                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> UBE3A FOR THE TREATMENT OF ANGELMAN SYNDROME

<130> 060933-1080

<140> PCT/US2020/047505
<141> 2020-08-21

<150> 62/945,062
<151> 2019-12-06

<150> 62/890,364
<151> 2019-08-22

<160> 35    

<170> PatentIn version 3.5

<210> 1
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
gcaaatgggc ggtaggcgtg tacggtggga ggtttatata agcagagctc gtttagtgaa       60

ccgtcagatc                                                              70


<210> 2
<211> 380
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
cattgattat tgactagtta ttaatagtaa tcaattacgg ggtcattagt tcatagccca       60

tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg accgcccaac      120

gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc aatagggact      180

ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa      240

gtgtatcata tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg      300

cattatgccc agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta      360

gtcatcgcta ttaccatggt                                                  380


<210> 3
<211> 559
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
cgattagtcc aatttgttaa agacaggata tcagtggtcc aggctctagt tttgactcaa       60

caatatcacc agctgaagcc tatagagtac gagccataga tagaataaaa gattttattt      120

agtctccaga aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctaggatca      180

aggttaggaa cagagagaca gcagaatatg ggccaaacag gatatctgtg gtaagcagtt      240

cctgccccgg ctcagggcca agaacagttg gaacagcaga atatgggcca aacaggatat      300

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt      360

cccgccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga      420

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg      480

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggcgc gatctagatc      540

tcgaatcgaa ttcgccctt                                                   559


<210> 4
<211> 511
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
taccgggtag gggaggcgct tttcccaagg cagtctggag catgcgcttt agcagccccg       60

ctggcacttg gcgctacaca agtggcctct ggcctcgcac acattccaca tccaccggta      120

ggcgccaacc ggctccgttc tttggtggcc ccttcgcgcc accttctact cctcccctag      180

tcaggaagtt cccccccgcc ccgcagctcg cgtcgtgcag gacgtgacaa atggaagtag      240

cacgtctcac tagtctcgtg cagatggaca gcaccgctga gcaatggaag cgggtaggcc      300

tttggggcag cggccaatag cagctttgct ccttcgcttt ctgggctcag aggctgggaa      360

ggggtgggtc cgggggcggg ctcaggggcg ggctcagggg cggggcgggc gcccgaaggt      420

cctccggagg cccggcattc tgcacgcttc aaaagcgcac gtctgccgcg ctgttctcct      480

cttcctcatc tccgggcctt tcgaccatct a                                     511


<210> 5
<211> 153
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctctat       60

ataagcagag ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt      120

gacctccata gaagacaccg actctagagg atc                                   153


<210> 6
<211> 546
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
aaggatctgc gatcgctccg gtgcccgtca gtgggcagag cgcacatcgc ccacagtccc       60

cgagaagttg gggggagggg tcggcaattg aacgggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagctgaag cttcgagggg ctcgcatctc tccttcacgc gcccgccgcc ctacctgagg      300

ccgccatcca cgccggttga gtcgcgttct gccgcctccc gcctgtggtg cctcctgaac      360

tgcgtccgcc gtctaggtaa gtttaaagct caggtcgaga ccgggccttt gtccggcgct      420

cccttggagc ctacctagac tcagccggct ctccacgctt tgcctgaccc tgcttgctca      480

actctacgtc tttgtttcgt tttctgttct gcgccgttac agatccaagc tgtgaccggc      540

gcctac                                                                 546


<210> 7
<211> 2559
<212> DNA
<213> Homo sapiens

<400> 7
atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc       60

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      120

gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      180

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gaaaggtgcc      240

cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa      300

gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga      360

gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg      420

gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca      480

aaagatgaag acaaagatga agatgaaaag gaaaaagctg catgttctgc tgctgctatg      540

gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat      600

ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac      660

accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg      720

tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat      780

ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga atatctggaa      840

atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa      900

ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt      960

cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa tctagtgaat     1020

gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta     1080

gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag     1140

tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct     1200

cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt     1260

atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat     1320

tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata     1380

ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt     1440

gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg     1500

agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc     1560

gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa     1620

ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc     1680

aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg gtttaatcca     1740

tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt     1800

tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg     1860

aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa     1920

gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca     1980

cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt     2040

ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat     2100

aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa     2160

tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg     2220

aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac     2280

tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga     2340

ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact aggaaaatta     2400

aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc     2460

tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg     2520

aaggccatca cgtatgccaa aggatttggc atgctgtaa                            2559


<210> 8
<211> 852
<212> PRT
<213> Homo sapiens

<400> 8
Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala 
            20                  25                  30          


Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro 
    50                  55                  60                  


Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala 
65                  70                  75                  80  


Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg 
                85                  90                  95      


Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu 
            100                 105                 110         


Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg 
        115                 120                 125             


Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe 
    130                 135                 140                 


Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala 
145                 150                 155                 160 


Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser 
                165                 170                 175     


Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly 
            180                 185                 190         


Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro Asp Asp 
        195                 200                 205             


Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu 
    210                 215                 220                 


Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu 
225                 230                 235                 240 


Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg 
                245                 250                 255     


Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn 
            260                 265                 270         


Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys 
        275                 280                 285             


Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu 
    290                 295                 300                 


Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe 
305                 310                 315                 320 


Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg 
                325                 330                 335     


Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu 
            340                 345                 350         


Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn 
        355                 360                 365             


His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu 
    370                 375                 380                 


Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro 
385                 390                 395                 400 


Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys 
                405                 410                 415     


Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn 
            420                 425                 430         


Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr 
        435                 440                 445             


Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val 
    450                 455                 460                 


Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu 
                485                 490                 495     


Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp 
            500                 505                 510         


Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu 
        515                 520                 525             


Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu 
    530                 535                 540                 


Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe 
545                 550                 555                 560 


Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys Leu Phe 
                565                 570                 575     


Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile 
            580                 585                 590         


Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val 
        595                 600                 605             


His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr 
    610                 615                 620                 


Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys 
625                 630                 635                 640 


Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr 
                645                 650                 655     


Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp 
            660                 665                 670         


Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys 
        675                 680                 685             


Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu 
    690                 695                 700                 


Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu 
705                 710                 715                 720 


Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile 
                725                 730                 735     


Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu 
            740                 745                 750         


Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp 
        755                 760                 765             


Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln 
    770                 775                 780                 


Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu 
785                 790                 795                 800 


Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr 
                805                 810                 815     


Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys 
            820                 825                 830         


Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly 
        835                 840                 845             


Phe Gly Met Leu 
    850         


<210> 9
<211> 2628
<212> DNA
<213> Homo sapiens

<400> 9
atggagaagc tgcaccagtg ttattggaaa tcaggagaac ctcagtctga cgacattgaa       60

gctagccgaa tgaagcgagc agctgcaaag catctaatag aacgctacta ccaccagtta      120

actgagggct gtggaaatga agcctgcacg aatgagtttt gtgcttcctg tccaactttt      180

cttcgtatgg ataataatgc agcagctatt aaagccctcg agctttataa gattaatgca      240

aaactctgtg atcctcatcc ctccaagaaa ggagcaagct cagcttacct tgagaactcg      300

aaaggtgccc ccaacaactc ctgctctgag ataaaaatga acaagaaagg cgctagaatt      360

gattttaaag atgtgactta cttaacagaa gagaaggtat atgaaattct tgaattatgt      420

agagaaagag aggattattc ccctttaatc cgtgttattg gaagagtttt ttctagtgct      480

gaggcattgg tacagagctt ccggaaagtt aaacaacaca ccaaggaaga actgaaatct      540

cttcaagcaa aagatgaaga caaagatgaa gatgaaaagg aaaaagctgc atgttctgct      600

gctgctatgg aagaagactc agaagcatct tcctcaagga taggtgatag ctcacaggga      660

gacaacaatt tgcaaaaatt aggccctgat gatgtgtctg tggatattga tgccattaga      720

agggtctaca ccagattgct ctctaatgaa aaaattgaaa ctgcctttct caatgcactt      780

gtatatttgt cacctaacgt ggaatgtgac ttgacgtatc acaatgtata ctctcgagat      840

cctaattatc tgaatttgtt cattatcgta atggagaata gaaatctcca cagtcctgaa      900

tatctggaaa tggctttgcc attattttgc aaagcgatga gcaagctacc ccttgcagcc      960

caaggaaaac tgatcagact gtggtctaaa tacaatgcag accagattcg gagaatgatg     1020

gagacatttc agcaacttat tacttataaa gtcataagca atgaatttaa cagtcgaaat     1080

ctagtgaatg atgatgatgc cattgttgct gcttcgaagt gcttgaaaat ggtttactat     1140

gcaaatgtag tgggagggga agtggacaca aatcacaatg aagaagatga tgaagagccc     1200

atccctgagt ccagcgagct gacacttcag gaacttttgg gagaagaaag aagaaacaag     1260

aaaggtcctc gagtggaccc cctggaaact gaacttggtg ttaaaaccct ggattgtcga     1320

aaaccactta tcccttttga agagtttatt aatgaaccac tgaatgaggt tctagaaatg     1380

gataaagatt atactttttt caaagtagaa acagagaaca aattctcttt tatgacatgt     1440

ccctttatat tgaatgctgt cacaaagaat ttgggattat attatgacaa tagaattcgc     1500

atgtacagtg aacgaagaat cactgttctc tacagcttag ttcaaggaca gcagttgaat     1560

ccatatttga gactcaaagt tagacgtgac catatcatag atgatgcact tgtccggcta     1620

gagatgatcg ctatggaaaa tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa     1680

ggagaacaag gagttgatga gggaggtgtt tccaaagaat tttttcagct ggttgtggag     1740

gaaatcttca atccagatat tggtatgttc acatacgatg aatctacaaa attgttttgg     1800

tttaatccat cttcttttga aactgagggt cagtttactc tgattggcat agtactgggt     1860

ctggctattt acaataactg tatactggat gtacattttc ccatggttgt ctacaggaag     1920

ctaatgggga aaaaaggaac ttttcgtgac ttgggagact ctcacccagt tctatatcag     1980

agtttaaaag atttattgga gtatgaaggg aatgtggaag atgacatgat gatcactttc     2040

cagatatcac agacagatct ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt     2100

gataaaattc caattacaaa tgaaaacagg aaggaatttg tcaatcttta ttctgactac     2160

attctcaata aatcagtaga aaaacagttc aaggcttttc ggagaggttt tcatatggtg     2220

accaatgaat ctcccttaaa gtacttattc agaccagaag aaattgaatt gcttatatgt     2280

ggaagccgga atctagattt ccaagcacta gaagaaacta cagaatatga cggtggctat     2340

accagggact ctgttctgat tagggagttc tgggaaatcg ttcattcatt tacagatgaa     2400

cagaaaagac tcttcttgca gtttacaacg ggcacagaca gagcacctgt gggaggacta     2460

ggaaaattaa agatgattat agccaaaaat ggcccagaca cagaaaggtt acctacatct     2520

catacttgct ttaatgtgct tttacttccg gaatactcaa gcaaagaaaa acttaaagag     2580

agattgttga aggccatcac gtatgccaaa ggatttggca tgctgtaa                  2628


<210> 10
<211> 875
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly Glu Pro Gln Ser 
1               5                   10                  15      


Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu 
            20                  25                  30          


Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala 
        35                  40                  45              


Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp 
    50                  55                  60                  


Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala 
65                  70                  75                  80  


Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr 
                85                  90                  95      


Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys 
            100                 105                 110         


Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu 
        115                 120                 125             


Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu 
    130                 135                 140                 


Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala 
145                 150                 155                 160 


Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu 
                165                 170                 175     


Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu 
            180                 185                 190         


Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu 
        195                 200                 205             


Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu 
    210                 215                 220                 


Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg 
225                 230                 235                 240 


Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe 
                245                 250                 255     


Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr 
            260                 265                 270         


Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile 
        275                 280                 285             


Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met 
    290                 295                 300                 


Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala 
305                 310                 315                 320 


Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile 
                325                 330                 335     


Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile 
            340                 345                 350         


Ser Asn Glu Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile 
        355                 360                 365             


Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val 
    370                 375                 380                 


Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro 
385                 390                 395                 400 


Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu 
                405                 410                 415     


Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu 
            420                 425                 430         


Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu 
        435                 440                 445             


Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr 
    450                 455                 460                 


Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys 
465                 470                 475                 480 


Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp 
                485                 490                 495     


Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser 
            500                 505                 510         


Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg 
        515                 520                 525             


Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala 
    530                 535                 540                 


Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu 
545                 550                 555                 560 


Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln 
                565                 570                 575     


Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr 
            580                 585                 590         


Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr 
        595                 600                 605             


Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr 
    610                 615                 620                 


Asn Asn Cys Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys 
625                 630                 635                 640 


Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro 
                645                 650                 655     


Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val 
            660                 665                 670         


Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe 
        675                 680                 685             


Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro 
    690                 695                 700                 


Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr 
705                 710                 715                 720 


Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly 
                725                 730                 735     


Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro 
            740                 745                 750         


Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln 
        755                 760                 765             


Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser 
    770                 775                 780                 


Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu 
785                 790                 795                 800 


Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro 
                805                 810                 815     


Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro 
            820                 825                 830         


Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu 
        835                 840                 845             


Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys 
    850                 855                 860                 


Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870                 875 


<210> 11
<211> 2619
<212> DNA
<213> Homo sapiens

<400> 11
atggccacag cttgtaaaag atcaggagaa cctcagtctg acgacattga agctagccga       60

atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc      120

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      180

gataataatg cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      240

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gaaaggtgcc      300

cccaacaact cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa      360

gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga      420

gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg      480

gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca      540

aaagatgaag acaaagatga agatgaaaag gaaaaagctg catgttctgc tgctgctatg      600

gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat      660

ttgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac      720

accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg      780

tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat      840

ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga atatctggaa      900

atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa      960

ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt     1020

cagcaactta ttacttataa agtcataagc aatgaattta acagtcgaaa tctagtgaat     1080

gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta     1140

gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag     1200

tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct     1260

cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt     1320

atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat     1380

tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata     1440

ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt     1500

gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg     1560

agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc     1620

gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa     1680

ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc     1740

aatccagata ttggtatgtt cacatacgat gaatctacaa aattgttttg gtttaatcca     1800

tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt     1860

tacaataact gtatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg     1920

aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa     1980

gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca     2040

cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt     2100

ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat     2160

aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa     2220

tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg     2280

aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac     2340

tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga     2400

ctcttcttgc agtttacaac gggcacagac agagcacctg tgggaggact aggaaaatta     2460

aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc     2520

tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg     2580

aaggccatca cgtatgccaa aggatttggc atgctgtaa                            2619


<210> 12
<211> 872
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Thr Ala Cys Lys Arg Ser Gly Glu Pro Gln Ser Asp Asp Ile 
1               5                   10                  15      


Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg 
            20                  25                  30          


Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn 
        35                  40                  45              


Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala 
    50                  55                  60                  


Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys 
65                  70                  75                  80  


Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn 
                85                  90                  95      


Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys 
            100                 105                 110         


Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu 
        115                 120                 125             


Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser 
    130                 135                 140                 


Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu 
145                 150                 155                 160 


Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys 
                165                 170                 175     


Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys 
            180                 185                 190         


Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser 
        195                 200                 205             


Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu 
    210                 215                 220                 


Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr 
225                 230                 235                 240 


Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala 
                245                 250                 255     


Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn 
            260                 265                 270         


Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met 
        275                 280                 285             


Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro 
    290                 295                 300                 


Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys 
305                 310                 315                 320 


Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met 
                325                 330                 335     


Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu 
            340                 345                 350         


Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala 
        355                 360                 365             


Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu 
    370                 375                 380                 


Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu 
385                 390                 395                 400 


Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn 
                405                 410                 415     


Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
            420                 425                 430         


Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn 
        435                 440                 445             


Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe 
    450                 455                 460                 


Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile 
465                 470                 475                 480 


Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile 
                485                 490                 495     


Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln 
            500                 505                 510         


Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His 
        515                 520                 525             


Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn 
    530                 535                 540                 


Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln 
545                 550                 555                 560 


Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val 
                565                 570                 575     


Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser 
            580                 585                 590         


Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln 
        595                 600                 605             


Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys 
    610                 615                 620                 


Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly 
625                 630                 635                 640 


Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr 
                645                 650                 655     


Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp 
            660                 665                 670         


Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro 
        675                 680                 685             


Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn 
    690                 695                 700                 


Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn 
705                 710                 715                 720 


Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met 
                725                 730                 735     


Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile 
            740                 745                 750         


Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu 
        755                 760                 765             


Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile 
    770                 775                 780                 


Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg 
785                 790                 795                 800 


Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly 
                805                 810                 815     


Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu 
            820                 825                 830         


Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu 
        835                 840                 845             


Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr 
    850                 855                 860                 


Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870         


<210> 13
<211> 2619
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc      120

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      180

gataataata cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      240

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gacaggtgcc      300

cccaacaaca cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa      360

gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga      420

gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg      480

gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca      540

aaagatgaag acaaagatga agatgaaaag gaaaaagctg catgttctgc tgctgctatg      600

gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat      660

acgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac      720

accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg      780

tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat      840

ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga atatctggaa      900

atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa      960

ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt     1020

cagcaactta ttacttataa agtcataagc aatgaattta acagtacaaa tctagtgaat     1080

gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta     1140

gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag     1200

tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct     1260

cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt     1320

atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat     1380

tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata     1440

ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt     1500

gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg     1560

agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc     1620

gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa     1680

ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc     1740

aatccagata ttggtatgtt cacatacgat aactctacaa aattgttttg gtttaatcca     1800

tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt     1860

tacaataaca ctatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg     1920

aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa     1980

gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca     2040

cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt     2100

ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat     2160

aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa     2220

tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg     2280

aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac     2340

tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga     2400

ctcttcttgc agaataatac gggcacagac agagcacctg tgggaggact aggaaaatta     2460

aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc     2520

tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg     2580

aaggccatca cgtatgccaa aggatttggc atgctgtaa                            2619


<210> 14
<211> 872
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg 
            20                  25                  30          


Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn 
        35                  40                  45              


Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Thr 
    50                  55                  60                  


Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys 
65                  70                  75                  80  


Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn 
                85                  90                  95      


Ser Thr Gly Ala Pro Asn Asn Thr Cys Ser Glu Ile Lys Met Asn Lys 
            100                 105                 110         


Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu 
        115                 120                 125             


Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser 
    130                 135                 140                 


Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu 
145                 150                 155                 160 


Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys 
                165                 170                 175     


Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys 
            180                 185                 190         


Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser 
        195                 200                 205             


Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Thr Gln Lys Leu 
    210                 215                 220                 


Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr 
225                 230                 235                 240 


Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala 
                245                 250                 255     


Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn 
            260                 265                 270         


Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met 
        275                 280                 285             


Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro 
    290                 295                 300                 


Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys 
305                 310                 315                 320 


Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met 
                325                 330                 335     


Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu 
            340                 345                 350         


Phe Asn Ser Thr Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala 
        355                 360                 365             


Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu 
    370                 375                 380                 


Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu 
385                 390                 395                 400 


Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn 
                405                 410                 415     


Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
            420                 425                 430         


Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn 
        435                 440                 445             


Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe 
    450                 455                 460                 


Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile 
465                 470                 475                 480 


Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile 
                485                 490                 495     


Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln 
            500                 505                 510         


Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His 
        515                 520                 525             


Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn 
    530                 535                 540                 


Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln 
545                 550                 555                 560 


Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val 
                565                 570                 575     


Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Asn Ser 
            580                 585                 590         


Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln 
        595                 600                 605             


Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Thr 
    610                 615                 620                 


Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly 
625                 630                 635                 640 


Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr 
                645                 650                 655     


Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp 
            660                 665                 670         


Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro 
        675                 680                 685             


Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn 
    690                 695                 700                 


Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn 
705                 710                 715                 720 


Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met 
                725                 730                 735     


Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile 
            740                 745                 750         


Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu 
        755                 760                 765             


Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile 
    770                 775                 780                 


Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg 
785                 790                 795                 800 


Leu Phe Leu Gln Asn Asn Thr Gly Thr Asp Arg Ala Pro Val Gly Gly 
                805                 810                 815     


Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu 
            820                 825                 830         


Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu 
        835                 840                 845             


Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr 
    850                 855                 860                 


Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870         


<210> 15
<211> 2688
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

atggagaagc tgcaccagtg ttattggaaa tcaggagaac ctcagtctga cgacattgaa      120

gctagccgaa tgaagcgagc agctgcaaag catctaatag aacgctacta ccaccagtta      180

actgagggct gtggaaatga agcctgcacg aatgagtttt gtgcttcctg tccaactttt      240

cttcgtatgg ataataatac agcagctatt aaagccctcg agctttataa gattaatgca      300

aaactctgtg atcctcatcc ctccaagaaa ggagcaagct cagcttacct tgagaactcg      360

acaggtgccc ccaacaacac ctgctctgag ataaaaatga acaagaaagg cgctagaatt      420

gattttaaag atgtgactta cttaacagaa gagaaggtat atgaaattct tgaattatgt      480

agagaaagag aggattattc ccctttaatc cgtgttattg gaagagtttt ttctagtgct      540

gaggcattgg tacagagctt ccggaaagtt aaacaacaca ccaaggaaga actgaaatct      600

cttcaagcaa aagatgaaga caaagatgaa gatgaaaagg aaaaagctgc atgttctgct      660

gctgctatgg aagaagactc agaagcatct tcctcaagga taggtgatag ctcacaggga      720

gacaacaata cgcaaaaatt aggccctgat gatgtgtctg tggatattga tgccattaga      780

agggtctaca ccagattgct ctctaatgaa aaaattgaaa ctgcctttct caatgcactt      840

gtatatttgt cacctaacgt ggaatgtgac ttgacgtatc acaatgtata ctctcgagat      900

cctaattatc tgaatttgtt cattatcgta atggagaata gaaatctcca cagtcctgaa      960

tatctggaaa tggctttgcc attattttgc aaagcgatga gcaagctacc ccttgcagcc     1020

caaggaaaac tgatcagact gtggtctaaa tacaatgcag accagattcg gagaatgatg     1080

gagacatttc agcaacttat tacttataaa gtcataagca atgaatttaa cagtacaaat     1140

ctagtgaatg atgatgatgc cattgttgct gcttcgaagt gcttgaaaat ggtttactat     1200

gcaaatgtag tgggagggga agtggacaca aatcacaatg aagaagatga tgaagagccc     1260

atccctgagt ccagcgagct gacacttcag gaacttttgg gagaagaaag aagaaacaag     1320

aaaggtcctc gagtggaccc cctggaaact gaacttggtg ttaaaaccct ggattgtcga     1380

aaaccactta tcccttttga agagtttatt aatgaaccac tgaatgaggt tctagaaatg     1440

gataaagatt atactttttt caaagtagaa acagagaaca aattctcttt tatgacatgt     1500

ccctttatat tgaatgctgt cacaaagaat ttgggattat attatgacaa tagaattcgc     1560

atgtacagtg aacgaagaat cactgttctc tacagcttag ttcaaggaca gcagttgaat     1620

ccatatttga gactcaaagt tagacgtgac catatcatag atgatgcact tgtccggcta     1680

gagatgatcg ctatggaaaa tcctgcagac ttgaagaagc agttgtatgt ggaatttgaa     1740

ggagaacaag gagttgatga gggaggtgtt tccaaagaat tttttcagct ggttgtggag     1800

gaaatcttca atccagatat tggtatgttc acatacgata actctacaaa attgttttgg     1860

tttaatccat cttcttttga aactgagggt cagtttactc tgattggcat agtactgggt     1920

ctggctattt acaataacac tatactggat gtacattttc ccatggttgt ctacaggaag     1980

ctaatgggga aaaaaggaac ttttcgtgac ttgggagact ctcacccagt tctatatcag     2040

agtttaaaag atttattgga gtatgaaggg aatgtggaag atgacatgat gatcactttc     2100

cagatatcac agacagatct ttttggtaac ccaatgatgt atgatctaaa ggaaaatggt     2160

gataaaattc caattacaaa tgaaaacagg aaggaatttg tcaatcttta ttctgactac     2220

attctcaata aatcagtaga aaaacagttc aaggcttttc ggagaggttt tcatatggtg     2280

accaatgaat ctcccttaaa gtacttattc agaccagaag aaattgaatt gcttatatgt     2340

ggaagccgga atctagattt ccaagcacta gaagaaacta cagaatatga cggtggctat     2400

accagggact ctgttctgat tagggagttc tgggaaatcg ttcattcatt tacagatgaa     2460

cagaaaagac tcttcttgca gaataatacg ggcacagaca gagcacctgt gggaggacta     2520

ggaaaattaa agatgattat agccaaaaat ggcccagaca cagaaaggtt acctacatct     2580

catacttgct ttaatgtgct tttacttccg gaatactcaa gcaaagaaaa acttaaagag     2640

agattgttga aggccatcac gtatgccaaa ggatttggca tgctgtaa                  2688


<210> 16
<211> 895
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly 
            20                  25                  30          


