               SEQUENCE LISTING

<110> SANOFI

<120> COMPOSITIONS AND METHODS FOR INHIBITING PCSK9

<130> BR87651

<150> EP19306036.5
<151> 2019-08-27

<160> 640

<170> BiSSAP 1.3.6

<210> 1
<211> 3731
<212> DNA
<213> Homo sapiens


<400> 1
gtccgatggg gctctggtgg cgtgatctgc gcgccccagg cgtcaagcac ccacacccta       60

gaaggtttcc gcagcgacgt cgaggcgctc atggttgcag gcgggcgccg ccgttcagtt      120

cagggtctga gcctggagga gtgagccagg cagtgagact ggctcgggcg ggccgggacg      180

cgtcgttgca gcagcggctc ccagctccca gccaggattc cgcgcgcccc ttcacgcgcc      240

ctgctcctga acttcagctc ctgcacagtc ctccccaccg caaggctcaa ggcgccgccg      300

gcgtggaccg cgcacggcct ctaggtctcc tcgccaggac agcaacctct cccctggccc      360

tcatgggcac cgtcagctcc aggcggtcct ggtggccgct gccactgctg ctgctgctgc      420

tgctgctcct gggtcccgcg ggcgcccgtg cgcaggagga cgaggacggc gactacgagg      480

agctggtgct agccttgcgt tccgaggagg acggcctggc cgaagcaccc gagcacggaa      540

ccacagccac cttccaccgc tgcgccaagg atccgtggag gttgcctggc acctacgtgg      600

tggtgctgaa ggaggagacc cacctctcgc agtcagagcg cactgcccgc cgcctgcagg      660

cccaggctgc ccgccgggga tacctcacca agatcctgca tgtcttccat ggccttcttc      720

ctggcttcct ggtgaagatg agtggcgacc tgctggagct ggccttgaag ttgccccatg      780

tcgactacat cgaggaggac tcctctgtct ttgcccagag catcccgtgg aacctggagc      840

ggattacccc tccacggtac cgggcggatg aataccagcc ccccgacgga ggcagcctgg      900

tggaggtgta tctcctagac accagcatac agagtgacca ccgggaaatc gagggcaggg      960

tcatggtcac cgacttcgag aatgtgcccg aggaggacgg gacccgcttc cacagacagg     1020

ccagcaagtg tgacagtcat ggcacccacc tggcaggggt ggtcagcggc cgggatgccg     1080

gcgtggccaa gggtgccagc atgcgcagcc tgcgcgtgct caactgccaa gggaagggca     1140

cggttagcgg caccctcata ggcctggagt ttattcggaa aagccagctg gtccagcctg     1200

tggggccact ggtggtgctg ctgcccctgg cgggtgggta cagccgcgtc ctcaacgccg     1260

cctgccagcg cctggcgagg gctggggtcg tgctggtcac cgctgccggc aacttccggg     1320

acgatgcctg cctctactcc ccagcctcag ctcccgaggt catcacagtt ggggccacca     1380

atgcccaaga ccagccggtg accctgggga ctttggggac caactttggc cgctgtgtgg     1440

acctctttgc cccaggggag gacatcattg gtgcctccag cgactgcagc acctgctttg     1500

tgtcacagag tgggacatca caggctgctg cccacgtggc tggcattgca gccatgatgc     1560

tgtctgccga gccggagctc accctggccg agttgaggca gagactgatc cacttctctg     1620

ccaaagatgt catcaatgag gcctggttcc ctgaggacca gcgggtactg acccccaacc     1680

tggtggccgc cctgcccccc agcacccatg gggcaggttg gcagctgttt tgcaggactg     1740

tatggtcagc acactcgggg cctacacgga tggccacagc cgtcgcccgc tgcgccccag     1800

atgaggagct gctgagctgc tccagtttct ccaggagtgg gaagcggcgg ggcgagcgca     1860

tggaggccca agggggcaag ctggtctgcc gggcccacaa cgcttttggg ggtgagggtg     1920

tctacgccat tgccaggtgc tgcctgctac cccaggccaa ctgcagcgtc cacacagctc     1980

caccagctga ggccagcatg gggacccgtg tccactgcca ccaacagggc cacgtcctca     2040

caggctgcag ctcccactgg gaggtggagg accttggcac ccacaagccg cctgtgctga     2100

ggccacgagg tcagcccaac cagtgcgtgg gccacaggga ggccagcatc cacgcttcct     2160

gctgccatgc cccaggtctg gaatgcaaag tcaaggagca tggaatcccg gcccctcagg     2220

agcaggtgac cgtggcctgc gaggagggct ggaccctgac tggctgcagt gccctccctg     2280

ggacctccca cgtcctgggg gcctacgccg tagacaacac gtgtgtagtc aggagccggg     2340

acgtcagcac tacaggcagc accagcgaag gggccgtgac agccgttgcc atctgctgcc     2400

ggagccggca cctggcgcag gcctcccagg agctccagtg acagccccat cccaggatgg     2460

gtgtctgggg agggtcaagg gctggggctg agctttaaaa tggttccgac ttgtccctct     2520

ctcagccctc catggcctgg cacgagggga tggggatgct tccgcctttc cggggctgct     2580

ggcctggccc ttgagtgggg cagcctcctt gcctggaact cactcactct gggtgcctcc     2640

tccccaggtg gaggtgccag gaagctccct ccctcactgt ggggcatttc accattcaaa     2700

caggtcgagc tgtgctcggg tgctgccagc tgctcccaat gtgccgatgt ccgtgggcag     2760

aatgactttt attgagctct tgttccgtgc caggcattca atcctcaggt ctccaccaag     2820

gaggcaggat tcttcccatg gataggggag ggggcggtag gggctgcagg gacaaacatc     2880

gttggggggt gagtgtgaaa ggtgctgatg gccctcatct ccagctaact gtggagaagc     2940

ccctgggggc tccctgatta atggaggctt agctttctgg atggcatcta gccagaggct     3000

ggagacaggt gcgcccctgg tggtcacagg ctgtgccttg gtttcctgag ccacctttac     3060

tctgctctat gccaggctgt gctagcaaca cccaaaggtg gcctgcgggg agccatcacc     3120

taggactgac tcggcagtgt gcagtggtgc atgcactgtc tcagccaacc cgctccacta     3180

cccggcaggg tacacattcg cacccctact tcacagagga agaaacctgg aaccagaggg     3240

ggcgtgcctg ccaagctcac acagcaggaa ctgagccaga aacgcagatt gggctggctc     3300

tgaagccaag cctcttctta cttcacccgg ctgggctcct catttttacg ggtaacagtg     3360

aggctgggaa ggggaacaca gaccaggaag ctcggtgagt gatggcagaa cgatgcctgc     3420

aggcatggaa ctttttccgt tatcacccag gcctgattca ctggcctggc ggagatgctt     3480

ctaaggcatg gtcgggggag agggccaaca actgtccctc cttgagcacc agccccaccc     3540

aagcaagcag acatttatct tttgggtctg tcctctctgt tgccttttta cagccaactt     3600

ttctagacct gttttgcttt tgtaacttga agatatttat tctgggtttt gtagcatttt     3660

tattaatatg gtgacttttt aaaataaaaa caaacaaacg ttgtcctaac aaaaaaaaaa     3720

aaaaaaaaaa a                                                          3731


<210> 2
<211> 48
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 2
uuguagcauu uuuauuaaua uggugacuuu uuaaaauaaa aacaaaca                  48


<210> 3
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 3
uuguagcauu uuuauuaau                                                 19


<210> 4
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 4
guagcauuuu uauuaauau                                                 19


<210> 5
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 5
gcauuuuuau uaauauggu                                                 19


<210> 6
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 6
uuuuauuaau auggugacu                                                 19


<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 7
uauuaauaug gugacuuuu                                                 19


<210> 8
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 8
auuaauaugg ugacuuuuu                                                 19


<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 9
uuaauauggu gacuuuuua                                                 19


<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 10
uaauauggug acuuuuuaa                                                 19


<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 11
uauggugacu uuuuaaaau                                                 19


