                         SEQUENCE LISTING

<110>  Erber Aktiengesellschaft
 
<120>  IMPROVED POLYPEPTIDES CAPABLE OF CONVERTING SUBSTRATE 3-KETO- 
       DEOXYNIVALENOL INTO 3-EPI- DEOXYNIVALENOL

<130>  ERB16790PCT

<150>  EP 19194632
<151>  2019-08-30

<160>  101   

<170>  PatentIn version 3.5

<210>  1
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  1

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  2
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  2

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ser Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Glu Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Arg Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Val Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Asn His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Gly Lys Leu Tyr Asp Ile Val Glu Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Ala Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Lys Asp Asn Leu Ala Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Thr Pro Glu Glu Arg Gln Lys Leu Asp Ala Val Ser Gln Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Arg Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  3
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  3

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Glu Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Asp Ile Val Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Lys Asp Asn Leu Ala Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Gln Lys Leu Asp Ala Val Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Ala Asn Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Leu Ser Thr Tyr Val Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  4
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  4

Met Glu Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly Ala Thr 
            20                  25                  30          


Ala Gln Asp Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Ile Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Ile Lys Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Gln Ala Ala Asp Lys Asn His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Ile Pro Ile Thr Gly Asp Gln Gly Leu Gly Val Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asn Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Glu Lys Leu Tyr Asp Ile Val Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Asp Asp Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ser Leu Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly Arg 
        275                 280                 285             


Asn Asp Ala Gln Phe Lys Asp Asn Leu Ala Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Ala Glu Glu Arg Ala Arg Leu Asp Ala Val Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Ala Gln Asp Arg Leu Gly 
                325                 330                 335     


Pro Val Asp Arg Asn Leu Ile Glu Pro Tyr Ala Glu Glu Leu Asn Arg 
            340                 345                 350         


Gly 
    


<210>  5
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  5

Met Gln Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Gly Glu Lys Ile Gly Gly Thr 
            20                  25                  30          


Gly Gln Asp Glu Ala Asn Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Lys Met Gly Glu Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Ser Arg His Gln Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Thr Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asn Arg Leu Tyr Asp Ile Val Asp Ala Leu Val 
                245                 250                 255     


Ala Ile Ala Glu Ala Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Asp Leu Gln Leu 
    290                 295                 300                 


Thr Ala Asp Glu Arg Gln Arg Leu Asp Ala Val Ser Gln Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Ala Asn Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Arg Asp Leu Leu Thr Pro Tyr Val Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  6
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  6

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Ser Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Gln Val Leu Ala Glu Asn Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Thr Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Ala Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Trp Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Asn Glu Ala Gln Phe Ala Asp Asn Ile Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Ser Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Arg Ile Asp Leu Asp Leu Ile Glu Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  7
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  7

Met Glu Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Ile Gly Asn Thr 
            20                  25                  30          


Ser Pro Ala Asp Ala Ala Arg Gln Val Asp Met Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Ile Leu Gly Ala Ile Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Lys Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Glu Gln Cys Lys Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Arg Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg His Gly His Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ser Ala Asp Gln Arg His Asn Ala 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Ser Gly Gly Pro Glu Thr Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Gln Glu Lys Leu Tyr Asp Val Ile Glu Glu Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Asp Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Gly Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Asn Glu Lys Gln Phe Ala Asp Asn Ile Ala Ala Ala Asp Phe Lys Leu 
    290                 295                 300                 


Ser Ala Glu Glu Arg Ala Arg Leu Asp Lys Val Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Ser Ser Gln Asp Arg Leu Ser 
                325                 330                 335     


Pro Val Asp Met Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  8
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  8

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ser Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Ile Gly Asn Thr 
            20                  25                  30          


Ser Arg Gln Asp Ala Ala Arg Gln Val Asp Met Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Ser Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Ile Leu Gly Asp Ile Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Lys Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Glu Gln Cys Lys Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Gln Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Ile Leu 
    130                 135                 140                 


Val Arg His Gly His Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Ser Lys Ala Leu Ala Ala Ala Asp Gln Arg His Asn Ala 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Ser Ala Pro Asp Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Ser Val Ile Asp Val Leu Val 
                245                 250                 255     


Ala Val Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Trp Leu Met Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly Arg 
        275                 280                 285             


Asn Glu Lys Gln Phe Ala Asp Asn Ile Ala Ala Ala Gln Leu Val Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Gly 
                325                 330                 335     


Lys Ile Asp Met Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  9
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  9

Met Glu Tyr Arg Leu Leu Gly Arg Ser Gly Leu Lys Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Asn Pro Lys Val Gly Asn Thr 
            20                  25                  30          


Ser Leu Lys Asp Ala Gln Arg Gln Ile Asp Met Cys Leu Glu Ala Gly 
        35                  40                  45              


Ile Asn Met Leu Asp Thr Ala Asn Val Tyr Thr Arg Gly Val Ser Glu 
    50                  55                  60                  


Ser Ile Ile Gly Glu Ala Leu Thr Asp Gly Arg Arg Gln Arg Thr Leu 
65                  70                  75                  80  


Leu Ala Thr Lys Val Arg Phe Pro Met Asp Asp Thr Asp Pro Asn Glu 
                85                  90                  95      


Arg Gly Leu Ser Arg Tyr His Ile Val Asn Gln Cys Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Gln Thr Pro Leu Glu Glu Thr Met Glu Ala Leu Asp Met Leu 
    130                 135                 140                 


Val Arg His Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Gly Val Ser Glu Lys Asp Ala Arg Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Thr Leu Phe Ser Arg Glu Ala 
            180                 185                 190         


Glu Asn Glu Leu Val Pro Ile Ser Leu Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Gly Gln Thr Ala Pro Glu Gly Ala Arg His Ala Gly Gly Phe Lys Glu 
225                 230                 235                 240 


Pro Pro Val His Asp Trp Glu Arg Leu Tyr Asp Ile Val Glu Val Leu 
                245                 250                 255     


Val Ser Ile Ala Glu Val Arg Gly Val Ser Gly Ala Gln Ile Ala Leu 
            260                 265                 270         


Ala Trp Leu Leu Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly 
        275                 280                 285             


Arg Thr Glu Asp Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Lys 
    290                 295                 300                 


Leu Thr Glu His Glu Arg Lys Arg Leu Asp Asp Val Ser Leu Leu Pro 
305                 310                 315                 320 


Leu Gln Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Ser Asp Arg Leu 
                325                 330                 335     


Gly Pro Ala Asp Leu Ala Leu His Ala Pro His Leu Glu Lys 
            340                 345                 350 


<210>  10
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  10

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Val Leu 
1               5                   10                  15      


Ser Val Gly Thr Val Thr Phe Gly Gly Asp Gly Leu Trp Gly Asp Thr 
            20                  25                  30          


Asp Val Thr Gly Ala Ala Arg Gln Ile Asp Met Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Ile Asp Thr Ala Asn Val Tyr Asn Lys Gly Val Ser Glu 
    50                  55                  60                  


Glu Ile Thr Gly Glu Val Leu Arg Asp Gly Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Pro Phe Gly Asp Gly Pro Asn Asp 
                85                  90                  95      


Arg Gly Leu Ser Arg His His Ile Ile Ala Gln Cys Glu Gly Ser Leu 
            100                 105                 110         


Lys Arg Leu Gln Thr Asp Val Ile Asp Leu Tyr Gln Val His Gln Trp 
        115                 120                 125             


Asp Gly Gln Thr Pro Leu Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Leu Met Lys Ala Leu Ala Val Ala Asp Ser Arg Gly Tyr Gln 
                165                 170                 175     


Arg Phe Val Ala Gln Gln Ile His Tyr Thr Leu Tyr Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Gln Pro Ile Thr Val Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Trp Leu Ser Gly Lys Tyr Thr Arg 
    210                 215                 220                 


Ala Ser Gln Pro Glu Asp Gly Arg His Val Arg Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Pro Glu Arg Leu Tyr Asp Ile Val Asp Val Ile Asn 
                245                 250                 255     


Ala Val Ala Ala Glu Arg Gly Val Ser Gly Ala Val Val Ser Leu Ala 
            260                 265                 270         


Trp Ala Leu Gln Arg Lys Gly Val Ser Ser Val Ile Val Gly Ala Arg 
        275                 280                 285             


Thr Asp Ala Gln Phe Ala Asp Asn Leu Lys Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Asp Glu Val Ala Arg Leu Asp Ala Val Ser Gln Arg Pro Leu 
305                 310                 315                 320 


Pro Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Glu Ala Asp Leu Val Leu Leu Ala Pro Tyr Leu Glu Glu Tyr Lys Arg 
            340                 345                 350         


Gly 
    


<210>  11
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  11

Met Asp Tyr Arg Leu Leu Gly Arg Ser Gly Leu Lys Val Ser Ser Leu 
1               5                   10                  15      


Ser Ile Gly Thr Ala Thr Phe Gly Gly Asp Gly Leu Trp Gly Asp Thr 
            20                  25                  30          


Asn Val Lys Glu Ala Gln Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Val Asn Leu Ile Asp Thr Ala Asn Val Tyr Ser Gly Ser Val Ser Glu 
    50                  55                  60                  


Thr Ile Ile Gly Glu Ala Leu Thr Asp Gly Arg Arg Asp Arg Leu Leu 
65                  70                  75                  80  


Ile Ala Thr Lys Val Arg Phe Pro Arg Gly Lys Gly Pro Asn Asp Arg 
                85                  90                  95      


Gly Leu Ser Arg Trp His Ile Ile Arg Glu Ala Glu Ala Ser Leu Lys 
            100                 105                 110         


Arg Met Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp Asp 
        115                 120                 125             


Gly Gln Thr Pro Leu Glu Glu Thr Leu Glu Ala Leu Asp Thr Leu Val 
    130                 135                 140                 


Arg Ser Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Ala Trp 
145                 150                 155                 160 


