ile Lys Thr Phe 
225                 230                 235                 240 


Met Leu Pro Lys Gln Asp Ile Val Gly Leu Asp Leu Glu Asn Leu Tyr 
                245                 250                 255     


Ala Val Thr Lys Thr Asp Gly Ile Pro Ile Thr Ile Arg Val Thr Ser 
            260                 265                 270         


Asn Gly Leu Tyr Cys Tyr Phe Thr His Leu Gly Tyr Ile Ile Arg Tyr 
        275                 280                 285             


Pro Val Lys Arg Ile Ile Asp Ser Glu Val Val Val Phe Gly Glu Ala 
    290                 295                 300                 


Val Lys Asp Lys Asn Trp Thr Val Tyr Leu Ile Lys Leu Ile Glu Pro 
305                 310                 315                 320 


Val Asn Ala Ile Asn Asp Arg Leu Glu Glu Ser Lys Tyr Val Glu Ser 
                325                 330                 335     


Lys Leu Val Asp Ile Cys Asp Arg Ile Val Phe Lys Ser Lys Lys Tyr 
            340                 345                 350         


Glu Gly Pro Phe Thr Thr Thr Ser Glu Val Val Asp Met Leu Ser Thr 
        355                 360                 365             


Tyr Leu Pro Lys Gln Pro Glu Gly Val Ile Leu Phe Tyr Ser Lys Gly 
    370                 375                 380                 


Pro Lys Ser Asn Ile Asp Phe Lys Ile Lys Lys Glu Asn Thr Ile Asp 
385                 390                 395                 400 


Gln Thr Ala Asn Val Val Phe Arg Tyr Met Ser Ser Glu Pro Ile Ile 
                405                 410                 415     


Phe Gly Glu Ser Ser Ile Phe Val Glu Tyr Lys Lys Phe Ser Asn Asp 
            420                 425                 430         


Lys Gly Phe Pro Lys Glu Tyr Gly Ser Gly Lys Ile Val Leu Tyr Asn 
        435                 440                 445             


Gly Val Asn Tyr Leu Asn Asn Ile Tyr Cys Leu Glu Tyr Ile Asn Thr 
    450                 455                 460                 


His Asn Glu Val Gly Ile Lys Ser Val Val Val Pro Ile Lys Phe Ile 
465                 470                 475                 480 


Ala Glu Phe Leu Val Asn Gly Glu Ile Leu Lys Pro Arg Ile Asp Lys 
                485                 490                 495     


Thr Met Lys Tyr Ile Asn Ser Glu Asp Tyr Tyr Gly Asn Gln His Asn 
            500                 505                 510         


Ile Ile Val Glu His Leu Arg Asp Gln Ser Ile Lys Ile Gly Asp Ile 
        515                 520                 525             


Phe Asn Glu Asp Lys Leu Ser Asp Val Gly His Gln Tyr Ala Asn Asn 
    530                 535                 540                 


Asp Lys Phe Arg Leu Asn Pro Glu Val Ser Tyr Phe Thr Asn Lys Arg 
545                 550                 555                 560 


Thr Arg Gly Pro Leu Gly Ile Leu Ser Asn Tyr Val Lys Thr Leu Leu 
                565                 570                 575     


Ile Ser Met Tyr Cys Ser Lys Thr Phe Leu Asp Asp Ser Asn Lys Arg 
            580                 585                 590         


Lys Val Leu Ala Ile Asp Phe Gly Asn Gly Ala Asp Leu Glu Lys Tyr 
        595                 600                 605             


Phe Tyr Gly Glu Ile Ala Leu Leu Val Ala Thr Asp Pro Asp Ala Asp 
    610                 615                 620                 


Ala Ile Ala Arg Gly Asn Glu Arg Tyr Asn Lys Leu Asn Ser Gly Ile 
625                 630                 635                 640 


Lys Thr Lys Tyr Tyr Lys Phe Asp Tyr Ile Gln Glu Thr Ile Arg Ser 
                645                 650                 655     


Asp Thr Phe Val Ser Ser Val Arg Glu Val Phe Tyr Phe Gly Lys Phe 
            660                 665                 670         


Asn Ile Ile Asp Trp Gln Phe Ala Ile His Tyr Ser Phe His Pro Arg 
        675                 680                 685             


His Tyr Ala Thr Val Met Asn Asn Leu Ser Glu Leu Thr Ala Ser Gly 
    690                 695                 700                 


Gly Lys Val Leu Ile Thr Thr Met Asp Gly Asp Lys Leu Ser Lys Leu 
705                 710                 715                 720 


Thr Asp Lys Lys Thr Phe Ile Ile His Lys Asn Leu Pro Ser Ser Glu 
                725                 730                 735     


Asn Tyr Met Ser Val Glu Lys Ile Ala Asp Asp Arg Ile Val Val Tyr 
            740                 745                 750         


Asn Pro Ser Thr Met Ser Thr Pro Met Thr Glu Tyr Ile Ile Lys Lys 
        755                 760                 765             


Asn Asp Ile Val Arg Val Phe Asn Glu Tyr Gly Phe Val Leu Val Asp 
    770                 775                 780                 


Asn Val Asp Phe Ala Thr Ile Ile Glu Arg Ser Lys Lys Phe Ile Asn 
785                 790                 795                 800 


Gly Ala Ser Thr Met Glu Asp Arg Pro Ser Thr Arg Asn Phe Phe Glu 
                805                 810                 815     


Leu Asn Arg Gly Ala Ile Lys Cys Glu Gly Leu Asp Val Glu Asp Leu 
            820                 825                 830         


Leu Ser Tyr Tyr Val Val Tyr Val Phe Ser Lys Arg 
        835                 840                 


<210>  2
<211>  60
<212>  PRT
<213>  Faustovirus


<220>
<221>  MISC_FEATURE
<223>  Fausto_CR_01

<400>  2

Phe Asp Lys Leu Lys Pro Asp Gly Glu Ile Thr Thr Thr Met Arg Val 
1               5                   10                  15      


Ser Asn Ala Asp Gly Met Ala Arg Glu Ile Thr Phe Gly Gly Gly Val 
            20                  25                  30          


Lys Thr Gly Glu Met Phe Val Lys Lys Gln Asn Ile Cys Val Phe Asp 
        35                  40                  45              


Val Val Asp Ile Phe Ser Tyr Lys Val Ala Val Ser 
    50                  55                  60  


<210>  3
<211>  111
<212>  PRT
<213>  Faustovirus


<220>
<221>  misc_feature
<223>  Fausto_CR_03

<400>  3

Gly Phe Tyr Gly Asn Asn Tyr Lys Ile Ala Ser Asp Ile Tyr Leu Asn 
1               5                   10                  15      


Tyr Ile Asp Val Phe Asn Phe Asp Asp Leu Trp Lys Tyr Asn Pro Gly 
            20                  25                  30          


Tyr Phe Glu Lys Asn Lys Ser Asp Ile Tyr Ile Ala Pro Asn Lys Tyr 
        35                  40                  45              


Arg Arg Tyr Leu Ile Lys Ser Leu Phe Asn Lys Tyr Ile Lys Asn Ala 
    50                  55                  60                  


Lys Trp Val Ile Asp Ala Ala Ala Gly Arg Gly Ala Asp Leu His Leu 
65                  70                  75                  80  


Tyr Lys Ala Glu Cys Val Glu Asn Leu Leu Ala Ile Asp Ile Asp Pro 
                85                  90                  95      


Thr Ala Ile Ser Glu Leu Ile Arg Arg Arg Asn Glu Ile Thr Gly 
            100                 105                 110     


<210>  4
<211>  60
<212>  PRT
<213>  Faustovirus


<220>
<221>  MISC_FEATURE
<223>  Fausto_CR_05

<400>  4

Lys Tyr Ser Ile Lys Arg Leu Tyr Asp Ser Asp Lys Leu Thr Lys Thr 
1               5                   10                  15      


Gly Gln Lys Ile Ala Val Leu Leu Pro Met Ser Gly Glu Met Lys Glu 
            20                  25                  30          


Glu Pro Leu Cys Asn Ile Lys Asn Ile Ile Ser Met Ala Arg Lys Met 
        35                  40                  45              


Gly Leu Asp Leu Val Glu Ser Ala Asn Phe Ser Val 
    50                  55                  60  


<210>  5
<211>  67
<212>  PRT
<213>  Mimivirus


<220>
<221>  MISC_FEATURE
<223>  5: mimi_CR_03

<400>  5

Ile Asn Asp Asn Thr Val Val Glu Phe Ile Phe Asp Asn Phe Lys Ile 
1               5                   10                  15      


Asp Met Asp Asp Pro Tyr Lys Trp Ile Pro Ile Arg Thr Arg Tyr Asp 
            20                  25                  30          


Lys Thr Glu Ser Val Gln Lys Tyr His Lys Lys Tyr Gly Asn Asn Leu 
        35                  40                  45              


His Ile Ala Asn Arg Ile Trp Lys Thr Ile Thr Asn Pro Ile Thr Glu 
    50                  55                  60                  


Asp Ile Ile 
65          


<210>  6
<211>  111
<212>  PRT
<213>  Mimivirus


<220>
<221>  MISC_FEATURE
<223>  mimi_CR_04

<400>  6

Tyr Tyr Gln Lys Asn Thr Ser Asn Ala Ala Gly Met Arg Ala Phe Asn 
1               5                   10                  15      


Asn Phe Ile Lys Ser Asn Met Ile Thr Thr Tyr Cys Lys Asp Gly Asp 
            20                  25                  30          


Lys Val Leu Asp Ile Gly Cys Gly Arg Gly Gly Asp Leu Ile Lys Phe 
        35                  40                  45              


Ile His Ala Gly Ile Glu Glu Tyr Val Gly Ile Asp Ile Asp Asn Asn 
    50                  55                  60                  


Gly Leu Tyr Val Ile Asn Asp Ser Ala Phe Asn Arg Tyr Lys Asn Leu 
65                  70                  75                  80  


Lys Lys Thr Ile Lys Asn Ile Pro Pro Met Thr Phe Ile Asn Ala Asp 
                85                  90                  95      


Ala Arg Gly Leu Phe Asn Leu Glu Ala Gln Glu Lys Ile Leu Pro 
            100                 105                 110     


<210>  7
<211>  873
<212>  PRT
<213>  Faustovirus


<220>
<221>  MISC_FEATURE
<223>  Faustovirus D5b RNA capping enzyme Genbank accession no. AMN83561

<400>  7

Met Ala Lys Arg Leu Gln Arg Cys Gln Asp Val Asn Gln Val Cys Glu 
1               5                   10                  15      


Ile Tyr Asn Ser Lys Gly Gly Ile Gly Glu Leu Glu Leu Arg Phe Asp 
            20                  25                  30          


Lys Leu Pro Gln Asn Leu Phe Ala Gly Val Phe Asp Lys Leu Lys Pro 
        35                  40                  45              


Asp Gly Glu Ile Gln Thr Thr Met Arg Val Ser Asn Arg Asp Gly Val 
    50                  55                  60                  


Ala Arg Glu Ile Thr Phe Gly Gly Gly Val Lys Thr Asn Glu Ile Phe 
65                  70                  75                  80  


Val Lys Lys Gln Asn Ile Cys Val Phe Asp Val Val Asp Ile Phe Ser 
                85                  90                  95      


Tyr Lys Val Ala Val Ser Thr Glu Glu Thr Val Val Glu Lys Pro Thr 
            100                 105                 110         


Met Glu Thr Thr Ala Gly Val Arg Phe Lys Ile Arg Leu Ser Val Glu 
        115                 120                 125             


Asp Val Val Lys Asp Trp Arg Ile Asp Leu Thr Ala Val Lys Thr Ala 
    130                 135                 140                 


Glu Leu Gly Lys Ile Ala Gln His Thr Ala Ser Ile Val Gln Arg Thr 
145                 150                 155                 160 


Phe Pro Asp Asn Leu Leu Lys Leu Thr Gly Ala Glu Val Ala Lys Leu 
                165                 170                 175     


Ala Ala Asp Ser Tyr Glu Leu Glu Leu Glu Tyr Thr Gly Lys Ser Pro 
            180                 185                 190         


