                         SEQUENCE LISTING

<110>  Syntex S.A.
       Abentin, Alejandro D.
 
<120>  RECOMBINANT CHORIONIC GONADOTROPIN, PROCEDURE FOR PREPARATION, 
       PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME

<130>  MOM 234048

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1063
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding NTP-BetaCTP-NTP-Alpha

<400>  1
atggagaccc tgcagggcct gctgctgtgg atgctgctga gcgtgggagg cgtgtgggct       60

ggcgatatcg gcctgaacat caccggcagc ggcctgaata tcacaggctc tggcctgaac      120

attaccggct ctggcctgaa tatcaccggc cctggctcta cagatatcag cagaggacca      180

ctgaggcctc tgtgccggcc tatcaacgcc accctggctg ctgagaagga ggcttgccca      240

atctgtatca cattcaccac aagcatctgc gccggctact gtccatccat ggtgcgcgtg      300

atgccagccg ctctgccagc tatccctcag ccagtgtgca cctatcggga gctgaggttc      360

gcttccatca ggctgccagg atgtccacct ggagtggacc ctatggtgtc ctttccagtg      420

gctctgtctt gccactgtgg cccctgccag atcaagacca cagactgtgg cgtgtttagg      480

gatcagccac tggcttgtgc tcctcaggct agctcctcta gcaaggatcc accctcccag      540

cccctgacca gcacatccac ccccacacct ggcgcttctc ggaggtcctc tcacccactg      600

cccatcaaga cctctggcag cggcctgaac atcacaggtt ctggcctgaa tattactggc      660

tctggcctga acatcaccgg ttccggcctg aatattaccg gcccaggctc cacatctttc      720

cccgacggcg agtttaccac acaggattgc cccgagtgta agctgaggga gaacaagtac      780

ttctttaagc tgggcgtgcc tatctatcag tgcaagggct gctgtttcag ccgggcctac      840

cctaccccag ctagaagccg caagacaatg ctggtgccta agaatatcac cagcgagtcc      900

acatgctgcg tggccaaggc ttttatccgg gtgaccgtga tgggcaacat caagctggag      960

aatcacaccc agtgctactg ttctacatgt tatcaccaca agatctgatt tcctgatgga     1020

gagtttacaa cgcaggattg cccagaaccc ccatcccaac ctc                       1063


<210>  2
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant  protein NTP-BetaCTP-NTP-Alpha

<400>  2

Met Glu Thr Leu Gln Gly Leu Leu Leu Trp Met Leu Leu Ser Val Gly 
1               5                   10                  15      


Gly Val Trp Ala Gly Asp Ile Gly Leu Asn Ile Thr Gly Ser Gly Leu 
            20                  25                  30          


Asn Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly Leu Asn Ile 
        35                  40                  45              


Thr Gly Pro Gly Ser Thr Asp Ile Ser Arg Gly Pro Leu Arg Pro Leu 
    50                  55                  60                  


Cys Arg Pro Ile Asn Ala Thr Leu Ala Ala Glu Lys Glu Ala Cys Pro 
65                  70                  75                  80  


Ile Cys Ile Thr Phe Thr Thr Ser Ile Cys Ala Gly Tyr Cys Pro Ser 
                85                  90                  95      


Met Val Arg Val Met Pro Ala Ala Leu Pro Ala Ile Pro Gln Pro Val 
            100                 105                 110         


Cys Thr Tyr Arg Glu Leu Arg Phe Ala Ser Ile Arg Leu Pro Gly Cys 
        115                 120                 125             


Pro Pro Gly Val Asp Pro Met Val Ser Phe Pro Val Ala Leu Ser Cys 
    130                 135                 140                 


His Cys Gly Pro Cys Gln Ile Lys Thr Thr Asp Cys Gly Val Phe Arg 
145                 150                 155                 160 


Asp Gln Pro Leu Ala Cys Ala Pro Gln Ala Ser Ser Ser Ser Lys Asp 
                165                 170                 175     


