                         SEQUENCE LISTING

<110>  OBSIDIAN THERAPEUTICS, INC.
 
<120>  TANDEM CD19 CAR-BASED COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY

<130>  268052-454311

<160>  1236  

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  Escherichia coli

<400>  1

Met Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Arg Val Ile Gly Met 
1               5                   10                  15      


Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys 
            20                  25                  30          


Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu 
        35                  40                  45              


Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser 
    50                  55                  60                  


Gln Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu 
65                  70                  75                  80  


Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly 
                85                  90                  95      


Gly Arg Val Tyr Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu 
            100                 105                 110         


Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr 
        115                 120                 125             


Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp 
    130                 135                 140                 


Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155                 


<210>  2
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210>  3
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  4
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  4

Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu 
1               5                   10                  15      


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
            20                  25                  30          


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
        35                  40                  45              


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
    50                  55                  60                  


Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
65                  70                  75                  80  


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
                85                  90                  95      


Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
            100                 105                 110         


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu 
        115                 120                 125             


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
    130                 135                 140                 


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155             


<210>  5
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  5

Ile Ser Leu Ile Ala Ala Leu Ala Val Asp His Val Ile Gly Met Glu 
1               5                   10                  15      


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
            20                  25                  30          


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
        35                  40                  45              


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
    50                  55                  60                  


Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
65                  70                  75                  80  


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
                85                  90                  95      


Arg Val Tyr Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
            100                 105                 110         


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Lys 
        115                 120                 125             


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
    130                 135                 140                 


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155             


<210>  6
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  6

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Pro Glu 
            100                 105         


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  7

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
            100                 105         


<210>  8
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  8

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Phe Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  9
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  9

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  10
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  10

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  11
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  11

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Asn Tyr His Leu Glu Asn Glu Val Ala 
    130                 135                 140                 


Arg Leu Lys Lys Leu Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 


<210>  12
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  12

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Asn Tyr His Leu Glu Asn Glu Val Ala 
    130                 135                 140                 


Arg Leu Lys Lys Leu Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  13
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  13

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
                85                  90                  95      


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly Gly 
    210                 215                 220                 


Gly Gly Ser Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys 
225                 230                 235                 240 


Leu 
    


<210>  14
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  14

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
225                 230                 235                 240 


Lys Leu Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  15
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  15

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  16

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  17
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  17

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210>  18
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  18

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ser Asp Pro Leu Ile Asn Lys Glu Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135         


<210>  19
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Phe Tyr Ser Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  20
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  20

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ile Asp Tyr Gly Ser Gly Ser Tyr Ser Pro Arg Thr Ser 
            100                 105                 110         


Tyr Tyr Tyr Tyr Met Ser Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  21
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  22
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  23
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  23

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr 
225             


<210>  24
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain


<220>
<221>  MOD_RES
<222>  (64)..(65)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (68)..(69)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (93)..(93)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (98)..(98)
<223>  Any amino acid

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Xaa 
    50                  55                  60                  


Xaa Gly Arg Xaa Xaa Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa 
        


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain


<220>
<221>  MOD_RES
<222>  (76)..(76)
<223>  Any amino acid

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  28
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Lys Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  31

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  32

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn 
145                 150                 155                 160 


Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg 
225                 230                 235                 240 


Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu 
            260                 265                 270         


Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val 
305                 310                 315                 320 


Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile 
        355                 360                 365             


Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys 
    370                 375                 380                 


Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp 
385                 390                 395                 400 


Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp 
                405                 410                 415     


Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser 
            420                 425                 430         


Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460                 


<210>  33
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  33

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Trp Tyr Cys Ser Arg His 
                85                  90                  95      


Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215             


<210>  35
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ser Arg 
                85                  90                  95      


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 


<210>  36
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  36

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Asn Tyr His Leu Glu Asn Glu Val Ala 
    130                 135                 140                 


Arg Leu Lys Lys Leu Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
225                 230                 235                 240 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  37
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  37

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
225                 230                 235                 240 


Lys Leu 
        


<210>  38
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  38

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
    210                 215                 220                 


Gly Gly Gly Ser Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys 
225                 230                 235                 240 


Lys Leu Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  39
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  39

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val 
        115             


<210>  40
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic heavy chain 
       variable domain

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val 
        115                 


<210>  41
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  41

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Gln Ile Lys Arg 
            100                 105                 110         


<210>  42
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Arg Lys Gly Leu Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  43
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  43

Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Val Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Asp Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  44

Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Pro Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Lys Thr Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Ser Tyr Ile Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  45
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  45

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  46

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Gly Gly Gly Gly Ser Asn Tyr His 
                165                 170                 175     


Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Gly Gly Gly Gly Ser 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  47

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  48

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  49
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  49

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp 
        115 


<210>  50
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  50

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  51
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  51

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  52
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  52

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val 
        35                  40                  45              


Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser 
    50                  55                  60                  


Gly Arg Ala Ala Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  53
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  53

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val 
        35                  40                  45              


Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser 
    50                  55                  60                  


Gly Arg Ala Ala Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Phe Cys Ser Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  54
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  54

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Phe Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Ser Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  55
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  55

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Glu Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Asn Leu 
                85                  90                  95      


Ser Ala Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  56
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  56

Ser Tyr Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Asn 
                85                  90                  95      


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  57

Ala Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Ala Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Ala Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Thr Ile Arg 
            100                 105         


<210>  58
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  58

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg 
                85                  90                  95      


Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  59
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  59

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln 
                85                  90                  95      


Ala Tyr Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 


<210>  60
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  60

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Asn Arg Asp Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  61
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain


<220>
<221>  MOD_RES
<222>  (5)..(6)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (8)..(9)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (93)..(93)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (104)..(104)
<223>  Any amino acid

<400>  61

Gln Ser Val Leu Xaa Xaa Pro Xaa Xaa Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Thr Gly Thr Gly Arg Asp Ile Gly Ala Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Val Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Xaa Ala Gly Arg 
                85                  90                  95      


Lys Tyr Val Phe Gly Thr Gly Xaa Lys Val Thr Val Leu 
            100                 105                 


<210>  62
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain


<220>
<221>  MOD_RES
<222>  (61)..(61)
<223>  Any amino acid

<400>  62

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Glu Thr Ser Ser Asp Leu Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Val Arg Pro Ser Gly Val Xaa Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  63
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  63

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  64
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  64

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ala Lys Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly 
                85                  90                  95      


Pro Thr Phe Val Phe Gly Thr Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 110 


<210>  65
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  65

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 110         


<210>  66
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  66

Gln Ser Val Leu Thr Gln Pro Arg Ser Leu Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ala Cys Thr Gly Ala Ser Thr Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Thr Phe Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  67
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  67

Gln Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Phe Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp His Val Ser Trp Tyr Gln His His Pro Gly Lys Gly Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Tyr 
                85                  90                  95      


Tyr Thr Tyr Trp Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  68
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  68

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val 
        35                  40                  45              


Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser 
    50                  55                  60                  


Gly Arg Ala Ala Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Pro 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  69
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  69

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Val Val 
            


<210>  70
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  70

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Gly Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu 
                85                  90                  95      


Arg Phe Gly Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  71
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  71

Gln Ser Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Pro Ile Ser Gly Val Gly Asp Tyr 
            20                  25                  30          


Thr Ser Val Ser Trp Tyr Gln His Tyr Pro Gly Lys Thr Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Gln Arg Pro Ser Gly Val Pro Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Glu Ala Pro 
                85                  90                  95      


Thr His Thr Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  72
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  72

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  73
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  73

Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser 
        35                  40                  45              


Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  74
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  74

Gln Ala Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His 
            20                  25                  30          


Arg Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Ala Ile 
                85                  90                  95      


Ser Pro Asn Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  75
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  75

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ala Lys Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly 
                85                  90                  95      


Pro Thr Phe Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  76
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  76

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Phe 
        35                  40                  45              


Leu Ile Tyr Asp Asn Asn Lys Arg Pro Pro Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Gly 
                85                  90                  95      


Leu Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  77
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  77

Ala Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln 
                85                  90                  95      


Ala Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  78
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  78

Ala Ile Arg Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser His Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Asp Ala Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Ala Pro Met 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Arg Val Asp Leu Lys 
            100                 105             


<210>  79
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  79

Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  80
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  80

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg 
                85                  90                  95      


Met Tyr Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys 
            100                 105                 


<210>  81
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  81

Gln Ala Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His 
            20                  25                  30          


Arg Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile 
                85                  90                  95      


Ser Pro Asn Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  82
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic light chain 
       variable domain

<400>  82

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  83
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  83

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser 
        35                  40                  45              


Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu 
    50                  55                  60                  


Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu 
                85                  90                  95      


Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr 
        115                 120                 125             


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser 
            260             


<210>  84
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  84

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Ser Gly Ser 
            100                 105                 110         


Gly Asn Trp Ser His Pro Gln Phe Glu Lys Gly Ser Gly Ser Gly Glu 
        115                 120                 125             


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
    130                 135                 140                 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
            180                 185                 190         


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  85
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  85

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  86
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  86

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  87
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Asn Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  88
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  88

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  89
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  89

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  90
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  90

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  91
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  92
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  92

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ile Asp Tyr Gly Ser Gly Ser Tyr Ser Pro Arg Thr Ser 
            100                 105                 110         


Tyr Tyr Tyr Tyr Met Ser Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Arg Ala Gly Lys Ala Pro Glu Leu Leu 
            180                 185                 190         


Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Ala Phe Pro 
225                 230                 235                 240 


Leu Thr Phe Gly Pro Gly Thr Lys Val Thr Ile Arg 
                245                 250         


<210>  93
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg Met Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  94
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  94

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  95
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Asn Arg Asp Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  96
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  97
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  97

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  98
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  99
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  100
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  101
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment


<220>
<221>  MOD_RES
<222>  (76)..(76)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (201)..(201)
<223>  Any amino acid

<400>  101

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Glu Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Xaa Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  102
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  102

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  103
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  103

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ala Lys 
        195                 200                 205             


Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly Pro Thr Phe Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Asp Ile Lys 
                245                 250 


<210>  104
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
                245                 250         


<210>  105
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gln Ser Val 
        115                 120                 125             


Leu Thr Gln Pro Arg Ser Leu Ser Gly Ser Pro Gly Gln Ser Val Thr 
    130                 135                 140                 


Ile Ala Cys Thr Gly Ala Ser Thr Asp Val Gly Gly Tyr Asn Tyr Val 
145                 150                 155                 160 


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
                165                 170                 175     


Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln Ala Glu 
        195                 200                 205             


Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser Tyr Thr Phe 
    210                 215                 220                 


Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235     


<210>  106
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Phe 
145                 150                 155                 160 


Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Gly Tyr Asp His Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Gly Pro Lys Leu Leu Ile Tyr Asp 
            180                 185                 190         


Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Tyr Tyr Thr Tyr Trp 
225                 230                 235                 240 


Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  107
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Pro Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  108
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  108

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp 
                165                 170                 175     


Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn 
            180                 185                 190         


Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Val Val 
225                 230                 235                 


<210>  109
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Gly Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu Arg Phe Gly Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250 


<210>  110
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Lys Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Pro Ile Ser Gly Val Gly Asp Tyr Thr Ser Val Ser 
                165                 170                 175     


Trp Tyr Gln His Tyr Pro Gly Lys Thr Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Glu Ala Pro Thr His Thr Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  111
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  111

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  112
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  113
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Ser Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  114
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  114

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg Met Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  115
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  115

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  116
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  117
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  117

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu 
        195                 200                 205             


Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro 
                245                 250                 255     


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  118
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  118

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  119
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  119

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His Arg Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Ala Ile Ser Pro Asn Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  120
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ala Lys 
        195                 200                 205             


Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly Pro Thr Phe Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  121
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  121

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Trp Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  122
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  122

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Phe Asp Ala Ser 
            180                 185                 190         


Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Ala Pro Met Phe Thr Phe Gly 
225                 230                 235                 240 


Pro Gly Thr Arg Val Asp Leu Lys 
                245             


<210>  123
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  123

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  124
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Asn Phe Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Phe Leu Ile Tyr Asp 
            180                 185                 190         


Asn Asn Lys Arg Pro Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Gly Leu Ser Ala Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  125
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  125

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  126
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Phe Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  127
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  127

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala 
    130                 135                 140                 


Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg 
145                 150                 155                 160 


Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     


Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         


Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val 
    210                 215                 220                 


Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
                245                 250         


<210>  128
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  128

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  129
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  129

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  130
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  130

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Glu Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Asn Leu Ser Ala Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 


<210>  131
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His Arg Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile Ser Pro Asn Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  132
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  132

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  133
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  133

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Glu Asp Thr Asn Tyr Ser Gly Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Leu Tyr Gly Asp Tyr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Phe Leu Thr Ile 
        195                 200                 205             


Asn Asn Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Asn Ile Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
225                 230                 235                 240 


Arg 
    


<210>  134
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Asn Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  135
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  135

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  136
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  136

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ile Asp Tyr Gly Ser Gly Ser Tyr Ser Pro Arg Thr Ser 
            100                 105                 110         


Tyr Tyr Tyr Tyr Met Ser Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Arg Ala Gly Lys Ala Pro Glu Leu Leu 
            180                 185                 190         


Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Ala Phe Pro 
225                 230                 235                 240 


Leu Thr Phe Gly Pro Gly Thr Lys Val Thr Ile Arg 
                245                 250         


<210>  137
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg Met Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  138
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  138

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  139
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Asn Arg Asp Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  140
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  140

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  141
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  141

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  142
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment


<220>
<221>  MOD_RES
<222>  (64)..(65)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (68)..(69)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (93)..(93)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (98)..(98)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (102)..(102)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (104)..(104)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (113)..(113)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (145)..(146)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (148)..(149)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (233)..(233)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (244)..(244)
<223>  Any amino acid

<400>  142

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Xaa 
    50                  55                  60                  


Xaa Gly Arg Xaa Xaa Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa Asp Gln Gly Xaa His Xaa Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Xaa Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Xaa Xaa Pro Xaa Xaa Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Val 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Gly Arg Asp Ile Gly Ala Tyr Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Asp Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Val Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ser Ser Xaa Ala Gly Arg Lys Tyr Val Phe 
225                 230                 235                 240 


Gly Thr Gly Xaa Lys Val Thr Val Leu 
                245                 


<210>  143
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  143

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  144
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  145
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  145

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  146
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment


<220>
<221>  MOD_RES
<222>  (76)..(76)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (201)..(201)
<223>  Any amino acid

<400>  146

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Glu Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Xaa Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  147
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  147

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  148
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  148

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ala Lys 
        195                 200                 205             


Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly Pro Thr Phe Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Asp Ile Lys 
                245                 250 


<210>  149
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  149

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
                245                 250         


<210>  150
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gln Ser Val 
        115                 120                 125             


Leu Thr Gln Pro Arg Ser Leu Ser Gly Ser Pro Gly Gln Ser Val Thr 
    130                 135                 140                 


Ile Ala Cys Thr Gly Ala Ser Thr Asp Val Gly Gly Tyr Asn Tyr Val 
145                 150                 155                 160 


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
                165                 170                 175     


Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln Ala Glu 
        195                 200                 205             


Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser Tyr Thr Phe 
    210                 215                 220                 


Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235     


<210>  151
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Phe 
145                 150                 155                 160 


Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Gly Tyr Asp His Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Gly Pro Lys Leu Leu Ile Tyr Asp 
            180                 185                 190         


Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Tyr Tyr Thr Tyr Trp 
225                 230                 235                 240 


Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  152
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Pro Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  153
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  153

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp 
                165                 170                 175     


Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn 
            180                 185                 190         


Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Val Val 
225                 230                 235                 


<210>  154
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Gly Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu Arg Phe Gly Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250 


<210>  155
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Lys Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Pro Ile Ser Gly Val Gly Asp Tyr Thr Ser Val Ser 
                165                 170                 175     


Trp Tyr Gln His Tyr Pro Gly Lys Thr Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Glu Ala Pro Thr His Thr Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  156
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  156

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


Pro 
    


<210>  157
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  157

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
        35                  40                  45              


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
                85                  90                  95      


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser 
        195                 200                 205             


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Thr Arg Ser Asp Pro Thr Ser Ser 
            260                 265                 270 


<210>  158
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  158

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro 
        275         


<210>  159
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Ser Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  160
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  160

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg Met Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  161
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  161

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  162
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  163
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  163

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His Arg Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Ala Ile Ser Pro Asn Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  164
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  164

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ala Lys 
        195                 200                 205             


Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly Pro Thr Phe Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  165
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  165

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Trp Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  166
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  166

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Phe Asp Ala Ser 
            180                 185                 190         


Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Ala Pro Met Phe Thr Phe Gly 
225                 230                 235                 240 


Pro Gly Thr Arg Val Asp Leu Lys 
                245             


<210>  167
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  167

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Asn Phe Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Phe Leu Ile Tyr Asp 
            180                 185                 190         


Asn Asn Lys Arg Pro Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Gly Leu Ser Ala Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  168
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Phe Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  169
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Glu Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Asn Leu Ser Ala Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 


<210>  170
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  170

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His Arg Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile Ser Pro Asn Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  171
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  171

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  172
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  172

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  173
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  173

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  174
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  174

Gln Val Gln Leu Leu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr 
        115                 


<210>  175
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  175

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
            100                 105                 110         


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
        115                 120                 125             


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
    130                 135                 140                 


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
145                 150                 155                 160 


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
                165                 170                 175     


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
            180                 185                 190         


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        195                 200                 205             


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
    210                 215                 220                 


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
225                 230                 235                 240 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
                245                 250                 255     


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            260                 265                 270         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        275                 280                 285             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    290                 295                 300                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  176
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  176

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys 
65                  70                  75                  80  


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val 
                165                 170                 175     


Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn 
            180                 185                 190         


Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu 
        195                 200                 205             


Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val 
225                 230                 235                 240 


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr 
                245                 250                 255     


Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp 
            260                 265                 270         


<210>  177
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  177

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ser Phe Thr Gly Tyr Tyr Met His Trp Val Lys Gln Ser His Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Arg Ile Asn Pro Asn Asn Gly Val Thr Leu 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Thr Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Ser Thr Met Ile Thr Asn Tyr Val Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Val Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Ile Val Met 
145                 150                 155                 160 


Thr Gln Thr Pro Thr Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Gln Ser Pro Thr Leu Leu Ile Ser Tyr Thr Ser 
        195                 200                 205             


Ser Arg Tyr Ala Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Tyr Gly 
    210                 215                 220                 


Thr Asp Phe Thr Phe Thr Ile Ser Thr Leu Gln Ala Glu Asp Leu Ala 
225                 230                 235                 240 


Val Tyr Phe Cys Gln Gln Asp Tyr Asn Ser Pro Pro Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Arg Ser Asp Pro 
            260                 265         


<210>  178
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  178

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu 
            20                  25                  30          


Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val 
        35                  40                  45              


Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr 
65                  70                  75                  80  


Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys 
                85                  90                  95      


Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser 
        195                 200                 205             


Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Thr Arg Ser Asp Pro Thr Ser Ser 
            260                 265                 270 


<210>  179
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  179

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro 
        275         


<210>  180
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  180

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  181
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  181

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  182
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  182

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  183
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  183

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  184
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  184

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  185
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  185

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  186
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  186

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Gln Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  187
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  187

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
145                 150                 155                 160 


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  188
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  188

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser 
            180                 185                 190         


Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  189
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  189

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser 
            180                 185                 190         


Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys Leu Ser Ser Val Thr 
        195                 200                 205             


Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  190
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  190

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Ser Tyr Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr 
65                  70                  75                  80  


Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met 
145                 150                 155                 160 


Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser 
                165                 170                 175     


Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr 
            180                 185                 190         


Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu 
        195                 200                 205             


Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu 
225                 230                 235                 240 


Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro 
                245                 250                 255     


Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  191
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  191

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  192
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  192

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  193
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  193

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala 
    130                 135                 140                 


Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg 
145                 150                 155                 160 


Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     


Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         


Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val 
    210                 215                 220                 


Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Leu Lys Arg Ser Asp Pro 
                245                 250         


<210>  194
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  194

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Lys Ala Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
    130                 135                 140                 


Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp 
145                 150                 155                 160 


Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
            180                 185                 190         


Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe 
        195                 200                 205             


Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys 
    210                 215                 220                 


Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Ser Val Thr Val Ser Ser Asp 
                245                 250 


<210>  195
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  195

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  196
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  196

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Ile Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala 
    130                 135                 140                 


Pro Ser Ile Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg 
145                 150                 155                 160 


Ser Ser Lys Ser Leu Leu Asn Ser Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     


Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         


Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val 
    210                 215                 220                 


Gly Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly 
225                 230                 235                 240 


Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
                245                 250     


<210>  197
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  197

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Ser Ser Ser Leu Lys Ser 
        195                 200                 205             


Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu Lys 
    210                 215                 220                 


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser His His His His His His His His 
            260                 265                 270     


<210>  198
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu 
    130                 135                 140                 


Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile 
145                 150                 155                 160 


Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Asp Lys Asn Asn 
            180                 185                 190         


Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Asn Trp Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  199
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  200
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  200

Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Ile Asp Tyr Gly Ser Gly Ser Tyr Ser Pro Arg Thr Ser 
            100                 105                 110         


Tyr Tyr Tyr Tyr Met Ser Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val 
145                 150                 155                 160 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser 
                165                 170                 175     


Tyr Leu Asn Trp Tyr Gln Gln Arg Ala Gly Lys Ala Pro Glu Leu Leu 
            180                 185                 190         


Ile Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln 
    210                 215                 220                 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Asp Ala Phe Pro 
225                 230                 235                 240 


Leu Thr Phe Gly Pro Gly Thr Lys Val Thr Ile Arg 
                245                 250         


<210>  201
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  201

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg Met Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  202
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Asn Arg Asp Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  203
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  203

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  204
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment


<220>
<221>  MOD_RES
<222>  (64)..(65)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (68)..(69)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (93)..(93)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (98)..(98)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (102)..(102)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (104)..(104)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (113)..(113)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (145)..(146)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (148)..(149)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (233)..(233)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (244)..(244)
<223>  Any amino acid

<400>  204

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Xaa 
    50                  55                  60                  


Xaa Gly Arg Xaa Xaa Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa Asp Gln Gly Xaa His Xaa Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Xaa Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Xaa Xaa Pro Xaa Xaa Ala Ser Gly Ser Pro Gly Gln Ser Val Thr Val 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Gly Arg Asp Ile Gly Ala Tyr Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly 
            180                 185                 190         


Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Asp Asn Thr Ala Ser Leu Thr Val Ser Gly Leu Gln Val Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ser Ser Xaa Ala Gly Arg Lys Tyr Val Phe 
225                 230                 235                 240 


Gly Thr Gly Xaa Lys Val Thr Val Leu 
                245                 


<210>  205
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment


<220>
<221>  MOD_RES
<222>  (76)..(76)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (201)..(201)
<223>  Any amino acid

<400>  205

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Xaa Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Glu Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Xaa Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  206
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  206

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ala Lys 
        195                 200                 205             


Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly Pro Thr Phe Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Asp Ile Lys 
                245                 250 


<210>  207
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  207

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
                245                 250         


<210>  208
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gln Ser Val 
        115                 120                 125             


Leu Thr Gln Pro Arg Ser Leu Ser Gly Ser Pro Gly Gln Ser Val Thr 
    130                 135                 140                 


Ile Ala Cys Thr Gly Ala Ser Thr Asp Val Gly Gly Tyr Asn Tyr Val 
145                 150                 155                 160 


Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr 
                165                 170                 175     


Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
            180                 185                 190         


Lys Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Gly Leu Gln Ala Glu 
        195                 200                 205             


Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser Tyr Thr Phe 
    210                 215                 220                 


Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235     


<210>  209
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  209

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Phe 
145                 150                 155                 160 


Ser Cys Thr Gly Ala Ser Ser Asp Val Gly Gly Tyr Asp His Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Gly Pro Lys Leu Leu Ile Tyr Asp 
            180                 185                 190         


Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Phe Ala Gly Tyr Tyr Thr Tyr Trp 
225                 230                 235                 240 


Leu Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  210
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Cys Ser Tyr Ala Gly Arg Tyr Asn Ser Val Pro Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  211
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  211

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp 
                165                 170                 175     


Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn 
            180                 185                 190         


Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Glu Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Val Val 
225                 230                 235                 


<210>  212
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Gly Asp Tyr Tyr Cys Gly Thr Trp Asp Ile Ser Leu Arg Phe Gly Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250 


<210>  213
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  213

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Lys Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Pro Ile Ser Gly Val Gly Asp Tyr Thr Ser Val Ser 
                165                 170                 175     


Trp Tyr Gln His Tyr Pro Gly Lys Thr Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Gln Arg Pro Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Asp Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Glu Ala Pro Thr His Thr Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  214
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  214

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Phe Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Thr Ser Asp Asp Val Ser Trp Tyr Gln Gln His 
                165                 170                 175     


Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr Asp Val Ser Lys Arg Pro 
            180                 185                 190         


Ser Gly Val Pro His Arg Phe Ser Gly Ser Arg Ser Gly Arg Ala Ala 
        195                 200                 205             


Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Phe 
    210                 215                 220                 


Cys Ser Ser Tyr Ala Gly Arg Tyr Asn Ser Val Leu Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  215
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  215

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr 
145                 150                 155                 160 


Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser His Pro Arg Met Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  216
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  216

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  217
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  217

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Leu Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Arg Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Val Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Ser Ser Ser Thr Leu Leu 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250         


<210>  218
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  218

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His Arg Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Ala Ile Ser Pro Asn Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  219
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  219

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly His Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Arg Ser Asp Val Gly Gly Phe Asp Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His Asn Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp 
            180                 185                 190         


Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ala Lys 
        195                 200                 205             


Ser Gly Ile Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Arg Pro Gly Pro Thr Phe Val 
225                 230                 235                 240 


Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  220
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  220

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Trp Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  221
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  221

Gln Met Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser His Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Phe Asp Ala Ser 
            180                 185                 190         


Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Ala Pro Met Phe Thr Phe Gly 
225                 230                 235                 240 


Pro Gly Thr Arg Val Asp Leu Lys 
                245             


<210>  222
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  222

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ala Tyr Asn Phe Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Phe Leu Ile Tyr Asp 
            180                 185                 190         


Asn Asn Lys Arg Pro Pro Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Gly Leu Ser Ala Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  223
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Phe Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250 


<210>  224
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  224

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Glu Val Thr Ile 
145                 150                 155                 160 


Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn 
            180                 185                 190         


Asp Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Gly Asn Leu Ser Ala Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 


<210>  225
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  225

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val Leu 
    130                 135                 140                 


Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ile Ser Ser Gly Val Asp Ser His Arg Tyr Val Ser 
                165                 170                 175     


Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp 
            180                 185                 190         


Phe Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Ala Ile Ser Pro Asn Tyr 
225                 230                 235                 240 


Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
                245                 250     


<210>  226
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  226

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp Ser Ala Glu His Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ile Arg Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Val Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser 
            180                 185                 190         


Asn Val Lys Ala Gly Val Pro Ser Arg Phe Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Gln Ala Tyr Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Asp Ile Lys 
                245                 


<210>  227
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  227

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Glu Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Pro Glu Leu Ile Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Val Met His Trp Val Lys Gln 
    50                  55                  60                  


Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn 
65                  70                  75                  80  


Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr 
                85                  90                  95      


Ser Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr 
            100                 105                 110         


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Thr Tyr Tyr Val 
        115                 120                 125             


Gly Ser Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Val Met Thr Gln Ala Ala Pro Ser Ile Pro Val Thr Pro 
                165                 170                 175     


Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Asn 
            180                 185                 190         


Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln 
        195                 200                 205             


Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg 
225                 230                 235                 240 


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Val Cys Met Gln 
                245                 250                 255     


His Leu Glu Tyr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            260                 265                 270         


Lys Arg Ser Asp Pro 
        275         


<210>  228
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  228

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  229
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  229

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  230
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  230

Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg 
1               5                   10                  15      


Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala 
            20                  25                  30          


Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr 
        35                  40                  45              


Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val 
    50                  55                  60                  


Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn 
                85                  90                  95      


Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser 
            100                 105                 110     


<210>  231
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  231

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  232
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  232

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  233
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  233

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  234
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  234

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  235
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  235

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  236
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  236

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Ile Val Ile Asn 
1               5                   10                  15      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            20                  25                  30          


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40              


<210>  237
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  238
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  238

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  239
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  239

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  240
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  240

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  241
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  241

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  242
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  242

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  243
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  243

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  244
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  244

His Leu Trp Arg Arg Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu Glu 
1               5                   10                  15      


Gln Gly Ile His Pro Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu 
            20                  25                  30          


Gln Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu 
        35                  40                  45              


Pro Glu Pro Glu Gln Leu 
    50                  


<210>  245
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  245

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  246
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  246

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  247
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  247

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Ile Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  248
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  248

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Tyr Glu Leu 
        35                  40          


<210>  249
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  249

Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45              


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    50                  55                  60                  


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
65                  70                  75                  80  


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                85                  90                  95      


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            100                 105                 110         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        115                 120                 125             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    130                 135                 140                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
145                 150                 155                 160 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                165                 170                 175     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            180                 185                 190         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        195                 200                 205             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    210                 215                 220                 


Arg 
225 


<210>  250
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  250

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        35                  40                  45              


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    50                  55                  60                  


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
65                  70                  75                  80  


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                85                  90                  95      


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            100                 105                 110         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        115                 120                 125             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    130                 135                 140                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150                 


<210>  251
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  251

Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys Lys 
1               5                   10                  15      


Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val Ser 
            20                  25                  30          


Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp Asp 
        35                  40                  45              


Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe Pro 
    50                  55                  60                  


Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val Gln 
65                  70                  75                  80  


Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser Phe 
                85                  90                  95      


Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala Cys 
            100                 105                 110         


Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser 
        115                 120                 125             


Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly 
    130                 135                 140                 


Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile 
145                 150                 155                 160 


Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu 
                165                 170                 175     


Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln 
            180                 185                 190         


Asn Gln 
        


<210>  252
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  252

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  253
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  253

Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu Val Ser Phe Ser Gln 
1               5                   10                  15      


Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val Glu Asn Phe Glu Ala 
            20                  25                  30          


Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys Gly Phe Ala Glu Glu 
        35                  40                  45              


Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln Pro Lys Tyr Ala Ala 
    50                  55                  60                  


Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr Asn Asn Val Leu Pro 
65                  70                  75                  80  


Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln Thr His Ser Thr Asp 
                85                  90                  95      


Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr His Ser Lys Lys Asp 
            100                 105                 110         


Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr Leu Lys Asp Phe Trp 
        115                 120                 125             


Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile Ile Met Leu Thr Lys 
    130                 135                 140                 


Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu Tyr Trp Pro Ser Lys 
145                 150                 155                 160 


Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala Met Thr Ser Glu Ile 
                165                 170                 175     


Val Leu Pro Glu Trp Thr Ile Arg Asp Phe Thr Val Lys Asn Ile Gln 
            180                 185                 190         


Thr Ser Glu Ser His Pro Leu Arg Gln Phe His Phe Thr Ser Trp Pro 
        195                 200                 205             


Asp His Gly Val Pro Asp Thr Thr Asp Leu Leu Ile Asn Phe Arg Tyr 
    210                 215                 220                 


Leu Val Arg Asp Tyr Met Lys Gln Ser Pro Pro Glu Ser Pro Ile Leu 
225                 230                 235                 240 


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Phe Ile Ala Ile 
                245                 250                 255     


Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu Asn Thr Val Asp Val Tyr 
            260                 265                 270         


Gly Ile Val Tyr Asp Leu Arg Met His Arg Pro Leu Met Val Gln Thr 
        275                 280                 285             


Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys Val Leu Asp Ile Val Arg 
    290                 295                 300                 


Ser Gln Lys Asp Ser Lys Val Asp Leu Ile Tyr Gln Asn Thr Thr Ala 
305                 310                 315                 320 


Met Thr Ile Tyr Glu Asn Leu Ala Pro Val Thr Thr Phe Gly Lys Thr 
                325                 330                 335     


Asn Gly Tyr Ile Ala 
            340     


<210>  254
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  254

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  255
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  255

Phe Ala Ala Tyr Arg Ser 
1               5       


<210>  256
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  256

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  257
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  257

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  258
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  258

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  259
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  259

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
65                  70                  75                  80  


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                85                  90                  95      


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105     


<210>  260
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  260

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val Lys Arg 
        35                  40                  45              


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    50                  55                  60                  


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
65                  70                  75                  80  


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                85                  90                  95      


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            100                 105                 110         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        115                 120                 125             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    130                 135                 140                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
145                 150                 155                 160 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                165                 170                 175     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            180                 185                 190         


His Met Gln Ala Leu Pro Pro Arg 
        195                 200 


<210>  261
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  261

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


<210>  262
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  262

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp 
        35                  40                  45              


Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu 
    50                  55                  60                  


Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe 
65                  70                  75                  80  


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                85                  90                  95      


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            100                 105                 110         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        115                 120                 125             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    130                 135                 140                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
145                 150                 155                 160 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                165                 170                 175     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            180                 185             


<210>  263
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
            20                  25                  30          


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        35                  40                  45              


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    50                  55                  60                  


Glu Gly Gly Cys Glu Leu 
65                  70  


<210>  264
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  264

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
65                  70                  75                  80  


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                85                  90                  95      


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            100                 105             


<210>  265
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  265

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                85                  90                  95      


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            100                 105                 110         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        115                 120                 125             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    130                 135                 140                 


Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150             


<210>  266
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  266

Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
1               5                   10                  15      


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            20                  25                  30          


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
        35                  40                  45              


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    50                  55                  60                  


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
65                  70                  75                  80  


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                85                  90                  95      


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            100                 105                 110         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        115                 120                 125             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    130                 135                 140                 


Met Gln Ala Leu Pro Pro Arg 
145                 150     


<210>  267
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  268
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  269
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  269

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  270
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  271
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  272
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  272

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  273
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  274
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  274

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  275
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  276
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  276

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  277
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  277

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  278
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  279
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  280
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  281
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  282
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  282

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  283
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  283

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  284
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  284

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  285
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  285

Arg Val Lys Phe Ser Arg Ser Ala Glu Pro Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  286
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  286

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  287
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  287

Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            20                  25                  30          


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        35                  40                  45              


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  288
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  288

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            20                  25                  30          


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        35                  40                  45              


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    50                  55                  60                  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
65                  70                  75                  80  


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                85                  90                  95      


Pro Arg 
        


<210>  289
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  289

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Val 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  290
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Val Gly Ile Val Leu Thr Leu Leu Val Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Arg Val Lys 
    50                  55                  60                  


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
65                  70                  75                  80  


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                85                  90                  95      


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            100                 105                 110         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        115                 120                 125             


Ala Glu Ala Val Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    130                 135                 140                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
145                 150                 155                 160 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                165                 170             


<210>  291
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  291

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  292
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  292

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    50                  55                  60  


<210>  293
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  293

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  294
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  294

Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  295
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  295

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  296
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  296

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  297
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  297

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  298
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  298

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  299
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  299

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  300
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  300

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110 


<210>  301
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  301

Asp Pro Lys Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly 
1               5                   10                  15      


Val Ile Leu Thr Ala Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala 
            20                  25                  30          


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        35                  40                  45              


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    50                  55                  60                  


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
65                  70                  75                  80  


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                85                  90                  95      


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            100                 105                 110         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        115                 120                 125             


Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135         


<210>  302
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  303
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  303

Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly 
1               5                   10                  15      


Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His 
            20                  25                  30          


Ser Thr Leu Ala Lys Ile 
        35              


<210>  304
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  305
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  306
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  307
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  307

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  308
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  308

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  309
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  309

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Ile Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  310
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  310

Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45          


<210>  311
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  311

Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr 
1               5                   10                  15      


Gly Val Phe Val Lys Met Ala Pro Thr Glu Ala Glu Cys Glu Lys Gln 
            20                  25                  30          


Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
        35                  40      


<210>  312
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  312

Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr 
1               5                   10                  15      


Gly Val Tyr Met Asn Met Thr Pro Arg Arg Pro Glu Cys Glu Lys Gln 
            20                  25                  30          


Phe Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  45          


<210>  313
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  313

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  314
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  315
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  316
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  317
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  318
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  319
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  320
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  321
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  322
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  322

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  323
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  323

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  324
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  324

Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
1               5                   10                  15      


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
            20                  25                  30          


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
        35                  40                  45              


Val 
    


<210>  325
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  325

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Phe 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  326
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  326

Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
1               5                   10                  15      


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
            20                  25                  30          


Glu Asn Cys Ser His His Leu 
        35                  


<210>  327
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  327

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        35                  40                  45              


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    50                  55                  60                  


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
65                  70                  75                  80  


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                85                  90                  95      


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            100                 105                 110         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        115                 120                 125             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    130                 135                 140                 


Ala Leu Pro Pro Arg 
145                 


<210>  328
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  329
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg 
            180 


<210>  330
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


<210>  331
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  332
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  332

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  333
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  333

Asp Pro Lys Leu Cys Tyr Ile Leu Asp Ala Ile Leu Phe Leu Tyr Gly 
1               5                   10                  15      


Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile Gln Val Arg Lys 
            20                  25                  30          


Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu 
        35                  40                  45              


Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro 
    50                  55                  60                  


Pro Gln 
65      


<210>  334
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  334

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  335
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  335

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      


<210>  336
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  336

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
            20                  25                  30      


<210>  337
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  337

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  338
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  338

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  339
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  339

Ala Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly 
1               5                   10                  15      


Gly Phe Ile Phe Trp Arg Lys Lys Arg Lys Asp Ala Lys Asn Asn Glu 
            20                  25                  30          


Val Ser Phe Ser Gln Ile Lys Pro Lys Lys Ser Lys Leu Ile Arg Val 
        35                  40                  45              


Glu Asn Phe Glu Ala Tyr Phe Lys Lys Gln Gln Ala Asp Ser Asn Cys 
    50                  55                  60                  


Gly Phe Ala Glu Glu Tyr Glu Asp Leu Lys Leu Val Gly Ile Ser Gln 
65                  70                  75                  80  


Pro Lys Tyr Ala Ala Glu Leu Ala Glu Asn Arg Gly Lys Asn Arg Tyr 
                85                  90                  95      


Asn Asn Val Leu Pro Tyr Asp Ile Ser Arg Val Lys Leu Ser Val Gln 
            100                 105                 110         


Thr His Ser Thr Asp Asp Tyr Ile Asn Ala Asn Tyr Met Pro Gly Tyr 
        115                 120                 125             


His Ser Lys Lys Asp Phe Ile Ala Thr Gln Gly Pro Leu Pro Asn Thr 
    130                 135                 140                 


Leu Lys Asp Phe Trp Arg Met Val Trp Glu Lys Asn Val Tyr Ala Ile 
145                 150                 155                 160 


Ile Met Leu Thr Lys Cys Val Glu Gln Gly Arg Thr Lys Cys Glu Glu 
                165                 170                 175     


Tyr Trp Pro Ser Lys Gln Ala Gln Asp Tyr Gly Asp Ile Thr Val Ala 
            180                 185                 190         


Met Thr Ser Glu Ile Val Leu Pro Glu Val Val Thr Ile Arg Asp Phe 
        195                 200                 205             


Thr Val Lys Asn Ile Gln Thr Ser Glu Ser His Pro Leu Arg Gln Phe 
    210                 215                 220                 


His Phe Thr Ser Trp Pro Asp His Gly Val Pro Asp Thr Thr Asp Leu 
225                 230                 235                 240 


Leu Ile Asn Phe Arg Tyr Leu Val Arg Asp Tyr Met Lys Gln Ser Pro 
                245                 250                 255     


Pro Glu Ser Pro Ile Leu Val His Cys Ser Ala Gly Val Gly Arg Thr 
            260                 265                 270         


Gly Thr Phe Ile Ala Ile Asp Arg Leu Ile Tyr Gln Ile Glu Asn Glu 
        275                 280                 285             


Asn Thr Val Asp Val Tyr Gly Ile Val Tyr Asp Leu Arg Met His Arg 
    290                 295                 300                 


Pro Leu Met Val Gln Thr Glu Asp Gln Tyr Val Phe Leu Asn Gln Cys 
305                 310                 315                 320 


Val Leu Asp Ile Val Arg Ser Gln Lys Asp Ser Lys Val Asp Leu Ile 
                325                 330                 335     


Tyr Gln Asn Thr Thr Ala Met Thr Ile Tyr Glu Asn Leu Ala Pro Val 
            340                 345                 350         


Thr Thr Phe Gly Lys Thr Asn Gly Tyr Ile Ala 
        355                 360             


<210>  340
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  340

Ala Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly 
1               5                   10                  15      


Gly Phe Ile Phe Trp 
            20      


<210>  341
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  341

Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp 
1               5                   10                  15      


Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp 
            20                  25                  30          


Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg 
        35                  40                  45              


Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys 
    50                  55                  60                  


Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile 
65                  70                  75                  80  


Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys 
                85                  90                  95      


Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser 
            100                 105                 110         


Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr 
        115                 120                 125             


Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser 
    130                 135                 140                 


Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe 
145                 150                 155                 160 


Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro 
                165                 170                 175     


Val Ser Cys Pro Glu Lys Gly Leu Asp 
            180                 185 


<210>  342
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  342

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Thr His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala His Ile Phe Trp 
    50                  55                  60                  


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
65                  70                  75                  80  


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                85                  90                  95      


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105     


<210>  343
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  343

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  344
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  344

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  345
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  345

Ile Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          


Arg 
    


<210>  346
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  346

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  347
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  348
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  348

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe His Phe Trp Val 
            20                  25      


<210>  349
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Gly Gly Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  350
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  350

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  351
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  351

Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
            20                  25                  30          


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
        35                  40                  45              


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
    50                  55                  60                  


Ala Ala Tyr Arg Ser 
65                  


<210>  352
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  352

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
65                  70                  75                  80  


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                85                  90                  95      


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            100                 105                 110         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        115                 120                 125             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    130                 135                 140                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
145                 150                 155                 160 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                165                 170                 175     


Leu Pro Pro Arg 
            180 


<210>  353
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  353

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro 
65                  70                  75                  80  


Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp 
                85                  90                  95      


Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala 
            100                 105                 110         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        115                 120                 125             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    130                 135                 140                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
145                 150                 155                 160 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                165                 170                 175     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            180                 185                 190         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        195                 200                 205             


His Met Gln Ala Leu Pro Pro Arg 
    210                 215     


<210>  354
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  354

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Arg Val Lys Phe 
            20                  25                  30          


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        35                  40                  45              


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    50                  55                  60                  


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
65                  70                  75                  80  


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                85                  90                  95      


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            100                 105                 110         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        115                 120                 125             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    130                 135                 140 


<210>  355
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  355

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            100                 105                 110         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        115                 120                 125             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    130                 135                 140                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
145                 150                 155                 160 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                165                 170                 175     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            180                 185                 190         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        195                 200                 205             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 220         


<210>  356
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  356

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  357
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu 
    50      


<210>  358
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  358

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  359
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  359

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  360
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  361
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  361

Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
1               5                   10                  15      


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
            20                  25                  30          


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
        35                  40                  45              


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
    50                  55                  60                  


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
65                  70                  75                  80  


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
                85                  90                  95      


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
            100                 105                 110         


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
        115                 120                 125             


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
    130                 135                 140                 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
145                 150                 155                 160 


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
                165                 170                 175     


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
            180                 185                 190         


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
        195                 200                 205             


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
    210                 215                 220                 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
225                 230                 235                 240 


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
            260                 265                 270         


Trp His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
        275                 280                 285             


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
    290                 295                 300                 


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
305                 310                 315                 320 


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
                325                 330                 335     


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
            340                 345                 350         


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
        355                 360                 365             


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
    370                 375                 380                 


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
385                 390                 395                 400 


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
                405                 410                 415     


Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 
            420                 425                 430         


Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 
        435                 440                 445             


Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 
    450                 455                 460                 


Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 
465                 470                 475                 480 


Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln 
                485                 490                 495     


Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu 
            500                 505                 510         


Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu 
        515                 520                 525             


Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln Tyr 
    530                 535                 540                 


Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu Ile 
545                 550                 555                 560 


Ser Met Ile Gln Trp Lys Gln Lys Leu Pro Gln Lys Asn Ser Ser Glu 
                565                 570                 575     


Gly Asn Lys His His Lys Ser Thr Pro Leu Leu Ile His Cys Arg Asp 
            580                 585                 590         


Gly Ser Gln Gln Thr Gly Ile Phe Cys Ala Leu Leu Asn Leu Leu Glu 
        595                 600                 605             


Ser Ala Glu Thr Glu Glu Trp Asp Ile Phe Gln Trp Lys Ala Leu Arg 
    610                 615                 620                 


Lys Ala Arg Pro Gly Met Val Ser Thr Phe Glu Gln Tyr Gln Phe Leu 
625                 630                 635                 640 


Tyr Asp Val Ile Ala Ser Thr Tyr Pro Ala Gln Asn Gly Gln Val Lys 
                645                 650                 655     


Lys Asn Asn His Gln Glu Asp Lys Ile Glu Phe Asp Asn Glu Val Asp 
            660                 665                 670         


Lys Val Lys Gln Asp Ala Asn Cys Val Asn Pro Leu Gly Ala Pro Glu 
        675                 680                 685             


Lys Leu Pro Glu Ala Lys Glu Gln Ala Glu Gly Ser Glu Pro Thr Ser 
    690                 695                 700                 


Gly Thr Glu Gly Pro Glu His Ser Val Asn Gly Pro Ala Ser Pro Ala 
705                 710                 715                 720 


Leu Asn Gln Gly Ser 
                725 


<210>  362
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  362

Pro Leu Phe Ile Pro Val Ala Val Met Val Thr Ala Phe Ser Gly Leu 
1               5                   10                  15      


Ala Phe Ile Ile Trp Leu Ala 
            20              


<210>  363
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  363

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  364
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  365
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  365

Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    50                  55                  60                  


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
65                  70                  75                  80  


Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
                85                  90                  95      


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
            100                 105                 110         


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
        115                 120                 125             


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    130                 135                 140                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
145                 150                 155                 160 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                165                 170                 175     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
            180                 185                 190         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        195                 200                 205             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    210                 215                 220                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
225                 230                 235                 240 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                245                 250                 255     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            260                 265                 270         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        275                 280                 285     


<210>  366
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  366

Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
65                  70                  75                  80  


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
                85                  90                  95      


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
            100                 105                 110         


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
        115                 120                 125             


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
    130                 135                 140                 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
145                 150                 155                 160 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
                165                 170                 175     


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
            180                 185                 190         


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
        195                 200                 205             


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
    210                 215                 220                 


Pro Arg 
225     


<210>  367
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  367

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn 
            


<210>  368
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  368

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  369
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  369

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  370
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  370

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Arg 
            20                  25  


<210>  371
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  371

Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
1               5                   10                  15      


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            20                  25                  30          


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45              


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    50                  55                  60                  


Val Ile Thr Leu Tyr Cys Asn 
65                  70      


<210>  372
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  372

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Val Cys Arg 
            20                  25  


<210>  373
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  373

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  374
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  374

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  375
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  375

Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val 
1               5                   10                  15      


Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile 
            20                  25                  30          


Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln 
        35                  40                  45              


Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu 
    50                  55                  60                  


Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu 
65                  70                  75                  80  


Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu 
                85                  90                  95      


Leu Thr Pro Ser Asp 
            100     


<210>  376
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  376

Phe Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly 
1               5                   10                  15      


Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys 
            20                  25                  30          


Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn 
        35                  40                  45              


Pro Lys Asn Asn 
    50          


<210>  377
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  378
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  379
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  380
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  380

Asp Ile Phe Ile Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr 
1               5                   10                  15      


Gly Leu Phe Ile Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile 
            20                  25                  30          


Lys Arg Thr Arg Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro 
        35                  40                  45              


Asn Pro Lys Asn Asn Arg 
    50                  


<210>  381
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  381

Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys Val 
1               5                   10                  15      


Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            20                  25                  30      


<210>  382
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  382

Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly 
1               5                   10                  15      


Val Val Phe Gly Ile Leu Ile Ile 
            20                  


<210>  383
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  383

Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly 
1               5                   10                  15      


Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro 
            20                  25                  30          


Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr 
        35                  40                  45              


Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys 
    50                  55                  60                  


Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys 
65                  70                  75                  80  


Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val 
                85                  90                  95      


Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu 
            100                 105                 110         


Ile 
    


<210>  384
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  384

Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
1               5                   10                  15      


Ala Cys Phe Cys Val 
            20      


<210>  385
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  385

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala Ala Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  386
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  386

Asp Lys Thr His Thr 
1               5   


<210>  387
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  387

Cys Pro Pro Cys 
1               


<210>  388
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  388

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  389
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  389

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  390
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  390

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  391
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  391

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  392
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  392

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  393
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  393

Val Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  394
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  394

Leu Asp Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  395
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  395

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro 
        35                  


<210>  396
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  396

Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
1               5                   10          


<210>  397
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  397

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  398
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  398

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


<210>  399
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  399

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  400
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  400

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  401
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  401

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Glu Pro Lys 
        35                  40                  45              


Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
    50                  55                  60                  


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
65                  70                  75                  


<210>  402
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  402

Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
1               5                   10                  15      


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            20                  25                  30          


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        35                  40                  45              


Asp Ile Tyr 
    50      


<210>  403
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  403

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  404
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  404

Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
1               5                   10                  15      


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
            20                  25                  30          


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  


<210>  405
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  405

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  406
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  406

Leu Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10      


<210>  407
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  407

Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val 
1               5                   10                  15      


Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile 
            20                  25                  30          


Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln 
        35                  40                  45              


Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu 
    50                  55                  60                  


Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu 
65                  70                  75                  80  


Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu 
                85                  90                  95      


Leu Thr Pro Ser Asp 
            100     


<210>  408
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  408

Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      


<210>  409
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  409

Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      


<210>  410
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  410

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  411
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  411

Tyr Val Thr Val Ser Ser Gln Asp Pro Ala Glu Pro Lys Ser Pro Asp 
1               5                   10                  15      


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys Lys Asp Pro Lys 
                245     


<210>  412
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  412

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        35                  40                  45  


<210>  413
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  413

Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  414
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  414

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        35                  40              


<210>  415
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  415

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  416
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  416

Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


<210>  417
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  417

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  418
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  418

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  419
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  419

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  420
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  420

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  421
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  421

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  422
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  422

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  423
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  423

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu His Pro Ser Leu Pro Pro Gln 
145                 150                 155                 160 


Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys Leu 
                165                 170                 175     


Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser Trp 
            180                 185                 190         


Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu Met 
        195                 200                 205             


Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro Ala 
    210                 215                 220                 


Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser Val 
225                 230                 235                 240 


Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr Cys 
                245                 250                 255     


Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg Ser 
            260                 265                 270         


Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280     


<210>  424
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  424

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Val Val Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
    210                 215                 220                 


Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp 
225                 230                 235                 240 


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
                245                 250                 255     


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
            260                 265                 270         


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280             


<210>  425
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  425

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  426
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  426

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  427
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  427

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  428
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  428

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  429
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  429

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  430
<211>  234
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (91)..(91)
<223>  Any amino acid

<400>  430

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Xaa Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  431
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  431

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230                 


<210>  432
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  432

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  433
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  433

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  434
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  434

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Val Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210>  435
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  435

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
1               5                   10              


<210>  436
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  436

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  437
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  437

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235 


<210>  438
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  438

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  439
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  439

Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
            20                  25                  30          


Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    50                  55                  60                  


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
65                  70                  75                  80  


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                85                  90                  95      


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            100                 105                 110         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        115                 120                 125             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    130                 135                 140                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
145                 150                 155                 160 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                165                 170                 175     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            180                 185                 190         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        195                 200                 205             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    210                 215                 220                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
225                 230                 235 


<210>  440
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  440

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  441
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  441

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  442
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  442

Glu Leu Lys Thr Pro Leu Gly Asp Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210>  443
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  443

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  444
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  444

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  445
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  445

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  446
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  446

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  447
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  447

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            20                  25                  30          


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        35                  40                  45              


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    50                  55                  60                  


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
65                  70                  75                  80  


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            100                 105                 110         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        115                 120                 125             


Lys 
    


<210>  448
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  448

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Gln Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Val Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  449
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  449

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Gln Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Val Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  450
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  450

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  451
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  451
gaatctaagt acggaccgcc ctgcccccct tgccct                                 36


<210>  452
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  452

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  453
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  453

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  454
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  454

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  455
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  455

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  456
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  456

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  457
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  457

Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   


<210>  458
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  458

Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10  


<210>  459
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  459

Glu Val Val Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10              


<210>  460
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  460

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Leu Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  461
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  461

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gly Gly Ser 
1               5                   10                  15      


Ser Gly Gly Gly Ser Gly 
            20          


<210>  462
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  462

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Ile Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  463
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  463

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Leu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Ile Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  464
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  464

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  465
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  465

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  466
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  466

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  467
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  467
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  468
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  468
accacaaccc cagcacctcg cccaccaaca ccagcaccaa ccatcgcatc ccagccactg       60

tctctgaggc ccgaggcatg taggcctgca gcaggaggcg ccgtgcacac caggggcctg      120

gactttgcct gcgatatcta tatctgggca ccactggcag gaacatgtgg cgtgctgctg      180

ctgtccctgg tcatcaccct gtattgc                                          207


<210>  469
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  470
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  470