Ala Thr Asn Glu Lys Val Asn Val Ala Ala Lys Tyr Ala Val Glu Leu 
        195                 200                 205             


Leu Ser Ser Val Arg Asn Ala Asn Ser Thr Ala Ala Ala Ser Phe Gly 
    210                 215                 220                 


Glu Ser Val Ser Asp Leu Cys Arg Val Ala Lys Ile Ile His Thr His 
225                 230                 235                 240 


Glu Tyr Ala Asn Val Val Cys Arg Thr Pro Ser Phe Lys Met Leu Leu 
                245                 250                 255     


Pro Gln Val Val Ser Leu Thr Lys Ser Ser Tyr Tyr Gly Gly Leu Tyr 
            260                 265                 270         


Pro Pro Glu Asn Leu Trp Leu Ala Gly Lys Thr Asp Gly Val Arg Ala 
        275                 280                 285             


Leu Val Val Cys Glu Asp Gly Val Ala Lys Val Ile Thr Ala Glu Ser 
    290                 295                 300                 


Val Asp Ile Thr His Gly Val Cys Ser Ala Thr Thr Ile Leu Asp Cys 
305                 310                 315                 320 


Glu Leu Asn Val Asp Ala Lys Ile Leu Tyr Val Phe Asp Val Ile Ile 
                325                 330                 335     


Ser Asn Asn Thr Gln Val Tyr Thr Gln Pro Phe Ser Thr Arg Ile Thr 
            340                 345                 350         


Thr Asp Ile Ser Asp Ile Lys Ile Asp Gly Tyr Lys Ile Glu Met Lys 
        355                 360                 365             


Pro Phe Val Lys Val Val Lys Ala Asp Glu Ala Thr Phe Lys Ser Ala 
    370                 375                 380                 


Tyr Lys Ala Pro His Asn Glu Gly Leu Ile Met Ile Glu Asp Gly Ala 
385                 390                 395                 400 


Ala Tyr Ala Ala Thr Lys Thr Tyr Lys Trp Lys Pro Leu Ser His Asn 
                405                 410                 415     


Thr Ile Asp Phe Leu Ile Lys Ala Cys Pro Lys Gln Leu Ile Asn Val 
            420                 425                 430         


Asp Pro Tyr Lys Pro Arg Ala Gly Tyr Lys Leu Trp Leu Leu Phe Thr 
        435                 440                 445             


Thr Ile Ser Leu Asp Gln Gln Arg Glu Leu Gly Ile Glu Phe Ile Pro 
    450                 455                 460                 


Ala Trp Lys Ile Leu Phe Thr Asp Ile Asn Met Phe Gly Ser Arg Val 
465                 470                 475                 480 


Pro Ile Gln Phe Gln Pro Ala Ile Asn Pro Leu Ala Tyr Val Cys Tyr 
                485                 490                 495     


Leu Pro Glu Asp Val Asn Val Asn Asp Gly Asp Ile Val Glu Met Arg 
            500                 505                 510         


Ala Val Asp Gly Tyr Asp Thr Ile Pro Lys Trp Glu Leu Val Arg Ser 
        515                 520                 525             


Arg Asn Asp Arg Lys Asn Glu Pro Gly Phe Tyr Gly Asn Asn Tyr Lys 
    530                 535                 540                 


Ile Ala Ser Asp Ile Tyr Leu Asn Tyr Ile Asp Val Phe His Phe Glu 
545                 550                 555                 560 


Asp Leu Tyr Lys Tyr Asn Pro Gly Tyr Phe Glu Lys Asn Lys Ser Asp 
                565                 570                 575     


Ile Tyr Val Ala Pro Asn Lys Tyr Arg Arg Tyr Leu Ile Lys Ser Leu 
            580                 585                 590         


Phe Gly Arg Tyr Leu Arg Asp Ala Lys Trp Val Ile Asp Ala Ala Ala 
        595                 600                 605             


Gly Arg Gly Ala Asp Leu His Leu Tyr Lys Ala Glu Cys Val Glu His 
    610                 615                 620                 


Leu Leu Ala Ile Asp Ile Asp Pro Thr Ala Ile Ser Glu Leu Val Arg 
625                 630                 635                 640 


Arg Arg Asn Glu Ile Thr Gly Tyr Asn Lys Ser His Arg Gly Gly Arg 
                645                 650                 655     


Asn Met His Ser His Arg Gly Gln Ser His Cys Ala Lys Ser Thr Ser 
            660                 665                 670         


Leu His Ala Leu Val Ala Asp Leu Arg Glu Asn Pro Asp Val Leu Ile 
        675                 680                 685             


Pro Lys Ile Ile Gln Ser Arg Pro His Glu Arg Cys Tyr Asp Ala Ile 
    690                 695                 700                 


Val Ile Asn Phe Ala Ile His Tyr Leu Cys Asp Thr Asp Glu His Ile 
705                 710                 715                 720 


Arg Asp Phe Leu Ile Thr Val Ser Arg Leu Leu Ala Pro Asn Gly Val 
                725                 730                 735     


Phe Ile Phe Thr Thr Met Asp Gly Glu Ser Ile Val Lys Leu Leu Ala 
            740                 745                 750         


Asp His Lys Val Arg Pro Gly Glu Ala Trp Thr Ile His Thr Gly Asp 
        755                 760                 765             


Val Asn Ser Pro Asp Ser Thr Val Pro Lys Tyr Ser Ile Arg Arg Leu 
    770                 775                 780                 


Tyr Asp Ser Asp Lys Leu Thr Lys Thr Gly Gln Gln Ile Glu Val Leu 
785                 790                 795                 800 


Leu Pro Met Ser Gly Glu Met Lys Ala Glu Pro Leu Cys Asn Ile Lys 
                805                 810                 815     


Asn Ile Ile Ser Met Ala Arg Lys Met Gly Leu Asp Leu Val Glu Ser 
            820                 825                 830         


Ala Asn Phe Ser Val Leu Tyr Glu Ala Tyr Ala Arg Asp Tyr Pro Asp 
        835                 840                 845             


Ile Tyr Ala Arg Met Thr Pro Asp Asp Lys Leu Tyr Asn Asp Leu His 
    850                 855                 860                 


Thr Tyr Ala Val Phe Lys Arg Lys Lys 
865                 870             


<210>  8
<211>  890
<212>  PRT
<213>  Faustovirus


<220>
<221>  MISC_FEATURE
<223>  Faustovirus E12 RNA capping enzyme; Genbank accession no. 
       AIB52055

<400>  8

Met Arg Arg Val Phe Asn Ser Ala Lys Lys Gln Gln Arg Cys Asp Ser 
1               5                   10                  15      


Val Glu Gln Val Cys Glu Phe Tyr Asn Ala Asp Asn Lys Thr Asn Glu 
            20                  25                  30          


Leu Glu Leu Arg Phe Asp Lys Leu Asn Arg Glu Leu Phe Val Val Leu 
        35                  40                  45              


Phe Asp Lys Leu Lys Pro Asp Gly Glu Ile Thr Thr Thr Met Arg Val 
    50                  55                  60                  


Ser Asn Ala Asp Gly Met Ala Arg Glu Ile Thr Phe Gly Gly Gly Val 
65                  70                  75                  80  


Lys Thr Gly Glu Met Phe Val Lys Lys Gln Asn Ile Cys Val Phe Asp 
                85                  90                  95      


Val Val Asp Val Phe Ser Tyr Lys Val Ala Val Ser Ser Glu Asp Glu 
            100                 105                 110         


Ile Lys Asp Lys Pro Lys Met Asp Thr Asn Ala Ser Val Arg Phe Lys 
        115                 120                 125             


Ile Arg Leu Ser Cys Asp Thr Leu Ile Pro Asp Trp Arg Ile Asp Leu 
    130                 135                 140                 


Thr Ala Val Lys Val Ala Asp Leu Gly Lys Ile Ala Gln His Thr Ser 
145                 150                 155                 160 


Thr Val Val Leu Gln Thr Phe Pro Glu Asn Leu Leu Arg Met Lys Gly 
                165                 170                 175     


Ala Glu Val Ala Ala Leu Ala Thr Asn Ser Tyr Glu Leu Glu Leu Glu 
            180                 185                 190         


Tyr Ile Gly Lys Ser Ala Ala Ser Lys Glu Lys Val Leu Ala Ala Ala 
        195                 200                 205             


Glu Tyr Ala Met Glu Leu Leu Thr Asn Ser Arg Asn Ala Ile Ser Pro 
    210                 215                 220                 


Ala Ala Ala Thr Leu Gly Glu Ser Val Ser Asp Ile Cys Arg Ile Ala 
225                 230                 235                 240 


Lys Leu Ile His Pro Ala Glu Tyr Ala Asn Val Ile Cys Arg Thr Pro 
                245                 250                 255     


Ser Phe Lys Asn Leu Leu Pro Gln Val Ile Ser Leu Thr Lys Ser Ser 
            260                 265                 270         


Tyr Tyr Gly Gly Ile Tyr Pro Pro Val Asp Met Tyr Ile Ala Gly Lys 
        275                 280                 285             


Thr Asp Gly Val Arg Ala Leu Val Leu Cys Glu Asn Gly Val Ala Lys 
    290                 295                 300                 


Ile Ile Thr Ala Thr Thr Val Asp Thr Thr Thr Val Gly Asn Thr Pro 
305                 310                 315                 320 


Ile Thr Ile Leu Asp Cys Glu Leu Ser Thr Ser Gly His Asn Gly Ala 
                325                 330                 335     


Thr Asp Asn Lys His Leu Tyr Ile Phe Asp Val Ile Met Asn Arg Gly 
            340                 345                 350         


Val His Ser His Arg Glu Gly Phe Asn Lys Arg Ile Asp Ile Asp Leu 
        355                 360                 365             


Ser Asp Leu Thr Pro Ala Gly Tyr Thr Leu Glu Leu Lys Pro Phe Thr 
    370                 375                 380                 


Lys Leu Val Asp Ala Ala Ser Val Asn Glu Thr Thr Phe Lys Ser Val 
385                 390                 395                 400 


Phe Lys Pro Pro His Asn Glu Gly Leu Val Leu Val Glu Ser Gly Pro 
                405                 410                 415     


Pro Tyr Ala Leu Thr Lys Thr Tyr Lys Trp Lys Pro Ile Thr His Asn 
            420                 425                 430         


Thr Ile Asp Phe Leu Ile Lys Ala Cys Pro Lys Gln Leu Ile Asn Val 
        435                 440                 445             


Asp Pro Phe Lys Pro Arg Asn Gly His Asp Leu Trp Leu Leu Phe Thr 
    450                 455                 460                 


Thr Ile Ser Leu Asp Gln Gln Arg Glu Leu Gly Ile Asp Leu Ile Pro 
465                 470                 475                 480 


Ala Trp Lys Leu Leu Phe Thr Asp Val Asn Leu Phe Gly Asn Lys Ile 
                485                 490                 495     


Pro Ile Gln Phe Met Pro Ala Ile Asn Pro Leu Ala Tyr Ile Cys Tyr 
            500                 505                 510         


Leu Pro Ser Ser Thr Gly Val Asn Asp Gly Asp Ile Val Glu Met Arg 
        515                 520                 525             


Ala Val Asp Gly Phe Asp Gly Ile Pro Thr Trp Glu Leu Val Arg Thr 
    530                 535                 540                 


Arg Pro Asp Arg Lys Asp Glu Arg Gly Phe Tyr Gly Asn Asn Tyr Lys 
545                 550                 555                 560 


Ile Ala Ser Asp Ile Tyr Leu Asn Tyr Ile Asp Val Phe Asn Phe Asp 
                565                 570                 575     


Asp Leu Trp Lys Tyr Asn Pro Gly Tyr Phe Glu Lys Asn Lys Ser Asp 
            580                 585                 590         


Ile Tyr Ile Ala Pro Asn Lys Tyr Arg Arg Tyr Leu Ile Lys Ser Leu 
        595                 600                 605             


Phe Asn Lys Tyr Ile Lys Asn Ala Lys Trp Val Ile Asp Ala Ala Ala 
    610                 615                 620                 


Gly Arg Gly Ala Asp Leu His Leu Tyr Lys Gln Glu Cys Val Glu Asn 
625                 630                 635                 640 