His Leu Met Lys Ala Leu Ala Val Ser Asn Glu Arg Asn Tyr Gln Arg 
                165                 170                 175     


Phe Val Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala Glu 
            180                 185                 190         


Phe Glu Leu Ile Pro Ala Gly Leu Asp Gln Gly Val Ser Val Leu Val 
        195                 200                 205             


Trp Ser Pro Leu Ala Gly Gly Trp Leu Ser Gly Lys Tyr Thr Arg Asp 
    210                 215                 220                 


Ser Lys Pro Ser Asp Gly Arg Gln Val Arg Gly Phe Lys Glu Pro Pro 
225                 230                 235                 240 


Ile Tyr Asp Pro Glu His Leu Trp Lys Ile Val Asp Val Val Asn Asp 
                245                 250                 255     


Val Ala Gly Ala Arg Gly Val Ser Gly Ala Gln Val Ser Leu Ala Trp 
            260                 265                 270         


Leu Leu Ser Lys Pro Ile Val Ala Ser Val Ile Val Gly Gly Arg Asn 
        275                 280                 285             


Ile Gly Gln Phe Glu Asp Asn Leu Lys Ala Ala Glu Leu Thr Leu Thr 
    290                 295                 300                 


Thr Glu Glu Leu Gln Lys Leu Asp Ala Val Ser Gln Pro Asn Leu Pro 
305                 310                 315                 320 


Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Gly Glu 
                325                 330                 335     


Pro Asp Leu Ala Leu His Arg Pro Tyr Leu Asp Lys 
            340                 345             


<210>  12
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  12

Met Asp Tyr Arg Leu Leu Gly Arg Ser Gly Leu Lys Val Ser Ser Leu 
1               5                   10                  15      


Ser Ile Gly Thr Ala Thr Phe Gly Gly Asp Gly Leu Trp Gly Asp Thr 
            20                  25                  30          


Asn Val Lys Glu Ala Gln Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Val Asn Leu Ile Asp Thr Ala Asn Val Tyr Ser Gly Ser Val Ser Glu 
    50                  55                  60                  


Thr Ile Ile Gly Glu Ala Leu Thr Asp Gly Arg Arg Asp Arg Leu Leu 
65                  70                  75                  80  


Ile Ala Thr Lys Val Arg Phe Pro Arg Gly Lys Gly Pro Asn Asp Arg 
                85                  90                  95      


Gly Leu Ser Arg Trp His Ile Ile Arg Glu Ala Glu Ala Ser Leu Lys 
            100                 105                 110         


Arg Met Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp Asp 
        115                 120                 125             


Gly Gln Thr Pro Leu Glu Glu Thr Leu Glu Ala Leu Asp Thr Leu Val 
    130                 135                 140                 


Arg Ser Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Ala Trp 
145                 150                 155                 160 


His Leu Met Lys Ala Leu Ala Thr Ser Asn Glu Arg Asn Tyr Gln Arg 
                165                 170                 175     


Phe Val Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala Glu 
            180                 185                 190         


Phe Glu Leu Ile Pro Ala Gly Leu Asp Gln Gly Val Ser Val Leu Val 
        195                 200                 205             


Trp Ser Pro Leu Ala Gly Gly Trp Leu Ser Gly Lys Tyr Thr Arg Asn 
    210                 215                 220                 


Ser Lys Pro Ser Asp Gly Arg Gln Val Arg Gly Phe Lys Glu Pro Pro 
225                 230                 235                 240 


Ile Tyr Asp Pro Glu His Leu Trp Lys Ile Val Asp Val Val Asn Glu 
                245                 250                 255     


Val Ala Ser Ala His Gly Val Ser Gly Ala Gln Val Ser Leu Ala Trp 
            260                 265                 270         


Leu Leu Ser Lys Pro Ile Val Ala Ser Val Ile Val Gly Gly Arg Asn 
        275                 280                 285             


Ile Glu Gln Phe Glu Asp Asn Leu Lys Ala Ala Glu Leu Gln Leu Thr 
    290                 295                 300                 


Ala Glu Glu Leu Gly Arg Leu Asp Ala Val Ser Gln Pro Asn Leu Pro 
305                 310                 315                 320 


Tyr Pro Tyr Trp His Gln Asn Phe Thr Ala Gln Asp Arg Leu Ser Glu 
                325                 330                 335     


Pro Asp Leu Ala Leu His Arg Pro Tyr Leu Asp Lys 
            340                 345             


<210>  13
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  13

Met Glu Tyr Arg Leu Leu Gly Arg Ser Gly Leu Lys Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Gln Gly Lys Phe Ala Ser Val 
            20                  25                  30          


Gly Asn Ser Gly Val Asp Glu Ala Arg Arg Leu Ile Asp Met Cys Ile 
        35                  40                  45              


Asp Ala Gly Val Asn Leu Ile Asp Thr Ala Asn Val Tyr Ser Asp Gly 
    50                  55                  60                  


Arg Ser Glu Glu Ile Ile Gly Glu Val Leu Gly Gly Lys Arg Pro Lys 
65                  70                  75                  80  


Asp Val Leu Ile Ala Thr Lys Ala Arg Phe Pro Met Gly Asp Gly Pro 
                85                  90                  95      


Asn Asn Gly Gly Leu Ser Arg Tyr His Leu Ile Arg Glu Cys Glu Ala 
            100                 105                 110         


Ser Leu Lys Arg Leu Arg Thr Asp Val Ile Asp Leu Tyr Gln Val His 
        115                 120                 125             


Gln Trp Asp Gly Leu Thr Pro Leu Glu Glu Thr Leu Glu Ala Leu Asp 
    130                 135                 140                 


Thr Leu Val Arg Asp Gly Lys Val Arg Tyr Leu Gly Cys Ser Asn Tyr 
145                 150                 155                 160 


Ser Ala Trp His Leu Met Lys Ala Leu Gly Ile Ser Glu Arg Glu His 
                165                 170                 175     


Arg Gln Arg Phe Val Ser Gln Gln Ile His Tyr Thr Leu Glu Ala Arg 
            180                 185                 190         


Glu Ala Glu Tyr Glu Leu Leu Pro Ile Ser Ile Asp Gln Gly Leu Gly 
        195                 200                 205             


Val Leu Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys His 
    210                 215                 220                 


Arg Arg Asp Gly Lys Ala Pro Glu Gly Ser Arg Gln Leu Glu Gly Trp 
225                 230                 235                 240 


Thr Glu Pro Pro Ile Arg Asp Glu Glu Arg Leu Trp Arg Ile Val Asp 
                245                 250                 255     


Val Leu Val Ala Ile Ala Glu Ala Arg Gly Val Ser Gly Ala Gln Val 
            260                 265                 270         


Ala Leu Ala Trp Leu Leu Glu Arg Pro Ala Val Thr Ser Leu Val Ile 
        275                 280                 285             


Gly Gly Arg Thr Glu Ala Gln Phe Lys Asp Asn Leu Ala Ala Ala Glu 
    290                 295                 300                 


Leu Lys Leu Thr Ala Glu Glu Arg Gln Arg Leu Asp Glu Val Ser Ala 
305                 310                 315                 320 


Pro Pro Val Leu Tyr Pro Tyr Trp His Gln Leu Met Thr Ala Ser Asp 
                325                 330                 335     


Arg Leu Gly Pro Ala Asp Met Pro Leu Leu Ala Pro His Leu Lys 
            340                 345                 350     


<210>  14
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  14

Met Glu Tyr Arg Leu Leu Gly Arg Ser Gly Leu Lys Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Gln Gly Lys Phe Ala Ser Val 
            20                  25                  30          


Gly Ser Ser Gly Val Asp Glu Ala Arg Arg Leu Ile Asp Met Cys Ile 
        35                  40                  45              


Asp Ala Gly Val Asn Leu Ile Asp Thr Ala Asn Val Tyr Ser Asp Gly 
    50                  55                  60                  


Arg Ser Glu Glu Ile Ile Gly Glu Val Leu Gly Gly Lys Arg Pro Lys 
65                  70                  75                  80  


Asp Val Leu Ile Ala Thr Lys Ala Arg Phe Pro Met Gly Asp Gly Pro 
                85                  90                  95      


Asn His Gly Gly Leu Ser Arg Tyr His Leu Ile Arg Glu Cys Glu Ala 
            100                 105                 110         


Ser Leu Lys Arg Leu Arg Thr Asp Val Ile Asp Leu Tyr Gln Val His 
        115                 120                 125             


Gln Trp Asp Gly Leu Thr Pro Leu Glu Glu Thr Leu Glu Ala Leu Asp 
    130                 135                 140                 


Thr Leu Val Arg Asp Gly Lys Val Arg Tyr Leu Gly Cys Ser Asn Tyr 
145                 150                 155                 160 


Ser Ala Trp His Leu Met Lys Ala Leu Gly Val Ser Glu Arg Glu His 
                165                 170                 175     


Arg Gln Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu Glu Ala Arg 
            180                 185                 190         


Glu Ala Glu Tyr Glu Leu Leu Pro Ile Ser Ile Asp Gln Gly Leu Gly 
        195                 200                 205             


Val Leu Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys His 
    210                 215                 220                 


Arg Arg Asp Thr Lys Ala Pro Glu Gly Ser Arg Gln Leu Ala Gly Trp 
225                 230                 235                 240 


Thr Glu Pro Pro Ile Arg Asp Glu Glu Arg Leu Trp Arg Val Val Asp 
                245                 250                 255     


Val Leu Val Ser Ile Ala Gln Ser Arg Gly Val Ser Gly Ala Gln Val 
            260                 265                 270         


Ala Leu Ala Trp Leu Leu Glu Arg Pro Ala Val Thr Ser Leu Val Ile 
        275                 280                 285             