Gly Gly Ser Gly Gly 
1               5   


<210>  471
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Cleavage site

<400>  471

Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser Lys 
1               5                   10          


<210>  472
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  472
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagagct ccgaggtgct gggaagcggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatttgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtctag ccggggctcc      420

tctgacccac agggagtgac atgcggagca gccaccctgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag      660

ctgaagccac tgaagaattc tcgccaggtg gaggtgagct gggagtaccc agacacctgg      720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagtccaag      780

cgggagaaga aggacagagt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag      840

aacgcctcca tctctgtgag ggcccaggat cgctactatt ctagctcctg gagcgagtgg      900

gcatccgtgc catgttct                                                    918


<210>  473
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  473
atctgggagc tcaagaaaga cgtgtacgtg gtggaactgg actggtaccc cgacgcccct       60

ggcgaaatgg tggtgctgac atgcgacacc cctgaggagg atggcattac ctggaccctc      120

gatcagagct ccgaggtgct gggcagcggc aaaaccctga ccatccaggt gaaggagttt      180

ggcgatgccg gccagtacac atgtcacaag ggcggcgagg tgctgagcca ctccctgctg      240

ctgctccaca agaaggaaga tggcatctgg agcaccgaca ttctgaagga tcagaaggag      300

cccaagaaca agacattcct gaggtgtgag gccaagaact acagcggcag gtttacctgc      360

tggtggctga caacaatcag caccgacctc acattctccg tcaagtcctc caggggttct      420

tccgaccctc aaggcgtgac atgcggcgct gccaccctga gcgctgagag agtcaggggc      480

gacaacaagg agtacgagta cagcgtcgaa tgtcaggagg acagcgcctg tcccgccgct      540

gaagagagcc tgcctatcga ggtgatggtg gacgccgtgc acaaactgaa gtatgagaat      600

tacacctcca gcttcttcat cagggacatc atcaaacccg atccccccaa gaacctgcag      660

ctgaagcctc tgaagaacag cagacaggtc gaagtgtcct gggagtaccc tgatacctgg      720

tccacacccc acagctactt cagcctgacc ttttgcgtgc aggtgcaggg caagagcaaa      780

agggagaaga aggacagggt gtttaccgac aagacctccg ccacagtgat ttgcagaaag      840

aacgcctcca tcagcgtgag ggcccaggac aggtattaca gcagctcctg gagcgaatgg      900

gctagcgtgc cctgtagc                                                    918


<210>  474
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  474
atctgggagc tcaagaaaga cgtgtacgtg gtggaactgg actggtaccc cgacgcccct       60

ggcgaaatgg tggtgctgac atgcgacacc cctgaggagg atggcattac ctggaccctc      120

gatcagagct ccgaggtgct gggcagcggc aaaaccctga ccatccaggt gaaggagttt      180

ggcgatgccg gccagtacac atgtcacaag ggcggcgagg tgctgagcca ctccctgctg      240

ctgctccaca agaaggaaga tggcatctgg agcaccgaca ttctgaagga tcagaaggag      300

cccaagaaca agacattcct gaggtgtgag gccaagaact acagcggcag gtttacctgc      360

tggtggctga caacaatcag caccgacctc acattctccg tcaagtcctc caggggttct      420

tccgaccctc aaggcgtgac atgcggcgct gccaccctga gcgctgagag agtcaggggc      480

gacaacaagg agtacgagta cagcgtcgaa tgtcaggagg acagcgcctg tcccgccgct      540

gaagagagcc tgcctatcga ggtgatggtg gacgccgtgc acaaactgaa gtatgagaat      600

tacacctcca gcttcttcat cagggacatc atcaaacccg atccccccaa gaacctgcag      660

ctgaagcctc tgaagaacag cagacaggtc gaagtgtcct gggagtaccc tgatacctgg      720

tccacacccc acagctactt cagcctgacc ttttgcgtgc aggtgcaggg caagagcaaa      780

agggagaaga aggacagggt gtttaccgac aagacctccg ccacagtgat ttgcagaaag      840

aacgcctcca tcagcgtgag ggcccaggac aggtattaca gcagctcctg gagcgaatgg      900

gctagcgtgc cctgtagc                                                    918


<210>  475
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  475

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  476
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  476

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Gly Val Gln Val Glu Thr Ile Ser Pro 
            260                 265                 270         


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
        275                 280                 285             


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp 
    290                 295                 300                 


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
305                 310                 315                 320 


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
                325                 330                 335     


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
            340                 345                 350         


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
        355                 360                 365             


Pro Glu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    370                 375                 380                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
385                 390                 395                 400 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                405                 410                 415     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            420                 425                 430         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        435                 440                 445             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    450                 455                 460                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
465                 470                 475                 480 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                485                 490                 495     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            500                 505                 510         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        515                 520                 525             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    530                 535                 540                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
545                 550                 555                 560 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                565                 570                 575     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            580                 585                 590         


Arg 
    


<210>  477
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  477

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Ile Ser Leu Ile Ala Ala Leu Ala Val 
            260                 265                 270         


Asp Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala 
        275                 280                 285             


Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met 
    290                 295                 300                 


Gly Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys 
305                 310                 315                 320 


Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr Asp Asp Arg Val Thr Trp 
                325                 330                 335     


Val Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu 
            340                 345                 350         


Ile Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys 
        355                 360                 365             


Ala Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp 
    370                 375                 380                 


Thr His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser 
385                 390                 395                 400 


Glu Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu 
                405                 410                 415     


Ile Leu Glu Arg Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
            420                 425                 430         


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
        435                 440                 445             


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
    450                 455                 460                 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                485                 490                 495     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            500                 505                 510         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        515                 520                 525             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    530                 535                 540                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
545                 550                 555                 560 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                565                 570                 575     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            580                 585                 590         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        595                 600                 605             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    610                 615                 620                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
625                 630                 635                 640 


Leu Pro Pro Arg 
                


<210>  478
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  478

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
305                 310                 315                 320 


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
                325                 330                 335     


Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys 
            340                 345                 350         


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
        355                 360                 365             


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
    370                 375                 380                 


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
385                 390                 395                 400 


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Pro Glu Ile 
                405                 410                 415     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            420                 425                 430         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        435                 440                 445             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    450                 455                 460                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
465                 470                 475                 480 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
                485                 490                 495     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            500                 505                 510         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        515                 520                 525             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    530                 535                 540                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
545                 550                 555                 560 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                565                 570                 575     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            580                 585                 590         


Arg 
    


<210>  479
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  479

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val 
305                 310                 315                 320 


Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala 
                325                 330                 335     


Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His 
            340                 345                 350         


Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile 
        355                 360                 365             


Leu Ser Ser Gln Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser 
    370                 375                 380                 


Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val 
385                 390                 395                 400 


Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys 
                405                 410                 415     


Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe 
            420                 425                 430         


Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His 
        435                 440                 445             


Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu 
    450                 455                 460                 


Arg Arg Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
465                 470                 475                 480 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                485                 490                 495     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            500                 505                 510         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        515                 520                 525             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    530                 535                 540                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
545                 550                 555                 560 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                565                 570                 575     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            580                 585                 590         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        595                 600                 605             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    610                 615                 620                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
625                 630                 635                 640 


Leu Pro Pro Arg 
                


<210>  480
<211>  649
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  480

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Ile Ser Leu Ile Ala 
                485                 490                 495     


Ala Leu Ala Val Asp His Val Ile Gly Met Glu Asn Ala Met Pro Trp 
            500                 505                 510         


Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys 
        515                 520                 525             


Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu 
    530                 535                 540                 


Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr Asp Asp 
545                 550                 555                 560 


Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly 
                565                 570                 575     


Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Tyr Glu Gln 
            580                 585                 590         


Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu 
        595                 600                 605             


Val Glu Gly Asp Thr His Phe Pro Asp Tyr Lys Pro Asp Asp Trp Glu 
    610                 615                 620                 


Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser His Ser 
625                 630                 635                 640 


Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
                645                 


<210>  481
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  481

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Gly Val Gln Val Glu 
                485                 490                 495     


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            500                 505                 510         


Cys Val Val His Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys Val Asp 
        515                 520                 525             


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    530                 535                 540                 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
545                 550                 555                 560 


Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                565                 570                 575     


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            580                 585                 590         


Glu Leu Leu Glu Leu Glu 
        595             


<210>  482
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  482

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Val Gly Ser Leu Asn 
                485                 490                 495     


Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp 
            500                 505                 510         


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met 
        515                 520                 525             


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
    530                 535                 540                 


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly 
545                 550                 555                 560 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
                565                 570                 575     


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
            580                 585                 590         


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
        595                 600                 605             


Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu 
    610                 615                 620                 


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
625                 630                 635                 640 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
                645                 650                 655     


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
            660                 665                 670         


Tyr Glu Lys Asn Asp 
        675         


<210>  483
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  483

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Val Gly Ser Leu Asn 
                485                 490                 495     


Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp 
            500                 505                 510         


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met 
        515                 520                 525             


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
    530                 535                 540                 


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly 
545                 550                 555                 560 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
                565                 570                 575     


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
            580                 585                 590         


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
        595                 600                 605             


Ser Ser Val Ile Lys Glu Phe Met Asn His Pro Gly His Leu Lys Leu 
    610                 615                 620                 


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
625                 630                 635                 640 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
                645                 650                 655     


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
            660                 665                 670         


Tyr Glu Lys Asn Asp 
        675         


<210>  484
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  484

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Val Gly Ser Leu Asn 
                485                 490                 495     


Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp 
            500                 505                 510         


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Lys Arg Met 
        515                 520                 525             


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
    530                 535                 540                 


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly 
545                 550                 555                 560 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
                565                 570                 575     


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
            580                 585                 590         


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
        595                 600                 605             


Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu 
    610                 615                 620                 


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
625                 630                 635                 640 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
                645                 650                 655     


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
            660                 665                 670         


Tyr Glu Lys Asn Asp 
        675         


<210>  485
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  485

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Val Gly Ser Leu Asn 
                485                 490                 495     


Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp 
            500                 505                 510         


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Phe Arg Met 
        515                 520                 525             


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
    530                 535                 540                 


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Phe Arg Pro Leu Lys Gly 
545                 550                 555                 560 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
                565                 570                 575     


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
            580                 585                 590         


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
        595                 600                 605             


Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu 
    610                 615                 620                 


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
625                 630                 635                 640 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
                645                 650                 655     


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
            660                 665                 670         


Tyr Glu Lys Asn Asp 
        675         


<210>  486
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  486

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gly Gly Val Gln Val Glu Thr Ile Ser Pro 
            20                  25                  30          


Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His 
        35                  40                  45              


Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp 
    50                  55                  60                  


Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg 
65                  70                  75                  80  


Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys 
                85                  90                  95      


Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly 
            100                 105                 110         


Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys 
        115                 120                 125             


Pro Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser Lys Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His 
            180                 185                 190         


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
    210                 215                 220                 


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
            260                 265                 270         


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
        275                 280                 285             


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
    290                 295                 300                 


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
305                 310                 315                 320 


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
                325                 330                 335     


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
            340                 345                 350         


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
        355                 360                 365             


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    370                 375                 380                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
385                 390                 395                 400 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                405                 410                 415     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            420                 425                 430         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        435                 440                 445             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    450                 455                 460                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
465                 470                 475                 480 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                485                 490                 495     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            500                 505                 510         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        515                 520                 525             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    530                 535                 540                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
545                 550                 555                 560 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                565                 570                 575     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            580                 585                 590         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600                 605         


<210>  487
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  487

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gly Ile Ser Leu Ile Ala Ala Leu Ala Val 
            20                  25                  30          


Asp Tyr Val Ile Gly Met Glu Asn Ala Met Pro Trp Asn Leu Pro Ala 
        35                  40                  45              


Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu Asn Lys Pro Val Ile Met 
    50                  55                  60                  


Gly Arg His Thr Trp Glu Ser Ile Gly Arg Pro Leu Pro Gly Arg Lys 
65                  70                  75                  80  


Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr Asp Asp Arg Val Thr Trp 
                85                  90                  95      


Val Lys Ser Val Asp Glu Ala Ile Ala Ala Cys Gly Asp Val Pro Glu 
            100                 105                 110         


Ile Met Val Ile Gly Gly Gly Arg Val Ile Glu Gln Phe Leu Pro Lys 
        115                 120                 125             


Ala Gln Lys Leu Tyr Leu Thr His Ile Asp Ala Glu Val Glu Gly Asp 
    130                 135                 140                 


Thr His Phe Pro Asp Tyr Glu Pro Asp Asp Trp Glu Ser Val Phe Ser 
145                 150                 155                 160 


Glu Phe His Asp Ala Asp Ala Gln Asn Ser His Ser Tyr Cys Phe Glu 
                165                 170                 175     


Ile Leu Glu Arg Arg Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
            180                 185                 190         


Lys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
        195                 200                 205             


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys 
    210                 215                 220                 


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
225                 230                 235                 240 


Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
            260                 265                 270         


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
        275                 280                 285             


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln 
305                 310                 315                 320 


Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr 
                325                 330                 335     


Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile 
            340                 345                 350         


Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly 
        355                 360                 365             


Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile 
    370                 375                 380                 


Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
385                 390                 395                 400 


Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr 
                405                 410                 415     


Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            420                 425                 430         


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        435                 440                 445             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    450                 455                 460                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
465                 470                 475                 480 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                485                 490                 495     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            500                 505                 510         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        515                 520                 525             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    530                 535                 540                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
545                 550                 555                 560 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                565                 570                 575     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            580                 585                 590         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        595                 600                 605             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    610                 615                 620                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
625                 630                 635                 640 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                645                 650                 655     


Pro Arg 
        


<210>  488
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  488

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gly Val Gly Ser Leu Asn Cys Ile Val Ala 
            20                  25                  30          


Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro 
        35                  40                  45              


Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser 
    50                  55                  60                  


Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp 
65                  70                  75                  80  


Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu 
                85                  90                  95      


Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu 
            100                 105                 110         


Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu 
        115                 120                 125             


Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile 
    130                 135                 140                 


Lys Glu Phe Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg 
145                 150                 155                 160 


Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu 
                165                 170                 175     


Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val 
            180                 185                 190         


Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn 
        195                 200                 205             


Asp Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser Lys Asp Ile Gln 
    210                 215                 220                 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
225                 230                 235                 240 


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
                245                 250                 255     


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
            260                 265                 270         


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        275                 280                 285             


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
    290                 295                 300                 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
305                 310                 315                 320 


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
            340                 345                 350         


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
        355                 360                 365             


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
    370                 375                 380                 


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
385                 390                 395                 400 


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
                405                 410                 415     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            420                 425                 430         


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
        435                 440                 445             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
    450                 455                 460                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
465                 470                 475                 480 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                485                 490                 495     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            500                 505                 510         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        515                 520                 525             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    530                 535                 540                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
545                 550                 555                 560 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                565                 570                 575     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            580                 585                 590         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        595                 600                 605             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    610                 615                 620                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
625                 630                 635                 640 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                645                 650                 655     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            660                 665                 670         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 685     


<210>  489
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  489

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gly Val Gly Ser Leu Asn Cys Ile Val Ala 
            20                  25                  30          


Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro 
        35                  40                  45              


Pro Leu Arg Asn Glu Phe Arg Tyr Phe Lys Arg Met Thr Thr Thr Ser 
    50                  55                  60                  


Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp 
65                  70                  75                  80  


Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu 
                85                  90                  95      


Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu 
            100                 105                 110         


Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu 
        115                 120                 125             


Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile 
    130                 135                 140                 


Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg 
145                 150                 155                 160 


Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu 
                165                 170                 175     


Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val 
            180                 185                 190         


Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn 
        195                 200                 205             


Asp Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser Lys Asp Ile Gln 
    210                 215                 220                 


Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val 
225                 230                 235                 240 


Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp 
                245                 250                 255     


Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His Thr 
            260                 265                 270         


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
        275                 280                 285             


Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile 
    290                 295                 300                 


Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
305                 310                 315                 320 


Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly Pro 
            340                 345                 350         


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser 
        355                 360                 365             


Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro 
    370                 375                 380                 


Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr 
385                 390                 395                 400 


Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn 
                405                 410                 415     


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            420                 425                 430         


Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr 
        435                 440                 445             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr 
    450                 455                 460                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
465                 470                 475                 480 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                485                 490                 495     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
            500                 505                 510         


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
        515                 520                 525             


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
    530                 535                 540                 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
545                 550                 555                 560 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
                565                 570                 575     


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
            580                 585                 590         


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
        595                 600                 605             


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
    610                 615                 620                 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
625                 630                 635                 640 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
                645                 650                 655     


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
            660                 665                 670         


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 685     


<210>  490
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  490
gacatccaga tgacacagac cacaagctcc ctgtccgcct ctctgggcga cagagtgacc       60

atcagctgcc gggcctccca ggatatctct aagtatctga actggtacca gcagaagccc      120

gatggcacag tgaagctgct gatctatcac accagccgcc tgcactccgg agtgccttct      180

aggttcagcg gctccggctc tggcacagac tacagcctga ccatctccaa cctggagcag      240

gaggatatcg ccacctattt ctgccagcag ggcaatacac tgccttacac ctttggcggc      300

ggcacaaagc tggagatcac cggaggagga ggcagcggag gaggaggctc cggcggcggc      360

ggctctgagg tgaagctgca ggagtccgga ccaggcctgg tggcacctag ccagtccctg      420

tctgtgacat gtaccgtgtc cggcgtgtct ctgccagact acggcgtgtc ttggatcagg      480

cagccaccta ggaagggcct ggagtggctg ggcgtgatct ggggcagcga gacaacatac      540

tataattctg ccctgaagag cagactgaca atcatcaagg acaacagcaa gtcccaggtg      600

ttcctgaaga tgaatagcct gcagacagac gataccgcca tctactattg cgccaagcac      660

tactattacg gcggcagcta tgccatggat tactggggcc agggcacatc cgtgaccgtg      720

tctagc                                                                 726


<210>  491
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  491
gacatccaga tgacacagac cacaagctcc ctgagcgcct ccctgggcga cagagtgacc       60

atctcttgcc gggccagcca ggatatctcc aagtatctga actggtacca gcagaagccc      120

gatggcacag tgaagctgct gatctatcac acctctcgcc tgcacagcgg cgtgccttcc      180

aggttctctg gcagcggctc cggcacagac tactctctga ccatcagcaa cctggagcag      240

gaggatatcg ccacctattt ctgccagcag ggcaatacac tgccctacac ctttggcggc      300

ggcacaaagc tggagatcac cggcggcggc ggctctggag gaggaggcag cggcggagga      360

ggctccgagg tgaagctgca ggagtccgga ccaggcctgg tggcaccatc tcagagcctg      420

tccgtgacat gtaccgtgag cggcgtgtcc ctgcctgact acggcgtgag ctggatcaga      480

cagccaccta ggaagggcct ggagtggctg ggcgtgatct ggggctccga gacaacatac      540

tataactccg ccctgaagtc tcggctgacc atcatcaagg acaactctaa gagccaggtg      600

ttcctgaaga tgaattccct gcagacagac gataccgcca tctactattg cgccaagcac      660

tactattacg gcggctccta tgccatggat tactggggcc agggcacatc tgtgaccgtg      720

tctagc                                                                 726


<210>  492
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  492
gacatccaga tgacacagac cacaagctcc ctgagcgcct ccctgggcga cagagtgacc       60

atcagctgcc gggcctccca ggatatctct aagtatctga actggtacca gcagaagcca      120

gatggcacag tgaagctgct gatctatcac accagccgcc tgcactccgg agtgccctct      180

aggttctctg gcagcggctc cggcacagac tacagcctga ccatctccaa cctggagcag      240

gaggatatcg ccacctattt ctgccagcag ggcaatacac tgccatacac ctttggcggc      300

ggcacaaagc tggagatcac cggaggagga ggcagcggag gaggaggctc cggcggcggc      360

ggctctgagg tgaagctgca ggagtccgga ccaggcctgg tggcaccttc tcagagcctg      420

tccgtgacat gtaccgtgtc tggcgtgagc ctgcccgact acggcgtgtc ttggatcaga      480

cagccaccta ggaagggcct ggagtggctg ggcgtgatct ggggcagcga gacaacatac      540

tataattctg ccctgaagag caggctgacc atcatcaagg acaactctaa gagccaggtg      600

ttcctgaaga tgaattccct gcagacagac gataccgcca tctactattg cgccaagcac      660

tactattacg gcggctctta tgccatggat tactggggcc agggcacaag cgtgaccgtg      720

tctagc                                                                 726


<210>  493
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  493
gacatccaga tgacacagac cacaagctcc ctgagcgcct ccctgggcga cagagtgacc       60

atctcttgcc gggccagcca ggatatctcc aagtatctga actggtacca gcagaagcca      120

gatggcacag tgaagctgct gatctatcac acctctcgcc tgcacagcgg agtgccctcc      180

aggttctctg gcagcggctc cggcacagac tactctctga ccatcagcaa cctggagcag      240

gaggatatcg ccacctattt ctgccagcag ggcaatacac tgccctacac ctttggcggc      300

ggcacaaagc tggagatcac cggcggcggc ggctctggag gaggaggcag cggcggagga      360

ggctccgagg tgaagctgca ggagtccgga ccaggcctgg tggcaccatc tcagagcctg      420

tccgtgacat gtaccgtgag cggcgtgtcc ctgcctgact acggcgtgag ctggatcaga      480

cagccaccta ggaagggcct ggagtggctg ggcgtgatct ggggctccga gacaacatac      540

tataattccg ccctgaagtc tcggctgaca atcatcaagg acaactctaa gagccaggtg      600

tttctgaaga tgaatagcct gcagacagac gataccgcca tctactattg cgccaagcac      660

tactattacg gcggctccta tgccatggat tactggggcc agggcacatc tgtgaccgtg      720

tctagc                                                                 726


<210>  494
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic CD19 scFv sequence

<400>  494
gacatccaga tgacacagac cacaagctcc ctgagcgcct ccctgggcga cagagtgacc       60

atcagctgcc gggcctccca ggatatctct aagtatctga actggtacca gcagaagcca      120

gatggcacag tgaagctgct gatctatcac accagccgcc tgcactccgg agtgccctct      180

aggttctctg gcagcggctc cggcacagac tacagcctga ccatctccaa cctggagcag      240

gaggatatcg ccacctattt ctgccagcag ggcaatacac tgccatacac ctttggcggc      300

ggcacaaagc tggagatcac cggaggagga ggcagcggag gaggaggctc cggcggcggc      360

ggctctgagg tgaagctgca ggagtccgga ccaggcctgg tggcaccttc tcagagcctg      420

tccgtgacat gtaccgtgtc tggcgtgagc ctgcccgact acggcgtgtc ttggatcaga      480

cagccaccta ggaagggcct ggagtggctg ggcgtgatct ggggcagcga gacaacatac      540

tataattctg ccctgaagag caggctgaca atcatcaagg acaactctaa gagccaggtg      600

tttctgaaga tgaatagcct gcagacagac gataccgcca tctactattg tgccaagcac      660

tactattacg gcggcagcta tgccatggat tactggggcc agggcacatc cgtgaccgtg      720

tctagc                                                                 726


<210>  495
<211>  207
<212>  DNA
<213>  Homo sapiens

<400>  495
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcacttt actgccc                                          207


<210>  496
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  496
accacaaccc cagcacctcg cccaccaaca ccagcaccaa ccatcgcatc ccagccactg       60

tctctgaggc ccgaggcatg taggcctgca gcaggaggcg ccgtgcacac caggggcctg      120

gactttgcct gcgat                                                       135


<210>  497
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  497
acaacaaccc cagcacccag acctccaaca cctgcaccaa ccatcgcaag ccagcctctg       60

tccctgaggc ccgaggcatg taggccagca gcaggaggcg ccgtgcacac ccggggcctg      120

gactttgcct gcgat                                                       135


<210>  498
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  498
accacaaccc cagcaccccg cccaccaaca cctgcaccaa ccatcgcctc ccagccactg       60

tctctgaggc ccgaggcatg taggcctgca gcaggaggcg ccgtgcacac caggggcctg      120

gactttgcct gcgat                                                       135


<210>  499
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  499
accacaaccc cagcacccag accaccaaca cctgcaccaa ccatcgcaag ccagcctctg       60

tccctgcgcc cagaggcatg caggccagca gcaggaggag cagtgcacac ccggggcctg      120

gacttcgcat gtgat                                                       135


<210>  500
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  500
accacaaccc cagcacctcg cccaccaaca ccagcaccaa ccatcgcatc ccagccactg       60

tctctgcgcc ccgaggcatg caggcctgca gcaggcggcg ccgtgcacac caggggcctg      120

gacttcgcct gtgat                                                       135


<210>  501
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  501
agggtgaagt tttctaggag cgccgatgca ccagcatata agcagggaca gaaccagctg       60

tacaacgagc tgaatctggg caggagagag gagtacgacg tgctggataa gaggagggga      120

agggaccccg agatgggagg caagccaagg agaaagaacc cccaggaggg cctgtataat      180

gagctgcaga aggacaagat ggccgaggcc tactccgaga tcggcatgaa gggagagcgg      240

cgcaggggca agggacacga tggcctgtat cagggcctgt ctacagccac caaggacacc      300

tacgatgcac tgcacatgca ggccctgcct ccaagg                                336


<210>  502
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  502
agggtgaagt tttccaggtc tgccgatgcc cccgcctata agcagggcca gaatcagctg       60

tacaacgagc tgaatctggg caggagagag gagtacgacg tgctggataa gaggagggga      120

cgcgaccccg agatgggagg caagcctagg agaaagaacc cacaggaggg cctgtataat      180

gagctgcaga aggacaagat ggccgaggcc tactctgaga tcggcatgaa gggagagcgg      240

cgcaggggca agggacacga tggcctgtat cagggcctga gcacagccac caaggacacc      300

tacgatgcac tgcacatgca ggccctgcca cctagg                                336


<210>  503
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  503
agggtgaagt ttagcaggtc cgccgatgcc ccagcctata agcagggcca gaaccagctg       60

tacaacgagc tgaatctggg caggagggaa gagtacgacg tgctggataa gaggagagga      120

agggaccccg agatgggagg caagccaagg aggaagaacc cacaggaggg cctgtataat      180

gagctgcaga aggacaagat ggccgaggcc tacagcgaga tcggcatgaa gggagagagg      240

agacggggca agggacacga tggcctgtat cagggcctgt ccacagccac caaggacacc      300

tacgatgcac tgcacatgca ggccctgcct ccaagg                                336


<210>  504
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  504
agggtgaagt tttccaggtc tgccgatgcc ccagcctata agcagggcca gaatcagctg       60

tacaacgagc tgaatctggg caggagagag gagtacgacg tgctggataa gaggagggga      120

cgcgaccccg agatgggagg caagcctagg agaaagaacc cacaggaggg cctgtataat      180

gagctgcaga aggacaagat ggccgaggcc tactctgaga tcggcatgaa gggagagcgg      240

cgcaggggca agggacacga tggcctgtat cagggcctga gcacagccac caaggacacc      300

tacgatgcac tgcacatgca ggccctgcca cctagg                                336


<210>  505
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  505
agggtgaagt ttagcaggtc cgccgatgcc ccagcctata agcagggcca gaaccagctg       60

tacaacgagc tgaatctggg caggagggaa gagtacgacg tgctggataa gaggagagga      120

agggaccccg agatgggagg caagccaagg aggaagaacc cacaggaggg cctgtataat      180

gagctgcaga aggacaagat ggccgaggcc tactccgaga tcggcatgaa gggagagagg      240

agacggggca agggacacga tggcctgtat cagggcctgt ctacagccac caaggacacc      300

tacgatgcac tgcacatgca ggccctgcct ccaagg                                336


<210>  506
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  506
aagagaggcc ggaagaagct gctgtacatc ttcaagcagc ccttcatgag gcccgtgcag       60

acaacccagg aggaggacgg ctgcagctgt cggttcccag aggaggagga gggaggatgt      120

gagctg                                                                 126


<210>  507
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  507
aagcgcggca ggaagaagct gctgtacatc ttcaagcagc cctttatgcg ccctgtgcag       60

acaacccagg aggaggacgg ctgcagctgt aggttcccag aggaggagga gggaggatgt      120

gagctg                                                                 126


<210>  508
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  508
aagcgcggca ggaagaagct gctgtacatc ttcaagcagc cttttatgcg cccagtgcag       60

acaacccagg aggaggacgg ctgcagctgt aggttccctg aggaggagga gggaggatgt      120

gagctg                                                                 126


<210>  509
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  509
aagcgcggca ggaagaagct gctgtacatc ttcaagcagc cctttatgcg ccctgtgcag       60

acaacccagg aggaggacgg ctgcagctgt aggttccctg aggaggagga gggaggatgt      120

gagctg                                                                 126


<210>  510
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  510
aagcgcggca ggaagaagct gctgtacatc ttcaagcagc cttttatgcg cccagtgcag       60

acaacccagg aggaggacgg ctgcagctgt aggttccctg aggaggagga gggaggatgc      120

gagctg                                                                 126


<210>  511
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  511
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  512
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  512
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

ccc                                                                     63


<210>  513
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  513
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cct                                                                     63


<210>  514
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  514
atggcactgc ctgtgacagc cctgctgctg ccactggccc tgctgctgca cgcagcccgc       60

cct                                                                     63


<210>  515
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  515
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagcccgc       60

cct                                                                     63


<210>  516
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  516
ggaggcagcg gagga                                                        15


<210>  517
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  517
ggaggctctg gagga                                                        15


<210>  518
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  518
ggaggctccg gcgga                                                        15


<210>  519
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  519
ggaggatccg gaggc                                                        15


<210>  520
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  520
ggaggatctg gagga                                                        15


<210>  521
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Cleavage site

<400>  521
gagtctaggc gcgtgcggag aaataagcgg agcaag                                 36


<210>  522
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Cleavage site

<400>  522
gagtctcgga gagtgaggcg caataagagg agcaag                                 36


<210>  523
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Cleavage site

<400>  523
gagtccagga gagtgcggcg caacaagagg agcaag                                 36


<210>  524
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  524
ggagtgcagg tggagacaat ctctcctggc gatggccgga ccttcccaaa gagaggccag       60

acatgcgtgg tgcactacac cggcatgctg gaggacggca agaaggtgga cagctcccgg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc tgtgggccag agagccaagc tgacaatcag ccctgattac      240

gcatatggag caaccggaca cccaggaatc atcccacctc acgccaccct ggtgtttgat      300

gtggagctgc tgaagccaga g                                                321


<210>  525
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  525
ggcgtgcagg tggagacaat ctcccctggc gatggccgga ccttcccaaa gagaggccag       60

acatgcgtgg tgcactacac cggcatgctg gaggacggca agaaggtgga cagctcccgg      120

gatagaaaca agcctttcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc tgtgggccag agagccaagc tgacaatcag ccctgattac      240

gcatatggag caaccggaca cccaggaatc atcccacctc acgccaccct ggtgtttgac      300

gtggagctgc tgaagccaga g                                                321


<210>  526
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  526
ggagtgcagg tggagacaat ctcccctggc gatggcagga ccttcccaaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg gaggacggca agaaggtgga cagctcccgg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag cgcgccaagc tgacaatctc tcctgattac      240

gcatatggag caaccggaca cccaggaatc atcccacctc acgccaccct ggtgtttgac      300

gtggagctgc tgaagcccga g                                                321


<210>  527
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  527
atctctctga tcgccgccct ggccgtggat tacgtgatcg gcatggagaa cgccatgcca       60

tggaatctgc cagcagacct ggcatggttc aagaggaaca cactgaataa gccagtgatc      120

atgggcagac acacctggga gtccatcggc cggccactgc caggcagaaa gaacatcatc      180

ctgagctccc agcccggcac agacgatagg gtgacctggg tgaagagcgt ggacgaggca      240

atcgcagcat gcggcgatgt gcctgagatc atggtcatcg gaggaggacg cgtgatcgag      300

cagttcctgc caaaggccca gaagctgtac ctgacacaca tcgatgccga ggtggagggc      360

gacacccact ttcctgatta tgagccagac gattgggagt ccgtgttctc tgagtttcac      420

gacgccgatg cccagaactc tcacagctat tgttttgaga tcctggagcg gaga            474


<210>  528
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  528
ggcgtgcagg tggagacaat cagccccggc gatggccgga cctttcctaa gagaggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctccagg      120

gatcgcaata agcccttcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgacaatctc tccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga gtga                                             324


<210>  529
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  529
ggagtgcagg tggagacaat cagccccggc gatggcagga cctttcctaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctcccgg      120

gatagaaata agcccttcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      180

gagggagtgg cacagatgtc tgtgggacag ggcgccaagc tgacaatcag cccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga gtga                                             324


<210>  530
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  530
ggcgtgcagg tggagacaat cagccccggc gatggccgga cctttcctaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctccagg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgacaatctc tccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga gtga                                             324


<210>  531
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  531
ggagtgcagg tggagacaat cagcccaggc gacggaagga cattcccaaa gaggggacag       60

acctgcgtgg tgcactacac aggcatgctg ggcgatggca agaaggtgga cagctcccgg      120

gatagaaaca agcccttcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgaccatctc tcctgactac      240

gcctatggag caacaggaca cccaggaatc atcccacctc acgccaccct ggtgtttgat      300

gtggagctgc tggagctgga gtga                                             324


<210>  532
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  532
atctccctga tcgccgccct ggccgtggat tatgtgatcg gcatggagaa cgccatgccc       60

tggaatctgc ccgccgacct ggcctggttc aagaggaata ccctgaacaa gcccgtcatc      120

atgggcaggc acacctggga aagcatcggc agacccctgc ccggcaggaa gaacatcatc      180

ctgtccagcc agcccggcac cgacgacaga gtgacctggg tgaagagcgt ggacgaagct      240

atcgccgctt gcggcgacgt gcccgagatc atggtgatcg gcggcggcag ggtgatcgaa      300

cagttcctgc ccaaggccca gaagctgtac ctgacccaca tcgatgccga ggtggaaggc      360

gatacacact tccccgatta cgaacctgac gactgggaaa gcgtgttttc cgaattccac      420

gacgccgacg cccagaacag ccacagctac tgcttcgaga tcctggaaag aagg            474


<210>  533
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  533
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  534
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  534
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  535
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  535
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aattcatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  536
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  536
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttcagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagt tcatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgattg a                                                561


<210>  537
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  537
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttcaagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  538
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  538
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttaagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgattg a                                                561


<210>  539
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  539
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttcaagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agttccgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  540
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  540
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttttcaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaagt tccgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgattg a                                                561


<210>  541
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  541
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggtg a                                               1461


<210>  542
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  542
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cctgacatcc agatgacaca gaccacaagc tccctgagcg cctccctggg cgacagagtg      120

accatctctt gccgggccag ccaggatatc tccaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacacctctc gcctgcacag cggcgtgcct      240

tccaggttct ctggcagcgg ctccggcaca gactactctc tgaccatcag caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcccta cacctttggc      360

ggcggcacaa agctggagat caccggcggc ggcggctctg gaggaggagg cagcggcgga      420

ggaggctccg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc atctcagagc      480

ctgtccgtga catgtaccgt gagcggcgtg tccctgcctg actacggcgt gagctggatc      540

agacagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggctc cgagacaaca      600

tactataact ccgccctgaa gtctcggctg accatcatca aggacaactc taagagccag      660

gtgttcctga agatgaattc cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggctc ctatgccatg gattactggg gccagggcac atctgtgacc      780

gtgtctagcg gcgtgcaggt ggagacaatc agcccaggcg acggacgcac ctttccaaag      840

aggggacaga catgcgtggt gcactacacc ggcatgctgg aggatggcaa gaaggtggac      900

tcctctagag atcggaataa gccattcaag tttatgctgg gcaagcagga agtgatcaga      960

ggctgggagg agggagtggc acagatgtct gtgggacagc gggccaagct gacaatcagc     1020

cctgactatg catacggagc aaccggacac ccaggaatca tcccaccaca cgccacactg     1080

gtgttcgatg tggagctgct gaagcctgag acaacaaccc cagcacccag acctccaaca     1140

cctgcaccaa ccatcgcaag ccagcctctg tccctgaggc ccgaggcatg taggccagca     1200

gcaggaggcg ccgtgcacac ccggggcctg gactttgcct gcgatatcta tatctgggca     1260

ccactggcag gaacatgtgg cgtgctgctg ctgtccctgg tcatcaccct gtattgcaag     1320

cgcggcagga agaagctgct gtacatcttc aagcagccct ttatgcgccc tgtgcagaca     1380

acccaggagg aggacggctg cagctgtagg ttcccagagg aggaggaggg aggatgtgag     1440

ctgagggtga agttttccag gtctgccgat gcccccgcct ataagcaggg ccagaatcag     1500

ctgtacaacg agctgaatct gggcaggaga gaggagtacg acgtgctgga taagaggagg     1560

ggacgcgacc ccgagatggg aggcaagcct aggagaaaga acccacagga gggcctgtat     1620

aatgagctgc agaaggacaa gatggccgag gcctactctg agatcggcat gaagggagag     1680

cggcgcaggg gcaagggaca cgatggcctg tatcagggcc tgagcacagc caccaaggac     1740

acctacgatg cactgcacat gcaggccctg ccacctaggt ga                        1782


<210>  543
<211>  1935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  543
atggcactgc ctgtgacagc cctgctgctg ccactggccc tgctgctgca cgcagcccgc       60

cctgacatcc agatgacaca gaccacaagc tccctgagcg cctccctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

ccagatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgccc      240

tctaggttct ctggcagcgg ctccggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgccata cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc ttctcagagc      480

ctgtccgtga catgtaccgt gtctggcgtg agcctgcccg actacggcgt gtcttggatc      540

agacagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcaggctg accatcatca aggacaactc taagagccag      660

gtgttcctga agatgaattc cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggctc ttatgccatg gattactggg gccagggcac aagcgtgacc      780

gtgtctagca tctccctgat cgccgccctg gcagtggact acgtgatcgg catggagaac      840

gccatgccct ggaatctgcc tgccgatctg gcctggttta agagaaacac actgaataag      900

cccgtgatca tgggccggca cacctgggag tctatcggca ggcccctgcc tggcaggaag      960

aacatcatcc tgtcctctca gcctggcaca gacgatagag tgacctgggt gaagagcgtg     1020

gacgaggcaa tcgcagcatg tggcgatgtg cccgagatca tggtcatcgg cggcggcaga     1080

gtgatcgagc agttcctgcc taaggcccag aagctgtatc tgacacacat cgacgccgag     1140

gtggagggcg acacccactt tccagattac gagcccgacg attgggagtc cgtgttctct     1200

gagtttcacg acgccgatgc ccagaattcc cactcttatt gcttcgagat cctggagagg     1260

agaaccacaa ccccagcacc ccgcccacca acacctgcac caaccatcgc ctcccagcca     1320

ctgtctctga ggcccgaggc atgtaggcct gcagcaggag gcgccgtgca caccaggggc     1380

ctggactttg cctgcgatat ctacatctgg gcacctctgg caggaacatg tggcgtgctg     1440

ctgctgtccc tggtcatcac cctgtattgc aagcgcggca ggaagaagct gctgtacatc     1500

ttcaagcagc cttttatgcg cccagtgcag acaacccagg aggaggacgg ctgcagctgt     1560

aggttccctg aggaggagga gggaggatgt gagctgaggg tgaagtttag caggtccgcc     1620

gatgccccag cctataagca gggccagaac cagctgtaca acgagctgaa tctgggcagg     1680

agggaagagt acgacgtgct ggataagagg agaggaaggg accccgagat gggaggcaag     1740

ccaaggagga agaacccaca ggagggcctg tataatgagc tgcagaagga caagatggcc     1800

gaggcctaca gcgagatcgg catgaaggga gagaggagac ggggcaaggg acacgatggc     1860

ctgtatcagg gcctgtccac agccaccaag gacacctacg atgcactgca catgcaggcc     1920

ctgcctccaa ggtga                                                      1935


<210>  544
<211>  1782
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  544
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

cctgacatcc agatgacaca gaccacaagc tccctgagcg cctccctggg cgacagagtg      120

accatctctt gccgggccag ccaggatatc tccaagtatc tgaactggta ccagcagaag      180

ccagatggca cagtgaagct gctgatctat cacacctctc gcctgcacag cggagtgccc      240

tccaggttct ctggcagcgg ctccggcaca gactactctc tgaccatcag caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcccta cacctttggc      360

ggcggcacaa agctggagat caccggcggc ggcggctctg gaggaggagg cagcggcgga      420

ggaggctccg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc atctcagagc      480

ctgtccgtga catgtaccgt gagcggcgtg tccctgcctg actacggcgt gagctggatc      540

agacagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggctc cgagacaaca      600

tactataatt ccgccctgaa gtctcggctg acaatcatca aggacaactc taagagccag      660

gtgtttctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggctc ctatgccatg gattactggg gccagggcac atctgtgacc      780

gtgtctagca ccacaacccc agcacccaga ccaccaacac ctgcaccaac catcgcaagc      840

cagcctctgt ccctgcgccc agaggcatgc aggccagcag caggaggagc agtgcacacc      900

cggggcctgg acttcgcatg tgatggagtg caggtggaga caatctcccc aggcgacggc      960

agaacctttc ccaagcgggg ccagacatgc gtggtgcact ataccggcat gctggaggat     1020

ggcaagaagg tggactcctc tagagatcgg aacaagccat tcaagtttat gctgggcaag     1080

caggaagtga tcagaggctg ggaggaggga gtggcacaga tgtctgtggg acagcgggcc     1140

aagctgacaa tcagcccaga ctatgcatac ggagcaaccg gacaccctgg aatcatccct     1200

ccacacgcca ccctggtgtt cgatgtggag ctgctgaagc ctgagatcta catctgggca     1260

ccactggcag gaacatgcgg cgtgctgctg ctgtccctgg tcatcaccct gtattgtaag     1320

cgcggcagga agaagctgct gtacatcttc aagcagccct ttatgcgccc tgtgcagaca     1380

acccaggagg aggacggctg cagctgtagg ttccctgagg aggaggaggg aggatgtgag     1440

ctgagggtga agttttccag gtctgccgat gccccagcct ataagcaggg ccagaatcag     1500

ctgtacaacg agctgaatct gggcaggaga gaggagtacg acgtgctgga taagaggagg     1560

ggacgcgacc ccgagatggg aggcaagcct aggagaaaga acccacagga gggcctgtat     1620

aatgagctgc agaaggacaa gatggccgag gcctactctg agatcggcat gaagggagag     1680

cggcgcaggg gcaagggaca cgatggcctg tatcagggcc tgagcacagc caccaaggac     1740

acctacgatg cactgcacat gcaggccctg ccacctaggt ga                        1782


<210>  545
<211>  1935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  545
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagcccgc       60

cctgacatcc agatgacaca gaccacaagc tccctgagcg cctccctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

ccagatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgccc      240

tctaggttct ctggcagcgg ctccggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgccata cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc ttctcagagc      480

ctgtccgtga catgtaccgt gtctggcgtg agcctgcccg actacggcgt gtcttggatc      540

agacagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcaggctg acaatcatca aggacaactc taagagccag      660

gtgtttctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgtgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgcgccc cgaggcatgc aggcctgcag caggcggcgc cgtgcacacc      900

aggggcctgg acttcgcctg tgatatctcc ctgatcgccg ccctggcagt ggactacgtg      960

atcggcatgg agaacgccat gccctggaat ctgcctgccg atctggcctg gtttaagaga     1020

aacacactga ataagcccgt gatcatgggc cggcacacct gggagagcat cggcagacct     1080

ctgccaggcc ggaagaacat catcctgtcc tctcagcctg gcacagacga tagagtgacc     1140

tgggtgaagt ccgtggacga ggcaatcgca gcatgcggcg atgtgcccga gatcatggtc     1200

atcggcggcg gcagagtgat cgagcagttc ctgcctaagg cccagaagct gtatctgaca     1260

cacatcgacg ccgaggtgga gggcgacacc cactttccag attacgagcc cgacgattgg     1320

gagtccgtgt tctctgagtt tcacgacgcc gatgcccaga attcccactc ttattgtttc     1380

gagatcctgg agagaagaat ctacatctgg gcacctctgg caggaacatg cggcgtgctg     1440

ctgctgtctc tggtcatcac cctgtattgt aagcgcggca ggaagaagct gctgtacatc     1500

ttcaagcagc cttttatgcg cccagtgcag acaacccagg aggaggacgg ctgcagctgt     1560

aggttccctg aggaggagga gggaggatgc gagctgaggg tgaagtttag caggtccgcc     1620

gatgccccag cctataagca gggccagaac cagctgtaca acgagctgaa tctgggcagg     1680

agggaagagt acgacgtgct ggataagagg agaggaaggg accccgagat gggaggcaag     1740

ccaaggagga agaacccaca ggagggcctg tataatgagc tgcagaagga caagatggcc     1800

gaggcctact ccgagatcgg catgaaggga gagaggagac ggggcaaggg acacgatggc     1860

ctgtatcagg gcctgtctac agccaccaag gacacctacg atgcactgca catgcaggcc     1920

ctgcctccaa ggtga                                                      1935


<210>  546
<211>  1950
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  546
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggcagcgga ggaatctccc tgatcgccgc cctggcagtg     1500

gaccacgtga tcggcatgga gaacgccatg ccatggaatc tgcccgccga tctggcctgg     1560

ttcaagcgga acaccctgaa taagccagtg atcatgggca gacacacatg ggagtctatc     1620

ggcaggcccc tgcctggacg caagaacatc atcctgagct cccagcccgg caccgacgat     1680

agggtgacat gggtgaagtc cgtggacgag gcaatcgcag catgcggcga tgtgcccgag     1740

atcatggtca tcggcggcgg cagagtgtac gagcagttcc tgcctaaggc ccagaagctg     1800

tatctgaccc acatcgacgc cgaggtggag ggcgacacac actttcctga ttacaagcca     1860

gacgattggg agtccgtgtt ctctgagttt cacgacgccg atgcccagaa ttctcacagc     1920

tattgttttg agatcctgga gcggagatga                                      1950


<210>  547
<211>  1797
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  547
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggctctgga ggaggagtgc aggtggagac aatcagccca     1500

ggcgacggaa ggacattccc aaagagggga cagacctgcg tggtgcacta cacaggcatg     1560

ctgggcgatg gcaagaaggt ggacagctcc cgggatagaa acaagccctt caagtttatg     1620

ctgggcaagc aggaagtgat caggggatgg gaggagggag tggcacagat gtccgtggga     1680

cagggcgcca agctgaccat ctctcctgac tacgcctatg gagcaacagg acacccagga     1740

atcatcccac ctcacgccac cctggtgttt gatgtggagc tgctggagct ggagtga        1797


<210>  548
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  548
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggcagcgga ggagtgggct ccctgaactg catcgtggcc     1500

gtgagccaga acatgggcat cggcaagaat ggcgacctgc cttggccacc tctgaggaac     1560

gagttcagat actttcagag gatgaccaca accagctccg tggagggcaa gcagaacctg     1620

gtcatcatgg gcaagaagac atggttctct atccccgaga agaaccgccc tctgaagggc     1680

cggatcaatc tggtgctgag cagagagctg aaggagccac cacagggagc acacttcctg     1740

agccggagcc tggacgatgc cctgaagctg accgagcagc ccgagctggc caacaaggtg     1800

gacatggtgt ggatcgtggg cggctctagc gtgatcaagg aggccatgaa tcacccaggc     1860

cacctgaagc tgttcgtgac aagaatcatg caggactttg agtccgatac cttctttccc     1920

gagatcgacc tggagaagta caagctgctg cctgagtatc caggcgtgct gtctgatgtg     1980

caggaggaga agggcatcaa gtacaagttc gaggtgtatg agaagaatga ttga           2034


<210>  549
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  549
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggcagcgga ggagtgggct ccctgaactg catcgtggcc     1500

gtgagccaga acatgggcat cggcaagaat ggcgacctgc cttggccacc tctgaggaac     1560

gagttcagat actttcagag gatgaccaca accagctccg tggagggcaa gcagaacctg     1620

gtcatcatgg gcaagaagac atggttctct atccccgaga agaaccgccc tctgaagggc     1680

cggatcaatc tggtgctgag cagagagctg aaggagccac cacagggagc acacttcctg     1740

agccggagcc tggacgatgc cctgaagctg accgagcagc ccgagctggc caacaaggtg     1800

gacatggtgt ggatcgtggg cggctctagc gtgatcaagg agttcatgaa tcacccaggc     1860

cacctgaagc tgttcgtgac aagaatcatg caggactttg agtccgatac cttctttccc     1920

gagatcgacc tggagaagta caagctgctg cctgagtatc caggcgtgct gtctgatgtg     1980

caggaggaga agggcatcaa gtacaagttc gaggtgtatg agaagaatga ttga           2034


<210>  550
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  550
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggcagcgga ggagtgggct ccctgaactg catcgtggcc     1500

gtgagccaga acatgggcat cggcaagaat ggcgacctgc cttggccacc tctgaggaac     1560

gagttcagat actttaagag gatgaccaca accagctccg tggagggcaa gcagaacctg     1620

gtcatcatgg gcaagaagac atggttctct atccccgaga agaaccgccc tctgaagggc     1680

cggatcaatc tggtgctgag cagagagctg aaggagccac cacagggagc acacttcctg     1740

agccggagcc tggacgatgc cctgaagctg accgagcagc ccgagctggc caacaaggtg     1800

gacatggtgt ggatcgtggg cggctctagc gtgatcaagg aggccatgaa tcacccaggc     1860

cacctgaagc tgttcgtgac aagaatcatg caggactttg agtccgatac cttctttccc     1920

gagatcgacc tggagaagta caagctgctg cctgagtatc caggcgtgct gtctgatgtg     1980

caggaggaga agggcatcaa gtacaagttc gaggtgtatg agaagaatga ttga           2034


<210>  551
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  551
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggcagcgga ggagtgggct ccctgaactg catcgtggcc     1500

gtgagccaga acatgggcat cggcaagaat ggcgacctgc cttggccacc tctgaggaac     1560

gagttcagat actttttcag gatgaccaca accagctccg tggagggcaa gcagaacctg     1620

gtcatcatgg gcaagaagac atggttctct atccccgaga agttccgccc tctgaagggc     1680

cggatcaatc tggtgctgag cagagagctg aaggagccac cacagggagc acacttcctg     1740

agccggagcc tggacgatgc cctgaagctg accgagcagc ccgagctggc caacaaggtg     1800

gacatggtgt ggatcgtggg cggctctagc gtgatcaagg aggccatgaa tcacccaggc     1860

cacctgaagc tgttcgtgac aagaatcatg caggactttg agtccgatac cttctttccc     1920

gagatcgacc tggagaagta caagctgctg cctgagtatc caggcgtgct gtctgatgtg     1980

caggaggaga agggcatcaa gtacaagttc gaggtgtatg agaagaatga ttga           2034


<210>  552
<211>  1824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  552
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