Leu Leu Ala Ile Asp Ile Asp Pro Thr Ala Ile Ser Glu Leu Ile Arg 
                645                 650                 655     


Arg Arg Asn Glu Ile Thr Gly Trp Gln Gln Arg Gly Arg Gly Gly Asn 
            660                 665                 670         


Thr Arg His Asn Ala Arg His Asn Thr His Cys Ala Ser Ser Thr Ser 
        675                 680                 685             


Leu His Ala Leu Val Ala Asp Leu Arg Thr Glu Pro Asn Met Leu Ile 
    690                 695                 700                 


Pro Lys Ile Ile Gln Ser Arg Pro Pro Glu Arg Gly Tyr Asp Ala Ile 
705                 710                 715                 720 


Val Ile Asn Phe Ala Ile His Tyr Leu Cys Glu Thr Asp Asp Tyr Ile 
                725                 730                 735     


Arg Asn Phe Leu Ile Thr Val Ser Arg Leu Leu Ala Pro Asp Gly Val 
            740                 745                 750         


Phe Ile Phe Thr Thr Met Asp Gly Glu Ala Ile Val Asn Leu Leu Ala 
        755                 760                 765             


Glu His Lys Val Ala Pro Gly Ala Ser Trp Val Val His Thr Asp Gly 
    770                 775                 780                 


Asn Ala Asn Ala Thr Asp Ala Asn Val Val Lys Tyr Ser Ile Lys Arg 
785                 790                 795                 800 


Leu Tyr Asp Ser Asp Lys Leu Thr Lys Thr Gly Gln Lys Ile Ala Val 
                805                 810                 815     


Leu Leu Pro Met Ser Gly Glu Met Arg Glu Glu Pro Leu Cys Asn Ile 
            820                 825                 830         


Lys Asn Ile Val Ser Met Ala Arg Lys Met Gly Leu Asp Leu Val Glu 
        835                 840                 845             


Ser Ala Asn Phe Ser Val Leu Tyr Gly Ala Tyr Ala Lys Asp Tyr Pro 
    850                 855                 860                 


Glu Ile Tyr Ala Lys Leu Thr Pro Asp Asp Lys Leu Tyr Asn Asp Leu 
865                 870                 875                 880 


His Ala Phe Ala Val Phe Lys Arg Lys Lys 
                885                 890 


<210>  9
<211>  894
<212>  PRT
<213>  Faustovirus


<220>
<221>  MISC_FEATURE
<223>  Faustovirus ST1 RNA capping enzyme; Genbank accession no. 
       SME65026

<400>  9

Met Arg Arg Val Ser Asn Ser Ala Lys Lys Gln Gln Arg Cys Asp Ser 
1               5                   10                  15      


Val Glu Gln Val Cys Glu Phe Tyr Asn Ala Asp Asn Lys Thr Asn Glu 
            20                  25                  30          


Leu Glu Leu Arg Phe Asp Lys Leu Asn Arg Glu Leu Phe Val Ala Leu 
        35                  40                  45              


Phe Asp Lys Leu Lys Pro Asp Gly Glu Ile Thr Thr Thr Met Arg Val 
    50                  55                  60                  


Ser Asn Ala Asp Gly Met Ala Arg Glu Ile Thr Phe Gly Gly Gly Val 
65                  70                  75                  80  


Lys Thr Gly Glu Met Phe Val Lys Lys Gln Asn Ile Cys Val Phe Asp 
                85                  90                  95      


Val Val Asp Val Phe Ser Tyr Lys Val Ala Val Ser Ser Glu Asp Glu 
            100                 105                 110         


Val Lys Asp Lys Pro Lys Met Asp Thr Asn Ala Ser Val Arg Phe Lys 
        115                 120                 125             


Ile Arg Leu Ser Cys Asp Thr Leu Ile Pro Asp Trp Arg Ile Asp Leu 
    130                 135                 140                 


Thr Ala Val Lys Val Ala Asp Leu Gly Lys Ile Ala Gln His Thr Ser 
145                 150                 155                 160 


Thr Val Val Leu Gln Thr Phe Pro Glu Asn Leu Leu Arg Met Lys Gly 
                165                 170                 175     


Ala Glu Val Ala Ala Leu Ala Thr Asn Ser Tyr Glu Leu Glu Leu Glu 
            180                 185                 190         


Tyr Ile Gly Lys Ser Thr Ala Gly Lys Glu Lys Val Leu Lys Ala Ala 
        195                 200                 205             


Glu Tyr Ala Ile Glu Leu Leu Thr Asn Leu Arg Asn Ala Val Ser Pro 
    210                 215                 220                 


Val Ala Ala Thr Leu Gly Glu Ser Val Ser Asp Ile Cys Arg Ile Ala 
225                 230                 235                 240 


Lys Leu Ile His Pro Ala Glu Tyr Ala Asn Val Ile Cys Arg Thr Pro 
                245                 250                 255     


Ser Phe Lys Asn Leu Leu Pro Gln Val Ile Ser Leu Thr Lys Ser Ser 
            260                 265                 270         


Tyr Tyr Gly Gly Ile Tyr Pro Pro Val Asp Met Tyr Ile Thr Gly Lys 
        275                 280                 285             


Thr Asp Gly Val Arg Ala Leu Val Leu Cys Glu Asn Gly Val Ala Lys 
    290                 295                 300                 


Ile Ile Thr Ala Thr Thr Val Asp Thr Thr Thr Val Gly Asp Thr Pro 
305                 310                 315                 320 


Ile Thr Ile Leu Asp Cys Glu Leu Ser Thr Ser Gly His Asn Gly Ala 
                325                 330                 335     


Thr Asp Asn Lys His Leu Tyr Val Phe Asp Val Ile Met Asn Arg Gly 
            340                 345                 350         


Ala His Ser His Arg Asp Gly Phe Asn Lys Arg Ile Asp Ile Asp Leu 
        355                 360                 365             


Ser Asp Leu Thr Pro Ala Gly Tyr Thr Leu Glu Leu Lys Pro Phe Thr 
    370                 375                 380                 


Lys Val Ala Asp Ala Ala Ser Val Asn Glu Thr Thr Phe Lys Ser Val 
385                 390                 395                 400 


Phe Lys Pro Pro His Asn Glu Gly Leu Val Leu Val Glu Ser Gly Pro 
                405                 410                 415     


Pro Tyr Ala Leu Thr Lys Thr Tyr Lys Trp Lys Pro Ile Thr His Asn 
            420                 425                 430         


Thr Ile Asp Phe Leu Ile Lys Ala Cys Pro Lys Gln Leu Ile Asn Val 
        435                 440                 445             


Asp Pro Phe Lys Pro Arg Asn Gly His Asp Leu Trp Leu Leu Phe Thr 
    450                 455                 460                 


Thr Ile Ser Leu Asp Gln Gln Arg Glu Leu Gly Ile Asp Leu Ile Pro 
465                 470                 475                 480 


Ala Trp Lys Leu Leu Phe Thr Asp Val Asn Leu Phe Gly Asn Lys Ile 
                485                 490                 495     


Pro Ile Gln Phe Met Pro Ala Ile Asn Pro Leu Ala Tyr Ile Cys Tyr 
            500                 505                 510         


Leu Pro Ser Ser Thr Gly Val Asn Asp Gly Asp Ile Val Glu Met Arg 
        515                 520                 525             


Ala Val Asp Gly Phe Asp Gly Ile Pro Thr Trp Glu Leu Val Arg Thr 
    530                 535                 540                 


Arg Pro Asp Arg Lys Asp Glu Arg Gly Phe Tyr Gly Asn Asn Tyr Lys 
545                 550                 555                 560 


Ile Ala Ser Asp Ile Tyr Leu Asn Tyr Ile Asp Val Phe Asn Phe Asp 
                565                 570                 575     


Asp Leu Trp Lys Tyr Asn Pro Gly Tyr Phe Glu Lys Asn Lys Ser Asp 
            580                 585                 590         


Ile Tyr Ile Ala Pro Asn Lys Tyr Arg Arg Tyr Leu Ile Lys Ser Leu 
        595                 600                 605             


Phe Asn Lys Tyr Ile Lys Asn Ala Lys Trp Val Ile Asp Ala Ala Ala 
    610                 615                 620                 


Gly Arg Gly Ala Asp Leu His Leu Tyr Lys Gln Glu Cys Val Glu Asn 
625                 630                 635                 640 


Leu Leu Ala Ile Asp Ile Asp Pro Thr Ala Ile Ser Glu Leu Ile Arg 
                645                 650                 655     


Arg Arg Asn Glu Ile Thr Gly Trp Gln Gln Arg Gly Arg Gly Gly Asn 
            660                 665                 670         


Met His His Asn Ser Arg His Asn Thr Arg His Asn Thr His Cys Ala 
        675                 680                 685             


Ser Ser Thr Ser Leu His Ala Leu Val Ala Asp Leu Arg Thr Glu Pro 
    690                 695                 700                 


Asn Met Leu Ile Pro Lys Ile Ile Gln Ser Arg Pro Pro Glu Arg Gly 
705                 710                 715                 720 


Tyr Asp Ala Leu Val Ile Asn Phe Ala Ile His Tyr Leu Cys Glu Thr 
                725                 730                 735     


Asp Asp Tyr Ile Arg Asn Phe Leu Ile Thr Val Ser Arg Leu Leu Ala 
            740                 745                 750         


His Asp Gly Val Phe Ile Phe Thr Thr Met Asp Gly Glu Ala Ile Val 
        755                 760                 765             


Asn Leu Leu Thr Glu His Lys Val Ala Pro Gly Ala Ser Trp Val Val 
    770                 775                 780                 


His Thr Asp Gly Asn Thr Asn Ala Thr Asp Ala Asn Val Val Lys Tyr 
785                 790                 795                 800 


Ser Ile Lys Arg Leu Tyr Asp Ser Asp Lys Leu Thr Lys Thr Gly Gln 
                805                 810                 815     


Lys Ile Ala Val Leu Leu Pro Met Ser Gly Glu Met Arg Glu Glu Pro 
            820                 825                 830         


Leu Cys Asn Ile Lys Asn Ile Val Ser Met Ala Arg Lys Met Gly Leu 
        835                 840                 845             


Asp Leu Val Glu Ser Ala Asn Phe Ser Val Leu Tyr Gly Ala Tyr Ala 
    850                 855                 860                 


Lys Asp Tyr Pro Glu Ile Tyr Ala Lys Leu Thr Pro Asp Asp Lys Leu 
865                 870                 875                 880 


Tyr Asn Asp Leu His Ala Phe Ala Val Phe Lys Arg Lys Lys 
                885                 890                 


<210>  10
<211>  901
<212>  PRT
<213>  Faustovirus


<220>
<221>  MISC_FEATURE
<223>  Faustovirus ST1 RNA capping enzyme; Genbank accession no. 
       SMH63629

<400>  10

Leu Glu Tyr Gln Tyr Tyr Lys Tyr Ile Leu Val Asn Ile Met Ser Arg 
1               5                   10                  15      


Arg Leu Gln Arg Cys Arg Asp Val Asp Gln Val Cys Glu Tyr Tyr Asn 
            20                  25                  30          


Ala Lys Gly Ala Ile Gly Glu Leu Glu Leu Arg Phe Asp Lys Leu Thr 
        35                  40                  45              


Pro Asp Leu Phe Ala His Val Phe Asp Lys Leu Lys Pro Asp Gly Glu 
    50                  55                  60                  


Ile Ser Thr Thr Met Arg Val Ser Asn Ser Asp Gly Thr Ala Arg Glu 
65                  70                  75                  80  


Ile Thr Phe Gly Gly Gly Val Lys Thr Gly Glu Thr Phe Val Arg Lys 
                85                  90                  95      


Gln Asn Ile Cys Val Phe Asp Val Val Asp Ile Phe Ser Tyr Lys Val 
            100                 105                 110         


Ala Val Ser Thr Glu Glu Thr Leu Val Asp Lys Pro Ala Met Glu Lys 
        115                 120                 125             


Asp Ala Ser Val Arg Phe Lys Ile Arg Met Ser Val Glu Gly Ala Val 
    130                 135                 140                 


