
                                SEQUENCE LISTING

<110> Fred Hutchinson Cancer Research Center
      Schmitt, Thomas M.
      Chapuis, Aude G.
      Greenberg, Philip D.

<120> 360056.473WO

<130> T-CELL IMMUNOTHERAPY SPECIFIC FOR WT-1

<140> PCT
<141> 2020-08-19

<150> US 62/889,519
<151> 2019-08-20

<160> 124

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 alpha chain variable
      domain with leader sequence

<400> 1
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Asn Ile Gly Asn His Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr
        115                 120                 125
Val Lys Pro Asn
    130

<210> 2
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 alpha chain variable
      domain with leader sequence

<400> 2
Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu
 1               5                  10                  15
Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu
            20                  25                  30
Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val
        35                  40                  45
Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly
    50                  55                  60
Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys
65                  70                  75                  80
Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile
                85                  90                  95
Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln
            100                 105                 110
Thr Met Asp Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr
        115                 120                 125
Val Ile Pro Asn
    130

<210> 3
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 alpha chain variable
      domain with leader sequence

<400> 3
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu
 1               5                  10                  15
Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
            20                  25                  30
Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
    50                  55                  60
Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                85                  90                  95
Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys
            100                 105                 110
Ala Ser Ser Pro Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg
        115                 120                 125
Leu Lys Val Leu Ala Asn
    130

<210> 4
<211> 137
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 alpha chain variable
      domain with leader sequence

<400> 4
Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu
 1               5                  10                  15
Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
            20                  25                  30
Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Glu Ser Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
    50                  55                  60
Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                85                  90                  95
Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys
            100                 105                 110
Ala Phe Asn Pro Trp Glu Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro
        115                 120                 125
Gly Thr Arg Leu Ser Val Leu Pro Tyr
    130                 135

<210> 5
<211> 134
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta chain variable
      domain with leader sequence

<400> 5
Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Val Pro Ile Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met
            20                  25                  30
Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His
        35                  40                  45
Arg Ala Met Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu
    50                  55                  60
Met Phe Val Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro
65                  70                  75                  80
Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His
                85                  90                  95
Leu His Ala Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gln Gly Thr Ser Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu
    130

<210> 6
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta chain variable
      domain with leader sequence

<400> 6
Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu
            20                  25                  30
Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His
        35                  40                  45
Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
    50                  55                  60
Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro
65                  70                  75                  80
Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg
                85                  90                  95
Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Tyr Ser Leu Trp Asp Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Leu Val Leu Glu
    130                 135

<210> 7
<211> 136
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 beta chain variable
      domain with leader sequence

<400> 7
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr
            20                  25                  30
Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His
        35                  40                  45
Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu
65                  70                  75                  80
Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu
                85                  90                  95
Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Phe Ser Asp Gly Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro
        115                 120                 125
Gly Thr Arg Leu Thr Val Leu Glu
    130                 135

<210> 8
<211> 132
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta chain variable
      domain with leader sequence

<400> 8
Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly
 1               5                  10                  15
Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr
            20                  25                  30
Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met
        35                  40                  45
Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr
    50                  55                  60
Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp
65                  70                  75                  80
Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val
                85                  90                  95
Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg
            100                 105                 110
Pro His Ser Leu Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu
    130

<210> 9
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 alpha chain variable
      domain, leader sequence removed

<400> 9
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
 1               5                  10                  15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser
            20                  25                  30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
        35                  40                  45
Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
    50                  55                  60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65                  70                  75                  80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ile Gly Asn His
                85                  90                  95
Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn
            100                 105                 110

<210> 10
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 alpha chain variable
      domain, leader sequence removed

<400> 10
Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu Arg Leu Gln Glu Gly
 1               5                  10                  15
Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val Ser Gly Leu Arg Gly
            20                  25                  30
Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly Pro Glu Phe Leu Phe
        35                  40                  45
Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys Glu Arg Leu Lys Ala
    50                  55                  60
Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile Thr Ala Pro Lys Pro
65                  70                  75                  80
Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln Thr Met Asp Gly Asn
                85                  90                  95
Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro Asn
            100                 105                 110

<210> 11
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 alpha chain variable
      domain, leader sequence removed

<400> 11
Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala
 1               5                  10                  15
Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Ser Asp Tyr
            20                  25                  30
Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val
        35                  40                  45
Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe
    50                  55                  60
Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser
65                  70                  75                  80
Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys Ala Ser Ser Pro
                85                  90                  95
Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val Leu
            100                 105                 110
Ala Asn


<210> 12
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 alpha chain variable
      domain, leader sequence removed

<400> 12
Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala
 1               5                  10                  15
Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Ser Asn Tyr
            20                  25                  30
Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val
        35                  40                  45
Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe
    50                  55                  60
Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser
65                  70                  75                  80
Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Asn Pro
                85                  90                  95
Trp Glu Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu
            100                 105                 110
Ser Val Leu Pro Tyr
        115

<210> 13
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta chain variable
      domain, leader sequence removed

<400> 13
Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met Gly Met Thr
 1               5                  10                  15
Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His Arg Ala Met
            20                  25                  30
Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu Met Phe Val
        35                  40                  45
Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro Ser Arg Phe
    50                  55                  60
Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His Leu His Ala
65                  70                  75                  80
Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Gln Gly
                85                  90                  95
Thr Ser Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr
            100                 105                 110
Val Leu Glu
        115

<210> 14
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta chain variable
      domain, leader sequence removed

<400> 14
Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly
 1               5                  10                  15
Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met
            20                  25                  30
Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr
        35                  40                  45
Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr
    50                  55                  60
Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser
65                  70                  75                  80
Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser
                85                  90                  95
Leu Trp Asp Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
            100                 105                 110
Leu Val Leu Glu
        115

<210> 15
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 beta chain variable
      domain, leader sequence removed

<400> 15
Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly
 1               5                  10                  15
Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr
        35                  40                  45
Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg
    50                  55                  60
Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln
65                  70                  75                  80
Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Phe
                85                  90                  95
Ser Asp Gly Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg
            100                 105                 110
Leu Thr Val Leu Glu
        115

<210> 16
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta chain variable
      domain, leader sequence removed