<210> 12
<211> 30
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 12
gagugugaaa ggugcugaug gcccucaucu                                     30


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 13
gagugugaaa ggugcugau                                                 19


<210> 14
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 14
ccauuguagc auuuuuauua aut                                            23


<210> 15
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 15
auuaauaaaa augcuacaat t                                              21


<210> 16
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 16
ccauguagca uuuuuauuaa uat                                            23


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 17
uauuaauaaa aaugcuacat t                                              21


<210> 18
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 18
ccaguagcau uuuuauuaau aut                                            23


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 19
auauuaauaa aaaugcuact t                                              21


<210> 20
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 20
ccauagcauu uuuauuaaua ugt                                            23


<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 21
cauauuaaua aaaaugcuat t                                              21


<210> 22
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 22
ccaagcauuu uuauuaauau ggt                                            23


<210> 23
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 23
ccauauuaau aaaaaugcut t                                              21


<210> 24
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 24
ccagcauuuu uauuaauaug gut                                            23


<210> 25
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 25
accauauuaa uaaaaaugct t                                              21


<210> 26
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 26
ccauuuuuau uaauauggug act                                            23


<210> 27
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 27
gucaccauau uaauaaaaat t                                              21


<210> 28
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 28
ccauuuuauu aauaugguga cut                                            23


<210> 29
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 29
agucaccaua uuaauaaaat t                                              21


<210> 30
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 30
ccauuuauua auauggugac uut                                            23


<210> 31
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 31
aagucaccau auuaauaaat t                                              21


<210> 32
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 32
ccauauuaau auggugacuu uut                                            23


<210> 33
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 33
aaaagucacc auauuaauat t                                              21


<210> 34
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 34
ccaauuaaua uggugacuuu uut                                            23


<210> 35
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 35
aaaaagucac cauauuaaut t                                              21


<210> 36
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 36
ccauuaauau ggugacuuuu uat                                            23


<210> 37
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 37
uaaaaaguca ccauauuaat t                                              21


<210> 38
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 38
ccauaauaug gugacuuuuu aat                                            23


<210> 39
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 39
uuaaaaaguc accauauuat t                                              21


<210> 40
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 40
ccauauggug acuuuuuaaa aut                                            23


<210> 41
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 41
auuuuaaaaa gucaccauat t                                              21


<210> 42
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 42
ccaggcucug guggcgugau cut                                            23


<210> 43
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 43
agaucacgcc accagagcct t                                              21


<210> 44
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 44
ccagcucugg uggcgugauc ugt                                            23


<210> 45
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 45
cagaucacgc caccagagct t                                              21


<210> 46
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 46
ccacucuggu ggcgugaucu gct                                            23


<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 47
gcagaucacg ccaccagagt t                                              21


<210> 48
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 48
ccaucuggug gcgugaucug cgt                                            23


<210> 49
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 49
cgcagaucac gccaccagat t                                              21


<210> 50
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 50
ccacaggcgu caagcaccca cat                                            23


<210> 51
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 51
ugugggugcu ugacgccugt t                                              21


<210> 52
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 52
ccaaggcguc aagcacccac act                                            23


<210> 53
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 53
gugugggugc uugacgccut t                                              21


<210> 54
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 54
ccacgucaag cacccacacc cut                                            23


<210> 55
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 55
aggguguggg ugcuugacgt t                                              21


<210> 56
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 56
ccagucaagc acccacaccc uat                                            23


<210> 57
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 57
uagggugugg gugcuugact t                                              21


<210> 58
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 58
ccaucaagca cccacacccu agt                                            23


<210> 59
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 59
cuagggugug ggugcuugat t                                              21


<210> 60
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 60
ccacaagcac ccacacccua gat                                            23


<210> 61
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 61
ucuagggugu gggugcuugt t                                              21


<210> 62
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 62
ccaaagcacc cacacccuag aat                                            23


<210> 63
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 63
uucuagggug ugggugcuut t                                              21


<210> 64
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 64
ccaagcaccc acacccuaga agt                                            23


<210> 65
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 65
cuucuagggu gugggugcut t                                              21


<210> 66
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 66
ccagcaccca cacccuagaa ggt                                            23


<210> 67
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 67
ccuucuaggg ugugggugct t                                              21


<210> 68
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 68
ccacacccac acccuagaag gut                                            23


<210> 69
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 69
accuucuagg gugugggugt t                                              21


<210> 70
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 70
ccaacccaca cccuagaagg uut                                            23


<210> 71
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 71
aaccuucuag ggugugggut t                                              21


<210> 72
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 72
ccacccacac ccuagaaggu uut                                            23


<210> 73
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 73
aaaccuucua gggugugggt t                                              21


<210> 74
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 74
ccaccacacc cuagaagguu uct                                            23


<210> 75
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 75
gaaaccuucu aggguguggt t                                              21


<210> 76
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 76
ccacacaccc uagaagguuu cct                                            23


<210> 77
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 77
ggaaaccuuc uagggugugt t                                              21


<210> 78
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 78
ccaacacccu agaagguuuc cgt                                            23


<210> 79
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 79
cggaaaccuu cuagggugut t                                              21


<210> 80
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 80
ccacacccua gaagguuucc gct                                            23


<210> 81
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 81
gcggaaaccu ucuagggugt t                                              21


<210> 82
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 82
ccaacccuag aagguuuccg cat                                            23


<210> 83
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 83
ugcggaaacc uucuagggut t                                              21


<210> 84
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 84
ccacccuaga agguuuccgc agt                                            23


<210> 85
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 85
cugcggaaac cuucuagggt t                                              21


<210> 86
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 86
ccaccuagaa gguuuccgca gct                                            23


<210> 87
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 87
gcugcggaaa ccuucuaggt t                                              21


<210> 88
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 88
ccacuagaag guuuccgcag cgt                                            23


<210> 89
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 89
cgcugcggaa accuucuagt t                                              21


<210> 90
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 90
ccauagaagg uuuccgcagc gat                                            23


<210> 91
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 91
ucgcugcgga aaccuucuat t                                              21


<210> 92
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 92
ccaagaaggu uuccgcagcg act                                            23


<210> 93
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 93
gucgcugcgg aaaccuucut t                                              21


<210> 94
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 94
ccagaagguu uccgcagcga cgt                                            23


<210> 95
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 95
cgucgcugcg gaaaccuuct t                                              21


<210> 96
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 96
ccaaagguuu ccgcagcgac gut                                            23


<210> 97
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 97
acgucgcugc ggaaaccuut t                                              21


<210> 98
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 98
ccaagguuuc cgcagcgacg uct                                            23


<210> 99
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 99
gacgucgcug cggaaaccut t                                              21


<210> 100
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 100
ccaguuuccg cagcgacguc gat                                            23


<210> 101
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 101
ucgacgucgc ugcggaaact t                                              21


<210> 102
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 102
ccauuuccgc agcgacgucg agt                                            23


<210> 103
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 103
cucgacgucg cugcggaaat t                                              21


<210> 104
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 104
ccaccugaac uucagcuccu gct                                            23


<210> 105
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 105
gcaggagcug aaguucaggt t                                              21


<210> 106
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 106
ccacugaacu ucagcuccug cat                                            23


<210> 107
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 107
ugcaggagcu gaaguucagt t                                              21


<210> 108
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 108
ccaugaacuu cagcuccugc act                                            23


<210> 109
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 109
gugcaggagc ugaaguucat t                                              21


<210> 110
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 110
ccaggacagc aaccucuccc cut                                            23


<210> 111
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 111
aggggagagg uugcugucct t                                              21


<210> 112
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 112
ccagacagca accucucccc ugt                                            23


<210> 113
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 113
caggggagag guugcuguct t                                              21


<210> 114
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 114
ccaacagcaa ccucuccccu ggt                                            23


<210> 115
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 115
ccaggggaga gguugcugut t                                              21


<210> 116
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 116
ccaaugggca ccgucagcuc cat                                            23


<210> 117
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 117
uggagcugac ggugcccaut t                                              21


<210> 118
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 118
ccaggaugaa uaccagcccc cct                                            23


<210> 119
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 119
ggggggcugg uauucaucct t                                              21