Pro Asn Trp Arg Ile Asp Leu Thr Ala Val Lys Thr Ala Glu Leu Gly 
145                 150                 155                 160 


Lys Ile Ala Gln His Thr Ala Ser Leu Val Leu Gln Thr Phe Pro Pro 
                165                 170                 175     


Asn Leu Leu Lys Met Ser Gly Ala Glu Val Ala Lys Leu Ala Asn Asn 
            180                 185                 190         


Ser Tyr Glu Leu Glu Leu Glu Tyr Ile Gly Lys Thr Pro Ala Thr Lys 
        195                 200                 205             


Glu Arg Val Asp Ala Ala Ala Lys Tyr Ala Val Asp Leu Leu Ala Gly 
    210                 215                 220                 


Ile Lys Asn Ala Asn Ser Ala Val Gly Ala Val Leu Gly Glu Ser Ile 
225                 230                 235                 240 


Ser Asp Ile Cys Arg Val Ala Lys Val Ile His Thr Pro Asp Tyr Ala 
                245                 250                 255     


Thr Val Val Cys Arg Asn Pro Ser Phe Lys Met Leu Leu Pro Gln Val 
            260                 265                 270         


Ile Ser Leu Thr Lys Ser Ser Tyr Tyr Gly Gly Ile Tyr Pro Pro Glu 
        275                 280                 285             


Gly Met Tyr Val Ala Gly Lys Thr Asp Gly Val Arg Ala Leu Val Leu 
    290                 295                 300                 


Cys Glu Asp Gly Val Ala Lys Val Ile Thr Ala Glu Ser Val Asp Ile 
305                 310                 315                 320 


Thr Thr Gly Thr Cys Thr Gly Thr Thr Ile Leu Asp Cys Glu Leu Ser 
                325                 330                 335     


Thr Gly Lys Ser Gly Ala Thr Leu His Val Phe Asp Ile Ile Met His 
            340                 345                 350         


Asn Ser Lys Pro Ile His Ser Gln Pro Phe Ser Thr Arg Ile Ala Thr 
        355                 360                 365             


Asp Ile Ser Asp Val Lys Ile Pro Glu Tyr Lys Ile Ala Ile Lys Pro 
    370                 375                 380                 


Phe Val Lys Ile Gln Ala Thr Ala Leu Glu Ala Ala Phe Lys Glu Val 
385                 390                 395                 400 


Tyr Lys Ala Pro His Asn Glu Gly Leu Ile Leu Ile Met Asp Gly Asn 
                405                 410                 415     


Asp Tyr Ala Met Thr Lys Thr Tyr Lys Trp Lys Pro Leu Ser His Asn 
            420                 425                 430         


Thr Ile Asp Phe Leu Ile Lys Ala Cys Pro Lys Gln Leu Leu Asn Ile 
        435                 440                 445             


Asp Pro Tyr Lys Pro Arg Pro Gly His Lys Leu Trp Leu Leu Phe Thr 
    450                 455                 460                 


Thr Ile Ser Leu Asp Gln Gln Arg Glu Leu Gly Ile Glu Phe Ile Pro 
465                 470                 475                 480 


Ala Trp Lys Met Leu Phe Thr Asp Ile Asn Leu Phe Gly Ser Arg Val 
                485                 490                 495     


Pro Ile Gln Phe Met Pro Ala Ile Asn Pro Leu Ala Tyr Ile Cys Tyr 
            500                 505                 510         


Leu Pro Glu Ala Ala Thr Cys Ala Asn Gly Asp Ala Ile Asn Asp Gly 
        515                 520                 525             


Asp Ile Val Glu Met Arg Ala Val Asp Gly Phe Asp Thr Val Pro Lys 
    530                 535                 540                 


Trp Glu Pro Ile Arg Val Arg Ser Asp Arg Lys Asp Glu Pro Gly Phe 
545                 550                 555                 560 


Tyr Gly Asn Asn Tyr Lys Ile Ala Ser Asp Ile Tyr Leu Asn Tyr Ile 
                565                 570                 575     


Asp Ile Phe Gln Phe Glu Asp Leu Tyr Lys Tyr Asn Pro Gly Tyr Phe 
            580                 585                 590         


Glu Lys Asn Lys Ser Asp Ile Tyr Val Ala Pro Asn Lys Tyr Arg Arg 
        595                 600                 605             


Phe Leu Ile Lys Asn Ile Phe Ser Lys Tyr Leu Lys Asn Ala Lys Trp 
    610                 615                 620                 


Val Ile Asp Ala Ala Ala Gly Arg Gly Ala Asp Leu His Leu Tyr Lys 
625                 630                 635                 640 


Ala Glu Cys Val Glu Asn Leu Leu Ala Ile Asp Ile Asp Pro Thr Ala 
                645                 650                 655     


Ile Ser Glu Leu Val Arg Arg Arg Asn Glu Ile Thr Gly Tyr Asn Arg 
            660                 665                 670         


Gly His Arg Gly His Arg Gly Gly Ser Met Arg Ala His Met Gly Ala 
        675                 680                 685             


Ser His His Gly Ala Gln Asn Cys Ala Lys Ser Thr Thr Leu His Ala 
    690                 695                 700                 


Leu Val Ala Asp Leu Arg Thr Asp Pro Asp Val Leu Ile Pro Lys Ile 
705                 710                 715                 720 


Ile Gln Ser Arg Pro Pro Glu Arg Gly Tyr Asp Ala Ile Val Ile Asn 
                725                 730                 735     


Phe Ala Ile His Tyr Leu Cys Asp Thr Asp Glu His Ile Arg Asp Phe 
            740                 745                 750         


Leu Ile Thr Val Ser Arg Leu Leu Ala Pro Asn Gly Ile Phe Met Phe 
        755                 760                 765             


Thr Thr Met Asp Gly Glu Ser Ile Val Lys Leu Leu Glu Thr His Lys 
    770                 775                 780                 


Val Lys Ser Gly Glu Ser Trp Thr Val His Thr Gly Ala Asp Asp Pro 
785                 790                 795                 800 


Glu Ala Gly Val Ile Lys Tyr Ser Ile Arg Arg Leu Tyr Asp Ser Asp 
                805                 810                 815     


Lys Leu Thr Lys Thr Gly Gln Gln Ile Ala Val Leu Leu Pro Met Ser 
            820                 825                 830         


Gly Glu Met Lys Thr Glu Pro Leu Cys Asn Ile Lys Asn Ile Ile Ser 
        835                 840                 845             


Ile Ala Arg Lys Met Gly Leu Asp Leu Val Glu Ser Ala Asp Phe Ser 
    850                 855                 860                 


Val Met Tyr Asp Ala Phe Ala Arg Ala Tyr Pro Glu Ile Ser Ala Arg 
865                 870                 875                 880 


Leu Thr Pro Asp Asp Lys Leu Tyr Asn Asp Leu His Ser Tyr Ala Val 
                885                 890                 895     


Phe Lys Arg Lys Lys 
            900     


<210>  11
<211>  1170
<212>  PRT
<213>  Acanthamoeba polyphaga


<220>
<221>  MISC_FEATURE
<223>  mimivirus RNA capping enzyme; Genbank accession no. AAV50651

<400>  11

Met Gly Thr Lys Leu Lys Lys Ser Asn Asn Asp Ile Thr Ile Phe Ser 
1               5                   10                  15      


Glu Asn Glu Tyr Asn Glu Ile Val Glu Met Leu Arg Asp Tyr Ser Asn 
            20                  25                  30          


Gly Asp Asn Leu Glu Phe Glu Val Ser Phe Lys Asn Ile Asn Tyr Pro 
        35                  40                  45              


Asn Phe Met Arg Ile Thr Glu His Tyr Ile Asn Ile Thr Pro Glu Asn 
    50                  55                  60                  


Lys Ile Glu Ser Asn Asn Tyr Leu Asp Ile Ser Leu Ile Phe Pro Asp 
65                  70                  75                  80  


Lys Asn Val Tyr Arg Val Ser Leu Phe Asn Gln Glu Gln Ile Gly Glu 
                85                  90                  95      


Phe Ile Thr Lys Phe Ser Lys Ala Ser Ser Asn Asp Ile Ser Arg Tyr 
            100                 105                 110         


Ile Val Ser Leu Asp Pro Ser Asp Asp Ile Glu Ile Val Tyr Lys Asn 
        115                 120                 125             


Arg Gly Ser Gly Lys Leu Ile Gly Ile Asp Asn Trp Ala Ile Thr Ile 
    130                 135                 140                 


Lys Ser Thr Glu Glu Ile Pro Leu Val Ala Gly Lys Ser Lys Ile Ser 
145                 150                 155                 160 


Lys Pro Lys Ile Thr Gly Ser Glu Arg Ile Met Tyr Arg Tyr Lys Thr 
                165                 170                 175     


Arg Tyr Ser Phe Thr Ile Asn Lys Asn Ser Arg Ile Asp Ile Thr Asp 
            180                 185                 190         


Val Lys Ser Ser Pro Ile Ile Trp Lys Leu Met Thr Val Pro Ser Asn 
        195                 200                 205             


Tyr Glu Leu Glu Leu Glu Leu Ile Asn Lys Ile Asp Ile Asn Thr Leu 
    210                 215                 220                 


Glu Ser Glu Leu Leu Asn Val Phe Met Ile Ile Gln Asp Thr Lys Ile 
225                 230                 235                 240 


Pro Ile Ser Lys Ala Glu Ser Asp Thr Val Val Glu Glu Tyr Arg Asn 
                245                 250                 255     


Leu Leu Asn Val Arg Gln Thr Asn Asn Leu Asp Ser Arg Asn Val Ile 
            260                 265                 270         


Ser Val Asn Ser Asn His Ile Ile Asn Phe Ile Pro Asn Arg Tyr Ala 
        275                 280                 285             


Val Thr Asp Lys Ala Asp Gly Glu Arg Tyr Phe Leu Phe Ser Leu Asn 
    290                 295                 300                 


Ser Gly Ile Tyr Leu Leu Ser Ile Asn Leu Thr Val Lys Lys Leu Asn 
305                 310                 315                 320 


Ile Pro Val Leu Glu Lys Arg Tyr Gln Asn Met Leu Ile Asp Gly Glu 
                325                 330                 335     


Tyr Ile Lys Thr Thr Gly His Asp Leu Phe Met Val Phe Asp Val Ile 
            340                 345                 350         


Phe Ala Glu Gly Thr Asp Tyr Arg Tyr Asp Asn Thr Tyr Ser Leu Pro 
        355                 360                 365             


Lys Arg Ile Ile Ile Ile Asn Asn Ile Ile Asp Lys Cys Phe Gly Asn 
    370                 375                 380                 


Leu Ile Pro Phe Asn Asp Tyr Thr Asp Lys His Asn Asn Leu Glu Leu 
385                 390                 395                 400 


Asp Ser Ile Lys Thr Tyr Tyr Lys Ser Glu Leu Ser Asn Tyr Trp Lys 
                405                 410                 415     


Asn Phe Lys Asn Arg Leu Asn Lys Ser Thr Asp Leu Phe Ile Thr Arg 
            420                 425                 430         


Lys Leu Tyr Leu Val Pro Tyr Gly Ile Asp Ser Ser Glu Ile Phe Met 
        435                 440                 445             


Tyr Ala Asp Met Ile Trp Lys Leu Tyr Val Tyr Asn Glu Leu Thr Pro 
    450                 455                 460                 


Tyr Gln Leu Asp Gly Ile Ile Tyr Thr Pro Ile Asn Ser Pro Tyr Leu 
465                 470                 475                 480 


Ile Arg Gly Gly Ile Asp Ala Tyr Asp Thr Ile Pro Met Glu Tyr Lys 
                485                 490                 495     


Trp Lys Pro Pro Ser Gln Asn Ser Ile Asp Phe Tyr Ile Arg Phe Lys 
            500                 505                 510         


Lys Asp Val Ser Gly Ala Asp Ala Val Tyr Tyr Asp Asn Ser Val Glu 
        515                 520                 525             


Arg Ala Glu Gly Lys Pro Tyr Lys Ile Cys Leu Leu Tyr Val Gly Leu 
    530                 535                 540                 