Gly Gly Arg Thr Glu Ala Gln Phe Lys Asp Asn Leu Ala Ala Ala Glu 
    290                 295                 300                 


Leu Lys Leu Thr Ala Glu Glu Arg Gln Arg Leu Asp Glu Val Ser Ala 
305                 310                 315                 320 


Pro Pro Val Leu Tyr Pro Tyr Trp His Gln Leu Met Thr Ala Ser Asp 
                325                 330                 335     


Arg Leu Gly Pro Ala Asp Met Pro Leu Leu Ala Pro His Leu Lys 
            340                 345                 350     


<210>  15
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  15

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Val Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Gln Glu Thr Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Ile Met Asp Asp Tyr Ile Lys Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Ala Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Ser Glu Ala Arg Gln Val Val Val Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Thr Asn Leu Asn Arg Ala Leu Asn Asp Ser Leu Arg Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Val Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Ser Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Arg Ala Asn His Trp Thr Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Gln Asp Ala Ala Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Tyr Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Met 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Glu Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Val Ala Arg Pro Ala Val Thr Ala Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ala Val Ala Val 
    290                 295                 300                 


Thr Leu Ser Thr Glu Glu Met Glu Arg Leu Asn Arg Val Ser Ala Pro 
305                 310                 315                 320 


Ala Met Ala Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg His 
                325                 330                 335     


Arg Lys Met Asp Gly Gly Arg 
            340             


<210>  16
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Enzyme

<400>  16

Met Asp Tyr Arg Lys Leu Gly Pro Ser Gly Thr Val Val Thr Ala Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Gly Ala Glu Ala Asp Glu Ala Ala Ser His 
            20                  25                  30          


Lys Leu Leu Asp Asp Tyr Phe Ala Trp Gly Gly Asn Phe Ile Asp Thr 
        35                  40                  45              


Ala Asp Val Tyr Ser Ala Gly Lys Ser Glu Glu Ile Ile Gly Arg Trp 
    50                  55                  60                  


Leu Lys Ala Arg Pro Thr Glu Ala Arg Gln Ala Ile Val Ala Thr Lys 
65                  70                  75                  80  


Gly Arg Phe Pro Met Gly Asn Gly Pro Asn Asp Ile Gly Leu Ser Arg 
                85                  90                  95      


Arg His Leu Ser Gln Ala Leu Asp Asp Ser Leu Arg Arg Leu Gly Leu 
            100                 105                 110         


Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro 
        115                 120                 125             


Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Ser Ser Gly Lys 
    130                 135                 140                 


Ile Gly Tyr Tyr Gly Phe Ser Asn Tyr Val Gly Trp His Ile Ala Lys 
145                 150                 155                 160 


Ala Ser Glu Ile Ala Lys Ala Arg Gly Tyr Thr Arg Pro Val Thr Leu 
                165                 170                 175     


Gln Pro Gln Tyr Asn Leu Leu Met Arg Asp Ile Glu Leu Glu Ile Val 
            180                 185                 190         


Ala Ala Cys Gln Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu 
        195                 200                 205             


Gly Gly Gly Trp Leu Thr Gly Lys Tyr Lys Arg Asp Glu Met Pro Thr 
    210                 215                 220                 


Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Gly Glu Ser Tyr 
225                 230                 235                 240 


Ala Pro Arg Asn Ala Gln Glu Arg Thr Trp Ala Ile Ile Gly Thr Val 
                245                 250                 255     


Glu Glu Ile Ala Lys Ala Arg Gly Val Ser Met Ala Gln Val Ala Leu 
            260                 265                 270         


Ala Trp Thr Ala Ala Arg Pro Ala Ile Thr Ser Val Ile Leu Gly Ala 
        275                 280                 285             


Arg Thr Pro Glu Gln Leu Ala Asp Asn Leu Gly Ala Met Lys Val Glu 
    290                 295                 300                 


Leu Ser Gly Glu Glu Met Ala Arg Leu Asn Glu Val Ser Ala Pro Gln 
305                 310                 315                 320 


Pro Leu Asp Tyr Pro Tyr Gly Lys Gly Gly Ile Asn Gln Arg His Arg 
                325                 330                 335     


Lys Ile Glu Gly Gly Arg 
            340         


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is not M or X is V, I, L, M, F or A.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is not A or X is E, D, Q or N.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is not A or X is G or A.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is not V or X is M, L, F, I, R, K, Q, N, E, V, A, or Norleucin.

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is not V and/or X is M, L, F, I, R, K, Q, N, E, V, A, or 
       Norleucin.

<400>  17

Xaa His Xaa Trp Asp Xaa Xaa Thr Pro 
1               5                   


<210>  18

<400>  18
000

<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is G, R, K, Q, N, A, V, L, I, S, T, E, D

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is not M or G or X is W, S, T, F, L, V, I, A or Y

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is not E or X is T, S, R, Q, N or K.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is not E and/or X is T, S, R, Q, N or K.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is not S and/or X is E, D or Q.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is not S and/or X is E, D or Q.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is not S and/or X is P or A.

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is not P and/or X is I, L, M, A, F or V.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is R, K, Q, N, P, A, Y, W, F, T, S, H.

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is not N and/or X is D, E or N.

<400>  19

Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  20

Val His Glu Trp Asp Gly Met Thr Pro 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  21

Val His Glu Trp Asp Gly Arg Thr Pro 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  22

Val His Glu Trp Asp Gly Gln Thr Pro 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  23

Val His Gln Trp Asp Gly Leu Thr Pro 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  24

Val His Gln Trp Asp Gly Gln Thr Pro 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  25

Gly Gly Phe Arg Glu Pro Pro Val Tyr Asp 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  26

Gly Gly Ser Arg Glu Pro Pro Val Pro Asp 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  27

Gly Gly Phe Arg Glu Pro Pro Val Pro Asp 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  28

Gly Gly Phe Lys Glu Pro Pro Val His Asp 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  29

Arg Gly Phe Arg Glu Pro Pro Val Pro Asp 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  30

Glu Gly Trp Thr Glu Pro Pro Ile Arg Asp 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  31

Ala Gly Trp Thr Glu Pro Pro Ile Arg Asp 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  32

Arg Gly Phe Lys Glu Pro Pro Ile Tyr Asp 
1               5                   10  


<210>  33
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  33

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Asp Gly 
1               5                   10                  15      


Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Tyr Asp 
        


<210>  34
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  34

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Asp Gly 
1               5                   10                  15      


Gly Pro Glu Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro Pro Val 
            20                  25                  30          


Pro Asp 
        


<210>  35
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  35

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Asp Gly 
1               5                   10                  15      


Gly Pro Glu Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro Pro Val 
            20                  25                  30          


Pro Asp 
        


<210>  36
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  36

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Asn Gly 
1               5                   10                  15      


Gly Pro Asp Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Tyr Asp 
        


<210>  37
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  37

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Asp Gly 
1               5                   10                  15      


Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Pro Asp 
        


<210>  38
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  38

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Thr Gly 
1               5                   10                  15      


Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Tyr Asp 
        


<210>  39
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  39

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Ser Gly 
1               5                   10                  15      


Gly Pro Glu Thr Gly Arg His Val Gly Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Tyr Asp 
        


<210>  40
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  40

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Asp Ser 
1               5                   10                  15      


Ala Pro Asp Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Tyr Asp 
        


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  41

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg Gly Gln 
1               5                   10                  15      


Thr Ala Pro Glu Gly Ala Arg His Ala Gly Gly Phe Lys Glu Pro Pro 
            20                  25                  30          


Val His Asp 
        35  


<210>  42
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  42

Ser Pro Leu Ala Gly Gly Trp Leu Ser Gly Lys Tyr Thr Arg Ala Ser 
1               5                   10                  15      


Gln Pro Glu Asp Gly Arg His Val Arg Gly Phe Arg Glu Pro Pro Val 
            20                  25                  30          


Pro Asp 
        


<210>  43
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  43

Ser Pro Leu Ala Gly Gly Trp Leu Ser Gly Lys Tyr Thr Arg Asp Ser 
1               5                   10                  15      


Lys Pro Ser Asp Gly Arg Gln Val Arg Gly Phe Lys Glu Pro Pro Ile 
            20                  25                  30          


Tyr Asp 
        


<210>  44
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  44

Ser Pro Leu Ala Gly Gly Trp Leu Ser Gly Lys Tyr Thr Arg Asn Ser 
1               5                   10                  15      


Lys Pro Ser Asp Gly Arg Gln Val Arg Gly Phe Lys Glu Pro Pro Ile 
            20                  25                  30          


Tyr Asp 
        


<210>  45
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  45

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys His Arg Arg Asp Gly 
1               5                   10                  15      


Lys Ala Pro Glu Gly Ser Arg Gln Leu Glu Gly Trp Thr Glu Pro Pro 
            20                  25                  30          


Ile Arg Asp 
        35  


<210>  46
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  46

Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys His Arg Arg Asp Thr 
1               5                   10                  15      


Lys Ala Pro Glu Gly Ser Arg Gln Leu Ala Gly Trp Thr Glu Pro Pro 
            20                  25                  30          