<210> 120
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 120
ccagaugaau accagccccc cgt                                            23


<210> 121
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 121
cggggggcug guauucauct t                                              21


<210> 122
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 122
ccaaugaaua ccagcccccc gat                                            23


<210> 123
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 123
ucggggggcu gguauucaut t                                              21


<210> 124
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 124
ccacaagggg gcaagcuggu cut                                            23


<210> 125
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 125
agaccagcuu gcccccuugt t                                              21


<210> 126
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 126
ccaaaggggg caagcugguc ugt                                            23


<210> 127
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 127
cagaccagcu ugcccccuut t                                              21


<210> 128
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 128
ccauggaccc ugacuggcug cat                                            23


<210> 129
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 129
ugcagccagu caggguccat t                                              21


<210> 130
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 130
ccagacccug acuggcugca gut                                            23


<210> 131
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 131
acugcagcca gucaggguct t                                              21


<210> 132
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 132
ccaugacugg cugcagugcc cut                                            23


<210> 133
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 133
agggcacugc agccagucat t                                              21


<210> 134
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 134
ccaucuuccc auggauaggg gat                                            23


<210> 135
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 135
uccccuaucc augggaagat t                                              21


<210> 136
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 136
ccacuuccca uggauagggg agt                                            23


<210> 137
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 137
cuccccuauc caugggaagt t                                              21


<210> 138
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 138
ccauucccau ggauagggga ggt                                            23


<210> 139
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 139
ccuccccuau ccaugggaat t                                              21


<210> 140
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 140
ccaguagggg cugcagggac aat                                            23


<210> 141
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 141
uugucccugc agccccuact t                                              21


<210> 142
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 142
ccagagugug aaaggugcug aut                                            23


<210> 143
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 143
aucagcaccu uucacacuct t                                              21


<210> 144
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 144
ccaaguguga aaggugcuga ugt                                            23


<210> 145
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 145
caucagcacc uuucacacut t                                              21


<210> 146
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 146
ccagugugaa aggugcugau ggt                                            23


<210> 147
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 147
ccaucagcac cuuucacact t                                              21


<210> 148
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 148
ccaugugaaa ggugcugaug gct                                            23


<210> 149
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 149
gccaucagca ccuuucacat t                                              21


<210> 150
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 150
ccagugaaag gugcugaugg cct                                            23


<210> 151
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 151
ggccaucagc accuuucact t                                              21


<210> 152
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 152
ccagcugugc cuugguuucc ugt                                            23


<210> 153
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 153
caggaaacca aggcacagct t                                              21


<210> 154
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 154
ccaugugccu ugguuuccug agt                                            23


<210> 155
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 155
cucaggaaac caaggcacat t                                              21


<210> 156
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 156
ccaaacaccc aaagguggcc ugt                                            23


<210> 157
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 157
caggccaccu uuggguguut t                                              21


<210> 158
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 158
ccaacaccca aagguggccu gct                                            23


<210> 159
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 159
gcaggccacc uuugggugut t                                              21


<210> 160
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 160
ccagaagaaa ccuggaacca gat                                            23


<210> 161
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 161
ucugguucca gguuucuuct t                                              21


<210> 162
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 162
ccauuguagc auuuuuauua aut                                            23


<210> 163
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 163
auuaauaaaa augcuacaat t                                              21


<210> 164
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 164
ccauguagca uuuuuauuaa uat                                            23


<210> 165
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 165
uauuaauaaa aaugcuacat t                                              21


<210> 166
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 166
ccaguagcau uuuuauuaau aut                                            23


<210> 167
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 167
auauuaauaa aaaugcuact t                                              21


<210> 168
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 168
ccauagcauu uuuauuaaua ugt                                            23


<210> 169
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 169
cauauuaaua aaaaugcuat t                                              21


<210> 170
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 170
ccaagcauuu uuauuaauau ggt                                            23


<210> 171
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 171
ccauauuaau aaaaaugcut t                                              21


<210> 172
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 172
ccagcauuuu uauuaauaug gut                                            23


<210> 173
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 173
accauauuaa uaaaaaugct t                                              21


<210> 174
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 174
ccauuuuuau uaauauggug act                                            23


<210> 175
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 175
gucaccauau uaauaaaaat t                                              21


<210> 176
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 176
ccauuuuauu aauaugguga cut                                            23


<210> 177
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 177
agucaccaua uuaauaaaat t                                              21


<210> 178
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 178
ccauuuauua auauggugac uut                                            23


<210> 179
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 179
aagucaccau auuaauaaat t                                              21


<210> 180
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 180
ccauauuaau auggugacuu uut                                            23


<210> 181
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 181
aaaagucacc auauuaauat t                                              21


<210> 182
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 182
ccaauuaaua uggugacuuu uut                                            23


<210> 183
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 183
aaaaagucac cauauuaaut t                                              21


<210> 184
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 184
ccauuaauau ggugacuuuu uat                                            23


<210> 185
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 185
uaaaaaguca ccauauuaat t                                              21


<210> 186
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 186
ccauaauaug gugacuuuuu aat                                            23


<210> 187
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 187
uuaaaaaguc accauauuat t                                              21


<210> 188
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 188
ccauauggug acuuuuuaaa aut                                            23


<210> 189
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 189
auuuuaaaaa gucaccauat t                                              21


<210> 190
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 190
ccaggcucug guggcgugau cut                                            23


<210> 191
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 191
agaucacgcc accagagcct t                                              21


<210> 192
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 192
ccagcucugg uggcgugauc ugt                                            23


<210> 193
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 193
cagaucacgc caccagagct t                                              21


<210> 194
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 194
ccacucuggu ggcgugaucu gct                                            23


<210> 195
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 195
gcagaucacg ccaccagagt t                                              21


<210> 196
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 196
ccaucuggug gcgugaucug cgt                                            23


<210> 197
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 197
cgcagaucac gccaccagat t                                              21


<210> 198
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 198
ccacaggcgu caagcaccca cat                                            23


<210> 199
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 199
ugugggugcu ugacgccugt t                                              21


<210> 200
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 200
ccaaggcguc aagcacccac act                                            23


<210> 201
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 201
gugugggugc uugacgccut t                                              21


<210> 202
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 202
ccacgucaag cacccacacc cut                                            23


<210> 203
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 203
aggguguggg ugcuugacgt t                                              21


<210> 204
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 204
ccagucaagc acccacaccc uat                                            23


<210> 205
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 205
uagggugugg gugcuugact t                                              21


<210> 206
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 206
ccaucaagca cccacacccu agt                                            23


<210> 207
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 207
cuagggugug ggugcuugat t                                              21


<210> 208
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 208
ccacaagcac ccacacccua gat                                            23


<210> 209
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 209
ucuagggugu gggugcuugt t                                              21


<210> 210
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 210
ccaaagcacc cacacccuag aat                                            23


<210> 211
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 211
uucuagggug ugggugcuut t                                              21


<210> 212
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 212
ccaagcaccc acacccuaga agt                                            23


<210> 213
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 213
cuucuagggu gugggugcut t                                              21


<210> 214
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 214
ccagcaccca cacccuagaa ggt                                            23


<210> 215
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 215
ccuucuaggg ugugggugct t                                              21


<210> 216
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 216
ccacacccac acccuagaag gut                                            23


<210> 217
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 217
accuucuagg gugugggugt t                                              21


<210> 218
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 218
ccaacccaca cccuagaagg uut                                            23


<210> 219
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 219
aaccuucuag ggugugggut t                                              21


<210> 220
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 220
ccacccacac ccuagaaggu uut                                            23


<210> 221
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 221
aaaccuucua gggugugggt t                                              21


<210> 222
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 222
ccaccacacc cuagaagguu uct                                            23


<210> 223
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 223
gaaaccuucu aggguguggt t                                              21


<210> 224
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 224
ccacacaccc uagaagguuu cct                                            23


<210> 225
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 225
ggaaaccuuc uagggugugt t                                              21


<210> 226
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 226
ccaacacccu agaagguuuc cgt                                            23


<210> 227
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 227
cggaaaccuu cuagggugut t                                              21