ccttctggag gcgtgcaggt ggagacaatc agcccaggcg acggacgcac cttcccaaag      120

aggggacaga catgcgtggt gcactacacc ggcatgctgg aggatggcaa gaaggtggac      180

agctccagag atcggaacaa gccattcaag tttatgctgg gcaagcagga agtgatcaga      240

ggatgggagg agggagtggc acagatgagc gtgggacagc gggccaagct gacaatctcc      300

cctgactatg catacggagc aaccggacac ccaggaatca tcccacctca cgccacactg      360

gtgttcgacg tggagctgct gaagcctgag gagtccagga gagtgcggcg caacaagcgg      420

tctaaggata tccagatgac acagaccaca agctccctgt ccgcctctct gggcgacaga      480

gtgaccatca gctgccgggc ctcccaggat atctctaagt atctgaactg gtaccagcag      540

aagcccgatg gcacagtgaa gctgctgatc tatcacacca gccgcctgca ctccggagtg      600

ccttctaggt tcagcggctc cggctctggc acagactaca gcctgaccat ctccaacctg      660

gagcaggagg atatcgccac ctatttctgc cagcagggca atacactgcc ttacaccttt      720

ggcggcggca caaagctgga gatcaccgga ggaggaggca gcggaggagg aggctccggc      780

ggcggcggct ctgaggtgaa gctgcaggag tccggaccag gcctggtggc acctagccag      840

tccctgtctg tgacatgtac cgtgtccggc gtgtctctgc cagactacgg cgtgtcttgg      900

atcaggcagc cacctaggaa gggcctggag tggctgggcg tgatctgggg cagcgagaca      960

acatactata attctgccct gaagagcaga ctgacaatca tcaaggacaa cagcaagtcc     1020

caggtgttcc tgaagatgaa tagcctgcag acagacgata ccgccatcta ctattgcgcc     1080

aagcactact attacggcgg cagctatgcc atggattact ggggccaggg cacatccgtg     1140

accgtgtcta gcaccacaac cccagcacct cgcccaccaa caccagcacc aaccatcgca     1200

tcccagccac tgtctctgag gcccgaggca tgtaggcctg cagcaggagg cgccgtgcac     1260

accaggggcc tggactttgc ctgcgatatc tatatctggg caccactggc aggaacatgt     1320

ggcgtgctgc tgctgtccct ggtcatcacc ctgtattgca agagaggccg gaagaagctg     1380

ctgtacatct tcaagcagcc cttcatgagg cccgtgcaga caacccagga ggaggacggc     1440

tgcagctgtc ggttcccaga ggaggaggag ggaggatgtg agctgagggt gaagttttct     1500

aggagcgccg atgcaccagc atataagcag ggacagaacc agctgtacaa cgagctgaat     1560

ctgggcagga gagaggagta cgacgtgctg gataagagga ggggaaggga ccccgagatg     1620

ggaggcaagc caaggagaaa gaacccccag gagggcctgt ataatgagct gcagaaggac     1680

aagatggccg aggcctactc cgagatcggc atgaagggag agcggcgcag gggcaaggga     1740

cacgatggcc tgtatcaggg cctgtctaca gccaccaagg acacctacga tgcactgcac     1800

atgcaggccc tgcctccaag gtga                                            1824


<210>  553
<211>  1977
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  553
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

ccttctggaa tcagcctgat cgccgccctg gcagtggact acgtgatcgg catggagaac      120

gccatgccct ggaatctgcc tgccgatctg gcctggttca agagaaacac actgaataag      180

cccgtgatca tgggccggca cacctgggag tccatcggca ggcccctgcc tggcaggaag      240

aacatcatcc tgagctccca gcctggcaca gacgatagag tgacctgggt gaagagcgtg      300

gacgaggcaa tcgcagcatg cggcgatgtg cccgagatca tggtcatcgg cggcggcaga      360

gtgatcgagc agttcctgcc taaggcccag aagctgtatc tgacacacat cgacgccgag      420

gtggagggcg acacccactt tccagattac gagcccgacg attgggagtc cgtgttctct      480

gagtttcacg acgccgatgc ccagaacagc cactcctact gcttcgagat cctggagagg      540

agagagtctc ggcgcgtgag gagaaataag agaagcaagg acatccagat gacacagacc      600

acaagctccc tgtccgcctc tctgggcgac agagtgacca tcagctgccg ggcctcccag      660

gatatctcta agtatctgaa ctggtaccag cagaagcccg atggcacagt gaagctgctg      720

atctatcaca ccagccgcct gcactccgga gtgccttcta ggttcagcgg ctccggctct      780

ggcacagact acagcctgac catctccaac ctggagcagg aggatatcgc cacctatttc      840

tgccagcagg gcaatacact gccttacacc tttggcggcg gcacaaagct ggagatcacc      900

ggaggaggag gcagcggagg aggaggctcc ggcggcggcg gctctgaggt gaagctgcag      960

gagtccggac caggcctggt ggcacctagc cagtccctgt ctgtgacatg taccgtgtcc     1020

ggcgtgtctc tgccagacta cggcgtgtct tggatcaggc agccacctag gaagggcctg     1080

gagtggctgg gcgtgatctg gggcagcgag acaacatact ataattctgc cctgaagagc     1140

agactgacaa tcatcaagga caacagcaag tcccaggtgt tcctgaagat gaatagcctg     1200

cagacagacg ataccgccat ctactattgc gccaagcact actattacgg cggcagctat     1260

gccatggatt actggggcca gggcacatcc gtgaccgtgt ctagcaccac aaccccagca     1320

cctcgcccac caacaccagc accaaccatc gcatcccagc cactgtctct gaggcccgag     1380

gcatgtaggc ctgcagcagg aggcgccgtg cacaccaggg gcctggactt tgcctgcgat     1440

atctatatct gggcaccact ggcaggaaca tgtggcgtgc tgctgctgtc cctggtcatc     1500

accctgtatt gcaagagagg ccggaagaag ctgctgtaca tcttcaagca gcccttcatg     1560

aggcccgtgc agacaaccca ggaggaggac ggctgcagct gtcggttccc agaggaggag     1620

gagggaggat gtgagctgag ggtgaagttt tctaggagcg ccgatgcacc agcatataag     1680

cagggacaga accagctgta caacgagctg aatctgggca ggagagagga gtacgacgtg     1740

ctggataaga ggaggggaag ggaccccgag atgggaggca agccaaggag aaagaacccc     1800

caggagggcc tgtataatga gctgcagaag gacaagatgg ccgaggccta ctccgagatc     1860

ggcatgaagg gagagcggcg caggggcaag ggacacgatg gcctgtatca gggcctgtct     1920

acagccacca aggacaccta cgatgcactg cacatgcagg ccctgcctcc aaggtga        1977


<210>  554
<211>  2061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  554
atggcactgc cagtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagccaga       60

ccaagcggag tgggctccct gaactgcatc gtggccgtga gccagaacat gggcatcggc      120

aagaatggcg acctgccatg gccacctctg aggaacgagt tcaggtactt tcagagaatg      180

accacaacca gctccgtgga gggcaagcag aacctggtca tcatgggcaa gaagacctgg      240

ttcagcatcc ccgagaagaa caggcctctg aagggcagaa tcaatctggt gctgtccagg      300

gagctgaagg agccaccaca gggagcccac tttctgtctc gcagcctgga cgatgccctg      360

aagctgacag agcagcccga gctggccaac aaggtggata tggtgtggat cgtgggcggc      420

tctagcgtga tcaaggagtt catgaatcac cccggccacc tgaagctgtt cgtgaccagg      480

atcatgcagg actttgagtc cgatacattc tttcctgaga tcgacctgga gaagtataag      540

ctgctgccag agtaccccgg cgtgctgagc gatgtgcagg aggagaaggg catcaagtat      600

aagtttgagg tgtacgagaa gaacgacgag tctaggagag tgcggcgcaa taagagaagc      660

aaggacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      720

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      780

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      840

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      900

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      960

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc     1020

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc     1080

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc     1140

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca     1200

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag     1260

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag     1320

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc     1380

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc     1440

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc     1500

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc     1560

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1620

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1680

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1740

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1800

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1860

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1920

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1980

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     2040

caggccctgc ctccaaggtg a                                               2061


<210>  555
<211>  2061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  555
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

ccaagcggag tgggctccct gaactgcatc gtggccgtga gccagaacat gggcatcggc      120

aagaatggcg acctgccatg gccacctctg aggaacgagt tcaggtactt taagagaatg      180

accacaacca gctccgtgga gggcaagcag aacctggtca tcatgggcaa gaagacctgg      240

ttcagcatcc ccgagaagaa caggcctctg aagggcagaa tcaatctggt gctgtccagg      300

gagctgaagg agccaccaca gggagcccac tttctgtctc gcagcctgga cgatgccctg      360

aagctgacag agcagcccga gctggccaac aaggtggata tggtgtggat cgtgggcggc      420

tctagcgtga tcaaggaggc catgaatcac cccggccacc tgaagctgtt cgtgaccagg      480

atcatgcagg actttgagtc cgatacattc tttcctgaga tcgacctgga gaagtataag      540

ctgctgccag agtaccccgg cgtgctgagc gatgtgcagg aggagaaggg catcaagtat      600

aagttcgagg tgtacgagaa gaacgacgag tctaggagag tgcggcgcaa taagagaagc      660

aaggacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      720

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      780

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      840

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      900

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      960

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc     1020

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc     1080

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc     1140

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca     1200

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag     1260

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag     1320

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc     1380

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc     1440

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc     1500

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc     1560

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1620

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1680

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1740

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1800

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1860

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1920

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1980

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     2040

caggccctgc ctccaaggtg a                                               2061


<210>  556
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  556
aagcttggga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgactctact      600

aga                                                                    603


<210>  557
<211>  1339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  557
cgatagtaat tcatacaaaa ggactcgccc ctgccttggg gaatcccagg gaccgtcgtt       60

aaactcccac taacgtagaa cccagagatc gctgcgttcc cgccccctca cccgcccgct      120

ctcgtcatca ctgaggtgga gaagagcatg cgtgaggctc cggtgcccgt cagtgggcag      180

agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaaccggtg      240

cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt      300

ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc      360

gcaacgggtt tgccgccaga acacaggtaa gtgccgtgtg tggttcccgc gggcctggcc      420

tctttacggg ttatggccct tgcgtgcctt gaattacttc cacgcccctg gctgcagtac      480

gtgattcttg atcccgagct tcgggttgga agtgggtggg agagttcgag gccttgcgct      540

taaggagccc cttcgcctcg tgcttgagtt gaggcctggc ttgggcgctg gggccgccgc      600

gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt tcgataagtc tctagccatt      660

taaaattttt gatgacctgc tgcgacgctt tttttctggc aagatagtct tgtaaatgcg      720

ggccaagatc tgcacactgg tatttcggtt tttggggccg cgggcggcga cggggcccgt      780

gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag cgcggccacc gagaatcgga      840

cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg gcctcgcgcc gccgtgtatc      900

gccccgccct gggcggcaag gctggcccgg tcggcaccag ttgcgtgagc ggaaagatgg      960

ccgcttcccg gccctgctgc agggagctca aaatggagga cgcggcgctc gggagagcgg     1020

gcgggtgagt cacccacaca aaggaaaagg gcctttccgt cctcagccgt cgcttcatgt     1080

gactccacgg agtaccgggc gccgtccagg cacctcgatt agttctcgag cttttggagt     1140

acgtcgtctt taggttgggg ggaggggttt tatgcgatgg agtttcccca cactgagtgg     1200

gtggagactg aagttaggcc agcttggcac ttgatgtaat tctccttgga atttgccctt     1260

tttgagtttg gatcttggtt cattctcaag cctcagacag tggttcaaag tttttttctt     1320

ccatttcagg tgtcgtgag                                                  1339


<210>  558
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  558
ccggtaggcg ccaaccggct ccgttctttg gtggcccctt cgcgccacct tctactcctc       60

ccctagtcag gaagttcccc cccgccccgc agctcgcgtc gtgcaggacg tgacaaatgg      120

aagtagcacg tctcactagt ctcgtgcaga tggacagcac cgctgagcaa tggaagcggg      180

taggcctttg gggcagcggc caatagcagc tttgctcctt cgctttctgg gctcagaggc      240

tgggaagggg tgggtccggg ggcgggctca ggggcgggct caggggcggg gcgggcgccc      300

gaaggtcctc cggaggcccg gcattctgca cgcttcaaaa gcgcacgtct gccgcgctgt      360

tctcctcttc ctcatctccg ggcctttcga cctgcagcc                             399


<210>  559
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  559

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala 
            20          


<210>  560
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  560

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  561
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  561

Ser Ala Arg Asn Arg Gln Lys Arg Ser 
1               5                   


<210>  562
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  562

Ala Arg Asn Arg Gln Lys Arg Ser 
1               5               


<210>  563
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  563

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  564
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  564

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  565
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  565

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
545                 550                 555                 560 


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp 
                565                 570                 575     


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
            580                 585                 590         


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
        595                 600                 605             


Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
    610                 615                 620                 


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
625                 630                 635                 640 


Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
                645                 650     


<210>  566
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  566

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 540 


<210>  567
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  567
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggcc                                                                  66


<210>  568
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  568
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atcccctctg       60

gtggca                                                                  66


<210>  569
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  569
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc cagccctctg       60

gtggcc                                                                  66


<210>  570
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  570
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc aagccctctg       60

gtggca                                                                  66


<210>  571
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  571
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atccccactg       60

gtggca                                                                  66


<210>  572
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  572
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggcc                                                                  66


<210>  573
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  573
atgtgccacc agcagctggt catctcttgg ttcagcctgg tgtttctggc ctcccccctg       60

gtggcc                                                                  66


<210>  574
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  574
atgtgccacc agcagctggt catctcctgg ttctctctgg tgtttctggc atctcctctg       60

gtggca                                                                  66


<210>  575
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  575
atgtgccacc agcagctggt catctcttgg ttcagcctgg tgtttctggc atccccactg       60

gtggca                                                                  66


<210>  576
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  576

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  577
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  577
gcaaccaatt ttagtctact taaacaagca ggtgatgtag aagaaaatcc aggtcca          57


<210>  578
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  578

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Asn Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  579
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  579
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa caacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcaccgac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagt                                                    918


<210>  580
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  580
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagctaccca       60

tacgatgttc cagattacgc taactgggtg aacgtgatct ccgacctgaa aaagatcgag      120

gatttgatcc agagcatgca cattgacgcc accctgtata ccgagtccga cgtgcacccg      180

agttgcaagg tgactgccat gaagtgcttc ctgctggagc tgcaagtgat cagcctggag      240

agcggcgacg ccagcatcca cgacaccgtg gaaaacctta tcattctggc caacaatagc      300

ctgagcagca acggcaacgt gaccgaaagc ggatgtaagg aatgcgagga actggaagag      360

aagaatatca aagaattcct gcaaagcttc gtgcacatcg tgcagatgtt catcaacact      420

tctggatcct ga                                                          432


<210>  581
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  581
agcgccagga atcgccagaa gcggtcc                                           27


<210>  582
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  582
gcccggaata gacagaagag atct                                              24


<210>  583
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  583
atatgggaac tgaagaaaga tgtttatgtc gtagaattgg attggtatcc ggatgcccct       60

ggagaaatgg tggtcctcac ctgtgacacc cctgaagaag atggtatcac ctggaccttg      120

gaccagagca gtgaggtctt aggctctggc aaaaccctga ccatccaagt caaagagttt      180

ggagatgctg gccagtacac ctgtcacaaa ggaggcgagg ttctaagcca ttcgctcctg      240

ctgcttcaca aaaaggaaga tggaatttgg tccactgata ttttaaagga ccagaaagaa      300

cccaaaaata agacctttct aagatgcgag gccaagaatt attctggacg tttcacctgc      360

tggtggctga cgacaatcag tactgatttg acattcagtg tcaaaagcag cagaggctct      420

tctgaccccc aaggggtgac gtgcggagct gctacactct ctgcagagag agtcagaggg      480

gacaacaagg agtatgagta ctcagtggag tgccaggagg acagtgcctg cccagctgct      540

gaggagagtc tgcccattga ggtcatggtg gatgccgttc acaagctcaa gtatgaaaac      600

tacaccagca gcttcttcat cagggacatc atcaaacctg acccacccaa gaacttgcag      660

ctgaagccat taaagaattc tcggcaggtg gaggtcagct gggagtaccc tgacacctgg      720

agtactccac attcctactt ctccctgaca ttctgcgttc aggtccaggg caagagcaag      780

agagaaaaga aagatagagt cttcacggac aagacctcag ccacggtcat ctgccgcaaa      840

aatgccagca ttagcgtgcg ggcccaggac cgctactata gctcatcttg gagcgaatgg      900

gcatctgtgc cctgcagtta g                                                921


<210>  584
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  584
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagtcta gcgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatttgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtcctc taggggcagc      420

tccgaccccc agggcgtgac atgcggagca gccaccctgt ccgccgagag ggtgcgcggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tccagcagca      540

gaggagagcc tgcctatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacatcta gcttctttat ccgggacatc atcaagcccg atccacccaa gaacctgcag      660

ctgaagcctc tgaagaattc tagacaggtg gaggtgagct gggagtaccc agacacctgg      720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagagcaag      780

agggagaaga aggaccgcgt gttcaccgat aagacatccg ccaccgtgat ctgtaggaag      840

aacgcctcca tctctgtgag ggcccaggat cgctactatt cctctagctg gtccgagtgg      900

gcctctgtgc cctgtagc                                                    918


<210>  585
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  585
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca ccagaggagg atggcatcac ctggacactg      120

gatcagtcta gcgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatttgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtcctc taggggcagc      420

tccgaccccc agggcgtgac atgcggagca gccaccctgt ccgccgagag ggtgcgcggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tccagcagca      540

gaggagagcc tgcctatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacatcta gcttctttat ccgggacatc atcaagcccg atccacccaa gaacctgcag      660

ctgaagcctc tgaagaattc tagacaggtg gaggtgagct gggagtaccc agacacctgg      720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagtccaag      780

agggagaaga aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtaggaag      840

aacgcctcca tctctgtgag ggcccaggat cgctactatt cctctagctg gtccgagtgg      900

gcctctgtgc cctgtagc                                                    918


<210>  586
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  586
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagtcta gcgaggtgct gggctccggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatctgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gaggtgcgag gccaagaatt atagcggccg ctttacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtcctc taggggcagc      420

tccgaccccc agggcgtgac atgcggagca gccaccctgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tccagcagca      540

gaggagagcc tgcctatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacatcta gcttctttat cagggacatc atcaagcccg atccacccaa gaacctgcag      660

ctgaagcctc tgaagaattc tcgccaggtg gaggtgagct gggagtaccc agacacctgg      720

agcacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagtctaag      780

cgggagaaga aggacagagt gttcaccgat aagacaagcg ccaccgtgat ctgtcggaag      840

aacgcctcca tctctgtgcg ggcccaggat agatactatt cctctagctg gtccgagtgg      900

gcctctgtgc cctgtagc                                                    918


<210>  587
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  587
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagagct ccgaggtgct gggaagcggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatttgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gaggtgcgag gccaagaatt atagcggccg ctttacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtctag cagaggctcc      420

tctgaccccc agggcgtgac atgcggagca gccaccctgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag      660

ctgaagccac tgaagaattc tcgccaggtg gaggtgagct gggagtaccc agacacctgg      720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagagcaag      780

agggagaaga aggaccgcgt gttcaccgat aagacatccg ccaccgtgat ctgtcggaag      840

aacgcctcca tctctgtgcg ggcccaggat agatactatt ctagctcctg gtccgagtgg      900

gcctctgtgc cctgtagc                                                    918


<210>  588
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  588
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagagct ccgaggtgct gggaagcggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatttgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtctag ccggggctcc      420

tctgacccac agggagtgac atgcggagca gccaccctgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag      660

ctgaagccac tgaagaattc tcgccaggtg gaggtgagct gggagtaccc agacacctgg      720

tccacacccc actcttattt cagcctgacc ttttgcgtgc aggtgcaggg caagtccaag      780

cgggagaaga aggacagagt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag      840

aacgcctcca tctctgtgag ggcccaggat cgctactatt ctagctcctg gagcgagtgg      900

gcatccgtgc catgttct                                                    918


<210>  589
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  589
atctgggagc tcaagaaaga cgtgtacgtg gtggaactgg actggtaccc cgacgcccct       60

ggcgaaatgg tggtgctgac atgcgacacc cctgaggagg atggcattac ctggaccctc      120

gatcagagct ccgaggtgct gggcagcggc aaaaccctga ccatccaggt gaaggagttt      180

ggcgatgccg gccagtacac atgtcacaag ggcggcgagg tgctgagcca ctccctgctg      240

ctgctccaca agaaggaaga tggcatctgg agcaccgaca ttctgaagga tcagaaggag      300

cccaagaaca agacattcct gaggtgtgag gccaagaact acagcggcag gtttacctgc      360

tggtggctga caacaatcag caccgacctc acattctccg tcaagtcctc caggggttct      420

tccgaccctc aaggcgtgac atgcggcgct gccaccctga gcgctgagag agtcaggggc      480

gacaacaagg agtacgagta cagcgtcgaa tgtcaggagg acagcgcctg tcccgccgct      540

gaagagagcc tgcctatcga ggtgatggtg gacgccgtgc acaaactgaa gtatgagaat      600

tacacctcca gcttcttcat cagggacatc atcaaacccg atccccccaa gaacctgcag      660

ctgaagcctc tgaagaacag cagacaggtc gaagtgtcct gggagtaccc tgatacctgg      720

tccacacccc acagctactt cagcctgacc ttttgcgtgc aggtgcaggg caagagcaaa      780

agggagaaga aggacagggt gtttaccgac aagacctccg ccacagtgat ttgcagaaag      840

aacgcctcca tcagcgtgag ggcccaggac aggtattaca gcagctcctg gagcgaatgg      900

gctagcgtgc cctgtagc                                                    918


<210>  590
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  590
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cccgaggagg atggcatcac ctggacactg      120

gatcagtcta gcgaggtgct gggctccggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac ctgtcacaag ggcggcgagg tgctgtccca ctctctgctg      240

ctgctgcaca agaaggagga cggcatctgg tctacagaca tcctgaagga tcagaaggag      300

cctaagaaca agaccttcct gcggtgcgag gccaagaatt atagcggccg gttcacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtcctc tcggggcagc      420

tccgacccac agggagtgac atgcggagca gccaccctgt ccgccgagag ggtgcgcggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tccagcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacatcta gcttctttat ccgggacatc atcaagcccg atccccctaa gaacctgcag      660

ctgaagcctc tgaagaattc tagacaggtg gaggtgagct gggagtaccc cgacacctgg      720

agcacacctc acagctattt ctccctgacc ttttgcgtgc aggtgcaggg caagtccaag      780

agggagaaga aggaccgcgt gttcaccgat aagacatctg ccaccgtgat ctgtcggaag      840

aacgccagca tctccgtgag ggcccaggat cgctactatt cctctagctg gtctgagtgg      900

gccagcgtgc cctgttcc                                                    918


<210>  591
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  591
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca       60

ggcgagatgg tggtgctgac atgcgacacc cccgaggagg atggcatcac atggaccctg      120

gatcagtcct ctgaggtgct gggctccggc aagacactga ccatccaggt gaaggagttc      180

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg      240

ctgctgcaca agaaggagga cggcatctgg tccaccgaca tcctgaagga tcagaaggag      300

cccaagaaca agacattcct gagatgcgag gccaagaatt atagcggcag gtttacctgt      360

tggtggctga caaccatctc cacagatctg accttttctg tgaagagctc ccggggctct      420

agcgaccctc agggagtgac ctgcggagca gccacactgt ccgccgagcg ggtgagaggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacctcct ctttctttat cagagacatc atcaagccag atcctccaaa gaacctgcag      660

ctgaagcccc tgaagaatag caggcaggtg gaggtgtcct gggagtaccc agacacatgg      720

agcacccccc acagctattt ctccctgaca ttttgcgtgc aggtgcaggg caagtccaag      780

cgcgagaaga aggaccgggt gttcacagat aagacctctg ccacagtgat ctgtcgcaag      840

aacgcctcta tcagcgtgcg cgcccaggat cggtactata gctcctcttg gtctgagtgg      900

gccagcgtgc cttgttcc                                                    918


<210>  592
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  592
atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc cgatgcccct       60

ggcgagatgg tggtgctgac ctgcgacaca cctgaggagg atggcatcac ctggacactg      120

gatcagagct ccgaggtgct gggcagcggc aagaccctga caatccaggt gaaggagttc      180

ggcgacgccg gccagtacac atgtcacaag ggcggcgagg tgctgtctca cagcctgctg      240

ctgctgcaca agaaggagga cggcatctgg tccacagaca tcctgaagga tcagaaggag      300

ccaaagaaca agaccttcct gaggtgcgag gccaagaatt attctggcag gttcacctgt      360

tggtggctga ccacaatcag caccgatctg acattttccg tgaagtctag ccggggctcc      420

tctgaccccc agggagtgac atgcggagca gccaccctgt ccgccgagag ggtgagaggc      480

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca      540

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat      600

tatacaagct ccttctttat cagggacatc atcaagcctg atccccctaa gaacctgcag      660

ctgaagccac tgaagaattc tagacaggtg gaggtgagct gggagtaccc agacacctgg      720

agcacacccc actcctattt ctctctgacc ttttgcgtgc aggtgcaggg caagagcaag      780

agggagaaga aggacagagt gttcaccgat aagacatccg ccaccgtgat ctgtcggaag      840

aacgcctcca tctctgtgcg ggcccaggat cgctactatt ctagctcctg gagcgagtgg      900

gcatccgtgc catgttct                                                    918


<210>  593
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  593
agaaacctcc ccgtggccac tccagaccca ggaatgttcc catgccttca ccactcccaa       60

aacctgctga gggccgtcag caacatgctc cagaaggcca gacaaactct agaattttac      120

ccttgcactt ctgaagagat tgatcatgaa gatatcacaa aagataaaac cagcacagtg      180

gaggcctgtt taccattgga attaaccaag aatgagagtt gcctaaattc cagagagacc      240

tctttcataa ctaatgggag ttgcctggcc tccagaaaga cctcttttat gatggccctg      300

tgccttagta gtatttatga agacttgaag atgtaccagg tggagttcaa gaccatgaat      360

gcaaagcttc tgatggatcc taagaggcag atctttctag atcaaaacat gctggcagtt      420

attgatgagc tgatgcaggc cctgaatttc aacagtgaga ctgtgccaca aaaatcctcc      480

cttgaagaac cggattttta taaaactaaa atcaagctct gcatacttct tcatgctttc      540

agaattcggg cagtgactat tgatagagtg atgagctatc tgaatgcttc ctaa            594


<210>  594
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  594
cgcaatctgc cagtggccac ccctgaccca ggcatgttcc cctgcctgca ccacagccag       60

aacctgctga gggccgtgtc caatatgctg cagaaggccc gccagacact ggagttttac      120

ccttgtacct ctgaggagat cgaccacgag gatatcacaa aggataagac cagcacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagtcct gtctgaacag ccgggaaacc      240

agcttcatca ccaacggctc ctgcctggcc tctcgcaaga ccagcttcat gatggccctg      300

tgcctgtcct ctatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagcggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aatagcgaga cagtgccaca gaagagctcc      480

ctggaggagc ccgatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttt      540

cggatcagag ccgtgaccat cgacagagtg atgtcctatc tgaatgcctc ttga            594


<210>  595
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  595
cgcaatctgc cagtggccac ccctgaccca ggcatgttcc cctgcctgca ccacagccag       60

aacctgctga gggccgtgtc caatatgctg cagaaggccc gccagacact ggagttttac      120

ccttgtacca gcgaggagat cgaccacgag gatatcacaa aggataagac ctccacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagtcct gtctgaacag ccgggaaacc      240

agcttcatca ccaacggctc ctgcctggcc tctcgcaaga ccagcttcat gatggccctg      300

tgcctgtcct ctatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagcggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aatagcgaga cagtgccaca gaagagctcc      480

ctggaggagc ccgatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttt      540

cggatcagag ccgtgaccat cgacagagtg atgtcctatc tgaatgcctc ttga            594


<210>  596
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  596
agaaatctgc cagtggccac ccctgaccca ggcatgttcc cctgcctgca ccactctcag       60

aacctgctgc gggccgtgag caatatgctg cagaaggcca gacagacact ggagttttac      120

ccttgtacct ccgaggagat cgaccacgag gatatcacaa aggataagac ctctacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagtcct gtctgaacag ccgggaaacc      240

agcttcatca ccaacggctc ctgcctggcc tctagaaaga ccagcttcat gatggccctg      300

tgcctgtcct ctatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagaggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aatagcgaga cagtgccaca gaagagctcc      480

ctggaggagc ccgatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttt      540

aggatccgcg ccgtgaccat cgaccgcgtg atgtcctatc tgaatgcctc ttga            594


<210>  597
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  597
agaaatctgc cagtggcaac ccctgaccca ggaatgttcc cttgcctgca ccacagccag       60

aacctgctgc gggccgtgtc caatatgctg cagaaggcca gacagacact ggagttttac      120

ccttgtacct ctgaggagat cgaccacgag gatatcacaa aggataagac cagcacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagtcct gtctgaacag ccgggaaacc      240

agcttcatca ccaacggctc ctgcctggcc tctcgcaaga ccagcttcat gatggccctg      300

tgcctgtcta gcatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagaggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aatagcgaga cagtgccaca gaagtcctct      480

ctggaggagc ccgatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttt      540

aggatccgcg ccgtgaccat cgacagagtg atgtcctatc tgaacgcctc t               591


<210>  598
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  598
agaaatctgc cagtggcaac ccctgaccca ggaatgttcc cttgcctgca ccacagccag       60

aacctgctga gggccgtgtc caatatgctg cagaaggccc gccagacact ggagttttac      120

ccttgtacca gcgaggagat cgaccacgag gatatcacaa aggataagac ctccacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagagct gtctgaattc ccgggagaca      240

tctttcatca ccaacggcag ctgcctggcc tccagaaaga catcttttat gatggccctg      300

tgcctgtcta gcatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagaggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aatagcgaga cagtgccaca gaagtcctct      480

ctggaggagc ccgatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttt      540

aggatccgcg ccgtgaccat cgaccgcgtg atgtcttatc tgaacgcatc c               591


<210>  599
<211>  594
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  599
agaaacctgc ctgtcgctac ccccgacccc ggaatgttcc cctgcctgca ccactcccag       60

aacctcctga gggccgtgtc caacatgctg cagaaggcta gacagaccct cgaattctac      120

ccctgtacca gcgaggagat cgaccatgag gacatcacca aggataagac cagcaccgtg      180

gaggcttgcc tgcctctgga gctgaccaaa aacgagagct gcctgaacag cagggaaacc      240

agcttcatta ccaacggctc ctgcctggcc tccaggaaga catccttcat gatggccctg      300

tgcctcagca gcatctacga ggacctgaag atgtatcagg tggagtttaa gaccatgaat      360

gccaagctgc tgatggaccc taagaggcag atcttcctgg accagaatat gctggccgtg      420

attgacgagc tgatgcaggc cctcaacttt aacagcgaga ccgtgcccca gaaaagcagc      480

ctcgaagagc ctgacttcta caaaaccaag attaagctgt gtatcctgct gcacgccttc      540

aggatcaggg ccgtgaccat cgacagggtg atgagctacc tgaacgccag ctaa            594


<210>  600
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  600
agaaatctgc cagtggccac ccctgaccca ggcatgttcc cctgcctgca ccacagccag       60

aacctgctga gggccgtgtc caatatgctg cagaaggccc gccagacact ggagttttac      120

ccctgtacca gcgaggagat cgaccacgag gatatcacaa aggataagac ctccacagtg      180

gaggcctgcc tgcctctgga gctgaccaag aacgagtctt gtctgaatag cagggagaca      240

tccttcatca ccaacggctc ttgcctggcc agccgcaaga catcctttat gatggccctg      300

tgcctgtcct ctatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagaggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aattccgaga cagtgcctca gaagagctcc      480

ctggaggagc cagatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttt      540

cggatcagag ccgtgaccat cgaccgcgtg atgtcttatc tgaatgccag cggatcc         597


<210>  601
<211>  597
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  601
cggaatctgc ctgtggcaac ccccgaccct ggaatgttcc catgcctgca ccacagccag       60

aacctgctgc gcgccgtgtc caatatgctg cagaaggccc ggcagaccct ggagttttac      120

ccatgtacaa gcgaggagat cgaccacgag gatatcacca aggataagac atccaccgtg      180

gaggcatgcc tgccactgga gctgacaaag aacgagtctt gtctgaacag ccgggagaca      240

agcttcatca caaacggctc ttgcctggcc agccggaaga cctcctttat gatggccctg      300

tgcctgagct ccatctacga ggacctgaag atgtatcagg tggagttcaa gacaatgaac      360

gccaagctgc tgatggaccc caagcgccag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttt aatagcgaga cagtgcccca gaagtctagc      480

ctggaggagc ctgatttcta caagacaaag atcaagctgt gcatcctgct gcacgccttc      540

cggatcagag ccgtgaccat cgacagagtg atgtcttatc tgaatgccag cggatcc         597


<210>  602
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  602
cgcaatctgc cagtggcaac ccctgaccca ggaatgttcc cttgcctgca ccacagccag       60

aacctgctgc gggccgtgtc caatatgctg cagaaggccc gccagacact ggagttttac      120

ccttgtacct ctgaggagat cgaccacgag gatatcacaa aggataagac cagcacagtg      180

gaggcctgcc tgccactgga gctgaccaag aacgagagct gtctgaattc cagggagaca      240

tctttcatca ccaacggcag ctgcctggcc tccagaaaga catcttttat gatggccctg      300

tgcctgtcta gcatctacga ggacctgaag atgtatcagg tggagttcaa gaccatgaac      360

gccaagctgc tgatggaccc taagaggcag atctttctgg atcagaatat gctggccgtg      420

atcgacgagc tgatgcaggc cctgaacttc aattccgaga cagtgccaca gaagtcctct      480

ctggaggagc ccgatttcta caagaccaag atcaagctgt gcatcctgct gcacgccttc      540

aggatcaggg ccgtgaccat cgacagagtg atgagctatc tgaacgccag c               591


<210>  603
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  603
atctctctga ttgcggcgct ggcagttgac tacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgttatcgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta cgaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgttga         477


<210>  604
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  604
gtgggcagcc tgaactgtat cgtggccgtg tcccagaaca tgggcatcgg caagaatggc       60

gatctgccat ggccccctct gcggaacgag ttcagatact tctttaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacctg gttttctatc      180

cccgagaaga acagacctct gaagggcagg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgaca      300

gagcagccag agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagt ttatgaatca ccccggccac ctgaagctgt tcgtgaccag aatcatgcag      420

gactttgagt ccgatacatt ctttcctgag atcgatctgg agaagtacaa gctgctgcca      480

gagtatcccg gcgtgctgtc tgacgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaacgat                                                    558


<210>  605
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  605
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atcccctctg       60

gtggcaggag tgcaggtgga gacaatctct cctggcgatg gccggacctt cccaaagaga      120

ggccagacat gcgtggtgca ctacaccggc atgctggagg acggcaagaa ggtggacagc      180

tcccgggata gaaacaagcc attcaagttt atgctgggca agcaggaagt gatcagggga      240

tgggaggagg gagtggcaca gatgtctgtg ggccagagag ccaagctgac aatcagccct      300

gattacgcat atggagcaac cggacaccca ggaatcatcc cacctcacgc caccctggtg      360

tttgatgtgg agctgctgaa gccagaggga ggatccggag gcatctggga gctgaagaag      420

gacgtgtacg tggtggagct ggactggtat cccgatgccc ctggcgagat ggtggtgctg      480

acctgcgaca cacctgagga ggatggcatc acctggacac tggatcagtc tagcgaggtg      540

ctgggcagcg gcaagaccct gacaatccag gtgaaggagt tcggcgacgc cggccagtac      600

acatgtcaca agggcggcga ggtgctgtct cacagcctgc tgctgctgca caagaaggag      660

gacggcattt ggtccacaga catcctgaag gatcagaagg agccaaagaa caagaccttc      720

ctgcggtgcg aggccaagaa ttatagcggc cggttcacct gttggtggct gaccacaatc      780

agcaccgatc tgacattttc cgtgaagtcc tctaggggca gctccgaccc ccagggcgtg      840

acatgcggag cagccaccct gtccgccgag agggtgcgcg gcgataacaa ggagtacgag      900

tattccgtgg agtgccagga ggactctgcc tgtccagcag cagaggagag cctgcctatc      960

gaagtgatgg tggatgccgt gcacaagctg aagtacgaga attatacatc tagcttcttt     1020

atccgggaca tcatcaagcc cgatccaccc aagaacctgc agctgaagcc tctgaagaat     1080

tctagacagg tggaggtgag ctgggagtac ccagacacct ggtccacacc ccactcttat     1140

ttcagcctga ccttttgcgt gcaggtgcag ggcaagagca agagggagaa gaaggaccgc     1200

gtgttcaccg ataagacatc cgccaccgtg atctgtagga agaacgcctc catctctgtg     1260

agggcccagg atcgctacta ttcctctagc tggtccgagt gggcctctgt gccctgtagc     1320

ggaggaggag gatccggagg aggaggatct ggcggcggcg gcagccgcaa tctgccagtg     1380

gccacccctg acccaggcat gttcccctgc ctgcaccaca gccagaacct gctgagggcc     1440

gtgtccaata tgctgcagaa ggcccgccag acactggagt tttacccttg tacctctgag     1500

gagatcgacc acgaggatat cacaaaggat aagaccagca cagtggaggc ctgcctgcca     1560

ctggagctga ccaagaacga gtcctgtctg aacagccggg aaaccagctt catcaccaac     1620

ggctcctgcc tggcctctcg caagaccagc ttcatgatgg ccctgtgcct gtcctctatc     1680

tacgaggacc tgaagatgta tcaggtggag ttcaagacca tgaacgccaa gctgctgatg     1740

gaccctaagc ggcagatctt tctggatcag aatatgctgg ccgtgatcga cgagctgatg     1800

caggccctga acttcaatag cgagacagtg ccacagaaga gctccctgga ggagcccgat     1860

ttctacaaga ccaagatcaa gctgtgcatc ctgctgcacg cctttcggat cagagccgtg     1920

accatcgaca gagtgatgtc ctatctgaat gcctcttga                            1959


<210>  606
<211>  1962
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  606
atgggcgtgc aggtggagac aatctcccct ggcgatggcc ggaccttccc aaagagaggc       60

cagacatgcg tggtgcacta caccggcatg ctggaggacg gcaagaaggt ggacagctcc      120

cgggatagaa acaagccttt caagtttatg ctgggcaagc aggaagtgat caggggatgg      180

gaggagggag tggcacagat gtctgtgggc cagagagcca agctgacaat cagccctgat      240

tacgcatatg gagcaaccgg acacccagga atcatcccac ctcacgccac cctggtgttt      300

gacgtggagc tgctgaagcc agagggagga tctggaggaa tgtgccacca gcagctggtc      360

atcagctggt tctccctggt gtttctggcc agccctctgg tggccatctg ggagctgaag      420

aaggacgtgt acgtggtgga gctggactgg tatcccgatg cccctggcga gatggtggtg      480

ctgacctgcg acacaccaga ggaggatggc atcacctgga cactggatca gtctagcgag      540

gtgctgggca gcggcaagac cctgacaatc caggtgaagg agttcggcga cgccggccag      600

tacacatgtc acaagggcgg cgaggtgctg tctcacagcc tgctgctgct gcacaagaag      660

gaggacggca tttggtccac agacatcctg aaggatcaga aggagccaaa gaacaagacc      720

ttcctgcggt gcgaggccaa gaattatagc ggccggttca cctgttggtg gctgaccaca      780

atcagcaccg atctgacatt ttccgtgaag tcctctaggg gcagctccga cccccagggc      840

gtgacatgcg gagcagccac cctgtccgcc gagagggtgc gcggcgataa caaggagtac      900

gagtattccg tggagtgcca ggaggactct gcctgtccag cagcagagga gagcctgcct      960

atcgaagtga tggtggatgc cgtgcacaag ctgaagtacg agaattatac atctagcttc     1020

tttatccggg acatcatcaa gcccgatcca cccaagaacc tgcagctgaa gcctctgaag     1080

aattctagac aggtggaggt gagctgggag tacccagaca cctggtccac accccactct     1140

tatttcagcc tgaccttttg cgtgcaggtg cagggcaagt ccaagaggga gaagaaggac     1200

cgcgtgttca ccgataagac atctgccacc gtgatctgta ggaagaacgc ctccatctct     1260

gtgagggccc aggatcgcta ctattcctct agctggtccg agtgggcctc tgtgccctgt     1320

agcggaggag gaggatccgg aggaggagga tctggcggcg gcggcagccg caatctgcca     1380

gtggccaccc ctgacccagg catgttcccc tgcctgcacc acagccagaa cctgctgagg     1440

gccgtgtcca atatgctgca gaaggcccgc cagacactgg agttttaccc ttgtaccagc     1500

gaggagatcg accacgagga tatcacaaag gataagacct ccacagtgga ggcctgcctg     1560

ccactggagc tgaccaagaa cgagtcctgt ctgaacagcc gggaaaccag cttcatcacc     1620

aacggctcct gcctggcctc tcgcaagacc agcttcatga tggccctgtg cctgtcctct     1680

atctacgagg acctgaagat gtatcaggtg gagttcaaga ccatgaacgc caagctgctg     1740

atggacccta agcggcagat ctttctggat cagaatatgc tggccgtgat cgacgagctg     1800

atgcaggccc tgaacttcaa tagcgagaca gtgccacaga agagctccct ggaggagccc     1860

gatttctaca agaccaagat caagctgtgc atcctgctgc acgcctttcg gatcagagcc     1920

gtgaccatcg acagagtgat gtcctatctg aatgcctctt ga                        1962


<210>  607
<211>  1971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  607
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc aagccctctg       60

gtggcaggag tgcaggtgga gacaatctcc cctggcgatg gcaggacctt cccaaagcgc      120

ggccagacat gcgtggtgca ctacaccggc atgctggagg acggcaagaa ggtggacagc      180

tcccgggata gaaacaagcc attcaagttt atgctgggca agcaggaagt gatcagggga      240

tgggaggagg gagtggcaca gatgtccgtg ggacagcgcg ccaagctgac aatctctcct      300

gattacgcat atggagcaac cggacaccca ggaatcatcc cacctcacgc caccctggtg      360

tttgacgtgg agctgctgaa gcccgagagc gccaggaatc gccagaagcg gtccatctgg      420

gagctgaaga aggacgtgta cgtggtggag ctggactggt atcccgatgc ccctggcgag      480

atggtggtgc tgacctgcga cacacctgag gaggatggca tcacctggac actggatcag      540

tctagcgagg tgctgggctc cggcaagacc ctgacaatcc aggtgaagga gttcggcgac      600

gccggccagt acacatgtca caagggcggc gaggtgctgt ctcacagcct gctgctgctg      660

cacaagaagg aggacggcat ctggtccaca gacatcctga aggatcagaa ggagccaaag      720

aacaagacct tcctgaggtg cgaggccaag aattatagcg gccgctttac ctgttggtgg      780

ctgaccacaa tcagcaccga tctgacattt tccgtgaagt cctctagggg cagctccgac      840

ccccagggcg tgacatgcgg agcagccacc ctgtccgccg agcgggtgag aggcgataac      900

aaggagtacg agtattccgt ggagtgccag gaggactctg cctgtccagc agcagaggag      960

agcctgccta tcgaagtgat ggtggatgcc gtgcacaagc tgaagtacga gaattataca     1020

tctagcttct ttatcaggga catcatcaag cccgatccac ccaagaacct gcagctgaag     1080

cctctgaaga attctcgcca ggtggaggtg agctgggagt acccagacac ctggagcaca     1140

ccccactctt atttcagcct gaccttttgc gtgcaggtgc agggcaagtc taagcgggag     1200

aagaaggaca gagtgttcac cgataagaca agcgccaccg tgatctgtcg gaagaacgcc     1260

tccatctctg tgcgggccca ggatagatac tattcctcta gctggtccga gtgggcctct     1320

gtgccctgta gcggaggagg aggatccgga ggaggaggat ctggcggcgg cggcagcaga     1380

aatctgccag tggccacccc tgacccaggc atgttcccct gcctgcacca ctctcagaac     1440

ctgctgcggg ccgtgagcaa tatgctgcag aaggccagac agacactgga gttttaccct     1500

tgtacctccg aggagatcga ccacgaggat atcacaaagg ataagacctc tacagtggag     1560

gcctgcctgc cactggagct gaccaagaac gagtcctgtc tgaacagccg ggaaaccagc     1620

ttcatcacca acggctcctg cctggcctct agaaagacca gcttcatgat ggccctgtgc     1680

ctgtcctcta tctacgagga cctgaagatg tatcaggtgg agttcaagac catgaacgcc     1740

aagctgctga tggaccctaa gaggcagatc tttctggatc agaatatgct ggccgtgatc     1800

gacgagctga tgcaggccct gaacttcaat agcgagacag tgccacagaa gagctccctg     1860

gaggagcccg atttctacaa gaccaagatc aagctgtgca tcctgctgca cgcctttagg     1920

atccgcgccg tgaccatcga ccgcgtgatg tcctatctga atgcctcttg a              1971


<210>  608
<211>  1968
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  608
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atccccactg       60

gtggcaatct gggagctgaa gaaggacgtg tacgtggtgg agctggactg gtatcccgat      120

gcccctggcg agatggtggt gctgacctgc gacacacctg aggaggatgg catcacctgg      180

acactggatc agagctccga ggtgctggga agcggcaaga ccctgacaat ccaggtgaag      240

gagttcggcg acgccggcca gtacacatgt cacaagggcg gcgaggtgct gtctcacagc      300

ctgctgctgc tgcacaagaa ggaggacggc atttggtcca cagacatcct gaaggatcag      360

aaggagccaa agaacaagac cttcctgagg tgcgaggcca agaattatag cggccgcttt      420

acctgttggt ggctgaccac aatcagcacc gatctgacat tttccgtgaa gtctagcaga      480

ggctcctctg acccccaggg cgtgacatgc ggagcagcca ccctgtccgc cgagcgggtg      540

agaggcgata acaaggagta cgagtattcc gtggagtgcc aggaggactc tgcctgtcct      600

gcagcagagg agagcctgcc aatcgaagtg atggtggatg ccgtgcacaa gctgaagtac      660

gagaattata caagctcctt ctttatcagg gacatcatca agcctgatcc ccctaagaac      720

ctgcagctga agccactgaa gaattctcgc caggtggagg tgagctggga gtacccagac      780

acctggtcca caccccactc ttatttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaagaggg agaagaagga ccgcgtgttc accgataaga catccgccac cgtgatctgt      900

cggaagaacg cctccatctc tgtgcgggcc caggatagat actattctag ctcctggtcc      960

gagtgggcct ctgtgccctg tagcggagga ggaggatccg gaggaggagg atctggcgga     1020

ggaggcagca gaaatctgcc agtggcaacc cctgacccag gaatgttccc ttgcctgcac     1080

cacagccaga acctgctgcg ggccgtgtcc aatatgctgc agaaggccag acagacactg     1140

gagttttacc cttgtacctc tgaggagatc gaccacgagg atatcacaaa ggataagacc     1200

agcacagtgg aggcctgcct gccactggag ctgaccaaga acgagtcctg tctgaacagc     1260

cgggaaacca gcttcatcac caacggctcc tgcctggcct ctcgcaagac cagcttcatg     1320

atggccctgt gcctgtctag catctacgag gacctgaaga tgtatcaggt ggagttcaag     1380

accatgaacg ccaagctgct gatggaccct aagaggcaga tctttctgga tcagaatatg     1440

ctggccgtga tcgacgagct gatgcaggcc ctgaacttca atagcgagac agtgccacag     1500

aagtcctctc tggaggagcc cgatttctac aagaccaaga tcaagctgtg catcctgctg     1560

cacgccttta ggatccgcgc cgtgaccatc gacagagtga tgtcctatct gaacgcctct     1620

gcccggaata gacagaagag atctggcgtg caggtggaga caatcagccc cggcgatggc     1680

cggacctttc ctaagagagg ccagacatgc gtggtgcact acaccggcat gctgggcgac     1740

ggcaagaagg tggacagctc cagggatcgc aataagccct tcaagtttat gctgggcaag     1800

caggaagtga tcaggggatg ggaggaggga gtggcacaga tgtccgtggg acagggcgcc     1860

aagctgacaa tctctccaga ttacgcatat ggagcaaccg gacacccagg aatcatccca     1920

ccccacgcca ccctggtgtt cgacgtggag ctgctggagc tggagtga                  1968


<210>  609
<211>  1956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  609
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atccccactg       60

gtggcaatct gggagctgaa gaaggacgtg tacgtggtgg agctggactg gtatcccgat      120

gcccctggcg agatggtggt gctgacctgc gacacacctg aggaggatgg catcacctgg      180

acactggatc agagctccga ggtgctggga agcggcaaga ccctgacaat ccaggtgaag      240

gagttcggcg acgccggcca gtacacatgt cacaagggcg gcgaggtgct gtctcacagc      300

ctgctgctgc tgcacaagaa ggaggacggc atttggtcca cagacatcct gaaggatcag      360

aaggagccaa agaacaagac cttcctgcgg tgcgaggcca agaattatag cggccggttc      420

acctgttggt ggctgaccac aatcagcacc gatctgacat tttccgtgaa gtctagccgg      480

ggctcctctg acccacaggg agtgacatgc ggagcagcca ccctgtccgc cgagcgggtg      540

agaggcgata acaaggagta cgagtattcc gtggagtgcc aggaggactc tgcctgtcct      600

gcagcagagg agagcctgcc aatcgaagtg atggtggatg ccgtgcacaa gctgaagtac      660

gagaattata caagctcctt ctttatcagg gacatcatca agcctgatcc ccctaagaac      720

ctgcagctga agccactgaa gaattctcgc caggtggagg tgagctggga gtacccagac      780

acctggtcca caccccactc ttatttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

tccaagcggg agaagaagga cagagtgttc accgataaga catctgccac cgtgatctgt      900

cggaagaacg cctccatctc tgtgagggcc caggatcgct actattctag ctcctggagc      960

gagtgggcat ccgtgccatg ttctggagga ggaggaagcg gaggaggagg atccggcgga     1020

ggaggctcta gaaatctgcc agtggcaacc cctgacccag gaatgttccc ttgcctgcac     1080

cacagccaga acctgctgag ggccgtgtcc aatatgctgc agaaggcccg ccagacactg     1140

gagttttacc cttgtaccag cgaggagatc gaccacgagg atatcacaaa ggataagacc     1200

tccacagtgg aggcctgcct gccactggag ctgaccaaga acgagagctg tctgaattcc     1260

cgggagacat ctttcatcac caacggcagc tgcctggcct ccagaaagac atcttttatg     1320

atggccctgt gcctgtctag catctacgag gacctgaaga tgtatcaggt ggagttcaag     1380

accatgaacg ccaagctgct gatggaccct aagaggcaga tctttctgga tcagaatatg     1440

ctggccgtga tcgacgagct gatgcaggcc ctgaacttca atagcgagac agtgccacag     1500

aagtcctctc tggaggagcc cgatttctac aagaccaaga tcaagctgtg catcctgctg     1560

cacgccttta ggatccgcgc cgtgaccatc gaccgcgtga tgtcttatct gaacgcatcc     1620

ggaggatctg gaggagtgca ggtggagaca atcagccccg gcgatggcag gacctttcct     1680

aagcgcggcc agacatgcgt ggtgcactac accggcatgc tgggcgacgg caagaaggtg     1740

gacagctccc gggatagaaa taagcccttc aagtttatgc tgggcaagca ggaagtgatc     1800

agaggctggg aggagggagt ggcacagatg tctgtgggac agggcgccaa gctgacaatc     1860

agcccagatt acgcatatgg agcaaccgga cacccaggaa tcatcccacc ccacgccacc     1920

ctggtgttcg acgtggagct gctggagctg gagtga                               1956


<210>  610
<211>  1623
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  610
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

taa                                                                   1623


<210>  611
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  611
atgtgccacc agcagctggt catctcttgg ttcagcctgg tgtttctggc ctcccccctg       60