Pro Pro Ser Gln Pro Leu Thr Ser Thr Ser Thr Pro Thr Pro Gly Ala 
            180                 185                 190         


Ser Arg Arg Ser Ser His Pro Leu Pro Ile Lys Thr Ser Gly Ser Gly 
        195                 200                 205             


Leu Asn Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly Leu Asn 
    210                 215                 220                 


Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Pro Gly Ser Thr Ser Phe 
225                 230                 235                 240 


Pro Asp Gly Glu Phe Thr Thr Gln Asp Cys Pro Glu Cys Lys Leu Arg 
                245                 250                 255     


Glu Asn Lys Tyr Phe Phe Lys Leu Gly Val Pro Ile Tyr Gln Cys Lys 
            260                 265                 270         


Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Arg Lys 
        275                 280                 285             


Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys Cys Val 
    290                 295                 300                 


Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys Leu Glu 
305                 310                 315                 320 


Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys Ile 
                325                 330                 335 


<210>  3
<211>  1023
<212>  DNA
<213>  Nucleotide sequence encoding NTP-BetaCTP-CTP-Alpha

<400>  3
atggagaccc tgcagggcct gctgctgtgg atgctgctgt ctgtgggagg cgtgtgggct       60

ggcgatatcg gcctgaacat caccggctcc ggcctgaata tcacaggctc tggcctgaac      120

atcaccggaa gcggcctgaa tatcaccgga ccaggcagca cagatatctc ccggggacca      180

ctgaggcctc tgtgcagacc tatcaacgcc acactggccg ctgagaagga ggcttgccca      240

atctgtatca ccttcaccac atccatctgc gccggctact gtccttctat ggtgagagtg      300

atgccagccg ctctgccagc tatcccacag cccgtgtgca cctatagaga gctgcgcttc      360

gctagcatca gactgccagg atgtccacct ggagtggacc ctatggtgtc ttttccagtg      420

gctctgagct gccactgtgg cccctgccag atcaagacca cagactgtgg cgtgtttcgc      480

gatcagccac tggcttgtgc tcctcaggct agctcctcta gcaaggaccc accaagccag      540

ccactgacca gcacatccac cccaacaccc ggcgcttctc ggaggtcctc tcaccctctg      600

ccaatcaaga caagcgcccc ccaggcctct tcctctagca aggatcctcc atcccagcct      660

ctgacctcta caagcacccc aacacctgga gcttccagac gctcctctca cccactgccc      720

atcaagacct ctttcccaga cggcgagttt accacacagg attgccccga gtgtaagctg      780

cgcgagaaca agtacttctt taagctgggc gtgcctatct atcagtgcaa gggctgctgt      840

ttcagccggg cctaccctac accagctcgg tccaggaaga ccatgctggt gccaaagaat      900

atcacctccg agtctacatg ctgcgtggcc aaggctttta tccgggtgac cgtgatgggc      960

aacatcaagc tggagaatca cacccagtgc tactgttcca catgttatca ccacaagatc     1020

tga                                                                   1023


<210>  4
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant  protein NTP-BetaCTP-CTP-Alpha

<400>  4

Met Glu Thr Leu Gln Gly Leu Leu Leu Trp Met Leu Leu Ser Val Gly 
1               5                   10                  15      


Gly Val Trp Ala Gly Asp Ile Gly Leu Asn Ile Thr Gly Ser Gly Leu 
            20                  25                  30          


Asn Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly Leu Asn Ile 
        35                  40                  45              


Thr Gly Pro Gly Ser Thr Asp Ile Ser Arg Gly Pro Leu Arg Pro Leu 
    50                  55                  60                  


Cys Arg Pro Ile Asn Ala Thr Leu Ala Ala Glu Lys Glu Ala Cys Pro 
65                  70                  75                  80  


Ile Cys Ile Thr Phe Thr Thr Ser Ile Cys Ala Gly Tyr Cys Pro Ser 
                85                  90                  95      


Met Val Arg Val Met Pro Ala Ala Leu Pro Ala Ile Pro Gln Pro Val 
            100                 105                 110         


