                         SEQUENCE LISTING

<110>  NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
 
<120>  A SINGLE-DOMAIN ANTIBODY FOR TARGETING PROSTATE SPECIFIC MEMBRANE
        ANTIGEN (PSMA)

<130>  NIBN-P-023-PCT

<150>  62/893,264
<151>  2019-08-29

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gly Tyr Thr Asp Ser Asn Tyr Tyr Met Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Gly Val Asn Thr Gly Arg Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Ala Cys His Phe Cys Asp Ser Leu Pro Lys Thr Gln Asp Glu Tyr 
1               5                   10                  15      


Ile Leu 
        


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Trp Pro Tyr Ser Thr Tyr Ser Met Asn 
1               5                   10  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gly Ile Ser Ser Thr Met Ser Gly Ile Ile Phe Ala Glu Ser 
1               5                   10                  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Arg Arg Asp Tyr Ser Leu Ser Ser Ser Ser Asp Asp Phe Asp Tyr 
1               5                   10                  15  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Tyr Thr Ala Ser Phe Ser 
1               5           


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gly Val Ala Val Ile Asn Val Gly Val Gly Ser Thr Tyr Tyr Ala Asp 
1               5                   10                  15      


Ser Val 
        


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Ser Leu Arg Trp Ser Arg Pro Pro Asn Pro Ile Ser Glu Asp Ala Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Ile Ser Ser Thr Met Ser Gly Ile Ile Phe Ala Glu Ser Lys Ala 
1               5                   10                  15      


Gly Gln Phe Thr Ile Ser Gln Asp Asn Ala 
            20                  25      


<210>  11
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Pro Gly Tyr Thr Asp Ser Asn Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Val Asn Thr Gly Arg Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ala Ala Cys His Phe Cys Asp Ser Leu Pro Lys Thr Gln Asp 
            100                 105                 110         


Glu Tyr Ile Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140 


<210>  12
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Arg Ser Gly Trp Pro Tyr Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Thr Met Ser Gly Ile Ile Phe Ala Glu Ser Lys 
    50                  55                  60                  


Ala Gly Gln Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Asp Tyr Ser Leu Ser Ser Ser Ser Asp Asp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135         


<210>  13
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ala Ser Phe Ser 
            20                  25                  30          


Trp Ile Gly Tyr Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Asn Val Gly Val Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Glu Asn Thr Ile Ser 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Leu Arg Trp Ser Arg Pro Pro Asn Pro Ile Ser Glu Asp 
            100                 105                 110         


Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140 


<210>  14
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Arg Ser Gly Trp Pro Tyr Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Thr Met Ser Gly Ile Ile Phe Ala Glu Ser Lys 
    50                  55                  60                  


Ala Gly Gln Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Asp Tyr Ser Leu Ser Ser Ser Ser Asp Asp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135         


<210>  15
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is Ala or a non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is Ala or a non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is Gly or a non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is Lys or a non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is Ala or a non-naturally occurring amino acid

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Pro Gly Tyr Thr Asp Ser Asn Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Xaa Pro Xaa Xaa Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Val Asn Thr Gly Arg Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Xaa Lys Asn Thr Met Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Val Ala Ala Cys His Phe Cys Asp Ser Leu Pro Lys Thr Gln Asp 
            100                 105                 110         


Glu Tyr Ile Leu Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140 


<210>  16
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is Ala or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is Ala or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is Gly or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is Lys or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is Ala or non-naturally occurring amino acid

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Arg Ser Gly Trp Pro Tyr Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Phe Arg Gln Xaa Pro Xaa Xaa Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Thr Met Ser Gly Ile Ile Phe Ala Glu Ser Lys 
    50                  55                  60                  


Ala Gly Gln Phe Thr Ile Ser Gln Asp Asn Xaa Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Asp Tyr Ser Leu Ser Ser Ser Ser Asp Asp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135         


<210>  17
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is Ala or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is Gly or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is Lys or non-naturally occurring amino acid

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ala Ser Phe Ser 
            20                  25                  30          


Trp Ile Gly Tyr Phe Arg Gln Xaa Pro Xaa Xaa Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Val Ile Asn Val Gly Val Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Glu Asn Thr Ile Ser 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Leu Arg Trp Ser Arg Pro Pro Asn Pro Ile Ser Glu Asp 
            100                 105                 110         


Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ala Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135                 140 


<210>  18
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is Ala or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  X is Ala or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  X is Gly or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  X is Lys or non-naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is Ala or non-naturally occurring amino acid

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Glu Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Arg Ser Gly Trp Pro Tyr Ser Thr Tyr 
            20                  25                  30          


Ser Met Asn Trp Phe Arg Gln Xaa Pro Xaa Xaa Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Gly Ile Ser Ser Thr Met Ser Gly Ile Ile Phe Ala Glu Ser Lys 
    50                  55                  60                  


Ala Gly Gln Phe Thr Ile Ser Gln Asp Asn Xaa Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Asp Tyr Ser Leu Ser Ser Ser Ser Asp Asp Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Tyr 
        115                 120                 125             


Pro Tyr Asp Val Pro Asp Tyr Gly Ser 
    130                 135         