<400> 16
Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly
 1               5                  10                  15
Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr
            20                  25                  30
Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala
        35                  40                  45
Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys
    50                  55                  60
Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr
65                  70                  75                  80
Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala
                85                  90                  95
Arg Pro His Ser Leu Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg
            100                 105                 110
Leu Thr Val Leu Glu
        115

<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 4 CDR1alpha

<400> 17
Asp Arg Gly Ser Gln Ser
 1               5

<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 4 CDR2alpha

<400> 18
Ile Tyr Ser Asn Gly Asp
 1               5

<210> 19
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 4 CDR3alpha

<400> 19
Cys Ala Val Asn Ile Gly Asn His Asp Met Arg Phe
 1               5                  10

<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 6 CDR1alpha

<400> 20
Val Ser Gly Leu Arg Gly
 1               5

<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 6 CDR2alpha

<400> 21
Leu Tyr Ser Ala Gly Glu Glu
 1               5

<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 6 CDR3alpha

<400> 22
Cys Ala Val Gln Thr Met Asp Gly Asn Gln Phe Tyr Phe
 1               5                  10

<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence  No. 7 CDR1alpha

<400> 23
Thr Ser Glu Ser Asp Tyr Tyr
 1               5

<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 CDR2alpha

<400> 24
Gln Glu Ala Tyr Lys Gln Gln Asn
 1               5

<210> 25
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 CDR3alpha

<400> 25
Cys Ala Ser Ser Pro Gly Thr Tyr Lys Tyr Ile Phe
 1               5                  10

<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 CDR1alpha

<400> 26
Thr Ser Glu Ser Asn Tyr Tyr
 1               5

<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 CDR2alpha

<400> 27
Gln Glu Ala Tyr Lys Gln Gln Asn
 1               5

<210> 28
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequenceNo. 10 CDR3alpha

<400> 28
Cys Ala Phe Asn Pro Trp Glu Asn Tyr Gly Gln Asn Phe Val Phe
 1               5                  10                  15

<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 CDR1beta

<400> 29
Met Gly His Arg Ala
 1               5

<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 CDR2beta

<400> 30
Tyr Ser Tyr Glu Lys Leu
 1               5

<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 CDR3beta

<400> 31
Cys Ala Ser Ser Gln Gly Thr Ser Gly Ala Asp Thr Gln Tyr Phe
 1               5                  10                  15

<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 CDR1beta

<400> 32
Met Asn His Glu Tyr
 1               5

<210> 33
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 CDR2beta

<400> 33
Ser Val Gly Ala Gly Ile
 1               5

<210> 34
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 CDR3beta

<400> 34
Cys Ala Ser Ser Tyr Ser Leu Trp Asp Leu Gln Glu Thr Gln Tyr Phe
 1               5                  10                  15

<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 CDR1beta

<400> 35
Ser Glu His Asn Arg
 1               5

<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 CDR2beta

<400> 36
Phe Gln Asn Glu Ala Gln
 1               5

<210> 37
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 CDR3beta

<400> 37
Cys Ala Ser Ser Phe Ser Asp Gly Gly Ala Thr Asp Thr Gln Tyr Phe
 1               5                  10                  15

<210> 38
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 CDR1beta

<400> 38
Asp Phe Gln Ala Thr Thr
 1               5

<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 CDR2beta

<400> 39
Ser Asn Glu Gly Ser Lys Ala
 1               5

<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 CDR3beta

<400> 40
Cys Ser Ala Arg Pro His Ser Leu Thr Asp Thr Gln Tyr Phe
 1               5                  10

<210> 41
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 TCR alpha constant domain

<400> 41
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 42
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 TCR alpha constant domain

<400> 42
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 43
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 TCR alpha constant domain

<400> 43
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 44
<211> 140
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 TCR alpha constant
      domain

<400> 44
Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser
 1               5                  10                  15
Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn
            20                  25                  30
Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val
        35                  40                  45
Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp
    50                  55                  60
Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile
65                  70                  75                  80
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
                85                  90                  95
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            100                 105                 110
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        115                 120                 125
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140

<210> 45
<211> 178
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR beta constant domain

<400> 45
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
 1               5                  10                  15
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
            20                  25                  30
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
        35                  40                  45
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
    50                  55                  60
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
65                  70                  75                  80
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
                85                  90                  95
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
            100                 105                 110
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
        115                 120                 125
Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala
    130                 135                 140
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
145                 150                 155                 160
Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser
                165                 170                 175
Arg Gly


<210> 46
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 alpha chain with leader
      sequence

<400> 46
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser
 1               5                  10                  15
Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu
            20                  25                  30
Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp
        35                  40                  45
Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser
    50                  55                  60
Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly
65                  70                  75                  80
Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu
                85                  90                  95
Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val
            100                 105                 110
Asn Ile Gly Asn His Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr
        115                 120                 125
Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 47
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 alpha chain with leader
      sequence

<400> 47
Met Glu Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu
 1               5                  10                  15
Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu
            20                  25                  30
Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val
        35                  40                  45
Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly
    50                  55                  60
Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys
65                  70                  75                  80
Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile
                85                  90                  95
Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln
            100                 105                 110
Thr Met Asp Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr
        115                 120                 125
Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg
    130                 135                 140
Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp
145                 150                 155                 160
Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr
                165                 170                 175
Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser
            180                 185                 190
Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe
        195                 200                 205
Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser
    210                 215                 220
Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn
225                 230                 235                 240
Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu
                245                 250                 255
Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 48
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 alpha chain with leader
      sequence

<400> 48
Met Ala Cys Pro Gly Phe Leu Trp Ala Leu Val Ile Ser Thr Cys Leu
 1               5                  10                  15
Glu Phe Ser Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
            20                  25                  30
Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Glu Ser Asp Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
    50                  55                  60
Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                85                  90                  95
Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys
            100                 105                 110
Ala Ser Ser Pro Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg
        115                 120                 125
Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln
    130                 135                 140
Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp
145                 150                 155                 160
Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr
                165                 170                 175
Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser
            180                 185                 190
Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn
        195                 200                 205
Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro
    210                 215                 220
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
225                 230                 235                 240
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu
                245                 250                 255
Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp
            260                 265                 270
Ser Ser