Cys Thr Tyr Arg Glu Leu Arg Phe Ala Ser Ile Arg Leu Pro Gly Cys 
        115                 120                 125             


Pro Pro Gly Val Asp Pro Met Val Ser Phe Pro Val Ala Leu Ser Cys 
    130                 135                 140                 


His Cys Gly Pro Cys Gln Ile Lys Thr Thr Asp Cys Gly Val Phe Arg 
145                 150                 155                 160 


Asp Gln Pro Leu Ala Cys Ala Pro Gln Ala Ser Ser Ser Ser Lys Asp 
                165                 170                 175     


Pro Pro Ser Gln Pro Leu Thr Ser Thr Ser Thr Pro Thr Pro Gly Ala 
            180                 185                 190         


Ser Arg Arg Ser Ser His Pro Leu Pro Ile Lys Thr Ser Ala Pro Gln 
        195                 200                 205             


Ala Ser Ser Ser Ser Lys Asp Pro Pro Ser Gln Pro Leu Thr Ser Thr 
    210                 215                 220                 


Ser Thr Pro Thr Pro Gly Ala Ser Arg Arg Ser Ser His Pro Leu Pro 
225                 230                 235                 240 


Ile Lys Thr Ser Phe Pro Asp Gly Glu Phe Thr Thr Gln Asp Cys Pro 
                245                 250                 255     


Glu Cys Lys Leu Arg Glu Asn Lys Tyr Phe Phe Lys Leu Gly Val Pro 
            260                 265                 270         


Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
        275                 280                 285             


Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu 
    290                 295                 300                 


Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly 
305                 310                 315                 320 


Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr 
                325                 330                 335     


His His Lys Ile 
            340 


<210>  5
<211>  906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding NTP-BetaCTP-Alpha

<400>  5
atggagaccc tgcagggcct gctgctgtgg atgctgctgt ccgtgggagg cgtgtgggct       60

ggcgatatcg gcctgaacat caccggctct ggcctgaata tcacaggatc tggcctgaac      120

attaccggat ccggcctgaa tatcaccggc cctggctcca cagatatcag ccggggacca      180

ctgaggcctc tgtgccggcc tatcaacgcc acactggccg ctgagaagga ggcttgccca      240

atctgtatca ccttcaccac atctatctgc gccggctact gtccaagcat ggtgcgcgtg      300

atgccagccg ctctgccagc tatccctcag ccagtgtgca cctatcggga gctgaggttc      360

gcttctatca ggctgccagg atgtccacct ggagtggacc ctatggtgag ctttccagtg      420

gctctgtcct gccactgtgg cccttgccag atcaagacca cagactgtgg cgtgtttagg      480

gatcagccac tggcttgtgc tcctcaggct agctcctcta gcaaggatcc acccagccag      540

cccctgacca gcacatccac cccaacacct ggagctagcc ggaggtcctc tcacccactg      600

cccatcaaga catccttccc agacggcgag tttaccacac aggattgccc cgagtgtaag      660

ctgagggaga acaagtactt ctttaagctg ggcgtgccaa tctatcagtg caagggctgc      720

tgtttctcca gagcctaccc tacaccagct agatctcgca agaccatgct ggtgcccaag      780

aatatcacct ctgagagcac atgctgcgtg gccaaggctt ttatccgggt gaccgtgatg      840

ggcaacatca agctggagaa tcacacccag tgctactgtt ctacatgtta tcaccacaag      900

atctga                                                                 906


<210>  6
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant  protein NTP-BetaCTP-Alpha

<400>  6

Met Glu Thr Leu Gln Gly Leu Leu Leu Trp Met Leu Leu Ser Val Gly 
1               5                   10                  15      


Gly Val Trp Ala Gly Asp Ile Gly Leu Asn Ile Thr Gly Ser Gly Leu 
            20                  25                  30          


Asn Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly Leu Asn Ile 
        35                  40                  45              