Glu Pro Gln Ser Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala 
        35                  40                  45              


Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys 
    50                  55                  60                  


Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe 
65                  70                  75                  80  


Leu Arg Met Asp Asn Asn Thr Ala Ala Ile Lys Ala Leu Glu Leu Tyr 
                85                  90                  95      


Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala 
            100                 105                 110         


Ser Ser Ala Tyr Leu Glu Asn Ser Thr Gly Ala Pro Asn Asn Thr Cys 
        115                 120                 125             


Ser Glu Ile Lys Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp 
    130                 135                 140                 


Val Thr Tyr Leu Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys 
145                 150                 155                 160 


Arg Glu Arg Glu Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val 
                165                 170                 175     


Phe Ser Ser Ala Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln 
            180                 185                 190         


His Thr Lys Glu Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys 
        195                 200                 205             


Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu 
    210                 215                 220                 


Glu Asp Ser Glu Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly 
225                 230                 235                 240 


Asp Asn Asn Thr Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile 
                245                 250                 255     


Asp Ala Ile Arg Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile 
            260                 265                 270         


Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu 
        275                 280                 285             


Cys Asp Leu Thr Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu 
    290                 295                 300                 


Asn Leu Phe Ile Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu 
305                 310                 315                 320 


Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu 
                325                 330                 335     


Pro Leu Ala Ala Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn 
            340                 345                 350         


Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr 
        355                 360                 365             


Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Thr Asn Leu Val Asn Asp 
    370                 375                 380                 


Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr 
385                 390                 395                 400 


Ala Asn Val Val Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp 
                405                 410                 415     


Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu 
            420                 425                 430         


Leu Gly Glu Glu Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu 
        435                 440                 445             


Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile 
    450                 455                 460                 


Pro Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met 
465                 470                 475                 480 


Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser 
                485                 490                 495     


Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly 
            500                 505                 510         


Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr 
        515                 520                 525             


Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg 
    530                 535                 540                 


Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu 
545                 550                 555                 560 


Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr 
                565                 570                 575     


Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys 
            580                 585                 590         


Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly 
        595                 600                 605             


Met Phe Thr Tyr Asp Asn Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser 
    610                 615                 620                 


Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly 
625                 630                 635                 640 


Leu Ala Ile Tyr Asn Asn Thr Ile Leu Asp Val His Phe Pro Met Val 
                645                 650                 655     


Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly 
            660                 665                 670         


Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr 
        675                 680                 685             


Glu Gly Asn Val Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln 
    690                 695                 700                 


Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly 
705                 710                 715                 720 


Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu 
                725                 730                 735     


Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala 
            740                 745                 750         


Phe Arg Arg Gly Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr 
        755                 760                 765             


Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn 
    770                 775                 780                 


Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr 
785                 790                 795                 800 


Thr Arg Asp Ser Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser 
                805                 810                 815     


Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln Asn Asn Thr Gly Thr 
            820                 825                 830         


Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala 
        835                 840                 845             


Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe 
    850                 855                 860                 


Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu 
865                 870                 875                 880 


Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
                885                 890                 895 


<210> 17
<211> 2679
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

atggccacag cttgtaaaag atcaggagaa cctcagtctg acgacattga agctagccga      120

atgaagcgag cagctgcaaa gcatctaata gaacgctact accaccagtt aactgagggc      180

tgtggaaatg aagcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      240

gataataata cagcagctat taaagccctc gagctttata agattaatgc aaaactctgt      300

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc gacaggtgcc      360

cccaacaaca cctgctctga gataaaaatg aacaagaaag gcgctagaat tgattttaaa      420

gatgtgactt acttaacaga agagaaggta tatgaaattc ttgaattatg tagagaaaga      480

gaggattatt cccctttaat ccgtgttatt ggaagagttt tttctagtgc tgaggcattg      540

gtacagagct tccggaaagt taaacaacac accaaggaag aactgaaatc tcttcaagca      600

aaagatgaag acaaagatga agatgaaaag gaaaaagctg catgttctgc tgctgctatg      660

gaagaagact cagaagcatc ttcctcaagg ataggtgata gctcacaggg agacaacaat      720

acgcaaaaat taggccctga tgatgtgtct gtggatattg atgccattag aagggtctac      780

accagattgc tctctaatga aaaaattgaa actgcctttc tcaatgcact tgtatatttg      840

tcacctaacg tggaatgtga cttgacgtat cacaatgtat actctcgaga tcctaattat      900

ctgaatttgt tcattatcgt aatggagaat agaaatctcc acagtcctga atatctggaa      960

atggctttgc cattattttg caaagcgatg agcaagctac cccttgcagc ccaaggaaaa     1020

ctgatcagac tgtggtctaa atacaatgca gaccagattc ggagaatgat ggagacattt     1080

cagcaactta ttacttataa agtcataagc aatgaattta acagtacaaa tctagtgaat     1140

gatgatgatg ccattgttgc tgcttcgaag tgcttgaaaa tggtttacta tgcaaatgta     1200

gtgggagggg aagtggacac aaatcacaat gaagaagatg atgaagagcc catccctgag     1260

tccagcgagc tgacacttca ggaacttttg ggagaagaaa gaagaaacaa gaaaggtcct     1320

cgagtggacc ccctggaaac tgaacttggt gttaaaaccc tggattgtcg aaaaccactt     1380

atcccttttg aagagtttat taatgaacca ctgaatgagg ttctagaaat ggataaagat     1440

tatacttttt tcaaagtaga aacagagaac aaattctctt ttatgacatg tccctttata     1500

ttgaatgctg tcacaaagaa tttgggatta tattatgaca atagaattcg catgtacagt     1560

gaacgaagaa tcactgttct ctacagctta gttcaaggac agcagttgaa tccatatttg     1620

agactcaaag ttagacgtga ccatatcata gatgatgcac ttgtccggct agagatgatc     1680

gctatggaaa atcctgcaga cttgaagaag cagttgtatg tggaatttga aggagaacaa     1740

ggagttgatg agggaggtgt ttccaaagaa ttttttcagc tggttgtgga ggaaatcttc     1800

aatccagata ttggtatgtt cacatacgat aactctacaa aattgttttg gtttaatcca     1860

tcttcttttg aaactgaggg tcagtttact ctgattggca tagtactggg tctggctatt     1920

tacaataaca ctatactgga tgtacatttt cccatggttg tctacaggaa gctaatgggg     1980

aaaaaaggaa cttttcgtga cttgggagac tctcacccag ttctatatca gagtttaaaa     2040

gatttattgg agtatgaagg gaatgtggaa gatgacatga tgatcacttt ccagatatca     2100

cagacagatc tttttggtaa cccaatgatg tatgatctaa aggaaaatgg tgataaaatt     2160

ccaattacaa atgaaaacag gaaggaattt gtcaatcttt attctgacta cattctcaat     2220

aaatcagtag aaaaacagtt caaggctttt cggagaggtt ttcatatggt gaccaatgaa     2280

tctcccttaa agtacttatt cagaccagaa gaaattgaat tgcttatatg tggaagccgg     2340

aatctagatt tccaagcact agaagaaact acagaatatg acggtggcta taccagggac     2400

tctgttctga ttagggagtt ctgggaaatc gttcattcat ttacagatga acagaaaaga     2460

ctcttcttgc agaataatac gggcacagac agagcacctg tgggaggact aggaaaatta     2520

aagatgatta tagccaaaaa tggcccagac acagaaaggt tacctacatc tcatacttgc     2580

tttaatgtgc ttttacttcc ggaatactca agcaaagaaa aacttaaaga gagattgttg     2640

aaggccatca cgtatgccaa aggatttggc atgctgtaa                            2679


<210> 18
<211> 892
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Met Ala Thr Ala Cys Lys Arg Ser Gly Glu Pro Gln 
            20                  25                  30          


Ser Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His 
        35                  40                  45              


Leu Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu 
    50                  55                  60                  


Ala Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met 
65                  70                  75                  80  


Asp Asn Asn Thr Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn 
                85                  90                  95      


Ala Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala 
            100                 105                 110         


Tyr Leu Glu Asn Ser Thr Gly Ala Pro Asn Asn Thr Cys Ser Glu Ile 
        115                 120                 125             


Lys Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr 
    130                 135                 140                 


Leu Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg 
145                 150                 155                 160 


Glu Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser 
                165                 170                 175     


Ala Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys 
            180                 185                 190         


Glu Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp 
        195                 200                 205             


Glu Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser 
    210                 215                 220                 


Glu Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn 
225                 230                 235                 240 


Thr Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile 
                245                 250                 255     


Arg Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala 
            260                 265                 270         


Phe Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu 
        275                 280                 285             


Thr Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe 
    290                 295                 300                 


Ile Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu 
305                 310                 315                 320 


Met Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala 
                325                 330                 335     


Ala Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln 
            340                 345                 350         


Ile Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val 
        355                 360                 365             


Ile Ser Asn Glu Phe Asn Ser Thr Asn Leu Val Asn Asp Asp Asp Ala 
    370                 375                 380                 


Ile Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val 
385                 390                 395                 400 


Val Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu 
                405                 410                 415     


Pro Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu 
            420                 425                 430         


Glu Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu 
        435                 440                 445             


Leu Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu 
    450                 455                 460                 


Glu Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp 
465                 470                 475                 480 


Tyr Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr 
                485                 490                 495     


Cys Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr 
            500                 505                 510         


Asp Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr 
        515                 520                 525             


Ser Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val 
    530                 535                 540                 


Arg Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile 
545                 550                 555                 560 


Ala Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe 
                565                 570                 575     


Glu Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe 
            580                 585                 590         


Gln Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr 
        595                 600                 605             


Tyr Asp Asn Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu 
    610                 615                 620                 


Thr Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile 
625                 630                 635                 640 


Tyr Asn Asn Thr Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg 
                645                 650                 655     


Lys Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His 
            660                 665                 670         


Pro Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn 
        675                 680                 685             


Val Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu 
    690                 695                 700                 


Phe Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile 
705                 710                 715                 720 


Pro Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp 
                725                 730                 735     


Tyr Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg 
            740                 745                 750         


Gly Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg 
        755                 760                 765             


Pro Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe 
    770                 775                 780                 


Gln Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp 
785                 790                 795                 800 


Ser Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp 
                805                 810                 815     


Glu Gln Lys Arg Leu Phe Leu Gln Asn Asn Thr Gly Thr Asp Arg Ala 
            820                 825                 830         


Pro Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly 
        835                 840                 845             


Pro Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu 
    850                 855                 860                 


Leu Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu 
865                 870                 875                 880 


Lys Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
                885                 890         


<210> 19
<211> 2613
<212> DNA
<213> Mus sp.