gtggccatct ctctgatcgc cgccctggcc gtggattacg tgatcggcat ggagaacgcc      120

atgccatgga atctgccagc agacctggca tggttcaaga ggaacacact gaataagcca      180

gtgatcatgg gcagacacac ctgggagtcc atcggccggc cactgccagg cagaaagaac      240

atcatcctga gctcccagcc cggcacagac gatagggtga cctgggtgaa gagcgtggac      300

gaggcaatcg cagcatgcgg cgatgtgcct gagatcatgg tcatcggagg aggacgcgtg      360

atcgagcagt tcctgccaaa ggcccagaag ctgtacctga cacacatcga tgccgaggtg      420

gagggcgaca cccactttcc tgattatgag ccagacgatt gggagtccgt gttctctgag      480

tttcacgacg ccgatgccca gaactctcac agctattgtt ttgagatcct ggagcggaga      540

gagtctaggc gcgtgcggag aaataagcgg agcaagatct gggagctgaa gaaggacgtg      600

tacgtggtgg agctggactg gtatcccgat gcccctggcg agatggtggt gctgacctgc      660

gacacacccg aggaggatgg catcacctgg acactggatc agtctagcga ggtgctgggc      720

tccggcaaga ccctgacaat ccaggtgaag gagttcggcg acgccggcca gtacacctgt      780

cacaagggcg gcgaggtgct gtcccactct ctgctgctgc tgcacaagaa ggaggacggc      840

atctggtcta cagacatcct gaaggatcag aaggagccta agaacaagac cttcctgcgg      900

tgcgaggcca agaattatag cggccggttc acctgttggt ggctgaccac aatcagcacc      960

gatctgacat tttccgtgaa gtcctctcgg ggcagctccg acccacaggg agtgacatgc     1020

ggagcagcca ccctgtccgc cgagagggtg cgcggcgata acaaggagta cgagtattcc     1080

gtggagtgcc aggaggactc tgcctgtcca gcagcagagg agagcctgcc aatcgaagtg     1140

atggtggatg ccgtgcacaa gctgaagtac gagaattata catctagctt ctttatccgg     1200

gacatcatca agcccgatcc ccctaagaac ctgcagctga agcctctgaa gaattctaga     1260

caggtggagg tgagctggga gtaccccgac acctggagca cacctcacag ctatttctcc     1320

ctgacctttt gcgtgcaggt gcagggcaag tccaagaggg agaagaagga ccgcgtgttc     1380

accgataaga catctgccac cgtgatctgt cggaagaacg ccagcatctc cgtgagggcc     1440

caggatcgct actattcctc tagctggtct gagtgggcca gcgtgccctg ttccggcggc     1500

ggcggctctg gaggaggagg cagcggcgga ggaggctcca gaaatctgcc agtggccacc     1560

cctgacccag gcatgttccc ctgcctgcac cacagccaga acctgctgag ggccgtgtcc     1620

aatatgctgc agaaggcccg ccagacactg gagttttacc cctgtaccag cgaggagatc     1680

gaccacgagg atatcacaaa ggataagacc tccacagtgg aggcctgcct gcctctggag     1740

ctgaccaaga acgagtcttg tctgaatagc agggagacat ccttcatcac caacggctct     1800

tgcctggcca gccgcaagac atcctttatg atggccctgt gcctgtcctc tatctacgag     1860

gacctgaaga tgtatcaggt ggagttcaag accatgaacg ccaagctgct gatggaccct     1920

aagaggcaga tctttctgga tcagaatatg ctggccgtga tcgacgagct gatgcaggcc     1980

ctgaacttca attccgagac agtgcctcag aagagctccc tggaggagcc agatttctac     2040

aagaccaaga tcaagctgtg catcctgctg cacgcctttc ggatcagagc cgtgaccatc     2100

gaccgcgtga tgtcttatct gaatgccagc                                      2130


<210>  612
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  612
atgtgccacc agcagctggt catctcctgg ttctctctgg tgtttctggc atctcctctg       60

gtggcagtgg gcagcctgaa ctgtatcgtg gccgtgtccc agaacatggg catcggcaag      120

aatggcgatc tgccatggcc ccctctgcgg aacgagttca gatacttctt taggatgacc      180

acaaccagct ccgtggaggg caagcagaac ctggtcatca tgggcaagaa gacctggttt      240

tctatccccg agaagaacag acctctgaag ggcaggatca atctggtgct gagcagagag      300

ctgaaggagc caccacaggg agcacacttc ctgagccgga gcctggacga tgccctgaag      360

ctgacagagc agccagagct ggccaacaag gtggacatgg tgtggatcgt gggcggctct      420

agcgtgatca aggagtttat gaatcacccc ggccacctga agctgttcgt gaccagaatc      480

atgcaggact ttgagtccga tacattcttt cctgagatcg atctggagaa gtacaagctg      540

ctgccagagt atcccggcgt gctgtctgac gtgcaggagg agaagggcat caagtacaag      600

ttcgaggtgt atgagaagaa cgatgagtct cggagagtga ggcgcaataa gaggagcaag      660

atctgggagc tgaagaagga cgtgtacgtg gtggagctgg actggtatcc tgatgcccca      720

ggcgagatgg tggtgctgac atgcgacacc cccgaggagg atggcatcac atggaccctg      780

gatcagtcct ctgaggtgct gggctccggc aagacactga ccatccaggt gaaggagttc      840

ggcgacgccg gccagtacac ctgtcacaag ggaggagagg tgctgagcca ctccctgctg      900

ctgctgcaca agaaggagga cggcatctgg tccaccgaca tcctgaagga tcagaaggag      960

cccaagaaca agacattcct gagatgcgag gccaagaatt atagcggcag gtttacctgt     1020

tggtggctga caaccatctc cacagatctg accttttctg tgaagagctc ccggggctct     1080

agcgaccctc agggagtgac ctgcggagca gccacactgt ccgccgagcg ggtgagaggc     1140

gataacaagg agtacgagta ttccgtggag tgccaggagg actctgcctg tcctgcagca     1200

gaggagagcc tgccaatcga agtgatggtg gatgccgtgc acaagctgaa gtacgagaat     1260

tatacctcct ctttctttat cagagacatc atcaagccag atcctccaaa gaacctgcag     1320

ctgaagcccc tgaagaatag caggcaggtg gaggtgtcct gggagtaccc agacacatgg     1380

agcacccccc acagctattt ctccctgaca ttttgcgtgc aggtgcaggg caagtccaag     1440

cgcgagaaga aggaccgggt gttcacagat aagacctctg ccacagtgat ctgtcgcaag     1500

aacgcctcta tcagcgtgcg cgcccaggat cggtactata gctcctcttg gtctgagtgg     1560

gccagcgtgc cttgttccgg cggcggcggc tctggaggag gaggcagcgg cggaggaggc     1620

tcccggaatc tgcctgtggc aacccccgac cctggaatgt tcccatgcct gcaccacagc     1680

cagaacctgc tgcgcgccgt gtccaatatg ctgcagaagg cccggcagac cctggagttt     1740

tacccatgta caagcgagga gatcgaccac gaggatatca ccaaggataa gacatccacc     1800

gtggaggcat gcctgccact ggagctgaca aagaacgagt cttgtctgaa cagccgggag     1860

acaagcttca tcacaaacgg ctcttgcctg gccagccgga agacctcctt tatgatggcc     1920

ctgtgcctga gctccatcta cgaggacctg aagatgtatc aggtggagtt caagacaatg     1980

aacgccaagc tgctgatgga ccccaagcgc cagatctttc tggatcagaa tatgctggcc     2040

gtgatcgacg agctgatgca ggccctgaac tttaatagcg agacagtgcc ccagaagtct     2100

agcctggagg agcctgattt ctacaagaca aagatcaagc tgtgcatcct gctgcacgcc     2160

ttccggatca gagccgtgac catcgacaga gtgatgtctt atctgaatgc cagc           2214


<210>  613
<211>  1980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  613
atgtgccacc agcagctggt catctcttgg ttcagcctgg tgtttctggc atccccactg       60

gtggcaatct gggagctgaa gaaggacgtg tacgtggtgg agctggactg gtatcccgat      120

gcccctggcg agatggtggt gctgacctgc gacacacctg aggaggatgg catcacctgg      180

acactggatc agagctccga ggtgctgggc agcggcaaga ccctgacaat ccaggtgaag      240

gagttcggcg acgccggcca gtacacatgt cacaagggcg gcgaggtgct gtctcacagc      300

ctgctgctgc tgcacaagaa ggaggacggc atctggtcca cagacatcct gaaggatcag      360

aaggagccaa agaacaagac cttcctgagg tgcgaggcca agaattattc tggcaggttc      420

acctgttggt ggctgaccac aatcagcacc gatctgacat tttccgtgaa gtctagccgg      480

ggctcctctg acccccaggg agtgacatgc ggagcagcca ccctgtccgc cgagagggtg      540

agaggcgata acaaggagta cgagtattcc gtggagtgcc aggaggactc tgcctgtcct      600

gcagcagagg agagcctgcc aatcgaagtg atggtggatg ccgtgcacaa gctgaagtac      660

gagaattata caagctcctt ctttatcagg gacatcatca agcctgatcc ccctaagaac      720

ctgcagctga agccactgaa gaattctaga caggtggagg tgagctggga gtacccagac      780

acctggagca caccccactc ctatttctct ctgacctttt gcgtgcaggt gcagggcaag      840

agcaagaggg agaagaagga cagagtgttc accgataaga catccgccac cgtgatctgt      900

cggaagaacg cctccatctc tgtgcgggcc caggatcgct actattctag ctcctggagc      960

gagtgggcat ccgtgccatg ttctggagga ggaggcagcg gcggaggagg ctccggcggc     1020

ggcggctctc gcaatctgcc agtggcaacc cctgacccag gaatgttccc ttgcctgcac     1080

cacagccaga acctgctgcg ggccgtgtcc aatatgctgc agaaggcccg ccagacactg     1140

gagttttacc cttgtacctc tgaggagatc gaccacgagg atatcacaaa ggataagacc     1200

agcacagtgg aggcctgcct gccactggag ctgaccaaga acgagagctg tctgaattcc     1260

agggagacat ctttcatcac caacggcagc tgcctggcct ccagaaagac atcttttatg     1320

atggccctgt gcctgtctag catctacgag gacctgaaga tgtatcaggt ggagttcaag     1380

accatgaacg ccaagctgct gatggaccct aagaggcaga tctttctgga tcagaatatg     1440

ctggccgtga tcgacgagct gatgcaggcc ctgaacttca attccgagac agtgccacag     1500

aagtcctctc tggaggagcc cgatttctac aagaccaaga tcaagctgtg catcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagagtga tgagctatct gaacgccagc     1620

gagtccagga gagtgcggcg caacaagagg agcaagggcg tgcaggtgga gacaatcagc     1680

cccggcgatg gccggacctt tcctaagcgc ggccagacat gcgtggtgca ctacaccggc     1740

atgctgggcg acggcaagaa ggtggacagc tccagggata gaaacaagcc attcaagttt     1800

atgctgggca agcaggaagt gatcagagga tgggaggagg gagtggcaca gatgtccgtg     1860

ggacagggcg ccaagctgac aatctctcca gattacgcat atggagcaac cggacaccca     1920

ggaatcatcc caccccacgc caccctggtg ttcgacgtgg agctgctgga gctggagtga     1980


<210>  614
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  614

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  615
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  615

Glu Phe Ser Thr Glu Phe 
1               5       


<210>  616
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  616

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  617
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  617
atgtaccgaa tgcaactgct gagctgcatc gccctgagcc tggcactcgt gaccaacagc       60


<210>  618
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  618
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210>  619
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  619
atgtacagga tgcagctgct gagctgcatc gccctgagcc tggccctggt gaccaacagc       60


<210>  620
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal Sequence

<400>  620
atgtacagaa tgcagctgct gagctgcatc gccctgtccc tcgccctggt gaccaactcc       60


<210>  621
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  621
gagttcagca ccgagttt                                                     18


<210>  622
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  622
gagttctcca ccgagttc                                                     18


<210>  623
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  623
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttattca atctatgcat       60

attgatgcta ctttatatac ggaaagtgat gttcacccca gttgcaaagt aacagcaatg      120

aagtgctttc tcttggagtt acaagttatt tcacttgagt ccggagatgc aagtattcat      180

gatacagtag aaaatctgat catcctagca aacaacagtt tgtcttctaa tgggaatgta      240

acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa aaaatattaa agaatttttg      300

cagagttttg tacatattgt ccaaatgttc atcaacactt cttga                      345


<210>  624
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  624
aactgggtga acgtgatctc cgacctgaag aagatcgagg acctgatcca gtccatgcac       60

atcgacgcca ccctgtacac cgagagcgac gtgcacccta gctgcaaggt gaccgccatg      120

aagtgcttcc tgctggagct gcaggtgatc agcctggaga gcggcgatgc cagcatccac      180

gacacagtgg agaacctgat catcctggcc aacaacagcc tgagcagcaa cggcaatgtg      240

accgagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttcctg      300

cagtccttcg tgcacatcgt gcagatgttc atcaacacca gctaa                      345


<210>  625
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  625
aactgggtca acgtgatcag cgacctgaag aagatcgagg acctcatcca gtccatgcac       60

attgacgcca ccctgtacac cgagtccgat gtgcacccta gctgcaaggt gaccgccatg      120

aaatgcttcc tgctggagct gcaggtcatc tccttagaaa gcggcgatgc ctccatccac      180

gacaccgtgg agaacctgat catcctggcc aataactccc tgagcagcaa cggcaacgtg      240

accgagagcg gctgcaaaga gtgtgaagag ctggaggaga agaacattaa ggagttcctg      300

cagagcttcg tgcacatcgt gcaaatgttc atcaacacca gctaa                      345


<210>  626
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  626
aactgggtga acgtgatctc cgacctgaaa aagatcgagg atttgatcca gagcatgcac       60

attgacgcca ccctgtatac cgagtccgac gtgcacccga gttgcaaggt gactgccatg      120

aagtgcttcc tgctggagct gcaagtgatc agcctggaga gcggcgacgc cagcatccac      180

gacaccgtgg aaaaccttat cattctggcc aacaatagcc tgagcagcaa cggcaacgtg      240

accgaaagcg gatgtaagga atgcgaggaa ctggaagaga agaatatcaa agaattcctg      300

caaagcttcg tgcacatcgt gcagatgttc atcaacactt ct                         342


<210>  627
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  627
atctctctga ttgcggcgct ggcagttgac cacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgtttacgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta caaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgttga         477


<210>  628
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  628
atgtacagga tgcagctgct gagctgcatc gccctgagcc tggccctggt gaccaacagc       60

aactgggtga acgtgatctc cgacctgaag aagatcgagg acctgatcca gtccatgcac      120

atcgacgcca ccctgtacac cgagagcgac gtgcacccta gctgcaaggt gaccgccatg      180

aagtgcttcc tgctggagct gcaggtgatc agcctggaga gcggcgatgc cagcatccac      240

gacacagtgg agaacctgat catcctggcc aacaacagcc tgagcagcaa cggcaatgtg      300

accgagagcg gctgcaagga gtgcgaggag ctggaggaga agaacatcaa ggagttcctg      360

cagtccttcg tgcacatcgt gcagatgttc atcaacacca gctaa                      405


<210>  629
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  629
atgtacagaa tgcagctgct gagctgcatc gccctgtccc tcgccctggt gaccaactcc       60

gagttctcca ccgagttcat ctccctgatc gccgccctgg ccgtggatta tgtgatcggc      120

atggagaacg ccatgccctg gaatctgccc gccgacctgg cctggttcaa gaggaatacc      180

ctgaacaagc ccgtcatcat gggcaggcac acctgggaaa gcatcggcag acccctgccc      240

ggcaggaaga acatcatcct gtccagccag cccggcaccg acgacagagt gacctgggtg      300

aagagcgtgg acgaagctat cgccgcttgc ggcgacgtgc ccgagatcat ggtgatcggc      360

ggcggcaggg tgatcgaaca gttcctgccc aaggcccaga agctgtacct gacccacatc      420

gatgccgagg tggaaggcga tacacacttc cccgattacg aacctgacga ctgggaaagc      480

gtgttttccg aattccacga cgccgacgcc cagaacagcc acagctactg cttcgagatc      540

ctggaaagaa ggggaggctc cggcggaaac tgggtcaacg tgatcagcga cctgaagaag      600

atcgaggacc tcatccagtc catgcacatt gacgccaccc tgtacaccga gtccgatgtg      660

caccctagct gcaaggtgac cgccatgaaa tgcttcctgc tggagctgca ggtcatctcc      720

ttagaaagcg gcgatgcctc catccacgac accgtggaga acctgatcat cctggccaat      780

aactccctga gcagcaacgg caacgtgacc gagagcggct gcaaagagtg tgaagagctg      840

gaggagaaga acattaagga gttcctgcag agcttcgtgc acatcgtgca aatgttcatc      900

aacaccagct aa                                                          912


<210>  630
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  630

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  631
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  631

Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
            20                  25      


<210>  632
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  632

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210>  633
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  633

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Ile Ser Leu 
385                 390                 395                 400 


Ile Ala Ala Leu Ala Val Asp His Val Ile Gly Met Glu Asn Ala Met 
                405                 410                 415     


Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu 
            420                 425                 430         


Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg 
        435                 440                 445             


Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr 
    450                 455                 460                 


Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala 
465                 470                 475                 480 


Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Tyr 
                485                 490                 495     


Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp 
            500                 505                 510         


Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Lys Pro Asp Asp 
        515                 520                 525             


Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser 
    530                 535                 540                 


His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
545                 550                 555 


<210>  634
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  634

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Gly Val Gln 
385                 390                 395                 400 


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
                405                 410                 415     


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp Gly Lys Lys 
            420                 425                 430         


Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
        435                 440                 445             


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
    450                 455                 460                 


Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
465                 470                 475                 480 


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
                485                 490                 495     


Asp Val Glu Leu Leu Glu Leu Glu 
            500                 


<210>  635
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  635

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
385                 390                 395 


<210>  636
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  636

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Ile Ser Leu 
385                 390                 395                 400 


Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala Met 
                405                 410                 415     


Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu 
            420                 425                 430         


Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg 
        435                 440                 445             


Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr 
    450                 455                 460                 


Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala 
465                 470                 475                 480 


Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Ile 
                485                 490                 495     


Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp 
            500                 505                 510         


Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp Asp 
        515                 520                 525             


Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser 
    530                 535                 540                 


His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
545                 550                 555 


<210>  637
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  637
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagc             54


<210>  638
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  638
tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca       60

ggaggaggga gcttgcaa                                                     78


<210>  639
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  639
atcacgtgcc ctccccccat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc       60

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc      120

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt      180

ctcaaatgca ttagagaccc tgccctggtt caccaaaggc cagcgccacc ctccacagta      240

acgacggcag gggtgacccc acagccagag agcctctccc cttctggaaa agagcccgca      300

gcttcatctc ccagctcaaa caacacagcg gccacaacag cagctattgt cccgggctcc      360

cagctgatgc cttcaaaatc accttccaca ggaaccacag agataagcag tcatgagtcc      420

tcccacggca ccccctctca gacaacagcc aagaactggg aactcacagc atccgcctcc      480

caccagccgc caggtgtgta tccacagggc cacagcgaca ccactgtggc tatctccacg      540

tccactgtcc tgctgtgtgg gctgagcgct gtgtctctcc tggcatgcta cctcaagtca      600

aggcaaactc ccccgctggc cagcgttgaa atggaagcca tggaggctct gccggtgact      660

tgggggacca gcagcagaga tgaagacttg gaaaactgct ctcaccacct atga            714


<210>  640
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  640
attacctgcc cccctccgat gagcgtggag cacgccgaca tctgggtcaa gagctacagc       60

ttgtatagta gggagcggta catctgtaac agcgggttca agaggaaggc cgggaccagc      120

tcactgaccg agtgcgtgtt gaacaaggcc accaacgtgg cccactggac cacccctagc      180

cttaagtgca tcagggaccc agcgctcgta caccagagac ccgcgcctcc ctctacggta      240

accacggcag gcgtaacccc ccagcccgag agcctgtccc cgagcggcaa ggagcctgca      300

gcgagcagcc cctcaagcaa caacacagcc gctaccaccg cggcaatcgt gcccggcagc      360

cagctgatgc cctcaaagag ccccagcacc ggcaccactg agataagcag ccacgagagc      420

tcacacggca ctccctcaca gaccactgcc aagaattggg agctgaccgc ctctgccagc      480

caccagcccc caggcgtgta tccccagggc cacagcgaca ccacggtcgc catcagcaca      540

tctacagtgc ttttgtgcgg ccttagcgcc gtgtcactgc tggcatgcta cttgaaaagt      600

aggcaaactc cccctcttgc cagtgtggaa atggaggcca tggaagccct gcccgtgacc      660

tggggcacca gttctaggga cgaggacctt gagaactgct cacatcattt g               711


<210>  641
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  641
atctctctga ttgcggcgct ggcagttgac tacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgttatcgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta cgaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgt            474


<210>  642
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  642
atctctctga ttgcggcgct ggcagttgac cacgttattg gcatggaaaa cgcgatgcca       60

tggaacctcc cggctgacct ggcgtggttc aaacgtaaca ccctgaacaa acctgtgatc      120

atgggtcgtc acacctggga atctattggc cgtcctctcc cgggtcgtaa aaacatcatt      180

ctgtcttctc agccaggcac cgacgaccgt gttacctggg ttaaaagcgt tgacgaagcg      240

attgctgcgt gcggtgatgt tcctgaaatt atggtgatcg gcggtggccg tgtttacgaa      300

cagttcctgc cgaaagcgca gaaactgtac ctgacccaca tcgacgcgga agttgaaggt      360

gacacccact tcccggacta caaaccggat gattgggaga gcgtattctc cgaattccat      420

gatgcggatg cgcaaaactc tcattcttac tgttttgaaa tcctggaacg tcgt            474


<210>  643
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  643
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg catctctctg     1200

attgcggcgc tggcagttga ccacgttatt ggcatggaaa acgcgatgcc atggaacctc     1260

ccggctgacc tggcgtggtt caaacgtaac accctgaaca aacctgtgat catgggtcgt     1320

cacacctggg aatctattgg ccgtcctctc ccgggtcgta aaaacatcat tctgtcttct     1380

cagccaggca ccgacgaccg tgttacctgg gttaaaagcg ttgacgaagc gattgctgcg     1440

tgcggtgatg ttcctgaaat tatggtgatc ggcggtggcc gtgtttacga acagttcctg     1500

ccgaaagcgc agaaactgta cctgacccac atcgacgcgg aagttgaagg tgacacccac     1560

ttcccggact acaaaccgga tgattgggag agcgtattct ccgaattcca tgatgcggat     1620

gcgcaaaact ctcattctta ctgttttgaa atcctggaac gtcgttga                  1668


<210>  644
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  644
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg cggcgtgcag     1200

gttgagacta taagcccagg cgacggcagg accttcccca agaggggcca gacatgcgtg     1260

gtgcactaca ccggcatgct tggcgacggc aaaaaggtgg actcaagcag ggacaggaac     1320

aagcccttca agttcatgtt gggcaaacag gaggtgatca gaggctggga ggagggtgtt     1380

gcccagatga gcgtggggca gggcgccaag ctcacgataa gtcccgatta cgcctacggc     1440

gccaccggtc accccggcat catcccccca cacgccaccc tggtgttcga cgtggaattg     1500

ctggagctgg agtga                                                      1515


<210>  645
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  645
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgtga                  1188


<210>  646
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  646
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg catctctctg     1200

attgcggcgc tggcagttga ctacgttatt ggcatggaaa acgcgatgcc atggaacctc     1260

ccggctgacc tggcgtggtt caaacgtaac accctgaaca aacctgtgat catgggtcgt     1320

cacacctggg aatctattgg ccgtcctctc ccgggtcgta aaaacatcat tctgtcttct     1380

cagccaggca ccgacgaccg tgttacctgg gttaaaagcg ttgacgaagc gattgctgcg     1440

tgcggtgatg ttcctgaaat tatggtgatc ggcggtggcc gtgttatcga acagttcctg     1500

ccgaaagcgc agaaactgta cctgacccac atcgacgcgg aagttgaagg tgacacccac     1560

ttcccggact acgaaccgga tgattgggag agcgtattct ccgaattcca tgatgcggat     1620

gcgcaaaact ctcattctta ctgttttgaa atcctggaac gtcgttga                  1668


<210>  647
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  647
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg cgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt tattaaggaa     1560

ttcatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210>  648
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  648
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagcgg cgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttcttcagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

ttccgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt tattaaggaa     1560

gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210>  649
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  649

Gly Gly Ser Gly 
1               


<210>  650
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  650
ggaggatctg ga                                                           12


<210>  651
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  651

Gly Gly Ser Gly Gly Gly 
1               5       


<210>  652
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  652
ggtggctctg gtggtggt                                                     18


<210>  653
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  653
ggaggtagtg gtggaggc                                                     18


<210>  654
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  654

Ser Gly Gly Gly Ser 
1               5   


<210>  655
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  655
tcaggtggcg gtagt                                                        15


<210>  656
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  656

Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   


<210>  657
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  657
ggaggtagtg gtggaggcag tggtgga                                           27


<210>  658
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  658

Gly Gly Gly Gly Gly 
1               5   


<210>  659
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  659

Gly Gly Gly Gly Ser 
1               5   


<210>  660
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  660

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  661
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  661

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  662
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  662

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  663
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  663

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  664
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  664

Ser Ser Ser Ser Gly 
1               5   


<210>  665
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  665

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10  


<210>  666
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  666

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10                  15  


<210>  667
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  667

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly 
            20  


<210>  668
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  668

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Ser Ser Gly 
            20                  25  


<210>  669
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  669

Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser 
1               5                   10                  15      


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
            20                  25                  30  


<210>  670
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  670
agcggcggtg gcagc                                                        15


<210>  671
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  671

Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser 
1               5                   10          


<210>  672
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  672

Gly Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  15  


<210>  673
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  673

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Ser Glu Gly Ser Gly Ser 
1               5                   10                  15      


Thr Lys Gly 
            


<210>  674
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  674

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  675
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  675

Val Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Asp 
1               5                   10              


<210>  676
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  676
gtcgactatc cctacgatgt tccggactac gcactggac                              39


<210>  677
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  677

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Glu Phe 
1               5                   10                  


<210>  678
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  678
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattacgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aatcatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  679
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  679
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

acggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  680
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  680
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaata acgttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  681
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  681
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tatttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gttattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  682
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  682
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtg cagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacgc gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  683
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  683
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gctattaagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  684
<211>  311
<212>  PRT
<213>  Renilla reniformis

<400>  684

Met Thr Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln 
305                 310     


<210>  685
<211>  936
<212>  DNA
<213>  Renilla reniformis

<400>  685
atgacttcca aggtgtacga ccccgagcaa cgcaaacgca tgatcactgg gcctcagtgg       60

tgggctcgct gcaagcaaat gaacgtgctg gactccttca tcaactacta tgattccgag      120

aagcacgccg agaacgccgt gatttttctg catggtaacg ctgcctccag ctacctgtgg      180

aggcacgtcg tgcctcacat cgagcccgtg gctagatgca tcatccctga tctgatcgga      240

atgggtaagt ccggcaagag cgggaatggc tcatatcgcc tcctggatca ctacaagtac      300

ctcaccgctt ggttcgagct gctgaacctt ccaaagaaaa tcatctttgt gggccacgac      360

tggggggctt gtctggcctt tcactactcc tacgagcacc aagacaagat caaggccatc      420

gtccatgctg agagtgtcgt ggacgtgatc gagtcctggg acgagtggcc tgacatcgag      480

gaggatatcg ccctgatcaa gagcgaagag ggcgagaaaa tggtgcttga gaataacttc      540

ttcgtcgaga ccatgctccc aagcaagatc atgcggaaac tggagcctga ggagttcgct      600

gcctacctgg agccattcaa ggagaagggc gaggttagac ggcctaccct ctcctggcct      660

cgcgagatcc ctctcgttaa gggaggcaag cccgacgtcg tccagattgt ccgcaactac      720

aacgcctacc ttcgggccag cgacgatctg cctaagatgt tcatcgagtc cgaccctggg      780

ttcttttcca acgctattgt cgagggagct aagaagttcc ctaacaccga gttcgtgaag      840

gtgaagggcc tccacttcag ccaggaggac gctccagatg aaatgggtaa gtacatcaag      900

agcttcgtgg agcgcgtgct gaagaacgag cagtaa                                936


<210>  686
<211>  550
<212>  PRT
<213>  Photinus pyralis

<400>  686

Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ser Lys Leu 
545                 550 


<210>  687
<211>  1653
<212>  DNA
<213>  Photinus pyralis

<400>  687
atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg       60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc      120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc      180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg      240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg      300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc      360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa      420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc      480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac      540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc      600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt      660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg      720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt      780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat      840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc      900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc      960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac     1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc     1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag     1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc     1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc     1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc     1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa     1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg     1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac     1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac     1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt     1620

aaggccaaga agggcggcaa gagcaagctg tga                                  1653


<210>  688
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  688

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  689
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  689

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Gly Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  690
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  690

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Glu Asn Asp 
            180                 185     


<210>  691
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  691

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Phe Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  692
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  692

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Phe Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Phe 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  693
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  693

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  694
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  694

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly Arg Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Gly Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  695
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  695

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  696
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  696

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  697
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  697

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Trp Val Gly Gly Val 
        35                  40                  45              


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    50                  55                  60                  


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
65                  70                  75                  80  


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                85                  90                  95      


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105     


<210>  698
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  698

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210>  699
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  699

Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
1               5                   10                  15      


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
            20                  25                  30          


Trp Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
        35                  40                  45              


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
    50                  55                  60                  


Tyr Cys Asn His Arg Asn Arg Arg Arg 
65                  70              


<210>  700
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  700

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  701
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  701

Ile Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu 
1               5                   10                  15      


Ile Val Gly Ala Val Phe Leu Cys Ala Arg Arg 
            20                  25          


<210>  702
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  702

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  703
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  703

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys Lys Asp 
225                 230             


<210>  704
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  704

Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu Val Thr 
1               5                   10                  15      


Gly Ala Phe Gly Phe 
            20      


<210>  705
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  705

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu 
            20      


<210>  706
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  706

Val Gly Trp Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val 
1               5                   10                  15      


Leu Ala Val Ile 
            20  


<210>  707
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  707

Phe Trp Ala Leu Val Val Val Ala Gly Val Leu Phe Cys Tyr Gly Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Leu Cys Val Ile Trp Thr 
            20                  25          


<210>  708
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  708
gagtaattca tacaaaagga ctcgcccctg ccttggggaa tcccagggac cgtcgttaaa       60

ctcccactaa cgtagaaccc agagatcgct gcgttcccgc cccctcaccc gcccgctctc      120

gtcatcactg aggtggagaa gagcatgcgt gaggctccgg tgcccgtcag tgggcagagc      180

gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga accggtgcct      240

agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc      300

ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca      360

acgggtttgc cgccagaaca caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct      420

ttacgggtta tggcccttgc gtgccttgaa ttacttccac gcccctggct gcagtacgtg      480

attcttgatc ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa      540

ggagcccctt cgcctcgtgc ttgagttgag gcctggcttg ggcgctgggg ccgccgcgtg      600

cgaatctggt ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa      660

aatttttgat gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc      720

caagatctgc acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg      780

tcccagcgca catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg      840

gggtagtctc aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc      900

ccgccctggg cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg      960

cttcccggcc ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg     1020

ggtgagtcac ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac     1080

tccacggagt accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg     1140

tcgtctttag gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg     1200

gagactgaag ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt     1260

gagtttggat cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca     1320

tttcaggtgt cgtga                                                      1335


<210>  709
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  709
tcaggcgggg ggagt                                                        15


<210>  710
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  710
ggaggaggag gatccggagg aggaggatct ggcggcggcg gcagc                       45


<210>  711
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  711
ggaggaggag gatccggagg aggaggatct ggcggaggag gcagc                       45


<210>  712
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  712
ggaggaggag gaagcggagg aggaggatcc ggcggaggag gctct                       45


<210>  713
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  713
ggaggaggag gcagcggagg aggaggttct ggaggaggcg gcagc                       45


<210>  714
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  714
ggcggcggcg gctctggagg aggaggcagc ggcggaggag gctcc                       45


<210>  715
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  715
ggaggaggag gcagcggcgg aggaggctcc ggcggcggcg gctct                       45


<210>  716
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  716
tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca       60

ggtggaggca gcttgcaa                                                     78


<210>  717
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  717
tccggtggag gtagcggtgg agggggttct ggtggaggag gttctggagg tggaggttct       60

ggcggtgggt ccttgcaa                                                     78


<210>  718
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  718
tctggcggag gaagcggagg cggaggatct ggtggtggtg gatctggcgg cggtggtagt       60

ggcggaggtt ctctgcaa                                                     78


<210>  719
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  719
tccggggggg gtagcggggg agggggttcc ggcgggggag ggtctggagg gggaggttcc       60

ggcggggggt ccttgcaa                                                     78


<210>  720
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  720
tctggcggag gatctggagg aggcggatct ggaggaggag gcagtggagg cggaggatct       60

ggcggaggat ctctgcag                                                     78


<210>  721
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  721

Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser 
        


<210>  722
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  722

Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  723
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  723
tctggtggcg ggagtggagg aggtgggtcc ggagggggag ggagcggtgg tggaggttcc       60

ggcggggggg gtagtggagg cggagggtca ggtgggggca gc                         102


<210>  724
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  724
agtggtggcg ggtccggcgg tggtggtagc gggggtggag gctcaggtgg cggtggcagt       60


<210>  725
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Cleavable Peptide

<400>  725

Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  726
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Cleavable Peptide

<400>  726
ggagctacta acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct       60


<210>  727
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  727
tctagataat acgactcact agagatcc                                          28


<210>  728
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  728
tatggccaca accatg                                                       16


<210>  729
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  729
aatctagata atacgactca ctagagatcc                                        30


<210>  730
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  730
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagc             54


<210>  731
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  731
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagc             54


<210>  732
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  732

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly 
            20                  25                  30  


<210>  733
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  733
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc                                        90


<210>  734
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  734
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcgt cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  735
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  735
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggtcctcc      180

attcctgaga agaaccgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  736
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  736
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga aggatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  737
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  737
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

agggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  738
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  738
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccaggagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagt aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  739
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  739
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgta tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tagagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  740
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  740
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcata      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  741
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  741
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg aggagaatga t                                                561


<210>  742
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  742
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtaattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaggtatatg agaaggatga t                                                561


<210>  743
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  743
atggttggtt cgctaaaccg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatgcc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  744
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  744
atggttggtt cgctaaactg catcgttgtt gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ttattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  745
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  745
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcgg tagaaggtaa acagaatctg gtgattatgg gtaagaaggc ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agagctaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  746
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  746
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag gatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttcttag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtt tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc cgtcttaaac tatttgtgac aaggatcatg      420

caagactttg gaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  747
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  747
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat acttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgag aaggatcatg      420

caagaccttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  748
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  748
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gcacaaattt      540

ggagtatatg agaagaatga t                                                561


<210>  749
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  749
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggagcctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagacttcg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtacatg aggagaatga t                                                561


<210>  750
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  750
atggttggtt cgctaaactg catcgccgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaaggc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcta gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  751
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  751
atggttggtt cgctaaactg cgtcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttgaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatgcc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  752
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  752
atggttggct cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggactcgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gcttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaatg taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  753
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  753
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcgagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcatcttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtctataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

ggagtatatg agaagaatga t                                                561


<210>  754
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  754
atggttggtt cgctgaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcctcag tagaaggtaa gcagaatctg gtgattatgc gtaagaagac ctggttctcc      180

attcctgaga agaatagacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ccattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggttagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcgtg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctgtgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaggtatatg agaagaatga t                                                561


<210>  755
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  755
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat acttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagtcctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagca gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttatgac gaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgacc tggagaaata taaactcctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattag gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  756
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  756
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acaggatctg gtgattatgg gtaagaagac ctggtcctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tgtttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattggtt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  757
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  757
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

gaggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agagttaatt tagttcttag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttcc      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggcgttct ctctgatgtc caggaggaga aaggcactaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  758
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  758
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ccattttctc tccagaagtc tggatgatgc cctaaaacct      300

actggacgat caggattagc agataaagta gacatggccc ggatagttgg cggcagctct      360

gtttgtaagg aagccataag gtacccaggc caccctaagc tacctgtgac aaggaccatg      420

caagactttg aaagtgacac gtctcttcca gaagttgcct tggagaagta taagcttctg      480

ccagaatacc caggtgtgct ctctggtgcc caggaggaga agggcgctag gtacaagttt      540

gaagcatacg aaaggagtga t                                                561


<210>  759
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  759
atggctggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcggat atttccggag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaacct      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga agggcattaa gtacaaattt      540

gaagtatatg agaggaatga t                                                561


<210>  760
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  760
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgagcgt cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat attttcagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcatcttctt tccagaagtc tagatggtgc cttaaaactt      300

actgagcaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttatgagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcgtg      420

caagactttg agagtggcac gtttttccca gaaattgatt tggagagata taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  761
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  761
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atctccaggg aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga aggctcgacc ttcagagggt ggaattaatt tagttctcag tagagaaccc      240

aaggaacctc cacaaggagc tcatttcctt tccagaagtc tagatgatgc cttaggactt      300

actgaacaac cggaattagc aaataaagta gacatggtct ggatagttga tggcagctct      360

gtttataagg aagccatgaa tcacccaggc caccctaaac tatttgtgac aagggtcata      420

caaggctttg aaagtggcac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccagaatacc caggtgttct ctctgacgtc caggagggga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatgg t                                                561


<210>  762
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  762
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcaa cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tggatgatgc ctcaagactt      300

actgaacaac cagaattagc caataaagta gacacagtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca ggaattgatt tggagaaata taaacttctg      480

ccaggatacc caggtgttct ctctgatgtc cagggggaga aaggcattaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  763
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  763
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac agggatcatg      420

caaggctctg aaagtgacac gttttttcca gaaattgatt tggagagata tgaacttctg      480

ccaggatacc caggtgctct ctctgatgtt caggaggaga aaggcattga gtgcaaattt      540

gaagtatatg aggagagtga c                                                561


<210>  764
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  764
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagagctc      240

agggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaagacct      300

actggacaac cagaattagc agataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataggg aagccatgaa tcgcccaggc catcttaaac tgtttgtaac aaggatcatg      420

caaggctttg aaagtgacac gttttttcca gaaattgatt tggagaaata taagcttctg      480

ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaactt      540

gaagtgtatg aggagaatga t                                                561


<210>  765
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  765
atggttggtt cgctaaactg catcgtcgct gtgtcccaga gcatgggcat cggcaagaac       60

ggggacctgt cctggccacc gctcaggaat gaattcagat atctccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattacgg gtaaggagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaatcaatt tagtcctcag cagagagctc      240

aaggaacctc cacaaggagc tcattttctt tccgggggtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgag ttacccaggc catcttaaac tacttgtgac aaggatcatg      420

caagactctg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacctccg      480

ccagaatacc caggtgttct ctctgatgtc caggaggcga aaggcattaa gtacaaactt      540

gaagtatatg agaagaatga t                                                561


<210>  766
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  766
atggctggtt cgctaaactg catcgtcgct gtgtcccaga atatgggcgt cggcaagaac       60

ggggacctgc cctggccacc gctcagggat ggattcagat atttccggag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggtcctcc      180

attcctgaga agaatcgacc tttagagggt agaactaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc ttatcttctt tccagaagtc tagatgatgc cttaaaactt      300

actgagcagc cagaattagc agatgaagca ggcatggtct gggtagttgg tggcagttct      360

gttgataagg aagccatgaa tcacccaggc catcccaaac tatctgtgac aaggatcgtg      420

caagactttg gaagtgacgc gttttttcca gaaattgatt tggagaaatg caaacttctg      480

ccagaatacc caggtgttct ctctgatgcc caggaggaga gaggcattaa gtacaaattt      540

gaagtatacg agaagagtga c                                                561


<210>  767
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  767
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gcccaggcat gaattcagat atttccagag agtgaccaca      120

acctcttcag cagaaggtaa acagaatctg gtgattatgg gcaagaagac ctggttctcc      180

atccctgaga agaatcgacc ttcaaagggt agaattggtt tagttctcag cggagaactc      240

aaggaacctc cacagggagc ccactttctc tccaggagtc tagatgatac cttaagactt      300

actgaacaac cagaattaac gaatagagta aacatggtct ggatagttgg tggcagttct      360

gtttataagg aggccatgaa tcacccaggc caccttagac cagttgtgac aaggatcatg      420

caggactttg aaagcgacgc gttttttcca gaagttgact tggagaaata tagacttcta      480

ccagaatacc caggtgttct ctctgatgtc cagggggaga aaggcattaa gtacaaattt      540

gaagcatata ggaagaatga t                                                561


<210>  768
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  768
atggttggct cgctaaactg catcgtcact gtgtcccgga gcatgggcat cggcaaggac       60

ggggacctgt cctggccacc gctcaggagt gaattcaggt actttcagag aacgaccgca      120

acctcttcag tagaaggtag acagagtctg gtgatcatgg gcaagaggac ctggttctcc      180

actcctgaga ggaatcgacc cttaaggggt agagctaact tagttctcag cggagagctc      240

aagggacctc cacaaggagc tcatcttctt tccagaagtc tagatggtgc cttaaaactt      300

actgaacagc cagagttagc agataaagta gacgtggtcc ggatagttgg tggcagttct      360

gttgatgagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aagagtcatg      420

cggggctttg aaagtgatac gctttttcca ggaatcgact tggggaaacg taaacttctg      480

ccagaatacc caggtgttct ctctgatgtc cgggaggaga aaggcattaa gtacaaactt      540

gaagtatgtg ggaataat                                                    558


<210>  769
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  769
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgtcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  770
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  770
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

ggatacccag gtgttctctc tgatgtccag gaggagaaag gctttaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210>  771
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  771
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

ggatacccag gtgttctctc tgatgtccag gaggagaaag gctttaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210>  772
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  772
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgagg agaatgat                                                    558


<210>  773
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  773
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaat tcatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210>  774
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  774
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaat tcatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  775
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  775
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tcttcagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaagt tccgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgattg a                                                561


<210>  776
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  776
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tcttcagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaagt tccgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  777
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  777
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgtatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  778
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  778
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcatcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggcaga cttaaactat ttgtgacaag gatcatgcaa      420

gactttggaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  779
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  779
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgtcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  780
<211>  561
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  780
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac       60

ggggacctgc cctggccacc gctcaggaat gaattcagat atttccagag aatgaccaca      120

acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc      180

attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc      240

aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt      300

actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct      360

gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg      420

caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg      480

ccaggatacc caggtgttct ctctgatgtc caggaggaga aaggctttaa gtacaaattt      540

gaagtatatg agaagaatga t                                                561


<210>  781
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  781

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Lys Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  782
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  782
acaacaaccc cagcacccag acctccaaca cctgcaccaa ccatcgcaag ccagcctctg       60

tccctgaggc ccgaggcatg taggccagca gcaggaggcg ccgtgcacac ccggggcctg      120

gactttgcct gcgatatcta tatctgggca ccactggcag gaacatgtgg cgtgctgctg      180

ctgtccctgg tcatcaccct gtattgc                                          207


<210>  783
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  783
accacaaccc cagcaccccg cccaccaaca cctgcaccaa ccatcgcctc ccagccactg       60

tctctgaggc ccgaggcatg taggcctgca gcaggaggcg ccgtgcacac caggggcctg      120

gactttgcct gcgatatcta catctgggca cctctggcag gaacatgtgg cgtgctgctg      180

ctgtccctgg tcatcaccct gtattgc                                          207


<210>  784
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  784
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  785
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  785
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  786
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  786
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  787
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  787
ggcgtgcagg tggagacaat cagcccaggc gacggacgca cctttccaaa gaggggacag       60

acatgcgtgg tgcactacac cggcatgctg gaggatggca agaaggtgga ctcctctaga      120

gatcggaata agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      180

gagggagtgg cacagatgtc tgtgggacag cgggccaagc tgacaatcag ccctgactat      240

gcatacggag caaccggaca cccaggaatc atcccaccac acgccacact ggtgttcgat      300

gtggagctgc tgaagcctga g                                                321


<210>  788
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  788
atctccctga tcgccgccct ggcagtggac tacgtgatcg gcatggagaa cgccatgccc       60

tggaatctgc ctgccgatct ggcctggttt aagagaaaca cactgaataa gcccgtgatc      120

atgggccggc acacctggga gtctatcggc aggcccctgc ctggcaggaa gaacatcatc      180

ctgtcctctc agcctggcac agacgataga gtgacctggg tgaagagcgt ggacgaggca      240

atcgcagcat gtggcgatgt gcccgagatc atggtcatcg gcggcggcag agtgatcgag      300

cagttcctgc ctaaggccca gaagctgtat ctgacacaca tcgacgccga ggtggagggc      360

gacacccact ttccagatta cgagcccgac gattgggagt ccgtgttctc tgagtttcac      420

gacgccgatg cccagaattc ccactcttat tgcttcgaga tcctggagag gaga            474


<210>  789
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  789
ggagtgcagg tggagacaat ctccccaggc gacggcagaa cctttcccaa gcggggccag       60

acatgcgtgg tgcactatac cggcatgctg gaggatggca agaaggtgga ctcctctaga      120

gatcggaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      180

gagggagtgg cacagatgtc tgtgggacag cgggccaagc tgacaatcag cccagactat      240

gcatacggag caaccggaca ccctggaatc atccctccac acgccaccct ggtgttcgat      300

gtggagctgc tgaagcctga g                                                321


<210>  790
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  790
atctacatct gggcaccact ggcaggaaca tgcggcgtgc tgctgctgtc cctggtcatc       60

accctgtatt gt                                                           72


<210>  791
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  791
atctccctga tcgccgccct ggcagtggac tacgtgatcg gcatggagaa cgccatgccc       60

tggaatctgc ctgccgatct ggcctggttt aagagaaaca cactgaataa gcccgtgatc      120

atgggccggc acacctggga gagcatcggc agacctctgc caggccggaa gaacatcatc      180

ctgtcctctc agcctggcac agacgataga gtgacctggg tgaagtccgt ggacgaggca      240

atcgcagcat gcggcgatgt gcccgagatc atggtcatcg gcggcggcag agtgatcgag      300

cagttcctgc ctaaggccca gaagctgtat ctgacacaca tcgacgccga ggtggagggc      360

gacacccact ttccagatta cgagcccgac gattgggagt ccgtgttctc tgagtttcac      420

gacgccgatg cccagaattc ccactcttat tgtttcgaga tcctggagag aaga            474


<210>  792
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  792
atctacatct gggcacctct ggcaggaaca tgcggcgtgc tgctgctgtc tctggtcatc       60

accctgtatt gt                                                           72


<210>  793
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  793
atctccctga tcgccgccct ggcagtggac cacgtgatcg gcatggagaa cgccatgcca       60

tggaatctgc ccgccgatct ggcctggttc aagcggaaca ccctgaataa gccagtgatc      120

atgggcagac acacatggga gtctatcggc aggcccctgc ctggacgcaa gaacatcatc      180

ctgagctccc agcccggcac cgacgatagg gtgacatggg tgaagtccgt ggacgaggca      240

atcgcagcat gcggcgatgt gcccgagatc atggtcatcg gcggcggcag agtgtacgag      300

cagttcctgc ctaaggccca gaagctgtat ctgacccaca tcgacgccga ggtggagggc      360

gacacacact ttcctgatta caagccagac gattgggagt ccgtgttctc tgagtttcac      420

gacgccgatg cccagaattc tcacagctat tgttttgaga tcctggagcg gaga            474


<210>  794
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  794
ggagtgcagg tggagacaat cagcccaggc gacggaagga cattcccaaa gaggggacag       60

acctgcgtgg tgcactacac aggcatgctg ggcgatggca agaaggtgga cagctcccgg      120

gatagaaaca agcccttcaa gtttatgctg ggcaagcagg aagtgatcag gggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgaccatctc tcctgactac      240

gcctatggag caacaggaca cccaggaatc atcccacctc acgccaccct ggtgtttgat      300

gtggagctgc tggagctgga g                                                321


<210>  795
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  795
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttcagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgat                                                    558


<210>  796
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  796
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttcagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagt tcatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgat                                                    558


<210>  797
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  797
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttaagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgat                                                    558


<210>  798
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  798
gtgggctccc tgaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttttcaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaagt tccgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgat                                                    558


<210>  799
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  799
cgcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg       60

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc      120

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa      180

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga      240

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc      300

ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc      360

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac      420

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg      480

tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac      540

ggggacgtgg ttttcctttg aaaaacacga tgataa                                576


<210>  800
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  800
gcttgccaca acccacaagg agacgacctt cc                                     32


<210>  801
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  801
aattgggtca acgtgatcag cgacctgaag aagatcgagg acctgatcca gagcatgcac       60

atcgacgcca cactgtacac cgagtccgat gtgcacccta gctgcaaagt gaccgccatg      120

aagtgctttc tgctggaact gcaagtgatc agcctggaaa gcggcgacgc cagcatccac      180

gataccgtgg aaaatctgat catcctggcc aacaacagcc tgagcagcaa cggcaatgtg      240

accgagagcg gctgcaaaga gtgcgaggaa ctggaagaga agaacatcaa agagttcctc      300

cagagcttcg tccacatcgt gcagatgttc atcaacacca gc                         342


<210>  802
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  802
tctggcggag gaagcggagg cggaggatct ggtggtggtg gatctggcgg cggtggtagt       60

ggcggaggtt ctctgcaa                                                     78


<210>  803
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  803
atcacctgtc ctccacctat gagcgtggaa cacgccgaca tctgggtcaa gagctacagc       60

ctgtacagca gagagcggta catctgcaac agcggcttca agagaaaggc cggcacaagc      120

agcctgaccg agtgtgtgct gaacaaggcc acaaacgtgg cccactggac cacacctagc      180

ctgaagtgca tcagagatcc cgctctggtt caccagaggc ctgctcctcc atctacagtg      240

acaacagctg gcgtgacccc tcagcctgag tctctgtctc catctggaaa agagcctgcc      300

gccagctctc ccagctctaa caatactgct gccaccacag ccgccatcgt gcctggatct      360

cagctgatgc ctagcaagag ccctagcacc ggcacaacag agatcagctc tcacgagtct      420

agccacggca ccccatctca gaccacagcc aagaattggg agctgaccgc ctctgcctct      480

catcagccac ctggtgttta ccctcaaggc cactctgata ccaccgtggc catcagcaca      540

agcacagtgc tgctgtgtgg actgtctgcc gtgtctctgc tggcctgcta cctgaagtct      600

agacagacac ctcctctggc cagcgtggaa atggaagcca tggaagctct gcctgtgaca      660

tggggcacca gcagcagaga tgaggacctc gagaattgca gccaccacct g               711


<210>  804
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  804

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  805
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  805

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Gly Ser Gly Gly Val Gly Ser Leu Asn 
                485                 490                 495     


Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp 
            500                 505                 510         


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met 
        515                 520                 525             


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
    530                 535                 540                 


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly 
545                 550                 555                 560 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
                565                 570                 575     


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
            580                 585                 590         


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
        595                 600                 605             


Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu 
    610                 615                 620                 


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
625                 630                 635                 640 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
                645                 650                 655     


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
            660                 665                 670         


Tyr Glu Lys Asn Asp 
        675         


<210>  806
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  806

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser 
                485             


<210>  807
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  807

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Ser 
            500                 505             


<210>  808
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  808

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Ile 
            20                  25                  30          


Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg 
        35                  40                  45              


Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
    50                  55                  60                  


Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr His 
65                  70                  75                  80  


Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp 
            100                 105                 110         


Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr Phe 
        115                 120                 125             


Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser Gly 
145                 150                 155                 160 


Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val 
                165                 170                 175     


Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro 
            180                 185                 190         


Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr 
        195                 200                 205             


Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp 
    210                 215                 220                 


Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp 
225                 230                 235                 240 


Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser 
                245                 250                 255     


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly 
                485                 490                 495     


Ser 
    


<210>  809
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  809

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Ser Gly Glu Ser Arg Arg Val Arg Arg Asn 
                485                 490                 495     


Lys Arg Ser Lys Gly Ser 
            500         


<210>  810
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  810

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  811
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  811
agaaacctgc ctgtcgctac ccccgacccc ggaatgttcc cctgcctgca ccactcccag       60

aacctcctga gggccgtgtc caacatgctg cagaaggcta gacagaccct cgaattctac      120

ccctgtacca gcgaggagat cgaccatgag gacatcacca aggataagac cagcaccgtg      180

gaggcttgcc tgcctctgga gctgaccaaa aacgagagct gcctgaacag cagggaaacc      240

agcttcatta ccaacggctc ctgcctggcc tccaggaaga catccttcat gatggccctg      300

tgcctcagca gcatctacga ggacctgaag atgtatcagg tggagtttaa gaccatgaat      360

gccaagctgc tgatggaccc taagaggcag atcttcctgg accagaatat gctggccgtg      420

attgacgagc tgatgcaggc cctcaacttt aacagcgaga ccgtgcccca gaaaagcagc      480

ctcgaagagc ctgacttcta caaaaccaag attaagctgt gtatcctgct gcacgccttc      540

aggatcaggg ccgtgaccat cgacagggtg atgagctacc tgaacgccag t               591


<210>  812
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  812
ggagtgcagg tggagacaat cagccccggc gatggcagga cctttcctaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctcccgg      120

gatagaaata agcccttcaa gtttatgctg ggcaagcagg aagtgatcag aggctgggag      180

gagggagtgg cacagatgtc tgtgggacag ggcgccaagc tgacaatcag cccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga g                                                321


<210>  813
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  813

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  814
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  814

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Leu Ser Lys Gly 
            500                 505                 510         


Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val 
        515                 520                 525             


His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu 
    530                 535                 540                 


Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val 
545                 550                 555                 560 


Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln 
                565                 570                 575     


Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro 
            580                 585                 590         


Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val 
        595                 600                 605             


Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser 
    610                 615                 620                 


Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn 
625                 630                 635                 640 


Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu 
                645                 650                 655     


Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu 
            660                 665                 670         


Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu 
        675                 680                 685             


Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala 
    690                 695                 700                 


Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr 
705                 710                 715                 720 


Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly 
                725                 730                 735     


Gly Met Asp Glu Leu Tyr Lys 
            740             


<210>  815
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  815

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Asn Trp Val Asn 
            500                 505                 510         


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
        515                 520                 525             


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
    530                 535                 540                 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
545                 550                 555                 560 


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
                565                 570                 575     


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
            580                 585                 590         


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
        595                 600                 605             


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro Met Ser 
                645                 650                 655     


Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg 
            660                 665                 670         


Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser 
        675                 680                 685             


Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp 
    690                 695                 700                 


Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln 
705                 710                 715                 720 


Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln 
                725                 730                 735     


Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro 
            740                 745                 750         


Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser 
        755                 760                 765             


Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser 
    770                 775                 780                 


Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn 
785                 790                 795                 800 


Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro 
                805                 810                 815     


Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu 
            820                 825                 830         


Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser 
        835                 840                 845             


Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala 
    850                 855                 860                 


Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn 
865                 870                 875                 880 


Cys Ser His His Leu 
                885 


<210>  816
<211>  907
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  816

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu 
            500                 505                 510         


Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe Leu Leu 
        515                 520                 525             


Ile Pro Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
    530                 535                 540                 


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
545                 550                 555                 560 


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
                565                 570                 575     


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
            580                 585                 590         


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
        595                 600                 605             


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
    610                 615                 620                 


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
625                 630                 635                 640 


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
            660                 665                 670         


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        675                 680                 685             


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    690                 695                 700                 


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
705                 710                 715                 720 


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                725                 730                 735     


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            740                 745                 750         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        755                 760                 765             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    770                 775                 780                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
785                 790                 795                 800 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                805                 810                 815     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            820                 825                 830         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        835                 840                 845             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    850                 855                 860                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
865                 870                 875                 880 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                885                 890                 895     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            900                 905         


<210>  817
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  817

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Trp Thr 
            500                 505                 510         


Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Asn Trp 
        515                 520                 525             


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
    530                 535                 540                 


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
545                 550                 555                 560 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
                565                 570                 575     


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
            580                 585                 590         


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
        595                 600                 605             


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
    610                 615                 620                 


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro 
            660                 665                 670         


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
        675                 680                 685             


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
    690                 695                 700                 


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
705                 710                 715                 720 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
                725                 730                 735     


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
            740                 745                 750         


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
        755                 760                 765             


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
    770                 775                 780                 


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
785                 790                 795                 800 


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
                805                 810                 815     


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
            820                 825                 830         


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
        835                 840                 845             


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
    850                 855                 860                 


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
865                 870                 875                 880 


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
                885                 890                 895     


Glu Asn Cys Ser His His Leu 
            900             


<210>  818
<211>  4031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  818
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggtg aggatcccgc ccctctccct cccccccccc taacgttact     1500

ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata     1560

ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt     1620

cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa     1680

gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag     1740

cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca     1800

cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc     1860

aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat     1920

tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta     1980

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga     2040

taagcttgcc acaacccaca aggagacgac cttccatgtg ccaccagcag ctggtcatca     2100

gctggttctc cctggtgttt ctggcatccc cactggtggc aatctgggag ctgaagaagg     2160

acgtgtacgt ggtggagctg gactggtatc ccgatgcccc tggcgagatg gtggtgctga     2220

cctgcgacac acctgaggag gatggcatca cctggacact ggatcagagc tccgaggtgc     2280

tgggaagcgg caagaccctg acaatccagg tgaaggagtt cggcgacgcc ggccagtaca     2340

catgtcacaa gggcggcgag gtgctgtctc acagcctgct gctgctgcac aagaaggagg     2400

acggcatttg gtccacagac atcctgaagg atcagaagga gccaaagaac aagaccttcc     2460

tgcggtgcga ggccaagaat tatagcggcc ggttcacctg ttggtggctg accacaatca     2520

gcaccgatct gacattttcc gtgaagtcta gccggggctc ctctgaccca cagggagtga     2580

catgcggagc agccaccctg tccgccgagc gggtgagagg cgataacaag gagtacgagt     2640

attccgtgga gtgccaggag gactctgcct gtcctgcagc agaggagagc ctgccaatcg     2700

aagtgatggt ggatgccgtg cacaagctga agtacgagaa ttatacaagc tccttcttta     2760

tcagggacat catcaagcct gatcccccta agaacctgca gctgaagcca ctgaagaatt     2820

ctcgccaggt ggaggtgagc tgggagtacc cagacacctg gtccacaccc cactcttatt     2880

tcagcctgac cttttgcgtg caggtgcagg gcaagtccaa gcgggagaag aaggacagag     2940

tgttcaccga taagacatct gccaccgtga tctgtcggaa gaacgcctcc atctctgtga     3000

gggcccagga tcgctactat tctagctcct ggagcgagtg ggcatccgtg ccatgttctg     3060

gaggaggagg aagcggagga ggaggatccg gcggaggagg ctctagaaat ctgccagtgg     3120

caacccctga cccaggaatg ttcccttgcc tgcaccacag ccagaacctg ctgagggccg     3180

tgtccaatat gctgcagaag gcccgccaga cactggagtt ttacccttgt accagcgagg     3240

agatcgacca cgaggatatc acaaaggata agacctccac agtggaggcc tgcctgccac     3300

tggagctgac caagaacgag agctgtctga attcccggga gacatctttc atcaccaacg     3360

gcagctgcct ggcctccaga aagacatctt ttatgatggc cctgtgcctg tctagcatct     3420

acgaggacct gaagatgtat caggtggagt tcaagaccat gaacgccaag ctgctgatgg     3480

accctaagag gcagatcttt ctggatcaga atatgctggc cgtgatcgac gagctgatgc     3540

aggccctgaa cttcaatagc gagacagtgc cacagaagtc ctctctggag gagcccgatt     3600

tctacaagac caagatcaag ctgtgcatcc tgctgcacgc ctttaggatc cgcgccgtga     3660

ccatcgaccg cgtgatgtct tatctgaacg catccggagg atctggagga gtgcaggtgg     3720

agacaatcag ccccggcgat ggcaggacct ttcctaagcg cggccagaca tgcgtggtgc     3780

actacaccgg catgctgggc gacggcaaga aggtggacag ctcccgggat agaaataagc     3840

ccttcaagtt tatgctgggc aagcaggaag tgatcagagg ctgggaggag ggagtggcac     3900

agatgtctgt gggacagggc gccaagctga caatcagccc agattacgca tatggagcaa     3960

ccggacaccc aggaatcatc ccaccccacg ccaccctggt gttcgacgtg gagctgctgg     4020

agctggagtg a                                                          4031


<210>  819
<211>  3698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  819
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggtg aggatcccgc ccctctccct cccccccccc taacgttact     1500

ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt ttccaccata     1560

ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt gacgagcatt     1620

cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa     1680

gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag     1740

cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt ataagataca     1800

cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc     1860

aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa ggtaccccat     1920

tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta gtcgaggtta     1980

aaaaaacgtc taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga     2040

taagcttgcc acaacccaca aggagacgac cttccatgtg ccaccaacag ctcgtgatca     2100

gctggttctc cctggtgttc ctggctagcc ccctggtggc catctgggag ctcaagaaag     2160

acgtgtacgt ggtggaactg gactggtacc ccgacgcccc tggcgaaatg gtggtgctga     2220

catgcgacac ccctgaggag gatggcatta cctggaccct cgatcagagc tccgaggtgc     2280

tgggcagcgg caaaaccctg accatccagg tgaaggagtt tggcgatgcc ggccagtaca     2340

catgtcacaa gggcggcgag gtgctgagcc actccctgct gctgctccac aagaaggaag     2400

atggcatctg gagcaccgac attctgaagg atcagaagga gcccaagaac aagacattcc     2460

tgaggtgtga ggccaagaac tacagcggca ggtttacctg ctggtggctg acaacaatca     2520

gcaccgacct cacattctcc gtcaagtcct ccaggggttc ttccgaccct caaggcgtga     2580

catgcggcgc tgccaccctg agcgctgaga gagtcagggg cgacaacaag gagtacgagt     2640

acagcgtcga atgtcaggag gacagcgcct gtcccgccgc tgaagagagc ctgcctatcg     2700

aggtgatggt ggacgccgtg cacaaactga agtatgagaa ttacacctcc agcttcttca     2760

tcagggacat catcaaaccc gatcccccca agaacctgca gctgaagcct ctgaagaaca     2820

gcagacaggt cgaagtgtcc tgggagtacc ctgatacctg gtccacaccc cacagctact     2880

tcagcctgac cttttgcgtg caggtgcagg gcaagagcaa aagggagaag aaggacaggg     2940

tgtttaccga caagacctcc gccacagtga tttgcagaaa gaacgcctcc atcagcgtga     3000

gggcccagga caggtattac agcagctcct ggagcgaatg ggctagcgtg ccctgtagcg     3060

gaggaggagg cagcggagga ggaggttctg gaggaggcgg cagcagaaac ctgcctgtcg     3120

ctacccccga ccccggaatg ttcccctgcc tgcaccactc ccagaacctc ctgagggccg     3180

tgtccaacat gctgcagaag gctagacaga ccctcgaatt ctacccctgt accagcgagg     3240

agatcgacca tgaggacatc accaaggata agaccagcac cgtggaggct tgcctgcctc     3300

tggagctgac caaaaacgag agctgcctga acagcaggga aaccagcttc attaccaacg     3360

gctcctgcct ggcctccagg aagacatcct tcatgatggc cctgtgcctc agcagcatct     3420

acgaggacct gaagatgtat caggtggagt ttaagaccat gaatgccaag ctgctgatgg     3480

accctaagag gcagatcttc ctggaccaga atatgctggc cgtgattgac gagctgatgc     3540

aggccctcaa ctttaacagc gagaccgtgc cccagaaaag cagcctcgaa gagcctgact     3600

tctacaaaac caagattaag ctgtgtatcc tgctgcacgc cttcaggatc agggccgtga     3660

ccatcgacag ggtgatgagc tacctgaacg ccagctaa                             3698


<210>  820
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  820
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggtg a                                               1461


<210>  821
<211>  2034
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  821
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg aggcagcgga ggagtgggct ccctgaactg catcgtggcc     1500

gtgagccaga acatgggcat cggcaagaat ggcgacctgc cttggccacc tctgaggaac     1560

gagttcagat actttcagag gatgaccaca accagctccg tggagggcaa gcagaacctg     1620

gtcatcatgg gcaagaagac atggttctct atccccgaga agaaccgccc tctgaagggc     1680

cggatcaatc tggtgctgag cagagagctg aaggagccac cacagggagc acacttcctg     1740

agccggagcc tggacgatgc cctgaagctg accgagcagc ccgagctggc caacaaggtg     1800

gacatggtgt ggatcgtggg cggctctagc gtgatcaagg aggccatgaa tcacccaggc     1860

cacctgaagc tgttcgtgac aagaatcatg caggactttg agtccgatac cttctttccc     1920

gagatcgacc tggagaagta caagctgctg cctgagtatc caggcgtgct gtctgatgtg     1980

caggaggaga agggcatcaa gtacaagttc gaggtgtatg agaagaatga ttga           2034


<210>  822
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  822
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg atcctga                                         1467


<210>  823
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic HA Tag

<400>  823

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  824
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic HA Tag

<400>  824
tacccatacg atgttccaga ttacgct                                           27


<210>  825
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic HA Tag

<400>  825
tatccttacg atgtgcccga ctatgct                                           27


<210>  826
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic HA Tag

<400>  826
tatccgtacg acgtaccaga ctacgca                                           27


<210>  827
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  827
ggagtgcagg tggaaaccat ctccccagga gacgggcgca ccttccccaa gcgcggccag       60

acctgcgtgg tgcactacac cgggatgctt ggagatggaa agaaagttga ctcctcccgg      120

gacagaaaca agccctttaa gtttatgcta ggcaagcagg aggtgatccg aggctgggaa      180

gaaggggttg cccagatgag tgtgggtcag ggagccaaac tgactatatc tccagattat      240

gcctatggtg ccactgggca cccaggcatc atcccaccac atgccactct cgtcttcgat      300

gtggagcttc tagaactgga a                                                321


<210>  828
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  828

Leu Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210>  829
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  829
ttgagcaagg gcgaggagga caacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggcggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgccgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagctgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgagcgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaag                      705


<210>  830
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  830

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  831
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  831
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atccca                                                                  66


<210>  832
<211>  1527
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  832
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     1500

gaggagaacc ctggacctgg atcctga                                         1527


<210>  833
<211>  1494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  833
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

ccctatcctt acgatgtgcc cgactatgct gacatccaga tgacacagac cacaagctcc      120

ctgtccgcct ctctgggcga cagagtgacc atcagctgcc gggcctccca ggatatctct      180

aagtatctga actggtacca gcagaagccc gatggcacag tgaagctgct gatctatcac      240

accagccgcc tgcactccgg agtgccttct aggttcagcg gctccggctc tggcacagac      300

tacagcctga ccatctccaa cctggagcag gaggatatcg ccacctattt ctgccagcag      360

ggcaatacac tgccttacac ctttggcggc ggcacaaagc tggagatcac cggaggagga      420

ggcagcggag gaggaggctc cggcggcggc ggctctgagg tgaagctgca ggagtccgga      480

ccaggcctgg tggcacctag ccagtccctg tctgtgacat gtaccgtgtc cggcgtgtct      540

ctgccagact acggcgtgtc ttggatcagg cagccaccta ggaagggcct ggagtggctg      600

ggcgtgatct ggggcagcga gacaacatac tataattctg ccctgaagag cagactgaca      660

atcatcaagg acaacagcaa gtcccaggtg ttcctgaaga tgaatagcct gcagacagac      720

gataccgcca tctactattg cgccaagcac tactattacg gcggcagcta tgccatggat      780

tactggggcc agggcacatc cgtgaccgtg tctagcacca caaccccagc acctcgccca      840

ccaacaccag caccaaccat cgcatcccag ccactgtctc tgaggcccga ggcatgtagg      900

cctgcagcag gaggcgccgt gcacaccagg ggcctggact ttgcctgcga tatctatatc      960

tgggcaccac tggcaggaac atgtggcgtg ctgctgctgt ccctggtcat caccctgtat     1020

tgcaagagag gccggaagaa gctgctgtac atcttcaagc agcccttcat gaggcccgtg     1080

cagacaaccc aggaggagga cggctgcagc tgtcggttcc cagaggagga ggagggagga     1140

tgtgagctga gggtgaagtt ttctaggagc gccgatgcac cagcatataa gcagggacag     1200

aaccagctgt acaacgagct gaatctgggc aggagagagg agtacgacgt gctggataag     1260

aggaggggaa gggaccccga gatgggaggc aagccaagga gaaagaaccc ccaggagggc     1320

ctgtataatg agctgcagaa ggacaagatg gccgaggcct actccgagat cggcatgaag     1380

ggagagcggc gcaggggcaa gggacacgat ggcctgtatc agggcctgtc tacagccacc     1440

aaggacacct acgatgcact gcacatgcag gccctgcctc caaggggatc ctga           1494


<210>  834
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  834
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggag tggtgagtcc aggagagtgc ggcgcaacaa gaggagcaag     1500

ggatcctga                                                             1509


<210>  835
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  835
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  836

<400>  836
000

<210>  837
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  837
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggtg a                                               1461


<210>  838
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  838
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atccggagct actaacttca gcctgctgaa gcaggctgga     1500

gacgtggagg agaaccctgg acctttgagc aagggcgagg aggacaacat ggccatcatc     1560

aaggagttca tgcgcttcaa ggtgcacatg gagggctccg tgaacggcca cgagttcgag     1620

atcgagggcg agggcgaggg ccgcccctac gagggcaccc agaccgccaa gctgaaggtg     1680

accaagggcg gccccctgcc cttcgcctgg gacatcctgt cccctcagtt catgtacggc     1740

tccaaggcct acgtgaagca ccccgccgac atccccgact acttgaagct gtccttcccc     1800

gagggcttca agtgggagcg cgtgatgaac ttcgaggacg gcggcgtggt gaccgtgacc     1860

caggactcct ccctgcagga cggcgagttc atctacaagg tgaagctgcg cggcaccaac     1920

ttcccctccg acggccccgt aatgcagaag aagaccatgg gctgggaggc ctcctccgag     1980

cggatgtacc ccgaggacgg cgccctgaag ggcgagatca agcagaggct gaagctgaag     2040

gacggcggcc actacgacgc cgaggtcaag accacctaca aggccaagaa gcccgtgcag     2100

ctgcccggcg cctacaacgt caacatcaag ctggacatca cctcccacaa cgaggactac     2160

accatcgtgg aacagtacga gcgcgccgag ggccgccact ccaccggcgg catggacgag     2220

ctgtacaagt aa                                                         2232


<210>  839
<211>  2658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  839
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg ttcaggagct actaacttca gcctgctgaa gcaggctgga     1500

gacgtggagg agaaccctgg acctaactgg gtgaacgtga tctccgacct gaaaaagatc     1560

gaggatttga tccagagcat gcacattgac gccaccctgt ataccgagtc cgacgtgcac     1620

ccgagttgca aggtgactgc catgaagtgc ttcctgctgg agctgcaagt gatcagcctg     1680

gagagcggcg acgccagcat ccacgacacc gtggaaaacc ttatcattct ggccaacaat     1740

agcctgagca gcaacggcaa cgtgaccgaa agcggatgta aggaatgcga ggaactggaa     1800

gagaagaata tcaaagaatt cctgcaaagc ttcgtgcaca tcgtgcagat gttcatcaac     1860

acttcttcag gtggcggtag tggtggggga ggatctggag gcggaggaag cgggggtgga     1920

ggttcaggag gagggagctt gcaaattacc tgcccccctc cgatgagcgt ggagcacgcc     1980

gacatctggg tcaagagcta cagcttgtat agtagggagc ggtacatctg taacagcggg     2040

ttcaagagga aggccgggac cagctcactg accgagtgcg tgttgaacaa ggccaccaac     2100

gtggcccact ggaccacccc tagccttaag tgcatcaggg acccagcgct cgtacaccag     2160

agacccgcgc ctccctctac ggtaaccacg gcaggcgtaa ccccccagcc cgagagcctg     2220

tccccgagcg gcaaggagcc tgcagcgagc agcccctcaa gcaacaacac agccgctacc     2280

accgcggcaa tcgtgcccgg cagccagctg atgccctcaa agagccccag caccggcacc     2340

actgagataa gcagccacga gagctcacac ggcactccct cacagaccac tgccaagaat     2400

tgggagctga ccgcctctgc cagccaccag cccccaggcg tgtatcccca gggccacagc     2460

gacaccacgg tcgccatcag cacatctaca gtgcttttgt gcggccttag cgccgtgtca     2520

ctgctggcat gctacttgaa aagtaggcaa actccccctc ttgccagtgt ggaaatggag     2580

gccatggaag ccctgcccgt gacctggggc accagttcta gggacgagga ccttgagaac     2640

tgctcacatc atttgtga                                                   2658


<210>  840
<211>  2724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  840
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg ttcaggagct actaacttca gcctgctgaa gcaggctgga     1500

gacgtggagg agaaccctgg acctatgctt ctcctggtga caagccttct gctctgtgag     1560

ttaccacacc cagcattcct cctgatccca aactgggtga acgtgatctc cgacctgaaa     1620

aagatcgagg atttgatcca gagcatgcac attgacgcca ccctgtatac cgagtccgac     1680

gtgcacccga gttgcaaggt gactgccatg aagtgcttcc tgctggagct gcaagtgatc     1740

agcctggaga gcggcgacgc cagcatccac gacaccgtgg aaaaccttat cattctggcc     1800

aacaatagcc tgagcagcaa cggcaacgtg accgaaagcg gatgtaagga atgcgaggaa     1860

ctggaagaga agaatatcaa agaattcctg caaagcttcg tgcacatcgt gcagatgttc     1920

atcaacactt cttcaggtgg cggtagtggt gggggaggat ctggaggcgg aggaagcggg     1980

ggtggaggtt caggaggagg gagcttgcaa attacctgcc cccctccgat gagcgtggag     2040

cacgccgaca tctgggtcaa gagctacagc ttgtatagta gggagcggta catctgtaac     2100

agcgggttca agaggaaggc cgggaccagc tcactgaccg agtgcgtgtt gaacaaggcc     2160

accaacgtgg cccactggac cacccctagc cttaagtgca tcagggaccc agcgctcgta     2220

caccagagac ccgcgcctcc ctctacggta accacggcag gcgtaacccc ccagcccgag     2280

agcctgtccc cgagcggcaa ggagcctgca gcgagcagcc cctcaagcaa caacacagcc     2340

gctaccaccg cggcaatcgt gcccggcagc cagctgatgc cctcaaagag ccccagcacc     2400

ggcaccactg agataagcag ccacgagagc tcacacggca ctccctcaca gaccactgcc     2460

aagaattggg agctgaccgc ctctgccagc caccagcccc caggcgtgta tccccagggc     2520

cacagcgaca ccacggtcgc catcagcaca tctacagtgc ttttgtgcgg ccttagcgcc     2580

gtgtcactgc tggcatgcta cttgaaaagt aggcaaactc cccctcttgc cagtgtggaa     2640

atggaggcca tggaagccct gcccgtgacc tggggcacca gttctaggga cgaggacctt     2700

gagaactgct cacatcattt gtga                                            2724


<210>  841
<211>  2712
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  841
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaagggg atccggagct actaacttca gcctgctgaa gcaggctgga     1500

gacgtggagg agaaccctgg acctatggac tggacctgga ttctgtttct ggtggccgct     1560

gccacaagag tgcacagcaa ttgggtcaac gtgatcagcg acctgaagaa gatcgaggac     1620

ctgatccaga gcatgcacat cgacgccaca ctgtacaccg agtccgatgt gcaccctagc     1680

tgcaaagtga ccgccatgaa gtgctttctg ctggaactgc aagtgatcag cctggaaagc     1740

ggcgacgcca gcatccacga taccgtggaa aatctgatca tcctggccaa caacagcctg     1800

agcagcaacg gcaatgtgac cgagagcggc tgcaaagagt gcgaggaact ggaagagaag     1860

aacatcaaag agttcctcca gagcttcgtc cacatcgtgc agatgttcat caacaccagc     1920

tctggcggag gaagcggagg cggaggatct ggtggtggtg gatctggcgg cggtggtagt     1980

ggcggaggtt ctctgcaaat cacctgtcct ccacctatga gcgtggaaca cgccgacatc     2040

tgggtcaaga gctacagcct gtacagcaga gagcggtaca tctgcaacag cggcttcaag     2100

agaaaggccg gcacaagcag cctgaccgag tgtgtgctga acaaggccac aaacgtggcc     2160

cactggacca cacctagcct gaagtgcatc agagatcccg ctctggttca ccagaggcct     2220

gctcctccat ctacagtgac aacagctggc gtgacccctc agcctgagtc tctgtctcca     2280

tctggaaaag agcctgccgc cagctctccc agctctaaca atactgctgc caccacagcc     2340

gccatcgtgc ctggatctca gctgatgcct agcaagagcc ctagcaccgg cacaacagag     2400

atcagctctc acgagtctag ccacggcacc ccatctcaga ccacagccaa gaattgggag     2460

ctgaccgcct ctgcctctca tcagccacct ggtgtttacc ctcaaggcca ctctgatacc     2520

accgtggcca tcagcacaag cacagtgctg ctgtgtggac tgtctgccgt gtctctgctg     2580

gcctgctacc tgaagtctag acagacacct cctctggcca gcgtggaaat ggaagccatg     2640

gaagctctgc ctgtgacatg gggcaccagc agcagagatg aggacctcga gaattgcagc     2700

caccacctgt ag                                                         2712


<210>  842
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  842

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser Val Gly 
    530                 535                 540                 


Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val Gly Lys 
545                 550                 555                 560 


Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe 
                565                 570                 575     


Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val 
            580                 585                 590         


Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro 
        595                 600                 605             


Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro 
    610                 615                 620                 


Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys 
625                 630                 635                 640 


Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile 
                645                 650                 655     


Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His 
            660                 665                 670         


Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr 
        675                 680                 685             


Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr 
    690                 695                 700                 


Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys 
705                 710                 715                 720 


Phe Glu Val Tyr Glu Lys Asn Asp 
                725             


<210>  843
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  843

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Glu Ser Arg 
    530                 535                 540                 


Arg Val Arg Arg Asn Lys Arg Ser Lys Gly Ser Val Gly Ser Leu Asn 
545                 550                 555                 560 


Cys Ile Val Ala Val Ser Gln Asn Met Gly Val Gly Lys Asn Gly Asp 
                565                 570                 575     


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met 
            580                 585                 590         


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
        595                 600                 605             


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly 
    610                 615                 620                 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
625                 630                 635                 640 


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
                645                 650                 655     


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
            660                 665                 670         


Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu 
        675                 680                 685             


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
    690                 695                 700                 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
705                 710                 715                 720 


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
                725                 730                 735     


Tyr Glu Lys Asn Asp 
            740     


<210>  844
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  844

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser Val Gly 
    530                 535                 540                 


Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys 
545                 550                 555                 560 


Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe 
                565                 570                 575     


Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val 
            580                 585                 590         


Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro 
        595                 600                 605             


Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro 
    610                 615                 620                 


Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys 
625                 630                 635                 640 


Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile 
                645                 650                 655     


Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His 
            660                 665                 670         


Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr 
        675                 680                 685             


Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr 
    690                 695                 700                 


Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys 
705                 710                 715                 720 


Phe Glu Val Tyr Glu Lys Asn Asp 
                725             


<210>  845
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  845

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Glu Ser Arg 
    530                 535                 540                 


Arg Val Arg Arg Asn Lys Arg Ser Lys Gly Ser Val Gly Ser Leu Asn 
545                 550                 555                 560 


Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp 
                565                 570                 575     


Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met 
            580                 585                 590         


Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly 
        595                 600                 605             


Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly 
    610                 615                 620                 


Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly 
625                 630                 635                 640 


Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu 
                645                 650                 655     


Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val Gly Gly 
            660                 665                 670         


Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly His Leu Lys Leu 
        675                 680                 685             


Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro 
    690                 695                 700                 


Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val 
705                 710                 715                 720 


Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val 
                725                 730                 735     


Tyr Glu Lys Asn Asp 
            740     


<210>  846
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  846

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser 
    530                 535                 540         


<210>  847
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  847
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagt     1620

ggatccgttg gttcgctaaa ctgcatcgtc gctgtgtccc agaacatggg cgtcggcaag     1680

aacggggacc tgccctggcc accgctcagg aatgaattca gatatttcca gagaatgacc     1740

acaacctctt cagtagaagg taaacagaat ctggtgatta tgggtaagaa gacctggttc     1800

tccattcctg agaagaatcg acctttaaag ggtagaatta atttagttct cagcagagaa     1860

ctcaaggaac ctccacaagg agctcatttt ctttccagaa gtctagatga tgccttaaaa     1920

cttactgaac aaccagaatt agcaaataaa gtagacatgg tctggatagt tggtggcagt     1980

tctgtttata aggaagccat gaatcaccca ggccatctta aactatttgt gacaaggatc     2040

atgcaagact ttgaaagtga cacgtttttt ccagaaattg atttggagaa atataaactt     2100

ctgccagaat acccaggtgt tctctctgat gtccaggagg agaaaggcat taagtacaaa     2160

tttgaagtat atgagaagaa tgattaa                                         2187


<210>  848
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  848
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagt     1620

ggtgagtcca ggagagtgcg gcgcaacaag aggagcaagg gatccgttgg ttcgctaaac     1680

tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct gccctggcca     1740

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1800

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1860

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1920

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1980

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     2040

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     2100

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     2160

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     2220

gattaa                                                                2226


<210>  849
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  849
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagt     1620

ggatccgttg gttcgctaaa ctgcatcgtc gctgtgtccc agaacatggg catcggcaag     1680

aacggggacc tgccctggcc accgctcagg aatgaattca gatatttcca gagaatgacc     1740

acaacctctt cagtagaagg taaacagaat ctggtgatta tgggtaagaa gacctggttc     1800

tccattcctg agaagaatcg acctttaaag ggtagaatta atttagttct cagcagagaa     1860

ctcaaggaac ctccacaagg agctcatttt ctttccagaa gtctagatga tgccttaaaa     1920

cttactgaac aaccagaatt agcaaataaa gtagacatgg tctggatagt tggtggcagt     1980

tctgttatta aggaagccat gaatcaccca ggccatctta aactatttgt gacaaggatc     2040

atgcaagact ttgaaagtga cacgtttttt ccagaaattg atttggagaa atataaactt     2100

ctgccagaat acccaggtgt tctctctgat gtccaggagg agaaaggcat taagtacaaa     2160

tttgaagtat atgagaagaa tgattaa                                         2187


<210>  850
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  850
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagt     1620

ggtgagtcca ggagagtgcg gcgcaacaag aggagcaagg gatccgttgg ttcgctaaac     1680

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1740

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1800

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1860

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1920

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1980

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgttattaa ggaagccatg     2040

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     2100

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     2160

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     2220

gattaa                                                                2226


<210>  851
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  851
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagt     1620

ggatcctaa                                                             1629


<210>  852
<211>  2574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  852
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaacaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc accgacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagtggatcc gcaaccaatt ttagtctact taaacaagca     1020

ggtgatgtag aagaaaatcc aggtccaatg tggccccctg ggtcagcctc ccagccaccg     1080

ccctcacctg ccgcggccac aggtctgcat ccagcggctc gccctgtgtc cctgcagtgc     1140

cggctcagca tgtgtccagc gcgcagcctc ctccttgtgg ctaccctggt cctcctggac     1200

cacctcagtt tggccagaaa cctccccgtg gccactccag acccaggaat gttcccatgc     1260

cttcaccact cccaaaacct gctgagggcc gtcagcaaca tgctccagaa ggccagacaa     1320

actctagaat tttacccttg cacttctgaa gagattgatc atgaagatat cacaaaagat     1380

aaaaccagca cagtggaggc ctgtttacca ttggaattaa ccaagaatga gagttgccta     1440

aattccagag agacctcttt cataactaat gggagttgcc tggcctccag aaagacctct     1500

tttatgatgg ccctgtgcct tagtagtatt tatgaagact tgaagatgta ccaggtggag     1560

ttcaagacca tgaatgcaaa gcttctgatg gaccctaaga ggcagatctt tctagatcaa     1620

aacatgctgg cagttattga tgagctgatg caggccctga atttcaacag tgagactgtg     1680

ccacaaaaat cctcccttga agaaccggat ttttataaaa ctaaaatcaa gctctgcata     1740

cttcttcatg ctttcagaat tcgggcagtg actattgata gagtgatgag ctatctgaat     1800

gcttccggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct     1860

ggacctttga gcaagggcga ggaggacaac atggccatca tcaaggagtt catgcgcttc     1920

aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag     1980

ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg cggccccctg     2040

cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag     2100

caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag     2160

cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag     2220

gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc     2280

gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac     2340

ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac     2400

gccgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac     2460

gtcaacatca agctggacat cacctcccac aacgaggact acaccatcgt ggaacagtac     2520

gagcgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaa           2574


<210>  853
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  853
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggat ccggagctac taacttcagc      420

ctgctgaagc aggctggaga cgtggaggag aaccctggac ctttgagcaa gggcgaggag      480

gacaacatgg ccatcatcaa ggagttcatg cgcttcaagg tgcacatgga gggctccgtg      540

aacggccacg agttcgagat cgagggcgag ggcgagggcc gcccctacga gggcacccag      600

accgccaagc tgaaggtgac caagggcggc cccctgccct tcgcctggga catcctgtcc      660

cctcagttca tgtacggctc caaggcctac gtgaagcacc ccgccgacat ccccgactac      720

ttgaagctgt ccttccccga gggcttcaag tgggagcgcg tgatgaactt cgaggacggc      780

ggcgtggtga ccgtgaccca ggactcctcc ctgcaggacg gcgagttcat ctacaaggtg      840

aagctgcgcg gcaccaactt cccctccgac ggccccgtaa tgcagaagaa gaccatgggc      900

tgggaggcct cctccgagcg gatgtacccc gaggacggcg ccctgaaggg cgagatcaag      960

cagaggctga agctgaagga cggcggccac tacgacgccg aggtcaagac cacctacaag     1020

gccaagaagc ccgtgcagct gcccggcgcc tacaacgtca acatcaagct ggacatcacc     1080

tcccacaacg aggactacac catcgtggaa cagtacgagc gcgccgaggg ccgccactcc     1140

accggcggca tggacgagct gtacaagtaa                                      1170


<210>  854
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  854
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggtt ccgttggttc gctaaactgc      420

atcgtcgctg tgtcccagaa catgggcatc ggcaagaacg gggacctgcc ctggccaccg      480

ctcaggaatg aattcagata tttccagaga atgaccacaa cctcttcagt agaaggtaaa      540

cagaatctgg tgattatggg taagaagacc tggttctcca ttcctgagaa gaatcgacct      600

ttaaagggta gaattaattt agttctcagc agagaactca aggaacctcc acaaggagct      660

cattttcttt ccagaagtct agatgatgcc ttaaaactta ctgaacaacc agaattagca      720

aataaagtag acatggtctg gatagttggt ggcagttctg ttattaagga agccatgaat      780

cacccaggcc atcttaaact atttgtgaca aggatcatgc aagactttga aagtgacacg      840

ttttttccag aaattgattt ggagaaatat aaacttctgc cagaataccc aggtgttctc      900

tctgatgtcc aggaggagaa aggcattaag tacaaatttg aagtatatga gaagaatgat      960

ggatccggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct     1020

ggacctttga gcaagggcga ggaggacaac atggccatca tcaaggagtt catgcgcttc     1080

aaggtgcaca tggagggctc cgtgaacggc cacgagttcg agatcgaggg cgagggcgag     1140

ggccgcccct acgagggcac ccagaccgcc aagctgaagg tgaccaaggg cggccccctg     1200

cccttcgcct gggacatcct gtcccctcag ttcatgtacg gctccaaggc ctacgtgaag     1260

caccccgccg acatccccga ctacttgaag ctgtccttcc ccgagggctt caagtgggag     1320

cgcgtgatga acttcgagga cggcggcgtg gtgaccgtga cccaggactc ctccctgcag     1380

gacggcgagt tcatctacaa ggtgaagctg cgcggcacca acttcccctc cgacggcccc     1440

gtaatgcaga agaagaccat gggctgggag gcctcctccg agcggatgta ccccgaggac     1500

ggcgccctga agggcgagat caagcagagg ctgaagctga aggacggcgg ccactacgac     1560

gccgaggtca agaccaccta caaggccaag aagcccgtgc agctgcccgg cgcctacaac     1620

gtcaacatca agctggacat cacctcccac aacgaggact acaccatcgt ggaacagtac     1680

gagcgcgccg agggccgcca ctccaccggc ggcatggacg agctgtacaa gtaa           1734


<210>  855
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  855

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
                165                 170                 175 


<210>  856
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  856
attacctgcc cccctccgat gagcgtggag cacgccgaca tctgggtcaa gagctacagc       60

ttgtatagta gggagcggta catctgtaac agcgggttca agaggaaggc cgggaccagc      120

tcactgaccg agtgcgtgtt gaacaaggcc accaacgtgg cccactggac cacccctagc      180

cttaagtgca tcagggaccc agcgctcgta caccagagac ccgcgcctcc ctctacggta      240

accacggcag gcgtaacccc ccagcccgag agcctgtccc cgagcggcaa ggagcctgca      300

gcgagcagcc cctcaagcaa caacacagcc gctaccaccg cggcaatcgt gcccggcagc      360

cagctgatgc cctcaaagag ccccagcacc ggcaccactg agataagcag ccacgagagc      420

tcacacggca ctccctcaca gaccactgcc aagaattggg agctgaccgc ctctgccagc      480

caccagcccc caggcgtgta tccccagggc cacagcgaca ccacg                      525


<210>  857
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  857

Met Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210>  858
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  858
atgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaa                   708


<210>  859
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  859

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Glu Asn Asp 
            580             


<210>  860
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  860

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Gly Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Lys Asn Asp 
            580             


<210>  861
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  861

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Val Gly Ser 
385                 390                 395                 400 


Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly Lys Asn 
                405                 410                 415     


Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr Phe Gln 
            420                 425                 430         


Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu Val Ile 
        435                 440                 445             


Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg Pro Leu 
    450                 455                 460                 


Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu Pro Pro 
465                 470                 475                 480 


Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu Lys Leu 
                485                 490                 495     


Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp Ile Val 
            500                 505                 510         


Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His Pro Gly His Leu 
        515                 520                 525             


Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp Thr Phe 
    530                 535                 540                 


Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu Tyr Pro 
545                 550                 555                 560 


Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr Lys Phe 
                565                 570                 575     


Glu Val Tyr Glu Lys Asn Asp 
            580             


<210>  862
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  862

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Tyr Pro 
145                 150                 155                 160 


Tyr Asp Val Pro Asp Tyr Ala Ile Thr Cys Pro Pro Pro Met Ser Val 
                165                 170                 175     


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
            180                 185                 190         


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
        195                 200                 205             


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
    210                 215                 220                 


Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg 
225                 230                 235                 240 


Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro 
                245                 250                 255     


Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser 
            260                 265                 270         


Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln 
        275                 280                 285             


Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser 
    290                 295                 300                 


His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp 
305                 310                 315                 320 


Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln 
                325                 330                 335     


Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu 
            340                 345                 350         


Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg 
        355                 360                 365             


Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu 
    370                 375                 380                 


Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys 
385                 390                 395                 400 


Ser His His Leu 
                


<210>  863
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  863

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
                405                 410         


<210>  864
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  864

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
                165                 170                 175     


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
            180                 185                 190         


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
        195                 200                 205             


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
    210                 215                 220                 


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
225                 230                 235                 240 


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
                245                 250                 255     


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
            260                 265                 270         


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
        275                 280                 285             


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
    290                 295                 300                 


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
305                 310                 315                 320 


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                325                 330                 335     


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
            340                 345                 350         


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
        355                 360                 365             


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
    370                 375                 380                 


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
385                 390                 395                 400 


His His Leu 
            


<210>  865
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  865

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr 
145                 150                 155                 160 


Ala Ser Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
                165                 170                 175     


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
            180                 185                 190         


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
        195                 200                 205             


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
    210                 215                 220                 


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
225                 230                 235                 240 


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
                245                 250                 255     


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
            260                 265                 270         


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
        275                 280                 285             


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
    290                 295                 300                 


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
305                 310                 315                 320 


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
                325                 330                 335     


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
            340                 345                 350         


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
        355                 360                 365             


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
    370                 375                 380                 


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
385                 390                 395                 400 


His His Leu 
            


<210>  866
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  866

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
    130                 135                 140                 


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
145                 150                 155                 160 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                165                 170                 175     


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
            180                 185                 190         


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
        195                 200                 205             


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
    210                 215                 220                 


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
                245                 250                 255     


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
            260                 265                 270         


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
        275                 280                 285             


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
    290                 295                 300                 


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
305                 310                 315                 320 


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
                325                 330                 335     


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
            340                 345                 350         


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
        355                 360                 365             


His His Leu 
    370     


<210>  867
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  867

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Asn Trp 
            20                  25                  30          


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        35                  40                  45              


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    50                  55                  60                  


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
65                  70                  75                  80  


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                85                  90                  95      


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            100                 105                 110         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        115                 120                 125             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro 
                165                 170                 175     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            180                 185                 190         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        195                 200                 205             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    210                 215                 220                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
225                 230                 235                 240 


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
                245                 250                 255     


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
            260                 265                 270         


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
        275                 280                 285             


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
    290                 295                 300                 


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
305                 310                 315                 320 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
                325                 330                 335     


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
            340                 345                 350         


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
        355                 360                 365             


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
    370                 375                 380                 


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Asn Cys Ser His His Leu 
                405         


<210>  868
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  868

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser 
385                 390                 395         


<210>  869
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  869

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Gly Ile Ser Leu 
385                 390                 395                 400 


Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn Ala Met 
                405                 410                 415     


Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn Thr Leu 
            420                 425                 430         


Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile Gly Arg 
        435                 440                 445             


Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro Gly Thr 
    450                 455                 460                 


Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile Ala Ala 
465                 470                 475                 480 


Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg Val Ile 
                485                 490                 495     


Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His Ile Asp 
            500                 505                 510         


Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro Asp Asp 
        515                 520                 525             


Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln Asn Ser 
    530                 535                 540                 


His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
545                 550                 555 


<210>  870
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  870

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Asn Trp 
            20                  25                  30          


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
        35                  40                  45              


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
    50                  55                  60                  


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
65                  70                  75                  80  


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
                85                  90                  95      


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
            100                 105                 110         


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
        115                 120                 125             


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    130                 135                 140                 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro 
                165                 170                 175     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            180                 185                 190         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        195                 200                 205             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    210                 215                 220                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
225                 230                 235                 240 


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
                245                 250                 255     


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
            260                 265                 270         


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
        275                 280                 285             


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
    290                 295                 300                 


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
305                 310                 315                 320 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
                325                 330                 335     


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
            340                 345                 350         


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
        355                 360                 365             


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
    370                 375                 380                 


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
385                 390                 395                 400 


Glu Asn Cys Ser His His Leu 
                405         


<210>  871
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  871

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu 
    130                 135                 140                 


His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg 
145                 150                 155                 160 


Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu 
                165                 170                 175     


Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr 
            180                 185                 190         


Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro 
        195                 200                 205             


Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu 
    210                 215                 220                 


Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu 
                245                 250                 255     


Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His 
            260                 265                 270         


Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu 
        275                 280                 285             


Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
    290                 295                 300                 


His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys 
305                 310                 315                 320 


Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
                325                 330                 335     


Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met Glu Ala Leu Pro 
            340                 345                 350         


Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser 
        355                 360                 365             


His His Leu 
    370     


<210>  872
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  872

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Ile 
                405                 410                 415     


Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu Asn 
            420                 425                 430         


Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg Asn 
        435                 440                 445             


Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser Ile 
    450                 455                 460                 


Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln Pro 
465                 470                 475                 480 


Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala Ile 
                485                 490                 495     


Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly Arg 
            500                 505                 510         


Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr His 
        515                 520                 525             


Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu Pro 
    530                 535                 540                 


Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala Gln 
545                 550                 555                 560 


Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
                565                 570             


<210>  873
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  873

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser 
                405                 410                 


<210>  874
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  874

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Glu Asn Asp 
        595                 600     


<210>  875
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  875

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Gly 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Phe Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210>  876
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  876

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


Arg Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Gly Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210>  877
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  877

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210>  878
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  878

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Tyr His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210>  879
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  879

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val Ile 
            20                  25                  30          


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
        35                  40                  45              


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
    50                  55                  60                  


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
                85                  90                  95      


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
            100                 105                 110         


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
        115                 120                 125             


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Leu Gln Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile 
                165                 170                 175     


Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys 
            180                 185                 190         


Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe 
        195                 200                 205             


Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys 
    210                 215                 220                 


Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg 
225                 230                 235                 240 


Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr 
                245                 250                 255     


Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys 
            260                 265                 270         


Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr 
        275                 280                 285             


Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser 
    290                 295                 300                 


Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro 
305                 310                 315                 320 


Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His 
                325                 330                 335     


Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala 
            340                 345                 350         


Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu 
        355                 360                 365             


Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val 
    370                 375                 380                 


Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser 
385                 390                 395                 400 


Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Val 
                405                 410                 415     


Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Val Gly 
            420                 425                 430         


Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg Tyr 
        435                 440                 445             


Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn Leu 
    450                 455                 460                 


Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn Arg 
465                 470                 475                 480 


Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys Glu 
                485                 490                 495     


Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala Leu 
            500                 505                 510         


Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val Trp 
        515                 520                 525             


Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro Gly 
    530                 535                 540                 


His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser Asp 
545                 550                 555                 560 


Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro Glu 
                565                 570                 575     


Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys Tyr 
            580                 585                 590         


Lys Phe Glu Val Tyr Glu Lys Asn Asp 
        595                 600     


<210>  880
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  880

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Ser Arg Met Asp Tyr 
385                 390                 395                 400 


Lys Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr 
                405                 410                 415     


Lys Asp Asp Asp Asp Lys Ser Arg Gly Ser Gly Ala Thr Asn Phe Ser 
            420                 425                 430         


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Leu Ser 
        435                 440                 445             


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
    450                 455                 460                 


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
465                 470                 475                 480 


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
                485                 490                 495     


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
            500                 505                 510         


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
        515                 520                 525             


Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
    530                 535                 540                 


Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp 
545                 550                 555                 560 


Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly 
                565                 570                 575     


Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
            580                 585                 590         


Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys 
        595                 600                 605             


Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp 
    610                 615                 620                 


Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro 
625                 630                 635                 640 


Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu 
                645                 650                 655     


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser 
            660                 665                 670         


Thr Gly Gly Met Asp Glu Leu Tyr Lys 
        675                 680     


<210>  881
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  881

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu Gly Ser Gly Ala Thr 
385                 390                 395                 400 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                405                 410                 415     


Pro Leu Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
            420                 425                 430         


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
        435                 440                 445             


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
    450                 455                 460                 


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
465                 470                 475                 480 


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
                485                 490                 495     


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
            500                 505                 510         


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
        515                 520                 525             


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
    530                 535                 540                 


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
545                 550                 555                 560 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
                565                 570                 575     


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
            580                 585                 590         


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
        595                 600                 605             


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
    610                 615                 620                 


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
625                 630                 635                 640 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                645                 650         


<210>  882
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  882

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  883
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  883

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Thr Thr Thr 
                325                 330                 335     


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            340                 345                 350         


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        355                 360                 365             


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    370                 375                 380                 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
385                 390                 395                 400 


Tyr Cys 
        


<210>  884
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  884
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagtgg tgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt ttataaggaa     1560

gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

gagaatgatt ga                                                         1752


<210>  885
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  885
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagtgg tgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt ttataaggaa     1560

gccatgaatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc aggataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggctttaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210>  886
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  886
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgagtgg tgttggttcg     1200

ctaaactgca tcgtcgctgt gtcccagaac atgggcatcg gcaagaacgg ggacctgccc     1260

tggccaccgc tcaggaatga attcagatat ttccagagaa tgaccacaac ctcttcagta     1320

gaaggtaaac agaatctggt gattatgggt aagaagacct ggttctccat tcctgagaag     1380

aatcgacctt taaagggtag aattaattta gttctcagca gagaactcaa ggaacctcca     1440

caaggagctc attttctttc cagaagtcta gatgatgcct taaaacttac tgaacaacca     1500

gaattagcaa ataaagtaga catggtctgg atagttggtg gcagttctgt ttataaggaa     1560

gccatgtatc acccaggcca tcttaaacta tttgtgacaa ggatcatgca agactttgaa     1620

agtgacacgt tttttccaga aattgatttg gagaaatata aacttctgcc agaataccca     1680

ggtgttctct ctgatgtcca ggaggagaaa ggcattaagt acaaatttga agtatatgag     1740

aagaatgatt ga                                                         1752


<210>  887
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  887
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggtg gaggcagctt gcaataccca      480

tacgatgttc cagattacgc tattacctgc ccccctccga tgagcgtgga gcacgccgac      540

atctgggtca agagctacag cttgtatagt agggagcggt acatctgtaa cagcgggttc      600

aagaggaagg ccgggaccag ctcactgacc gagtgcgtgt tgaacaaggc caccaacgtg      660

gcccactgga ccacccctag ccttaagtgc atcagggacc cagcgctcgt acaccagaga      720

cccgcgcctc cctctacggt aaccacggca ggcgtaaccc cccagcccga gagcctgtcc      780

ccgagcggca aggagcctgc agcgagcagc ccctcaagca acaacacagc cgctaccacc      840

gcggcaatcg tgcccggcag ccagctgatg ccctcaaaga gccccagcac cggcaccact      900

gagataagca gccacgagag ctcacacggc actccctcac agaccactgc caagaattgg      960

gagctgaccg cctctgccag ccaccagccc ccaggcgtgt atccccaggg ccacagcgac     1020

accacggtcg ccatcagcac atctacagtg cttttgtgcg gccttagcgc cgtgtcactg     1080

ctggcatgct acttgaaaag taggcaaact ccccctcttg ccagtgtgga aatggaggcc     1140

atggaagccc tgcccgtgac ctggggcacc agttctaggg acgaggacct tgagaactgc     1200

tcacatcatt tgtga                                                      1215


<210>  888
<211>  1239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  888
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgtga                            1239


<210>  889
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  889
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttctg gtggcgggag tggaggaggt      420

gggtccggag ggggagggag cggtggtgga ggttccggcg gggggggtag tggaggcgga      480

gggtcaggtg ggggcagcat tacctgcccc cctccgatga gcgtggagca cgccgacatc      540

tgggtcaaga gctacagctt gtatagtagg gagcggtaca tctgtaacag cgggttcaag      600

aggaaggccg ggaccagctc actgaccgag tgcgtgttga acaaggccac caacgtggcc      660

cactggacca cccctagcct taagtgcatc agggacccag cgctcgtaca ccagagaccc      720

gcgcctccct ctacggtaac cacggcaggc gtaacccccc agcccgagag cctgtccccg      780

agcggcaagg agcctgcagc gagcagcccc tcaagcaaca acacagccgc taccaccgcg      840

gcaatcgtgc ccggcagcca gctgatgccc tcaaagagcc ccagcaccgg caccactgag      900

ataagcagcc acgagagctc acacggcact ccctcacaga ccactgccaa gaattgggag      960

ctgaccgcct ctgccagcca ccagccccca ggcgtgtatc cccagggcca cagcgacacc     1020

acggtcgcca tcagcacatc tacagtgctt ttgtgcggcc ttagcgccgt gtcactgctg     1080

gcatgctact tgaaaagtag gcaaactccc cctcttgcca gtgtggaaat ggaggccatg     1140

gaagccctgc ccgtgacctg gggcaccagt tctagggacg aggaccttga gaactgctca     1200

catcatttgt ga                                                         1212


<210>  890
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  890
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttctagtg gtggcgggtc cggcggtggt      420

ggtagcgggg gtggaggctc aggtggcggt ggcagttatc cttacgatgt gcccgactat      480

gcttcaggcg gggggagtat tacctgcccc cctccgatga gcgtggagca cgccgacatc      540

tgggtcaaga gctacagctt gtatagtagg gagcggtaca tctgtaacag cgggttcaag      600

aggaaggccg ggaccagctc actgaccgag tgcgtgttga acaaggccac caacgtggcc      660

cactggacca cccctagcct taagtgcatc agggacccag cgctcgtaca ccagagaccc      720

gcgcctccct ctacggtaac cacggcaggc gtaacccccc agcccgagag cctgtccccg      780

agcggcaagg agcctgcagc gagcagcccc tcaagcaaca acacagccgc taccaccgcg      840

gcaatcgtgc ccggcagcca gctgatgccc tcaaagagcc ccagcaccgg caccactgag      900

ataagcagcc acgagagctc acacggcact ccctcacaga ccactgccaa gaattgggag      960

ctgaccgcct ctgccagcca ccagccccca ggcgtgtatc cccagggcca cagcgacacc     1020

acggtcgcca tcagcacatc tacagtgctt ttgtgcggcc ttagcgccgt gtcactgctg     1080

gcatgctact tgaaaagtag gcaaactccc cctcttgcca gtgtggaaat ggaggccatg     1140

gaagccctgc ccgtgacctg gggcaccagt tctagggacg aggaccttga gaactgctca     1200

catcatttgt ga                                                         1212


<210>  891
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  891
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttctagtg gtattacctg cccccctccg      420

atgagcgtgg agcacgccga catctgggtc aagagctaca gcttgtatag tagggagcgg      480

tacatctgta acagcgggtt caagaggaag gccgggacca gctcactgac cgagtgcgtg      540

ttgaacaagg ccaccaacgt ggcccactgg accaccccta gccttaagtg catcagggac      600

ccagcgctcg tacaccagag acccgcgcct ccctctacgg taaccacggc aggcgtaacc      660

ccccagcccg agagcctgtc cccgagcggc aaggagcctg cagcgagcag cccctcaagc      720

aacaacacag ccgctaccac cgcggcaatc gtgcccggca gccagctgat gccctcaaag      780

agccccagca ccggcaccac tgagataagc agccacgaga gctcacacgg cactccctca      840

cagaccactg ccaagaattg ggagctgacc gcctctgcca gccaccagcc cccaggcgtg      900

tatccccagg gccacagcga caccacggtc gccatcagca catctacagt gcttttgtgc      960

ggccttagcg ccgtgtcact gctggcatgc tacttgaaaa gtaggcaaac tccccctctt     1020

gccagtgtgg aaatggaggc catggaagcc ctgcccgtga cctggggcac cagttctagg     1080

gacgaggacc ttgagaactg ctcacatcat ttgtga                               1116


<210>  892
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  892
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc aactgggtga atgtaataag tgatttgaaa      120