Thr Gly Pro Gly Ser Thr Asp Ile Ser Arg Gly Pro Leu Arg Pro Leu 
    50                  55                  60                  


Cys Arg Pro Ile Asn Ala Thr Leu Ala Ala Glu Lys Glu Ala Cys Pro 
65                  70                  75                  80  


Ile Cys Ile Thr Phe Thr Thr Ser Ile Cys Ala Gly Tyr Cys Pro Ser 
                85                  90                  95      


Met Val Arg Val Met Pro Ala Ala Leu Pro Ala Ile Pro Gln Pro Val 
            100                 105                 110         


Cys Thr Tyr Arg Glu Leu Arg Phe Ala Ser Ile Arg Leu Pro Gly Cys 
        115                 120                 125             


Pro Pro Gly Val Asp Pro Met Val Ser Phe Pro Val Ala Leu Ser Cys 
    130                 135                 140                 


His Cys Gly Pro Cys Gln Ile Lys Thr Thr Asp Cys Gly Val Phe Arg 
145                 150                 155                 160 


Asp Gln Pro Leu Ala Cys Ala Pro Gln Ala Ser Ser Ser Ser Lys Asp 
                165                 170                 175     


Pro Pro Ser Gln Pro Leu Thr Ser Thr Ser Thr Pro Thr Pro Gly Ala 
            180                 185                 190         


Ser Arg Arg Ser Ser His Pro Leu Pro Ile Lys Thr Ser Phe Pro Asp 
        195                 200                 205             


Gly Glu Phe Thr Thr Gln Asp Cys Pro Glu Cys Lys Leu Arg Glu Asn 
    210                 215                 220                 


Lys Tyr Phe Phe Lys Leu Gly Val Pro Ile Tyr Gln Cys Lys Gly Cys 
225                 230                 235                 240 


Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Arg Lys Thr Met 
                245                 250                 255     


Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys Cys Val Ala Lys 
            260                 265                 270         


Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys Leu Glu Asn His 
        275                 280                 285             


Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys Ile 
    290                 295                 300     


<210>  7
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding  NTP-Beta-NTP-Alpha

<400>  7
atggagaccc tgcagggcct gctgctgtgg atgctgctgt ccgtgggagg cgtgtgggct       60

ggcgatatcg gcctgaacat caccggctct ggcctgaata tcacaggatc tggcctgaac      120

attaccggat ccggcctgaa tatcaccggc cctggctcca cagatatctc tcggggacca      180

ctgaggcctc tgtgcagacc aatcaacgcc accctggccg ctgagaagga ggcttgcccc      240

atctgtatca cattcaccac aagcatctgc gccggctact gtccatccat ggtgagagtg      300

atgccagccg ctctgccagc tatcccacag cccgtgtgca cctatagaga gctgcgcttc      360

gcttctatca gactgccagg atgtccacct ggagtggacc ctatggtgag ctttccagtg      420

gccctgtcct gccactgtgg cccttgccag atcaagacca cagactgtgg cgtgtttcgc      480

gatcagccac tggcttgtgg ctctggcctg aacatcacag gcagtggcct gaatattacc      540

ggctccggcc tgaacattac cggttccggc ctgaatatta ctggaccagg cagcacatcc      600

ttccctgacg gcgagtttac cacacaggat tgccccgagt gtaagctgcg cgagaacaag      660

tacttcttta agctgggcgt gcctatctat cagtgcaagg gctgctgttt ctctcgggct      720

taccctaccc cagctcggag caggaagaca atgctggtgc ccaagaatat cacctctgag      780

agcacatgct gcgtggccaa ggcttttatc cgggtgaccg tgatgggcaa catcaagctg      840

gagaatcaca cccagtgcta ctgttccaca tgttatcacc acaagatctg a               891


<210>  8
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant  protein NTP-Beta-NTP-Alpha

<400>  8

Met Glu Thr Leu Gln Gly Leu Leu Leu Trp Met Leu Leu Ser Val Gly 
1               5                   10                  15      