<210> 228
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 228
ccacacccua gaagguuucc gct                                            23


<210> 229
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 229
gcggaaaccu ucuagggugt t                                              21


<210> 230
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 230
ccaacccuag aagguuuccg cat                                            23


<210> 231
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 231
ugcggaaacc uucuagggut t                                              21


<210> 232
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 232
ccacccuaga agguuuccgc agt                                            23


<210> 233
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 233
cugcggaaac cuucuagggt t                                              21


<210> 234
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 234
ccaccuagaa gguuuccgca gct                                            23


<210> 235
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 235
gcugcggaaa ccuucuaggt t                                              21


<210> 236
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 236
ccacuagaag guuuccgcag cgt                                            23


<210> 237
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 237
cgcugcggaa accuucuagt t                                              21


<210> 238
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 238
ccauagaagg uuuccgcagc gat                                            23


<210> 239
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 239
ucgcugcgga aaccuucuat t                                              21


<210> 240
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 240
ccaagaaggu uuccgcagcg act                                            23


<210> 241
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 241
gucgcugcgg aaaccuucut t                                              21


<210> 242
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 242
ccagaagguu uccgcagcga cgt                                            23


<210> 243
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 243
cgucgcugcg gaaaccuuct t                                              21


<210> 244
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 244
ccaaagguuu ccgcagcgac gut                                            23


<210> 245
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 245
acgucgcugc ggaaaccuut t                                              21


<210> 246
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 246
ccaagguuuc cgcagcgacg uct                                            23


<210> 247
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 247
gacgucgcug cggaaaccut t                                              21


<210> 248
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 248
ccaguuuccg cagcgacguc gat                                            23


<210> 249
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 249
ucgacgucgc ugcggaaact t                                              21


<210> 250
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 250
ccauuuccgc agcgacgucg agt                                            23


<210> 251
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 251
cucgacgucg cugcggaaat t                                              21


<210> 252
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 252
ccaccugaac uucagcuccu gct                                            23


<210> 253
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 253
gcaggagcug aaguucaggt t                                              21


<210> 254
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 254
ccacugaacu ucagcuccug cat                                            23


<210> 255
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 255
ugcaggagcu gaaguucagt t                                              21


<210> 256
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 256
ccaugaacuu cagcuccugc act                                            23


<210> 257
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 257
gugcaggagc ugaaguucat t                                              21


<210> 258
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 258
ccaggacagc aaccucuccc cut                                            23


<210> 259
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 259
aggggagagg uugcugucct t                                              21


<210> 260
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 260
ccagacagca accucucccc ugt                                            23


<210> 261
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 261
caggggagag guugcuguct t                                              21


<210> 262
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 262
ccaacagcaa ccucuccccu ggt                                            23


<210> 263
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 263
ccaggggaga gguugcugut t                                              21


<210> 264
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 264
ccaaugggca ccgucagcuc cat                                            23


<210> 265
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 265
uggagcugac ggugcccaut t                                              21


<210> 266
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 266
ccaggaugaa uaccagcccc cct                                            23


<210> 267
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 267
ggggggcugg uauucaucct t                                              21


<210> 268
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 268
ccagaugaau accagccccc cgt                                            23


<210> 269
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 269
cggggggcug guauucauct t                                              21


<210> 270
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 270
ccaaugaaua ccagcccccc gat                                            23


<210> 271
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 271
ucggggggcu gguauucaut t                                              21


<210> 272
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 272
ccacaagggg gcaagcuggu cut                                            23


<210> 273
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 273
agaccagcuu gcccccuugt t                                              21


<210> 274
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 274
ccaaaggggg caagcugguc ugt                                            23


<210> 275
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 275
cagaccagcu ugcccccuut t                                              21


<210> 276
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 276
ccauggaccc ugacuggcug cat                                            23


<210> 277
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 277
ugcagccagu caggguccat t                                              21


<210> 278
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 278
ccagacccug acuggcugca gut                                            23


<210> 279
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 279
acugcagcca gucaggguct t                                              21


<210> 280
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 280
ccaugacugg cugcagugcc cut                                            23


<210> 281
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 281
agggcacugc agccagucat t                                              21


<210> 282
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 282
ccaucuuccc auggauaggg gat                                            23


<210> 283
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 283
uccccuaucc augggaagat t                                              21


<210> 284
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 284
ccacuuccca uggauagggg agt                                            23


<210> 285
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 285
cuccccuauc caugggaagt t                                              21


<210> 286
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 286
ccauucccau ggauagggga ggt                                            23


<210> 287
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 287
ccuccccuau ccaugggaat t                                              21


<210> 288
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 288
ccaguagggg cugcagggac aat                                            23


<210> 289
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 289
uugucccugc agccccuact t                                              21


<210> 290
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 290
ccagagugug aaaggugcug aut                                            23


<210> 291
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 291
aucagcaccu uucacacuct t                                              21


<210> 292
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 292
ccaaguguga aaggugcuga ugt                                            23


<210> 293
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 293
caucagcacc uuucacacut t                                              21


<210> 294
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 294
ccagugugaa aggugcugau ggt                                            23


<210> 295
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 295
ccaucagcac cuuucacact t                                              21


<210> 296
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 296
ccaugugaaa ggugcugaug gct                                            23


<210> 297
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 297
gccaucagca ccuuucacat t                                              21


<210> 298
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 298
ccagugaaag gugcugaugg cct                                            23


<210> 299
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 299
ggccaucagc accuuucact t                                              21


<210> 300
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 300
ccagcugugc cuugguuucc ugt                                            23


<210> 301
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 301
caggaaacca aggcacagct t                                              21


<210> 302
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 302
ccaugugccu ugguuuccug agt                                            23


<210> 303
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 303
cucaggaaac caaggcacat t                                              21


<210> 304
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 304
ccaaacaccc aaagguggcc ugt                                            23


<210> 305
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 305
caggccaccu uuggguguut t                                              21


<210> 306
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 306
ccaacaccca aagguggccu gct                                            23


<210> 307
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 307
gcaggccacc uuugggugut t                                              21


<210> 308
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 308
ccagaagaaa ccuggaacca gat                                            23


<210> 309
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 309
ucugguucca gguuucuuct t                                              21


<210> 310
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 310
uuauuaauau ggugacuuu                                                 19


<210> 311
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 311
auauggugac uuuuuaaaa                                                 19


<210> 312
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 312
auuuuuauua auauggugac u                                              21


<210> 313
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 313
uuuuauuaau auggugacuu u                                              21


<210> 314
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 314
uuuauuaaua uggugacuuu u                                              21


<210> 315
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 315
uauuaauaug gugacuuuuu a                                              21


<210> 316
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 316
aauaugguga cuuuuuaaaa u                                              21


<210> 317
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 317
gcauuuuuau uaauauggug acu                                            23


<210> 318
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 318
auuuuuauua auauggugac uuu                                            23


<210> 319
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 319
uuuuuauuaa uauggugacu uuu                                            23


<210> 320
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 320
uuuauuaaua uggugacuuu uua                                            23


<210> 321
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 321
uuauuaauau ggugacuuuu uaa                                            23


<210> 322
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 322
ccauuauuaa uauggugacu uut                                            23


<210> 323
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 323
aaagucacca uauuaauaat t                                              21


<210> 324
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 324
ccaauauggu gacuuuuuaa aat                                            23


<210> 325
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 325
uuuuaaaaag ucaccauaut t                                              21


<210> 326
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 326
ccaauuuuua uuaauauggu gacut                                          25


<210> 327
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 327
agucaccaua uuaauaaaaa utt                                            23


<210> 328
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 328
ccauuuuauu aauaugguga cuuut                                          25


<210> 329
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 329
aaagucacca uauuaauaaa att                                            23


<210> 330
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 330
ccauuuauua auauggugac uuuut                                          25


<210> 331
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 331
aaaagucacc auauuaauaa att                                            23


<210> 332
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 332
ccauauuaau auggugacuu uuuat                                          25


<210> 333
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 333
uaaaaaguca ccauauuaau att                                            23


<210> 334
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 334
ccaaauaugg ugacuuuuua aaaut                                          25


