                         SEQUENCE LISTING

<110>  Martin, Aaron
       Baeuerle, Patrick Alexander
       Hofmeister, Robert
       Getts, Daniel
       Kieffer-Kwon, Philippe
       Donaghey, Julie
 
<120>  COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION 
       PROTEINS

<130>  4428.001PC01

<150>  US 62/889,987 
<151>  2019-08-21

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
1               5                   10                  15      


Glu 
    


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Leu Glu 
            20  


<210>  3
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
            20                  25                  30  


<210>  4
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  5
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  6
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Ser 
                165                 170         


<210>  7
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  8
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Thr Trp Leu Leu Leu Leu Leu Ala Leu Gly Cys Pro Ala 
1               5                   10                  15      


Leu Pro Thr Gly Val Gly Gly Thr Pro Phe Pro Ser Leu Ala Pro Pro 
            20                  25                  30          


Ile Met Leu Leu Val Asp Gly Lys Gln Gln Met Val Val Val Cys Leu 
        35                  40                  45              


Val Leu Asp Val Ala Pro Pro Gly Leu Asp Ser Pro Ile Trp Phe Ser 
    50                  55                  60                  


Ala Gly Asn Gly Ser Ala Leu Asp Ala Phe Thr Tyr Gly Pro Ser Pro 
65                  70                  75                  80  


Ala Thr Asp Gly Thr Trp Thr Asn Leu Ala His Leu Ser Leu Pro Ser 
                85                  90                  95      


Glu Glu Leu Ala Ser Trp Glu Pro Leu Val Cys His Thr Gly Pro Gly 
            100                 105                 110         


Ala Glu Gly His Ser Arg Ser Thr Gln Pro Met His Leu Ser Gly Glu 
        115                 120                 125             


Ala Ser Thr Ala Arg Thr Cys Pro Gln Glu Pro Leu Arg Gly Thr Pro 
    130                 135                 140                 


Gly Gly Ala Leu Trp Leu Gly Val Leu Arg Leu Leu Leu Phe Lys Leu 
145                 150                 155                 160 


Leu Leu Phe Asp Leu Leu Leu Thr Cys Ser Cys Leu Cys Asp Pro Ala 
                165                 170                 175     


Gly Pro Leu Pro Ser Pro Ala Thr Thr Thr Arg Leu Arg Ala Leu Gly 
            180                 185                 190         


Ser His Arg Leu His Pro Ala Thr Glu Thr Gly Gly Arg Glu Ala Thr 
        195                 200                 205             


Ser Ser Pro Arg Pro Gln Pro Arg Asp Arg Arg Trp Gly Asp Thr Pro 
    210                 215                 220                 


Pro Gly Arg Lys Pro Gly Ser Pro Val Trp Gly Glu Gly Ser Tyr Leu 
225                 230                 235                 240 


Ser Ser Tyr Pro Thr Cys Pro Ala Gln Ala Trp Cys Ser Arg Ser Ala 
                245                 250                 255     


Leu Arg Ala Pro Ser Ser Ser Leu Gly Ala Phe Phe Ala Gly Asp Leu 
            260                 265                 270         


Pro Pro Pro Leu Gln Ala Gly Ala 
        275                 280 


<210>  9
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser 
1               5                   10                  15      


Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln 
            20                  25                  30          


Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys 
        35                  40                  45              


Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val 
    50                  55                  60                  


Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn 
65                  70                  75                  80  


Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys 
                85                  90                  95      


Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn 
            100                 105                 110         


Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val 
        115                 120                 125             


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140         


<210>  10
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Lys Gly Ala Gly Thr Ala Ser Lys Leu Thr 
        115                 120                 125             


Phe Gly Thr Gly Thr Arg Leu Gln Val Thr Leu 
    130                 135                 


<210>  11
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
            100                 105                 110         


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp 
                165                 170                 175     


Phe 
    


<210>  12
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Asn Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Ala Gly Leu Asn Gln Pro Gln His Phe Gly Asp Gly Thr 
        115                 120                 125             


Arg Leu Ser Ile Leu 
    130             


<210>  13
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Phe Ser Thr Cys Ser Ala Asn Tyr Gly Tyr Thr Phe Gly Ser 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val 
    130                 135 


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14
agggcaagtc aggacattag taaa                                              24


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Arg Ala Ser Gln Asp Ile Ser Lys 
1               5               


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16
atctaccata catcaagatt a                                                 21


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Ile Tyr His Thr Ser Arg Leu 
1               5           


<210>  18
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18
caacagggta atacgcttcc gtacacg                                           27


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
1               5                   


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20
ggggtctcat tacccgacta tggtgtaagc                                        30


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
1               5                   10  


<210>  22
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22
gtaatatggg gtagtgaaac cacatactat aattcagctc tc                          42


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu 
1               5                   10                  


<210>  24
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24
cattattact acggtggtag ctatgctatg gactac                                 36


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggactaagt tggaaataac a                                                321


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
            100                 105         


<210>  28
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28
gaggtgaaac tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccgtc       60

acatgcactg tctcaggggt ctcattaccc gactatggtg taagctggat tcgccagcct      120

ccacgaaagg gtctggagtg gctgggagta atatggggta gtgaaaccac atactataat      180

tcagctctca aatccagact gaccatcatc aaggacaact ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatttact actgtgccaa acattattac      300

tacggtggta gctatgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29

Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  30
tggcctggag caacaaatct ga                                                22