Gly Val Trp Ala Gly Asp Ile Gly Leu Asn Ile Thr Gly Ser Gly Leu 
            20                  25                  30          


Asn Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly Leu Asn Ile 
        35                  40                  45              


Thr Gly Pro Gly Ser Thr Asp Ile Ser Arg Gly Pro Leu Arg Pro Leu 
    50                  55                  60                  


Cys Arg Pro Ile Asn Ala Thr Leu Ala Ala Glu Lys Glu Ala Cys Pro 
65                  70                  75                  80  


Ile Cys Ile Thr Phe Thr Thr Ser Ile Cys Ala Gly Tyr Cys Pro Ser 
                85                  90                  95      


Met Val Arg Val Met Pro Ala Ala Leu Pro Ala Ile Pro Gln Pro Val 
            100                 105                 110         


Cys Thr Tyr Arg Glu Leu Arg Phe Ala Ser Ile Arg Leu Pro Gly Cys 
        115                 120                 125             


Pro Pro Gly Val Asp Pro Met Val Ser Phe Pro Val Ala Leu Ser Cys 
    130                 135                 140                 


His Cys Gly Pro Cys Gln Ile Lys Thr Thr Asp Cys Gly Val Phe Arg 
145                 150                 155                 160 


Asp Gln Pro Leu Ala Cys Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly 
                165                 170                 175     


Leu Asn Ile Thr Gly Ser Gly Leu Asn Ile Thr Gly Ser Gly Leu Asn 
            180                 185                 190         


Ile Thr Gly Pro Gly Ser Thr Ser Phe Pro Asp Gly Glu Phe Thr Thr 
        195                 200                 205             


Gln Asp Cys Pro Glu Cys Lys Leu Arg Glu Asn Lys Tyr Phe Phe Lys 
    210                 215                 220                 


Leu Gly Val Pro Ile Tyr Gln Cys Lys Gly Cys Cys Phe Ser Arg Ala 
225                 230                 235                 240 


Tyr Pro Thr Pro Ala Arg Ser Arg Lys Thr Met Leu Val Pro Lys Asn 
                245                 250                 255     


Ile Thr Ser Glu Ser Thr Cys Cys Val Ala Lys Ala Phe Ile Arg Val 
            260                 265                 270         


Thr Val Met Gly Asn Ile Lys Leu Glu Asn His Thr Gln Cys Tyr Cys 
        275                 280                 285             


Ser Thr Cys Tyr His His Lys Ile 
    290                 295     


<210>  9
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding  CTP-Beta-CTP-CTP-Alpha

<400>  9
atggagaccc tgcagggcct gctgctgtgg atgctgctgt ccgtgggagg cgtgtgggct       60

ggcgtgttcc gggaccagcc tctggcttgc gctccacagg cttccagctc ttccaaggat      120

cccccttctc agccactgac ctctacatcc accccaacac caggagcttc caggcggagc      180

tctcaccctc tgccaatcaa gacctccagc agaggaccac tgaggcctct gtgcaggccc      240

atcaacgcca ccctggctgc tgagaaggag gcttgcccta tctgtatcac attcaccaca      300

tccatctgcg ctggctactg tcctagcatg gtgcgcgtga tgccagccgc tctgccagct      360

atcccacagc ccgtgtgcac ctatagggag ctgcggttcg ctagcatcag gctgcctgga      420

tgtccaccag gagtggaccc aatggtgagc tttcctgtgg ccctgtcttg ccattgtggc      480

ccatgccaga tcaagaccac agactgtggc gtgtttagag atcagccact ggcctgtgct      540

ccacaggctt cttccagctc taaggaccct ccaagccagc ccctgaccag cacatctacc      600

cctaccccag gagctagcag acgctccagc catccactgc caatcaagac ctctgcccct      660

caggcctctt ccagctctaa agacccccct tctcagcccc tgacctccac aagcacccca      720

acacctggag cttccaggcg gtccagccat ccactgccca tcaagacaag cttccctgac      780

ggcgagttta ccacacagga ttgcccagag tgtaagctgc gggagaacaa gtacttcttt      840

aagctgggcg tgcccatcta tcagtgcaag ggctgctgtt tctccagggc ctaccctacc      900

ccagctagat cccgcaagac aatgctggtg cctaagaata tcacctctga gtccacatgc      960

tgcgtggcca aggcttttat ccgcgtgacc gtgatgggca acatcaagct ggagaatcac     1020

acccagtgct actgttctac atgttatcac cataagatct ga                        1062


<210>  10
<211>  353
<212>  PRT
<213>  Recombinant  protein CTP-Beta-CTP-CTP-Alpha