Asn Lys Gln Gly Gln Glu Ile Pro Ile Gln Phe Lys Val Asn Gly Val 
545                 550                 555                 560 


Glu Gln Thr Ala Asn Ile Tyr Thr Lys Asp Gly Glu Ala Thr Asp Ile 
                565                 570                 575     


Asn Gly Asn Ala Ile Asn Asp Asn Thr Val Val Glu Phe Val Phe Asp 
            580                 585                 590         


Thr Leu Lys Ile Asp Met Asp Asp Ser Tyr Lys Trp Ile Pro Ile Arg 
        595                 600                 605             


Thr Arg Tyr Asp Lys Thr Glu Ser Val Gln Lys Tyr His Lys Arg Tyr 
    610                 615                 620                 


Gly Asn Asn Leu Gln Ile Ala Asn Arg Ile Trp Lys Thr Ile Thr Asn 
625                 630                 635                 640 


Pro Ile Thr Glu Asp Ile Ile Ser Ser Leu Gly Asp Pro Thr Thr Phe 
                645                 650                 655     


Asn Lys Glu Ile Thr Leu Leu Ser Asp Phe Arg Asp Thr Lys Tyr Asn 
            660                 665                 670         


Lys Gln Ala Leu Thr Tyr Tyr Gln Lys Asn Thr Ser Asn Ala Ala Gly 
        675                 680                 685             


Met Arg Ala Phe Asn Asn Trp Ile Lys Ser Asn Met Ile Thr Thr Tyr 
    690                 695                 700                 


Cys Arg Asp Gly Ser Lys Val Leu Asp Ile Gly Cys Gly Arg Gly Gly 
705                 710                 715                 720 


Asp Leu Ile Lys Phe Ile Asn Ala Gly Val Glu Phe Tyr Val Gly Ile 
                725                 730                 735     


Asp Ile Asp Asn Asn Gly Leu Tyr Val Ile Asn Asp Ser Ala Asn Asn 
            740                 745                 750         


Arg Tyr Lys Asn Leu Lys Lys Thr Ile Gln Asn Ile Pro Pro Met Tyr 
        755                 760                 765             


Phe Ile Asn Ala Asp Ala Arg Gly Leu Phe Thr Leu Glu Ala Gln Glu 
    770                 775                 780                 


Lys Ile Leu Pro Gly Met Pro Asp Phe Asn Lys Ser Leu Ile Asn Lys 
785                 790                 795                 800 


Tyr Leu Val Gly Asn Lys Tyr Asp Thr Ile Asn Cys Gln Phe Thr Ile 
                805                 810                 815     


His Tyr Tyr Leu Ser Asp Glu Leu Ser Trp Asn Asn Phe Cys Lys Asn 
            820                 825                 830         


Ile Asn Asn Gln Leu Lys Asp Asn Gly Tyr Leu Leu Ile Thr Ser Phe 
        835                 840                 845             


Asp Gly Asn Leu Ile His Asn Lys Leu Lys Gly Lys Gln Lys Leu Ser 
    850                 855                 860                 


Ser Ser Tyr Thr Asp Asn Arg Gly Asn Lys Asn Ile Phe Phe Glu Ile 
865                 870                 875                 880 


Asn Lys Ile Tyr Ser Asp Thr Asp Lys Val Gly Leu Gly Met Ala Ile 
                885                 890                 895     


Asp Leu Tyr Asn Ser Leu Ile Ser Asn Pro Gly Thr Tyr Ile Arg Glu 
            900                 905                 910         


Tyr Leu Val Phe Pro Glu Phe Leu Glu Lys Ser Leu Lys Glu Lys Cys 
        915                 920                 925             


Gly Leu Glu Leu Val Glu Ser Asp Leu Phe Tyr Asn Ile Phe Asn Thr 
    930                 935                 940                 


Tyr Lys Asn Tyr Phe Lys Lys Thr Tyr Asn Glu Tyr Gly Met Thr Asp 
945                 950                 955                 960 


Val Ser Ser Lys Lys His Ser Glu Ile Arg Glu Phe Tyr Leu Ser Leu 
                965                 970                 975     


Glu Gly Asn Ala Asn Asn Asp Ile Glu Ile Asp Ile Ala Arg Ala Ser 
            980                 985                 990         


Phe Lys Leu Ala Met Leu Asn Arg  Tyr Tyr Val Phe Arg  Lys Thr Ser 
        995                 1000                 1005             


Thr Ile  Asn Ile Thr Glu Pro  Ser Arg Ile Val Asn  Glu Leu Asn 
    1010                 1015                 1020             


Asn Arg  Ile Asp Leu Gly Lys  Phe Ile Met Pro Tyr  Phe Arg Thr 
    1025                 1030                 1035             


Asn Asn  Met Phe Ile Asp Leu  Asp Asn Val Asp Thr  Asp Ile Asn 
    1040                 1045                 1050             


Arg Val  Tyr Arg Asn Ile Arg  Asn Lys Tyr Arg Thr  Thr Arg Pro 
    1055                 1060                 1065             


His Val  Tyr Leu Ile Lys His  Asn Ile Asn Glu Asn  Arg Leu Glu 
    1070                 1075                 1080             


Asp Ile  Tyr Leu Ser Asn Asn  Lys Leu Asp Phe Ser  Lys Ile Lys 
    1085                 1090                 1095             


Asn Gly  Ser Asp Pro Lys Val  Leu Leu Ile Tyr Lys  Ser Pro Asp 
    1100                 1105                 1110             


Lys Gln  Phe Tyr Pro Leu Tyr  Tyr Gln Asn Tyr Gln  Ser Met Pro 
    1115                 1120                 1125             


Phe Asp  Leu Asp Gln Ile Tyr  Leu Pro Asp Lys Lys  Lys Tyr Leu 
    1130                 1135                 1140             


Leu Asp  Ser Asp Arg Ile Ile  Asn Asp Leu Asn Ile  Leu Ile Asn 
    1145                 1150                 1155             


Leu Thr  Glu Lys Ile Lys Asn  Ile Pro Gln Leu Ser  
    1160                 1165                 1170 


<210>  12
<211>  1162
<212>  PRT
<213>  Acanthamoeba polyphaga


<220>
<221>  misc_feature
<223>  moumouvirus RNA capping enzyme; Genbank accession no. 
       YP_007354410

<400>  12

Met Val Thr Lys Asn Lys Ser Glu Asn Ile Arg Asp Ile Leu Gly Ser 
1               5                   10                  15      


Asp Asn Val Ser Arg Val Glu Glu Met Ile Asn Asn Phe Arg Lys Asn 
            20                  25                  30          


Arg Asn Thr Glu Phe Glu Ile Ser Val Arg Lys Ile Asn Tyr Ser Asn 
        35                  40                  45              


Tyr Ile Arg Ile Ser Glu Tyr Tyr Val Asn Thr Ser Ser Asp Ile Gln 
    50                  55                  60                  


Gln Val Thr Ser Leu Asp Ile Ser Ile Ile Leu Glu Asp Gly Asn Thr 
65                  70                  75                  80  


Tyr Arg Val Ser Phe Leu Asn Glu Asn Leu Ile Asn Asp Phe Leu Ser 
                85                  90                  95      


Lys Tyr Ser Asn Met Lys Tyr Gly Asp Ile Val Lys Tyr Ile Leu Ala 
            100                 105                 110         


Leu Asn Pro Asn Asp Asp Ile Glu Ile Ile Tyr Lys Asn Arg Gly Ser 
        115                 120                 125             


Ala Asp Arg Leu Ser Ile Glu Asp Leu Asn Leu Val Val Lys Leu Thr 
    130                 135                 140                 


Glu Glu Val Pro Val Leu Asn Asn Thr Thr Lys Pro Lys Leu Ser Gly 
145                 150                 155                 160 


Arg Glu Lys Ile Leu Tyr Arg Tyr Lys Asn Arg Tyr Ser Phe Ile Ile 
                165                 170                 175     


Asp Asp Ile Thr Arg Ile Asp Ile Thr Asp Val Lys Glu Thr Pro Asn 
            180                 185                 190         


Ile Trp Glu Leu Ser Arg Lys Ile Ser Asn Tyr Glu Ile Glu Leu Glu 
        195                 200                 205             


Phe Thr Asn Asn Lys Ile Lys Ser Asn Gln Val Phe Glu Lys Ile Phe 
    210                 215                 220                 


Asp Leu Leu Arg Ile Val Gln Asn Thr Glu Ile Pro Ile Gly Ile Arg 
225                 230                 235                 240 


Glu Ser Lys Gln Val Ile Thr Asp Tyr Gln Asn Leu Leu Asn Leu Arg 
                245                 250                 255     


Ser Ser Asn His Leu Asp Ser Arg Asn Val Val Ser Ile Glu Thr Gln 
            260                 265                 270         


His Ile Val Lys Phe Val Pro Asn Arg Tyr Ala Ile Thr Asp Lys Ala 
        275                 280                 285             


Asp Gly Glu Arg Tyr Phe Leu Phe Ser Thr Pro Asn Gly Val Tyr Leu 
    290                 295                 300                 


Leu Ser Thr Asn Leu Thr Val Lys Lys Val Asn Ile Pro Val Leu Gln 
305                 310                 315                 320 


Lys Asp Phe Gln Asn Met Leu Leu Asp Gly Glu Leu Ile Asp Ile Asp 
                325                 330                 335     


Gly Lys Glu Leu Phe Met Val Phe Asp Val Val Tyr His Asn Gly Ile 
            340                 345                 350         


Asp Tyr Arg Tyr Asp Thr Asn Tyr Thr Leu Thr His Arg Ile Ile Ile 
        355                 360                 365             


Ile Asn Asp Ile Ile Asp Lys Ala Phe Asn Asn Leu Ile Pro Phe Thr 
    370                 375                 380                 


Asp Tyr Thr Asp Lys Tyr Asn Asn Leu Glu Leu Asp Lys Ile Lys Glu 
385                 390                 395                 400 


Phe Tyr Ser Asn Glu Ile Lys Thr Tyr Trp Lys Asn Phe Ser Lys Lys 
                405                 410                 415     


Leu Lys Asn Tyr Ser Gly Leu Phe Ile Ser Arg Lys Leu Tyr Phe Val 
            420                 425                 430         


Pro Tyr Gly Ile Asp Ser Ser Glu Val Phe Met Tyr Ala Asp Leu Val 
        435                 440                 445             


Trp Lys Leu Cys Val Tyr Asp Gln Leu Thr Pro Tyr Lys Leu Asp Gly 
    450                 455                 460                 


Ile Ile Tyr Thr Pro Ile Ala Ser Pro Tyr Met Ile Lys Thr Ser Ala 
465                 470                 475                 480 


Asn Glu Leu Asp Ser Val Pro Met Glu Tyr Lys Trp Lys Pro Pro Ser 
                485                 490                 495     


Gln Asn Ser Ile Asp Phe Tyr Val Lys Phe Asp Lys Asp Ala Arg Gly 
            500                 505                 510         


Asn Glu Ala Ile Tyr Tyr Asp Asn Ala Val Val Arg Gly Glu Gly Arg 
        515                 520                 525             


Pro Tyr Lys Val Cys Gly Leu Phe Val Gly Leu Asn Lys Gly Gly Glu 
    530                 535                 540                 


Glu Lys Pro Ile Ala Phe Lys Val Ala Gly Val Glu Gln Lys Ala Phe 
545                 550                 555                 560 


Ile Tyr Leu Thr Asn Asp Glu Ala Leu Asp Leu Ser Gly Asn Val Ile 
                565                 570                 575     


Asn Asp Asn Thr Val Val Glu Phe Ile Phe Asp Asn Phe Lys Thr Asp 
            580                 585                 590         


Met Asp Asp Pro Tyr Lys Trp Ile Pro Val Arg Thr Arg Tyr Asp Lys 
        595                 600                 605             


Thr Glu Ser Val Gln Lys Tyr Arg Lys Lys Tyr Gly Asn Asn Leu His 
    610                 615                 620                 


Ile Ala Thr Arg Ile Trp Arg Thr Ile Thr Asn Pro Val Thr Glu Glu 
625                 630                 635                 640 