Ile Arg Asp 
        35  


<210>  47
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  47
atgacccgat ttgcccatta tcccagcctg accgatatgc ccgtcgtcat ctcaggcggt       60

gcctcgggca tcggcgaaag cctggtgcga aactttgccg cccagggcgc cagggtcggt      120

ttcgtcgata tcgccgtcga cgccggtgaa cgcctcgccg ccgaattgac ggggcagggg      180

caaagcgtag ccttcaccgc ctgcgacatc accgataccc aggcctatca atccgccatt      240

gccggcttcg ccgccaccca tggcgatgcc ctggccctgg tcaacaatgc cgcccatgac      300

cagcgccacg attgggctga ggtcacccct gcctattggg acgatcgcat ggcggtcaac      360

ctcaagcatg cctttttcgc catccaggcc gtggcgccgg gcatggtccg cgccgggcgc      420

ggctccatca tcaataccgg ctcgatcagc tggatgatca tgtcctcccg cattcccgtc      480

tatgaaaccg ccaaggccgc catccatggc ctcacccgcg gcatggcgcg cgaactgggg      540

cagtcgggca ttcgcgtcaa ttccctggtg cccggctggg tcatgaccga gcggcaattg      600

acccattggc tcgatgccga gggcgagcgg gccatcgcac aaaaccaggt gctggccggc      660

cgggtctatc ccgacgatgt cgcgcgcatg gccctgttcc ttgccgccga cgacagcgcc      720

atgatttcgg cccagcaatt tgtcgtcgat ggcggctggg ccaatgcctg a               771


<210>  48
<211>  1086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  48
atgagccgca ttttcaacgt cgccatcgtc ggggtcggca tcggccgcag ccacctggtc       60

gagggctatg tgcccaatgc cgacaaatac aaggtcgtcg cgctgtgcga tctcaatgtc      120

gagcgcatga cgcccattgc cgacgaattc ggcgtcgagc gccgcatcac caatttcgac      180

gatatcctcg ccatggacga tatcgacatc atcgatatct gcaccccgcc gggcctgcat      240

tatcccatgg tcatggcggc gctgaaggcc ggcaagcatg taatctgcga aaagccgctg      300

gtcggctcgc tcgcccaggt cgatgaagtc attgcccagg aaaagatctc caagggcaag      360

ctgatgccgg tgttccagta tcgctttggc gacggcatcg aacaggccaa ggccatcatc      420

gatgccggca ttgccggcaa gccattcgtc ggcacggtgg aaaccatgtg gcgccgtggc      480

cccgattatt atgccgtgcc atggcgcggc aaatgggcca ccgaactggg cggcgtgctg      540

atgacccatg ccatccacca gcacgatctc ttcacctatc tcatgggcga tgtgacgcgg      600

ctcttcggcc gggtcgccac ccgcgtcaac gccattgaag tggaagactg cgttaccgcc      660

agccttgagc tcgaaaatgg cgccctgggc agctttaccg ccacgctggg cgcagccgag      720

gaaatcacaa ggctgttcct gaccttcgag aacgtcacct tcgaaagcga ttacgaggcc      780

tataatcccg gcgccaagcc gtggcgcatc cagccgcgca atcccgagac ggcggcgaaa      840

atcgacgccc tgctcaagga ctggaagcat gtgccctcgc gtttcgaaac gcagatggcc      900

cgcttccatg cggccctctt gggtgaagcg ccgatgccgg tgacctcggc cgattcgcgc      960

cgggcgctgg aaatcgtcac cgccttctac cattcctcga ctacccacga agatgtggcc     1020

ctgcccatcg cgtccgacca tccgcgttat cagagctggg ttccgcccca gttccgcgct     1080

gcctga                                                                1086


<210>  49
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  49
atggactatc gctatctcgg ccgctcgggc cttagggttt cggtgctgac catgggcaca       60

atgacctttg gcggctcgga aaaggtgggg catacagccc aggccgatgc gacgcgccag      120

attgatctct gccttgatca cggcatcaac ctgctcgaca ccgccaatgt ctataatgcc      180

ggggtctccg aggagatgat cggggtggcg ctgagcgaac atggccggcg gcaaaaggct      240

ttgattgcca ccaaggtgcg cttcaggatg ggtaacgggc ccaatgaagt ggggctgagc      300

cggcatcata tcattgccca ggccgaggcg agcctcaagc ggctcaagac cgatgtcatc      360

gatctctacc aggtgcatga atgggatggg atgacgccca tcgaggagac gatggaagcg      420

ctcgatacgc tcgtgaaaca gggcaaggtg cgctatgtcg gctgctcgaa ttattcgggc      480

tggcacatca tgaaggcgct ggctgcggcc gacaaacatc atggccagcg cttcatctcc      540

cagcagatcc actacacgct gcattcgcgc gaagccgaat atgaactggt gccgatcagc      600

caggaccagg ggctgggtat tctgatttgg tcgccgctgg cgggcggact gctctcgggc      660

aagtatcgtc gcgatggcgg gcccgatgcc ggccgccatg ttggaggctt ccgcgagccg      720

ccggtttatg actgggacaa gctctacgac attatcgacg tcatcgtcgc cattgcccgg      780

gagcgcgatg tgtcgggcgc gcaggtggcg ttggcctggg cattggggcg gccgggcgtg      840

acctcggcca ttatcggtgg ccgtagcgag gcccagttcc gcgacaatct ggcggcggcc      900

gaactcaagc tgaccgatga cgagcgcgcc cggctcgatg cggccagccg gccgccattg      960

ctttatccct attggcacca gtcttttacc gcccaggacc ggctggacca gatcgacctg     1020

gacctgatcg ggccctatgc cgaggagttt aaacgtggct ga                        1062


<210>  50
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  50
atggacttga atttgcgcga caaggttgcc gtcattaccg ggggaacggt ggggatcggc       60

ctggccattg ccgaaggcct ggcggcggag ggcgtcaatc tggtgctggt ggggcgcgac      120

aagctgcggg ctgacgatgc ggcagcgctt gtggccgaca agttcgggat tatcgccacg      180

gcgatcagcg cggatgtcgc gactgccgaa gggtgcgatg ccgtgatcaa gggcacggcc      240

aaggcctttg gtggcgccga tatcctgatc aacaatgccg ggaccgggtc gaacgagacc      300

attgccgagg ccgatgatgc caaatggcaa tattattggg acctgcatgt gatggcggcc      360

gtgcggctgg cgcgggggct ggtgccggga atgaaaaagc ggggcggcgg cgtcgtgctg      420

cacaatgcct cgatctgcgc ggtgcagccg ctctggtatg agccgatcta caacaccacc      480

aaggccgcct tgatgatgtt ttccaagacg ctggccaatg aggtggtggg cgacaatatt      540

cgcgtcaata ccatcaatcc cgggctggtg ctgacgcccg attgggtcaa gaccgccaag      600

cagattgccg gcgaagatgg ctggcaggcg catctgcaag gggtggccga cgaggcgggc      660

ggcatgaagc gcttcgcgac gcccgaggaa ttggccaatt tcttcgtctt catgtgttcg      720

gacagagcca gctattccac cggctcgacc tattttgtcg atggcggctg gctcaagacg      780

gtttga                                                                 786


<210>  51
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  51
atggaactcg gactctattc cttcgccgaa aacacgcccg atcccctgaa cggccgccgc       60

ctgcaaagcc cggccgaacg tctcaaggac ctgctggaag aaatcgaact ggccgaccag      120

ctcggcctat ccttttacgg cctgggcgaa caccaccgcc ccgactacac cgcttccgcg      180

cccgtcacca tcctggccgc cgccgccgcg cgcaccaagt cgatccgcct ctctaccgcg      240

gtcaccgtgc tcagctcgga agaccccatc cgcgtctatc agcaattcgc cacgctcgat      300

aatctcagca atggccgcgc cgagatcatg gccggccgcg gctccttcat cgagagcttc      360

cccctcttcg ggctcgacct caacgattac gacgcgctgt tcgaggaaaa gctcgaaatg      420

ctgctcaaaa tccgcgaagg cggcaaggtc acctggcccg gcagcaccca taccaagccc      480

atccccggca ttgccatcta tcccatcccg gtccagcagc ccctgccgct ctggatcgcc      540

gtcggcggca cgccaaattc cgttgcccgc gcggcctatt acggcctgcc cctgatgatc      600

gccatcatcg gcggtcagcc gcgccagttt gcgccgctgg tcgatttcta ccgcgaaacc      660

gctgaaaagg tcggccgcga ccccaaatcg ctgcccgtcg gcatcagctc gcacggcttc      720

atcgccgccg acagccagga cgcccgcgac atcgccttcc ccgcccatag cgaggccatg      780

agccgcatcg gcaaggaacg cggttggccg cccaccaccc gcgcccaatt cgacgccggc      840

gccacgccca acggcgccta tttcatgggg tctccgcagg aagtcatcga caagattctg      900

atgcagcacg aatggttcaa acacgaccgc ttcggcctgc aattcagcgt cggcaccctg      960

ccccacgaca aggtcatgaa agccatcgag ctttacggca ccgtggtcaa gccggcggtg     1020

gacaaggcgc taggctaa                                                   1038


<210>  52
<211>  1026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  52
atgagcactg aaatcgtcac cgatgtcgtt gtgattggcg cgggcccctg cgggctgttt       60

gcggccttcg aactcgggct gctcgacctc aaatgccatt tcatcgacat tctggaccgc      120

cccggcgggc agtgcgccga gctttatccc gaaaagccga tctacgatat tcccggcttc      180

ccggtggtga ccggccagga tctgaccgac aatctgatgg cccagatcgc gcccttcgcc      240

cccgaattcc acttcaaccg catggtcaat tcgatcgaga agcaggaaga cggctcgttt      300

aagctcgaaa ccgacgccga cgagattttc cacgcgaagg tcgtggtgat cgcggccggc      360

ggcggctcgt tccagcccaa gcgcccgccg gtcgacaata tcgaagccta tgaaaacaag      420

tcggttttct attcggtccg caagatggac gatttccgtg accaggacgt ggtgatcgtc      480

ggcggcggcg attccgccct cgactggacg ctcaacctgc agcccatcgt gcgctcgctg      540

accctggtac accgccgcga tgccttcaag gccgcgcccg cttcggtcaa caagatgaag      600

gaaatggtcg ccgagggtaa gatcaatttc ctgctcggcc aggtggccaa gctcgatggc      660

gaaaacggcc agatcaacca cgtgcatctg accaccgatg ccggcgatct ctcggtgccc      720

gccacccgcc tgctgccctt cttcggcctc accatgaagc tgggtccggt ggccgattgg      780

ggccttgagc tcaatgacaa tacgatcaag gtcgataccg aaaagttcga gacctcggtg      840

cccggcattt tcgccattgg cgacatcaac tggtatccgg gcaagctcaa gctgatcctc      900

tccggcttcc acgaggctgc cctcatggcc caggccgcca agaagattgt gtcgcccgac      960

gagcgcgtgg tgttccaata caccaccagc tccaccaagc tgcagaagaa gctgggcgtc     1020

gcctag                                                                1026


<210>  53
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  53
atggactatc gctatctcgg gcgctcgggc ctgaaagtct cgagcatgac catgggcacc       60