<400>  10

Met Glu Thr Leu Gln Gly Leu Leu Leu Trp Met Leu Leu Ser Val Gly 
1               5                   10                  15      


Gly Val Trp Ala Gly Val Phe Arg Asp Gln Pro Leu Ala Cys Ala Pro 
            20                  25                  30          


Gln Ala Ser Ser Ser Ser Lys Asp Pro Pro Ser Gln Pro Leu Thr Ser 
        35                  40                  45              


Thr Ser Thr Pro Thr Pro Gly Ala Ser Arg Arg Ser Ser His Pro Leu 
    50                  55                  60                  


Pro Ile Lys Thr Ser Ser Arg Gly Pro Leu Arg Pro Leu Cys Arg Pro 
65                  70                  75                  80  


Ile Asn Ala Thr Leu Ala Ala Glu Lys Glu Ala Cys Pro Ile Cys Ile 
                85                  90                  95      


Thr Phe Thr Thr Ser Ile Cys Ala Gly Tyr Cys Pro Ser Met Val Arg 
            100                 105                 110         


Val Met Pro Ala Ala Leu Pro Ala Ile Pro Gln Pro Val Cys Thr Tyr 
        115                 120                 125             


Arg Glu Leu Arg Phe Ala Ser Ile Arg Leu Pro Gly Cys Pro Pro Gly 
    130                 135                 140                 


Val Asp Pro Met Val Ser Phe Pro Val Ala Leu Ser Cys His Cys Gly 
145                 150                 155                 160 


Pro Cys Gln Ile Lys Thr Thr Asp Cys Gly Val Phe Arg Asp Gln Pro 
                165                 170                 175     


Leu Ala Cys Ala Pro Gln Ala Ser Ser Ser Ser Lys Asp Pro Pro Ser 
            180                 185                 190         


Gln Pro Leu Thr Ser Thr Ser Thr Pro Thr Pro Gly Ala Ser Arg Arg 
        195                 200                 205             


Ser Ser His Pro Leu Pro Ile Lys Thr Ser Ala Pro Gln Ala Ser Ser 
    210                 215                 220                 


Ser Ser Lys Asp Pro Pro Ser Gln Pro Leu Thr Ser Thr Ser Thr Pro 
225                 230                 235                 240 


Thr Pro Gly Ala Ser Arg Arg Ser Ser His Pro Leu Pro Ile Lys Thr 
                245                 250                 255     


Ser Phe Pro Asp Gly Glu Phe Thr Thr Gln Asp Cys Pro Glu Cys Lys 
            260                 265                 270         


Leu Arg Glu Asn Lys Tyr Phe Phe Lys Leu Gly Val Pro Ile Tyr Gln 
        275                 280                 285             


Cys Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser 
    290                 295                 300                 


Arg Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys 
305                 310                 315                 320 


Cys Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys 
                325                 330                 335     


Leu Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys 
            340                 345                 350         


Ile 
    


<210>  11
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding  Beta-CTP-CTP-Alpha