<210> 49
<211> 277
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 alpha chain with leader
      sequence

<400> 49
Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu
 1               5                  10                  15
Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser
            20                  25                  30
Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser
        35                  40                  45
Glu Ser Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln
    50                  55                  60
Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr
65                  70                  75                  80
Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser
                85                  90                  95
Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys
            100                 105                 110
Ala Phe Asn Pro Trp Glu Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro
        115                 120                 125
Gly Thr Arg Leu Ser Val Leu Pro Tyr Ile Gln Asn Pro Asp Pro Ala
    130                 135                 140
Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu
145                 150                 155                 160
Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser
                165                 170                 175
Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp
            180                 185                 190
Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala
        195                 200                 205
Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe
    210                 215                 220
Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe
225                 230                 235                 240
Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe
                245                 250                 255
Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu
            260                 265                 270
Arg Leu Trp Ser Ser
        275

<210> 50
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 alpha chain, leader
      sequence removed

<400> 50
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
 1               5                  10                  15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser
            20                  25                  30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
        35                  40                  45
Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
    50                  55                  60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65                  70                  75                  80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val Asn Ile Gly Asn His
                85                  90                  95
Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys Pro Asn Ile
            100                 105                 110
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
        115                 120                 125
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
    130                 135                 140
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu
145                 150                 155                 160
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
                165                 170                 175
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
            180                 185                 190
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys
        195                 200                 205
Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn
    210                 215                 220
Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe
225                 230                 235                 240
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
                245                 250

<210> 51
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 alpha chain, leader
      sequence removed

<400> 51
Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu Arg Leu Gln Glu Gly
 1               5                  10                  15
Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val Ser Gly Leu Arg Gly
            20                  25                  30
Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly Pro Glu Phe Leu Phe
        35                  40                  45
Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys Glu Arg Leu Lys Ala
    50                  55                  60
Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile Thr Ala Pro Lys Pro
65                  70                  75                  80
Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Gln Thr Met Asp Gly Asn
                85                  90                  95
Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro Asn Ile
            100                 105                 110
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
        115                 120                 125
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
    130                 135                 140
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu
145                 150                 155                 160
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
                165                 170                 175
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
            180                 185                 190
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys
        195                 200                 205
Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn
    210                 215                 220
Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe
225                 230                 235                 240
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
                245                 250

<210> 52
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 alpha chain, leader
      sequence removed

<400> 52
Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala
 1               5                  10                  15
Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Ser Asp Tyr
            20                  25                  30
Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val
        35                  40                  45
Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe
    50                  55                  60
Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser
65                  70                  75                  80
Asp Ser Gln Leu Gly Asp Ala Ala Met Tyr Phe Cys Ala Ser Ser Pro
                85                  90                  95
Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg Leu Lys Val Leu
            100                 105                 110
Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
        115                 120                 125
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
    130                 135                 140
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
145                 150                 155                 160
Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
                165                 170                 175
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
            180                 185                 190
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
        195                 200                 205
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
    210                 215                 220
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
225                 230                 235                 240
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
                245                 250

<210> 53
<211> 257
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 alpha chain, leader
      sequence removed

<400> 53
Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu Ala
 1               5                  10                  15
Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Ser Asn Tyr
            20                  25                  30
Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu Val
        35                  40                  45
Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg Phe
    50                  55                  60
Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile Ser
65                  70                  75                  80
Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Asn Pro
                85                  90                  95
Trp Glu Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu
            100                 105                 110
Ser Val Leu Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu
        115                 120                 125
Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe
    130                 135                 140
Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile
145                 150                 155                 160
Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn
                165                 170                 175
Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala
            180                 185                 190
Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu
        195                 200                 205
Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr
    210                 215                 220
Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu
225                 230                 235                 240
Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser
                245                 250                 255
Ser


<210> 54
<211> 312
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta chain with leader
      sequence

<400> 54
Met Gly Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Val Pro Ile Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met
            20                  25                  30
Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His
        35                  40                  45
Arg Ala Met Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu
    50                  55                  60
Met Phe Val Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro
65                  70                  75                  80
Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His
                85                  90                  95
Leu His Ala Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Gln Gly Thr Ser Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr
        115                 120                 125
Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val
    130                 135                 140
Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala
145                 150                 155                 160
Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu
                165                 170                 175
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp
            180                 185                 190
Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys
        195                 200                 205
Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg
    210                 215                 220
Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp
225                 230                 235                 240
Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala
                245                 250                 255
Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln
            260                 265                 270
Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys
        275                 280                 285
Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met
    290                 295                 300
Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 55
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta chain with leader
      sequence

<400> 55
Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala
 1               5                  10                  15
Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu
            20                  25                  30
Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His
        35                  40                  45
Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu
    50                  55                  60
Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro
65                  70                  75                  80
Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg
                85                  90                  95
Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser
            100                 105                 110
Ser Tyr Ser Leu Trp Asp Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly
        115                 120                 125
Thr Arg Leu Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu
    130                 135                 140
Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys
145                 150                 155                 160
Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu
                165                 170                 175
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr
            180                 185                 190
Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr
        195                 200                 205
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro
    210                 215                 220
Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn
225                 230                 235                 240
Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser
                245                 250                 255
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr
            260                 265                 270
Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly
        275                 280                 285
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala
    290                 295                 300
Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 56
<211> 314
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 beta chain with leader
      sequence

<400> 56
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala
 1               5                  10                  15
Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr
            20                  25                  30
Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His
        35                  40                  45
Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe
    50                  55                  60
Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu
65                  70                  75                  80
Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu
                85                  90                  95
Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala
            100                 105                 110
Ser Ser Phe Ser Asp Gly Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro
        115                 120                 125
Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro
    130                 135                 140
Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln
145                 150                 155                 160
Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val
                165                 170                 175
Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys
            180                 185                 190
Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg
        195                 200                 205
Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn
    210                 215                 220
Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu
225                 230                 235                 240
Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val
                245                 250                 255
Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser
            260                 265                 270
Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu
        275                 280                 285
Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met
    290                 295                 300
Ala Met Val Lys Arg Lys Asp Ser Arg Gly
305                 310