<400> 19
atggccacag cttgtaaaag atcaccagga gaatcccagt ctgaggacat tgaagctagc       60

cgaatgaagc gagcagctgc aaagcatcta atagaacgct actaccatca gttaactgag      120

ggctgtggaa atgaggcctg cacgaatgag ttttgtgctt cctgtccaac ttttcttcgt      180

atggataaca atgcagcagc tattaaagcc cttgagcttt ataaaattaa tgcaaaactc      240

tgtgatcctc atccctccaa gaaaggagca agctcagctt accttgagaa ctcaaaaggt      300

gcatctaaca actcagagat aaaaatgaac aagaaggaag gaaaagattt taaagatgtg      360

atttacctaa ctgaagagaa agtatatgaa atttatgaat tttgtagaga gagtgaggat      420

tattcccctt taattcgtgt aattggaaga atattttcta gtgctgaggc actggttctg      480

agctttcgga aagtcaaaca gcacacaaag gaggaattga aatctcttca agaaaaggat      540

gaagacaagg atgaagatga aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa      600

gactcagaag catcttcttc aaggatgggt gatagttcac agggagacaa caatgtacaa      660

aaattaggtc ctgatgatgt gactgtggat attgatgcta ttagaagggt ctacagcagt      720

ttgctcgcta atgaaaaatt agaaactgcc ttcctgaatg cacttgtata tctgtcacct      780

aacgtggaat gtgatttgac atatcataat gtgtatactc gagatcctaa ttatctcaat      840

ttgttcatta ttgtaatgga gaatagtaat ctccacagtc ctgaatatct ggaaatggcg      900

ttgccattat tttgcaaagc tatgtgtaag ctaccccttg aagctcaagg aaaactgatt      960

aggctgtggt ctaaatacag tgctgaccag attcggagaa tgatggaaac atttcagcaa     1020

cttattacct acaaagtcat aagcaatgaa tttaatagcc gaaatctagt gaatgatgat     1080

gatgccattg ttgctgcttc aaagtgtttg aaaatggttt actatgcaaa tgtagtggga     1140

ggggatgtgg acacaaatca taatgaggaa gatgatgaag aacccatacc tgagtccagc     1200

gaattaacac ttcaggagct tctgggagat gaaagaagaa ataagaaagg tcctcgagtg     1260

gatccactag aaaccgaact tggcgttaaa actctagact gtcgaaaacc acttatctcc     1320

tttgaagaat tcattaatga accactgaat gatgttctag aaatggacaa agattatacc     1380

tttttcaaag ttgaaacaga gaacaaattc tcttttatga catgtccctt tatattgaat     1440

gctgtcacaa agaatctggg attatattat gacaatagaa ttcgcatgta cagtgaaaga     1500

agaatcactg ttctttacag cctagttcaa ggacagcagt tgaatccgta tttgagactc     1560

aaagtcagac gtgaccatat tatagatgat gcactggtcc ggctagagat gattgctatg     1620

gaaaatcctg cagacttgaa gaagcagttg tatgtggaat ttgaaggaga acaaggagta     1680

gatgagggag gcgtttccaa agagtttttt cagttggttg tggaggaaat ttttaatcca     1740

gatattggta tgttcacata tgatgaagct acgaaattat tttggtttaa tccatcttct     1800

tttgaaactg agggtcagtt tactctgatt ggcatagtcc tgggtctggc tatttacaat     1860

aattgtatac tggatgtcca ttttcccatg gttgtataca ggaagctaat ggggaaaaaa     1920

ggaacctttc gtgacttggg agactctcac ccagttttat atcagagttt aaaggattta     1980

ttggaatatg aagggagtgt ggaagatgat atgatgatca ctttccagat atcacagaca     2040

gatctttttg gtaacccaat gatgtatgat ctaaaagaaa atggtgataa aattccaatt     2100

acaaatgaaa acaggaagga atttgtcaat ctctattcag actacattct caataaatct     2160

gtagaaaaac aattcaaggc atttcgcaga ggttttcata tggtgactaa tgaatcgccc     2220

ttaaaatact tattcagacc agaagaaatt gaattgctta tatgtggaag ccggaatcta     2280

gatttccagg cactagaaga aactacagag tatgacggtg gctatacgag ggaatctgtt     2340

gtgattaggg agttctggga aattgttcat tcgtttacag atgaacagaa aagactcttt     2400

ctgcagttta caacaggcac agacagagca cctgttggag gactaggaaa attgaagatg     2460

attatagcca aaaatggccc agacacagaa aggttaccta catctcatac ttgctttaat     2520

gtccttttac ttccggaata ttcaagcaaa gaaaaactta aagagagatt gttgaaggcc     2580

atcacatatg ccaaaggatt tggcatgctg taa                                  2613


<210> 20
<211> 870
<212> PRT
<213> Mus sp.

<400> 20
Met Ala Thr Ala Cys Lys Arg Ser Pro Gly Glu Ser Gln Ser Glu Asp 
1               5                   10                  15      


Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu 
            20                  25                  30          


Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr 
        35                  40                  45              


Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn 
    50                  55                  60                  


Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu 
65                  70                  75                  80  


Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu 
                85                  90                  95      


Asn Ser Lys Gly Ala Ser Asn Asn Ser Glu Ile Lys Met Asn Lys Lys 
            100                 105                 110         


Glu Gly Lys Asp Phe Lys Asp Val Ile Tyr Leu Thr Glu Glu Lys Val 
        115                 120                 125             


Tyr Glu Ile Tyr Glu Phe Cys Arg Glu Ser Glu Asp Tyr Ser Pro Leu 
    130                 135                 140                 


Ile Arg Val Ile Gly Arg Ile Phe Ser Ser Ala Glu Ala Leu Val Leu 
145                 150                 155                 160 


Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu 
                165                 170                 175     


Gln Glu Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala 
            180                 185                 190         


Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg 
        195                 200                 205             


Met Gly Asp Ser Ser Gln Gly Asp Asn Asn Val Gln Lys Leu Gly Pro 
    210                 215                 220                 


Asp Asp Val Thr Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Ser Ser 
225                 230                 235                 240 


Leu Leu Ala Asn Glu Lys Leu Glu Thr Ala Phe Leu Asn Ala Leu Val 
                245                 250                 255     


Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr 
            260                 265                 270         


Thr Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn 
        275                 280                 285             


Ser Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe 
    290                 295                 300                 


Cys Lys Ala Met Cys Lys Leu Pro Leu Glu Ala Gln Gly Lys Leu Ile 
305                 310                 315                 320 


Arg Leu Trp Ser Lys Tyr Ser Ala Asp Gln Ile Arg Arg Met Met Glu 
                325                 330                 335     


Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn 
            340                 345                 350         


Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys 
        355                 360                 365             


Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Asp Val Asp 
    370                 375                 380                 


Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser 
385                 390                 395                 400 


Glu Leu Thr Leu Gln Glu Leu Leu Gly Asp Glu Arg Arg Asn Lys Lys 
                405                 410                 415     


Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu 
            420                 425                 430         


Asp Cys Arg Lys Pro Leu Ile Ser Phe Glu Glu Phe Ile Asn Glu Pro 
        435                 440                 445             


Leu Asn Asp Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val 
    450                 455                 460                 


Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn 
465                 470                 475                 480 


Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met 
                485                 490                 495     


Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln 
            500                 505                 510         


Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile 
        515                 520                 525             


Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala 
    530                 535                 540                 


Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val 
545                 550                 555                 560 


Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu 
                565                 570                 575     


Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ala Thr Lys 
            580                 585                 590         


Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr 
        595                 600                 605             


Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu 
    610                 615                 620                 


Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys 
625                 630                 635                 640 


Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser 
                645                 650                 655     


Leu Lys Asp Leu Leu Glu Tyr Glu Gly Ser Val Glu Asp Asp Met Met 
            660                 665                 670         


Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met 
        675                 680                 685             


Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn 
    690                 695                 700                 


Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser 
705                 710                 715                 720 


Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr 
                725                 730                 735     


Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu 
            740                 745                 750         


Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr 
        755                 760                 765             


Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Glu Ser Val Val Ile Arg Glu 
    770                 775                 780                 


Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe 
785                 790                 795                 800 


Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly 
                805                 810                 815     


Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu 
            820                 825                 830         


Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser 
        835                 840                 845             


Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala 
    850                 855                 860                 


Lys Gly Phe Gly Met Leu 
865                 870 


<210> 21
<211> 2613
<212> DNA
<213> Mus sp.

<400> 21
atggccacag cttgtaaaag atcaccagga gaatcccagt ctgaggacat tgaagctagc       60

cgaatgaagc gagcagctgc aaagcatcta atagaacgct actaccatca gttaactgag      120

ggctgtggaa atgaggcctg cacgaatgag ttttgtgctt cctgtccaac ttttcttcgt      180

atggataaca atgcagcagc tattaaagcc cttgagcttt ataaaattaa tgcaaaactc      240

tgtgatcctc atccctccaa gaaaggagca agctcagctt accttgagaa ctcaaaaggt      300

gcatctaaca actcagagat aaaaatgaac aagaaggaag gaaaagattt taaagatgtg      360

atttacctaa ctgaagagaa agtatatgaa atttatgaat tttgtagaga gagtgaggat      420

tattcccctt taattcgtgt aattggaaga atattttcta gtgctgaggc actggttctg      480

agctttcgga aagtcaaaca gcacacaaag gaggaattga aatctcttca agaaaaggat      540

gaagacaagg atgaagatga aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa      600

gactcagaag catcttcttc aaggatgggt gatagttcac agggagacaa caatgtacaa      660

aaattaggtc ctgatgatgt gactgtggat attgatgcta ttagaagggt ctacagcagt      720

ttgctcgcta atgaaaaatt agaaactgcc ttcctgaatg cacttgtata tctgtcacct      780

aacgtggaat gtgatttgac atatcataat gtgtatactc gagatcctaa ttatctcaat      840

ttgttcatta ttgtaatgga gaatagtaat ctccacagtc ctgaatatct ggaaatggcg      900

ttgccattat tttgcaaagc tatgtgtaag ctaccccttg aagctcaagg aaaactgatt      960

aggctgtggt ctaaatacag tgctgaccag attcggagaa tgatggaaac atttcagcaa     1020

cttattacct acaaagtcat aagcaatgaa tttaatagcc gaaatctagt gaatgatgat     1080

gatgccattg ttgctgcttc aaagtgtttg aaaatggttt actatgcaaa tgtagtggga     1140

ggggatgtgg acacaaatca taatgaggaa gatgatgaag aacccatacc tgagtccagc     1200

gaattaacac ttcaggagct tctgggagat gaaagaagaa ataagaaagg tcctcgagtg     1260

gatccactag aaaccgaact tggcgttaaa actctagact gtcgaaaacc acttatctcc     1320

tttgaagaat tcattaatga accactgaat gatgttctag aaatggacaa agattatacc     1380

tttttcaaag ttgaaacaga gaacaaattc tcttttatga catgtccctt tatattgaat     1440

gctgtcacaa agaatctggg attatattat gacaatagaa ttcgcatgta cagtgaaaga     1500

agaatcactg ttctttacag cctagttcaa ggacagcagt tgaatccgta tttgagactc     1560

aaagtcagac gtgaccatat tatagatgat gcactggtcc ggctagagat gattgctatg     1620

gaaaatcctg cagacttgaa gaagcagttg tatgtggaat ttgaaggaga acaaggagta     1680

gatgagggag gcgtttccaa agagtttttt cagttggttg tggaggaaat ttttaatcca     1740

gatattggta tgttcacata tgatgaagct acgaaattat tttggtttaa tccatcttct     1800

tttgaaactg agggtcagtt tactctgatt ggcatagtcc tgggtctggc tatttacaat     1860

aattgtatac tggatgtcca ttttcccatg gttgtataca ggaagctaat ggggaaaaaa     1920

ggaacctttc gtgacttggg agactctcac ccagttttat atcagagttt aaaggattta     1980

ttggaatatg aagggagtgt ggaagatgat atgatgatca ctttccagat atcacagaca     2040

gatctttttg gtaacccaat gatgtatgat ctaaaagaaa atggtgataa aattccaatt     2100

acaaatgaaa acaggaagga atttgtcaat ctctattcag actacattct caataaatct     2160

gtagaaaaac aattcaaggc atttcgcaga ggttttcata tggtgactaa tgaatcgccc     2220

ttaaaatact tattcagacc agaagaaatt gaattgctta tatgtggaag ccggaatcta     2280

gatttccagg cactagaaga aactacagag tatgacggtg gctatacgag ggaatctgtt     2340

gtgattaggg agttctggga aattgttcat tcgtttacag atgaacagaa aagactcttt     2400

ctgcagttta caacaggcac agacagagca cctgttggag gactaggaaa attgaagatg     2460

attatagcca aaaatggccc agacacagaa aggttaccta catctcatac ttgctttaat     2520

gtccttttac ttccggaata ttcaagcaaa gaaaaactta aagagagatt gttgaaggcc     2580

atcacatatg ccaaaggatt tggcatgctg taa                                  2613


<210> 22
<211> 870
<212> PRT
<213> Mus sp.