<400>  11
atggagaccc tgcagggcct gctgctgtgg atgctgctgt ctgtgggagg cgtgtgggct       60

tccaggggac cactgcggcc tctgtgcaga cctatcaacg ccaccctggc cgctgagaag      120

gaggcttgcc caatctgtat cacattcacc acaagcatct gcgctggcta ctgtccctct      180

atggtgagag tgatgccagc cgctctgcca gctatcccac agcccgtgtg cacctataga      240

gagctgcgct tcgcttctat cagactgcca ggatgtccac ctggagtgga ccctatggtg      300

tcctttccag tggccctgag ctgccactgt ggaccatgcc agatcaagac cacagactgt      360

ggcgtgtttc gcgatcagcc actggcttgt gctcctcagg cttccagctc ttccaaggac      420

ccaccctccc agcctctgac ctccacaagc accccaacac ccggcgcttc taggcggagc      480

tctcaccctc tgccaatcaa gacctccgcc ccccaggcct ctagctcttc caaggatcct      540

ccaagccagc ctctgacctc tacatccacc cccacacctg gcgctagcag acgcagctct      600

catccactgc ccatcaagac atctttccca gacggcgagt ttaccacaca ggattgcccc      660

gagtgtaagc tgcgcgagaa caagtacttc tttaagctgg gcgtgcctat ctatcagtgc      720

aagggctgct gtttctccag ggcctaccct accccagcta ggagccggaa gacaatgctg      780

gtgccaaaga atatcaccag cgagtctaca tgctgcgtgg ccaaggcttt tatccgggtg      840

accgtgatgg gcaacatcaa gctggagaat catacccagt gctactgttc cacatgttat      900

caccataaga tctga                                                       915


<210>  12
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant  protein Beta-CTP-CTP-Alpha

<400>  12

Met Glu Thr Leu Gln Gly Leu Leu Leu Trp Met Leu Leu Ser Val Gly 
1               5                   10                  15      


Gly Val Trp Ala Ser Arg Gly Pro Leu Arg Pro Leu Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Ala Glu Lys Glu Ala Cys Pro Ile Cys Ile Thr 
        35                  40                  45              


Phe Thr Thr Ser Ile Cys Ala Gly Tyr Cys Pro Ser Met Val Arg Val 
    50                  55                  60                  


Met Pro Ala Ala Leu Pro Ala Ile Pro Gln Pro Val Cys Thr Tyr Arg 
65                  70                  75                  80  


Glu Leu Arg Phe Ala Ser Ile Arg Leu Pro Gly Cys Pro Pro Gly Val 
                85                  90                  95      


Asp Pro Met Val Ser Phe Pro Val Ala Leu Ser Cys His Cys Gly Pro 
            100                 105                 110         


Cys Gln Ile Lys Thr Thr Asp Cys Gly Val Phe Arg Asp Gln Pro Leu 
        115                 120                 125             


Ala Cys Ala Pro Gln Ala Ser Ser Ser Ser Lys Asp Pro Pro Ser Gln 
    130                 135                 140                 


Pro Leu Thr Ser Thr Ser Thr Pro Thr Pro Gly Ala Ser Arg Arg Ser 
145                 150                 155                 160 


Ser His Pro Leu Pro Ile Lys Thr Ser Ala Pro Gln Ala Ser Ser Ser 
                165                 170                 175     


Ser Lys Asp Pro Pro Ser Gln Pro Leu Thr Ser Thr Ser Thr Pro Thr 
            180                 185                 190         


Pro Gly Ala Ser Arg Arg Ser Ser His Pro Leu Pro Ile Lys Thr Ser 
        195                 200                 205             


Phe Pro Asp Gly Glu Phe Thr Thr Gln Asp Cys Pro Glu Cys Lys Leu 
    210                 215                 220                 


Arg Glu Asn Lys Tyr Phe Phe Lys Leu Gly Val Pro Ile Tyr Gln Cys 
225                 230                 235                 240 


Lys Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro Ala Arg Ser Arg 
                245                 250                 255     


Lys Thr Met Leu Val Pro Lys Asn Ile Thr Ser Glu Ser Thr Cys Cys 
            260                 265                 270         


Val Ala Lys Ala Phe Ile Arg Val Thr Val Met Gly Asn Ile Lys Leu 
        275                 280                 285             


Glu Asn His Thr Gln Cys Tyr Cys Ser Thr Cys Tyr His His Lys Ile 
    290                 295                 300                 