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      180

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      240

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca      300

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa      360

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc      420

atcaacactt cttccggtgg aggtagcggt ggagggggtt ctggtggagg aggttctgga      480

ggtggaggtt ctggcggtgg gtccttgcaa atcacgtgcc ctccccccat gtccgtggaa      540

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      600

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      660

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      720

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      780

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      840

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      900

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      960

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc     1020

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     1080

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa     1140

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg     1200

gaaaactgct ctcaccacct atga                                            1224


<210>  893
<211>  1194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  893
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacgg tcgccatcag cacatctaca     1020

gtgcttttgt gcggccttag cgccgtgtca ctgctggcat gctacttgaa aagtaggcaa     1080

actccccctc ttgccagtgt ggaaatggag gccatggaag ccctgcccgt gacctggggc     1140

accagttcta gggacgagga ccttgagaac tgctcacatc atttgggatc ctga           1194


<210>  894
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  894
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaattgg       60

gtcaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac      120

gccacactgt acaccgagtc cgatgtgcac cctagctgca aagtgaccgc catgaagtgc      180

tttctgctgg aactgcaagt gatcagcctg gaaagcggcg acgccagcat ccacgatacc      240

gtggaaaatc tgatcatcct ggccaacaac agcctgagca gcaacggcaa tgtgaccgag      300

agcggctgca aagagtgcga ggaactggaa gagaagaaca tcaaagagtt cctccagagc      360

ttcgtccaca tcgtgcagat gttcatcaac accagctctg gcggaggaag cggaggcgga      420

ggatctggtg gtggtggatc tggcggcggt ggtagtggcg gaggttctct gcaaatcacc      480

tgtcctccac ctatgagcgt ggaacacgcc gacatctggg tcaagagcta cagcctgtac      540

agcagagagc ggtacatctg caacagcggc ttcaagagaa aggccggcac aagcagcctg      600

accgagtgtg tgctgaacaa ggccacaaac gtggcccact ggaccacacc tagcctgaag      660

tgcatcagag atcccgctct ggttcaccag aggcctgctc ctccatctac agtgacaaca      720

gctggcgtga cccctcagcc tgagtctctg tctccatctg gaaaagagcc tgccgccagc      780

tctcccagct ctaacaatac tgctgccacc acagccgcca tcgtgcctgg atctcagctg      840

atgcctagca agagccctag caccggcaca acagagatca gctctcacga gtctagccac      900

ggcaccccat ctcagaccac agccaagaat tgggagctga ccgcctctgc ctctcatcag      960

ccacctggtg tttaccctca aggccactct gataccaccg tggccatcag cacaagcaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gctacctgaa gtctagacag     1080

acacctcctc tggccagcgt ggaaatggaa gccatggaag ctctgcctgt gacatggggc     1140

accagcagca gagatgagga cctcgagaat tgcagccacc acctgtag                  1188


<210>  895
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  895
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaattgg       60

gtcaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac      120

gccacactgt acaccgagtc cgatgtgcac cctagctgca aagtgaccgc catgaagtgc      180

tttctgctgg aactgcaagt gatcagcctg gaaagcggcg acgccagcat ccacgatacc      240

gtggaaaatc tgatcatcct ggccaacaac agcctgagca gcaacggcaa tgtgaccgag      300

agcggctgca aagagtgcga ggaactggaa gagaagaaca tcaaagagtt cctccagagc      360

ttcgtccaca tcgtgcagat gttcatcaac accagctctg gcggaggaag cggaggcgga      420

ggatctggtg gtggtggatc tggcggcggt ggtagtggcg gaggttctct gcaaatcacc      480

tgtcctccac ctatgagcgt ggaacacgcc gacatctggg tcaagagcta cagcctgtac      540

agcagagagc ggtacatctg caacagcggc ttcaagagaa aggccggcac aagcagcctg      600

accgagtgtg tgctgaacaa ggccacaaac gtggcccact ggaccacacc tagcctgaag      660

tgcatcagag atcccgctct ggttcaccag aggcctgctc ctccatctac agtgacaaca      720

gctggcgtga cccctcagcc tgagtctctg tctccatctg gaaaagagcc tgccgccagc      780

tctcccagct ctaacaatac tgctgccacc acagccgcca tcgtgcctgg atctcagctg      840

atgcctagca agagccctag caccggcaca acagagatca gctctcacga gtctagccac      900

ggcaccccat ctcagaccac agccaagaat tgggagctga ccgcctctgc ctctcatcag      960

ccacctggtg tttaccctca aggccactct gataccaccg tggccatcag cacaagcaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gctacctgaa gtctagacag     1080

acacctcctc tggccagcgt ggaaatggaa gccatggaag ctctgcctgt gacatggggc     1140

accagcagca gagatgagga cctcgagaat tgcagccacc acctgtag                  1188


<210>  896
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  896
atggactgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaattgg       60

gtcaacgtga tcagcgacct gaagaagatc gaggacctga tccagagcat gcacatcgac      120

gccacactgt acaccgagtc cgatgtgcac cctagctgca aagtgaccgc catgaagtgc      180

tttctgctgg aactgcaagt gatcagcctg gaaagcggcg acgccagcat ccacgatacc      240

gtggaaaatc tgatcatcct ggccaacaac agcctgagca gcaacggcaa tgtgaccgag      300

agcggctgca aagagtgcga ggaactggaa gagaagaaca tcaaagagtt cctccagagc      360

ttcgtccaca tcgtgcagat gttcatcaac accagctctg gcggaggaag cggaggcgga      420

ggatctggtg gtggtggatc tggcggcggt ggtagtggcg gaggttctct gcaaatcacc      480

tgtcctccac ctatgagcgt ggaacacgcc gacatctggg tcaagagcta cagcctgtac      540

agcagagagc ggtacatctg caacagcggc ttcaagagaa aggccggcac aagcagcctg      600

accgagtgtg tgctgaacaa ggccacaaac gtggcccact ggaccacacc tagcctgaag      660

tgcatcagag atcccgctct ggttcaccag aggcctgctc ctccatctac agtgacaaca      720

gctggcgtga cccctcagcc tgagtctctg tctccatctg gaaaagagcc tgccgccagc      780

tctcccagct ctaacaatac tgctgccacc acagccgcca tcgtgcctgg atctcagctg      840

atgcctagca agagccctag caccggcaca acagagatca gctctcacga gtctagccac      900

ggcaccccat ctcagaccac agccaagaat tgggagctga ccgcctctgc ctctcatcag      960

ccacctggtg tttaccctca aggccactct gataccaccg tggccatcag cacaagcaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gctacctgaa gtctagacag     1080

acacctcctc tggccagcgt ggaaatggaa gccatggaag ctctgcctgt gacatggggc     1140

accagcagca gagatgagga cctcgagaat tgcagccacc acctgagcgg catctctctg     1200

attgcggcgc tggcagttga ctacgttatt ggcatggaaa acgcgatgcc atggaacctc     1260

ccggctgacc tggcgtggtt caaacgtaac accctgaaca aacctgtgat catgggtcgt     1320

cacacctggg aatctattgg ccgtcctctc ccgggtcgta aaaacatcat tctgtcttct     1380

cagccaggca ccgacgaccg tgttacctgg gttaaaagcg ttgacgaagc gattgctgcg     1440

tgcggtgatg ttcctgaaat tatggtgatc ggcggtggcc gtgttatcga acagttcctg     1500

ccgaaagcgc agaaactgta cctgacccac atcgacgcgg aagttgaagg tgacacccac     1560

ttcccggact acgaaccgga tgattgggag agcgtattct ccgaattcca tgatgcggat     1620

gcgcaaaact ctcattctta ctgttttgaa atcctggaac gtcgttag                  1668


<210>  897
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  897
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc aactgggtga atgtaataag tgatttgaaa      120

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      180

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      240

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca      300

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa      360

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc      420

atcaacactt cttccggtgg aggtagcggt ggagggggtt ctggtggagg aggttctgga      480

ggtggaggtt ctggcggtgg gtccttgcaa atcacgtgcc ctccccccat gtccgtggaa      540

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      600

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      660

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      720

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      780

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      840

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      900

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      960

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc     1020

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     1080

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa     1140

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg     1200

gaaaactgct ctcaccacct atga                                            1224


<210>  898
<211>  1116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  898
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttctggat ccattacctg cccccctccg      420

atgagcgtgg agcacgccga catctgggtc aagagctaca gcttgtatag tagggagcgg      480

tacatctgta acagcgggtt caagaggaag gccgggacca gctcactgac cgagtgcgtg      540

ttgaacaagg ccaccaacgt ggcccactgg accaccccta gccttaagtg catcagggac      600

ccagcgctcg tacaccagag acccgcgcct ccctctacgg taaccacggc aggcgtaacc      660

ccccagcccg agagcctgtc cccgagcggc aaggagcctg cagcgagcag cccctcaagc      720

aacaacacag ccgctaccac cgcggcaatc gtgcccggca gccagctgat gccctcaaag      780

agccccagca ccggcaccac tgagataagc agccacgaga gctcacacgg cactccctca      840

cagaccactg ccaagaattg ggagctgacc gcctctgcca gccaccagcc cccaggcgtg      900

tatccccagg gccacagcga caccacggtc gccatcagca catctacagt gcttttgtgc      960

ggccttagcg ccgtgtcact gctggcatgc tacttgaaaa gtaggcaaac tccccctctt     1020

gccagtgtgg aaatggaggc catggaagcc ctgcccgtga cctggggcac cagttctagg     1080

gacgaggacc ttgagaactg ctcacatcat ttgtga                               1116


<210>  899
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  899
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc aactgggtga atgtaataag tgatttgaaa      120

aaaattgaag atcttattca atctatgcat attgatgcta ctttatatac ggaaagtgat      180

gttcacccca gttgcaaagt aacagcaatg aagtgctttc tcttggagtt acaagttatt      240

tcacttgagt ccggagatgc aagtattcat gatacagtag aaaatctgat catcctagca      300

aacaacagtt tgtcttctaa tgggaatgta acagaatctg gatgcaaaga atgtgaggaa      360

ctggaggaaa aaaatattaa agaatttttg cagagttttg tacatattgt ccaaatgttc      420

atcaacactt cttccggggg gggtagcggg ggagggggtt ccggcggggg agggtctgga      480

gggggaggtt ccggcggggg gtccttgcaa atcacgtgcc ctccccccat gtccgtggaa      540

cacgcagaca tctgggtcaa gagctacagc ttgtactcca gggagcggta catttgtaac      600

tctggtttca agcgtaaagc cggcacgtcc agcctgacgg agtgcgtgtt gaacaaggcc      660

acgaatgtcg cccactggac aacccccagt ctcaaatgca ttagagaccc tgccctggtt      720

caccaaaggc cagcgccacc ctccacagta acgacggcag gggtgacccc acagccagag      780

agcctctccc cttctggaaa agagcccgca gcttcatctc ccagctcaaa caacacagcg      840

gccacaacag cagctattgt cccgggctcc cagctgatgc cttcaaaatc accttccaca      900

ggaaccacag agataagcag tcatgagtcc tcccacggca ccccctctca gacaacagcc      960

aagaactggg aactcacagc atccgcctcc caccagccgc caggtgtgta tccacagggc     1020

cacagcgaca ccactgtggc tatctccacg tccactgtcc tgctgtgtgg gctgagcgct     1080

gtgtctctcc tggcatgcta cctcaagtca aggcaaactc ccccgctggc cagcgttgaa     1140

atggaagcca tggaggctct gccggtgact tgggggacca gcagcagaga tgaagacttg     1200

gaaaactgct ctcaccacct atga                                            1224


<210>  900
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  900
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggaatctc tctgattgcg     1260

gcgctggcag ttgactacgt tattggcatg gaaaacgcga tgccatggaa cctcccggct     1320

gacctggcgt ggttcaaacg taacaccctg aacaaacctg tgatcatggg tcgtcacacc     1380

tgggaatcta ttggccgtcc tctcccgggt cgtaaaaaca tcattctgtc ttctcagcca     1440

ggcaccgacg accgtgttac ctgggttaaa agcgttgacg aagcgattgc tgcgtgcggt     1500

gatgttcctg aaattatggt gatcggcggt ggccgtgtta tcgaacagtt cctgccgaaa     1560

gcgcagaaac tgtacctgac ccacatcgac gcggaagttg aaggtgacac ccacttcccg     1620

gactacgaac cggatgattg ggagagcgta ttctccgaat tccatgatgc ggatgcgcaa     1680

aactctcatt cttactgttt tgaaatcctg gaacgtcgtt ga                        1722


<210>  901
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  901
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat cctga                     1245


<210>  902
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  902
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgaggagaat     1800

gattga                                                                1806


<210>  903
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  903
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccaggata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcttt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210>  904
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  904
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gcagacttaa actatttgtg acaaggatca tgcaagactt tggaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210>  905
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  905
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210>  906
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  906
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa ggaagccatg     1620

tatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210>  907
<211>  1806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  907
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcgactac       60

aaagacgatg acgacaagaa ctgggtgaac gtgatctccg acctgaaaaa gatcgaggat      120

ttgatccaga gcatgcacat tgacgccacc ctgtataccg agtccgacgt gcacccgagt      180

tgcaaggtga ctgccatgaa gtgcttcctg ctggagctgc aagtgatcag cctggagagc      240

ggcgacgcca gcatccacga caccgtggaa aaccttatca ttctggccaa caatagcctg      300

agcagcaacg gcaacgtgac cgaaagcgga tgtaaggaat gcgaggaact ggaagagaag      360

aatatcaaag aattcctgca aagcttcgtg cacatcgtgc agatgttcat caacacttct      420

tcaggtggcg gtagtggtgg gggaggatct ggaggcggag gaagcggggg tggaggttca      480

ggtggaggca gcttgcaata cccatacgat gttccagatt acgctattac ctgcccccct      540

ccgatgagcg tggagcacgc cgacatctgg gtcaagagct acagcttgta tagtagggag      600

cggtacatct gtaacagcgg gttcaagagg aaggccggga ccagctcact gaccgagtgc      660

gtgttgaaca aggccaccaa cgtggcccac tggaccaccc ctagccttaa gtgcatcagg      720

gacccagcgc tcgtacacca gagacccgcg cctccctcta cggtaaccac ggcaggcgta      780

accccccagc ccgagagcct gtccccgagc ggcaaggagc ctgcagcgag cagcccctca      840

agcaacaaca cagccgctac caccgcggca atcgtgcccg gcagccagct gatgccctca      900

aagagcccca gcaccggcac cactgagata agcagccacg agagctcaca cggcactccc      960

tcacagacca ctgccaagaa ttgggagctg accgcctctg ccagccacca gcccccaggc     1020

gtgtatcccc agggccacag cgacaccacg gtcgccatca gcacatctac agtgcttttg     1080

tgcggcctta gcgccgtgtc actgctggca tgctacttga aaagtaggca aactccccct     1140

cttgccagtg tggaaatgga ggccatggaa gccctgcccg tgacctgggg caccagttct     1200

agggacgagg accttgagaa ctgctcacat catttgggat ccggtgttgg ttcgctaaac     1260

tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct gccctggcca     1320

ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc agtagaaggt     1380

aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga gaagaatcga     1440

cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc tccacaagga     1500

gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca accagaatta     1560

gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgttattaa ggaagccatg     1620

aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt tgaaagtgac     1680

acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata cccaggtgtt     1740

ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata tgagaagaat     1800

gattga                                                                1806


<210>  908
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  908
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaactgg       60

gtgaatgtga tcagcgacct gaagaagatc gaggatctga tccagagcat gcacattgat      120

gccaccctgt acacagaatc tgatgtgcac cctagctgta aagtgaccgc catgaagtgt      180

tttctgctgg agctgcaggt gatttctctg gaaagcggag atgcctctat ccacgacaca      240

gtggagaatc tgatcatcct ggccaacaat agcctgagca gcaatggcaa tgtgacagag      300

tctggctgta aggagtgtga ggagctggag gagaagaaca tcaaggagtt tctgcagagc      360

tttgtgcaca tcgtgcagat gttcatcaat acaagctctg gcggaggatc tggaggaggc      420

ggatctggag gaggaggcag tggaggcgga ggatctggcg gaggatctct gcagattaca      480

tgccctcctc caatgtctgt ggagcacgcc gatatttggg tgaagtccta cagcctgtac      540

agcagagaga gatacatctg caacagcggc tttaagagaa aggccggcac ctcttctctg      600

acagagtgcg tgctgaataa ggccacaaat gtggcccact ggacaacacc tagcctgaag      660

tgcattagag atcctgccct ggtccaccag aggcctgccc ctccatctac agtgacaaca      720

gccggagtga cacctcagcc tgaatctctg agcccttctg gaaaagaacc tgccgccagc      780

tctcctagct ctaataatac cgccgccaca acagccgcca ttgtgcctgg atctcagctg      840

atgcctagca agtctcctag cacaggcaca acagagatca gcagccacga atcttctcac      900

ggaacacctt ctcagaccac cgccaagaat tgggagctga cagcctctgc ctctcaccag      960

cctccaggag tgtatcctca gggccactct gatacaacag tggccatcag cacatctaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gttacctgaa gtctagacag     1080

acacctcctc tggcctctgt ggagatggag gccatggaag ccctgcctgt gacatgggga     1140

acaagcagca gagatgagga cctggagaat tgttctcacc acctgtcgcg aatggactac     1200

aaggacgatg acgacaagga ttataaagat gatgatgata aagattataa agacgacgat     1260

gataagtcgc gaggatccgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     1320

gaggagaacc ctggaccttt gagcaagggc gaggaggaca acatggccat catcaaggag     1380

ttcatgcgct tcaaggtgca catggagggc tccgtgaacg gccacgagtt cgagatcgag     1440

ggcgagggcg agggccgccc ctacgagggc acccagaccg ccaagctgaa ggtgaccaag     1500

ggcggccccc tgcccttcgc ctgggacatc ctgtcccctc agttcatgta cggctccaag     1560

gcctacgtga agcaccccgc cgacatcccc gactacttga agctgtcctt ccccgagggc     1620

ttcaagtggg agcgcgtgat gaacttcgag gacggcggcg tggtgaccgt gacccaggac     1680

tcctccctgc aggacggcga gttcatctac aaggtgaagc tgcgcggcac caacttcccc     1740

tccgacggcc ccgtaatgca gaagaagacc atgggctggg aggcctcctc cgagcggatg     1800

taccccgagg acggcgccct gaagggcgag atcaagcaga ggctgaagct gaaggacggc     1860

ggccactacg acgccgaggt caagaccacc tacaaggcca agaagcccgt gcagctgccc     1920

ggcgcctaca acgtcaacat caagctggac atcacctccc acaacgagga ctacaccatc     1980

gtggaacagt acgagcgcgc cgagggccgc cactccaccg gcggcatgga cgagctgtac     2040

aagtaa                                                                2046


<210>  909
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  909
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaactgg       60

gtgaatgtga tcagcgacct gaagaagatc gaggatctga tccagagcat gcacattgat      120

gccaccctgt acacagaatc tgatgtgcac cctagctgta aagtgaccgc catgaagtgt      180

tttctgctgg agctgcaggt gatttctctg gaaagcggag atgcctctat ccacgacaca      240

gtggagaatc tgatcatcct ggccaacaat agcctgagca gcaatggcaa tgtgacagag      300

tctggctgta aggagtgtga ggagctggag gagaagaaca tcaaggagtt tctgcagagc      360

tttgtgcaca tcgtgcagat gttcatcaat acaagctctg gcggaggatc tggaggaggc      420

ggatctggag gaggaggcag tggaggcgga ggatctggcg gaggatctct gcagattaca      480

tgccctcctc caatgtctgt ggagcacgcc gatatttggg tgaagtccta cagcctgtac      540

agcagagaga gatacatctg caacagcggc tttaagagaa aggccggcac ctcttctctg      600

acagagtgcg tgctgaataa ggccacaaat gtggcccact ggacaacacc tagcctgaag      660

tgcattagag atcctgccct ggtccaccag aggcctgccc ctccatctac agtgacaaca      720

gccggagtga cacctcagcc tgaatctctg agcccttctg gaaaagaacc tgccgccagc      780

tctcctagct ctaataatac cgccgccaca acagccgcca ttgtgcctgg atctcagctg      840

atgcctagca agtctcctag cacaggcaca acagagatca gcagccacga atcttctcac      900

ggaacacctt ctcagaccac cgccaagaat tgggagctga cagcctctgc ctctcaccag      960

cctccaggag tgtatcctca gggccactct gatacaacag tggccatcag cacatctaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gttacctgaa gtctagacag     1080

acacctcctc tggcctctgt ggagatggag gccatggaag ccctgcctgt gacatgggga     1140

acaagcagca gagatgagga cctggagaat tgttctcacc acctgggatc cggagctact     1200

aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc tttgagcaag     1260

ggcgaggagg acaacatggc catcatcaag gagttcatgc gcttcaaggt gcacatggag     1320

ggctccgtga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag     1380

ggcacccaga ccgccaagct gaaggtgacc aagggcggcc ccctgccctt cgcctgggac     1440

atcctgtccc ctcagttcat gtacggctcc aaggcctacg tgaagcaccc cgccgacatc     1500

cccgactact tgaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc     1560

gaggacggcg gcgtggtgac cgtgacccag gactcctccc tgcaggacgg cgagttcatc     1620

tacaaggtga agctgcgcgg caccaacttc ccctccgacg gccccgtaat gcagaagaag     1680

accatgggct gggaggcctc ctccgagcgg atgtaccccg aggacggcgc cctgaagggc     1740

gagatcaagc agaggctgaa gctgaaggac ggcggccact acgacgccga ggtcaagacc     1800

acctacaagg ccaagaagcc cgtgcagctg cccggcgcct acaacgtcaa catcaagctg     1860

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgagcg cgccgagggc     1920

cgccactcca ccggcggcat ggacgagctg tacaagtaa                            1959


<210>  910
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  910
atggccccgc ggcgggcgcg cggctgccgg accctcggtc tcccggcgct gctactgctg       60

ctgctgctcc ggccgccggc gacgcggggc attacctgcc cccctccgat gagcgtggag      120

cacgccgaca tctgggtcaa gagctacagc ttgtatagta gggagcggta catctgtaac      180

agcgggttca agaggaaggc cgggaccagc tcactgaccg agtgcgtgtt gaacaaggcc      240

accaacgtgg cccactggac cacccctagc cttaagtgca tcagggaccc agcgctcgta      300

caccagagac ccgcgcctcc ctctacggta accacggcag gcgtaacccc ccagcccgag      360

agcctgtccc cgagcggcaa ggagcctgca gcgagcagcc cctcaagcaa caacacagcc      420

gctaccaccg cggcaatcgt gcccggcagc cagctgatgc cctcaaagag ccccagcacc      480

ggcaccactg agataagcag ccacgagagc tcacacggca ctccctcaca gaccactgcc      540

aagaattggg agctgaccgc ctctgccagc caccagcccc caggcgtgta tccccagggc      600

cacagcgaca ccacggtcgc catcagcaca tctacagtgc ttttgtgcgg ccttagcgcc      660

gtgtcactgc tggcatgcta cttgaaaagt aggcaaactc cccctcttgc cagtgtggaa      720

atggaggcca tggaagccct gcccgtgacc tggggcacca gttctaggga cgaggacctt      780

gagaactgct cacatcattt gtga                                             804


<210>  911
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  911
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaacgtga tctccgacct gaaaaagatc gaggatttga tccagagcat gcacattgac      120

gccaccctgt ataccgagtc cgacgtgcac ccgagttgca aggtgactgc catgaagtgc      180

ttcctgctgg agctgcaagt gatcagcctg gagagcggcg acgccagcat ccacgacacc      240

gtggaaaacc ttatcattct ggccaacaat agcctgagca gcaacggcaa cgtgaccgaa      300

agcggatgta aggaatgcga ggaactggaa gagaagaata tcaaagaatt cctgcaaagc      360

ttcgtgcaca tcgtgcagat gttcatcaac acttcttcag gtggcggtag tggtggggga      420

ggatctggag gcggaggaag cgggggtgga ggttcaggag gagggagctt gcaaattacc      480

tgcccccctc cgatgagcgt ggagcacgcc gacatctggg tcaagagcta cagcttgtat      540

agtagggagc ggtacatctg taacagcggg ttcaagagga aggccgggac cagctcactg      600

accgagtgcg tgttgaacaa ggccaccaac gtggcccact ggaccacccc tagccttaag      660

tgcatcaggg acccagcgct cgtacaccag agacccgcgc ctccctctac ggtaaccacg      720

gcaggcgtaa ccccccagcc cgagagcctg tccccgagcg gcaaggagcc tgcagcgagc      780

agcccctcaa gcaacaacac agccgctacc accgcggcaa tcgtgcccgg cagccagctg      840

atgccctcaa agagccccag caccggcacc actgagataa gcagccacga gagctcacac      900

ggcactccct cacagaccac tgccaagaat tgggagctga ccgcctctgc cagccaccag      960

cccccaggcg tgtatcccca gggccacagc gacaccacga ccacaacccc agcacctcgc     1020

ccaccaacac cagcaccaac catcgcatcc cagccactgt ctctgaggcc cgaggcatgt     1080

aggcctgcag caggaggcgc cgtgcacacc aggggcctgg actttgcctg cgatatctat     1140

atctgggcac cactggcagg aacatgtggc gtgctgctgc tgtccctggt catcaccctg     1200

tattgctga                                                             1209


<210>  912
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  912

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Val Gly Ser Leu Asn Cys Ile Val Ala Val 
    130                 135                 140                 


Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro 
145                 150                 155                 160 


Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser 
                165                 170                 175     


Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe 
            180                 185                 190         


Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val 
        195                 200                 205             


Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser 
    210                 215                 220                 


Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala 
225                 230                 235                 240 


Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys 
                245                 250                 255     


Glu Ala Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile 
            260                 265                 270         


Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu 
        275                 280                 285             


Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln 
    290                 295                 300                 


Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
305                 310                 315                 320 


<210>  913
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  913

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser Val Gly Ser Leu Asn Cys Ile Val Ala Val 
    130                 135                 140                 


Ser Gln Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro 
145                 150                 155                 160 


Leu Arg Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser 
                165                 170                 175     


Val Glu Gly Lys Gln Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe 
            180                 185                 190         


Ser Ile Pro Glu Lys Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val 
        195                 200                 205             


Leu Ser Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser 
    210                 215                 220                 


Arg Ser Leu Asp Asp Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala 
225                 230                 235                 240 


Asn Lys Val Asp Met Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys 
                245                 250                 255     


Glu Ala Met Asn His Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile 
            260                 265                 270         


Met Gln Asp Phe Glu Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu 
        275                 280                 285             


Lys Tyr Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln 
    290                 295                 300                 


Glu Glu Lys Gly Ile Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
305                 310                 315                 320 


<210>  914
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  914

Met Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210>  915
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  915

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser 
    130                 


<210>  916
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  916

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Gly Ser 
    130                 


<210>  917
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  917

Met Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
1               5                   10                  15      


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
            20                  25                  30          


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
        35                  40                  45              


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
    50                  55                  60                  


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
65                  70                  75                  80  


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
                85                  90                  95      


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
            100                 105                 110         


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
        115                 120                 125             


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
    130                 135                 140                 


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
145                 150                 155                 160 


Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His 
                165                 170                 175     


Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln 
            180                 185                 190         


Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His 
        195                 200                 205             


Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg 
    210                 215                 220                 


His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210>  918
<211>  2291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  918
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggtt ccgttggttc gctaaactgc      420

atcgtcgctg tgtcccagaa catgggcatc ggcaagaacg gggacctgcc ctggccaccg      480

ctcaggaatg aattcagata tttccagaga atgaccacaa cctcttcagt agaaggtaaa      540

cagaatctgg tgattatggg taagaagacc tggttctcca ttcctgagaa gaatcgacct      600

ttaaagggta gaattaattt agttctcagc agagaactca aggaacctcc acaaggagct      660

cattttcttt ccagaagtct agatgatgcc ttaaaactta ctgaacaacc agaattagca      720

aataaagtag acatggtctg gatagttggt ggcagttctg ttattaagga agccatgaat      780

cacccaggcc atcttaaact atttgtgaca aggatcatgc aagactttga aagtgacacg      840

ttttttccag aaattgattt ggagaaatat aaacttctgc cagaataccc aggtgttctc      900

tctgatgtcc aggaggagaa aggcattaag tacaaatttg aagtatatga gaagaatgat      960

tgatctagat aatacgactc actagagatc ccgcccctct ccctcccccc cccctaacgt     1020

tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac     1080

catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag     1140

cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa     1200

ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag     1260

gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga     1320

tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag     1380

agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc     1440

ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag     1500

gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt gaaaaacacg     1560

atgataatat ggccacaacc atgatgagca agggcgagga ggataacatg gccatcatca     1620

aggagttcat gcgcttcaag gtgcacatgg agggctccgt gaacggccac gagttcgaga     1680

tcgagggcga gggcgagggc cgcccctacg agggcaccca gaccgccaag ctgaaggtga     1740

ccaagggtgg ccccctgccc ttcgcctggg acatcctgtc ccctcagttc atgtacggct     1800

ccaaggccta cgtgaagcac cccgccgaca tccccgacta cttgaagctg tccttccccg     1860

agggcttcaa gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc     1920

aggactcctc cctgcaggac ggcgagttca tctacaaggt gaagctgcgc ggcaccaact     1980

tcccctccga cggccccgta atgcagaaga agaccatggg ctgggaggcc tcctccgagc     2040

ggatgtaccc cgaggacggc gccctgaagg gcgagatcaa gcagaggctg aagctgaagg     2100

acggcggcca ctacgacgct gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc     2160

tgcccggcgc ctacaacgtc aacatcaagt tggacatcac ctcccacaac gaggactaca     2220

ccatcgtgga acagtacgaa cgcgccgagg gccgccactc caccggcggc atggacgagc     2280

tgtacaagta a                                                          2291


<210>  919
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  919
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggtt ccgttggttc gctaaactgc      420

atcgtcgctg tgtcccagaa catgggcatc ggcaagaacg gggacctgcc ctggccaccg      480

ctcaggaatg aattcagata tttccagaga atgaccacaa cctcttcagt agaaggtaaa      540

cagaatctgg tgattatggg taagaagacc tggttctcca ttcctgagaa gaatcgacct      600

ttaaagggta gaattaattt agttctcagc agagaactca aggaacctcc acaaggagct      660

cattttcttt ccagaagtct agatgatgcc ttaaaactta ctgaacaacc agaattagca      720

aataaagtag acatggtctg gatagttggt ggcagttctg ttattaagga agccatgaat      780

cacccaggcc atcttaaact atttgtgaca aggatcatgc aagactttga aagtgacacg      840

ttttttccag aaattgattt ggagaaatat aaacttctgc cagaataccc aggtgttctc      900

tctgatgtcc aggaggagaa aggcattaag tacaaatttg aagtatatga gaagaatgat      960

tga                                                                    963


<210>  920
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  920
atgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaa                   708


<210>  921
<211>  1735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  921
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggat cctgaaatct agataatacg      420

actcactaga gatcccgccc ctctccctcc ccccccccta acgttactgg ccgaagccgc      480

ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt gccgtctttt      540

ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc taggggtctt      600

tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg      660

gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg gaacccccca      720

cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg      780

gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa atggctctcc      840

tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg tatgggatct      900

gatctggggc ctcggtgcac atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta      960

ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata atatggccac     1020

aaccatgatg agcaagggcg aggaggataa catggccatc atcaaggagt tcatgcgctt     1080

caaggtgcac atggagggct ccgtgaacgg ccacgagttc gagatcgagg gcgagggcga     1140

gggccgcccc tacgagggca cccagaccgc caagctgaag gtgaccaagg gtggccccct     1200

gcccttcgcc tgggacatcc tgtcccctca gttcatgtac ggctccaagg cctacgtgaa     1260

gcaccccgcc gacatccccg actacttgaa gctgtccttc cccgagggct tcaagtggga     1320

gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg acccaggact cctccctgca     1380

ggacggcgag ttcatctaca aggtgaagct gcgcggcacc aacttcccct ccgacggccc     1440

cgtaatgcag aagaagacca tgggctggga ggcctcctcc gagcggatgt accccgagga     1500

cggcgccctg aagggcgaga tcaagcagag gctgaagctg aaggacggcg gccactacga     1560

cgctgaggtc aagaccacct acaaggccaa gaagcccgtg cagctgcccg gcgcctacaa     1620

cgtcaacatc aagttggaca tcacctccca caacgaggac tacaccatcg tggaacagta     1680

cgaacgcgcc gagggccgcc actccaccgg cggcatggac gagctgtaca agtaa          1735


<210>  922
<211>  405
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  922
atggactgga catggatact cttcctggta gcagccgcca cacgagtgca cagcaactgg       60

gtgaatgtaa taagtgattt gaaaaaaatt gaagatctta ttcaatctat gcatattgat      120

gctactttat atacggaaag tgatgttcac cccagttgca aagtaacagc aatgaagtgc      180

tttctcttgg agttacaagt tatttcactt gagtccggag atgcaagtat tcatgataca      240

gtagaaaatc tgatcatcct agcaaacaac agtttgtctt ctaatgggaa tgtaacagaa      300

tctggatgca aagaatgtga ggaactggag gaaaaaaata ttaaagaatt tttgcagagt      360

tttgtacata ttgtccaaat gttcatcaac acttctggat cctga                      405


<210>  923
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  923
atgagcaagg gcgaggagga taacatggcc atcatcaagg agttcatgcg cttcaaggtg       60

cacatggagg gctccgtgaa cggccacgag ttcgagatcg agggcgaggg cgagggccgc      120

ccctacgagg gcacccagac cgccaagctg aaggtgacca agggtggccc cctgcccttc      180

gcctgggaca tcctgtcccc tcagttcatg tacggctcca aggcctacgt gaagcacccc      240

gccgacatcc ccgactactt gaagctgtcc ttccccgagg gcttcaagtg ggagcgcgtg      300

atgaacttcg aggacggcgg cgtggtgacc gtgacccagg actcctccct gcaggacggc      360

gagttcatct acaaggtgaa gctgcgcggc accaacttcc cctccgacgg ccccgtaatg      420

cagaagaaga ccatgggctg ggaggcctcc tccgagcgga tgtaccccga ggacggcgcc      480

ctgaagggcg agatcaagca gaggctgaag ctgaaggacg gcggccacta cgacgctgag      540

gtcaagacca cctacaaggc caagaagccc gtgcagctgc ccggcgccta caacgtcaac      600

atcaagttgg acatcacctc ccacaacgag gactacacca tcgtggaaca gtacgaacgc      660

gccgagggcc gccactccac cggcggcatg gacgagctgt acaagtaa                   708


<210>  924

<400>  924
000

<210>  925

<400>  925
000

<210>  926

<400>  926
000

<210>  927

<400>  927
000

<210>  928

<400>  928
000

<210>  929

<400>  929
000

<210>  930

<400>  930
000

<210>  931

<400>  931
000

<210>  932

<400>  932
000

<210>  933

<400>  933
000

<210>  934

<400>  934
000

<210>  935

<400>  935
000

<210>  936

<400>  936
000

<210>  937

<400>  937
000

<210>  938

<400>  938
000

<210>  939

<400>  939
000

<210>  940

<400>  940
000

<210>  941

<400>  941
000

<210>  942

<400>  942
000

<210>  943

<400>  943
000

<210>  944

<400>  944
000

<210>  945

<400>  945
000

<210>  946

<400>  946
000

<210>  947

<400>  947
000

<210>  948

<400>  948
000

<210>  949

<400>  949
000

<210>  950

<400>  950
000

<210>  951

<400>  951
000

<210>  952

<400>  952
000

<210>  953

<400>  953
000

<210>  954

<400>  954
000

<210>  955

<400>  955
000

<210>  956

<400>  956
000

<210>  957

<400>  957
000

<210>  958

<400>  958
000

<210>  959

<400>  959
000

<210>  960

<400>  960
000

<210>  961

<400>  961
000

<210>  962

<400>  962
000

<210>  963

<400>  963
000

<210>  964

<400>  964
000

<210>  965

<400>  965
000

<210>  966

<400>  966
000

<210>  967

<400>  967
000

<210>  968

<400>  968
000

<210>  969

<400>  969
000

<210>  970

<400>  970
000

<210>  971

<400>  971
000

<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000

<400>  1000
000

<210>  1001

<400>  1001
000

<210>  1002

<400>  1002
000

<210>  1003

<400>  1003
000

<210>  1004

<400>  1004
000

<210>  1005

<400>  1005
000

<210>  1006

<400>  1006
000

<210>  1007

<400>  1007
000

<210>  1008

<400>  1008
000

<210>  1009

<400>  1009
000

<210>  1010

<400>  1010
000

<210>  1011

<400>  1011
000

<210>  1012

<400>  1012
000

<210>  1013

<400>  1013
000

<210>  1014

<400>  1014
000

<210>  1015

<400>  1015
000

<210>  1016

<400>  1016
000

<210>  1017

<400>  1017
000

<210>  1018

<400>  1018
000

<210>  1019

<400>  1019
000

<210>  1020

<400>  1020
000

<210>  1021

<400>  1021
000

<210>  1022

<400>  1022
000

<210>  1023

<400>  1023
000

<210>  1024

<400>  1024
000

<210>  1025

<400>  1025
000

<210>  1026

<400>  1026
000

<210>  1027

<400>  1027
000

<210>  1028

<400>  1028
000

<210>  1029

<400>  1029
000

<210>  1030
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1030

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  1031
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1031

Gly Gly Gly Gly 
1               


<210>  1032
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1032

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  1033
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Any amino acid

<400>  1033

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  1034
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  1034

Gly Ala His Ala Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
1               5                   10                  15      


Ala Pro Gly Gln Thr Ala Lys Ile Thr Cys Gly Gly Asn Asn Ile Gly 
            20                  25                  30          


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
        35                  40                  45              


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
    50                  55                  60                  


Phe Ser Gly Ser Asn Ser Gly Asn Ala Ala Thr Leu Thr Ile Ser Arg 
65                  70                  75                  80  


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
                85                  90                  95      


Ser Ser Gly Leu Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Ser 
            100                 105                 110         


Gly Gly Ser Thr Ile Thr Ser Tyr Asn Val Tyr Asp Thr Lys Leu Ser 
        115                 120                 125             


Ser Ser Gly Thr Glu Val Gln Leu Leu Glu Ser Gly Ala Glu Val Lys 
    130                 135                 140                 


Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser 
145                 150                 155                 160 


Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr 
            180                 185                 190         


Ser Pro Ser Ser Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile 
        195                 200                 205             


Ser Thr Ala Tyr Leu Arg Trp Ser Gly Leu Lys Ala Ser Asp Thr Ala 
    210                 215                 220                 


Met Tyr Tyr Cys Ala Arg Val Ser Ser Asp Ser Gly Ala Phe Asp Ile 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Gly Lys Pro 
                245                 250                 255     


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His His His 
            260                 265                 270         


His 
    


<210>  1035
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  1035

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Ser Gly Ala His Ala Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Val Ala Pro Gly Lys Thr Ala Thr Ile Pro Cys Gly Gly Asn Asn 
        35                  40                  45              


Ile Glu Ser Lys Ser Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala 
    50                  55                  60                  


Pro Val Leu Val Ile Tyr Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Val Glu Ala Gly Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp 
            100                 105                 110         


Asp Ser His Ser Asp His Glu Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Ser Gly Gly Ser Thr Ile Thr Ser Tyr Asn Val Tyr Tyr Thr 
    130                 135                 140                 


Lys Leu Ser Ser Ser Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Glu Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr 
        195                 200                 205             


Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu His Glu Trp Glu Ala Gly 
                245                 250                 255     


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
            260                 265                 270         


Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His 
        275                 280                 285             


His His His His His 
    290             


<210>  1036
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment


<220>
<221>  MOD_RES
<222>  (236)..(236)
<223>  Any amino acid

<220>
<221>  MOD_RES
<222>  (245)..(245)
<223>  Any amino acid

<400>  1036

Gly Ala His Ala Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val 
1               5                   10                  15      


Ala Pro Gly Lys Thr Ala Thr Ile Pro Cys Gly Gly Asn Asn Ile Glu 
            20                  25                  30          


Ser Lys Ser Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val 
        35                  40                  45              


Leu Val Ile Tyr Asp Asp Thr Asp Arg Pro Ser Gly Ile Pro Glu Arg 
    50                  55                  60                  


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Val Glu Ala Gly Asp Glu Ala Asp Tyr Phe Cys Gln Val Trp Asp Ser 
                85                  90                  95      


His Ser Asp His Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Ser Gly Gly Ser Thr Ile Thr Ser Tyr Asn Val Tyr Tyr Thr Lys Leu 
        115                 120                 125             


Ser Ser Ser Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser Tyr Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Glu His Glu Trp Xaa Ala Gly Ala Phe 
225                 230                 235                 240 


Asp Ile Trp Gly Xaa Gly Thr Met Val Thr Val Ser Ser Ala Ser Gly 
                245                 250                 255     


Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His His His 
            260                 265                 270         


His His His 
        275 


<210>  1037
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  1037
ggcgcgcatg cccagccagt gctgactcag cccccctcgg tgtcagtggc cccgggacag       60

acggccaaga tcacctgtgg gggaaacaac attggaagta aaagtgtgca ctggtaccag      120

cagaagccag gccaggcccc tgtgctggtc gtctatgatg atagcgaccg gccctcaggg      180

atccctgagc gattctctgg ctccaactct gggaacgcgg ccaccctgac catcagcagg      240

gtcgaagccg gggatgaggc cgactattac tgtcaggtgt gggatagtag tagtggcctt      300

gtcttcggaa ctgggaccaa ggtcaccgtc ctatccggag ggtcgaccat aacttcgtat      360

aatgtatacg atacgaagtt atcctcgagc ggtaccgagg tgcagttgtt ggagtctgga      420

gcagaggtga aaaagccggg ggagtctctg aagatctcct gtaagggttc tggatacagc      480

tttaccagct actggatcgg ctgggtgcgc cagatgcccg ggaaaggcct ggagtggatg      540

gggatcatct atcctggtga ctctgatacc agatacagcc cgtcctccca aggccaggtc      600

accatctcag ccgacaagtc catcagcacc gcctacctgc ggtggagcgg cctgaaggcc      660

tcggacaccg ccatgtatta ctgtgcgaga gtatcgagtg actccggtgc ttttgatatc      720

tggggccaag ggacaatggt caccgtctct tcagctagcg gcaaaccaat cccaaaccca      780

ctgctgggcc tggatagtac tcaccatcac catcaccatt ag                         822


<210>  1038
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic single chain 
       variable fragment

<400>  1038
atgaaatacc tattgcctac ggcagccgct ggattgttat tactcgcagc aagcggcgcg       60

catgcctcct atgagctgac acagccaccc tcggtgtcag tggccccagg aaagacggcc      120

acaattccct gtgggggaaa caacattgag agtaaaagtg tccactggta ccagcagcgg      180

ccaggccagg cccctgtctt ggtcatctat gatgataccg accggccctc agggatccct      240

gagcgattct ctggctccaa ctctgggaac acggccaccc tgaccatcag cggggtcgaa      300

gccggggatg aggccgacta tttctgtcag gtgtgggata gtcatagtga tcatgaggtg      360

ttcggcggag ggaccaagct caccgtccta tccggagggt cgaccataac ttcgtataat      420

gtatactata cgaagttatc ctcgagcggt tccgaggtgc agctggtgga gaccggggga      480

ggcttggtac agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttc      540

agtagttatg aaatgaactg ggtccgccag gctccaggga aggggctgga gtgggtttca      600

tacattagta gtagtggcag taccatatac tacgcagact ctgtgaaggg ccgattcacc      660

atctccagag acaacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag      720

gacacggctg tttattactg tgcgagagag catgagtggg aggcgggcgc ttttgatatc      780

tggggccaag ggacaatggt caccgtctct tcagctagcg gcaaaccaat cccaaaccca      840

ctgctgggcc tggatagtac tcaccatcac catcaccatt ga                         882


<210>  1039
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal sequence

<400>  1039

Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Ala Ala Arg Pro 
            20  


<210>  1040
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal sequence

<400>  1040
gccttaccag tgaccgcctt gctcctgccg ctggccttgc tgctccacgc cgccaggccg       60


<210>  1041
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  1041
ggtggatccg ga                                                           12


<210>  1042
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  1042
atcgggctag c                                                            11


<210>  1043
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Spacer

<400>  1043
gctactaact tcagcctgct gaagcaggct ggagacgtgg aggagaaccc tggacct          57


<210>  1044
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1044

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1045

<400>  1045
000

<210>  1046

<400>  1046
000

<210>  1047

<400>  1047
000

<210>  1048

<400>  1048
000

<210>  1049

<400>  1049
000

<210>  1050

<400>  1050
000

<210>  1051

<400>  1051
000

<210>  1052

<400>  1052
000

<210>  1053

<400>  1053
000

<210>  1054

<400>  1054
000

<210>  1055

<400>  1055
000

<210>  1056

<400>  1056
000

<210>  1057

<400>  1057
000

<210>  1058

<400>  1058
000

<210>  1059

<400>  1059
000

<210>  1060

<400>  1060
000

<210>  1061

<400>  1061
000

<210>  1062

<400>  1062
000

<210>  1063

<400>  1063
000

<210>  1064

<400>  1064
000

<210>  1065

<400>  1065
000

<210>  1066

<400>  1066
000

<210>  1067

<400>  1067
000

<210>  1068

<400>  1068
000

<210>  1069

<400>  1069
000

<210>  1070
<211>  3709
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1070
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggatcctaa                 3709


<210>  1071
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1071
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1072
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1072

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser 
    530                 535                 540         


<210>  1073
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1073
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggatcctaa                                                             1629


<210>  1074
<211>  1049
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1074

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln 
            500                 505                 510         


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
        515                 520                 525             


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
    530                 535                 540                 


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
545                 550                 555                 560 


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
                565                 570                 575     


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
            580                 585                 590         


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
        595                 600                 605             


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
    610                 615                 620                 


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
625                 630                 635                 640 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
                645                 650                 655     


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
            660                 665                 670         


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
        675                 680                 685             


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
    690                 695                 700                 


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
705                 710                 715                 720 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
                725                 730                 735     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
            740                 745                 750         


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
        755                 760                 765             


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
    770                 775                 780                 


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
785                 790                 795                 800 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
                805                 810                 815     


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
            820                 825                 830         


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
    850                 855                 860                 


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
865                 870                 875                 880 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
                885                 890                 895     


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
            900                 905                 910         


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
        915                 920                 925             


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
    930                 935                 940                 


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
945                 950                 955                 960 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
                965                 970                 975     


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
            980                 985                 990         


Glu Leu Met Gln Ala Leu Asn Phe  Asn Ser Glu Thr Val  Pro Gln Lys 
        995                 1000                 1005             


Ser Ser  Leu Glu Glu Pro Asp  Phe Tyr Lys Thr Lys  Ile Lys Leu 
    1010                 1015                 1020             


Cys Ile  Leu Leu His Ala Phe  Arg Ile Arg Ala Val  Thr Ile Asp 
    1025                 1030                 1035             


Arg Val  Met Ser Tyr Leu Asn  Ala Ser Gly Ser 
    1040                 1045                 


<210>  1075
<211>  3150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1075
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atcagctact aacttcagcc tgctgaagca ggctggagac     1500

gtggaggaga accctggacc tatgtgccac caacagctcg tgatcagctg gttctccctg     1560

gtgttcctgg ctagccccct ggtggccatc tgggagctca agaaagacgt gtacgtggtg     1620

gaactggact ggtaccccga cgcccctggc gaaatggtgg tgctgacatg cgacacccct     1680

gaggaggatg gcattacctg gaccctcgat cagagctccg aggtgctggg cagcggcaaa     1740

accctgacca tccaggtgaa ggagtttggc gatgccggcc agtacacatg tcacaagggc     1800

ggcgaggtgc tgagccactc cctgctgctg ctccacaaga aggaagatgg catctggagc     1860

accgacattc tgaaggatca gaaggagccc aagaacaaga cattcctgag gtgtgaggcc     1920

aagaactaca gcggcaggtt tacctgctgg tggctgacaa caatcagcac cgacctcaca     1980

ttctccgtca agtcctccag gggttcttcc gaccctcaag gcgtgacatg cggcgctgcc     2040

accctgagcg ctgagagagt caggggcgac aacaaggagt acgagtacag cgtcgaatgt     2100

caggaggaca gcgcctgtcc cgccgctgaa gagagcctgc ctatcgaggt gatggtggac     2160

gccgtgcaca aactgaagta tgagaattac acctccagct tcttcatcag ggacatcatc     2220

aaacccgatc cccccaagaa cctgcagctg aagcctctga agaacagcag acaggtcgaa     2280

gtgtcctggg agtaccctga tacctggtcc acaccccaca gctacttcag cctgaccttt     2340

tgcgtgcagg tgcagggcaa gagcaaaagg gagaagaagg acagggtgtt taccgacaag     2400

acctccgcca cagtgatttg cagaaagaac gcctccatca gcgtgagggc ccaggacagg     2460

tattacagca gctcctggag cgaatgggct agcgtgccct gtagcggagg aggaggcagc     2520

ggaggaggag gttctggagg aggcggcagc agaaacctgc ctgtcgctac ccccgacccc     2580

ggaatgttcc cctgcctgca ccactcccag aacctcctga gggccgtgtc caacatgctg     2640

cagaaggcta gacagaccct cgaattctac ccctgtacca gcgaggagat cgaccatgag     2700

gacatcacca aggataagac cagcaccgtg gaggcttgcc tgcctctgga gctgaccaaa     2760

aacgagagct gcctgaacag cagggaaacc agcttcatta ccaacggctc ctgcctggcc     2820

tccaggaaga catccttcat gatggccctg tgcctcagca gcatctacga ggacctgaag     2880

atgtatcagg tggagtttaa gaccatgaat gccaagctgc tgatggaccc taagaggcag     2940

atcttcctgg accagaatat gctggccgtg attgacgagc tgatgcaggc cctcaacttt     3000

aacagcgaga ccgtgcccca gaaaagcagc ctcgaagagc ctgacttcta caaaaccaag     3060

attaagctgt gtatcctgct gcacgccttc aggatcaggg ccgtgaccat cgacagggtg     3120

atgagctacc tgaacgccag cggatcctga                                      3150


<210>  1076

<400>  1076
000

<210>  1077

<400>  1077
000

<210>  1078

<400>  1078
000

<210>  1079
<211>  4036
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1079
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagtgca     3720

ggtggagaca atcagccccg gcgatggcag gacctttcct aagcgcggcc agacatgcgt     3780

ggtgcactac accggcatgc tgggcgacgg caagaaggtg gacagctccc gggatagaaa     3840

taagcccttc aagtttatgc tgggcaagca ggaagtgatc agaggctggg aggagggagt     3900

ggcacagatg tctgtgggac agggcgccaa gctgacaatc agcccagatt acgcatatgg     3960

agcaaccgga cacccaggaa tcatcccacc ccacgccacc ctggtgttcg acgtggagct     4020

gctggagctg gagtaa                                                     4036


<210>  1080
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1080

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
545                 550                 555                 560 


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp 
                565                 570                 575     


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
            580                 585                 590         


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
        595                 600                 605             


Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
    610                 615                 620                 


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
625                 630                 635                 640 


Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
                645                 650     


<210>  1081
<211>  1956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1081
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagtgca ggtggagaca atcagccccg gcgatggcag gacctttcct     1680

aagcgcggcc agacatgcgt ggtgcactac accggcatgc tgggcgacgg caagaaggtg     1740

gacagctccc gggatagaaa taagcccttc aagtttatgc tgggcaagca ggaagtgatc     1800

agaggctggg aggagggagt ggcacagatg tctgtgggac agggcgccaa gctgacaatc     1860

agcccagatt acgcatatgg agcaaccgga cacccaggaa tcatcccacc ccacgccacc     1920

ctggtgttcg acgtggagct gctggagctg gagtaa                               1956


<210>  1082
<211>  1158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1082

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln 
            500                 505                 510         