<210> 335
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 335
auuuuaaaaa gucaccauau utt                                            23


<210> 336
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 336
ccagcauuuu uauuaauaug gugacut                                        27


<210> 337
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 337
agucaccaua uuaauaaaaa ugctt                                          25


<210> 338
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 338
ccaauuuuua uuaauauggu gacuuut                                        27


<210> 339
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 339
aaagucacca uauuaauaaa aautt                                          25


<210> 340
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 340
ccauuuuuau uaauauggug acuuuut                                        27


<210> 341
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 341
aaaagucacc auauuaauaa aaatt                                          25


<210> 342
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 342
ccauuuauua auauggugac uuuuuat                                        27


<210> 343
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 343
uaaaaaguca ccauauuaau aaatt                                          25


<210> 344
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 344
ccauuauuaa uauggugacu uuuuaat                                        27


<210> 345
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 345
uuaaaaaguc accauauuaa uaatt                                          25


<210> 346
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 346
ccauuauuaa uauggugacu uut                                            23


<210> 347
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 347
aaagucacca uauuaauaat t                                              21


<210> 348
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 348
ccaauauggu gacuuuuuaa aat                                            23


<210> 349
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 349
uuuuaaaaag ucaccauaut t                                              21


<210> 350
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 350
ccaauuuuua uuaauauggu gacut                                          25


<210> 351
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 351
agucaccaua uuaauaaaaa utt                                            23


<210> 352
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 352
ccauuuuauu aauaugguga cuuut                                          25


<210> 353
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 353
aaagucacca uauuaauaaa att                                            23


<210> 354
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 354
ccauuuauua auauggugac uuuut                                          25


<210> 355
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 355
aaaagucacc auauuaauaa att                                            23


<210> 356
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 356
ccauauuaau auggugacuu uuuat                                          25


<210> 357
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 357
uaaaaaguca ccauauuaau att                                            23


<210> 358
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 358
ccaaauaugg ugacuuuuua aaaut                                          25


<210> 359
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 359
auuuuaaaaa gucaccauau utt                                            23


<210> 360
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 360
ccagcauuuu uauuaauaug gugacut                                        27


<210> 361
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 361
agucaccaua uuaauaaaaa ugctt                                          25


<210> 362
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 362
ccaauuuuua uuaauauggu gacuuut                                        27


<210> 363
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 363
aaagucacca uauuaauaaa aautt                                          25


<210> 364
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 364
ccauuuuuau uaauauggug acuuuut                                        27


<210> 365
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 365
aaaagucacc auauuaauaa aaatt                                          25


<210> 366
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 366
ccauuuauua auauggugac uuuuuat                                        27


<210> 367
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 367
uaaaaaguca ccauauuaau aaatt                                          25


<210> 368
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 368
ccauuauuaa uauggugacu uuuuaat                                        27


<210> 369
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 369
uuaaaaaguc accauauuaa uaatt                                          25


<210> 370
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 370
auuaauaaaa augcuacaa                                                 19


<210> 371
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 371
auauuaauaa aaaugcuac                                                 19


<210> 372
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 372
accauauuaa uaaaaaugc                                                 19


<210> 373
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 373
agucaccaua uuaauaaaa                                                 19


<210> 374
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 374
aaaagucacc auauuaaua                                                 19


<210> 375
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 375
aaaaagucac cauauuaau                                                 19


<210> 376
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 376
uaaaaaguca ccauauuaa                                                 19


<210> 377
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 377
uuaaaaaguc accauauua                                                 19


<210> 378
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 378
auuuuaaaaa gucaccaua                                                 19


<210> 379
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 379
aucagcaccu uucacacuc                                                 19


<210> 380
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 380
aaagucacca uauuaauaa                                                 19


<210> 381
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 381
uuuuaaaaag ucaccauau                                                 19


<210> 382
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 382
agucaccaua uuaauaaaaa u                                              21


<210> 383
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 383
aaagucacca uauuaauaaa a                                              21


<210> 384
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 384
aaaagucacc auauuaauaa a                                              21


<210> 385
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 385
uaaaaaguca ccauauuaau a                                              21


<210> 386
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 386
auuuuaaaaa gucaccauau u                                              21


<210> 387
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 387
agucaccaua uuaauaaaaa ugc                                            23


<210> 388
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 388
aaagucacca uauuaauaaa aau                                            23


<210> 389
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 389
aaaagucacc auauuaauaa aaa                                            23


<210> 390
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 390
uaaaaaguca ccauauuaau aaa                                            23


<210> 391
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 391
uuaaaaaguc accauauuaa uaa                                            23


<210> 392
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 392
ccacaggaca gcaaccucuc cct                                            23


<210> 393
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 393
gggagagguu gcuguccugt t                                              21


<210> 394
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 394
ccaaggacag caaccucucc cct                                            23


<210> 395
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 395
ggggagaggu ugcuguccut t                                              21


<210> 396
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 396
ccaugccacu gcugcugcug cut                                            23


<210> 397
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 397
agcagcagca gcaguggcat t                                              21


<210> 398
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 398
ccacacugcu gcugcugcug cut                                            23


<210> 399
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 399
agcagcagca gcagcagugt t                                              21


<210> 400
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 400
ccaugcugcu gcugcugcuc cut                                            23


<210> 401
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 401
aggagcagca gcagcagcat t                                              21


<210> 402
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 402
ccaacccuga cuggcugcag ugt                                            23


<210> 403
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 403
cacugcagcc agucagggut t                                              21


<210> 404
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 404
ccaugaaagg ugcugauggc cct                                            23


<210> 405
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 405
gggccaucag caccuuucat t                                              21


<210> 406
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 406
ccaggcugug ccuugguuuc cut                                            23


<210> 407
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 407
aggaaaccaa ggcacagcct t                                              21


<210> 408
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 408
ccacugugcc uugguuuccu gat                                            23


<210> 409
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 409
ucaggaaacc aaggcacagt t                                              21


<210> 410
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 410
ccaggaagaa accuggaacc agt                                            23


<210> 411
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 411
cugguuccag guuucuucct t                                              21


<210> 412
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 412
ccaaagaaac cuggaaccag agt                                            23


<210> 413
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 413
cucugguucc agguuucuut t                                              21


<210> 414
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 414
ccaagaaacc uggaaccaga ggt                                            23


<210> 415
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 415
ccucugguuc cagguuucut t                                              21


<210> 416
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 416
ccaaaccugg aaccagaggg ggt                                            23


<210> 417
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 417
cccccucugg uuccagguut t                                              21


<210> 418
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 418
ccacauuuuu auuaauaugg ugt                                            23


<210> 419
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 419
caccauauua auaaaaaugt t                                              21


<210> 420
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 420
ccaauuuuua uuaauauggu gat                                            23


<210> 421
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 421
ucaccauauu aauaaaaaut t                                              21


<210> 422
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 422
ccaaauaugg ugacuuuuua aat                                            23


<210> 423
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 423
uuuaaaaagu caccauauut t                                              21


<210> 424
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 424
ccaauauggu gacuuuuuaa aat                                            23


<210> 425
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 425
uuuuaaaaag ucaccauaut t                                              21


<210> 426
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 426
ccaaugguga cuuuuuaaaa uat                                            23


<210> 427
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 427
uauuuuaaaa agucaccaut t                                              21


<210> 428
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 428
ccauggugac uuuuuaaaau aat                                            23


<210> 429
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 429
uuauuuuaaa aagucaccat t                                              21


<210> 430
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 430
ccaggugacu uuuuaaaaua aat                                            23


<210> 431
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 431
uuuauuuuaa aaagucacct t                                              21


<210> 432
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 432
ccagugacuu uuuaaaauaa aat                                            23


<210> 433
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 433
uuuuauuuua aaaagucact t                                              21


<210> 434
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 434
ccaugacuuu uuaaaauaaa aat                                            23


<210> 435
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 435
uuuuuauuuu aaaaagucat t                                              21


<210> 436
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 436
ccagacuuuu uaaaauaaaa act                                            23


<210> 437
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 437
guuuuuauuu uaaaaaguct t                                              21