atgacctttg gcggcagcga aaagatcggc aataccagcc gacaggacgc ggcgcggcag      120

gtggatatgt gtctcgatgc gggcatcaac ctctatgaca gcgccaatgt ctataatgcg      180

ggggtgtccg aggaaatcct gggcgacatt ctcgccgaaa acgggcggcg gcagaaagcg      240

ctgatcgcca ccaaggtacg cttcaagatg ggcgatggcc ccaacgaggc cgggctcagc      300

cgacaccata tcatcgagca gtgcaaggcg agcctcaaac gcctcaagac cgatgtgatc      360

gacctctatc aggtgcatga atgggatggg cagaccccca tcgaggaaac gatggaagcg      420

ctcgacattc tcgtgcgcca cggccatgtg cgctatatcg ggtgctccaa ttattcgggc      480

tggcatattt ccaaggccct tgccgccgcc gaccagcggc acaatgcgcg ctttgtgtcc      540

cagcagatcc attattcgct gcatagccgc gacgccgaat atgagctggt gccgatttcc      600

caggaccagg ggctgggcat tctcgtctgg tcgccgctgg cgggcgggtt gctttcgggc      660

aagtatcgcc gggacagcgc gccggacagc gggcggcatg tcggcgggtt ccgcgagccg      720

ccggtctatg actgggacaa gctctattcg gtcatcgacg tgctggtggc ggtggccgag      780

gagcgtggcg tttcgggggc gcaggtggcg ctgagctggc tgatgggacg cccgggcgtc      840

acttccgtca tcatcggcgg acgtaacgaa aagcagtttg ccgacaatat cgcagcggcc      900

cagctcgtgc tcagtgacga ggaacgcgcc cggctcgatg cggccagccg accgccgttg      960

ctctatccct actggcacca gtccttcacc gcgcaggatc ggctgggcaa gatcgacatg     1020

gatttgatcg gtccttatgc cgaggagttc aagcgtggct ga                        1062


<210>  54
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  54
atggaatacc gcttgctcgg gcgctcggga ctgaaggtct cgacccttac catgggcacg       60

atgacgttcg gggggaaccc gaaggtcggc aataccagcc tcaaggacgc gcagcgccag      120

atcgacatgt gtctggaggc gggcatcaac atgctcgaca cggccaatgt ctatacgcgg      180

ggcgtgtcgg aaagcattat cggggaggca ctgaccgatg ggcggcgcca gcggacgctg      240

ctggcgacca aggtgcgctt cccgatggac gacaccgacc ccaacgagcg gggactgtcg      300

cgctaccaca tcgtcaacca gtgcgaggca agcctcaagc ggctcaagac cgatgtgatc      360

gacctctacc aggtgcatga atgggacggg cagaccccgc tcgaggagac catggaagcg      420

ctcgacatgc tcgtgcgcca cggcaaggtc cgctatatcg gctgctcgaa ctattcgggc      480

tggcacatca tgaaggcgct cggcgtttcc gagaaggacg cccggcagcg cttcgtctcc      540

cagcagatcc actacacgct gttttcgcgc gaggcggaga acgagctggt gccgatcagc      600

ctcgaccagg ggctgggcat tctcatctgg agcccgctgg cgggcggcct gctttcgggc      660

aagtatcgcc gcggccagac ggcgccggaa ggggcgcgcc atgccggggg cttcaaggag      720

ccgccggtgc atgactggga gcggctctac gatatcgtgg aagtgctggt ttcgatcgcc      780

gaggtgcgcg gggtttcggg cgcgcagatc gcgctggcct ggctgctggg gcgcccgggg      840

gtgacctcgg tgatcatcgg cgggcgcacg gaagaccagt tcagggataa cctggcggcg      900

gccgaactca agctgaccga gcatgagcgc aagcggctag acgacgtgtc gctgctgccg      960

ctgcaatatc cctactggca ccagagcttt acggcctcgg accggctggg gccggcggac     1020

ctggcgctgc atgcacccca tctcgaaaaa tag                                  1053


<210>  55
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  55
atggactacc gctatctcgg ccggtcgggc ctcaaggttt cggtgctgag cgtcgggacg       60

gtgacgttcg gcggcgacgg gctgtggggc gatacggacg tcaccggcgc cgcccggcag      120

atcgacatgt gcctcgatgc aggcatcaac ctcatcgata ccgccaatgt ctacaacaag      180

ggcgtttcgg aagagatcac cggcgaggtg ctgcgcgacg gcggtcggcg gcagcgcgcg      240

ctgatcgcca ccaaggtgcg ctttccgttc ggcgacggtc ccaatgaccg cgggctgtcg      300

cgccaccaca tcatcgccca gtgcgagggc agcctcaaac gcctccagac cgacgtcatc      360

gatctctacc aggtccatca gtgggacggg cagacgcccc tcgaggagac gatggaagcc      420

ctcgataccc tggtgcggca ggggaaggtc cgctacatcg gctgctcgaa ctattcgggc      480

tggcacctga tgaaggcgct cgccgtcgcc gacagccgcg gctaccagcg gttcgtcgcc      540

cagcagatcc actacaccct ctattcgcgc gaggccgaat acgagctgca gccgatcacc      600

gtcgaccagg ggctcggcat actcgtctgg agcccgctcg ccggcgggtg gctctcgggc      660

aagtacacgc gcgccagcca gcccgaggac ggccgacacg tgcgcggttt ccgcgagccg      720

ccggtgcccg atcccgagcg gctctacgac atcgtcgatg tcatcaatgc ggttgccgcc      780

gagcggggcg tttcgggcgc ggtcgtttcg ctggcttggg ctttgcagcg caagggcgtc      840

tcgtcggtga tcgtgggcgc gcgcaccgac gcgcagttcg ccgataacct caaggccgcc      900

gatctaaagc tcagcgacga cgaggtcgcc cggctcgacg ccgtcagcca gcgtccgctt      960

ccctatccct attggcacca gtccttcacc gcccaggacc gcttgagcga agccgatctc     1020

gtgctgctcg ccccttatct cgaggagtac aagcgtggct ga                        1062


<210>  56
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  56
atggactatc gattgctcgg ccgttccggc ctcaaggtgt cgtcgctgtc gatcggcacg       60

gcgacgttcg gcggcgacgg gttgtggggc gacaccaacg tcaaggaggc gcagcgccag      120

atcgacctct gcctcgacca cggcgtcaac ctgatcgaca ccgccaatgt ctattcgggc      180

agcgtgtcgg agacgatcat cggcgaggcg ctgaccgatg gccggcgcga ccgcttgctg      240

atcgccacca aggtgcgctt ccccaggggc aagggaccga acgatcgcgg gctcagccga      300

tggcacatca tccgtgaggc ggaagcctcg ctgaagcgga tgaagaccga cgtcatcgac      360

ctgtaccagg tgcatgagtg ggatgggcag acgccgctcg aggagacgct ggaagcactc      420

gacaccctcg tccgctccgg caaggtccgc tatatcggct gctcgaacta ttcggcctgg      480

cacctgatga aggcgctcgc ggtttccaac gagcgcaact accagcgctt cgtttcccag      540

cagatccact acacgctgca ctcgcgcgaa gccgagttcg agctgatccc ggccggcctc      600

gaccagggtg tctcggtgct ggtgtggtcg ccgctcgccg gcgggtggct ctcgggcaag      660

tacacccgcg attccaagcc gagcgacggc cggcaggtgc gcggcttcaa ggagccgccg      720

atctacgatc ccgagcatct gtggaagatc gtcgacgtgg tcaacgacgt ggcgggcgcg      780

cgtggcgttt ccggcgcgca ggtgtcgctt gcctggttgc tgtcgaagcc gatcgtcgct      840

tcggtgatcg tcggcggccg caatatcgga cagttcgaag acaacctcaa agccgcggaa      900

ctgactctca ccaccgagga gctgcagaag ctcgacgcgg tcagccagcc gaacctgccc      960

tacccgtact ggcaccagag ctttaccgcg caggaccggc tcggtgagcc cgacctggcg     1020

ctgcaccgcc cctatctcga caagtga                                         1047


<210>  57
<211>  1047
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  57
atggactatc gattgctcgg ccgttccggc ctcaaggtct cgtcgctgtc gatcggcacg       60