<400> 22
Met Ala Thr Ala Cys Lys Arg Ser Pro Gly Glu Ser Gln Ser Glu Asp 
1               5                   10                  15      


Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu 
            20                  25                  30          


Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr 
        35                  40                  45              


Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn 
    50                  55                  60                  


Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu 
65                  70                  75                  80  


Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu 
                85                  90                  95      


Asn Ser Lys Gly Ala Ser Asn Asn Ser Glu Ile Lys Met Asn Lys Lys 
            100                 105                 110         


Glu Gly Lys Asp Phe Lys Asp Val Ile Tyr Leu Thr Glu Glu Lys Val 
        115                 120                 125             


Tyr Glu Ile Tyr Glu Phe Cys Arg Glu Ser Glu Asp Tyr Ser Pro Leu 
    130                 135                 140                 


Ile Arg Val Ile Gly Arg Ile Phe Ser Ser Ala Glu Ala Leu Val Leu 
145                 150                 155                 160 


Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu 
                165                 170                 175     


Gln Glu Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala 
            180                 185                 190         


Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg 
        195                 200                 205             


Met Gly Asp Ser Ser Gln Gly Asp Asn Asn Val Gln Lys Leu Gly Pro 
    210                 215                 220                 


Asp Asp Val Thr Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Ser Ser 
225                 230                 235                 240 


Leu Leu Ala Asn Glu Lys Leu Glu Thr Ala Phe Leu Asn Ala Leu Val 
                245                 250                 255     


Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr 
            260                 265                 270         


Thr Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn 
        275                 280                 285             


Ser Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe 
    290                 295                 300                 


Cys Lys Ala Met Cys Lys Leu Pro Leu Glu Ala Gln Gly Lys Leu Ile 
305                 310                 315                 320 


Arg Leu Trp Ser Lys Tyr Ser Ala Asp Gln Ile Arg Arg Met Met Glu 
                325                 330                 335     


Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn 
            340                 345                 350         


Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys 
        355                 360                 365             


Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Asp Val Asp 
    370                 375                 380                 


Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser 
385                 390                 395                 400 


Glu Leu Thr Leu Gln Glu Leu Leu Gly Asp Glu Arg Arg Asn Lys Lys 
                405                 410                 415     


Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu 
            420                 425                 430         


Asp Cys Arg Lys Pro Leu Ile Ser Phe Glu Glu Phe Ile Asn Glu Pro 
        435                 440                 445             


Leu Asn Asp Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val 
    450                 455                 460                 


Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn 
465                 470                 475                 480 


Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met 
                485                 490                 495     


Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln 
            500                 505                 510         


Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile 
        515                 520                 525             


Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala 
    530                 535                 540                 


Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val 
545                 550                 555                 560 


Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu 
                565                 570                 575     


Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ala Thr Lys 
            580                 585                 590         


Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr 
        595                 600                 605             


Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu 
    610                 615                 620                 


Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys 
625                 630                 635                 640 


Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser 
                645                 650                 655     


Leu Lys Asp Leu Leu Glu Tyr Glu Gly Ser Val Glu Asp Asp Met Met 
            660                 665                 670         


Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met 
        675                 680                 685             


Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn 
    690                 695                 700                 


Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser 
705                 710                 715                 720 


Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr 
                725                 730                 735     


Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu 
            740                 745                 750         


Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr 
        755                 760                 765             


Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Glu Ser Val Val Ile Arg Glu 
    770                 775                 780                 


Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe 
785                 790                 795                 800 


Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly 
                805                 810                 815     


Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu 
            820                 825                 830         


Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser 
        835                 840                 845             


Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala 
    850                 855                 860                 


Lys Gly Phe Gly Met Leu 
865                 870 


<210> 23
<211> 2550
<212> DNA
<213> Mus sp.

<400> 23
atgaagcgag cagctgcaaa gcatctaata gaacgctact accatcagtt aactgagggc       60

tgtggaaatg aggcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      120

gataacaatg cagcagctat taaagccctt gagctttata aaattaatgc aaaactctgt      180

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc aaaaggtgca      240

tctaacaact cagagataaa aatgaacaag aaggaaggaa aagattttaa agatgtgatt      300

tacctaactg aagagaaagt atatgaaatt tatgaatttt gtagagagag tgaggattat      360

tcccctttaa ttcgtgtaat tggaagaata ttttctagtg ctgaggcact ggttctgagc      420

tttcggaaag tcaaacagca cacaaaggag gaattgaaat ctcttcaaga aaaggatgaa      480

gacaaggatg aagatgaaaa ggaaaaagct gcatgttctg ctgctgctat ggaagaagac      540

tcagaagcat cttcttcaag gatgggtgat agttcacagg gagacaacaa tgtacaaaaa      600

ttaggtcctg atgatgtgac tgtggatatt gatgctatta gaagggtcta cagcagtttg      660

ctcgctaatg aaaaattaga aactgccttc ctgaatgcac ttgtatatct gtcacctaac      720

gtggaatgtg atttgacata tcataatgtg tatactcgag atcctaatta tctcaatttg      780

ttcattattg taatggagaa tagtaatctc cacagtcctg aatatctgga aatggcgttg      840

ccattatttt gcaaagctat gtgtaagcta ccccttgaag ctcaaggaaa actgattagg      900

ctgtggtcta aatacagtgc tgaccagatt cggagaatga tggaaacatt tcagcaactt      960

attacctaca aagtcataag caatgaattt aatagccgaa atctagtgaa tgatgatgat     1020

gccattgttg ctgcttcaaa gtgtttgaaa atggtttact atgcaaatgt agtgggaggg     1080

gatgtggaca caaatcataa tgaggaagat gatgaagaac ccatacctga gtccagcgaa     1140

ttaacacttc aggagcttct gggagatgaa agaagaaata agaaaggtcc tcgagtggat     1200

ccactagaaa ccgaacttgg cgttaaaact ctagactgtc gaaaaccact tatctccttt     1260

gaagaattca ttaatgaacc actgaatgat gttctagaaa tggacaaaga ttataccttt     1320

ttcaaagttg aaacagagaa caaattctct tttatgacat gtccctttat attgaatgct     1380

gtcacaaaga atctgggatt atattatgac aatagaattc gcatgtacag tgaaagaaga     1440

atcactgttc tttacagcct agttcaagga cagcagttga atccgtattt gagactcaaa     1500

gtcagacgtg accatattat agatgatgca ctggtccggc tagagatgat tgctatggaa     1560

aatcctgcag acttgaagaa gcagttgtat gtggaatttg aaggagaaca aggagtagat     1620

gagggaggcg tttccaaaga gttttttcag ttggttgtgg aggaaatttt taatccagat     1680

attggtatgt tcacatatga tgaagctacg aaattatttt ggtttaatcc atcttctttt     1740

gaaactgagg gtcagtttac tctgattggc atagtcctgg gtctggctat ttacaataat     1800

tgtatactgg atgtccattt tcccatggtt gtatacagga agctaatggg gaaaaaagga     1860

acctttcgtg acttgggaga ctctcaccca gttttatatc agagtttaaa ggatttattg     1920

gaatatgaag ggagtgtgga agatgatatg atgatcactt tccagatatc acagacagat     1980

ctttttggta acccaatgat gtatgatcta aaagaaaatg gtgataaaat tccaattaca     2040

aatgaaaaca ggaaggaatt tgtcaatctc tattcagact acattctcaa taaatctgta     2100

gaaaaacaat tcaaggcatt tcgcagaggt tttcatatgg tgactaatga atcgccctta     2160

aaatacttat tcagaccaga agaaattgaa ttgcttatat gtggaagccg gaatctagat     2220

ttccaggcac tagaagaaac tacagagtat gacggtggct atacgaggga atctgttgtg     2280

attagggagt tctgggaaat tgttcattcg tttacagatg aacagaaaag actctttctg     2340

cagtttacaa caggcacaga cagagcacct gttggaggac taggaaaatt gaagatgatt     2400

atagccaaaa atggcccaga cacagaaagg ttacctacat ctcatacttg ctttaatgtc     2460

cttttacttc cggaatattc aagcaaagaa aaacttaaag agagattgtt gaaggccatc     2520

acatatgcca aaggatttgg catgctgtaa                                      2550


<210> 24
<211> 849
<212> PRT
<213> Mus sp.

<400> 24
Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr His Gln 
1               5                   10                  15      


Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe Cys Ala 
            20                  25                  30          


Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala Ile Lys 
        35                  40                  45              


Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro His Pro 
    50                  55                  60                  


Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys Gly Ala 
65                  70                  75                  80  


Ser Asn Asn Ser Glu Ile Lys Met Asn Lys Lys Glu Gly Lys Asp Phe 
                85                  90                  95      


Lys Asp Val Ile Tyr Leu Thr Glu Glu Lys Val Tyr Glu Ile Tyr Glu 
            100                 105                 110         


Phe Cys Arg Glu Ser Glu Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly 
        115                 120                 125             


Arg Ile Phe Ser Ser Ala Glu Ala Leu Val Leu Ser Phe Arg Lys Val 
    130                 135                 140                 


Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln Glu Lys Asp Glu 
145                 150                 155                 160 


Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala 
                165                 170                 175     


Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Met Gly Asp Ser Ser 
            180                 185                 190         


Gln Gly Asp Asn Asn Val Gln Lys Leu Gly Pro Asp Asp Val Thr Val 
        195                 200                 205             


Asp Ile Asp Ala Ile Arg Arg Val Tyr Ser Ser Leu Leu Ala Asn Glu 
    210                 215                 220                 


Lys Leu Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn 
225                 230                 235                 240 


Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Thr Arg Asp Pro Asn 
                245                 250                 255     


Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Ser Asn Leu His Ser 
            260                 265                 270         


Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys Lys Ala Met Cys 
        275                 280                 285             


Lys Leu Pro Leu Glu Ala Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys 
    290                 295                 300                 


Tyr Ser Ala Asp Gln Ile Arg Arg Met Met Glu Thr Phe Gln Gln Leu 
305                 310                 315                 320 


Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser Arg Asn Leu Val 
                325                 330                 335     


Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys Leu Lys Met Val 
            340                 345                 350         


Tyr Tyr Ala Asn Val Val Gly Gly Asp Val Asp Thr Asn His Asn Glu 
        355                 360                 365             


Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln 
    370                 375                 380                 


Glu Leu Leu Gly Asp Glu Arg Arg Asn Lys Lys Gly Pro Arg Val Asp 
385                 390                 395                 400 


Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp Cys Arg Lys Pro 
                405                 410                 415     


Leu Ile Ser Phe Glu Glu Phe Ile Asn Glu Pro Leu Asn Asp Val Leu 
            420                 425                 430         


Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu Thr Glu Asn Lys 
        435                 440                 445             


Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala Val Thr Lys Asn 
    450                 455                 460                 


Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg 
465                 470                 475                 480 


Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr 
                485                 490                 495     


Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp Asp Ala Leu Val 
            500                 505                 510         


Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp Leu Lys Lys Gln 
        515                 520                 525             


Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp Glu Gly Gly Val 
    530                 535                 540                 


Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile Phe Asn Pro Asp 
545                 550                 555                 560 


Ile Gly Met Phe Thr Tyr Asp Glu Ala Thr Lys Leu Phe Trp Phe Asn 
                565                 570                 575     


Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu Ile Gly Ile Val 
            580                 585                 590         


Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu Asp Val His Phe Pro 
        595                 600                 605             


Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly Thr Phe Arg Asp 
    610                 615                 620                 


Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu 
625                 630                 635                 640 


Glu Tyr Glu Gly Ser Val Glu Asp Asp Met Met Ile Thr Phe Gln Ile 
                645                 650                 655     


Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr Asp Leu Lys Glu 
            660                 665                 670         


Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg Lys Glu Phe Val 
        675                 680                 685             


Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val Glu Lys Gln Phe 
    690                 695                 700                 


Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn Glu Ser Pro Leu 
705                 710                 715                 720 


Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser 
                725                 730                 735     


Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly 
            740                 745                 750         


Gly Tyr Thr Arg Glu Ser Val Val Ile Arg Glu Phe Trp Glu Ile Val 
        755                 760                 765             


His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr 
    770                 775                 780                 


Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys Leu Lys Met Ile 
785                 790                 795                 800 


Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro Thr Ser His Thr 
                805                 810                 815     


Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu 
            820                 825                 830         


Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met 
        835                 840                 845             