<210> 438
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 438
ccaacuuuuu aaaauaaaaa cat                                            23


<210> 439
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 439
uguuuuuauu uuaaaaagut t                                              21


<210> 440
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 440
ccacuuuuua aaauaaaaac aat                                            23


<210> 441
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 441
uuguuuuuau uuuaaaaagt t                                              21


<210> 442
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 442
ccauuuuuaa aauaaaaaca aat                                            23


<210> 443
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 443
uuuguuuuua uuuuaaaaat t                                              21


<210> 444
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 444
ccauuuuaaa auaaaaacaa act                                            23


<210> 445
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 445
guuuguuuuu auuuuaaaat t                                              21


<210> 446
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 446
ccauuuaaaa uaaaaacaaa cat                                            23


<210> 447
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 447
uguuuguuuu uauuuuaaat t                                              21


<210> 448
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 448
ccacauuuuu auuaauaugg ugt                                            23


<210> 449
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 449
caccauauua auaaaaaugt t                                              21


<210> 450
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 450
ccaauuuuua uuaauauggu gat                                            23


<210> 451
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 451
ucaccauauu aauaaaaaut t                                              21


<210> 452
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 452
ccauuuuuau uaauauggug act                                            23


<210> 453
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 453
gucaccauau uaauaaaaat t                                              21


<210> 454
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 454
ccauuuauua auauggugac uut                                            23


<210> 455
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 455
aagucaccau auuaauaaat t                                              21


<210> 456
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 456
ccauuauuaa uauggugacu uut                                            23


<210> 457
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 457
aaagucacca uauuaauaat t                                              21


<210> 458
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 458
ccaaauaugg ugacuuuuua aat                                            23


<210> 459
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 459
uuuaaaaagu caccauauut t                                              21


<210> 460
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 460
ccagcauuuu uauuaauaug gugat                                          25


<210> 461
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 461
ucaccauauu aauaaaaaug ctt                                            23


<210> 462
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 462
ccacauuuuu auuaauaugg ugact                                          25


<210> 463
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 463
gucaccauau uaauaaaaau gtt                                            23


<210> 464
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 464
ccauuuuuau uaauauggug acuut                                          25


<210> 465
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 465
aagucaccau auuaauaaaa att                                            23


<210> 466
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 466
ccauuauuaa uauggugacu uuuut                                          25


<210> 467
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 467
aaaaagucac cauauuaaua att                                            23


<210> 468
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 468
ccaauuaaua uggugacuuu uuaat                                          25


<210> 469
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 469
uuaaaaaguc accauauuaa utt                                            23


<210> 470
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 470
ccauuaauau ggugacuuuu uaaat                                          25


<210> 471
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 471
uuuaaaaagu caccauauua att                                            23


<210> 472
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 472
ccauaauaug gugacuuuuu aaaat                                          25


<210> 473
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 473
uuuuaaaaag ucaccauauu att                                            23


<210> 474
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 474
ccacauuuuu auuaauaugg ugacuut                                        27


<210> 475
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 475
aagucaccau auuaauaaaa augtt                                          25


<210> 476
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 476
ccauuuuauu aauaugguga cuuuuut                                        27


<210> 477
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 477
aaaaagucac cauauuaaua aaatt                                          25


<210> 478
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 478
ccauauuaau auggugacuu uuuaaat                                        27


<210> 479
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 479
uuuaaaaagu caccauauua auatt                                          25


<210> 480
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 480
ccaauuaaua uggugacuuu uuaaaat                                        27


<210> 481
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 481
uuuuaaaaag ucaccauauu aautt                                          25


<210> 482
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 482
ccauuaauau ggugacuuuu uaaaaut                                        27


<210> 483
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 483
auuuuaaaaa gucaccauau uaatt                                          25


<210> 484
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 484
ccacaggaca gcaaccucuc cct                                            23


<210> 485
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 485
gggagagguu gcuguccugt t                                              21


<210> 486
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 486
ccaaggacag caaccucucc cct                                            23


<210> 487
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 487
ggggagaggu ugcuguccut t                                              21


<210> 488
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 488
ccaugccacu gcugcugcug cut                                            23


<210> 489
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 489
agcagcagca gcaguggcat t                                              21


<210> 490
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 490
ccacacugcu gcugcugcug cut                                            23


<210> 491
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 491
agcagcagca gcagcagugt t                                              21


<210> 492
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 492
ccaugcugcu gcugcugcuc cut                                            23


<210> 493
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 493
aggagcagca gcagcagcat t                                              21


<210> 494
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 494
ccaacccuga cuggcugcag ugt                                            23


<210> 495
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 495
cacugcagcc agucagggut t                                              21


<210> 496
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 496
ccaugaaagg ugcugauggc cct                                            23


<210> 497
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 497
gggccaucag caccuuucat t                                              21


<210> 498
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 498
ccaggcugug ccuugguuuc cut                                            23


<210> 499
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 499
aggaaaccaa ggcacagcct t                                              21


<210> 500
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 500
ccacugugcc uugguuuccu gat                                            23


<210> 501
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 501
ucaggaaacc aaggcacagt t                                              21


<210> 502
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 502
ccaggaagaa accuggaacc agt                                            23


<210> 503
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 503
cugguuccag guuucuucct t                                              21


<210> 504
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 504
ccaaagaaac cuggaaccag agt                                            23


<210> 505
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 505
cucugguucc agguuucuut t                                              21


<210> 506
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 506
ccaagaaacc uggaaccaga ggt                                            23


<210> 507
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 507
ccucugguuc cagguuucut t                                              21


<210> 508
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 508
ccaaaccugg aaccagaggg ggt                                            23


<210> 509
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 509
cccccucugg uuccagguut t                                              21


<210> 510
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 510
ccacauuuuu auuaauaugg ugt                                            23


<210> 511
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 511
caccauauua auaaaaaugt t                                              21


<210> 512
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 512
ccaauuuuua uuaauauggu gat                                            23


<210> 513
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 513
ucaccauauu aauaaaaaut t                                              21


<210> 514
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 514
ccaaauaugg ugacuuuuua aat                                            23


<210> 515
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 515
uuuaaaaagu caccauauut t                                              21


<210> 516
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 516
ccaauauggu gacuuuuuaa aat                                            23


<210> 517
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 517
uuuuaaaaag ucaccauaut t                                              21


<210> 518
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 518
ccaaugguga cuuuuuaaaa uat                                            23


<210> 519
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 519
uauuuuaaaa agucaccaut t                                              21


<210> 520
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 520
ccauggugac uuuuuaaaau aat                                            23


<210> 521
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 521
uuauuuuaaa aagucaccat t                                              21


<210> 522
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 522
ccaggugacu uuuuaaaaua aat                                            23


<210> 523
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 523
uuuauuuuaa aaagucacct t                                              21


<210> 524
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 524
ccagugacuu uuuaaaauaa aat                                            23


<210> 525
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 525
uuuuauuuua aaaagucact t                                              21


<210> 526
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 526
ccaugacuuu uuaaaauaaa aat                                            23


<210> 527
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 527
uuuuuauuuu aaaaagucat t                                              21


<210> 528
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 528
ccagacuuuu uaaaauaaaa act                                            23


<210> 529
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 529
guuuuuauuu uaaaaaguct t                                              21


<210> 530
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 530
ccaacuuuuu aaaauaaaaa cat                                            23


<210> 531
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 531
uguuuuuauu uuaaaaagut t                                              21


<210> 532
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 532
ccacuuuuua aaauaaaaac aat                                            23


<210> 533
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 533
uuguuuuuau uuuaaaaagt t                                              21


<210> 534
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 534
ccauuuuuaa aauaaaaaca aat                                            23


<210> 535
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 535
uuuguuuuua uuuuaaaaat t                                              21


<210> 536
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 536
ccauuuuaaa auaaaaacaa act                                            23


<210> 537
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 537
guuuguuuuu auuuuaaaat t                                              21


<210> 538
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 538
ccauuuaaaa uaaaaacaaa cat                                            23


<210> 539
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 539
uguuuguuuu uauuuuaaat t                                              21