<210> 57
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta chain with leader
      sequence

<400> 57
Met Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly
 1               5                  10                  15
Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly Thr
            20                  25                  30
Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met
        35                  40                  45
Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr
    50                  55                  60
Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp
65                  70                  75                  80
Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val
                85                  90                  95
Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg
            100                 105                 110
Pro His Ser Leu Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 58
<211> 293
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta chain, leader
      sequence removed

<400> 58
Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met Gly Met Thr
 1               5                  10                  15
Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His Arg Ala Met
            20                  25                  30
Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu Met Phe Val
        35                  40                  45
Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro Ser Arg Phe
    50                  55                  60
Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His Leu His Ala
65                  70                  75                  80
Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Gln Gly
                85                  90                  95
Thr Ser Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr
            100                 105                 110
Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe
        115                 120                 125
Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val
    130                 135                 140
Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp
145                 150                 155                 160
Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro
                165                 170                 175
Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser
            180                 185                 190
Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe
        195                 200                 205
Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr
    210                 215                 220
Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp
225                 230                 235                 240
Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val
                245                 250                 255
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu
            260                 265                 270
Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg
        275                 280                 285
Lys Asp Ser Arg Gly
    290

<210> 59
<211> 294
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta chain, leader
      sequence removed

<400> 59
Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly
 1               5                  10                  15
Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met
            20                  25                  30
Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr
        35                  40                  45
Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr
    50                  55                  60
Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser
65                  70                  75                  80
Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser
                85                  90                  95
Leu Trp Asp Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu
            100                 105                 110
Leu Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
        115                 120                 125
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
    130                 135                 140
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
145                 150                 155                 160
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln
                165                 170                 175
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
            180                 185                 190
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
        195                 200                 205
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
    210                 215                 220
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
225                 230                 235                 240
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
                245                 250                 255
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
            260                 265                 270
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
        275                 280                 285
Arg Lys Asp Ser Arg Gly
    290

<210> 60
<211> 295
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 beta chain, leader
      sequence removed

<400> 60
Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly
 1               5                  10                  15
Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr
        35                  40                  45
Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg
    50                  55                  60
Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln
65                  70                  75                  80
Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Phe
                85                  90                  95
Ser Asp Gly Gly Ala Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg
            100                 105                 110
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
        115                 120                 125
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
    130                 135                 140
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
145                 150                 155                 160
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
                165                 170                 175
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
            180                 185                 190
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
        195                 200                 205
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
    210                 215                 220
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
225                 230                 235                 240
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
                245                 250                 255
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
            260                 265                 270
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
        275                 280                 285
Lys Arg Lys Asp Ser Arg Gly
    290                 295

<210> 61
<211> 295
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta chain, leader
      sequence removed

<400> 61
Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys Lys Ser Gly
 1               5                  10                  15
Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr
            20                  25                  30
Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala
        35                  40                  45
Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys
    50                  55                  60
Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr
65                  70                  75                  80
Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala
                85                  90                  95
Arg Pro His Ser Leu Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg
            100                 105                 110
Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala
        115                 120                 125
Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr
    130                 135                 140
Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser
145                 150                 155                 160
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro
                165                 170                 175
Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu
            180                 185                 190
Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn
        195                 200                 205
His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu
    210                 215                 220
Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu
225                 230                 235                 240
Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln
                245                 250                 255
Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala
            260                 265                 270
Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val
        275                 280                 285
Lys Arg Lys Asp Ser Arg Gly
    290                 295

<210> 62
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 alpha gene fragment

<400> 62
atgaaatcct tgagagtttt actagtgatc ctgtggcttc agttgagctg ggtttggagc      60
caacagaagg aggtggagca gaattctgga cccctcagtg ttccagaggg agccattgcc     120
tctctcaact gcacttacag tgaccgaggt tcccagtcct tcttctggta cagacaatat     180
tctgggaaaa gccctgagtt gataatgttc atatactcca atggtgacaa agaagatgga     240
aggtttacag cacagctcaa taaagccagc cagtatgttt ctctgctcat cagagactcc     300
cagcccagtg attcagccac ctacctctgt gccgtgaaca taggaaacca tgacatgcgc     360
tttggagcag ggaccagact gacagtaaaa ccaaatatcc agaaccctga ccctgccgtg     420
taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     480
tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     540
ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     600
gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     660
agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac     720
ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg     780
tttaatctgc tcatgacgct gcggctgtgg tccagctga                            819

<210> 63
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 alpha gene fragment

<400> 63
atggagaaaa tgttggagtg tgcattcata gtcttgtggc ttcagcttgg ctggttgagt      60
ggagaagacc aggtgacgca gagtcccgag gccctgagac tccaggaggg agagagtagc     120
agtctcaact gcagttacac agtcagcggt ttaagagggc tgttctggta taggcaagat     180
cctgggaaag gccctgaatt cctcttcacc ctgtattcag ctggggaaga aaaggagaaa     240
gaaaggctaa aagccacatt aacaaagaag gaaagctttc tgcacatcac agcccctaaa     300
cctgaagact cagccactta tctctgtgct gtgcagacca tggacggtaa ccagttctat     360
tttgggacag ggacaagttt gacggtcatt ccaaatatcc agaaccctga ccctgccgtg     420
taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     480
tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     540
ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     600
gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     660
agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac     720
ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg     780
tttaatctgc tcatgacgct gcggctgtgg tccagctga                            819

<210> 64
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 alpha gene fragment

<400> 64
atggcatgcc ctggcttcct gtgggcactt gtgatctcca cctgtcttga atttagcatg      60
gctcagacag tcactcagtc tcaaccagag atgtctgtgc aggaggcaga gaccgtgacc     120
ctgagctgca catatgacac cagtgagagt gattattatt tattctggta caagcagcct     180
cccagcaggc agatgattct cgttattcgc caagaagctt ataagcaaca gaatgcaaca     240
gagaatcgtt tctctgtgaa cttccagaaa gcagccaaat ccttcagtct caagatctca     300
gactcacagc tgggggatgc cgcgatgtat ttctgtgctt ccagtccagg aacctacaaa     360
tacatctttg gaacaggcac caggctgaag gttttagcaa atatccagaa ccctgaccct     420
gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat     480
tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa     540
actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac     600
aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc     660
ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat     720
acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg     780
gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                     825