Ile Ile Ala Ala Leu Gly Asn Ala Ser Thr Phe Glu Lys Glu Met Ser 
                645                 650                 655     


Lys Leu Val Lys Met Asn Glu Ser Tyr Asn Lys Gln Ser Phe Ser Tyr 
            660                 665                 670         


Tyr Gln Lys Asn Thr Ser Asn Ala Ile Gly Met Arg Ala Phe Asn Asn 
        675                 680                 685             


Phe Ile Lys Ser Asn Met Ile Thr Thr Tyr Cys Lys Asp Lys Asp Ser 
    690                 695                 700                 


Val Leu Asp Ile Gly Cys Gly Arg Gly Gly Asp Leu Ile Lys Phe Ile 
705                 710                 715                 720 


His Ala Asn Ile Arg Glu Tyr Val Gly Leu Asp Ile Asp Asn Asn Gly 
                725                 730                 735     


Leu Tyr Val Ile Asn Asp Ser Ala Phe Asn Arg Tyr Lys Asn Leu Lys 
            740                 745                 750         


Lys Thr Asn Lys Asn Val Pro Pro Met Thr Phe Ile Asn Ala Asp Ala 
        755                 760                 765             


Arg Gly Leu Phe Asn Val Glu Ala Gln Glu Lys Ile Leu Pro Asn Met 
    770                 775                 780                 


Ser Glu Ser Asn Lys Lys Leu Ile Asn Asn Tyr Leu Ser Ser Asn Lys 
785                 790                 795                 800 


Lys Tyr Asp Ala Ile Asn Cys Gln Phe Thr Ile His Tyr Tyr Leu Ser 
                805                 810                 815     


Asp Asp Ile Ser Trp Asn Asn Phe Cys Gln Asn Ile Asn Asn His Ile 
            820                 825                 830         


Lys Asp Asn Gly Tyr Leu Leu Ile Thr Cys Phe Asp Gly Gln Leu Ile 
        835                 840                 845             


Tyr Asp Lys Leu Lys Gly Lys Gln Lys Tyr Ser Ser Ser Tyr Thr Asp 
    850                 855                 860                 


Asn Phe Gly Lys Lys Asn Ile Phe Phe Glu Ile Asn Lys Ile Tyr Ser 
865                 870                 875                 880 


Asp Glu Glu Ile Lys Pro Val Gly Met Ala Ile Asp Ile Tyr Asn Ser 
                885                 890                 895     


Leu Ile Ser Asn Pro Gly Thr Tyr Gln Arg Glu Tyr Leu Val Phe Pro 
            900                 905                 910         


Asp Phe Leu Gln Lys Ser Leu Lys Asp Gln Cys Gly Leu Glu Leu Val 
        915                 920                 925             


Glu Thr Asp Met Phe Tyr Asn Ile Phe Asn Leu Tyr Arg Asn Tyr Phe 
    930                 935                 940                 


Thr Ile Asn Asn Gly Thr Phe Ser Thr Gly Glu Ile Ser Ser Lys Arg 
945                 950                 955                 960 


Tyr Asn Glu Ile Lys Asp Phe Tyr Leu Ala Leu Glu Gly Lys Ser Ser 
                965                 970                 975     


Ser Val Thr Glu Ser Asp Ile Ala Phe Ala Ser Phe Lys Leu Ala Met 
            980                 985                 990         


Leu Asn Arg Tyr Tyr Ile Phe Lys  Lys Lys Thr Val Ile  Asn Ile Thr 
        995                 1000                 1005             


Glu Pro  Ser His Ile Val Ser  Gly Val Asn Lys Lys  Thr Asp Leu 
    1010                 1015                 1020             


Gly Lys  Val Leu Met Pro Tyr  Phe Ile Thr Asn Asn  Met Ile Ile 
    1025                 1030                 1035             


Asp Tyr  Ser Leu Gly Asn Asn  Asp Val Asn Lys Ile  Tyr His Phe 
    1040                 1045                 1050             


Ile Arg  Lys Lys Tyr Ser Pro  Ile Lys Pro Ser Val  Tyr Leu Val 
    1055                 1060                 1065             


Arg His  Asn Ile Ile Asp Asn  Pro Met Asp Gly Ile  Thr Phe Ser 
    1070                 1075                 1080             


Arg Asn  Lys Leu Glu Phe Ile  Lys Ile Lys Asn Gly  Thr Asp Pro 
    1085                 1090                 1095             


Lys Val  Leu Leu Ile Tyr Lys  Ser Pro Glu Lys Ile  Phe Tyr Pro 
    1100                 1105                 1110             


Phe Tyr  Tyr Gln Arg Leu Glu  Asn His Asp Tyr Ser  Glu Asp Tyr 
    1115                 1120                 1125             


Leu Lys  Asn Asn Ile Tyr Leu  Lys Asp Asn Gly Thr  Tyr Leu Leu 
    1130                 1135                 1140             


Asp Ser  Asn Lys Ile Ile Asn  Asp Leu Asn Met Leu  Val Asn Ile 
    1145                 1150                 1155             


Ser Gly  Lys Val 
    1160         


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  RNA1

<400>  13
guagaacuuc gucgaguacg cucaa                                             25


<210>  14
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  RNA2

<400>  14
gcaagucuuc gucgaguacu ugc                                               23


<210>  15
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  RNA3

<400>  15
ggcaagucuu cgucgaguac uugc                                              24


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  RNA4

<400>  16
gggcaagucu ucgucgagua cuugc                                             25


<210>  17
<211>  150
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gggagucuuc gccgagaggg ccaucgccag uugccgcaac cugugggaau uucucuucca       60

guuuauccgg augcucaacg gugacuuuaa uuccgguauc uuucucgaau uucuuaccga      120

cuucagcgag cucgacaaug cucuucccua                                       150


<210>  18
<211>  1753
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  Sequence of the fluc transcript

<400>  18
gggucuagaa auaauuuugu uuaacuuuaa gaaggagaua uaaccaugaa aaucgaagaa       60

gguaaagguc accaucacca ucaccacgga uccauggaag acgccaaaaa cauaaagaaa      120

ggcccggcgc cauucuaucc ucuagaggau ggaaccgcug gagagcaacu gcauaaggcu      180

augaagagau acgcccuggu uccuggaaca auugcuuuua cagaugcaca uaucgaggug      240

aacaucacgu acgcggaaua cuucgaaaug uccguucggu uggcagaagc uaugaaacga      300

uaugggcuga auacaaauca cagaaucguc guaugcagug aaaacucucu ucaauucuuu      360

augccggugu ugggcgcguu auuuaucgga guugcaguug cgcccgcgaa cgacauuuau      420

aaugaacgug aauugcucaa caguaugaac auuucgcagc cuaccguagu guuuguuucc      480

aaaaaggggu ugcaaaaaau uuugaacgug caaaaaaaau uaccaauaau ccagaaaauu      540

auuaucaugg auucuaaaac ggauuaccag ggauuucagu cgauguacac guucgucaca      600

ucucaucuac cucccgguuu uaaugaauac gauuuuguac cagaguccuu ugaucgugac      660

aaaacaauug cacugauaau gaauuccucu ggaucuacug gguuaccuaa ggguguggcc      720

cuuccgcaua gaacugccug cgucagauuc ucgcaugcca gagauccuau uuuuggcaau      780

caaaucauuc cggauacugc gauuuuaagu guuguuccau uccaucacgg uuuuggaaug      840

uuuacuacac ucggauauuu gauaugugga uuucgagucg ucuuaaugua uagauuugaa      900

gaagagcugu uuuuacgauc ccuucaggau uacaaaauuc aaagugcguu gcuaguacca      960

acccuauuuu cauucuucgc caaaagcacu cugauugaca aauacgauuu aucuaauuua     1020

cacgaaauug cuucuggggg cgcaccucuu ucgaaagaag ucggggaagc gguugcaaaa     1080

cgcuuccauc uuccagggau acgacaagga uaugggcuca cugagacuac aucagcuauu     1140

cugauuacac ccgaggggga ugauaaaccg ggcgcggucg guaaaguugu uccauuuuuu     1200

gaagcgaagg uuguggaucu ggauaccggg aaaacgcugg gcguuaauca gagaggcgaa     1260

uuauguguca gaggaccuau gauuaugucc gguuauguaa acaauccgga agcgaccaac     1320

gccuugauug acaaggaugg auggcuacau ucuggagaca uagcuuacug ggacgaagac     1380

gaacacuucu ucauaguuga ccgcuugaag ucuuuaauua aauacaaagg auaucaggug     1440

gcccccgcug aauuggaauc gauauuguua caacacccca acaucuucga cgcgggcgug     1500

gcaggucuuc ccgacgauga cgccggugaa cuucccgccg ccguuguugu uuuggagcac     1560

ggaaagacga ugacggaaaa agagaucgug gauuacgucg ccagucaagu aacaaccgcg     1620

aaaaaguugc gcggaggagu uguguuugug gacgaaguac cgaaaggucu uaccggaaaa     1680

cucgacgcaa gaaaaaucag agagauccuc auaaaggcca agaagggcgg aaaguccaaa     1740

cucgaguaag guu                                                        1753


<210>  19
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  Targeting oligo for fluc transcript

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  C is TEG-desthiobiotin

<400>  19
gttaaarcra rarararuru rarurururc rurargrarc rcrc                        44


<210>  20
<211>  1778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<223>  The amino acid sequence of H3C2:T7 RNA polymerase fusion protein

<400>  20

Met Lys Ile Glu Glu His His His His His His His His Gly Ala Ser 
1               5                   10                  15      


Thr Ala Lys Arg Leu Gln Arg Cys Gln Asp Val Asn Gln Val Cys Glu 
            20                  25                  30          


Ile Tyr Asn Ser Lys Gly Gly Ile Gly Glu Leu Glu Leu Arg Phe Asp 
        35                  40                  45              


Lys Leu Pro Gln Asn Leu Phe Ala Gly Val Phe Asp Lys Leu Lys Pro 
    50                  55                  60                  


Asp Gly Glu Ile Gln Thr Thr Met Arg Val Ser Asn Arg Asp Gly Val 
65                  70                  75                  80  


Ala Arg Glu Ile Thr Phe Gly Gly Gly Val Lys Thr Asn Glu Ile Phe 
                85                  90                  95      


Val Lys Lys Gln Asn Ile Cys Val Phe Asp Val Val Asp Ile Phe Ser 
            100                 105                 110         


Tyr Lys Val Ala Val Ser Thr Glu Glu Thr Val Val Glu Lys Pro Thr 
        115                 120                 125             


Met Glu Thr Thr Ala Gly Val Arg Phe Lys Ile Arg Leu Ser Val Glu 
    130                 135                 140                 


Asp Val Val Lys Asp Trp Arg Ile Asp Leu Thr Ala Val Lys Thr Ala 
145                 150                 155                 160 


Glu Leu Gly Lys Ile Ala Gln His Thr Ala Ser Ile Val Gln Arg Thr 
                165                 170                 175     


Phe Pro Asp Asn Leu Leu Lys Leu Thr Gly Ala Glu Val Ala Lys Leu 
            180                 185                 190         


Ala Ala Asp Ser Tyr Glu Leu Glu Leu Glu Tyr Thr Gly Lys Ser Pro 
        195                 200                 205             


Ala Thr Asn Glu Lys Val Asn Val Ala Ala Lys Tyr Ala Val Glu Leu 
    210                 215                 220                 


Leu Ser Ser Val Arg Asn Ala Asn Ser Thr Ala Ala Ala Ser Phe Gly 
225                 230                 235                 240 


Glu Ser Val Ser Asp Leu Cys Arg Val Ala Lys Ile Ile His Thr His 
                245                 250                 255     


Glu Tyr Ala Asn Val Val Cys Arg Thr Pro Ser Phe Lys Met Leu Leu 
            260                 265                 270         


Pro Gln Val Val Ser Leu Thr Lys Ser Ser Tyr Tyr Gly Gly Leu Tyr 
        275                 280                 285             


Pro Pro Glu Asn Leu Trp Leu Ala Gly Lys Thr Asp Gly Val Arg Ala 
    290                 295                 300                 


Leu Val Val Cys Glu Asp Gly Val Ala Lys Val Ile Thr Ala Glu Ser 
305                 310                 315                 320 