<210>  31
<211>  164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  31
gggcggagtt agggcggagc caatcagcgt gcgccgttcc gaaagttgcc ttttatggct       60

gggcggagaa tgggcggtga acgccgatga ttatataagg acgcgccggg tgtggcacag      120

ctagttccgt cgcagccggg atttgggtcg cggttcttgt ttgt                       164


<210>  32
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  32
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga      120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag      180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc      240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg      300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc      360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct      420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg      480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt      540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt      600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac      660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac      720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga      780

acctcagtca ccgtctcctc a                                                801


<210>  33
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  33

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210>  34
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34
gccacaaatt tctcactgct gaaacaggcc ggcgacgtgg aagagaaccc tggacct          57


<210>  35
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35
cgggccaaga ga                                                           12


<210>  36
<211>  242
<212>  DNA
<213>  Homo sapiens

<400>  36
gggaaatgag atcatgtcct aaccctgatc ctcttgtccc acagatatcc agaaccctga       60

ccctgccgtg taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac      120

cgattttgat tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga      180

caaaactgtg ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag      240

ca                                                                     242


<210>  37
<211>  192
<212>  DNA
<213>  Homo sapiens

<400>  37
gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca       60

ccttcttccc cagcccaggt aagggcagct ttggtgcctt cgcaggctgt ttccttgctt      120

caggaatggc caggttctgc ccagagctct ggtcaatgat gtctaaaact cctctgattg      180

gtggtctcgg cc                                                          192


<210>  38
<211>  420
<212>  DNA
<213>  Homo sapiens

<400>  38
atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct       60

gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat      120

gtgtatatca cagacaaaac tgtgctagac atgaggtcta tggacttcaa gagcaacagt      180

gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt      240

attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag      300

aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga      360

atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc      420


<210>  39
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  39
gacctgaaca aggtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc       60

tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttcttccc cgaccacgtg      120

gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtcagcac ggacccgcag      180

cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg      240

gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac      300

gggctctcgg agaatgacga gtggacccag gatagggcca aacccgtcac ccagatcgtc      360

agcgccgagg cctggggtag agcagactgt ggctttacct cggtgtccta ccagcaaggg      420

gtcctgtctg ccaccatcct ctatgagatc ctgctaggga aggccaccct gtatgctgtg      480

ctggtcagcg cccttgtgtt gatggccatg gtcaagagaa aggatttctg ataa            534


<210>  40
<211>  411
<212>  DNA
<213>  Mus musculus

<400>  40
aacattcaga accctgagcc tgccgtgtac cagctgaagg accctagaag ccaggacagc       60

accctgtgcc tgttcaccga cttcgacagc cagatcaacg tgcccaagac catggaaagc      120

ggcaccttca tcaccgataa gtgcgtgctg gacatgaagg ccatggacag caagagcaac      180

ggcgccattg cctggtccaa tcagaccagc tttacctgcc aagacatctt caaagagaca      240

aacgccacct atcctagcag cgacgtgccc tgtgatgcca cactgaccga gaagtccttc      300

gagacagaca tgaacctgaa cttccagaac ctgctggtca tcgtgctgcg gatcctgctt      360

ctgaaggtgg ccggcttcaa tctgctgatg accctgcgac tgtggtccag c               411


<210>  41
<211>  519
<212>  DNA
<213>  Mus musculus

<400>  41
gaagatctga gaaacgtgac ccctcctaag gtgtccctgt tcgagcctag caaggccgag       60

atcgccaaca agcagaaagc cacactcgtg tgcctggcca gaggcttctt tcccgatcac      120

gtggaactgt cttggtgggt caacggcaaa gaggtgcaca gcggcgtctg tactgatccc      180

caggcctaca aagagagcaa ctactcctac tgcctgagca gcagactgag agtgtccgcc      240

accttctggc acaaccccag aaaccacttc agatgccagg tgcagtttca cggcctgagc      300

gaagaggaca agtggcctga gggaagcccc aagcctgtga cacagaatat ctctgccgaa      360

gcctggggca gagccgattg tggaattacc agcgccagtt accagcaggg cgtgctgtct      420

gccacaatcc tgtatgagat cctgctgggc aaagccactc tgtacgccgt gctggtgtct      480

accctggtcg tgatggccat ggtcaagcgg aagaacagc                             519


<210>  42
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  42
gatggtaatg aagaaatggg tggtattaca cagacaccat ataaagtctc catctctgga       60

accacagtaa tattgacatg ccctcagtat cctggatctg aaatactatg gcaacacaat      120

gataaaaaca taggcggtga tgaggatgat aaaaacatag gcagtgatga ggatcacctg      180

tcactgaagg aattttcaga attggagcaa agtggttatt atgtctgcta ccccagagga      240

agcaaaccag aagatgcgaa cttttatctc tacctgaggg caagagtgtg tgagaactgc      300

atggagatgg atgtgatgtc ggtggccaca attgtcatag tggacatctg catcactggg      360

ggcttgctgc tgctggttta ctactggagc aagaatagaa aggccaaggc caagcctgtg      420

acacgaggag cgggtgctgg cggcaggcaa aggggacaaa acaaggagag gccaccacct      480

gttcccaacc cagactatga gcccatccgg aaaggccagc gggacctgta ttctggcctg      540

aatcagagac gcatc                                                       555