Leu 
    


<210> 25
<211> 2673
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

atggccacag cttgtaaaag atcaccagga gaatcccagt ctgaggacat tgaagctagc      120

cgaatgaagc gagcagctgc aaagcatcta atagaacgct actaccatca gttaactgag      180

ggctgtggaa atgaggcctg cacgaatgag ttttgtgctt cctgtccaac ttttcttcgt      240

atggataaca atacagcagc tattaaagcc cttgagcttt ataaaattaa tgcaaaactc      300

tgtgatcctc atccctccaa gaaaggagca agctcagctt accttgagaa ctcaacaggt      360

gcatctaaca acacagagat aaaaatgaac aagaaggaag gaaaagattt taaagatgtg      420

atttacctaa ctgaagagaa agtatatgaa atttatgaat tttgtagaga gagtgaggat      480

tattcccctt taattcgtgt aattggaaga atattttcta gtgctgaggc actggttctg      540

agctttcgga aagtcaaaca gcacacaaag gaggaattga aatctcttca agaaaaggat      600

gaagacaagg atgaagatga aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa      660

gactcagaag catcttcttc aaggatgggt gatagttcac agggagacaa caatacacaa      720

aaattaggtc ctgatgatgt gactgtggat attgatgcta ttagaagggt ctacagcagt      780

ttgctcgcta atgaaaaatt agaaactgcc ttcctgaatg cacttgtata tctgtcacct      840

aacgtggaat gtgatttgac atatcataat gtgtatactc gagatcctaa ttatctcaat      900

ttgttcatta ttgtaatgga gaatagtaat ctccacagtc ctgaatatct ggaaatggcg      960

ttgccattat tttgcaaagc tatgtgtaag ctaccccttg aagctcaagg aaaactgatt     1020

aggctgtggt ctaaatacag tgctgaccag attcggagaa tgatggaaac atttcagcaa     1080

cttattacct acaaagtcat aagcaatgaa tttaatagca caaatctagt gaatgatgat     1140

gatgccattg ttgctgcttc aaagtgtttg aaaatggttt actatgcaaa tgtagtggga     1200

ggggatgtgg acacaaatca taatgaggaa gatgatgaag aacccatacc tgagtccagc     1260

gaattaacac ttcaggagct tctgggagat gaaagaagaa ataagaaagg tcctcgagtg     1320

gatccactag aaaccgaact tggcgttaaa actctagact gtcgaaaacc acttatctcc     1380

tttgaagaat tcattaatga accactgaat gatgttctag aaatggacaa agattatacc     1440

tttttcaaag ttgaaacaga gaacaaattc tcttttatga catgtccctt tatattgaat     1500

gctgtcacaa agaatctggg attatattat gacaatagaa ttcgcatgta cagtgaaaga     1560

agaatcactg ttctttacag cctagttcaa ggacagcagt tgaatccgta tttgagactc     1620

aaagtcagac gtgaccatat tatagatgat gcactggtcc ggctagagat gattgctatg     1680

gaaaatcctg cagacttgaa gaagcagttg tatgtggaat ttgaaggaga acaaggagta     1740

gatgagggag gcgtttccaa agagtttttt cagttggttg tggaggaaat ttttaatcca     1800

gatattggta tgttcacata tgataataat acgaaattat tttggtttaa tccatcttct     1860

tttgaaactg agggtcagtt tactctgatt ggcatagtcc tgggtctggc tatttacaat     1920

aatactatac tggatgtcca ttttcccatg gttgtataca ggaagctaat ggggaaaaaa     1980

ggaacctttc gtgacttggg agactctcac ccagttttat atcagagttt aaaggattta     2040

ttggaatatg aagggagtgt ggaagatgat atgatgatca ctttccagat atcacagaca     2100

gatctttttg gtaacccaat gatgtatgat ctaaaagaaa atggtgataa aattccaatt     2160

acaaatgaaa acaggaagga atttgtcaat ctctattcag actacattct caataaatct     2220

gtagaaaaac aattcaaggc atttcgcaga ggttttcata tggtgactaa tgaatcgccc     2280

ttaaaatact tattcagacc agaagaaatt gaattgctta tatgtggaag ccggaatcta     2340

gatttccagg cactagaaga aactacagag tatgacggtg gctatacgag ggaatctgtt     2400

gtgattaggg agttctggga aattgttcat tcgtttacag atgaacagaa aagactcttt     2460

ctgcagaata caacaggcac agacagagca cctgttggag gactaggaaa attgaagatg     2520

attatagcca aaaatggccc agacacagaa aggttaccta catctcatac ttgctttaat     2580

gtccttttac ttccggaata ttcaagcaaa gaaaaactta aagagagatt gttgaaggcc     2640

atcacatatg ccaaaggatt tggcatgctg taa                                  2673


<210> 26
<211> 890
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Met Ala Thr Ala Cys Lys Arg Ser Pro Gly Glu Ser 
            20                  25                  30          


Gln Ser Glu Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys 
        35                  40                  45              


His Leu Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn 
    50                  55                  60                  


Glu Ala Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg 
65                  70                  75                  80  


Met Asp Asn Asn Thr Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile 
                85                  90                  95      


Asn Ala Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser 
            100                 105                 110         


Ala Tyr Leu Glu Asn Ser Thr Gly Ala Ser Asn Asn Thr Glu Ile Lys 
        115                 120                 125             


Met Asn Lys Lys Glu Gly Lys Asp Phe Lys Asp Val Ile Tyr Leu Thr 
    130                 135                 140                 


Glu Glu Lys Val Tyr Glu Ile Tyr Glu Phe Cys Arg Glu Ser Glu Asp 
145                 150                 155                 160 


Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Ile Phe Ser Ser Ala Glu 
                165                 170                 175     


Ala Leu Val Leu Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu 
            180                 185                 190         


Leu Lys Ser Leu Gln Glu Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys 
        195                 200                 205             


Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala 
    210                 215                 220                 


Ser Ser Ser Arg Met Gly Asp Ser Ser Gln Gly Asp Asn Asn Thr Gln 
225                 230                 235                 240 


Lys Leu Gly Pro Asp Asp Val Thr Val Asp Ile Asp Ala Ile Arg Arg 
                245                 250                 255     


Val Tyr Ser Ser Leu Leu Ala Asn Glu Lys Leu Glu Thr Ala Phe Leu 
            260                 265                 270         


Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr 
        275                 280                 285             


His Asn Val Tyr Thr Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile 
    290                 295                 300                 


Val Met Glu Asn Ser Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala 
305                 310                 315                 320 


Leu Pro Leu Phe Cys Lys Ala Met Cys Lys Leu Pro Leu Glu Ala Gln 
                325                 330                 335     


Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Ser Ala Asp Gln Ile Arg 
            340                 345                 350         


Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser 
        355                 360                 365             


Asn Glu Phe Asn Ser Thr Asn Leu Val Asn Asp Asp Asp Ala Ile Val 
    370                 375                 380                 


Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly 
385                 390                 395                 400 


Gly Asp Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile 
                405                 410                 415     


Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Asp Glu Arg 
            420                 425                 430         


Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly 
        435                 440                 445             


Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Ser Phe Glu Glu Phe 
    450                 455                 460                 


Ile Asn Glu Pro Leu Asn Asp Val Leu Glu Met Asp Lys Asp Tyr Thr 
465                 470                 475                 480 


Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro 
                485                 490                 495     


Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn 
            500                 505                 510         


Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu 
        515                 520                 525             


Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg 
    530                 535                 540                 


Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met 
545                 550                 555                 560 


Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly 
                565                 570                 575     


Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu 
            580                 585                 590         


Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp 
        595                 600                 605             


Asn Asn Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu 
    610                 615                 620                 


Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn 
625                 630                 635                 640 


Asn Thr Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu 
                645                 650                 655     


Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val 
            660                 665                 670         


Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Ser Val Glu 
        675                 680                 685             


Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly 
    690                 695                 700                 


Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile 
705                 710                 715                 720 


Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile 
                725                 730                 735     


Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe 
            740                 745                 750         


His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu 
        755                 760                 765             


Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala 
    770                 775                 780                 


Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Glu Ser Val 
785                 790                 795                 800 


Val Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln 
                805                 810                 815     


Lys Arg Leu Phe Leu Gln Asn Thr Thr Gly Thr Asp Arg Ala Pro Val 
            820                 825                 830         


Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp 
        835                 840                 845             


Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu 
    850                 855                 860                 


Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala 
865                 870                 875                 880 


Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
                885                 890 


<210> 27
<211> 2673
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

atggccacag cttgtaaaag atcaccagga gaatcccagt ctgaggacat tgaagctagc      120

cgaatgaagc gagcagctgc aaagcatcta atagaacgct actaccatca gttaactgag      180

ggctgtggaa atgaggcctg cacgaatgag ttttgtgctt cctgtccaac ttttcttcgt      240

atggataaca atacagcagc tattaaagcc cttgagcttt ataaaattaa tgcaaaactc      300

tgtgatcctc atccctccaa gaaaggagca agctcagctt accttgagaa ctcaacaggt      360

gcatctaaca acacagagat aaaaatgaac aagaaggaag gaaaagattt taaagatgtg      420

atttacctaa ctgaagagaa agtatatgaa atttatgaat tttgtagaga gagtgaggat      480

tattcccctt taattcgtgt aattggaaga atattttcta gtgctgaggc actggttctg      540

agctttcgga aagtcaaaca gcacacaaag gaggaattga aatctcttca agaaaaggat      600

gaagacaagg atgaagatga aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa      660

gactcagaag catcttcttc aaggatgggt gatagttcac agggagacaa caatacacaa      720

aaattaggtc ctgatgatgt gactgtggat attgatgcta ttagaagggt ctacagcagt      780

ttgctcgcta atgaaaaatt agaaactgcc ttcctgaatg cacttgtata tctgtcacct      840

aacgtggaat gtgatttgac atatcataat gtgtatactc gagatcctaa ttatctcaat      900

ttgttcatta ttgtaatgga gaatagtaat ctccacagtc ctgaatatct ggaaatggcg      960

ttgccattat tttgcaaagc tatgtgtaag ctaccccttg aagctcaagg aaaactgatt     1020

aggctgtggt ctaaatacag tgctgaccag attcggagaa tgatggaaac atttcagcaa     1080

cttattacct acaaagtcat aagcaatgaa tttaatagca caaatctagt gaatgatgat     1140

gatgccattg ttgctgcttc aaagtgtttg aaaatggttt actatgcaaa tgtagtggga     1200

ggggatgtgg acacaaatca taatgaggaa gatgatgaag aacccatacc tgagtccagc     1260

gaattaacac ttcaggagct tctgggagat gaaagaagaa ataagaaagg tcctcgagtg     1320

gatccactag aaaccgaact tggcgttaaa actctagact gtcgaaaacc acttatctcc     1380

tttgaagaat tcattaatga accactgaat gatgttctag aaatggacaa agattatacc     1440

tttttcaaag ttgaaacaga gaacaaattc tcttttatga catgtccctt tatattgaat     1500

gctgtcacaa agaatctggg attatattat gacaatagaa ttcgcatgta cagtgaaaga     1560

agaatcactg ttctttacag cctagttcaa ggacagcagt tgaatccgta tttgagactc     1620

aaagtcagac gtgaccatat tatagatgat gcactggtcc ggctagagat gattgctatg     1680

gaaaatcctg cagacttgaa gaagcagttg tatgtggaat ttgaaggaga acaaggagta     1740

gatgagggag gcgtttccaa agagtttttt cagttggttg tggaggaaat ttttaatcca     1800

gatattggta tgttcacata tgataataat acgaaattat tttggtttaa tccatcttct     1860

tttgaaactg agggtcagtt tactctgatt ggcatagtcc tgggtctggc tatttacaat     1920

aatactatac tggatgtcca ttttcccatg gttgtataca ggaagctaat ggggaaaaaa     1980

ggaacctttc gtgacttggg agactctcac ccagttttat atcagagttt aaaggattta     2040

ttggaatatg aagggagtgt ggaagatgat atgatgatca ctttccagat atcacagaca     2100

gatctttttg gtaacccaat gatgtatgat ctaaaagaaa atggtgataa aattccaatt     2160

acaaatgaaa acaggaagga atttgtcaat ctctattcag actacattct caataaatct     2220

gtagaaaaac aattcaaggc atttcgcaga ggttttcata tggtgactaa tgaatcgccc     2280

ttaaaatact tattcagacc agaagaaatt gaattgctta tatgtggaag ccggaatcta     2340

gatttccagg cactagaaga aactacagag tatgacggtg gctatacgag ggaatctgtt     2400

gtgattaggg agttctggga aattgttcat tcgtttacag atgaacagaa aagactcttt     2460

ctgcagaata caacaggcac agacagagca cctgttggag gactaggaaa attgaagatg     2520

attatagcca aaaatggccc agacacagaa aggttaccta catctcatac ttgctttaat     2580

gtccttttac ttccggaata ttcaagcaaa gaaaaactta aagagagatt gttgaaggcc     2640

atcacatatg ccaaaggatt tggcatgctg taa                                  2673


<210> 28
<211> 890
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Met Ala Thr Ala Cys Lys Arg Ser Pro Gly Glu Ser 
            20                  25                  30          


Gln Ser Glu Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys 
        35                  40                  45              


His Leu Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn 
    50                  55                  60                  


Glu Ala Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg 
65                  70                  75                  80  


Met Asp Asn Asn Thr Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile 
                85                  90                  95      


Asn Ala Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser 
            100                 105                 110         


Ala Tyr Leu Glu Asn Ser Thr Gly Ala Ser Asn Asn Thr Glu Ile Lys 
        115                 120                 125             


Met Asn Lys Lys Glu Gly Lys Asp Phe Lys Asp Val Ile Tyr Leu Thr 
    130                 135                 140                 


Glu Glu Lys Val Tyr Glu Ile Tyr Glu Phe Cys Arg Glu Ser Glu Asp 
145                 150                 155                 160 


Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Ile Phe Ser Ser Ala Glu 
                165                 170                 175     


Ala Leu Val Leu Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu 
            180                 185                 190         


Leu Lys Ser Leu Gln Glu Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys 
        195                 200                 205             


Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala 
    210                 215                 220                 


Ser Ser Ser Arg Met Gly Asp Ser Ser Gln Gly Asp Asn Asn Thr Gln 
225                 230                 235                 240 


Lys Leu Gly Pro Asp Asp Val Thr Val Asp Ile Asp Ala Ile Arg Arg 
                245                 250                 255     


Val Tyr Ser Ser Leu Leu Ala Asn Glu Lys Leu Glu Thr Ala Phe Leu 
            260                 265                 270         


Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr 
        275                 280                 285             


His Asn Val Tyr Thr Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile 
    290                 295                 300                 


Val Met Glu Asn Ser Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala 
305                 310                 315                 320 


Leu Pro Leu Phe Cys Lys Ala Met Cys Lys Leu Pro Leu Glu Ala Gln 
                325                 330                 335     


Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Ser Ala Asp Gln Ile Arg 
            340                 345                 350         


Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser 
        355                 360                 365             


Asn Glu Phe Asn Ser Thr Asn Leu Val Asn Asp Asp Asp Ala Ile Val 
    370                 375                 380                 


Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly 
385                 390                 395                 400 


Gly Asp Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile 
                405                 410                 415     


Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Asp Glu Arg 
            420                 425                 430         


Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly 
        435                 440                 445             


Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Ser Phe Glu Glu Phe 
    450                 455                 460                 


Ile Asn Glu Pro Leu Asn Asp Val Leu Glu Met Asp Lys Asp Tyr Thr 
465                 470                 475                 480 


Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro 
                485                 490                 495     


Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn 
            500                 505                 510         


Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu 
        515                 520                 525             


Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg 
    530                 535                 540                 


Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met 
545                 550                 555                 560 


Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly 
                565                 570                 575     


Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu 
            580                 585                 590         


Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp 
        595                 600                 605             


Asn Asn Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu 
    610                 615                 620                 


Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn 
625                 630                 635                 640 


Asn Thr Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu 
                645                 650                 655     


Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val 
            660                 665                 670         


Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Ser Val Glu 
        675                 680                 685             


Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly 
    690                 695                 700                 


Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile 
705                 710                 715                 720 


Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile 
                725                 730                 735     


Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe 
            740                 745                 750         


His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu 
        755                 760                 765             


Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala 
    770                 775                 780                 


Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Glu Ser Val 
785                 790                 795                 800 


Val Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln 
                805                 810                 815     


Lys Arg Leu Phe Leu Gln Asn Thr Thr Gly Thr Asp Arg Ala Pro Val 
            820                 825                 830         


Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp 
        835                 840                 845             


Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu 
    850                 855                 860                 


Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala 
865                 870                 875                 880 


Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
                885                 890 


<210> 29
<211> 2610
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

atgaagcgag cagctgcaaa gcatctaata gaacgctact accatcagtt aactgagggc      120

tgtggaaatg aggcctgcac gaatgagttt tgtgcttcct gtccaacttt tcttcgtatg      180

gataacaata cagcagctat taaagccctt gagctttata aaattaatgc aaaactctgt      240

gatcctcatc cctccaagaa aggagcaagc tcagcttacc ttgagaactc aacaggtgca      300

tctaacaaca cagagataaa aatgaacaag aaggaaggaa aagattttaa agatgtgatt      360

tacctaactg aagagaaagt atatgaaatt tatgaatttt gtagagagag tgaggattat      420

tcccctttaa ttcgtgtaat tggaagaata ttttctagtg ctgaggcact ggttctgagc      480

tttcggaaag tcaaacagca cacaaaggag gaattgaaat ctcttcaaga aaaggatgaa      540

gacaaggatg aagatgaaaa ggaaaaagct gcatgttctg ctgctgctat ggaagaagac      600

tcagaagcat cttcttcaag gatgggtgat agttcacagg gagacaacaa tacacaaaaa      660

ttaggtcctg atgatgtgac tgtggatatt gatgctatta gaagggtcta cagcagtttg      720

ctcgctaatg aaaaattaga aactgccttc ctgaatgcac ttgtatatct gtcacctaac      780

gtggaatgtg atttgacata tcataatgtg tatactcgag atcctaatta tctcaatttg      840

ttcattattg taatggagaa tagtaatctc cacagtcctg aatatctgga aatggcgttg      900

ccattatttt gcaaagctat gtgtaagcta ccccttgaag ctcaaggaaa actgattagg      960

ctgtggtcta aatacagtgc tgaccagatt cggagaatga tggaaacatt tcagcaactt     1020

attacctaca aagtcataag caatgaattt aatagcacaa atctagtgaa tgatgatgat     1080

gccattgttg ctgcttcaaa gtgtttgaaa atggtttact atgcaaatgt agtgggaggg     1140

gatgtggaca caaatcataa tgaggaagat gatgaagaac ccatacctga gtccagcgaa     1200

ttaacacttc aggagcttct gggagatgaa agaagaaata agaaaggtcc tcgagtggat     1260

ccactagaaa ccgaacttgg cgttaaaact ctagactgtc gaaaaccact tatctccttt     1320

gaagaattca ttaatgaacc actgaatgat gttctagaaa tggacaaaga ttataccttt     1380

ttcaaagttg aaacagagaa caaattctct tttatgacat gtccctttat attgaatgct     1440

gtcacaaaga atctgggatt atattatgac aatagaattc gcatgtacag tgaaagaaga     1500

atcactgttc tttacagcct agttcaagga cagcagttga atccgtattt gagactcaaa     1560

gtcagacgtg accatattat agatgatgca ctggtccggc tagagatgat tgctatggaa     1620

aatcctgcag acttgaagaa gcagttgtat gtggaatttg aaggagaaca aggagtagat     1680

gagggaggcg tttccaaaga gttttttcag ttggttgtgg aggaaatttt taatccagat     1740

attggtatgt tcacatatga taataatacg aaattatttt ggtttaatcc atcttctttt     1800

gaaactgagg gtcagtttac tctgattggc atagtcctgg gtctggctat ttacaataat     1860

actatactgg atgtccattt tcccatggtt gtatacagga agctaatggg gaaaaaagga     1920

acctttcgtg acttgggaga ctctcaccca gttttatatc agagtttaaa ggatttattg     1980

gaatatgaag ggagtgtgga agatgatatg atgatcactt tccagatatc acagacagat     2040

ctttttggta acccaatgat gtatgatcta aaagaaaatg gtgataaaat tccaattaca     2100

aatgaaaaca ggaaggaatt tgtcaatctc tattcagact acattctcaa taaatctgta     2160

gaaaaacaat tcaaggcatt tcgcagaggt tttcatatgg tgactaatga atcgccctta     2220

aaatacttat tcagaccaga agaaattgaa ttgcttatat gtggaagccg gaatctagat     2280

ttccaggcac tagaagaaac tacagagtat gacggtggct atacgaggga atctgttgtg     2340

attagggagt tctgggaaat tgttcattcg tttacagatg aacagaaaag actctttctg     2400

cagaatacaa caggcacaga cagagcacct gttggaggac taggaaaatt gaagatgatt     2460

atagccaaaa atggcccaga cacagaaagg ttacctacat ctcatacttg ctttaatgtc     2520

cttttacttc cggaatattc aagcaaagaa aaacttaaag agagattgtt gaaggccatc     2580

acatatgcca aaggatttgg catgctgtaa                                      2610


<210> 30
<211> 869
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg 
            20                  25                  30          


Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn 
        35                  40                  45              


Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Thr 
    50                  55                  60                  


Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys 
65                  70                  75                  80  


Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn 
                85                  90                  95      


Ser Thr Gly Ala Ser Asn Asn Thr Glu Ile Lys Met Asn Lys Lys Glu 
            100                 105                 110         


Gly Lys Asp Phe Lys Asp Val Ile Tyr Leu Thr Glu Glu Lys Val Tyr 
        115                 120                 125             


Glu Ile Tyr Glu Phe Cys Arg Glu Ser Glu Asp Tyr Ser Pro Leu Ile 
    130                 135                 140                 


Arg Val Ile Gly Arg Ile Phe Ser Ser Ala Glu Ala Leu Val Leu Ser 
145                 150                 155                 160 


Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu Gln 
                165                 170                 175     


Glu Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala Cys 
            180                 185                 190         


Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg Met 
        195                 200                 205             


Gly Asp Ser Ser Gln Gly Asp Asn Asn Thr Gln Lys Leu Gly Pro Asp 
    210                 215                 220                 


Asp Val Thr Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Ser Ser Leu 
225                 230                 235                 240 


Leu Ala Asn Glu Lys Leu Glu Thr Ala Phe Leu Asn Ala Leu Val Tyr 
                245                 250                 255     


Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr Thr 
            260                 265                 270         


Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn Ser 
        275                 280                 285             


Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe Cys 
    290                 295                 300                 


Lys Ala Met Cys Lys Leu Pro Leu Glu Ala Gln Gly Lys Leu Ile Arg 
305                 310                 315                 320 


Leu Trp Ser Lys Tyr Ser Ala Asp Gln Ile Arg Arg Met Met Glu Thr 
                325                 330                 335     


Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn Ser 
            340                 345                 350         


Thr Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys Cys 
        355                 360                 365             


Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Asp Val Asp Thr 
    370                 375                 380                 


Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser Glu 
385                 390                 395                 400 


Leu Thr Leu Gln Glu Leu Leu Gly Asp Glu Arg Arg Asn Lys Lys Gly 
                405                 410                 415     


Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu Asp 
            420                 425                 430         


Cys Arg Lys Pro Leu Ile Ser Phe Glu Glu Phe Ile Asn Glu Pro Leu 
        435                 440                 445             


Asn Asp Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val Glu 
    450                 455                 460                 


Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn Ala 
465                 470                 475                 480 


Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met Tyr 
                485                 490                 495     


Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln Gln 
            500                 505                 510         


Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile Asp 
        515                 520                 525             


Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala Asp 
    530                 535                 540                 


Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val Asp 
545                 550                 555                 560 


Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu Ile 
                565                 570                 575     


Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Asn Asn Thr Lys Leu 
            580                 585                 590         


Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr Leu 
        595                 600                 605             


Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Thr Ile Leu Asp 
    610                 615                 620                 


Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys Gly 
625                 630                 635                 640 


Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser Leu 
                645                 650                 655     


Lys Asp Leu Leu Glu Tyr Glu Gly Ser Val Glu Asp Asp Met Met Ile 
            660                 665                 670         


Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met Tyr 
        675                 680                 685             


Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn Arg 
    690                 695                 700                 


Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser Val 
705                 710                 715                 720 


Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr Asn 
                725                 730                 735     


Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu Leu 
            740                 745                 750         


Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr Thr 
        755                 760                 765             


Glu Tyr Asp Gly Gly Tyr Thr Arg Glu Ser Val Val Ile Arg Glu Phe 
    770                 775                 780                 


Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe Leu 
785                 790                 795                 800 


Gln Asn Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly Lys 
                805                 810                 815     


Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu Pro 
            820                 825                 830         


Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser Ser 
        835                 840                 845             


Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala Lys 
    850                 855                 860                 