gcgacgttcg gcggcgatgg gttgtggggc gataccaacg tcaaggaggc gcagcgccag      120

atcgacctct gcctcgacca tggcgtcaac ctgatcgaca ccgccaacgt ctattcgggg      180

agcgtctcgg aaacgatcat cggcgaggcg ctgaccgacg ggcggcgtga tcggctgctg      240

atcgccacca aggtgcgctt cccacgcggc aaggggccca atgatcgcgg cctcagccgc      300

tggcacatca tccgcgaggc ggaagcgtcg ctcaaacgga tgaagaccga cgtcatcgac      360

ctctaccagg tgcatgagtg ggacgggcag acgccgctcg aggaaacgct ggaggcgctc      420

gatacgctcg tccgctcggg caaggtccgc tatatcggct gctcgaacta ttcggcctgg      480

cacctgatga aggcgctcgc cacctcgaac gagcgcaact accagcgctt cgtctcccag      540

cagatccact acacgctgca ttcgcgtgag gccgagttcg agctgatccc ggccgggctc      600

gaccagggcg tttcggtgct ggtgtggtcg ccgctggccg gcgggtggct gtcgggcaag      660

tacacccgca actcgaagcc gagcgatggc cggcaggtgc gcggcttcaa ggagccgccg      720

atctatgatc cggagcacct gtggaagatc gtcgatgtgg tcaacgaagt ggccagcgcg      780

catggcgtct ccggcgcgca ggtgtcgctg gcctggctgt tgagtaagcc gatcgttgcc      840

tcggtgatcg tcggcggccg caatatcgag cagttcgagg acaacctgaa agccgccgag      900

ctgcagctca ccgccgagga actgggcaga ctcgacgcgg tcagccagcc gaacctcccc      960

tacccctact ggcaccagaa ctttaccgcg caggatcgcc tcagcgagcc tgacctggcg     1020

ctgcaccggc cctatctcga caaatga                                         1047


<210>  58
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  58
atggaatatc gactgcttgg ccgctccggc ctcaaagtct ccaccctcac gatgggcacg       60

atgaccttcg gcggccaggg caagttcgcc tcggtcggca actccggcgt cgacgaagca      120

cgccggctga tcgacatgtg catcgatgcc ggcgtcaatc tcatcgatac ggcgaacgtc      180

tactccgatg gccgttcgga agaaatcatc ggcgaagtgc tcggcggcaa gcgtccgaag      240

gacgtactga tcgcgaccaa ggcacgcttt ccgatgggcg acggccccaa caacggcggc      300

ctctctcgct atcacctgat tcgcgagtgc gaagcgagcc tgaagcgcct gcgcacggac      360

gtgatcgatc tctaccaggt tcaccagtgg gatggcctga ccccgctgga agaaaccctg      420

gaagcgctcg acaccctggt tcgcgacggc aaggtgcgtt acctgggctg ctccaactat      480

tccgcgtggc acctgatgaa ggcgctcggc atcagtgagc gcgagcatcg ccagcggttc      540

gtcagccaac agatccatta cacgctggag gcgcgcgagg ccgaatacga gctgctgccg      600

atctcgatcg accagggcct cggcgtcctc gtctggagtc cgcttgccgg tggcctgctt      660

tcgggcaagc accgtcgcga tggcaaggca ccggagggct cacgtcagct ggagggctgg      720

accgagccgc cgatccgcga cgaagagcgc ctttggcgca tcgtcgacgt gctggtggcc      780

atcgccgaag cgcgcggcgt gtcgggtgca caggtcgcgc tggcctggct gctcgagcgt      840

cccgcggtga cctccctggt catcggcggt cgtaccgagg cgcagttcaa ggacaacctc      900

gccgccgccg agctgaagct cacggccgaa gagcgtcagc ggctggacga ggtcagtgcg      960

ccgccggtgc tctacccgta ctggcaccag ctgatgacgg cgtcggaccg cctgggtccg     1020

gcggacatgc cattgctggc gccgcatctg aagtaa                               1056


<210>  59
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  59
atggaatacc gactgcttgg ccgctccggc ctcaaagtct ccaccctcac gatgggcacg       60

atgaccttcg gcggccaggg caaattcgcc tcggtcggta gctccggcgt cgacgaagcg      120

cgccggctga tcgacatgtg catcgacgcc ggcgtgaatc tcatcgacac ggcgaacgtc      180

tattccgacg gtcgttcgga agagattatc ggtgaagtgc tcggcggcaa gcgtccgaag      240

gacgtcctga tcgcgaccaa ggcgcgcttt cccatgggtg atggcccgaa ccatggtggc      300

ctgtcgcgct atcacctgat tcgcgaatgc gaagccagcc tgaagcggct gcgcacggac      360

gtgatcgatc tctaccaggt tcaccagtgg gatggcctga cgcctctgga ggaaaccctg      420

gaagcgctcg acaccctcgt tcgcgacggc aaggtgcgtt acctgggttg ctccaactat      480

tccgcctggc acctgatgaa ggcgctcggc gtgagcgagc gtgagcaccg ccagcgtttc      540

atcagccagc agatccatta cacgctggaa gcgcgcgaag ccgaatacga actgctgccg      600

atttcgatcg accagggcct cggcgtgctg gtgtggagtc cgctcgccgg cgggctgctt      660

tcgggcaagc accgtcgcga taccaaggcc ccggaaggct cgcgccagct ggccggctgg      720

accgaaccgc cgatccgcga cgaagagcgc ctgtggcgcg tcgtcgacgt actggtttca      780

atcgcccaat cgcgtggcgt gtcgggagcg caggtcgcgc tggcctggtt gctcgagcgt      840

cctgcggtca cctcgctggt gatcggtggt cgtaccgagg cacagttcaa ggacaacctg      900

gcggccgccg aactgaagct cacggccgaa gagcgtcagc gtctggatga agtcagcgcg      960

ccgccggtgc tctatccgta ctggcaccag ttgatgaccg catcggatcg cctgggtccg     1020

gccgacatgc ccctgctggc gccgcacctc aaataa                               1056


<210>  60
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  60
atggaatacc gctatctcgg ccgctcaggc ttgaaggtgt cgacattgac catgggcacc       60

atgacctttg gcggctcgga aaaggttggg gcgacggcgc aagacgatgc gacgcgccag      120

atcgacctgt gcctcgatgc agggatcaat ctgctcgaca cggccaatgt ctacaatgcc      180

ggggtctccg aggaaatgat tggcgtggcg ctggccgaga atggtcgccg ccagaaagca      240

ctcgtagcca ccaaggtccg cttcaagatg ggcgatgggc ccaacgagat cggcctcagc      300

cgtcaccata ttattgccca ggccgaagcc agccttaagc gcttgaaaac agacgttatt      360

gatctctatc aggtccacga atgggacggc atgacgccca tcgaggagac gatggaagcg      420

ctcgataccc tgatcaagca gggcaaagtc cgctatatcg gctgctcaaa ttattcgggc      480

tggcatatca tgaaggcgct gcaggccgcc gacaaaaacc acggccagcg cttcatcagc      540

cagcagatcc actacacgct gcattcgcgc gaagccgaat atgaactgat cccgatcact      600

ggggatcaag gccttggcgt cctcatctgg tcgccgctgg ccggtggttt gctctcgggc      660

aaataccgtc gcaacggtgg ccctgacagc gggcgccatg tcggcggctt ccgcgagccg      720

ccggtttatg actgggagaa gctctacgac atcgtcgatg tgatcgtgga tattgctgat      780

gaccgcggcg tgtcgggtgc acaggttgcg ctggcatggt cgctggggcg gccgggtgta      840

acctcggtga tcatcggtgg ccgcaatgat gcccagttca aagacaatct ggcggcagcc      900

gagttgaagc tgacggcgga agagcgcgcg cgacttgacg cggtcagccg tccaccgctg      960

ctctatcctt attggcatca gacgtttacg gcgcaggacc ggttaggccc tgtcgatcga     1020

aacctgatcg aaccctatgc agaggaattg aaccgtggct ga                        1062


<210>  61
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  61

Met Arg Phe Glu Tyr Leu Arg Gln Asn Val Val Gly Leu Ala Leu Ser 
1               5                   10                  15      


Thr Ala Leu Ile Ala Ser Leu Ser Gly Pro Ala Phe Ala Gln His Asp 
            20                  25                  30          


Ala Asn Ala Ala Ala Glu Pro Ser Lys Ala Gly Gln Ser Ala Ile Glu 
        35                  40                  45              


Asn Phe Gln Pro Val Thr Ala Asp Asp Leu Ala Gly Lys Asn Pro Ala 
    50                  55                  60                  


Asn Trp Pro Ile Leu Arg Gly Asn Tyr Gln Gly Trp Gly Tyr Ser Pro 
65                  70                  75                  80  


Leu Asp Gln Ile Asn Lys Asp Asn Val Gly Asp Leu Gln Leu Val Trp 
                85                  90                  95      


Ser Arg Thr Met Glu Pro Gly Ser Asn Glu Gly Ala Ala Ile Ala Tyr 
            100                 105                 110         


Asn Gly Val Ile Phe Leu Gly Asn Thr Asn Asp Val Ile Gln Ala Ile 
        115                 120                 125             


Asp Gly Lys Thr Gly Ser Leu Ile Trp Glu Tyr Arg Arg Lys Leu Pro 
    130                 135                 140                 


Ser Ala Ser Lys Phe Ile Asn Ser Leu Gly Ala Ala Lys Arg Ser Ile 
145                 150                 155                 160 


Ala Leu Phe Gly Asp Lys Val Tyr Phe Val Ser Trp Asp Asn Phe Val 
                165                 170                 175     


Val Ala Leu Asp Ala Lys Thr Gly Lys Leu Ala Trp Glu Thr Asn Arg 
            180                 185                 190         


Gly Gln Gly Val Glu Glu Gly Val Ala Asn Ser Ser Gly Pro Ile Val 
        195                 200                 205             


Val Asp Gly Val Val Ile Ala Gly Ser Thr Cys Gln Phe Ser Gly Phe 
    210                 215                 220                 