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
        515                 520                 525             


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
    530                 535                 540                 


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
545                 550                 555                 560 


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
                565                 570                 575     


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
            580                 585                 590         


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
        595                 600                 605             


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
    610                 615                 620                 


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
625                 630                 635                 640 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
                645                 650                 655     


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
            660                 665                 670         


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
        675                 680                 685             


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
    690                 695                 700                 


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
705                 710                 715                 720 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
                725                 730                 735     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
            740                 745                 750         


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
        755                 760                 765             


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
    770                 775                 780                 


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
785                 790                 795                 800 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
                805                 810                 815     


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
            820                 825                 830         


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
    850                 855                 860                 


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
865                 870                 875                 880 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
                885                 890                 895     


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
            900                 905                 910         


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
        915                 920                 925             


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
    930                 935                 940                 


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
945                 950                 955                 960 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
                965                 970                 975     


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
            980                 985                 990         


Glu Leu Met Gln Ala Leu Asn Phe  Asn Ser Glu Thr Val  Pro Gln Lys 
        995                 1000                 1005             


Ser Ser  Leu Glu Glu Pro Asp  Phe Tyr Lys Thr Lys  Ile Lys Leu 
    1010                 1015                 1020             


Cys Ile  Leu Leu His Ala Phe  Arg Ile Arg Ala Val  Thr Ile Asp 
    1025                 1030                 1035             


Arg Val  Met Ser Tyr Leu Asn  Ala Ser Gly Gly Ser  Gly Gly Val 
    1040                 1045                 1050             


Gln Val  Glu Thr Ile Ser Pro  Gly Asp Gly Arg Thr  Phe Pro Lys 
    1055                 1060                 1065             


Arg Gly  Gln Thr Cys Val Val  His Tyr Thr Gly Met  Leu Gly Asp 
    1070                 1075                 1080             


Gly Lys  Lys Val Asp Ser Ser  Arg Asp Arg Asn Lys  Pro Phe Lys 
    1085                 1090                 1095             


Phe Met  Leu Gly Lys Gln Glu  Val Ile Arg Gly Trp  Glu Glu Gly 
    1100                 1105                 1110             


Val Ala  Gln Met Ser Val Gly  Gln Gly Ala Lys Leu  Thr Ile Ser 
    1115                 1120                 1125             


Pro Asp  Tyr Ala Tyr Gly Ala  Thr Gly His Pro Gly  Ile Ile Pro 
    1130                 1135                 1140             


Pro His  Ala Thr Leu Val Phe  Asp Val Glu Leu Leu  Glu Leu Glu 
    1145                 1150                 1155             


<210>  1083
<211>  1956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1083
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagtgca ggtggagaca atcagccccg gcgatggcag gacctttcct     1680

aagcgcggcc agacatgcgt ggtgcactac accggcatgc tgggcgacgg caagaaggtg     1740

gacagctccc gggatagaaa taagcccttc aagtttatgc tgggcaagca ggaagtgatc     1800

agaggctggg aggagggagt ggcacagatg tctgtgggac agggcgccaa gctgacaatc     1860

agcccagatt acgcatatgg agcaaccgga cacccaggaa tcatcccacc ccacgccacc     1920

ctggtgttcg acgtggagct gctggagctg gagtaa                               1956


<210>  1084
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  1084

Met Glu Arg Ala Gly Pro Ser Phe Gly Gln Gln Arg Gln Gln Gln Gln 
1               5                   10                  15      


Pro Gln Gln Gln Lys Gln Gln Gln Arg Asp Gln Asp Ser Val Glu Ala 
            20                  25                  30          


Trp Leu Asp Asp His Trp Asp Phe Thr Phe Ser Tyr Phe Val Arg Lys 
        35                  40                  45              


Ala Thr Arg Glu Met Val Asn Ala Trp Phe Ala Glu Arg Val His Thr 
    50                  55                  60                  


Ile Pro Val Cys Lys Glu Gly Ile Arg Gly His Thr Glu Ser Cys Ser 
65                  70                  75                  80  


Cys Pro Leu Gln Gln Ser Pro Arg Ala Asp Asn Ser Ala Pro Gly Thr 
                85                  90                  95      


Pro Thr Arg Lys Ile Ser Ala Ser Glu Phe Asp Arg Pro Leu Arg Pro 
            100                 105                 110         


Ile Val Val Lys Asp Ser Glu Gly Thr Val Ser Phe Leu Ser Asp Ser 
        115                 120                 125             


Glu Lys Lys Glu Gln Met Pro Leu Thr Pro Pro Arg Phe Asp His Asp 
    130                 135                 140                 


Glu Gly Asp Gln Cys Ser Arg Leu Leu Glu Leu Val Lys Asp Ile Ser 
145                 150                 155                 160 


Ser His Leu Asp Val Thr Ala Leu Cys His Lys Ile Phe Leu His Ile 
                165                 170                 175     


His Gly Leu Ile Ser Ala Asp Arg Tyr Ser Leu Phe Leu Val Cys Glu 
            180                 185                 190         


Asp Ser Ser Asn Asp Lys Phe Leu Ile Ser Arg Leu Phe Asp Val Ala 
        195                 200                 205             


Glu Gly Ser Thr Leu Glu Glu Val Ser Asn Asn Cys Ile Arg Leu Glu 
    210                 215                 220                 


Trp Asn Lys Gly Ile Val Gly His Val Ala Ala Leu Gly Glu Pro Leu 
225                 230                 235                 240 


Asn Ile Lys Asp Ala Tyr Glu Asp Pro Arg Phe Asn Ala Glu Val Asp 
                245                 250                 255     


Gln Ile Thr Gly Tyr Lys Thr Gln Ser Ile Leu Cys Met Pro Ile Lys 
            260                 265                 270         


Asn His Arg Glu Glu Val Val Gly Val Ala Gln Ala Ile Asn Lys Lys 
        275                 280                 285             


Ser Gly Asn Gly Gly Thr Phe Thr Glu Lys Asp Glu Lys Asp Phe Ala 
    290                 295                 300                 


Ala Tyr Leu Ala Phe Cys Gly Ile Val Leu His Asn Ala Gln Leu Tyr 
305                 310                 315                 320 


Glu Thr Ser Leu Leu Glu Asn Lys Arg Asn Gln Val Leu Leu Asp Leu 
                325                 330                 335     


Ala Ser Leu Ile Phe Glu Glu Gln Gln Ser Leu Glu Val Ile Leu Lys 
            340                 345                 350         


Lys Ile Ala Ala Thr Ile Ile Ser Phe Met Gln Val Gln Lys Cys Thr 
        355                 360                 365             


Ile Phe Ile Val Asp Glu Asp Cys Ser Asp Ser Phe Ser Ser Val Phe 
    370                 375                 380                 


His Met Glu Cys Glu Glu Leu Glu Lys Ser Ser Asp Thr Leu Thr Arg 
385                 390                 395                 400 


Glu His Asp Ala Asn Lys Ile Asn Tyr Met Tyr Ala Gln Tyr Val Lys 
                405                 410                 415     


Asn Thr Met Glu Pro Leu Asn Ile Pro Asp Val Ser Lys Asp Lys Arg 
            420                 425                 430         


Phe Pro Trp Thr Thr Glu Asn Thr Gly Asn Val Asn Gln Gln Cys Ile 
        435                 440                 445             


Arg Ser Leu Leu Cys Thr Pro Ile Lys Asn Gly Lys Lys Asn Lys Val 
    450                 455                 460                 


Ile Gly Val Cys Gln Leu Val Asn Lys Met Glu Glu Asn Thr Gly Lys 
465                 470                 475                 480 


Val Lys Pro Phe Asn Arg Asn Asp Glu Gln Phe Leu Glu Ala Phe Val 
                485                 490                 495     


Ile Phe Cys Gly Leu Gly Ile Gln Asn Thr Gln Met Tyr Glu Ala Val 
            500                 505                 510         


Glu Arg Ala Met Ala Lys Gln Met Val Thr Leu Glu Val Leu Ser Tyr 
        515                 520                 525             


His Ala Ser Ala Ala Glu Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala 
    530                 535                 540                 


Ala Ala Val Val Pro Ser Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser 
545                 550                 555                 560 


Phe Ser Asp Phe Glu Leu Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile 
                565                 570                 575     


Arg Met Phe Thr Asp Leu Asn Leu Val Gln Asn Phe Gln Met Lys His 
            580                 585                 590         


Glu Val Leu Cys Arg Trp Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys 
        595                 600                 605             


Asn Val Ala Tyr His Asn Trp Arg His Ala Phe Asn Thr Ala Gln Cys 
    610                 615                 620                 


Met Phe Ala Ala Leu Lys Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp 
625                 630                 635                 640 


Leu Glu Ile Leu Ala Leu Leu Ile Ala Ala Leu Ser His Asp Leu Asp 
                645                 650                 655     


His Arg Gly Val Asn Asn Ser Tyr Ile Gln Arg Ser Glu His Pro Leu 
            660                 665                 670         


Ala Gln Leu Tyr Cys His Ser Ile Met Glu His His His Phe Asp Gln 
        675                 680                 685             


Cys Leu Met Ile Leu Asn Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu 
    690                 695                 700                 


Ser Ile Glu Glu Tyr Lys Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile 
705                 710                 715                 720 


Leu Ala Thr Asp Leu Ala Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe 
                725                 730                 735     


Glu Leu Ile Arg Lys Asn Gln Phe Asn Leu Glu Asp Pro His Gln Lys 
            740                 745                 750         


Glu Leu Phe Leu Ala Met Leu Met Thr Ala Cys Asp Leu Ser Ala Ile 
        755                 760                 765             


Thr Lys Pro Trp Pro Ile Gln Gln Arg Ile Ala Glu Leu Val Ala Thr 
    770                 775                 780                 


Glu Phe Phe Asp Gln Gly Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu 
785                 790                 795                 800 


Pro Thr Asp Leu Met Asn Arg Glu Lys Lys Asn Lys Ile Pro Ser Met 
                805                 810                 815     


Gln Val Gly Phe Ile Asp Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu 
            820                 825                 830         


Thr His Val Ser Glu Asp Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys 
        835                 840                 845             


Asn Arg Gln Lys Trp Gln Ala Leu Ala Glu Gln Gln Glu Lys Met Leu 
    850                 855                 860                 


Ile Asn Gly Glu Ser Gly Gln Ala Lys Arg Asn 
865                 870                 875 


<210>  1085
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  1085

Glu Glu Thr Arg Glu Leu Gln Ser Leu Ala Ala Ala Val Val Pro Ser 
1               5                   10                  15      


Ala Gln Thr Leu Lys Ile Thr Asp Phe Ser Phe Ser Asp Phe Glu Leu 
            20                  25                  30          


Ser Asp Leu Glu Thr Ala Leu Cys Thr Ile Arg Met Phe Thr Asp Leu 
        35                  40                  45              


Asn Leu Val Gln Asn Phe Gln Met Lys His Glu Val Leu Cys Arg Trp 
    50                  55                  60                  


Ile Leu Ser Val Lys Lys Asn Tyr Arg Lys Asn Val Ala Tyr His Asn 
65                  70                  75                  80  


Trp Arg His Ala Phe Asn Thr Ala Gln Cys Met Phe Ala Ala Leu Lys 
                85                  90                  95      


Ala Gly Lys Ile Gln Asn Lys Leu Thr Asp Leu Glu Ile Leu Ala Leu 
            100                 105                 110         


Leu Ile Ala Ala Leu Ser His Asp Leu Asp His Arg Gly Val Asn Asn 
        115                 120                 125             


Ser Tyr Ile Gln Arg Ser Glu His Pro Leu Ala Gln Leu Tyr Cys His 
    130                 135                 140                 


Ser Ile Met Glu His His His Phe Asp Gln Cys Leu Met Ile Leu Asn 
145                 150                 155                 160 


Ser Pro Gly Asn Gln Ile Leu Ser Gly Leu Ser Ile Glu Glu Tyr Lys 
                165                 170                 175     


Thr Thr Leu Lys Ile Ile Lys Gln Ala Ile Leu Ala Thr Asp Leu Ala 
            180                 185                 190         


Leu Tyr Ile Lys Arg Arg Gly Glu Phe Phe Glu Leu Ile Arg Lys Asn 
        195                 200                 205             


Gln Phe Asn Leu Glu Asp Pro His Gln Lys Glu Leu Phe Leu Ala Met 
    210                 215                 220                 


Leu Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Pro Ile 
225                 230                 235                 240 


Gln Gln Arg Ile Ala Glu Leu Val Ala Thr Glu Phe Phe Asp Gln Gly 
                245                 250                 255     


Asp Arg Glu Arg Lys Glu Leu Asn Ile Glu Pro Thr Asp Leu Met Asn 
            260                 265                 270         


Arg Glu Lys Lys Asn Lys Ile Pro Ser Met Gln Val Gly Phe Ile Asp 
        275                 280                 285             


Ala Ile Cys Leu Gln Leu Tyr Glu Ala Leu Thr His Val Ser Glu Asp 
    290                 295                 300                 


Cys Phe Pro Leu Leu Asp Gly Cys Arg Lys Asn Arg Gln Lys Trp Gln 
305                 310                 315                 320 


Ala Leu Ala Glu Gln Gln 
                325     


<210>  1086
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  1086

Met Gly Glu Thr Leu Gly Asp Ser Pro Ile Asp Pro Glu Ser Asp Ser 
1               5                   10                  15      


Phe Thr Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu Met Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210>  1087
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1087

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210>  1088
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1088

Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu 
1               5                   10                  15      


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
            20                  25                  30          


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
        35                  40                  45              


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
    50                  55                  60                  


Pro Ser Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
65                  70                  75                  80  


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
                85                  90                  95      


Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
            100                 105                 110         


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu 
        115                 120                 125             


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
    130                 135                 140                 


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
145                 150                 155             


<210>  1089
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1089

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Pro Glu 
            100                 105             


<210>  1090
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1090

Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
            100                 105             


<210>  1091
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1091

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  1092
<211>  2761
<212>  DNA
<213>  Homo sapiens

<400>  1092
gggcatacag ttgttccatc ccgacatgaa ctcagcctcc cgtctgaccg ccccttggcc       60

ttccttcttc ctcgatctgt ggaacccagg gaatctgcct agtgctgtct ccaagcacct      120

tggccatgat gtaaacccag agaaattagc atctccatct ccttccttat tccccaccca      180

aaagtcattt cctcttagtt cattacctgg gattttgatg tctatgttcc ctcctcgtta      240

ttgatacaca cacagagaga gacaaacaaa aaaggaactt cttgaaattc ccccagaagg      300

ttttgagagt tgttttcaat gttgcaacaa gtcagtttct agtttaagtt tccatcagaa      360

aggagtagag tatataagtt ccagtaccag caacagcagc agaagaaaca acatctgttt      420

cagggccatt ggactctccg tcctgcccag agcaagatgt gtcaccagca gttggtcatc      480

tcttggtttt ccctggtttt tctggcatct cccctcgtgg ccatatggga actgaagaaa      540

gatgtttatg tcgtagaatt ggattggtat ccggatgccc ctggagaaat ggtggtcctc      600

acctgtgaca cccctgaaga agatggtatc acctggacct tggaccagag cagtgaggtc      660

ttaggctctg gcaaaaccct gaccatccaa gtcaaagagt ttggagatgc tggccagtac      720

acctgtcaca aaggaggcga ggttctaagc cattcgctcc tgctgcttca caaaaaggaa      780

gatggaattt ggtccactga tattttaaag gaccagaaag aacccaaaaa taagaccttt      840

ctaagatgcg aggccaagaa ttattctgga cgtttcacct gctggtggct gacgacaatc      900

agtactgatt tgacattcag tgtcaaaagc agcagaggct cttctgaccc ccaaggggtg      960

acgtgcggag ctgctacact ctctgcagag agagtcagag gggacaacaa ggagtatgag     1020

tactcagtgg agtgccagga ggacagtgcc tgcccagctg ctgaggagag tctgcccatt     1080

gaggtcatgg tggatgccgt tcacaagctc aagtatgaaa actacaccag cagcttcttc     1140

atcagggaca tcatcaaacc tgacccaccc aagaacttgc agctgaagcc attaaagaat     1200

tctcggcagg tggaggtcag ctgggagtac cctgacacct ggagtactcc acattcctac     1260

ttctccctga cattctgcgt tcaggtccag ggcaagagca agagagaaaa gaaagataga     1320

gtcttcacgg acaagacctc agccacggtc atctgccgca aaaatgccag cattagcgtg     1380

cgggcccagg accgctacta tagctcatct tggagcgaat gggcatctgt gccctgcagt     1440

taggttctga tccaggatga aaatttggag gaaaagtgga agatattaag caaaatgttt     1500

aaagacacaa cggaatagac ccaaaaagat aatttctatc tgatttgctt taaaacgttt     1560

ttttaggatc acaatgatat ctttgctgta tttgtatagt tagatgctaa atgctcattg     1620

aaacaatcag ctaatttatg tatagatttt ccagctctca agttgccatg ggccttcatg     1680

ctatttaaat atttaagtaa tttatgtatt tattagtata ttactgttat ttaacgtttg     1740

tctgccagga tgtatggaat gtttcatact cttatgacct gatccatcag gatcagtccc     1800

tattatgcaa aatgtgaatt taattttatt tgtactgaca acttttcaag caaggctgca     1860

agtacatcag ttttatgaca atcaggaaga atgcagtgtt ctgataccag tgccatcata     1920

cacttgtgat ggatgggaac gcaagagata cttacatgga aacctgacaa tgcaaacctg     1980

ttgagaagat ccaggagaac aagatgctag ttcccatgtc tgtgaagact tcctggagat     2040

ggtgttgata aagcaattta gggccactta cacttctaag caagtttaat ctttggatgc     2100

ctgaatttta aaagggctag aaaaaaatga ttgaccagcc tgggaaacat aacaagaccc     2160

cgtctctaca aaaaaaattt aaaattagcc aggcgtggtg gctcatgctt gtggtcccag     2220

ctgttcagga ggatgaggca ggaggatctc ttgagcccag gaggtcaagg ctatggtgag     2280

ccgtgattgt gccactgcat accagcctag gtgacagaat gagaccctgt ctcaaaaaaa     2340

aaaatgattg aaattaaaat tcagctttag cttccatggc agtcctcacc cccacctctc     2400

taaaagacac aggaggatga cacagaaaca ccgtaagtgt ctggaaggca aaaagatctt     2460

aagattcaag agagaggaca agtagttatg gctaaggaca tgaaattgtc agaatggcag     2520

gtggcttctt aacagccctg tgagaagcag acagatgcaa agaaaatctg gaatcccttt     2580

ctcattagca tgaatgaacc tgatacacaa ttatgaccag aaaatatggc tccatgaagg     2640

tgctactttt aagtaatgta tgtgcgctct gtaaagtgat tacatttgtt tcctgtttgt     2700

ttatttattt atttattttt gcattctgag gctgaactaa taaaaactct tctttgtaat     2760

c                                                                     2761


<210>  1093
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1093

Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210>  1094
<211>  1522
<212>  DNA
<213>  Homo sapiens

<400>  1094
acggggcgtc cggctaaggc cggggaccca gggtggtggg cggggtgtcc cgcccgcctg       60

tggaccccgc gcagtaactg cgaacatttc gctttcattt tgggccgagc tggaggcggc      120

ggggccgtcc cggaacggct gcggccgggc accccgggag ttaatccgaa agcgccgcaa      180

gccccgcggg ccggccgcac cgcacgtgtc accgagaagc tgatgtagag agagacacag      240

aaggagacag aaagcaagag accagagtcc cgggaaagtc ctgccgcgcc tcgggacaat      300

tataaaaatg tggccccctg ggtcagcctc ccagccaccg ccctcacctg ccgcggccac      360

aggtctgcat ccagcggctc gccctgtgtc cctgcagtgc cggctcagca tgtgtccagc      420

gcgcagcctc ctccttgtgg ctaccctggt cctcctggac cacctcagtt tggccagaaa      480

cctccccgtg gccactccag acccaggaat gttcccatgc cttcaccact cccaaaacct      540

gctgagggcc gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg      600

cacttctgaa gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc      660

ctgtttacca ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt      720

cataactaat gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct      780

tagtagtatt tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa      840

gcttctgatg gatcctaaga ggcagatctt tctagatcaa aacatgctgg cagttattga      900

tgagctgatg caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga      960

agaaccggat ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat     1020

tcgggcagtg actattgata gagtgatgag ctatctgaat gcttcctaaa aagcgaggtc     1080

cctccaaacc gttgtcattt ttataaaact ttgaaatgag gaaactttga taggatgtgg     1140

attaagaact agggaggggg aaagaaggat gggactatta catccacatg atacctctga     1200

tcaagtattt ttgacattta ctgtggataa attgttttta agttttcatg aatgaattgc     1260

taagaaggga aaatatccat cctgaaggtg tttttcattc actttaatag aagggcaaat     1320

atttataagc tatttctgta ccaaagtgtt tgtggaaaca aacatgtaag cataacttat     1380

tttaaaatat ttatttatat aacttggtaa tcatgaaagc atctgagcta acttatattt     1440

atttatgtta tatttattaa attatttatc aagtgtattt gaaaaatatt tttaagtgtt     1500

ctaaaaataa aagtattgaa tt                                              1522


<210>  1095
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  1095

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  1096
<211>  2472
<212>  DNA
<213>  Homo sapiens

<400>  1096
actccgggtg gcaggcgccc gggggaatcc cagctgactc gctcactgcc ttcgaagtcc       60

ggcgcccccc gggagggaac tgggtggccg caccctcccg gctgcggtgg ctgtcgcccc      120

ccaccctgca gccaggactc gatggaggta cagagctcgg cttctttgcc ttgggagggg      180

agtggtggtg gttgaaaggg cgatggaatt ttccccgaaa gcctacgccc agggcccctc      240

ccagctccag cgttaccctc cggtctatcc tactggccga gctgccccgc cttctcatgg      300

ggaaaactta gccgcaactt caatttttgg tttttccttt aatgacactt ctgaggctct      360

cctagccatc ctcccgcttc cggaggagcg cagatcgcag gtccctttgc ccctggcgtg      420

cgactcccta ctgcgctgcg ctcttacggc gttccaggct gctggctagc gcaaggcggg      480

ccgggcaccc cgcgctccgc tgggagggtg agggacgcgc gtctggcggc cccagccaag      540

ctgcgggttt ctgagaagac gctgtcccgc agccctgagg gctgagttct gcacccagtc      600

aagctcagga aggccaagaa aagaatccat tccaatatat ggccatgtgg ctctttggag      660

caatgttcca tcatgttcca tgctgctgac gtcacatgga gcacagaaat caatgttagc      720

agatagccag cccatacaag atcgtattgt attgtaggag gcattgtgga tggatggctg      780

ctggaaaccc cttgccatag ccagctcttc ttcaatactt aaggatttac cgtggctttg      840

agtaatgaga atttcgaaac cacatttgag aagtatttcc atccagtgct acttgtgttt      900

acttctaaac agtcattttc taactgaagc tggcattcat gtcttcattt tgggctgttt      960

cagtgcaggg cttcctaaaa cagaagccaa ctgggtgaat gtaataagtg atttgaaaaa     1020

aattgaagat cttattcaat ctatgcatat tgatgctact ttatatacgg aaagtgatgt     1080

tcaccccagt tgcaaagtaa cagcaatgaa gtgctttctc ttggagttac aagttatttc     1140

acttgagtcc ggagatgcaa gtattcatga tacagtagaa aatctgatca tcctagcaaa     1200

caacagtttg tcttctaatg ggaatgtaac agaatctgga tgcaaagaat gtgaggaact     1260

ggaggaaaaa aatattaaag aatttttgca gagttttgta catattgtcc aaatgttcat     1320

caacacttct tgattgcaat tgattctttt taaagtgttt ctgttattaa caaacatcac     1380

tctgctgctt agacataaca aaacactcgg catttcaaat gtgctgtcaa aacaagtttt     1440

tctgtcaaga agatgatcag accttggatc agatgaactc ttagaaatga aggcagaaaa     1500

atgtcattga gtaatatagt gactatgaac ttctctcaga cttactttac tcattttttt     1560

aatttattat tgaaattgta catatttgtg gaataatgta aaatgttgaa taaaaatatg     1620

tacaagtgtt gttttttaag ttgcactgat attttacctc ttattgcaaa atagcatttg     1680

tttaagggtg atagtcaaat tatgtattgg tggggctggg taccaatgct gcaggtcaac     1740

agctatgctg gtaggctcct gccagtgtgg aaccactgac tactggctct cattgacttc     1800

cttactaagc atagcaaaca gaggaagaat ttgttatcag taagaaaaag aagaactata     1860

tgtgaatcct cttctttata ctgtaattta gttattgatg tataaagcaa ctgttatgaa     1920

ataaagaaat tgcaataact ggcatataat gtccatcagt aaatcttggt ggtggtggca     1980

ataataaact tctactgata ggtagaatgg tgtgcaagct tgtccaatca cggattgcag     2040

gccacatgcg gcccaggaca actttgaatg tggcccaaca caaattcata aactttcata     2100

catctcgttt ttagctcatc agctatcatt agcggtagtg tatttaaagt gtggcccaag     2160

acaattcttc ttattccaat gtggcccagg gaaatcaaaa gattggatgc ccctggtata     2220

gaaaactaat agtgacagtg ttcatatttc atgctttccc aaatacaggt attttatttt     2280

cacattcttt ttgccatgtt tatataataa taaagaaaaa ccctgttgat ttgttggagc     2340

cattgttatc tgacagaaaa taattgttta tattttttgc actacactgt ctaaaattag     2400

caagctctct tctaatggaa ctgtaagaaa gatgaaatat ttttgtttta ttataaattt     2460

atttcacctt aa                                                         2472


<210>  1097
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  1097

Met Ala Pro Arg Arg Ala Arg Gly Cys Arg Thr Leu Gly Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Arg Pro Pro Ala Thr Arg Gly Ile Thr 
            20                  25                  30          


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
        35                  40                  45              


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
    50                  55                  60                  


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
65                  70                  75                  80  


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
                85                  90                  95      


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
            100                 105                 110         


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
        115                 120                 125             


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
    130                 135                 140                 


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
145                 150                 155                 160 


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
                165                 170                 175     


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
            180                 185                 190         


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
        195                 200                 205             


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
    210                 215                 220                 


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
225                 230                 235                 240 


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
                245                 250                 255     


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
            260                 265         


<210>  1098
<211>  1626
<212>  DNA
<213>  Homo sapiens

<400>  1098
tggcggggcg gcaggtccca gagcagcgct cgccacctcc ccccggcctg ggcagcgctc       60

gcccggggag tccagcggtg tcctgtggag ctgccgccat ggccccgcgg cgggcgcgcg      120

gctgccggac cctcggtctc ccggcgctgc tactgctgct gctgctccgg ccgccggcga      180

cgcggggcat cacgtgccct ccccccatgt ccgtggaaca cgcagacatc tgggtcaaga      240

gctacagctt gtactccagg gagcggtaca tttgtaactc tggtttcaag cgtaaagccg      300

gcacgtccag cctgacggag tgcgtgttga acaaggccac gaatgtcgcc cactggacaa      360

cccccagtct caaatgcatt agagaccctg ccctggttca ccaaaggcca gcgccaccct      420

ccacagtaac gacggcaggg gtgaccccac agccagagag cctctcccct tctggaaaag      480

agcccgcagc ttcatctccc agctcaaaca acacagcggc cacaacagca gctattgtcc      540

cgggctccca gctgatgcct tcaaaatcac cttccacagg aaccacagag ataagcagtc      600

atgagtcctc ccacggcacc ccctctcaga caacagccaa gaactgggaa ctcacagcat      660

ccgcctccca ccagccgcca ggtgtgtatc cacagggcca cagcgacacc actgtggcta      720

tctccacgtc cactgtcctg ctgtgtgggc tgagcgctgt gtctctcctg gcatgctacc      780

tcaagtcaag gcaaactccc ccgctggcca gcgttgaaat ggaagccatg gaggctctgc      840

cggtgacttg ggggaccagc agcagagatg aagacttgga aaactgctct caccacctat      900

gaaactcggg gaaaccagcc cagctaagtc cggagtgaag gagcctctct gctttagcta      960

aagacgactg agaagaggtg caaggaagcg ggctccagga gcaagctcac caggcctctc     1020

agaagtccca gcaggatctc acggactgcc gggtcggcgc ctcctgcgcg agggagcagg     1080

ttctccgcat tcccatgggc accacctgcc tgcctgtcgt gccttggacc cagggcccag     1140

cttcccagga gagaccaaag gcttctgagc aggattttta tttcattaca gtgtgagctg     1200

cctggaatac atgtggtaat gaaataaaaa ccctgccccg aatcttccgt ccctcatcct     1260

aactttcagt tcacagagaa aagtgacata cccaaagctc tctgtcaatt acaaggcttc     1320

tcctggcgtg ggagacgtct acagggaaga caccagcgtt tgggcttcta accaccctgt     1380

ctccagctgc tctgcacaca tggacaggga cctgggaaag gtgggagaga tgctgagccc     1440

agcgaatcct ctccattgaa ggattcagga agaagaaaac tcaactcagt gccattttac     1500

gaatatatgc gtttatattt atacttcctt gtctattata tctatacatt atatattatt     1560

tgtattttga cattgtacct tgtataaaca aaataaaaca tctattttca atatttttaa     1620

aatgca                                                                1626


<210>  1099
<211>  1184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  1099
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccactgagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgtgcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtga                      1184


<210>  1100
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  1100
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  1101
<211>  512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  1101
atcgatgggt aggggaggcg cttttcccaa ggcagtctgg agcatgcgct ttagcagccc       60

cgctgggcac ttggcgctac acaagtggcc tctggcctcg cacacattcc acatccaccg      120

gtaggcgcca accggctccg ttctttggtg gccccttcgc gccaccttct actcctcccc      180

tagtcaggaa gttccccccc gccccgcagc tcgcgtcgtg caggacgtga caaatggaag      240

tagcacgtct cactagtctc gtgcagatgg acagcaccgc tgagcaatgg aagcgggtag      300

gcctttgggg cagcggccaa tagcagcttt gctccttcgc tttctgggct cagaggctgg      360

gaaggggtgg gtccgggggc gggctcaggg gcgggctcag gggcggggcg ggcgcccgaa      420

ggtcctccgg aggcccggca ttctgcacgc ttcaaaagcg cacgtctgcc gcgctgttct      480

cctcttcctc atctccgggc ctttcgctcg ag                                    512


<210>  1102
<211>  507
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  1102
atcgatgggt aggggaggcg cttttcccaa ggcagtctgg agcatgcgct ttagcagccc       60

cgctgggcac ttggcgctac acaagtggcc tctggcctcg cacacattcc acatccaccg      120

gtaggcgcca accggctccg ttctttggtg gccccttcgc gccaccttct actcctcccc      180

tagtcaggaa gttccccccc gccccgcagc tcgcgtcgtg caggacgtga caaatggaag      240

tagcacgtct cactagtctc gtgcagatgg acagcaccgc tgagcaatgg aagcgggtag      300

gcctttgggg cagcggccaa tagcagcttt gctccttcgc tttctgggct cagaggctgg      360

gaaggggtgg gtccgggggc gggctcaggg gcgggctcag gggcggggcg ggcgcccgaa      420

ggtcctccgg aggcccggca ttctgcacgc ttcaaaagcg cacgtctgcc gcgctgttct      480

cctcttcctc atctccgggc ctttcgc                                          507


<210>  1103
<211>  1184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Promoter

<400>  1103
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccactgagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtga                      1184


<210>  1104
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1104

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1105
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1105

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
545                 550                 555                 560 


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp 
                565                 570                 575     


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
            580                 585                 590         


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
        595                 600                 605             


Gln Met Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
    610                 615                 620                 


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
625                 630                 635                 640 


Leu Val Phe Asp Val Glu Leu Leu Glu Leu Glu 
                645                 650     


<210>  1106
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1106
atggcactgc ctgtgaccgc cctgctgctg ccactggccc tgctgctgca cgcagccagg       60

cccgacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gccgggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagcc gcctgcactc cggagtgcct      240

tctaggttca gcggctccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggcagcg gaggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggcc tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagacaaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctcgc ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgaggcc cgaggcatgt aggcctgcag caggaggcgc cgtgcacacc      900

aggggcctgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtggc      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggccggaa gaagctgctg     1020

tacatcttca agcagccctt catgaggccc gtgcagacaa cccaggagga ggacggctgc     1080

agctgtcggt tcccagagga ggaggaggga ggatgtgagc tgagggtgaa gttttctagg     1140

agcgccgatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggcaggagag aggagtacga cgtgctggat aagaggaggg gaagggaccc cgagatggga     1260

ggcaagccaa ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagagc ggcgcagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc actgcacatg     1440

caggccctgc ctccaaggtg a                                               1461


<210>  1107
<211>  1956
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1107
atgtgccacc agcagctggt catcagctgg ttctccctgg tgtttctggc atccccactg       60

gtggcaatct gggagctgaa gaaggacgtg tacgtggtgg agctggactg gtatcccgat      120

gcccctggcg agatggtggt gctgacctgc gacacacctg aggaggatgg catcacctgg      180

acactggatc agagctccga ggtgctggga agcggcaaga ccctgacaat ccaggtgaag      240

gagttcggcg acgccggcca gtacacatgt cacaagggcg gcgaggtgct gtctcacagc      300

ctgctgctgc tgcacaagaa ggaggacggc atttggtcca cagacatcct gaaggatcag      360

aaggagccaa agaacaagac cttcctgcgg tgcgaggcca agaattatag cggccggttc      420

acctgttggt ggctgaccac aatcagcacc gatctgacat tttccgtgaa gtctagccgg      480

ggctcctctg acccacaggg agtgacatgc ggagcagcca ccctgtccgc cgagcgggtg      540

agaggcgata acaaggagta cgagtattcc gtggagtgcc aggaggactc tgcctgtcct      600

gcagcagagg agagcctgcc aatcgaagtg atggtggatg ccgtgcacaa gctgaagtac      660

gagaattata caagctcctt ctttatcagg gacatcatca agcctgatcc ccctaagaac      720

ctgcagctga agccactgaa gaattctcgc caggtggagg tgagctggga gtacccagac      780

acctggtcca caccccactc ttatttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

tccaagcggg agaagaagga cagagtgttc accgataaga catctgccac cgtgatctgt      900

cggaagaacg cctccatctc tgtgagggcc caggatcgct actattctag ctcctggagc      960

gagtgggcat ccgtgccatg ttctggagga ggaggaagcg gaggaggagg atccggcgga     1020

ggaggctcta gaaatctgcc agtggcaacc cctgacccag gaatgttccc ttgcctgcac     1080

cacagccaga acctgctgag ggccgtgtcc aatatgctgc agaaggcccg ccagacactg     1140

gagttttacc cttgtaccag cgaggagatc gaccacgagg atatcacaaa ggataagacc     1200

tccacagtgg aggcctgcct gccactggag ctgaccaaga acgagagctg tctgaattcc     1260

cgggagacat ctttcatcac caacggcagc tgcctggcct ccagaaagac atcttttatg     1320

atggccctgt gcctgtctag catctacgag gacctgaaga tgtatcaggt ggagttcaag     1380

accatgaacg ccaagctgct gatggaccct aagaggcaga tctttctgga tcagaatatg     1440

ctggccgtga tcgacgagct gatgcaggcc ctgaacttca atagcgagac agtgccacag     1500

aagtcctctc tggaggagcc cgatttctac aagaccaaga tcaagctgtg catcctgctg     1560

cacgccttta ggatccgcgc cgtgaccatc gaccgcgtga tgtcttatct gaacgcatcc     1620

ggaggatctg gaggagtgca ggtggagaca atcagccccg gcgatggcag gacctttcct     1680

aagcgcggcc agacatgcgt ggtgcactac accggcatgc tgggcgacgg caagaaggtg     1740

gacagctccc gggatagaaa taagcccttc aagtttatgc tgggcaagca ggaagtgatc     1800

agaggctggg aggagggagt ggcacagatg tctgtgggac agggcgccaa gctgacaatc     1860

agcccagatt acgcatatgg agcaaccgga cacccaggaa tcatcccacc ccacgccacc     1920

ctggtgttcg acgtggagct gctggagctg gagtga                               1956


<210>  1108
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  1108
ggtggatccg ga                                                           12


<210>  1109
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  1109

Gly Ser Ser Gly 
1               


<210>  1110
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  1110
ggatccagcg gc                                                           12


<210>  1111
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1111
atctcactta tcgcagcctt ggcagttgat tatgtgatcg gcatggaaaa tgcgatgcca       60

tggaatcttc cggccgacct cgcttggttc aaacgcaaca ccctgaacaa acccgttatt      120

atgggccgac atacatggga aagtatcggc aggccattgc ccggtcggaa aaacataatc      180

ctttcctccc agccgggcac ggacgataga gtgacttggg tcaaatcagt tgacgaggcc      240

attgctgcct gcggcgatgt acccgagatt atggttatcg gaggggggcg agttattgag      300

cagtttctgc ccaaagcgca gaagttgtac cttactcata tagatgcaga ggtagagggc      360

gacacgcatt tccccgacta cgaaccggat gattgggaat ccgtattttc cgaattccac      420

gacgcggatg cccaaaacag tcactcttac tgttttgaaa ttcttgagcg acgc            474


<210>  1112
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Linker

<400>  1112
gttggttcgc taaactgcat cgtggccgtg agccagaaca tgggcatcgg caagaatggc       60

gacctgcctt ggccacctct gaggaacgag ttcagatact ttcagaggat gaccacaacc      120

agctccgtgg agggcaagca gaacctggtc atcatgggca agaagacatg gttctctatc      180

cccgagaaga accgccctct gaagggccgg atcaatctgg tgctgagcag agagctgaag      240

gagccaccac agggagcaca cttcctgagc cggagcctgg acgatgccct gaagctgacc      300

gagcagcccg agctggccaa caaggtggac atggtgtgga tcgtgggcgg ctctagcgtg      360

atcaaggagg ccatgaatca cccaggccac ctgaagctgt tcgtgacaag aatcatgcag      420

gactttgagt ccgatacctt ctttcccgag atcgacctgg agaagtacaa gctgctgcct      480

gagtatccag gcgtgctgtc tgatgtgcag gaggagaagg gcatcaagta caagttcgag      540

gtgtatgaga agaatgat                                                    558


<210>  1113
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1113
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgtcgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  1114
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1114

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ala 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  1115
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1115
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgccgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

tataaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  1116
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1116

Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ala 
1               5                   10                  15      


Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe Arg 
            20                  25                  30          


Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn 
        35                  40                  45              


Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn 
    50                  55                  60                  


Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys 
65                  70                  75                  80  


Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala 
                85                  90                  95      


Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val 
            100                 105                 110         


Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His Pro 
        115                 120                 125             


Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser 
    130                 135                 140                 


Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro 
145                 150                 155                 160 


Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys 
                165                 170                 175     


Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185     


<210>  1117
<211>  558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       Domain (DD)

<400>  1117
gttggttcgc taaactgcat cgtcgctgtg tcccagaaca tgggcgccgg caagaacggg       60

gacctgccct ggccaccgct caggaatgaa ttcagatatt tccagagaat gaccacaacc      120

tcttcagtag aaggtaaaca gaatctggtg attatgggta agaagacctg gttctccatt      180

cctgagaaga atcgaccttt aaagggtaga attaatttag ttctcagcag agaactcaag      240

gaacctccac aaggagctca ttttctttcc agaagtctag atgatgcctt aaaacttact      300

gaacaaccag aattagcaaa taaagtagac atggtctgga tagttggtgg cagttctgtt      360

attaaggaag ccatgaatca cccaggccat cttaaactat ttgtgacaag gatcatgcaa      420

gactttgaaa gtgacacgtt ttttccagaa attgatttgg agaaatataa acttctgcca      480

gaatacccag gtgttctctc tgatgtccag gaggagaaag gcattaagta caaatttgaa      540

gtatatgaga agaatgat                                                    558


<210>  1118
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1118

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Gly Ser 
            500                 505                 510 


<210>  1119
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1119

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser 
                485             


<210>  1120
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1120

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1121
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1121

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Tyr His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1122
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1122

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1123
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1123

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser Ser Gly 
    530                 535                 540                 


Ile Ser Leu Ile Ala Ala Leu Ala Val Asp Tyr Val Ile Gly Met Glu 
545                 550                 555                 560 


Asn Ala Met Pro Trp Asn Leu Pro Ala Asp Leu Ala Trp Phe Lys Arg 
                565                 570                 575     


Asn Thr Leu Asn Lys Pro Val Ile Met Gly Arg His Thr Trp Glu Ser 
            580                 585                 590         


Ile Gly Arg Pro Leu Pro Gly Arg Lys Asn Ile Ile Leu Ser Ser Gln 
        595                 600                 605             


Pro Gly Thr Asp Asp Arg Val Thr Trp Val Lys Ser Val Asp Glu Ala 
    610                 615                 620                 


Ile Ala Ala Cys Gly Asp Val Pro Glu Ile Met Val Ile Gly Gly Gly 
625                 630                 635                 640 


Arg Val Ile Glu Gln Phe Leu Pro Lys Ala Gln Lys Leu Tyr Leu Thr 
                645                 650                 655     


His Ile Asp Ala Glu Val Glu Gly Asp Thr His Phe Pro Asp Tyr Glu 
            660                 665                 670         


Pro Asp Asp Trp Glu Ser Val Phe Ser Glu Phe His Asp Ala Asp Ala 
        675                 680                 685             


Gln Asn Ser His Ser Tyr Cys Phe Glu Ile Leu Glu Arg Arg 
    690                 695                 700         


<210>  1124
<211>  1209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1124

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln 
            500                 505                 510         


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
        515                 520                 525             


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
    530                 535                 540                 


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
545                 550                 555                 560 


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
                565                 570                 575     


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
            580                 585                 590         


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
        595                 600                 605             


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
    610                 615                 620                 


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
625                 630                 635                 640 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
                645                 650                 655     


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
            660                 665                 670         


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
        675                 680                 685             


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
    690                 695                 700                 


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
705                 710                 715                 720 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
                725                 730                 735     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
            740                 745                 750         


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
        755                 760                 765             


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
    770                 775                 780                 


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
785                 790                 795                 800 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
                805                 810                 815     


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
            820                 825                 830         


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
    850                 855                 860                 


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
865                 870                 875                 880 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
                885                 890                 895     


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
            900                 905                 910         


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
        915                 920                 925             


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
    930                 935                 940                 


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
945                 950                 955                 960 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
                965                 970                 975     


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
            980                 985                 990         


Glu Leu Met Gln Ala Leu Asn Phe  Asn Ser Glu Thr Val  Pro Gln Lys 
        995                 1000                 1005             


Ser Ser  Leu Glu Glu Pro Asp  Phe Tyr Lys Thr Lys  Ile Lys Leu 
    1010                 1015                 1020             


Cys Ile  Leu Leu His Ala Phe  Arg Ile Arg Ala Val  Thr Ile Asp 
    1025                 1030                 1035             


Arg Val  Met Ser Tyr Leu Asn  Ala Ser Gly Ser Ser  Gly Ile Ser 
    1040                 1045                 1050             


Leu Ile  Ala Ala Leu Ala Val  Asp Tyr Val Ile Gly  Met Glu Asn 
    1055                 1060                 1065             


Ala Met  Pro Trp Asn Leu Pro  Ala Asp Leu Ala Trp  Phe Lys Arg 
    1070                 1075                 1080             


Asn Thr  Leu Asn Lys Pro Val  Ile Met Gly Arg His  Thr Trp Glu 
    1085                 1090                 1095             


Ser Ile  Gly Arg Pro Leu Pro  Gly Arg Lys Asn Ile  Ile Leu Ser 
    1100                 1105                 1110             


Ser Gln  Pro Gly Thr Asp Asp  Arg Val Thr Trp Val  Lys Ser Val 
    1115                 1120                 1125             


Asp Glu  Ala Ile Ala Ala Cys  Gly Asp Val Pro Glu  Ile Met Val 
    1130                 1135                 1140             


Ile Gly  Gly Gly Arg Val Ile  Glu Gln Phe Leu Pro  Lys Ala Gln 
    1145                 1150                 1155             


Lys Leu  Tyr Leu Thr His Ile  Asp Ala Glu Val Glu  Gly Asp Thr 
    1160                 1165                 1170             


His Phe  Pro Asp Tyr Glu Pro  Asp Asp Trp Glu Ser  Val Phe Ser 
    1175                 1180                 1185             


Glu Phe  His Asp Ala Asp Ala  Gln Asn Ser His Ser  Tyr Cys Phe 
    1190                 1195                 1200             


Glu Ile  Leu Glu Arg Arg 
    1205                 


<210>  1125
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1125

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln 
            500                 505                 510         


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
        515                 520                 525             


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
    530                 535                 540                 


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
545                 550                 555                 560 


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
                565                 570                 575     


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
            580                 585                 590         


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
        595                 600                 605             


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
    610                 615                 620                 


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
625                 630                 635                 640 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
                645                 650                 655     


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
            660                 665                 670         


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
        675                 680                 685             


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
    690                 695                 700                 


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
705                 710                 715                 720 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
                725                 730                 735     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
            740                 745                 750         


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
        755                 760                 765             


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
    770                 775                 780                 


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
785                 790                 795                 800 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
                805                 810                 815     


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
            820                 825                 830         


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
    850                 855                 860                 


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
865                 870                 875                 880 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
                885                 890                 895     


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
            900                 905                 910         


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
        915                 920                 925             


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
    930                 935                 940                 


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
945                 950                 955                 960 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
                965                 970                 975     


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
            980                 985                 990         


Glu Leu Met Gln Ala Leu Asn Phe  Asn Ser Glu Thr Val  Pro Gln Lys 
        995                 1000                 1005             


Ser Ser  Leu Glu Glu Pro Asp  Phe Tyr Lys Thr Lys  Ile Lys Leu 
    1010                 1015                 1020             


Cys Ile  Leu Leu His Ala Phe  Arg Ile Arg Ala Val  Thr Ile Asp 
    1025                 1030                 1035             


Arg Val  Met Ser Tyr Leu Asn  Ala Ser Gly Ser Val  Gly Ser Leu 
    1040                 1045                 1050             


Asn Cys  Ile Val Ala Val Ser  Gln Asn Met Gly Val  Gly Lys Asn 
    1055                 1060                 1065             


Gly Asp  Leu Pro Trp Pro Pro  Leu Arg Asn Glu Phe  Arg Tyr Phe 
    1070                 1075                 1080             


Gln Arg  Met Thr Thr Thr Ser  Ser Val Glu Gly Lys  Gln Asn Leu 
    1085                 1090                 1095             


Val Ile  Met Gly Lys Lys Thr  Trp Phe Ser Ile Pro  Glu Lys Asn 
    1100                 1105                 1110             


Arg Pro  Leu Lys Gly Arg Ile  Asn Leu Val Leu Ser  Arg Glu Leu 
    1115                 1120                 1125             


Lys Glu  Pro Pro Gln Gly Ala  His Phe Leu Ser Arg  Ser Leu Asp 
    1130                 1135                 1140             


Asp Ala  Leu Lys Leu Thr Glu  Gln Pro Glu Leu Ala  Asn Lys Val 
    1145                 1150                 1155             


Asp Met  Val Trp Ile Val Gly  Gly Ser Ser Val Tyr  Lys Glu Ala 
    1160                 1165                 1170             


Met Asn  His Pro Gly His Leu  Lys Leu Phe Val Thr  Arg Ile Met 
    1175                 1180                 1185             


Gln Asp  Phe Glu Ser Asp Thr  Phe Phe Pro Glu Ile  Asp Leu Glu 
    1190                 1195                 1200             


Lys Tyr  Lys Leu Leu Pro Glu  Tyr Pro Gly Val Leu  Ser Asp Val 
    1205                 1210                 1215             


Gln Glu  Glu Lys Gly Ile Lys  Tyr Lys Phe Glu Val  Tyr Glu Lys 
    1220                 1225                 1230             


Asn Asp  
    1235 


<210>  1126
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1126

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln 
            500                 505                 510         


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
        515                 520                 525             


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
    530                 535                 540                 


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
545                 550                 555                 560 


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
                565                 570                 575     


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
            580                 585                 590         


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
        595                 600                 605             


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
    610                 615                 620                 


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
625                 630                 635                 640 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
                645                 650                 655     


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
            660                 665                 670         


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
        675                 680                 685             


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
    690                 695                 700                 


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
705                 710                 715                 720 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
                725                 730                 735     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
            740                 745                 750         


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
        755                 760                 765             


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
    770                 775                 780                 


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
785                 790                 795                 800 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
                805                 810                 815     


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
            820                 825                 830         


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
    850                 855                 860                 


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
865                 870                 875                 880 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
                885                 890                 895     


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
            900                 905                 910         


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
        915                 920                 925             


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
    930                 935                 940                 


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
945                 950                 955                 960 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
                965                 970                 975     


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
            980                 985                 990         


Glu Leu Met Gln Ala Leu Asn Phe  Asn Ser Glu Thr Val  Pro Gln Lys 
        995                 1000                 1005             


Ser Ser  Leu Glu Glu Pro Asp  Phe Tyr Lys Thr Lys  Ile Lys Leu 
    1010                 1015                 1020             


Cys Ile  Leu Leu His Ala Phe  Arg Ile Arg Ala Val  Thr Ile Asp 
    1025                 1030                 1035             


Arg Val  Met Ser Tyr Leu Asn  Ala Ser Gly Ser Val  Gly Ser Leu 
    1040                 1045                 1050             


Asn Cys  Ile Val Ala Val Ser  Gln Asn Met Gly Val  Gly Lys Asn 
    1055                 1060                 1065             


Gly Asp  Leu Pro Trp Pro Pro  Leu Arg Asn Glu Phe  Arg Tyr Phe 
    1070                 1075                 1080             


Gln Arg  Met Thr Thr Thr Ser  Ser Val Glu Gly Lys  Gln Asn Leu 
    1085                 1090                 1095             


Val Ile  Met Gly Lys Lys Thr  Trp Phe Ser Ile Pro  Glu Lys Asn 
    1100                 1105                 1110             


Arg Pro  Leu Lys Gly Arg Ile  Asn Leu Val Leu Ser  Arg Glu Leu 
    1115                 1120                 1125             


Lys Glu  Pro Pro Gln Gly Ala  His Phe Leu Ser Arg  Ser Leu Asp 
    1130                 1135                 1140             


Asp Ala  Leu Lys Leu Thr Glu  Gln Pro Glu Leu Ala  Asn Lys Val 
    1145                 1150                 1155             


Asp Met  Val Trp Ile Val Gly  Gly Ser Ser Val Ile  Lys Glu Ala 
    1160                 1165                 1170             


Met Asn  His Pro Gly His Leu  Lys Leu Phe Val Thr  Arg Ile Met 
    1175                 1180                 1185             


Gln Asp  Phe Glu Ser Asp Thr  Phe Phe Pro Glu Ile  Asp Leu Glu 
    1190                 1195                 1200             


Lys Tyr  Lys Leu Leu Pro Glu  Tyr Pro Gly Val Leu  Ser Asp Val 
    1205                 1210                 1215             


Gln Glu  Glu Lys Gly Ile Lys  Tyr Lys Phe Glu Val  Tyr Glu Lys 
    1220                 1225                 1230             


Asn Asp  
    1235 


<210>  1127
<211>  1235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1127

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys His Gln Gln 
            500                 505                 510         


Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu Ala Ser Pro Leu Val 
        515                 520                 525             


Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
    530                 535                 540                 


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
545                 550                 555                 560 


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
                565                 570                 575     


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
            580                 585                 590         


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
        595                 600                 605             


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
    610                 615                 620                 


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
625                 630                 635                 640 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
                645                 650                 655     


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
            660                 665                 670         


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
        675                 680                 685             


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
    690                 695                 700                 


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
705                 710                 715                 720 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
                725                 730                 735     


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
            740                 745                 750         


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
        755                 760                 765             


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
    770                 775                 780                 


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
785                 790                 795                 800 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
                805                 810                 815     


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
            820                 825                 830         


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        835                 840                 845             


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
    850                 855                 860                 


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
865                 870                 875                 880 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
                885                 890                 895     


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
            900                 905                 910         


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
        915                 920                 925             