<210> 65
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 alpha gene fragment

<400> 65
atgacacgag ttagcttgct gtgggcagtc gtggtctcca cctgtcttga atccggcatg      60
gcccagacag tcactcagtc tcaaccagag atgtctgtgc aggaggcaga gactgtgacc     120
ctgagttgca catatgacac cagtgagagt aattattatt tgttctggta caaacagcct     180
cccagcaggc agatgattct cgttattcgc caagaagctt ataagcaaca gaatgcaacg     240
gagaatcgtt tctctgtgaa cttccagaaa gcagccaaat ccttcagtct caagatctca     300
gactcacagc tgggggacac tgcgatgtat ttctgtgctt tcaacccttg ggagaactat     360
ggtcagaatt ttgtctttgg tcccggaacc agattgtccg tgctgcccta tatccagaac     420
cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta     480
ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc     540
acagacaaaa ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc     600
tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa     660
gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt     720
gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc     780
ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctga           834

<210> 66
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 alpha gene fragment,
      codon-optimized

<400> 66
atgaagagcc tgagagtcct gctggtgatt ttgtggctgc agctgtcttg ggtttggtct      60
cagcagaaag aagtggagca gaatagcggc cctctgtctg ttcctgaagg cgctattgct     120
agcctgaatt gcacatacag cgatagagga tctcagagct tcttctggta ccggcagtac     180
agcggcaaga gcccagaact gatcatgttc atctacagca atggcgacaa ggaggatggc     240
aggtttacag cccagctgaa caaggccagc cagtatgttt ctctgctgat cagagatagc     300
cagcctagcg attctgccac ctacctgtgt gccgtgaaca tcggaaatca cgacatgaga     360
tttggagccg gcacaagact gaccgtgaag cccaatatcc agaaccctga tcctgctgtg     420
taccagctgc gggacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac     480
agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg     540
ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc     600
gacttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca     660
agccccgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac     720
ctgaacttcc agaacctcag cgtgatcggc ttccggatcc tgctgctgaa ggtggccggc     780
ttcaacctgc tgatgaccct gcggctgtgg tccagctga                            819

<210> 67
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 alpha gene fragment,
      codon-optimized

<400> 67
atggagaaga tgctggagtg tgcgttcatc gttctgtggc tgcaacttgg atggctgtct      60
ggagaggatc aggttacaca gtctcctgaa gccctgagac tgcaagaagg agaaagctct     120
agcctgaact gcagctacac agtgtctgga ctgagaggcc tgttctggta cagacaggat     180
cctggaaaag gcccagagtt cctgtttacc ctgtattctg ccggcgagga gaaggagaaa     240
gagagactga aagctaccct gaccaagaag gagagcttcc tgcacattac cgcccccaaa     300
cctgaggatt ctgccacata tctgtgtgct gtgcagacca tggatggcaa ccagttctac     360
ttcggcacag gcacatctct gaccgttatc cccaatatcc agaaccctga tcctgccgtg     420
taccagctgc gggacagcaa gagcagcgac aagagcgtgt gcctgttcac cgacttcgac     480
agccagacca acgtgtccca gagcaaggac agcgacgtgt acatcaccga taagtgcgtg     540
ctggacatgc ggagcatgga cttcaagagc aacagcgccg tggcctggtc caacaagagc     600
gacttcgcct gcgccaacgc cttcaacaac agcattatcc ccgaggacac attcttccca     660
agccccgaga gcagctgcga cgtgaagctg gtggaaaaga gcttcgagac agacaccaac     720
ctgaacttcc agaacctcag cgtgatcggc ttccggatcc tgctgctgaa ggtggccggc     780
ttcaacctgc tgatgaccct gcggctgtgg tccagctga                            819

<210> 68
<211> 825
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 alpha gene fragment,
      codon-optimized

<400> 68
atggcttgtc ctggattctt atgggctctg gtgatcagca cctgtctgga gttctctatg      60
gcccagacag tgacacagtc tcagcctgaa atgtctgtgc aggaagccga aaccgtgaca     120
ctgtcttgca cctacgatac aagcgagagc gactactacc tgttctggta caagcagcct     180
ccctctaggc agatgatcct ggtgattaga caggaggcct acaaacagca gaatgccacc     240
gagaaccggt ttagcgtgaa cttccagaaa gccgccaaga gcttcagcct gaaaatctct     300
gacagccagc tgggagatgc tgccatgtac ttttgtgcca gctctccagg cacctacaag     360
tacatttttg gcaccggcac cagactgaag gtgctggcca atatccagaa tcccgatcct     420
gccgtgtacc agctgcggga cagcaagagc agcgacaaga gcgtgtgcct gttcaccgac     480
ttcgacagcc agaccaacgt gtcccagagc aaggacagcg acgtgtacat caccgataag     540
tgcgtgctgg acatgcggag catggacttc aagagcaaca gcgccgtggc ctggtccaac     600
aagagcgact tcgcctgcgc caacgccttc aacaacagca ttatccccga ggacacattc     660
ttcccaagcc ccgagagcag ctgcgacgtg aagctggtgg aaaagagctt cgagacagac     720
accaacctga acttccagaa cctcagcgtg atcggcttcc ggatcctgct gctgaaggtg     780
gccggcttca acctgctgat gaccctgcgg ctgtggtcca gctga                     825

<210> 69
<211> 834
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 alpha gene fragment,
      codon-optimized