<210> 540
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 540
ccacauuuuu auuaauaugg ugt                                            23


<210> 541
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 541
caccauauua auaaaaaugt t                                              21


<210> 542
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 542
ccaauuuuua uuaauauggu gat                                            23


<210> 543
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 543
ucaccauauu aauaaaaaut t                                              21


<210> 544
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 544
ccauuuuuau uaauauggug act                                            23


<210> 545
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 545
gucaccauau uaauaaaaat t                                              21


<210> 546
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 546
ccauuuuauu aauaugguga cut                                            23


<210> 547
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 547
agucaccaua uuaauaaaat t                                              21


<210> 548
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 548
ccauuuauua auauggugac uut                                            23


<210> 549
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 549
aagucaccau auuaauaaat t                                              21


<210> 550
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="Inverted DNA thymine"

<400> 550
ccaaauaugg ugacuuuuua aat                                            23


<210> 551
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 21
<223> /note="DNA thymine"

<400> 551
uuuaaaaagu caccauauut t                                              21


<210> 552
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 552
ccagcauuuu uauuaauaug gugat                                          25


<210> 553
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 553
ucaccauauu aauaaaaaug ctt                                            23


<210> 554
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 554
ccacauuuuu auuaauaugg ugact                                          25


<210> 555
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 555
gucaccauau uaauaaaaau gtt                                            23


<210> 556
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 556
ccauuuuuau uaauauggug acuut                                          25


<210> 557
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 557
aagucaccau auuaauaaaa att                                            23


<210> 558
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 558
ccauuauuaa uauggugacu uuuut                                          25


<210> 559
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 559
aaaaagucac cauauuaaua att                                            23


<210> 560
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 560
ccaauuaaua uggugacuuu uuaat                                          25


<210> 561
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 561
uuaaaaaguc accauauuaa utt                                            23


<210> 562
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 562
ccauuaauau ggugacuuuu uaaat                                          25


<210> 563
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 563
uuuaaaaagu caccauauua att                                            23


<210> 564
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="Inverted DNA thymine"

<400> 564
ccauaauaug gugacuuuuu aaaat                                          25


<210> 565
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 23
<223> /note="DNA thymine"

<400> 565
uuuuaaaaag ucaccauauu att                                            23


<210> 566
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 566
ccacauuuuu auuaauaugg ugacuut                                        27


<210> 567
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 567
aagucaccau auuaauaaaa augtt                                          25


<210> 568
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 568
ccauuuuauu aauaugguga cuuuuut                                        27


<210> 569
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 569
aaaaagucac cauauuaaua aaatt                                          25


<210> 570
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 570
ccauauuaau auggugacuu uuuaaat                                        27


<210> 571
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 571
uuuaaaaagu caccauauua auatt                                          25


<210> 572
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 572
ccaauuaaua uggugacuuu uuaaaat                                        27


<210> 573
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 573
uuuuaaaaag ucaccauauu aautt                                          25


<210> 574
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-Fluoro-guanosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 25
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 26
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 27
<223> /note="Inverted DNA thymine"

<400> 574
ccauuaauau ggugacuuuu uaaaaut                                        27


<210> 575
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<220> 
<221> misc_feature
<222> 1
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 2
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 3
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 4
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 5
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 6
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 7
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 8
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 9
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 10
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 11
<223> /note="2'-O-Methylguanosine"

<220> 
<221> misc_feature
<222> 12
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 13
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 14
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 15
<223> /note="2'-O-Methylcytidine"

<220> 
<221> misc_feature
<222> 16
<223> /note="2'-Fluoro-cytidine"

<220> 
<221> misc_feature
<222> 17
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 18
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 19
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 20
<223> /note="2'- fluoro-uridine"

<220> 
<221> misc_feature
<222> 21
<223> /note="2'-O-Methyluridine"

<220> 
<221> misc_feature
<222> 22
<223> /note="2'-fluoroadenosine"

<220> 
<221> misc_feature
<222> 23
<223> /note="2'-O-Methyladenosine"

<220> 
<221> misc_feature
<222> 24
<223> /note="DNA thymine"

<220> 
<221> misc_feature
<222> 25
<223> /note="DNA thymine"

<400> 575
auuuuaaaaa gucaccauau uaatt                                          25


<210> 576
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 576
uuuguagcau uuuuauuaau auggu                                          25


<210> 577
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Synthetic Construct

<400> 577
auuuuuauua auaugguga                                                 19


<210> 578
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 578
tttuauggug acuuuuuaaa au                                             22


<210> 579
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#01 to #05

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 579
tttuauggug acuuuuuaaa au                                             22


<210> 580
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#06 to #10

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a locked uracil (lU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 580
tttuauggug acuuuuuaaa au                                             22


<210> 581
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#11 to #19

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<400> 581
tttuauggug acuuuuuaaa tt                                             22


<210> 582
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#20 to #28

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 582
tttuauggug acuuuuuaaa tt                                             22


<210> 583
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#29 to #33

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a locked uracil (lU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<400> 583
tttuauggug acuuuuuaaa tt                                             22


<210> 584
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#34 to #38

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a locked uracil (lU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 584
tttuauggug acuuuuuaaa tt                                             22


<210> 585
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#39 to #47

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<400> 585
tttuauggug acuuuuuaaa autt                                           24


<210> 586
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#48 to #56

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<400> 586
tttuauggug acuuuuuaaa autt                                           24


<210> 587
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#57 to #61

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a locked uracil (lU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<400> 587
tttuauggug acuuuuuaaa autt                                           24


<210> 588
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> ss C027.001#62 to #66

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a locked uracil (lU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<400> 588
tttuauggug acuuuuuaaa autt                                           24


<210> 589
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a deoxythymidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a deoxythymidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 589
auuuuaaaaa gucaccauat t                                              21


<210> 590
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#01; #06; #11; #20; #29; #34; #39; #48; #57; #62

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 590
auuuuaaaaa gucaccauaa a                                              21


<210> 591
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#02; #07; #12; #21; #30; #35; #40; #49; #58; #63

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 591
auuuuaaaaa gucaccauaa a                                              21


<210> 592
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#03; #08; #13; #22; #31; #36; #41; #50; #59; #64

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 592
auuuuaaaaa gucaccauaa a                                              21


<210> 593
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#04; #09; #14; #23; #32; #37; #42; #51; #60; #65

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 593
auuuuaaaaa gucaccauaa a                                              21


<210> 594
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#05; #10; #15; #24; #33; #38; #43; #52; #61; #66

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a deoxythymidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a deoxythymidine"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 594
auuuuaaaaa gucaccauat t                                              21


<210> 595
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#16; #25; #44; #53

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 595
auuuuaaaaa gucaccauaa a                                              21


<210> 596
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#17; #26; #45; #54

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 596
auuuuaaaaa gucaccauaa a                                              21


<210> 597
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#18; #27; #46; #55

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 597
auuuuaaaaa gucaccauaa a                                              21


<210> 598
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> as C027.001#19; #28; #47; #56

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<400> 598
auuuuaaaaa gucaccauaa a                                              21


<210> 599
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.002

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 599
tttgcauuuu uauuaauaug gu                                             22


<210> 600
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#01; #02; #03; #04; #05

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 600
tttgcauuuu uauuaauaug gu                                             22


<210> 601
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#06; #07; #08; #09; #10

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a locked guanine (lG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a locked cytosine (lC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 601
tttgcauuuu uauuaauaug gu                                             22


<210> 602
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#11; #12; #13; #14; #15; #16; #17; #18; #19

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<400> 602
tttgcauuuu uauuaauaug tt                                             22


<210> 603
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#20; #21; #22; #23; #24; #25; #26; #27; #28

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 603
tttgcauuuu uauuaauaug tt                                             22


<210> 604
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#29; #30; #31; #32; #33

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a locked guanine (lG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a locked cytosine (lC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<400> 604
tttgcauuuu uauuaauaug tt                                             22


<210> 605
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#34; #35; #36; #37; #38

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a locked guanine (lG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a locked cytosine (lC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<400> 605
tttgcauuuu uauuaauaug tt                                             22


<210> 606
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#39; #40; #41; #42; #43; #44; #45; #46; #47