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
    930                 935                 940                 


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
945                 950                 955                 960 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
                965                 970                 975     


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
            980                 985                 990         


Glu Leu Met Gln Ala Leu Asn Phe  Asn Ser Glu Thr Val  Pro Gln Lys 
        995                 1000                 1005             


Ser Ser  Leu Glu Glu Pro Asp  Phe Tyr Lys Thr Lys  Ile Lys Leu 
    1010                 1015                 1020             


Cys Ile  Leu Leu His Ala Phe  Arg Ile Arg Ala Val  Thr Ile Asp 
    1025                 1030                 1035             


Arg Val  Met Ser Tyr Leu Asn  Ala Ser Gly Ser Val  Gly Ser Leu 
    1040                 1045                 1050             


Asn Cys  Ile Val Ala Val Ser  Gln Asn Met Gly Ile  Gly Lys Asn 
    1055                 1060                 1065             


Gly Asp  Leu Pro Trp Pro Pro  Leu Arg Asn Glu Phe  Arg Tyr Phe 
    1070                 1075                 1080             


Gln Arg  Met Thr Thr Thr Ser  Ser Val Glu Gly Lys  Gln Asn Leu 
    1085                 1090                 1095             


Val Ile  Met Gly Lys Lys Thr  Trp Phe Ser Ile Pro  Glu Lys Asn 
    1100                 1105                 1110             


Arg Pro  Leu Lys Gly Arg Ile  Asn Leu Val Leu Ser  Arg Glu Leu 
    1115                 1120                 1125             


Lys Glu  Pro Pro Gln Gly Ala  His Phe Leu Ser Arg  Ser Leu Asp 
    1130                 1135                 1140             


Asp Ala  Leu Lys Leu Thr Glu  Gln Pro Glu Leu Ala  Asn Lys Val 
    1145                 1150                 1155             


Asp Met  Val Trp Ile Val Gly  Gly Ser Ser Val Ile  Lys Glu Ala 
    1160                 1165                 1170             


Met Tyr  His Pro Gly His Leu  Lys Leu Phe Val Thr  Arg Ile Met 
    1175                 1180                 1185             


Gln Asp  Phe Glu Ser Asp Thr  Phe Phe Pro Glu Ile  Asp Leu Glu 
    1190                 1195                 1200             


Lys Tyr  Lys Leu Leu Pro Glu  Tyr Pro Gly Val Leu  Ser Asp Val 
    1205                 1210                 1215             


Gln Glu  Glu Lys Gly Ile Lys  Tyr Lys Phe Glu Val  Tyr Glu Lys 
    1220                 1225                 1230             


Asn Asp  
    1235 


<210>  1128
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1128

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1129
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1129

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Ser 
    530                 535                 540         


<210>  1130
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1130

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1131
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1131

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Tyr His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1132
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1132

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1133
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1133

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Val Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1134
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1134

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1135
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1135

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1136
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1136

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1137
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1137

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Ala Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1138
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1138

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1139
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1139

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Val Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1140
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1140

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1141
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1141

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
545                 550                 555                 560 


Ala Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
                565                 570                 575     


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
            580                 585                 590         


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
        595                 600                 605             


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
    610                 615                 620                 


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
625                 630                 635                 640 


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
                645                 650                 655     


Val Trp Ile Val Gly Gly Ser Ser Val Ile Lys Glu Ala Met Asn His 
            660                 665                 670         


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
        675                 680                 685             


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
    690                 695                 700                 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
705                 710                 715                 720 


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
                725                 730     


<210>  1142
<211>  903
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1142

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Trp Thr 
            500                 505                 510         


Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Asn Trp 
        515                 520                 525             


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
    530                 535                 540                 


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
545                 550                 555                 560 


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
                565                 570                 575     


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
            580                 585                 590         


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
        595                 600                 605             


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu 
    610                 615                 620                 


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr Cys Pro Pro Pro 
            660                 665                 670         


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
        675                 680                 685             


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
    690                 695                 700                 


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
705                 710                 715                 720 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
                725                 730                 735     


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
            740                 745                 750         


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
        755                 760                 765             


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
    770                 775                 780                 


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
785                 790                 795                 800 


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
                805                 810                 815     


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
            820                 825                 830         


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
        835                 840                 845             


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
    850                 855                 860                 


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
865                 870                 875                 880 


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
                885                 890                 895     


Glu Asn Cys Ser His His Leu 
            900             


<210>  1143
<211>  4276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1143
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagttgg     3720

ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc atcggcaaga acggggacct     3780

gccctggcca ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc     3840

agtagaaggt aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga     3900

gaagaatcga cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc     3960

tccacaagga gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca     4020

accagaatta gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgttattaa     4080

ggaagccatg tatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt     4140

tgaaagtgac acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata     4200

cccaggtgtt ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata     4260

tgagaagaat gattaa                                                     4276


<210>  1144
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1144
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1145
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1145
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc     1680

atcggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag     1740

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag     1800

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc     1860

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat     1920

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt     1980

ggtggcagtt ctgttattaa ggaagccatg tatcacccag gccatcttaa actatttgtg     2040

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa     2100

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt     2160

aagtacaaat ttgaagtata tgagaagaat gattaa                               2196


<210>  1146
<211>  4189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1146
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggatccagcg gcatctctct     3720

gattgcggcg ctggcagttg actacgttat tggcatggaa aacgcgatgc catggaacct     3780

cccggctgac ctggcgtggt tcaaacgtaa caccctgaac aaacctgtga tcatgggtcg     3840

tcacacctgg gaatctattg gccgtcctct cccgggtcgt aaaaacatca ttctgtcttc     3900

tcagccaggc accgacgacc gtgttacctg ggttaaaagc gttgacgaag cgattgctgc     3960

gtgcggtgat gttcctgaaa ttatggtgat cggcggtggc cgtgttatcg aacagttcct     4020

gccgaaagcg cagaaactgt acctgaccca catcgacgcg gaagttgaag gtgacaccca     4080

cttcccggac tacgaaccgg atgattggga gagcgtattc tccgaattcc atgatgcgga     4140

tgcgcaaaac tctcattctt actgttttga aatcctggaa cgtcgttaa                 4189


<210>  1147
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1147
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1148
<211>  2109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1148
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggatccagcg gcatctctct gattgcggcg ctggcagttg actacgttat tggcatggaa     1680

aacgcgatgc catggaacct cccggctgac ctggcgtggt tcaaacgtaa caccctgaac     1740

aaacctgtga tcatgggtcg tcacacctgg gaatctattg gccgtcctct cccgggtcgt     1800

aaaaacatca ttctgtcttc tcagccaggc accgacgacc gtgttacctg ggttaaaagc     1860

gttgacgaag cgattgctgc gtgcggtgat gttcctgaaa ttatggtgat cggcggtggc     1920

cgtgttatcg aacagttcct gccgaaagcg cagaaactgt acctgaccca catcgacgcg     1980

gaagttgaag gtgacaccca cttcccggac tacgaaccgg atgattggga gagcgtattc     2040

tccgaattcc atgatgcgga tgcgcaaaac tctcattctt actgttttga aatcctggaa     2100

cgtcgttaa                                                             2109


<210>  1149
<211>  3630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1149
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atcagctact aacttcagcc tgctgaagca ggctggagac     1500

gtggaggaga accctggacc tatgtgccac caacagctcg tgatcagctg gttctccctg     1560

gtgttcctgg ctagccccct ggtggccatc tgggagctca agaaagacgt gtacgtggtg     1620

gaactggact ggtaccccga cgcccctggc gaaatggtgg tgctgacatg cgacacccct     1680

gaggaggatg gcattacctg gaccctcgat cagagctccg aggtgctggg cagcggcaaa     1740

accctgacca tccaggtgaa ggagtttggc gatgccggcc agtacacatg tcacaagggc     1800

ggcgaggtgc tgagccactc cctgctgctg ctccacaaga aggaagatgg catctggagc     1860

accgacattc tgaaggatca gaaggagccc aagaacaaga cattcctgag gtgtgaggcc     1920

aagaactaca gcggcaggtt tacctgctgg tggctgacaa caatcagcac cgacctcaca     1980

ttctccgtca agtcctccag gggttcttcc gaccctcaag gcgtgacatg cggcgctgcc     2040

accctgagcg ctgagagagt caggggcgac aacaaggagt acgagtacag cgtcgaatgt     2100

caggaggaca gcgcctgtcc cgccgctgaa gagagcctgc ctatcgaggt gatggtggac     2160

gccgtgcaca aactgaagta tgagaattac acctccagct tcttcatcag ggacatcatc     2220

aaacccgatc cccccaagaa cctgcagctg aagcctctga agaacagcag acaggtcgaa     2280

gtgtcctggg agtaccctga tacctggtcc acaccccaca gctacttcag cctgaccttt     2340

tgcgtgcagg tgcagggcaa gagcaaaagg gagaagaagg acagggtgtt taccgacaag     2400

acctccgcca cagtgatttg cagaaagaac gcctccatca gcgtgagggc ccaggacagg     2460

tattacagca gctcctggag cgaatgggct agcgtgccct gtagcggagg aggaggcagc     2520

ggaggaggag gttctggagg aggcggcagc agaaacctgc ctgtcgctac ccccgacccc     2580

ggaatgttcc cctgcctgca ccactcccag aacctcctga gggccgtgtc caacatgctg     2640

cagaaggcta gacagaccct cgaattctac ccctgtacca gcgaggagat cgaccatgag     2700

gacatcacca aggataagac cagcaccgtg gaggcttgcc tgcctctgga gctgaccaaa     2760

aacgagagct gcctgaacag cagggaaacc agcttcatta ccaacggctc ctgcctggcc     2820

tccaggaaga catccttcat gatggccctg tgcctcagca gcatctacga ggacctgaag     2880

atgtatcagg tggagtttaa gaccatgaat gccaagctgc tgatggaccc taagaggcag     2940

atcttcctgg accagaatat gctggccgtg attgacgagc tgatgcaggc cctcaacttt     3000

aacagcgaga ccgtgcccca gaaaagcagc ctcgaagagc ctgacttcta caaaaccaag     3060

attaagctgt gtatcctgct gcacgccttc aggatcaggg ccgtgaccat cgacagggtg     3120

atgagctacc tgaacgccag cggatcctca gggatctcac ttatcgcagc cttggcagtt     3180

gattatgtga tcggcatgga aaatgcgatg ccatggaatc ttccggccga cctcgcttgg     3240

ttcaaacgca acaccctgaa caaacccgtt attatgggcc gacatacatg ggaaagtatc     3300

ggcaggccat tgcccggtcg gaaaaacata atcctttcct cccagccggg cacggacgat     3360

agagtgactt gggtcaaatc agttgacgag gccattgctg cctgcggcga tgtacccgag     3420

attatggtta tcggaggggg gcgagttatt gagcagtttc tgcccaaagc gcagaagttg     3480

taccttactc atatagatgc agaggtagag ggcgacacgc atttccccga ctacgaaccg     3540

gatgattggg aatccgtatt ttccgaattc cacgacgcgg atgcccaaaa cagtcactct     3600

tactgttttg aaattcttga gcgacgctga                                      3630


<210>  1150
<211>  3708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1150
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atcagctact aacttcagcc tgctgaagca ggctggagac     1500

gtggaggaga accctggacc tatgtgccac caacagctcg tgatcagctg gttctccctg     1560

gtgttcctgg ctagccccct ggtggccatc tgggagctca agaaagacgt gtacgtggtg     1620

gaactggact ggtaccccga cgcccctggc gaaatggtgg tgctgacatg cgacacccct     1680

gaggaggatg gcattacctg gaccctcgat cagagctccg aggtgctggg cagcggcaaa     1740

accctgacca tccaggtgaa ggagtttggc gatgccggcc agtacacatg tcacaagggc     1800

ggcgaggtgc tgagccactc cctgctgctg ctccacaaga aggaagatgg catctggagc     1860

accgacattc tgaaggatca gaaggagccc aagaacaaga cattcctgag gtgtgaggcc     1920

aagaactaca gcggcaggtt tacctgctgg tggctgacaa caatcagcac cgacctcaca     1980

ttctccgtca agtcctccag gggttcttcc gaccctcaag gcgtgacatg cggcgctgcc     2040

accctgagcg ctgagagagt caggggcgac aacaaggagt acgagtacag cgtcgaatgt     2100

caggaggaca gcgcctgtcc cgccgctgaa gagagcctgc ctatcgaggt gatggtggac     2160

gccgtgcaca aactgaagta tgagaattac acctccagct tcttcatcag ggacatcatc     2220

aaacccgatc cccccaagaa cctgcagctg aagcctctga agaacagcag acaggtcgaa     2280

gtgtcctggg agtaccctga tacctggtcc acaccccaca gctacttcag cctgaccttt     2340

tgcgtgcagg tgcagggcaa gagcaaaagg gagaagaagg acagggtgtt taccgacaag     2400

acctccgcca cagtgatttg cagaaagaac gcctccatca gcgtgagggc ccaggacagg     2460

tattacagca gctcctggag cgaatgggct agcgtgccct gtagcggagg aggaggcagc     2520

ggaggaggag gttctggagg aggcggcagc agaaacctgc ctgtcgctac ccccgacccc     2580

ggaatgttcc cctgcctgca ccactcccag aacctcctga gggccgtgtc caacatgctg     2640

cagaaggcta gacagaccct cgaattctac ccctgtacca gcgaggagat cgaccatgag     2700

gacatcacca aggataagac cagcaccgtg gaggcttgcc tgcctctgga gctgaccaaa     2760

aacgagagct gcctgaacag cagggaaacc agcttcatta ccaacggctc ctgcctggcc     2820

tccaggaaga catccttcat gatggccctg tgcctcagca gcatctacga ggacctgaag     2880

atgtatcagg tggagtttaa gaccatgaat gccaagctgc tgatggaccc taagaggcag     2940

atcttcctgg accagaatat gctggccgtg attgacgagc tgatgcaggc cctcaacttt     3000

aacagcgaga ccgtgcccca gaaaagcagc ctcgaagagc ctgacttcta caaaaccaag     3060

attaagctgt gtatcctgct gcacgccttc aggatcaggg ccgtgaccat cgacagggtg     3120

atgagctacc tgaacgccag cggatccgtt ggttcgctaa actgcatcgt cgctgtgtcc     3180

cagaacatgg gcgtcggcaa gaacggggac ctgccctggc caccgctcag gaatgaattc     3240

agatatttcc agagaatgac cacaacctct tcagtagaag gtaaacagaa tctggtgatt     3300

atgggtaaga agacctggtt ctccattcct gagaagaatc gacctttaaa gggtagaatt     3360

aatttagttc tcagcagaga actcaaggaa cctccacaag gagctcattt tctttccaga     3420

agtctagatg atgccttaaa acttactgaa caaccagaat tagcaaataa agtagacatg     3480

gtctggatag ttggtggcag ttctgtttat aaggaagcca tgaatcaccc aggccatctt     3540

aaactatttg tgacaaggat catgcaagac tttgaaagtg acacgttttt tccagaaatt     3600

gatttggaga aatataaact tctgccagaa tacccaggtg ttctctctga tgtccaggag     3660

gagaaaggca ttaagtacaa atttgaagta tatgagaaga atgattaa                  3708


<210>  1151
<211>  3708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1151
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atcagctact aacttcagcc tgctgaagca ggctggagac     1500

gtggaggaga accctggacc tatgtgccac caacagctcg tgatcagctg gttctccctg     1560

gtgttcctgg ctagccccct ggtggccatc tgggagctca agaaagacgt gtacgtggtg     1620

gaactggact ggtaccccga cgcccctggc gaaatggtgg tgctgacatg cgacacccct     1680

gaggaggatg gcattacctg gaccctcgat cagagctccg aggtgctggg cagcggcaaa     1740

accctgacca tccaggtgaa ggagtttggc gatgccggcc agtacacatg tcacaagggc     1800

ggcgaggtgc tgagccactc cctgctgctg ctccacaaga aggaagatgg catctggagc     1860

accgacattc tgaaggatca gaaggagccc aagaacaaga cattcctgag gtgtgaggcc     1920

aagaactaca gcggcaggtt tacctgctgg tggctgacaa caatcagcac cgacctcaca     1980

ttctccgtca agtcctccag gggttcttcc gaccctcaag gcgtgacatg cggcgctgcc     2040

accctgagcg ctgagagagt caggggcgac aacaaggagt acgagtacag cgtcgaatgt     2100

caggaggaca gcgcctgtcc cgccgctgaa gagagcctgc ctatcgaggt gatggtggac     2160

gccgtgcaca aactgaagta tgagaattac acctccagct tcttcatcag ggacatcatc     2220

aaacccgatc cccccaagaa cctgcagctg aagcctctga agaacagcag acaggtcgaa     2280

gtgtcctggg agtaccctga tacctggtcc acaccccaca gctacttcag cctgaccttt     2340

tgcgtgcagg tgcagggcaa gagcaaaagg gagaagaagg acagggtgtt taccgacaag     2400

acctccgcca cagtgatttg cagaaagaac gcctccatca gcgtgagggc ccaggacagg     2460

tattacagca gctcctggag cgaatgggct agcgtgccct gtagcggagg aggaggcagc     2520

ggaggaggag gttctggagg aggcggcagc agaaacctgc ctgtcgctac ccccgacccc     2580

ggaatgttcc cctgcctgca ccactcccag aacctcctga gggccgtgtc caacatgctg     2640

cagaaggcta gacagaccct cgaattctac ccctgtacca gcgaggagat cgaccatgag     2700

gacatcacca aggataagac cagcaccgtg gaggcttgcc tgcctctgga gctgaccaaa     2760

aacgagagct gcctgaacag cagggaaacc agcttcatta ccaacggctc ctgcctggcc     2820

tccaggaaga catccttcat gatggccctg tgcctcagca gcatctacga ggacctgaag     2880

atgtatcagg tggagtttaa gaccatgaat gccaagctgc tgatggaccc taagaggcag     2940

atcttcctgg accagaatat gctggccgtg attgacgagc tgatgcaggc cctcaacttt     3000

aacagcgaga ccgtgcccca gaaaagcagc ctcgaagagc ctgacttcta caaaaccaag     3060

attaagctgt gtatcctgct gcacgccttc aggatcaggg ccgtgaccat cgacagggtg     3120

atgagctacc tgaacgccag cggatccgtt ggttcgctaa actgcatcgt cgctgtgtcc     3180

cagaacatgg gcgtcggcaa gaacggggac ctgccctggc caccgctcag gaatgaattc     3240

agatatttcc agagaatgac cacaacctct tcagtagaag gtaaacagaa tctggtgatt     3300

atgggtaaga agacctggtt ctccattcct gagaagaatc gacctttaaa gggtagaatt     3360

aatttagttc tcagcagaga actcaaggaa cctccacaag gagctcattt tctttccaga     3420

agtctagatg atgccttaaa acttactgaa caaccagaat tagcaaataa agtagacatg     3480

gtctggatag ttggtggcag ttctgttatt aaggaagcca tgaatcaccc aggccatctt     3540

aaactatttg tgacaaggat catgcaagac tttgaaagtg acacgttttt tccagaaatt     3600

gatttggaga aatataaact tctgccagaa tacccaggtg ttctctctga tgtccaggag     3660

gagaaaggca ttaagtacaa atttgaagta tatgagaaga atgattaa                  3708


<210>  1152
<211>  3708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1152
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atcagctact aacttcagcc tgctgaagca ggctggagac     1500

gtggaggaga accctggacc tatgtgccac caacagctcg tgatcagctg gttctccctg     1560

gtgttcctgg ctagccccct ggtggccatc tgggagctca agaaagacgt gtacgtggtg     1620

gaactggact ggtaccccga cgcccctggc gaaatggtgg tgctgacatg cgacacccct     1680

gaggaggatg gcattacctg gaccctcgat cagagctccg aggtgctggg cagcggcaaa     1740

accctgacca tccaggtgaa ggagtttggc gatgccggcc agtacacatg tcacaagggc     1800

ggcgaggtgc tgagccactc cctgctgctg ctccacaaga aggaagatgg catctggagc     1860

accgacattc tgaaggatca gaaggagccc aagaacaaga cattcctgag gtgtgaggcc     1920

aagaactaca gcggcaggtt tacctgctgg tggctgacaa caatcagcac cgacctcaca     1980

ttctccgtca agtcctccag gggttcttcc gaccctcaag gcgtgacatg cggcgctgcc     2040

accctgagcg ctgagagagt caggggcgac aacaaggagt acgagtacag cgtcgaatgt     2100

caggaggaca gcgcctgtcc cgccgctgaa gagagcctgc ctatcgaggt gatggtggac     2160

gccgtgcaca aactgaagta tgagaattac acctccagct tcttcatcag ggacatcatc     2220

aaacccgatc cccccaagaa cctgcagctg aagcctctga agaacagcag acaggtcgaa     2280

gtgtcctggg agtaccctga tacctggtcc acaccccaca gctacttcag cctgaccttt     2340

tgcgtgcagg tgcagggcaa gagcaaaagg gagaagaagg acagggtgtt taccgacaag     2400

acctccgcca cagtgatttg cagaaagaac gcctccatca gcgtgagggc ccaggacagg     2460

tattacagca gctcctggag cgaatgggct agcgtgccct gtagcggagg aggaggcagc     2520

ggaggaggag gttctggagg aggcggcagc agaaacctgc ctgtcgctac ccccgacccc     2580

ggaatgttcc cctgcctgca ccactcccag aacctcctga gggccgtgtc caacatgctg     2640

cagaaggcta gacagaccct cgaattctac ccctgtacca gcgaggagat cgaccatgag     2700

gacatcacca aggataagac cagcaccgtg gaggcttgcc tgcctctgga gctgaccaaa     2760

aacgagagct gcctgaacag cagggaaacc agcttcatta ccaacggctc ctgcctggcc     2820

tccaggaaga catccttcat gatggccctg tgcctcagca gcatctacga ggacctgaag     2880

atgtatcagg tggagtttaa gaccatgaat gccaagctgc tgatggaccc taagaggcag     2940

atcttcctgg accagaatat gctggccgtg attgacgagc tgatgcaggc cctcaacttt     3000

aacagcgaga ccgtgcccca gaaaagcagc ctcgaagagc ctgacttcta caaaaccaag     3060

attaagctgt gtatcctgct gcacgccttc aggatcaggg ccgtgaccat cgacagggtg     3120

atgagctacc tgaacgccag cggatccgtt ggttcgctaa actgcatcgt cgctgtgtcc     3180

cagaacatgg gcatcggcaa gaacggggac ctgccctggc caccgctcag gaatgaattc     3240

agatatttcc agagaatgac cacaacctct tcagtagaag gtaaacagaa tctggtgatt     3300

atgggtaaga agacctggtt ctccattcct gagaagaatc gacctttaaa gggtagaatt     3360

aatttagttc tcagcagaga actcaaggaa cctccacaag gagctcattt tctttccaga     3420

agtctagatg atgccttaaa acttactgaa caaccagaat tagcaaataa agtagacatg     3480

gtctggatag ttggtggcag ttctgttatt aaggaagcca tgtatcaccc aggccatctt     3540

aaactatttg tgacaaggat catgcaagac tttgaaagtg acacgttttt tccagaaatt     3600

gatttggaga aatataaact tctgccagaa tacccaggtg ttctctctga tgtccaggag     3660

gagaaaggca ttaagtacaa atttgaagta tatgagaaga atgattaa                  3708


<210>  1153
<211>  4276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1153
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagttgg     3720

ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct     3780

gccctggcca ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc     3840

agtagaaggt aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga     3900

gaagaatcga cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc     3960

tccacaagga gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca     4020

accagaatta gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa     4080

ggaagccatg aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt     4140

tgaaagtgac acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata     4200

cccaggtgtt ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata     4260

tgagaagaat gattaa                                                     4276


<210>  1154
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1154
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1155
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1155
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc     1680

gtcggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag     1740

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag     1800

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc     1860

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat     1920

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt     1980

ggtggcagtt ctgtttataa ggaagccatg aatcacccag gccatcttaa actatttgtg     2040

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa     2100

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt     2160

aagtacaaat ttgaagtata tgagaagaat gattaa                               2196


<210>  1156
<211>  4276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1156
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagttgg     3720

ttcgctaaac tgcatcgtgg ccgtgagcca gaacatgggc atcggcaaga atggcgacct     3780

gccttggcca cctctgagga acgagttcag atactttcag aggatgacca caaccagctc     3840

cgtggagggc aagcagaacc tggtcatcat gggcaagaag acatggttct ctatccccga     3900

gaagaaccgc cctctgaagg gccggatcaa tctggtgctg agcagagagc tgaaggagcc     3960

accacaggga gcacacttcc tgagccggag cctggacgat gccctgaagc tgaccgagca     4020

gcccgagctg gccaacaagg tggacatggt gtggatcgtg ggcggctcta gcgtgatcaa     4080

ggaggccatg aatcacccag gccacctgaa gctgttcgtg acaagaatca tgcaggactt     4140

tgagtccgat accttctttc ccgagatcga cctggagaag tacaagctgc tgcctgagta     4200

tccaggcgtg ctgtctgatg tgcaggagga gaagggcatc aagtacaagt tcgaggtgta     4260

tgagaagaat gattaa                                                     4276


<210>  1157
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1157
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1158
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1158
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagttgg ttcgctaaac tgcatcgtgg ccgtgagcca gaacatgggc     1680

atcggcaaga atggcgacct gccttggcca cctctgagga acgagttcag atactttcag     1740

aggatgacca caaccagctc cgtggagggc aagcagaacc tggtcatcat gggcaagaag     1800

acatggttct ctatccccga gaagaaccgc cctctgaagg gccggatcaa tctggtgctg     1860

agcagagagc tgaaggagcc accacaggga gcacacttcc tgagccggag cctggacgat     1920

gccctgaagc tgaccgagca gcccgagctg gccaacaagg tggacatggt gtggatcgtg     1980

ggcggctcta gcgtgatcaa ggaggccatg aatcacccag gccacctgaa gctgttcgtg     2040

acaagaatca tgcaggactt tgagtccgat accttctttc ccgagatcga cctggagaag     2100

tacaagctgc tgcctgagta tccaggcgtg ctgtctgatg tgcaggagga gaagggcatc     2160

aagtacaagt tcgaggtgta tgagaagaat gattaa                               2196


<210>  1159
<211>  4276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1159
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagttgg     3720

ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc gccggcaaga acggggacct     3780

gccctggcca ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc     3840

agtagaaggt aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga     3900

gaagaatcga cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc     3960

tccacaagga gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca     4020

accagaatta gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgtttataa     4080

ggaagccatg aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt     4140

tgaaagtgac acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata     4200

cccaggtgtt ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata     4260

tgagaagaat gattaa                                                     4276


<210>  1160
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1160
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1161
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1161
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc     1680

gccggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag     1740

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag     1800

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc     1860

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat     1920

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt     1980

ggtggcagtt ctgtttataa ggaagccatg aatcacccag gccatcttaa actatttgtg     2040

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa     2100

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt     2160

aagtacaaat ttgaagtata tgagaagaat gattaa                               2196


<210>  1162
<211>  4276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1162
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagttgg     3720

ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc gtcggcaaga acggggacct     3780

gccctggcca ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc     3840

agtagaaggt aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga     3900

gaagaatcga cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc     3960

tccacaagga gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca     4020

accagaatta gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgttattaa     4080

ggaagccatg aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt     4140

tgaaagtgac acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata     4200

cccaggtgtt ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata     4260

tgagaagaat gattaa                                                     4276


<210>  1163
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1163
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1164
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1164
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc     1680

gtcggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag     1740

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag     1800

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc     1860

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat     1920

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt     1980

ggtggcagtt ctgttattaa ggaagccatg aatcacccag gccatcttaa actatttgtg     2040

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa     2100

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt     2160

aagtacaaat ttgaagtata tgagaagaat gattaa                               2196


<210>  1165
<211>  4276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1165
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta aatcgggcta gccgcccctc tccctccccc ccccctaacg     1500

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     1560

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     1620

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     1680

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     1740

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     1800

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     1860

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     1920

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     1980

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     2040

gatgataagc ttgccacaac ccacaaggag acgaccttcc atgtgccacc aacagctcgt     2100

gatcagctgg ttctccctgg tgttcctggc tagccccctg gtggccatct gggagctcaa     2160

gaaagacgtg tacgtggtgg aactggactg gtaccccgac gcccctggcg aaatggtggt     2220

gctgacatgc gacacccctg aggaggatgg cattacctgg accctcgatc agagctccga     2280

ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag gagtttggcg atgccggcca     2340

gtacacatgt cacaagggcg gcgaggtgct gagccactcc ctgctgctgc tccacaagaa     2400

ggaagatggc atctggagca ccgacattct gaaggatcag aaggagccca agaacaagac     2460

attcctgagg tgtgaggcca agaactacag cggcaggttt acctgctggt ggctgacaac     2520

aatcagcacc gacctcacat tctccgtcaa gtcctccagg ggttcttccg accctcaagg     2580

cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc aggggcgaca acaaggagta     2640

cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc gccgctgaag agagcctgcc     2700

tatcgaggtg atggtggacg ccgtgcacaa actgaagtat gagaattaca cctccagctt     2760

cttcatcagg gacatcatca aacccgatcc ccccaagaac ctgcagctga agcctctgaa     2820

gaacagcaga caggtcgaag tgtcctggga gtaccctgat acctggtcca caccccacag     2880

ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag agcaaaaggg agaagaagga     2940

cagggtgttt accgacaaga cctccgccac agtgatttgc agaaagaacg cctccatcag     3000

cgtgagggcc caggacaggt attacagcag ctcctggagc gaatgggcta gcgtgccctg     3060

tagcggagga ggaggcagcg gaggaggagg ttctggagga ggcggcagca gaaacctgcc     3120

tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac cactcccaga acctcctgag     3180

ggccgtgtcc aacatgctgc agaaggctag acagaccctc gaattctacc cctgtaccag     3240

cgaggagatc gaccatgagg acatcaccaa ggataagacc agcaccgtgg aggcttgcct     3300

gcctctggag ctgaccaaaa acgagagctg cctgaacagc agggaaacca gcttcattac     3360

caacggctcc tgcctggcct ccaggaagac atccttcatg atggccctgt gcctcagcag     3420

catctacgag gacctgaaga tgtatcaggt ggagtttaag accatgaatg ccaagctgct     3480

gatggaccct aagaggcaga tcttcctgga ccagaatatg ctggccgtga ttgacgagct     3540

gatgcaggcc ctcaacttta acagcgagac cgtgccccag aaaagcagcc tcgaagagcc     3600

tgacttctac aaaaccaaga ttaagctgtg tatcctgctg cacgccttca ggatcagggc     3660

cgtgaccatc gacagggtga tgagctacct gaacgccagc ggtggatccg gaggagttgg     3720

ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc gccggcaaga acggggacct     3780

gccctggcca ccgctcagga atgaattcag atatttccag agaatgacca caacctcttc     3840

agtagaaggt aaacagaatc tggtgattat gggtaagaag acctggttct ccattcctga     3900

gaagaatcga cctttaaagg gtagaattaa tttagttctc agcagagaac tcaaggaacc     3960

tccacaagga gctcattttc tttccagaag tctagatgat gccttaaaac ttactgaaca     4020

accagaatta gcaaataaag tagacatggt ctggatagtt ggtggcagtt ctgttattaa     4080

ggaagccatg aatcacccag gccatcttaa actatttgtg acaaggatca tgcaagactt     4140

tgaaagtgac acgttttttc cagaaattga tttggagaaa tataaacttc tgccagaata     4200

cccaggtgtt ctctctgatg tccaggagga gaaaggcatt aagtacaaat ttgaagtata     4260

tgagaagaat gattaa                                                     4276


<210>  1166
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1166
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1167
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1167
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg gaggagttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc     1680

gccggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag     1740

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag     1800

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc     1860

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat     1920

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt     1980

ggtggcagtt ctgttattaa ggaagccatg aatcacccag gccatcttaa actatttgtg     2040

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa     2100

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt     2160

aagtacaaat ttgaagtata tgagaagaat gattaa                               2196


<210>  1168
<211>  2712
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1168
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atccggagct actaacttca gcctgctgaa gcaggctgga     1500

gacgtggagg agaaccctgg acctatggac tggacctgga ttctgtttct ggtggccgct     1560

gccacaagag tgcacagcaa ttgggtcaac gtgatcagcg acctgaagaa gatcgaggac     1620

ctgatccaga gcatgcacat cgacgccaca ctgtacaccg agtccgatgt gcaccctagc     1680

tgcaaagtga ccgccatgaa gtgctttctg ctggaactgc aagtgatcag cctggaaagc     1740

ggcgacgcca gcatccacga taccgtggaa aatctgatca tcctggccaa caacagcctg     1800

agcagcaacg gcaatgtgac cgagagcggc tgcaaagagt gcgaggaact ggaagagaag     1860

aacatcaaag agttcctcca gagcttcgtc cacatcgtgc agatgttcat caacaccagc     1920

tctggcggag gaagcggagg cggaggatct ggtggtggtg gatctggcgg cggtggtagt     1980

ggcggaggtt ctctgcaaat cacctgtcct ccacctatga gcgtggaaca cgccgacatc     2040

tgggtcaaga gctacagcct gtacagcaga gagcggtaca tctgcaacag cggcttcaag     2100

agaaaggccg gcacaagcag cctgaccgag tgtgtgctga acaaggccac aaacgtggcc     2160

cactggacca cacctagcct gaagtgcatc agagatcccg ctctggttca ccagaggcct     2220

gctcctccat ctacagtgac aacagctggc gtgacccctc agcctgagtc tctgtctcca     2280

tctggaaaag agcctgccgc cagctctccc agctctaaca atactgctgc caccacagcc     2340

gccatcgtgc ctggatctca gctgatgcct agcaagagcc ctagcaccgg cacaacagag     2400

atcagctctc acgagtctag ccacggcacc ccatctcaga ccacagccaa gaattgggag     2460

ctgaccgcct ctgcctctca tcagccacct ggtgtttacc ctcaaggcca ctctgatacc     2520

accgtggcca tcagcacaag cacagtgctg ctgtgtggac tgtctgccgt gtctctgctg     2580

gcctgctacc tgaagtctag acagacacct cctctggcca gcgtggaaat ggaagccatg     2640

gaagctctgc ctgtgacatg gggcaccagc agcagagatg aggacctcga gaattgcagc     2700

caccacctgt ag                                                         2712


<210>  1169
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1169

Gln Val Gln Leu Leu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr 
        115                 


<210>  1170
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1170

Glu Leu Val Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Ser Ala Thr Tyr Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Lys Asp Leu Ala Asp Tyr Phe Tyr Phe Cys Gln Tyr Asn Arg Tyr Pro 
                85                  90                  95      


Tyr Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Arg Ser 
            100                 105                 110     


<210>  1171
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1171

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  1172
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1172

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  1173
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1173

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  1174
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1174

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  1175
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1175

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  1176
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1176

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  1177
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1177
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  1178
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1178
aagcgcggtc ggaagaagct gctgtacatc tttaagcaac ccttcatgag gcctgtgcag       60

actactcaag aggaggacgg ctgttcatgc cggttcccag aggaggagga aggcggctgc      120

gaactg                                                                 126


<210>  1179
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1179
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1180
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1180
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  1181
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1181
cgcgtgaaat tcagccgcag cgcagatgct ccagcctaca agcaggggca gaaccagctc       60

tacaacgaac tcaatcttgg tcggagagag gagtacgacg tgctggacaa gcggagagga      120

cgggacccag aaatgggcgg gaagccgcgc agaaagaatc cccaagaggg cctgtacaac      180

gagctccaaa aggataagat ggcagaagcc tatagcgaga ttggtatgaa aggggaacgc      240

agaagaggca aaggccacga cggactgtac cagggactca gcaccgccac caaggacacc      300

tatgacgctc ttcacatgca ggccctgccg cctcgg                                336


<210>  1182
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1182
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  1183
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1183
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga cccta                      105


<210>  1184
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1184
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  1185
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1185

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  1186
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  1186
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  1187
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  1187
atctacattt gggcccctct ggctggtact tgcggggtcc tgctgctttc actcgtgatc       60

actctttact gt                                                           72


<210>  1188
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1188

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Leu 
        35                  40                  45              


Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile 
    50                  55                  60                  


Leu Ile Cys Trp Leu 
65                  


<210>  1189
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1189
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatttctg gttacccata ggatgtgcag cctttgttgt agtctgcatt      180

ttgggatgca tacttatttg ttggctt                                          207


<210>  1190
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1190

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  1191
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1191
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  1192
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1192

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  1193
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1193
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag      360

gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaagatg                                       690


<210>  1194
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1194

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  1195
<211>  847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  1195
aggtggcccg aaagtcccaa ggcccaggca tctagtgttc ctactgcaca gccccaggca       60

gaaggcagcc tagccaaagc tactactgca cctgccacta cgcgcaatac tggccgtggc      120

ggggaggaga agaaaaagga gaaagagaaa gaagaacagg aagagaggga gaccaagacc      180

cctgaatgtc catcccatac ccagccgctg ggcgtctatc tcttgactcc cgcagtacag      240

gacttgtggc ttagagataa ggccaccttt acatgtttcg tcgtgggctc tgacctgaag      300

gatgcccatt tgacttggga ggttgccgga aaggtaccca cagggggggt tgaggaaggg      360

ttgctggagc gccattccaa tggctctcag agccagcact caagactcac ccttccgaga      420

tccctgtgga acgccgggac ctctgtcaca tgtactctaa atcatcctag cctgccccca      480

cagcgtctga tggcccttag agagccagcc gcccaggcac cagttaagct tagcctgaat      540

ctgctcgcca gtagtgatcc cccagaggcc gccagctggc tcttatgcga agtgtccggc      600

tttagcccgc ccaacatctt gctcatgtgg ctggaggacc agcgagaagt gaacaccagc      660

ggcttcgctc cagcccggcc cccaccccag ccgggttcta ccacattctg ggcctggagt      720

gtcttaaggg tcccagcacc acctagcccc cagccagcca catacacctg tgttgtgtcc      780

catgaagata gcaggaccct gctaaatgct tctaggagtc tggaggtttc ctacgtgact      840

gaccatt                                                                847


<210>  1196
<211>  3477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1196
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcgg atcagctact aacttcagcc tgctgaagca ggctggagac     1500

gtggaggaga accctggacc tatgtgccac caacagctcg tgatcagctg gttctccctg     1560

gtgttcctgg ctagccccct ggtggccatc tgggagctca agaaagacgt gtacgtggtg     1620

gaactggact ggtaccccga cgcccctggc gaaatggtgg tgctgacatg cgacacccct     1680

gaggaggatg gcattacctg gaccctcgat cagagctccg aggtgctggg cagcggcaaa     1740

accctgacca tccaggtgaa ggagtttggc gatgccggcc agtacacatg tcacaagggc     1800

ggcgaggtgc tgagccactc cctgctgctg ctccacaaga aggaagatgg catctggagc     1860

accgacattc tgaaggatca gaaggagccc aagaacaaga cattcctgag gtgtgaggcc     1920

aagaactaca gcggcaggtt tacctgctgg tggctgacaa caatcagcac cgacctcaca     1980

ttctccgtca agtcctccag gggttcttcc gaccctcaag gcgtgacatg cggcgctgcc     2040

accctgagcg ctgagagagt caggggcgac aacaaggagt acgagtacag cgtcgaatgt     2100

caggaggaca gcgcctgtcc cgccgctgaa gagagcctgc ctatcgaggt gatggtggac     2160

gccgtgcaca aactgaagta tgagaattac acctccagct tcttcatcag ggacatcatc     2220

aaacccgatc cccccaagaa cctgcagctg aagcctctga agaacagcag acaggtcgaa     2280

gtgtcctggg agtaccctga tacctggtcc acaccccaca gctacttcag cctgaccttt     2340

tgcgtgcagg tgcagggcaa gagcaaaagg gagaagaagg acagggtgtt taccgacaag     2400

acctccgcca cagtgatttg cagaaagaac gcctccatca gcgtgagggc ccaggacagg     2460

tattacagca gctcctggag cgaatgggct agcgtgccct gtagcggagg aggaggcagc     2520

ggaggaggag gttctggagg aggcggcagc agaaacctgc ctgtcgctac ccccgacccc     2580

ggaatgttcc cctgcctgca ccactcccag aacctcctga gggccgtgtc caacatgctg     2640

cagaaggcta gacagaccct cgaattctac ccctgtacca gcgaggagat cgaccatgag     2700

gacatcacca aggataagac cagcaccgtg gaggcttgcc tgcctctgga gctgaccaaa     2760

aacgagagct gcctgaacag cagggaaacc agcttcatta ccaacggctc ctgcctggcc     2820

tccaggaaga catccttcat gatggccctg tgcctcagca gcatctacga ggacctgaag     2880

atgtatcagg tggagtttaa gaccatgaat gccaagctgc tgatggaccc taagaggcag     2940

atcttcctgg accagaatat gctggccgtg attgacgagc tgatgcaggc cctcaacttt     3000

aacagcgaga ccgtgcccca gaaaagcagc ctcgaagagc ctgacttcta caaaaccaag     3060

attaagctgt gtatcctgct gcacgccttc aggatcaggg ccgtgaccat cgacagggtg     3120

atgagctacc tgaacgccag cggtggatcc ggaggagtgc aggtggagac aatcagcccc     3180

ggcgatggca ggacctttcc taagcgcggc cagacatgcg tggtgcacta caccggcatg     3240

ctgggcgacg gcaagaaggt ggacagctcc cgggatagaa ataagccctt caagtttatg     3300

ctgggcaagc aggaagtgat cagaggctgg gaggagggag tggcacagat gtctgtggga     3360

cagggcgcca agctgacaat cagcccagat tacgcatatg gagcaaccgg acacccagga     3420

atcatcccac cccacgccac cctggtgttc gacgtggagc tgctggagct ggagtaa        3477


<210>  1197
<211>  1999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1197
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg agtccaggag agtgcggcgc aacaagagga gcaagggatc ctggaggagt     1680

gcaggtggag acaatcagcc ccggcgatgg caggaccttt cctaagcgcg gccagacatg     1740

cgtggtgcac tacaccggca tgctgggcga cggcaagaag gtggacagct cccgggatag     1800

aaataagccc ttcaagttta tgctgggcaa gcaggaagtg atcagaggct gggaggaggg     1860

agtggcacag atgtctgtgg gacagggcgc caagctgaca atcagcccag attacgcata     1920

tggagcaacc ggacacccag gaatcatccc accccacgcc accctggtgt tcgacgtgga     1980

gctgctggag ctggagtaa                                                  1999


<210>  1198
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1198
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacca agctggagat cacaggtggc ggtggctcgg gcggtggtgg gtcgggtggc      420

ggcggatctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gccaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccttggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcta a                                               1461


<210>  1199
<211>  1999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1199
atgtgccacc aacagctcgt gatcagctgg ttctccctgg tgttcctggc tagccccctg       60

gtggccatct gggagctcaa gaaagacgtg tacgtggtgg aactggactg gtaccccgac      120

gcccctggcg aaatggtggt gctgacatgc gacacccctg aggaggatgg cattacctgg      180

accctcgatc agagctccga ggtgctgggc agcggcaaaa ccctgaccat ccaggtgaag      240

gagtttggcg atgccggcca gtacacatgt cacaagggcg gcgaggtgct gagccactcc      300

ctgctgctgc tccacaagaa ggaagatggc atctggagca ccgacattct gaaggatcag      360

aaggagccca agaacaagac attcctgagg tgtgaggcca agaactacag cggcaggttt      420

acctgctggt ggctgacaac aatcagcacc gacctcacat tctccgtcaa gtcctccagg      480

ggttcttccg accctcaagg cgtgacatgc ggcgctgcca ccctgagcgc tgagagagtc      540

aggggcgaca acaaggagta cgagtacagc gtcgaatgtc aggaggacag cgcctgtccc      600

gccgctgaag agagcctgcc tatcgaggtg atggtggacg ccgtgcacaa actgaagtat      660

gagaattaca cctccagctt cttcatcagg gacatcatca aacccgatcc ccccaagaac      720

ctgcagctga agcctctgaa gaacagcaga caggtcgaag tgtcctggga gtaccctgat      780

acctggtcca caccccacag ctacttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaaaaggg agaagaagga cagggtgttt accgacaaga cctccgccac agtgatttgc      900

agaaagaacg cctccatcag cgtgagggcc caggacaggt attacagcag ctcctggagc      960

gaatgggcta gcgtgccctg tagcggagga ggaggcagcg gaggaggagg ttctggagga     1020

ggcggcagca gaaacctgcc tgtcgctacc cccgaccccg gaatgttccc ctgcctgcac     1080

cactcccaga acctcctgag ggccgtgtcc aacatgctgc agaaggctag acagaccctc     1140

gaattctacc cctgtaccag cgaggagatc gaccatgagg acatcaccaa ggataagacc     1200

agcaccgtgg aggcttgcct gcctctggag ctgaccaaaa acgagagctg cctgaacagc     1260

agggaaacca gcttcattac caacggctcc tgcctggcct ccaggaagac atccttcatg     1320

atggccctgt gcctcagcag catctacgag gacctgaaga tgtatcaggt ggagtttaag     1380

accatgaatg ccaagctgct gatggaccct aagaggcaga tcttcctgga ccagaatatg     1440

ctggccgtga ttgacgagct gatgcaggcc ctcaacttta acagcgagac cgtgccccag     1500

aaaagcagcc tcgaagagcc tgacttctac aaaaccaaga ttaagctgtg tatcctgctg     1560

cacgccttca ggatcagggc cgtgaccatc gacagggtga tgagctacct gaacgccagc     1620

ggtggatccg agtccaggag agtgcggcgc aacaagagga gcaagggatc ctggaggagt     1680

gcaggtggag acaatcagcc ccggcgatgg caggaccttt cctaagcgcg gccagacatg     1740

cgtggtgcac tacaccggca tgctgggcga cggcaagaag gtggacagct cccgggatag     1800

aaataagccc ttcaagttta tgctgggcaa gcaggaagtg atcagaggct gggaggaggg     1860

agtggcacag atgtctgtgg gacagggcgc caagctgaca atcagcccag attacgcata     1920

tggagcaacc ggacacccag gaatcatccc accccacgcc accctggtgt tcgacgtgga     1980

gctgctggag ctggagtaa                                                  1999


<210>  1200
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1200

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  1201
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Construct

<400>  1201

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Ser Glu 
    530                 535                 540                 


Ser Arg Arg Val Arg Arg Asn Lys Arg Ser Lys Gly Ser Trp Gly Val 
545                 550                 555                 560 


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
                565                 570                 575     


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Gly Asp Gly Lys 
            580                 585                 590         


Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
        595                 600                 605             


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
    610                 615                 620                 


Ser Val Gly Gln Gly Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
625                 630                 635                 640 


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
                645                 650                 655     


Phe Asp Val Glu Leu Leu Glu Leu Glu 
            660                 665 


<210>  1202
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  1202
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

ccc                                                                     63


<210>  1203
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide

<400>  1203
atggccctcc ctgtcaccgc cctgctgctt ccgctggctc ttctgctcca cgccgctcgg       60

ccc                                                                     63


<210>  1204
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1204

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  1205
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1205

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  1206
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1206

Met Ala Gln Val Lys Leu Gln Glu Ser Gly Thr Glu Leu Ala Lys Pro 
1               5                   10                  15      


Gly Ala Ala Val Lys 
            20      


<210>  1207
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1207

Met Arg Phe Leu Ala Ala Thr Phe Leu Leu Leu Ala Leu Ser Thr Ala 
1               5                   10                  15      


Ala Gln Ala 
            


<210>  1208
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1208

Met Gly Leu Leu Gln Leu Leu Ala Phe Ser Phe Leu Ala Leu Cys Arg 
1               5                   10                  15      


Ala Arg Val Arg Ala 
            20      


<210>  1209
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1209

Met Leu Leu Ala Trp Val Gln Ala Phe Leu Val Ser Asn Met Leu Leu 
1               5                   10                  15      


Ala Glu Ala Tyr Gly 
            20      


<210>  1210
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1210

Met Lys Phe Gln Gly Pro Leu Ala Cys Leu Leu Leu Ala Leu Cys Leu 
1               5                   10                  15      


Gly Ser Gly Glu Ala 
            20      


<210>  1211
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1211

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro 
            20          


<210>  1212
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1212

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp 
        35  


<210>  1213
<211>  576
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic IRES sequence

<400>  1213
cgcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg       60

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc      120

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa      180

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga      240

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc      300

ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc      360

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac      420

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg      480

tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac      540

ggggacgtgg ttttcctttg aaaaacacga tgataa                                576


<210>  1214
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Payload sequence

<400>  1214
agaaacctgc ctgtcgctac ccccgacccc ggaatgttcc cctgcctgca ccactcccag       60

aacctcctga gggccgtgtc caacatgctg cagaaggcta gacagaccct cgaattctac      120

ccctgtacca gcgaggagat cgaccatgag gacatcacca aggataagac cagcaccgtg      180

gaggcttgcc tgcctctgga gctgaccaaa aacgagagct gcctgaacag cagggaaacc      240

agcttcatta ccaacggctc ctgcctggcc tccaggaaga catccttcat gatggccctg      300

tgcctcagca gcatctacga ggacctgaag atgtatcagg tggagtttaa gaccatgaat      360

gccaagctgc tgatggaccc taagaggcag atcttcctgg accagaatat gctggccgtg      420

attgacgagc tgatgcaggc cctcaacttt aacagcgaga ccgtgcccca gaaaagcagc      480

ctcgaagagc ctgacttcta caaaaccaag attaagctgt gtatcctgct gcacgccttc      540

aggatcaggg ccgtgaccat cgacagggtg atgagctacc tgaacgccag c               591


<210>  1215
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Signal sequence

<400>  1215
atgtgccacc aacagctggt catctcttgg ttcagcctgg tgtttctggc atccccactg       60

gtggca                                                                  66


<210>  1216
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Granzyme B sequence


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Any amino acid

<400>  1216

Ile Glu Pro Asp Xaa 
1               5   


<210>  1217
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Enterokinase sequence

<400>  1217

Asp Asp Asp Asp Lys 
1               5   


<210>  1218
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Genenase sequence

<400>  1218

Pro Gly Ala Ala His Tyr 
1               5       


<210>  1219
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: PreScission protease sequence

<400>  1219

Leu Glu Val Phe Gln Gly Pro 
1               5           


<210>  1220
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: Thrombin sequence

<400>  1220

Leu Val Pro Arg Gly Ser 
1               5       


<210>  1221
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Description of Unknown: TEV protease sequence

<400>  1221

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  1222
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1222

Arg Thr Lys Arg 
1               


<210>  1223
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1223

Gly Thr Gly Ala Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu 
1               5                   10                  15      


Gly Asp Val Gly 
            20  


<210>  1224
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1224

Gly Thr Gly Ala Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg 
1               5                   10                  


<210>  1225
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1225

Leu Gln Trp Leu Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg 
1               5                   10                  15  


<210>  1226
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1226

Gly Thr Gly Ala Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu 
1               5                   10                  15      


Gly Gly 
        


<210>  1227
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1227

Gly Thr Gly Ala Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu 
1               5                   10                  15      


Gly 
    


<210>  1228
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1228

Ser Leu Asn Leu Thr Glu Ser His Asn Ser Arg Lys Lys Arg 
1               5                   10                  


<210>  1229
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1229

Cys Lys Ile Asn Gly Tyr Pro Lys Arg Gly Arg Lys Arg Arg 
1               5                   10                  


<210>  1230
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1230

Arg Gly Asp Ser 
1               


<210>  1231
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1231

Ser Ala Arg Asn Arg Arg Lys Arg 
1               5               


<210>  1232
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1232

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  1233
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1233

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  1234
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1234

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  1235
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  1235

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  1236
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Destabilizing 
       domain

<400>  1236
ggcgtgcagg tggagacaat cagccccggc gatggccgga cctttcctaa gcgcggccag       60

acatgcgtgg tgcactacac cggcatgctg ggcgacggca agaaggtgga cagctccagg      120

gatagaaaca agccattcaa gtttatgctg ggcaagcagg aagtgatcag aggatgggag      180

gagggagtgg cacagatgtc cgtgggacag ggcgccaagc tgacaatctc tccagattac      240

gcatatggag caaccggaca cccaggaatc atcccacccc acgccaccct ggtgttcgac      300

gtggagctgc tggagctgga g                                                321