Gly Cys Tyr Val Thr Gly Thr Asp Ala Glu Ser Gly Glu Glu Leu Trp 
225                 230                 235                 240 


Arg Asn Thr Phe Ile Pro Arg Pro Gly Glu Glu Gly Asp Asp Thr Trp 
                245                 250                 255     


Gly Gly Ala Pro Tyr Glu Asn Arg Trp Met Thr Gly Ala Trp Gly Gln 
            260                 265                 270         


Ile Thr Tyr Asp Pro Glu Leu Asp Leu Val Tyr Tyr Gly Ser Thr Gly 
        275                 280                 285             


Ala Gly Pro Ala Ser Glu Val Gln Arg Gly Thr Glu Gly Gly Thr Leu 
    290                 295                 300                 


Ala Gly Thr Asn Thr Arg Phe Ala Val Lys Pro Lys Thr Gly Glu Val 
305                 310                 315                 320 


Val Trp Lys His Gln Thr Leu Pro Arg Asp Asn Trp Asp Ser Glu Cys 
                325                 330                 335     


Thr Phe Glu Met Met Val Val Ser Thr Ser Val Asn Pro Asp Ala Lys 
            340                 345                 350         


Ala Asp Gly Met Met Ser Val Gly Ala Asn Val Pro Arg Gly Glu Thr 
        355                 360                 365             


Arg Lys Val Leu Thr Gly Val Pro Cys Lys Thr Gly Val Ala Trp Gln 
    370                 375                 380                 


Phe Asp Ala Lys Thr Gly Asp Tyr Phe Trp Ser Lys Ala Thr Val Glu 
385                 390                 395                 400 


Gln Asn Ser Ile Ala Ser Ile Asp Asp Thr Gly Leu Val Thr Val Asn 
                405                 410                 415     


Glu Asp Met Ile Leu Lys Glu Pro Gly Lys Thr Tyr Asn Tyr Cys Pro 
            420                 425                 430         


Thr Phe Leu Gly Gly Arg Asp Trp Pro Ser Ala Gly Tyr Leu Pro Lys 
        435                 440                 445             


Ser Asn Leu Tyr Val Ile Pro Leu Ser Asn Ala Cys Tyr Asp Val Met 
    450                 455                 460                 


Ala Arg Thr Thr Glu Ala Thr Pro Ala Asp Val Tyr Asn Thr Asp Ala 
465                 470                 475                 480 


Thr Leu Val Leu Ala Pro Gly Lys Thr Asn Met Gly Arg Val Asp Ala 
                485                 490                 495     


Ile Asp Leu Ala Thr Gly Glu Thr Lys Trp Ser Tyr Glu Thr Arg Ala 
            500                 505                 510         


Ala Leu Tyr Asp Pro Val Leu Thr Thr Gly Gly Asp Leu Val Phe Val 
        515                 520                 525             


Gly Gly Ile Asp Arg Asp Phe Arg Ala Leu Asp Ala Glu Ser Gly Lys 
    530                 535                 540                 


Glu Val Trp Ser Thr Arg Leu Pro Gly Ala Val Ser Gly Tyr Thr Thr 
545                 550                 555                 560 


Ser Tyr Ser Ile Asp Gly Arg Gln Tyr Val Ala Val Val Ser Gly Gly 
                565                 570                 575     


Ser Leu Gly Gly Pro Thr Phe Gly Pro Thr Thr Pro Asp Val Asp Ser 
            580                 585                 590         


Ala Ser Gly Ala Asn Gly Ile Tyr Val Phe Ala Leu Pro Glu Lys Lys 
        595                 600                 605             


<210>  62
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  62

Met Lys Lys Arg Thr Ser Ile Leu Leu Ala Ser Val Ala Met Leu Gly 
1               5                   10                  15      


Met Gly Ser Thr Ala Phe Ala Gln Val Asp Ile Asn Ala Leu Pro Ala 
            20                  25                  30          


Val Thr Asp Ala Ile Leu Ala Asn Pro Asp Ala Gly Asp Trp Pro Ser 
        35                  40                  45              


Tyr Gly Arg Asp Ile Thr Asn Tyr Arg Phe Ser Pro Leu Asp Gln Val 
    50                  55                  60                  


Asn Lys Asp Asn Val Gly Gln Leu Thr Leu Ala Trp Ala Arg Ala Leu 
65                  70                  75                  80  


Glu Pro Gly Asn Leu Gln Ser Ala Pro Leu Glu Phe Gly Gly Val Leu 
                85                  90                  95      


Phe Thr Ala Ala Pro Gly Asp Val Val Gln Ala Met Asp Ala Ala Thr 
            100                 105                 110         


Gly Gln Leu Ile Trp Glu Tyr Arg Arg Gln Leu Pro Asp Arg Ala Thr 
        115                 120                 125             


Leu Asn Ser Leu Gly Glu Asn Lys Arg Gly Ile Ala Leu Tyr Glu Asp 
    130                 135                 140                 


Lys Ile Tyr Val Ala Thr Trp Asp Asn Phe Ile Val Ala Leu Asp Ala 
145                 150                 155                 160 


Lys Thr Gly Gln Val Ala Trp Glu Ser Asp Arg Gly Gly Gly Ala Asp 
                165                 170                 175     


Leu Ile Ser Asn Thr Thr Gly Pro Ile Val Ala Asn Gly Val Val Val 
            180                 185                 190         


Ala Gly Ser Thr Cys Gln Phe Ser Glu Phe Gly Cys Tyr Val Thr Gly 
        195                 200                 205             


His Asp Ala Ala Thr Gly Glu Glu Leu Trp Arg Asn Asn Phe Ile Pro 
    210                 215                 220                 


Lys Lys Gly Glu Glu Gly Asp Asp Thr Trp Gly Asp Ser Thr Glu Asp 
225                 230                 235                 240 


Gln Arg Trp Met Thr Gly Ala Trp Gly Gln Met Thr Tyr Asp Pro Glu 
                245                 250                 255     


Leu Asp Leu Val Tyr Tyr Gly Ser Thr Gly Ala Gly Pro Ala Ala Glu 
            260                 265                 270         


Phe Gln Arg Asn Thr Val Gly Gly Thr Leu Phe Gly Ser Asn Thr Arg 
        275                 280                 285             


Phe Ala Val Lys Pro Lys Thr Gly Glu Ile Val Trp Arg His Gln Val 
    290                 295                 300                 


Leu Pro Arg Asp Asn Trp Asp Gln Glu Cys Thr Tyr Glu Met Val Pro 
305                 310                 315                 320 


Val Asp Ile Asp Ser Ala Pro Ala Ala Asp Met Glu Gly Leu Leu Ala 
                325                 330                 335     


Leu Gly Thr Ala Ala Pro Gly Lys Lys Arg Val Leu Thr Gly Val Pro 
            340                 345                 350         


Cys Lys Thr Gly Val Met Trp Gln Phe Asp Ala Gln Thr Gly Glu Phe 
        355                 360                 365             


Ile Tyr Ala Arg Asp Thr Val Gln Gln Thr Leu Ile Glu Ser Val Asp 
    370                 375                 380                 


Asn Thr Gly Leu Val Thr Val Asn Glu Ala Ala Ile Pro Thr Glu Val 
385                 390                 395                 400 


Asp Val Ala Thr Pro Met Cys Pro Thr Tyr Leu Gly Gly Arg Asp Trp 
                405                 410                 415     


Ser Pro Thr Ala Phe Asn Pro Thr Ser Lys Val Met Phe Val Pro Leu 
            420                 425                 430         


Thr Asn Met Cys Ala Asp Val Thr Val Leu Asp Gln Glu Pro Thr Gly 
        435                 440                 445             


Leu Asp Val Tyr Asn Thr Glu Leu Thr Tyr Lys Met Pro Glu Gly Val 
    450                 455                 460                 


Thr Asp Ala Gly Arg Ile Asp Ala Ile Asn Val Glu Thr Gly Lys Thr 
465                 470                 475                 480 


Leu Trp Ser Trp Thr Gln Gln Thr Pro Gln Tyr Ala Ser Ile Thr Ala 
                485                 490                 495     


Thr Ala Gly Gly Leu Ile Phe Thr Gly Gly Ala Asp Arg Arg Phe Lys 
            500                 505                 510         


Ala Ile Asp Gln Glu Thr Gly Glu Leu Val Trp Ser Val Thr Leu Gly 
        515                 520                 525             


Ser Arg Ala Thr Gly His Pro Ile Ser Tyr Glu Val Asp Gly Arg Gln 
    530                 535                 540                 


Tyr Ile Ala Ile Pro Ala Gly Gly Pro Gly Tyr Ala Thr Asp Leu Ile 
545                 550                 555                 560 


Thr Ala Ser Gly Ser Thr Val Asp Val Val Ser Gly Ser Asn Met Leu 
                565                 570                 575     


Tyr Val Phe Ala Leu Pro Glu Gln Lys Lys 
            580                 585     


<210>  63
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  63

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Asp Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Lys His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Asp Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Arg Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Glu Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  64
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  64

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Ile Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Leu Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Asp Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Lys Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Arg Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Val Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  65
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  65

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Leu Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Ile Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Asp Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Arg Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Lys Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Tyr Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Val Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  66
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  66

Met Asp Tyr Arg Phe Leu Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Thr Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Leu Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu His Gly Lys Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Ile Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Leu Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Lys Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Leu Tyr Asp Trp Asp Arg Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Phe Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Asn Phe Arg Asp Asn Leu Gly Ala Ala Glu Leu Arg Leu 
    290                 295                 300                 


Ser Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Ile Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  67
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  67

Met Asp Tyr Lys Tyr Ile Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Glu Ala Thr Arg Gln Leu Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Asp Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Leu Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  68
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  68

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Glu Ala Thr Arg Gln Leu Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Ala Gly Ala Glu Leu Lys Leu 
    290                 295                 300                 