Val Asp Ile Thr His Gly Val Cys Ser Ala Thr Thr Ile Leu Asp Cys 
                325                 330                 335     


Glu Leu Asn Val Asp Ala Lys Ile Leu Tyr Val Phe Asp Val Ile Ile 
            340                 345                 350         


Ser Asn Asn Thr Gln Val Tyr Thr Gln Pro Phe Ser Thr Arg Ile Thr 
        355                 360                 365             


Thr Asp Ile Ser Asp Ile Lys Ile Asp Gly Tyr Lys Ile Glu Met Lys 
    370                 375                 380                 


Pro Phe Val Lys Val Val Lys Ala Asp Glu Ala Thr Phe Lys Ser Ala 
385                 390                 395                 400 


Tyr Lys Ala Pro His Asn Glu Gly Leu Ile Met Ile Glu Asp Gly Ala 
                405                 410                 415     


Ala Tyr Ala Ala Thr Lys Thr Tyr Lys Trp Lys Pro Leu Ser His Asn 
            420                 425                 430         


Thr Ile Asp Phe Leu Ile Lys Ala Cys Pro Lys Gln Leu Ile Asn Val 
        435                 440                 445             


Asp Pro Tyr Lys Pro Arg Ala Gly Tyr Lys Leu Trp Leu Leu Phe Thr 
    450                 455                 460                 


Thr Ile Ser Leu Asp Gln Gln Arg Glu Leu Gly Ile Glu Phe Ile Pro 
465                 470                 475                 480 


Ala Trp Lys Ile Leu Phe Thr Asp Ile Asn Met Phe Gly Ser Arg Val 
                485                 490                 495     


Pro Ile Gln Phe Gln Pro Ala Ile Asn Pro Leu Ala Tyr Val Cys Tyr 
            500                 505                 510         


Leu Pro Glu Asp Val Asn Val Asn Asp Gly Asp Ile Val Glu Met Arg 
        515                 520                 525             


Ala Val Asp Gly Tyr Asp Thr Ile Pro Lys Trp Glu Leu Val Arg Ser 
    530                 535                 540                 


Arg Asn Asp Arg Lys Asn Glu Pro Gly Phe Tyr Gly Asn Asn Tyr Lys 
545                 550                 555                 560 


Ile Ala Ser Asp Ile Tyr Leu Asn Tyr Ile Asp Val Phe His Phe Glu 
                565                 570                 575     


Asp Leu Tyr Lys Tyr Asn Pro Gly Tyr Phe Glu Lys Asn Lys Ser Asp 
            580                 585                 590         


Ile Tyr Val Ala Pro Asn Lys Tyr Arg Arg Tyr Leu Ile Lys Ser Leu 
        595                 600                 605             


Phe Gly Arg Tyr Leu Arg Asp Ala Lys Trp Val Ile Asp Ala Ala Ala 
    610                 615                 620                 


Gly Arg Gly Ala Asp Leu His Leu Tyr Lys Ala Glu Cys Val Glu His 
625                 630                 635                 640 


Leu Leu Ala Ile Asp Ile Asp Pro Thr Ala Ile Ser Glu Leu Val Arg 
                645                 650                 655     


Arg Arg Asn Glu Ile Thr Gly Tyr Asn Lys Ser His Arg Gly Gly Arg 
            660                 665                 670         


Asn Met His Ser His Arg Gly Gln Ser His Cys Ala Lys Ser Thr Ser 
        675                 680                 685             


Leu His Ala Leu Val Ala Asp Leu Arg Glu Asn Pro Asp Val Leu Ile 
    690                 695                 700                 


Pro Lys Ile Ile Gln Ser Arg Pro His Glu Arg Cys Tyr Asp Ala Ile 
705                 710                 715                 720 


Val Ile Asn Phe Ala Ile His Tyr Leu Cys Asp Thr Asp Glu His Ile 
                725                 730                 735     


Arg Asp Phe Leu Ile Thr Val Ser Arg Leu Leu Ala Pro Asn Gly Val 
            740                 745                 750         


Phe Ile Phe Thr Thr Met Asp Gly Glu Ser Ile Val Lys Leu Leu Ala 
        755                 760                 765             


Asp His Lys Val Arg Pro Gly Glu Ala Trp Thr Ile His Thr Gly Asp 
    770                 775                 780                 


Val Asn Ser Pro Asp Ser Thr Val Pro Lys Tyr Ser Ile Arg Arg Leu 
785                 790                 795                 800 


Tyr Asp Ser Asp Lys Leu Thr Lys Thr Gly Gln Gln Ile Glu Val Leu 
                805                 810                 815     


Leu Pro Met Ser Gly Glu Met Lys Ala Glu Pro Leu Cys Asn Ile Lys 
            820                 825                 830         


Asn Ile Ile Ser Met Ala Arg Lys Met Gly Leu Asp Leu Val Glu Ser 
        835                 840                 845             


Ala Asn Phe Ser Val Leu Tyr Glu Ala Tyr Ala Arg Asp Tyr Pro Asp 
    850                 855                 860                 


Ile Tyr Ala Arg Met Thr Pro Asp Asp Lys Leu Tyr Asn Asp Leu His 
865                 870                 875                 880 


Thr Tyr Ala Val Phe Lys Arg Lys Lys Gly Ala Ser Thr Ala Ser Thr 
                885                 890                 895     


Asn Thr Ile Asn Ile Ala Lys Asn Asp Phe Ser Asp Ile Glu Leu Ala 
            900                 905                 910         


Ala Ile Pro Phe Asn Thr Leu Ala Asp His Tyr Gly Glu Arg Leu Ala 
        915                 920                 925             


Arg Glu Gln Leu Ala Leu Glu His Glu Ser Tyr Glu Met Gly Glu Ala 
    930                 935                 940                 


Arg Phe Arg Lys Met Phe Glu Arg Gln Leu Lys Ala Gly Glu Val Ala 
945                 950                 955                 960 


Asp Asn Ala Ala Ala Lys Pro Leu Ile Thr Thr Leu Leu Pro Lys Met 
                965                 970                 975     


Ile Ala Arg Ile Asn Asp Trp Phe Glu Glu Val Lys Ala Lys Arg Gly 
            980                 985                 990         


Lys Arg Pro Thr Ala Phe Gln Phe  Leu Gln Glu Ile Lys  Pro Glu Ala 
        995                 1000                 1005             


Val Ala  Tyr Ile Thr Ile Lys  Thr Thr Leu Ala Cys  Leu Thr Ser 
    1010                 1015                 1020             


Ala Asp  Asn Thr Thr Val Gln  Ala Val Ala Ser Ala  Ile Gly Arg 
    1025                 1030                 1035             


Ala Ile  Glu Asp Glu Ala Arg  Phe Gly Arg Ile Arg  Asp Leu Glu 
    1040                 1045                 1050             


Ala Lys  His Phe Lys Lys Asn  Val Glu Glu Gln Leu  Asn Lys Arg 
    1055                 1060                 1065             


Val Gly  His Val Tyr Lys Lys  Ala Phe Met Gln Val  Val Glu Ala 
    1070                 1075                 1080             


Asp Met  Leu Ser Lys Gly Leu  Leu Gly Gly Glu Ala  Trp Ser Ser 
    1085                 1090                 1095             


Trp His  Lys Glu Asp Ser Ile  His Val Gly Val Arg  Cys Ile Glu 
    1100                 1105                 1110             


Met Leu  Ile Glu Ser Thr Gly  Met Val Ser Leu His  Arg Gln Asn 
    1115                 1120                 1125             


Ala Gly  Val Val Gly Gln Asp  Ser Glu Thr Ile Glu  Leu Ala Pro 
    1130                 1135                 1140             


Glu Tyr  Ala Glu Ala Ile Ala  Thr Arg Ala Gly Ala  Leu Ala Gly 
    1145                 1150                 1155             


Ile Ser  Pro Met Phe Gln Pro  Cys Val Val Pro Pro  Lys Pro Trp 
    1160                 1165                 1170             


Thr Gly  Ile Thr Gly Gly Gly  Tyr Trp Ala Asn Gly  Arg Arg Pro 
    1175                 1180                 1185             


Leu Ala  Leu Val Arg Thr His  Ser Lys Lys Ala Leu  Met Arg Tyr 
    1190                 1195                 1200             


Glu Asp  Val Tyr Met Pro Glu  Val Tyr Lys Ala Ile  Asn Ile Ala 
    1205                 1210                 1215             


Gln Asn  Thr Ala Trp Lys Ile  Asn Lys Lys Val Leu  Ala Val Ala 
    1220                 1225                 1230             


Asn Val  Ile Thr Lys Trp Lys  His Cys Pro Val Glu  Asp Ile Pro 
    1235                 1240                 1245             


Ala Ile  Glu Arg Glu Glu Leu  Pro Met Lys Pro Glu  Asp Ile Asp 
    1250                 1255                 1260             


Met Asn  Pro Glu Ala Leu Thr  Ala Trp Lys Arg Ala  Ala Ala Ala 
    1265                 1270                 1275             


Val Tyr  Arg Lys Asp Lys Ala  Arg Lys Ser Arg Arg  Ile Ser Leu 
    1280                 1285                 1290             


Glu Phe  Met Leu Glu Gln Ala  Asn Lys Phe Ala Asn  His Lys Ala 
    1295                 1300                 1305             


Ile Trp  Phe Pro Tyr Asn Met  Asp Trp Arg Gly Arg  Val Tyr Ala 
    1310                 1315                 1320             


Val Ser  Met Phe Asn Pro Gln  Gly Asn Asp Met Thr  Lys Gly Leu 
    1325                 1330                 1335             


Leu Thr  Leu Ala Lys Gly Lys  Pro Ile Gly Lys Glu  Gly Tyr Tyr 
    1340                 1345                 1350             


Trp Leu  Lys Ile His Gly Ala  Asn Cys Ala Gly Val  Asp Lys Val 
    1355                 1360                 1365             


Pro Phe  Pro Glu Arg Ile Lys  Phe Ile Glu Glu Asn  His Glu Asn 
    1370                 1375                 1380             


Ile Met  Ala Cys Ala Lys Ser  Pro Leu Glu Asn Thr  Trp Trp Ala 
    1385                 1390                 1395             


Glu Gln  Asp Ser Pro Phe Cys  Phe Leu Ala Phe Cys  Phe Glu Tyr 
    1400                 1405                 1410             


Ala Gly  Val Gln His His Gly  Leu Ser Tyr Asn Cys  Ser Leu Pro 
    1415                 1420                 1425             


Leu Ala  Phe Asp Gly Ser Cys  Ser Gly Ile Gln His  Phe Ser Ala 
    1430                 1435                 1440             


Met Leu  Arg Asp Glu Val Gly  Gly Arg Ala Val Asn  Leu Leu Pro 
    1445                 1450                 1455             


Ser Glu  Thr Val Gln Asp Ile  Tyr Gly Ile Val Ala  Lys Lys Val 
    1460                 1465                 1470             


Asn Glu  Ile Leu Gln Ala Asp  Ala Ile Asn Gly Thr  Asp Asn Glu 
    1475                 1480                 1485             


Val Val  Thr Val Thr Asp Glu  Asn Thr Gly Glu Ile  Ser Glu Lys 
    1490                 1495                 1500             


Val Lys  Leu Gly Thr Lys Ala  Leu Ala Gly Gln Trp  Leu Ala Tyr 
    1505                 1510                 1515             


Gly Val  Thr Arg Ser Val Thr  Lys Arg Ser Val Met  Thr Leu Ala 
    1520                 1525                 1530             


Tyr Gly  Ser Lys Glu Phe Gly  Phe Arg Gln Gln Val  Leu Glu Asp 
    1535                 1540                 1545             


Thr Ile  Gln Pro Ala Ile Asp  Ser Gly Lys Gly Leu  Met Phe Thr 
    1550                 1555                 1560             


Gln Pro  Asn Gln Ala Ala Gly  Tyr Met Ala Lys Leu  Ile Trp Glu 
    1565                 1570                 1575             


Ser Val  Ser Val Thr Val Val  Ala Ala Val Glu Ala  Met Asn Trp 
    1580                 1585                 1590             