<400> 69
atgaccagag ttagcctgtt atgggctgtg gtggtgagca catgtctgga atctggaatg      60
gcccagacag tgacacagtc tcagcctgaa atgtctgtgc aggaagccga aaccgttaca     120
ctgagctgca cctacgatac aagcgagagc aactactacc tgttctggta caagcagccc     180
ccttctaggc agatgatcct ggtgatcaga caggaggcct ataaacagca gaatgccacc     240
gagaaccggt ttagcgtgaa cttccagaaa gccgccaaga gcttcagcct gaaaatctct     300
gacagccagc tgggcgatac agccatgtac ttttgtgcct tcaacccctg ggagaactat     360
ggccagaatt tcgtgttcgg ccctggcacc agactgtctg ttctgcctta tatccagaac     420
cccgatcctg ctgtgtacca gctgcgggac agcaagagca gcgacaagag cgtgtgcctg     480
ttcaccgact tcgacagcca gaccaacgtg tcccagagca aggacagcga cgtgtacatc     540
accgataagt gcgtgctgga catgcggagc atggacttca agagcaacag cgccgtggcc     600
tggtccaaca agagcgactt cgcctgcgcc aacgccttca acaacagcat tatccccgag     660
gacacattct tcccaagccc cgagagcagc tgcgacgtga agctggtgga aaagagcttc     720
gagacagaca ccaacctgaa cttccagaac ctcagcgtga tcggcttccg gatcctgctg     780
ctgaaggtgg ccggcttcaa cctgctgatg accctgcggc tgtggtccag ctga           834

<210> 70
<211> 939
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta gene fragment

<400> 70
atgggctgca ggctgctctg ctgtgcggtt ctctgtctcc tgggagcagt tcccatagac      60
actgaagtta cccagacacc aaaacacctg gtcatgggaa tgacaaataa gaagtctttg     120
aaatgtgaac aacatatggg gcacagggct atgtattggt acaagcagaa agctaagaag     180
ccaccggagc tcatgtttgt ctacagctat gagaaactct ctataaatga aagtgtgcca     240
agtcgcttct cacctgaatg ccccaacagc tctctcttaa accttcacct acacgccctg     300
cagccagaag actcagccct gtatctctgc gccagcagcc aagggactag cggggcagat     360
acgcagtatt ttggcccagg cacccggctg acagtgctcg aggacctgaa aaacgtgttc     420
ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc     480
acactggtgt gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg     540
aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc     600
gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg     660
cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac     720
gagtggaccc aggatagggc caaacctgtc acccagatcg tcagcgccga ggcctggggt     780
agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc     840
ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg     900
ctgatggcca tggtcaagag aaaggattcc agaggctag                            939

<210> 71
<211> 942
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta gene fragment

<400> 71
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat      60
gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg     120
cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg     180
gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc     240
aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct     300
gctccctccc agacatctgt gtacttctgt gccagcagtt actctctttg ggaccttcaa     360
gagacccagt acttcgggcc aggcacgcgg ctcctggtgc tcgaggacct gaaaaacgtg     420
ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     480
gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg     540
gtgaatggga aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag     600
cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     660
tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     720
gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg     780
ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc     840
atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc     900
gtgctgatgg ccatggtcaa gagaaaggat tccagaggct ag                        942

<210> 72
<211> 945
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 beta gene fragment

<400> 72
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat      60
actggagtct cccaggaccc cagacacaag atcacaaaga ggggacagaa tgtaactttc     120
aggtgtgatc caatttctga acacaaccgc ctttattggt accgacagac cctggggcag     180
ggcccagagt ttctgactta cttccagaat gaagctcaac tagaaaaatc aaggctgctc     240
agtgatcggt tctctgcaga gaggcctaag ggatctttct ccaccttgga gatccagcgc     300
acagagcagg gggactcggc catgtatctc tgtgccagca gcttttcaga cgggggggct     360
acagatacgc agtattttgg cccaggcacc cggctgacag tgctcgagga cctgaaaaac     420
gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag cagagatctc ccacacccaa     480
aaggccacac tggtgtgcct ggccacaggc ttctaccccg accacgtgga gctgagctgg     540
tgggtgaatg ggaaggaggt gcacagtggg gtcagcacag acccgcagcc cctcaaggag     600
cagcccgccc tcaatgactc cagatactgc ctgagcagcc gcctgagggt ctcggccacc     660
ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc agttctacgg gctctcggag     720
aatgacgagt ggacccagga tagggccaaa cctgtcaccc agatcgtcag cgccgaggcc     780
tggggtagag cagactgtgg cttcacctcc gagtcttacc agcaaggggt cctgtctgcc     840
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc     900
ctcgtgctga tggccatggt caagagaaag gattccagag gctag                     945

<210> 73
<211> 933
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta gene fragment

<400> 73
atgctgctgc ttctgctgct tctggggcca gcaggctccg ggcttggtgc tgtcgtctct      60
caacatccga gctgggttat ctgtaagagt ggaacctctg tgaagatcga gtgccgttcc     120
ctggactttc aggccacaac tatgttttgg tatcgtcagt tcccgaaaca gagtctcatg     180
ctgatggcaa cttccaatga gggctccaag gccacatacg agcaaggcgt cgagaaggac     240
aagtttctca tcaaccatgc aagcctgacc ttgtccactc tgacagtgac cagtgcccat     300
cctgaagaca gcagcttcta catctgcagt gctagacccc attctctcac agatacgcag     360
tattttggcc caggcacccg gctgacagtg ctcgaggacc tgaaaaacgt gttcccaccc     420
gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     480
gtgtgcctgg ccacaggctt ctaccccgac cacgtggagc tgagctggtg ggtgaatggg     540
aaggaggtgc acagtggggt cagcacagac ccgcagcccc tcaaggagca gcccgccctc     600
aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     660
ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     720
acccaggata gggccaaacc tgtcacccag atcgtcagcg ccgaggcctg gggtagagca     780
gactgtggct tcacctccga gtcttaccag caaggggtcc tgtctgccac catcctctat     840
gagatcttgc tagggaaggc caccttgtat gccgtgctgg tcagtgccct cgtgctgatg     900
gccatggtca agagaaagga ttccagaggc tag                                  933

<210> 74
<211> 936
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta gene fragment,
      codon-optimized