Ser Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Leu Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  69
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  69

Met Asp Tyr Lys Tyr Ile Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Ile Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Gly Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Leu Gly Pro Tyr Ala Asp Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  70
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  70

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Glu Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  71
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  71

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Gly Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Ala Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Ser Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Leu Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  72
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  72

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Ile Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Ala Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  73
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  73

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Leu Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Gly Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  74
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  74

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Leu Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Leu Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  75
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  75

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Ile Arg Val Ser Val Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Leu Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Asp Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Leu Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  76
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  76

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Glu Ala Thr Arg Gln Leu Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Pro Ala Asp Leu Asp Leu Leu Gly Thr Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  77
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  77

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Glu Ala Thr Arg Gln Leu Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Val Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Gly Asn Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Leu Ser Thr Tyr Val Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  78
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  78

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Ile Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Ala Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Asp Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Gln Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Leu Leu Ser Thr Tyr Val Glu Asp Phe Lys 
            340                 345                 350         


Arg Gly 
        


<210>  79
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  79

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Glu Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Asn Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Ile Gly Thr Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  80
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  80

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Gly Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Asp Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Asp Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Pro Ala Asp Leu Asp Leu Leu Gly Thr Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  81
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  81

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Ile Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Ala Asn Asp Arg Leu Asp 
                325                 330                 335     


Pro Ala Asp Leu Asp Leu Leu Ser Thr Tyr Val Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  82
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  82

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Asp Ala Thr Arg Gln Leu Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Gly Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Thr Phe Thr Ala Gln Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Ile Gly Thr Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  83
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  83

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Leu Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Ile 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Pro Ala Asp Leu Asp Leu Leu Gly Thr Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  84
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  84

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Ala Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Asp Ala Thr Arg Gln Leu Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Gly Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Ala Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ser Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Asp Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Pro Ala Asp Leu Asp Leu Leu Gly Thr Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  85
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  85

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Asp Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Asp Ala Thr Arg Gln Ile Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu Gly Arg Arg Gln Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Gly Gly Gly Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Lys His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Asp Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Glu Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Leu Ser Thr Tyr Val Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  86
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  86

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Leu Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Ser Arg Asp Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Lys Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Val Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  87
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  87

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Asp Ala Thr Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Ile Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Ser Arg Asp Pro 
225                 230                 235                 240 


Pro Val Pro Asp Trp Asp Arg Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Glu Glu Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Tyr Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Gly Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Thr Asp Asp Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Gln Asp Arg Leu Gly 
                325                 330                 335     


Pro Ala Asp Gln Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  88
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  88

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Ile Arg Val Ser Thr Leu 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Pro Gln Ala Asp Ala Thr Arg Gln Ile Asp Ile Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Ala Leu Ala Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asp Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Ile Lys Thr Asp Val Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Ile Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Ser His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Ala Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Lys Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Ser Arg Glu Pro 
225                 230                 235                 240 


Pro Leu Pro Asp Trp Asp Arg Leu Tyr Asp Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Glu Arg Asp Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Phe Ala Leu Gly Arg Pro Gly Val Thr Ser Ala Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Asn Phe Arg Asp Asn Leu Gly Ala Ala Glu Leu Lys Leu 
    290                 295                 300                 


Ser Asp Asp Glu Arg Gln Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Leu Asp Leu Asp Leu Ile Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  89
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  89

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Gln Val Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Lys His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Ala Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Thr Gly Gly Pro Glu Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Ala Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Gly Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala His Leu Arg Leu 
    290                 295                 300                 


Thr Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Arg Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  90
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  90

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Ala Arg Gln Ile Asp Leu Cys Ile Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Ile Gly Val Ala Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Gln Lys Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Trp Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Ala Asp Asn Leu Ala Ala Ile His Leu Arg Leu 
    290                 295                 300                 


Thr Ser Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  91
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  91

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Ala Arg Gln Ile Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Ile Gly Gln Ala Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Arg Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Ala Gln Lys Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Tyr Ala Leu Gly Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Asn Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Arg Ile Val Asp Leu Asp Leu Glu Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  92
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  92

Met Asp Tyr Arg Phe Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Val Val Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Lys Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Leu Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Phe Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Asn Phe Ala Asp Asn Leu Ala Ala Ala His Leu Lys Leu 
    290                 295                 300                 


Ser Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Glu Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  93
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  93

Met Asp Tyr Lys Tyr Ile Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Ala Arg Gln Val Asp Ile Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Val Val Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Gly Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Ala Asp Asn Ile Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Gln Asp Arg Leu Ser 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Glu Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  94
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  94

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Gly Ala Thr Arg Gln Val Asp Ile Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Val Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Ala Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Gly Leu Ala Gly Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Leu Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Trp Ala Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Ala Asp Asn Ile Ala Gly Ala His Leu Lys Leu 
    290                 295                 300                 


Ser Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Gln Asp Arg Leu Ser 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  95
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  95

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Met Leu Gly Val Val Leu Ala Glu Asn Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Thr Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Ser Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Glu Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  96
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  96

Met Asp Tyr Lys Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Leu Gly Val Val Leu Ala Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Gly Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Ala Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Ile Leu Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Ala Asp Asn Ile Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Ser Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Glu Pro Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  97
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  97

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Thr Arg Gln Val Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Val Leu Ser Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Gly Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Asp Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Gly Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Asp Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Leu Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Trp Leu Leu Gly Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Ala Ala Ala His Leu Lys Leu 
    290                 295                 300                 


Ser Ser Asp Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Leu Glu Pro Tyr Ala Glu Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  98
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  98

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Lys Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp His Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Val Val Leu Ala Glu His Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Ile Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Ala Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Ile Ser Gln Gln Ile His Tyr Thr Leu His Ser Arg Glu Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ser 
            260                 265                 270         


Trp Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Ile Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Thr Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Asn Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  99
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  99

Met Asp Tyr Arg Tyr Leu Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Gly Gln Ala Gly Ala Ala Arg Gln Leu Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Val Val Leu Ser Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Gly Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Val Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Asp Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Lys Gln Ala Lys Val Arg Tyr Val Ala Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Gly Ala Asp Lys His His Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Ile Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Leu Ile Asp Val Ile Val 
                245                 250                 255     


Ala Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Arg Asp Asn Leu Ala Ala Ala His Leu Lys Leu 
    290                 295                 300                 


Thr Asp Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Ala Gln Asp Arg Leu Ser 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Glu Pro Tyr Ala Glu Asp Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  100
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  100

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Asp Leu Ala Gly Ala Thr Arg Gln Val Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Leu Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Glu Met Ile Gly Val Val Leu Ala Glu His Gly Arg Arg Gln Arg Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Arg Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Val Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Arg Thr Asp Ala Ile Glu Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Ala Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Gly Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Gly 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Asp Gly Gly Pro Asp Ala Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Asp Leu Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Arg Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Ala Leu Glu Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Ser Glu Ala Gln Phe Ala Asp Asn Leu Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Thr Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Asn Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


<210>  101
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  enzyme

<400>  101

Met Asp Tyr Arg Tyr Ile Gly Arg Ser Gly Leu Lys Val Ser Ala Met 
1               5                   10                  15      


Thr Met Gly Thr Met Thr Phe Gly Gly Ser Glu Arg Val Gly His Thr 
            20                  25                  30          


Ala Gln Ala Gly Ala Ala Arg Gln Val Asp Leu Cys Leu Asp Ala Gly 
        35                  40                  45              


Ile Asn Leu Tyr Asp Thr Ala Asn Val Tyr Asn Ala Gly Val Ser Glu 
    50                  55                  60                  


Asp Ile Leu Gly Val Val Leu Ser Glu Asn Gly Arg Arg Gln Lys Ala 
65                  70                  75                  80  


Leu Val Ala Thr Lys Val Arg Phe Lys Met Gly Asn Gly Pro Asn Glu 
                85                  90                  95      


Ala Gly Leu Ser Arg His His Ile Ile Ala Gln Ala Glu Ala Ser Leu 
            100                 105                 110         


Lys Arg Leu Lys Thr Asp Ala Ile Asp Leu Tyr Gln Val His Glu Trp 
        115                 120                 125             


Asp Gly Met Thr Pro Ile Glu Glu Thr Met Glu Ala Leu Asp Thr Leu 
    130                 135                 140                 


Val Arg Gln Gly Lys Val Arg Tyr Val Gly Cys Ser Asn Tyr Ser Gly 
145                 150                 155                 160 


Trp His Ile Met Lys Ala Leu Met Ala Ala Asp Lys Arg Gln Gly Gln 
                165                 170                 175     


Arg Phe Val Ser Gln Gln Ile His Tyr Ser Leu His Ser Arg Asp Ala 
            180                 185                 190         


Glu Tyr Glu Leu Val Pro Ile Ser Gln Asp Gln Gly Leu Gly Ile Leu 
        195                 200                 205             


Val Trp Ser Pro Leu Ala Gly Gly Leu Leu Ser Gly Lys Tyr Arg Arg 
    210                 215                 220                 


Thr Gly Gly Pro Glu Ser Gly Arg His Val Gly Gly Phe Arg Glu Pro 
225                 230                 235                 240 


Pro Val Tyr Asp Trp Asp Lys Leu Tyr Glu Leu Ile Asp Val Ile Val 
                245                 250                 255     


Asp Ile Ala Ala Gln Arg Gly Val Ser Gly Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Leu Leu Gly Arg Pro Gly Val Thr Ser Leu Ile Ile Gly Gly Arg 
        275                 280                 285             


Asn Glu Ala Gln Phe Arg Asp Asn Ile Ala Ala Ile His Leu Lys Leu 
    290                 295                 300                 


Ser Ser Glu Glu Arg Ala Arg Leu Asp Ala Ala Ser Arg Pro Pro Leu 
305                 310                 315                 320 


Leu Tyr Pro Tyr Trp His Gln Ser Phe Thr Gly Gln Asp Arg Leu Asp 
                325                 330                 335     


Gln Ile Asp Leu Asp Leu Ile Gly Pro Tyr Ala Asp Glu Phe Lys Arg 
            340                 345                 350         


Gly 
    