Leu Lys  Ser Ala Ala Lys Leu  Leu Ala Ala Glu Val  Lys Asp Lys 
    1595                 1600                 1605             


Lys Thr  Gly Glu Ile Leu Arg  Lys Arg Cys Ala Val  His Trp Val 
    1610                 1615                 1620             


Thr Pro  Asp Gly Phe Pro Val  Trp Gln Glu Tyr Lys  Lys Pro Ile 
    1625                 1630                 1635             


Gln Thr  Arg Leu Asn Leu Met  Phe Leu Gly Gln Phe  Arg Leu Gln 
    1640                 1645                 1650             


Pro Thr  Ile Asn Thr Asn Lys  Asp Ser Glu Ile Asp  Ala His Lys 
    1655                 1660                 1665             


Gln Glu  Ser Gly Ile Ala Pro  Asn Phe Val His Ser  Gln Asp Gly 
    1670                 1675                 1680             


Ser His  Leu Arg Lys Thr Val  Val Trp Ala His Glu  Lys Tyr Gly 
    1685                 1690                 1695             


Ile Glu  Ser Phe Ala Leu Ile  His Asp Ser Phe Gly  Thr Ile Pro 
    1700                 1705                 1710             


Ala Asp  Ala Ala Asn Leu Phe  Lys Ala Val Arg Glu  Thr Met Val 
    1715                 1720                 1725             


Asp Thr  Tyr Glu Ser Cys Asp  Val Leu Ala Asp Phe  Tyr Asp Gln 
    1730                 1735                 1740             


Phe Ala  Asp Gln Leu His Glu  Ser Gln Leu Asp Lys  Met Pro Ala 
    1745                 1750                 1755             


Leu Pro  Ala Lys Gly Asn Leu  Asn Leu Arg Asp Ile  Leu Glu Ser 
    1760                 1765                 1770             


Asp Phe  Ala Phe Ala 
    1775             


<210>  21
<211>  5337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<223>  Nucleotide sequence of H3C2:T7 RNA polymerase fusion protein

<400>  21
atgaagattg aggagcatca tcatcatcat catcatcatg gcgcgagcac cgcgaagcgt       60

ctgcagcgtt gccaggacgt gaaccaagtg tgcgaaatct acaacagcaa gggtggcatt      120

ggcgagctgg aactgcgttt cgataaactg ccgcagaacc tgttcgcggg cgtttttgat      180

aagctgaaac cggacggcga gattcaaacc accatgcgtg ttagcaaccg tgacggtgtg      240

gcgcgtgaaa tcacctttgg tggcggtgtt aagaccaacg agatcttcgt gaagaaacag      300

aacatttgcg ttttcgacgt ggttgatatc tttagctaca aggtggcggt tagcaccgag      360

gaaaccgtgg ttgaaaagcc gaccatggag accaccgcgg gcgtgcgttt taaaattcgt      420

ctgagcgttg aagacgtggt taaggattgg cgtatcgatc tgaccgcggt gaagaccgcg      480

gagctgggta aaatcgcgca gcacaccgcg agcattgttc aacgtacctt cccggataac      540

ctgctgaagc tgaccggtgc ggaagtggcg aaactggcgg cggacagcta cgagctggaa      600

ctggagtata ccggcaagag cccggcgacc aacgaaaagg tgaacgttgc ggcgaaatac      660

gcggttgagc tgctgagcag cgtgcgtaac gcgaacagca ccgcggcggc gagctttggt      720

gaaagcgtta gcgacctgtg ccgtgtggcg aaaatcattc acacccacga gtacgcgaac      780

gtggtttgcc gtaccccgag cttcaaaatg ctgctgccgc aggtggttag cctgaccaag      840

agcagctact atggcggtct gtatccgccg gaaaacctgt ggctggcggg caagaccgat      900

ggcgtgcgtg cgctggttgt gtgcgaagac ggcgtggcga aagttatcac cgcggagagc      960

gttgatatta cccacggtgt gtgcagcgcg accaccattc tggattgcga gctgaacgtt     1020

gacgcgaaga tcctgtacgt gtttgacgtt atcattagca acaacaccca ggtgtatacc     1080

caaccgttca gcacccgtat caccaccgac attagcgata tcaagatcga tggttacaag     1140

atcgaaatga agccgtttgt taaggtggtt aaggcggacg aggcgacctt caagagcgcg     1200

tataaagcgc cgcacaacga aggcctgatc atgattgaag atggtgcggc gtacgcggcg     1260

accaagacct ataagtggaa accgctgagc cacaacacca tcgatttcct gattaaggcg     1320

tgcccgaaac agctgattaa cgtggacccg tacaagccgc gtgcgggtta taaactgtgg     1380

ctgctgttta ccaccatcag cctggatcag caacgtgaac tgggcatcga gttcattccg     1440

gcgtggaaaa tcctgttcac cgacattaac atgtttggta gccgtgtgcc gatccagttt     1500

caaccggcga ttaacccgct ggcgtacgtt tgctatctgc cggaagacgt gaacgttaac     1560

gacggcgata ttgttgagat gcgtgcggtg gacggttacg ataccatccc gaaatgggaa     1620

ctggttcgta gccgtaacga tcgtaagaac gagccgggtt tctacggcaa caactataaa     1680

atcgcgagcg acatttacct gaactatatt gatgttttcc actttgaaga cctgtacaaa     1740

tataacccgg gctacttcga gaagaacaag agcgatatct acgtggcgcc gaacaagtac     1800

cgtcgttatc tgatcaaaag cctgttcggt cgttacctgc gtgatgcgaa gtgggtgatt     1860

gatgcggcgg cgggtcgtgg cgcggacctg cacctgtata aagcggaatg cgttgagcac     1920

ctgctggcga tcgacattga tccgaccgcg atcagcgaac tggtgcgtcg tcgtaacgag     1980

attaccggct acaacaagag ccaccgtggc ggtcgtaaca tgcacagcca ccgtggtcag     2040

agccactgcg cgaaaagcac cagcctgcac gcgctggttg cggatctgcg tgaaaacccg     2100

gacgttctga ttccgaagat cattcaaagc cgtccgcacg agcgttgcta cgatgcgatc     2160

gttattaact ttgcgatcca ctatctgtgc gacaccgatg aacacatccg tgacttcctg     2220

attaccgtga gccgtctgct ggcgccgaac ggtgttttca tctttaccac catggatggt     2280

gaaagcattg tgaagctgct ggcggaccac aaagttcgtc cgggtgaagc gtggaccatc     2340

cacaccggtg atgtgaacag cccggacagc accgttccga aatacagcat tcgtcgtctg     2400

tatgacagcg ataagctgac caaaaccggc cagcaaatcg aggttctgct gccgatgagc     2460

ggtgaaatga aggcggagcc gctgtgcaac attaaaaaca tcattagcat ggcgcgtaag     2520

atgggtctgg atctggtgga aagcgcgaac tttagcgttc tgtacgaggc gtatgcgcgt     2580

gactacccgg atatctatgc gcgtatgacc ccggacgata agctgtacaa cgacctgcac     2640

acctatgcgg tgttcaagcg taagaaaggc gcgagcaccg cgagcaccaa caccatcaac     2700

attgcgaaga acgactttag cgatatcgag ctggcggcga ttccgttcaa caccctggcg     2760

gaccactacg gtgaacgtct ggcgcgtgag cagctggcgc tggaacacga gagctatgaa     2820

atgggcgagg cgcgtttccg taagatgttt gaacgtcaac tgaaagcggg tgaggttgcg     2880

gataacgcgg cggcgaaacc gctgattacc accctgctgc cgaagatgat cgcgcgtatt     2940

aacgactggt tcgaggaagt taaggcgaaa cgtggtaaac gtccgaccgc gttccagttt     3000

ctgcaagaaa tcaaaccgga ggcggtggcg tacatcacca ttaaaaccac cctggcgtgc     3060

ctgaccagcg cggacaacac caccgtgcag gcggttgcga gcgcgattgg tcgtgcgatt     3120

gaagatgagg cgcgttttgg tcgtatccgt gacctggaag cgaagcactt caagaaaaac     3180

gttgaggaac agctgaacaa acgtgtgggc cacgtttata agaaagcgtt catgcaagtg     3240

gttgaggcgg atatgctgag caagggtctg ctgggcggtg aagcgtggag cagctggcac     3300

aaagaggaca gcatccacgt gggcgttcgt tgcatcgaaa tgctgattga gagcaccggt     3360

atggttagcc tgcaccgtca gaacgcgggt gtggttggcc aagatagcga aaccatcgag     3420

ctggcgccgg aatacgcgga ggcgattgcg acccgtgcgg gtgcgctggc gggtatcagc     3480

ccgatgtttc aaccgtgcgt ggttccgccg aagccgtgga ccggtattac cggcggtggc     3540

tactgggcga acggtcgtcg tccgctggcg ctggtgcgta cccacagcaa gaaagcgctg     3600

atgcgttacg aagacgttta tatgccggaa gtgtataagg cgatcaacat tgcgcaaaac     3660

accgcgtgga aaattaacaa gaaagtgctg gcggttgcga acgtgatcac caagtggaaa     3720

cactgcccgg ttgaagatat cccggcgatt gagcgtgagg aactgccgat gaaaccggaa     3780

gacatcgata tgaacccgga agcgctgacc gcgtggaaac gtgcggcggc ggcggtgtac     3840

cgtaaggaca aagcgcgtaa aagccgtcgt attagcctgg aattcatgct ggagcaggcg     3900

aacaagtttg cgaaccacaa agcgatctgg ttcccgtaca acatggattg gcgtggccgt     3960

gtttatgctg tgagcatgtt caacccgcaa ggcaacgaca tgaccaaggg cctgctgacc     4020

ctggcgaagg gtaaaccgat tggcaaggaa ggctactatt ggctgaaaat ccacggtgcg     4080

aactgcgcgg gcgttgataa agtgccgttc ccggaacgta tcaagtttat tgaggaaaac     4140

cacgagaaca tcatggcgtg cgcgaaaagc ccgctggaaa acacctggtg ggcggagcag     4200

gacagcccgt tctgctttct ggcgttctgc tttgagtacg cgggtgttca acaccacggc     4260

ctgagctata actgcagcct gccgctggcg tttgatggta gctgcagcgg catccagcac     4320

ttcagcgcga tgctgcgtga cgaagttggt ggccgtgcgg tgaacctgct gccgagcgag     4380

accgtgcagg atatctacgg tattgttgcg aagaaagtga acgagatcct gcaagcggat     4440

gcgattaacg gcaccgacaa cgaagtggtt accgtgaccg acgagaacac cggtgaaatc     4500

agcgagaagg ttaaactggg taccaaagcg ctggcgggcc agtggctggc gtacggtgtt     4560

acccgtagcg tgaccaagcg tagcgttatg accctggcgt atggtagcaa agaattcggc     4620

tttcgtcagc aagtgctgga ggataccatc caaccggcga ttgacagcgg caagggcctg     4680

atgtttaccc agccgaacca agcggcgggt tacatggcga aactgatctg ggaaagcgtg     4740

agcgttaccg tggttgcggc ggttgaggcg atgaactggc tgaagagcgc ggcgaaactg     4800

ctggcggcgg aagtgaaaga taagaaaacc ggcgagattc tgcgtaagcg ttgcgcggtt     4860

cactgggtga ccccggacgg tttcccggtt tggcaggaat ataagaaacc gatccaaacc     4920

cgtctgaacc tgatgttcct gggccagttt cgtctgcaac cgaccatcaa caccaacaaa     4980

gatagcgaaa ttgacgcgca caagcaggag agcggcattg cgccgaactt tgtgcacagc     5040

caagacggta gccacctgcg taaaaccgtg gtttgggcgc acgaaaagta cggcatcgag     5100

agcttcgcgc tgattcacga tagctttggt accattccgg cggatgcggc gaacctgttc     5160

aaggcggttc gtgaaaccat ggtggatacc tacgagagct gcgacgtgct ggcggacttc     5220

tatgatcagt ttgcggatca actgcacgag agccagctgg acaaaatgcc ggcgctgccg     5280

gcgaagggta acctgaacct gcgtgacatt ctggagagcg attttgcgtt tgcgtaa        5337