Gly Phe Gly Met Leu 
865                 


<210> 31
<211> 2640
<212> DNA
<213> Homo sapiens

<400> 31
ctggtggaga ccagatcagg agaacctcag tctgacgaca ttgaagctag ccgaatgaag       60

cgagcagctg caaagcatct aatagaacgc tactaccacc agttaactga gggctgtgga      120

aatgaagcct gcacgaatga gttttgtgct tcctgtccaa cttttcttcg tatggataat      180

aatgcagcag ctattaaagc cctcgagctt tataagatta atgcaaaact ctgtgatcct      240

catccctcca agaaaggagc aagctcagct taccttgaga actcgaaagg tgcccccaac      300

aactcctgct ctgagataaa aatgaacaag aaaggcgcta gaattgattt taaagatgtg      360

acttacttaa cagaagagaa ggtatatgaa attcttgaat tatgtagaga aagagaggat      420

tattcccctt taatccgtgt tattggaaga gttttttcta gtgctgaggc attggtacag      480

agcttccgga aagttaaaca acacaccaag gaagaactga aatctcttca agcaaaagat      540

gaagacaaag atgaagatga aaaggaaaaa gctgcatgtt ctgctgctgc tatggaagaa      600

gactcagaag catcttcctc aaggataggt gatagctcac agggagacaa caatttgcaa      660

aaattaggcc ctgatgatgt gtctgtggat attgatgcca ttagaagggt ctacaccaga      720

ttgctctcta atgaaaaaat tgaaactgcc tttctcaatg cacttgtata tttgtcacct      780

aacgtggaat gtgacttgac gtatcacaat gtatactctc gagatcctaa ttatctgaat      840

ttgttcatta tcgtaatgga gaatagaaat ctccacagtc ctgaatatct ggaaatggct      900

ttgccattat tttgcaaagc gatgagcaag ctaccccttg cagcccaagg aaaactgatc      960

agactgtggt ctaaatacaa tgcagaccag attcggagaa tgatggagac atttcagcaa     1020

cttattactt ataaagtcat aagcaatgaa tttaacagtc gaaatctagt gaatgatgat     1080

gatgccattg ttgctgcttc gaagtgcttg aaaatggttt actatgcaaa tgtagtggga     1140

ggggaagtgg acacaaatca caatgaagaa gatgatgaag agcccatccc tgagtccagc     1200

gagctgacac ttcaggaact tttgggagaa gaaagaagaa acaagaaagg tcctcgagtg     1260

gaccccctgg aaactgaact tggtgttaaa accctggatt gtcgaaaacc acttatccct     1320

tttgaagagt ttattaatga accactgaat gaggttctag aaatggataa agattatact     1380

tttttcaaag tagaaacaga gaacaaattc tcttttatga catgtccctt tatattgaat     1440

gctgtcacaa agaatttggg attatattat gacaatagaa ttcgcatgta cagtgaacga     1500

agaatcactg ttctctacag cttagttcaa ggacagcagt tgaatccata tttgagactc     1560

aaagttagac gtgaccatat catagatgat gcacttgtcc ggctagagat gatcgctatg     1620

gaaaatcctg cagacttgaa gaagcagttg tatgtggaat ttgaaggaga acaaggagtt     1680

gatgagggag gtgtttccaa agaatttttt cagctggttg tggaggaaat cttcaatcca     1740

gatattggta tgttcacata cgatgaatct acaaaattgt tttggtttaa tccatcttct     1800

tttgaaactg agggtcagtt tactctgatt ggcatagtac tgggtctggc tatttacaat     1860

aactgtatac tggatgtaca ttttcccatg gttgtctaca ggaagctaat ggggaaaaaa     1920

ggaacttttc gtgacttggg agactctcac ccagttctat atcagagttt aaaagattta     1980

ttggagtatg aagggaatgt ggaagatgac atgatgatca ctttccagat atcacagaca     2040

gatctttttg gtaacccaat gatgtatgat ctaaaggaaa atggtgataa aattccaatt     2100

acaaatgaaa acaggaagga atttgtcaat ctttattctg actacattct caataaatca     2160

gtagaaaaac agttcaaggc ttttcggaga ggttttcata tggtgaccaa tgaatctccc     2220

ttaaagtact tattcagacc agaagaaatt gaattgctta tatgtggaag ccggaatcta     2280

gatttccaag cactagaaga aactacagaa tatgacggtg gctataccag ggactctgtt     2340

ctgattaggg agttctggga aatcgttcat tcatttacag atgaacagaa aagactcttc     2400

ttgcagttta caacgggcac agacagagca cctgtgggag gactaggaaa attaaagatg     2460

attatagcca aaaatggccc agacacagaa aggttaccta catctcatac ttgctttaat     2520

gtgcttttac ttccggaata ctcaagcaaa gaaaaactta aagagagatt gttgaaggcc     2580

atcacgtatg ccaaaggatt tggcatgctg taaaacaaaa caaaacaaaa taaaacaaaa     2640


<210> 32
<211> 870
<212> PRT
<213> Homo sapiens

<400> 32
Leu Val Glu Thr Arg Ser Gly Glu Pro Gln Ser Asp Asp Ile Glu Ala 
1               5                   10                  15      


Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg Tyr Tyr 
            20                  25                  30          


His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn Glu Phe 
        35                  40                  45              


Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala Ala Ala 
    50                  55                  60                  


Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys Asp Pro 
65                  70                  75                  80  


His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn Ser Lys 
                85                  90                  95      


Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys Lys Gly 
            100                 105                 110         


Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu Lys Val 
        115                 120                 125             


Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser Pro Leu 
    130                 135                 140                 


Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu Val Gln 
145                 150                 155                 160 


Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys Ser Leu 
                165                 170                 175     


Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys Ala Ala 
            180                 185                 190         


Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser Ser Arg 
        195                 200                 205             


Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu Gly Pro 
    210                 215                 220                 


Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr Thr Arg 
225                 230                 235                 240 


Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala Leu Val 
                245                 250                 255     


Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn Val Tyr 
            260                 265                 270         


Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met Glu Asn 
        275                 280                 285             


Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro Leu Phe 
    290                 295                 300                 


Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys Leu Ile 
305                 310                 315                 320 


Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met Met Glu 
                325                 330                 335     


Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu Phe Asn 
            340                 345                 350         


Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala Ser Lys 
        355                 360                 365             


Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu Val Asp 
    370                 375                 380                 


Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu Ser Ser 
385                 390                 395                 400 


Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn Lys Lys 
                405                 410                 415     


Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys Thr Leu 
            420                 425                 430         


Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn Glu Pro 
        435                 440                 445             


Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe Lys Val 
    450                 455                 460                 


Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile Leu Asn 
465                 470                 475                 480 


Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile Arg Met 
                485                 490                 495     


Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln Gly Gln 
            500                 505                 510         


Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His Ile Ile 
        515                 520                 525             


Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn Pro Ala 
    530                 535                 540                 


Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln Gly Val 
545                 550                 555                 560 


Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val Glu Glu 
                565                 570                 575     


Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser Thr Lys 
            580                 585                 590         


Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln Phe Thr 
        595                 600                 605             


Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys Ile Leu 
    610                 615                 620                 


Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly Lys Lys 
625                 630                 635                 640 


Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr Gln Ser 
                645                 650                 655     


Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp Met Met 
            660                 665                 670         


Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro Met Met 
        675                 680                 685             


Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn Glu Asn 
    690                 695                 700                 


Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn Lys Ser 
705                 710                 715                 720 


Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met Val Thr 
                725                 730                 735     


Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile Glu Leu 
            740                 745                 750         


Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln Ala Leu Glu Glu Thr 
        755                 760                 765             


Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile Arg Glu 
    770                 775                 780                 


Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg Leu Phe 
785                 790                 795                 800 


Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly Leu Gly 
                805                 810                 815     


Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu Arg Leu 
            820                 825                 830         


Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu Tyr Ser 
        835                 840                 845             


Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr Tyr Ala 
    850                 855                 860                 


Lys Gly Phe Gly Met Leu 
865                 870 


<210> 33
<211> 9
<212> PRT
<213> Homo sapiens

<400> 33
Asn Lys Thr Lys Gln Asn Lys Thr Lys 
1               5                   


<210> 34
<211> 523
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggtttgtgg cagtacatca atgggcgtgg atagcggttt gactcacggg      360

gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac      420

gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg      480

tacggtggga ggtctatata agcagagctc gtttagtgaa ccg                        523


<210> 35
<211> 6612
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac       60

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa      120

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat      180

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc      240

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga      300

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg      360

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc      420

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag      480

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc      540

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg      600

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg      660

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac      720

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac      780

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg      840

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg      900

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg      960

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     1020

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     1080

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     1140

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     1200

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     1260

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtc cttctagtgt     1320

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     1380

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     1440

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     1500

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     1560

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     1620

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     1680

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     1740

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     1800

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     1860

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     1920

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     1980

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     2040

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     2100

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     2160

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagcttggc     2220

cattgcatac gttgtatcca tatcataata tgtacattta tattggctca tgtccaacat     2280

taccgccatg ttgacattga ttattgacta gttattaata gtaatcaatt acggggtcat     2340

tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg     2400

gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa     2460

cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact     2520

tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc aatgacggta     2580

aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct acttggcagt     2640

acatctacgt attagtcatc gctattacca tggtgatgcg gtttgtggca gtacatcaat     2700

gggcgtggat agcggtttga ctcacgggga tttccaagtc tccaccccat tgacgtcaat     2760

gggagtttgt tttggcacca aaatcaacgg gactttccaa aatgtcgtaa caactccgcc     2820

ccattgacgc aaatgggcgg taggcgtgta cggtgggagg tctatataag cagagctcgt     2880

ttagtgaacc ggggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac     2940

tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg     3000

cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga     3060

aaatctctag cagtggcgcc cgaacaggga cctgaaagcg aaagggaaac cagaggagct     3120

ctctcgacgc aggactcggc ttgctgaagc gcgcacggca agaggcgagg ggcggcgact     3180

ggtgagtacg ccaaaaattt tgactagcgg aggctagaag gagagagatg ggtgcgagag     3240

cgtcagtatt aagcggggga gaattagatc gcgatgggaa aaaattcggt taaggccagg     3300

gggaaagaaa aaatataaat taaaacatat agtatgggca agcagggagc tagaacgatt     3360

cgcagttaat cctggcctgt tagaaacatc agaaggctgt agacaaatac tgggacagct     3420

acaaccatcc cttcagacag gatcagaaga acttagatca ttatataata cagtagcaac     3480

cctctattgt gtgcatcaaa ggatagagat aaaagacacc aaggaagctt tagacaagat     3540

agaggaagag caaaacaaaa gtaagaccac cgcacagcaa gcggccgctg atcttcagac     3600

ctggaggagg agatatgagg gacaattgga gaagtgaatt atataaatat aaagtagtaa     3660

aaattgaacc attaggagta gcacccacca aggcaaagag aagagtggtg cagagagaaa     3720

aaagagcagt gggaatagga gctttgttcc ttgggttctt gggagcagca ggaagcacta     3780

tgggcgcagc gtcaatgacg ctgacggtac aggccagaca attattgtct ggtatagtgc     3840

agcagcagaa caatttgctg agggctattg aggcgcaaca gcatctgttg caactcacag     3900

tctggggcat caagcagctc caggcaagaa tcctggctgt ggaaagatac ctaaaggatc     3960

aacagctcct ggggatttgg ggttgctctg gaaaactcat ttgcaccact gctgtgcctt     4020

ggaatgctag ttggagtaat aaatctctgg aacagattgg aatcacacga cctggatgga     4080

gtgggacaga gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca     4140

aaaccagcaa gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg     4200

gaattggttt aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg     4260

aggcttggta ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca     4320

gggatattca ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccgacaggcc     4380

cgaaggaata gaagaagaag gtggagagag agacagagac agatccattc gattagtgaa     4440

cggatctcga cggtatcgat aagctaattc acaaatggca gtattcatcc acaattttaa     4500

aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca taatagcaac     4560

agacatacaa actaaagaat tacaaaaaca aattacaaaa attcaaaatt ttcgggttta     4620

ttacagggac agcagagatc cagtttggga attagcttga tcgattagtc caatttgtta     4680

aagacaggat atcagtggtc caggctctag ttttgactca acaatatcac cagctgaagc     4740

ctatagagta cgagccatag atagaataaa agattttatt tagtctccag aaaaaggggg     4800

gaatgaaaga ccccacctgt aggtttggca agctaggatc aaggttagga acagagagac     4860

agcagaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc     4920

aagaacagtt ggaacagcag aatatgggcc aaacaggata tctgtggtaa gcagttcctg     4980

ccccggctca gggccaagaa cagatggtcc ccagatgcgg tcccgccctc agcagtttct     5040

agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt     5100

tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttctgctc cccgagctca     5160

ataaaagagc ccacaacccc tcactcggcg cgatctagat ctcgaatcga attcgccctt     5220

gttaacagat cccccgggtc gactgatcaa attcgagctc ggtaccttta agaccaatga     5280

cttacaaggc agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc     5340

taattcactc ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag     5400

accagatctg agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat     5460

aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact     5520

agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc     5580

atcttattat tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact     5640

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata     5700

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc     5760

atgtctggct ctagctatcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag     5820

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     5880

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt     5940

ttgcgtcgag acgtacccaa ttcgccctat agtgagtcgt attacgcgcg ctcactggcc     6000

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     6060

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     6120

caacagttgc gcagcctgaa tggcgaatgg cgcgacgcgc cctgtagcgg cgcattaagc     6180

gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc     6240

gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct     6300

ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa     6360

aaacttgatt agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc     6420

cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca     6480

ctcaacccta tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat     6540

tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg     6600

tttacaattt cc                                                         6612