<400> 74
atgggctgta gactgttgtg ttgtgctgtg ctgtgtctgt tgggagctgt gcctatcgat      60
acagaggtga cccagacccc taaacatctg gttatgggca tgaccaacaa gaagagcctg     120
aagtgcgagc agcacatggg ccatagggcc atgtattggt ataagcagaa ggccaagaaa     180
cctcctgagc tgatgttcgt gtacagctac gagaagctga gcatcaacga gagcgtgccc     240
agcagatttt ctcctgagtg ccctaattct agcctgctga atctgcacct gcatgctctg     300
cagcctgagg attctgctct gtacctgtgt gcttcttctc agggcacatc tggagctgat     360
acacagtact tcggacctgg cacaagactg acagtgctgg aagacctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggc                               936

<210> 75
<211> 939
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta gene fragment,
      codon-optimized

<400> 75
atgtctatcg gtctgctgtg ctgtgctgct ctttctctgc tttgggctgg acctgtgaat      60
gctggagtta cacaaacccc caagttccaa gtgctgaaga caggacagag catgaccctg     120
cagtgtgctc aggacatgaa tcacgagtac atgagctggt acagacagga tcctggaatg     180
ggcctgaggc tgatccacta ctctgttgga gccggaatta cagatcaggg agaagtgcca     240
aatggctaca acgtgagcag gagcacaacc gaggacttcc ccttaagact gttgtctgct     300
gctccatctc agacaagcgt gtacttttgc gccagctcct actctctgtg ggatctgcag     360
gaaacccagt actttggacc aggcacaaga ctgttagtgc tggaggacct gaagaacgtg     420
ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa     480
gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag     600
cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg     780
ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc     840
atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg     900
gtgctgatgg ccatggtcaa gcggaaggac agccggggc                            939

<210> 76
<211> 942
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 7 beta gene fragment,
      codon-optimized

<400> 76
atgggcacat ctcttctctg ctggatggct ctttgtctgc ttggagccga tcatgccgat      60
acaggagtta gccaggatcc tagacacaag atcaccaaga gaggccagaa tgtgaccttc     120
cggtgcgatc ctatctctga gcacaacagg ctgtactggt acagacaaac actgggacaa     180
ggacctgagt tcctgaccta cttccagaac gaagcccagc tggagaagtc tagacttctg     240
agcgacagat ttagcgccga gagacctaaa ggcagcttta gcaccctgga gatccagaga     300
acagaacagg gcgattctgc catgtacctg tgtgctagca gcttttctga tggaggcgcc     360
accgatacac agtatttcgg acctggcaca agactgacag tgctggagga cctgaagaac     420
gtgttccccc cagaggtggc cgtgttcgag cctagcgagg ccgagatcag ccacacccag     480
aaagccaccc tcgtgtgcct ggccaccggc ttttaccccg accacgtgga actgtcttgg     540
tgggtcaacg gcaaagaggt gcacagcggc gtctgcaccg acccccagcc cctgaaagag     600
cagcccgccc tgaacgacag ccggtactgt ctgagcagca gactgagagt gtccgccacc     660
ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttctacgg cctgagcgag     720
aacgacgagt ggacccagga ccgggccaag cccgtgaccc agatcgtgtc tgctgaggcc     780
tggggcagag ccgattgcgg cttcaccagc gagagctacc agcagggcgt gctgagcgcc     840
accatcctgt acgagatcct gctgggcaag gccaccctgt acgccgtgct ggtgtccgcc     900
ctggtgctga tggccatggt caagcggaag gacagccggg gc                        942

<210> 77
<211> 930
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta gene fragment,
      codon-optimized

<400> 77
atgctgcttc ttctcctcct tctcggacct gctggatctg gattaggagc tgttgtgtct      60
cagcaccctt cttgggtgat ctgtaaaagc ggcacaagcg tgaagatcga gtgcagaagc     120
ctggactttc aggccacaac catgttctgg tataggcagt tccccaagca gtctctgatg     180
ctgatggcca cctctaatga gggctctaag gccacatatg aacagggagt ggagaaggac     240
aagttcctga tcaaccacgc ctctctgacc ctgtctaccc tgacagttac atctgcccac     300
cctgaggata gcagctttta catctgtagc gccagacctc acagcctgac cgatacacag     360
tactttggcc ctggcacaag actgacagtg ttagaagacc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc                                      930

<210> 78
<211> 1821
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 4 beta-P2A-No. 4 alpha,
      codon-optimized

<400> 78
atgggctgta gactgttgtg ttgtgctgtg ctgtgtctgt tgggagctgt gcctatcgat      60
acagaggtga cccagacccc taaacatctg gttatgggca tgaccaacaa gaagagcctg     120
aagtgcgagc agcacatggg ccatagggcc atgtattggt ataagcagaa ggccaagaaa     180
cctcctgagc tgatgttcgt gtacagctac gagaagctga gcatcaacga gagcgtgccc     240
agcagatttt ctcctgagtg ccctaattct agcctgctga atctgcacct gcatgctctg     300
cagcctgagg attctgctct gtacctgtgt gcttcttctc agggcacatc tggagctgat     360
acacagtact tcggacctgg cacaagactg acagtgctgg aagacctgaa gaacgtgttc     420
cccccagagg tggccgtgtt cgagcctagc gaggccgaga tcagccacac ccagaaagcc     480
accctcgtgt gcctggccac cggcttttac cccgaccacg tggaactgtc ttggtgggtc     540
aacggcaaag aggtgcacag cggcgtctgc accgaccccc agcccctgaa agagcagccc     600
gccctgaacg acagccggta ctgtctgagc agcagactga gagtgtccgc caccttctgg     660
cagaaccccc ggaaccactt cagatgccag gtgcagttct acggcctgag cgagaacgac     720
gagtggaccc aggaccgggc caagcccgtg acccagatcg tgtctgctga ggcctggggc     780
agagccgatt gcggcttcac cagcgagagc taccagcagg gcgtgctgag cgccaccatc     840
ctgtacgaga tcctgctggg caaggccacc ctgtacgccg tgctggtgtc cgccctggtg     900
ctgatggcca tggtcaagcg gaaggacagc cggggcggtt ccggagccac gaacttctct     960
ctgttaaagc aagcaggaga cgtggaagaa aaccccggtc ccatgaagag cctgagagtc    1020
ctgctggtga ttttgtggct gcagctgtct tgggtttggt ctcagcagaa agaagtggag    1080
cagaatagcg gccctctgtc tgttcctgaa ggcgctattg ctagcctgaa ttgcacatac    1140
agcgatagag gatctcagag cttcttctgg taccggcagt acagcggcaa gagcccagaa    1200
ctgatcatgt tcatctacag caatggcgac aaggaggatg gcaggtttac agcccagctg    1260
aacaaggcca gccagtatgt ttctctgctg atcagagata gccagcctag cgattctgcc    1320
acctacctgt gtgccgtgaa catcggaaat cacgacatga gatttggagc cggcacaaga    1380
ctgaccgtga agcccaatat ccagaaccct gatcctgctg tgtaccagct gcgggacagc    1440
aagagcagcg acaagagcgt gtgcctgttc accgacttcg acagccagac caacgtgtcc    1500
cagagcaagg acagcgacgt gtacatcacc gataagtgcg tgctggacat gcggagcatg    1560
gacttcaaga gcaacagcgc cgtggcctgg tccaacaaga gcgacttcgc ctgcgccaac    1620
gccttcaaca acagcattat ccccgaggac acattcttcc caagccccga gagcagctgc    1680
gacgtgaagc tggtggaaaa gagcttcgag acagacacca acctgaactt ccagaacctc    1740
agcgtgatcg gcttccggat cctgctgctg aaggtggccg gcttcaacct gctgatgacc    1800
ctgcggctgt ggtccagctg a                                              1821