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<400> 606
tttgcauuuu uauuaauaug gutt                                           24


<210> 607
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#48; #49; #50; #51; #52; #53; #54; #55 #56

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<400> 607
tttgcauuuu uauuaauaug gutt                                           24


<210> 608
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#57; #58; #59; #60; #61

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a locked guanine (lG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a locked cytosine (lC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<400> 608
tttgcauuuu uauuaauaug gutt                                           24


<210> 609
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> forward C027.002#62; #63; #64; #65; #66

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a locked guanine (lG)"

<220> 
<221> misc_feature
<222> 5
<223> /note="C is a locked cytosine (lC)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<400> 609
tttgcauuuu uauuaauaug gutt                                           24


<210> 610
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.002

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a deoxythymidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a deoxythymidine"

<400> 610
accauauuaa uaaaaaugct t                                              21


<210> 611
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#01; #06; #11; #20; #29; #34; #39; #48; #57; #62

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<400> 611
accauauuaa uaaaaaugca a                                              21


<210> 612
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#02; #07; #12; #21; #30; #35; #40; #49; #58; #63

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<400> 612
accauauuaa uaaaaaugca a                                              21


<210> 613
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#03; #08; #13; #22; #31; #36; #41; #50; #59; #64

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<400> 613
accauauuaa uaaaaaugca a                                              21


<210> 614
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#04; #09; #14; #23; #32; #37; #42; #51; #60; #65

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<400> 614
accauauuaa uaaaaaugca a                                              21


<210> 615
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#05; #10; #15; #24; #33; #38; #43; #52; #61; #66

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a deoxythymidine"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a deoxythymidine"

<400> 615
accauauuaa uaaaaaugct t                                              21


<210> 616
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#16; #25; #44; #53

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<400> 616
accauauuaa uaaaaaugca a                                              21


<210> 617
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#17; #26; #45; #54

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<400> 617
accauauuaa uaaaaaugca a                                              21


<210> 618
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#18; #27; #46; #55

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<400> 618
accauauuaa uaaaaaugca a                                              21


<210> 619
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> reverse C027.002#19; #28; #47; #56

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="A is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<400> 619
accauauuaa uaaaaaugca a                                              21


<210> 620
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 620
tttuuauuaa uauggugacu uu                                             22


<210> 621
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#01,#02,#03,#04,#05

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 621
tttuuauuaa uauggugacu uu                                             22


<210> 622
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#06,#07,#08,#09,#10

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 622
tttttauuaa uauggugacu uu                                             22


<210> 623
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#11,#12,#13,#14,#15,#16,#17,#18,#19

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<400> 623
tttuuauuaa uauggugacu uu                                             22


<210> 624
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#20,#21,#22,#23,#24,#25,#26,#27,#28

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 624
tttuuauuaa uauggugacu uu                                             22


<210> 625
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#29,#30,#31,#32,#33

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<400> 625
tttttauuaa uauggugacu uu                                             22


<210> 626
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#34,#35,#36,#37,#38

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<400> 626
tttttauuaa uauggugacu uu                                             22


<210> 627
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#39,#40,#41,#42,#43,#44,#45,#46,#47

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<400> 627
tttuuauuaa uauggugacu uutt                                           24


<210> 628
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#48,#49,#50,#51,#52,#53,#54,#55,#56

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<400> 628
tttuuauuaa uauggugacu uutt                                           24


<210> 629
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#57,#58,#59,#60,#61

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<400> 629
tttttauuaa uauggugacu uutt                                           24


<210> 630
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> Forward C027.003#62,#63,#64,#65,#66

<220> 
<221> misc_feature
<222> 1
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 1
<223> /note="The nucleotide in position 1 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 1 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 2
<223> /note="The nucleotide in position 2 and the nucleotide in
      position 3 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="T is a lgT3 nucleotide analog"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 2 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 3
<223> /note="The nucleotide in position 3 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 3 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="The nucleotide in position 4 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 4
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 5
<223> /note="T is a locked thymidine (lT)"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 4 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 5
<223> /note="The nucleotide in position 5 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 5 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 6
<223> /note="The nucleotide in position 6 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position 7 and the nucleotide in
      position 6 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 7
<223> /note="The nucleotide in position7 and the nucleotide in position
      8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 7 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 8
<223> /note="The nucleotide in position 8 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 8 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 9
<223> /note="The nucleotide in position 9 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 9 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 10
<223> /note="The nucleotide in position 10 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="U is a 2'-fluoro-uridine (fU)"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 10 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 11
<223> /note="The nucleotide in position 11 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-fluoro-adenosine (fA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 11 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 12
<223> /note="The nucleotide in position 12 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 12 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 13
<223> /note="The nucleotide in position 13 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="G is a 2'-fluoro-guanosine (fG)"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 13 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 14
<223> /note="The nucleotide in position 14 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 14 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 15
<223> /note="The nucleotide in position 15 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 15 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 16
<223> /note="The nucleotide in position 16 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 16 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 17
<223> /note="The nucleotide in position 17 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 17 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 18
<223> /note="The nucleotide in position 18 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 18 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 19
<223> /note="The nucleotide in position 19 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 19 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 20
<223> /note="The nucleotide in position 20 and the nucleotide in
      position 21 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 20 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 21
<223> /note="The nucleotide in position 21 and the nucleotide in
      position 22 are linked through a phosphodiester linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="U is a 2'-O-Methyluridine (mU)"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 21 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 22
<223> /note="The nucleotide in position 22 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="T is a LT4 nucleotide analog"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 22 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 23
<223> /note="The nucleotide in position 23 and the nucleotide in
      position 24 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="The nucleotide in position 24 and the nucleotide in
      position 23 are linked through a phosphorothioate linkage"

<220> 
<221> misc_feature
<222> 24
<223> /note="T is a LT4 nucleotide analog"

<400> 630
tttttauuaa uauggugacu uutt                                           24


<210> 631
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003

<400> 631
aaagucacca uauuaauaat t                                              21


<210> 632
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #01,#06,#11,#20,#29,#34,#39,#48,#57,#62,

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 8
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<400> 632
aaagucacca uauuaauaat t                                              21


<210> 633
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #02,#07,#12,#21,#30,#35,#40,#49,#58,#63

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<400> 633
aaagucacca uauuaauaat t                                              21


<210> 634
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #03,#13,#22,#31,#36,#41,#50,#59,#64

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 9
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<400> 634
aaagucacca uauuaauaat t                                              21


<210> 635
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #04,#09,#14,#23,#32,#37,#42,#51,#60,#65

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 8
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 9
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a 2'-O-Methyladenosine (mA)"

<400> 635
aaagucacca uauuaauaat t                                              21


<210> 636
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #05,#10,#15,#24,#33,#38,#43,#52,#61,#66

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<400> 636
aaagucacca uauuaauaat t                                              21


<210> 637
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #16,#25,#44,#53

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 8
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<400> 637
aaagucacca uauuaauaat t                                              21


<210> 638
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #17,#26,#45,#54

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 4
<223> /note="G is a 2'-O-Methylguanosine (mG)"

<220> 
<221> misc_feature
<222> 8
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="A is a locked adenine (lA)"

<400> 638
aaagucacca uauuaauaat t                                              21


<210> 639
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #18,#27,#46,#55

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 9
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a locked adenine (lA)"

<400> 639
aaagucacca uauuaauaat t                                              21


<210> 640
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Reverse C027.003 - #19,#28,#47,#56

<220> 
<221> misc_feature
<222> 1
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 6
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 8
<223> /note="C is a 2'-O-Methylcytidine (mC)"

<220> 
<221> misc_feature
<222> 9
<223> /note="C is a 2'-fluoro-cytidine (fC)"

<220> 
<221> misc_feature
<222> 10
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 12
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 18
<223> /note="A is a 2'-O-Methyladenosine (mA)"

<220> 
<221> misc_feature
<222> 20
<223> /note="T is a locked adenine (lA)"

<220> 
<221> misc_feature
<222> 21
<223> /note="T is a locked adenine (lA)"

<400> 640
aaagucacca uauuaauaat t                                              21