<210> 79
<211> 1824
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 6 beta-P2A-No. 6 alpha,
      codon-optimized

<400> 79
atgtctatcg gtctgctgtg ctgtgctgct ctttctctgc tttgggctgg acctgtgaat      60
gctggagtta cacaaacccc caagttccaa gtgctgaaga caggacagag catgaccctg     120
cagtgtgctc aggacatgaa tcacgagtac atgagctggt acagacagga tcctggaatg     180
ggcctgaggc tgatccacta ctctgttgga gccggaatta cagatcaggg agaagtgcca     240
aatggctaca acgtgagcag gagcacaacc gaggacttcc ccttaagact gttgtctgct     300
gctccatctc agacaagcgt gtacttttgc gccagctcct actctctgtg ggatctgcag     360
gaaacccagt actttggacc aggcacaaga ctgttagtgc tggaggacct gaagaacgtg     420
ttccccccag aggtggccgt gttcgagcct agcgaggccg agatcagcca cacccagaaa     480
gccaccctcg tgtgcctggc caccggcttt taccccgacc acgtggaact gtcttggtgg     540
gtcaacggca aagaggtgca cagcggcgtc tgcaccgacc cccagcccct gaaagagcag     600
cccgccctga acgacagccg gtactgtctg agcagcagac tgagagtgtc cgccaccttc     660
tggcagaacc cccggaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac     720
gacgagtgga cccaggaccg ggccaagccc gtgacccaga tcgtgtctgc tgaggcctgg     780
ggcagagccg attgcggctt caccagcgag agctaccagc agggcgtgct gagcgccacc     840
atcctgtacg agatcctgct gggcaaggcc accctgtacg ccgtgctggt gtccgccctg     900
gtgctgatgg ccatggtcaa gcggaaggac agccggggcg gttccggagc cacgaacttc     960
tctctgttaa agcaagcagg agacgtggaa gaaaaccccg gtcccatgga gaagatgctg    1020
gagtgtgcgt tcatcgttct gtggctgcaa cttggatggc tgtctggaga ggatcaggtt    1080
acacagtctc ctgaagccct gagactgcaa gaaggagaaa gctctagcct gaactgcagc    1140
tacacagtgt ctggactgag aggcctgttc tggtacagac aggatcctgg aaaaggccca    1200
gagttcctgt ttaccctgta ttctgccggc gaggagaagg agaaagagag actgaaagct    1260
accctgacca agaaggagag cttcctgcac attaccgccc ccaaacctga ggattctgcc    1320
acatatctgt gtgctgtgca gaccatggat ggcaaccagt tctacttcgg cacaggcaca    1380
tctctgaccg ttatccccaa tatccagaac cctgatcctg ccgtgtacca gctgcgggac    1440
agcaagagca gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg    1500
tcccagagca aggacagcga cgtgtacatc accgataagt gcgtgctgga catgcggagc    1560
atggacttca agagcaacag cgccgtggcc tggtccaaca agagcgactt cgcctgcgcc    1620
aacgccttca acaacagcat tatccccgag gacacattct tcccaagccc cgagagcagc    1680
tgcgacgtga agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac    1740
ctcagcgtga tcggcttccg gatcctgctg ctgaaggtgg ccggcttcaa cctgctgatg    1800
accctgcggc tgtggtccag ctga                                           1824

<210> 80

<400> 80
 000

<210> 81
<211> 1830
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence No. 10 beta-P2A-No. 10 alpha,
      codon-optimized

<400> 81
atgctgcttc ttctcctcct tctcggacct gctggatctg gattaggagc tgttgtgtct      60
cagcaccctt cttgggtgat ctgtaaaagc ggcacaagcg tgaagatcga gtgcagaagc     120
ctggactttc aggccacaac catgttctgg tataggcagt tccccaagca gtctctgatg     180
ctgatggcca cctctaatga gggctctaag gccacatatg aacagggagt ggagaaggac     240
aagttcctga tcaaccacgc ctctctgacc ctgtctaccc tgacagttac atctgcccac     300
cctgaggata gcagctttta catctgtagc gccagacctc acagcctgac cgatacacag     360
tactttggcc ctggcacaag actgacagtg ttagaagacc tgaagaacgt gttcccccca     420
gaggtggccg tgttcgagcc tagcgaggcc gagatcagcc acacccagaa agccaccctc     480
gtgtgcctgg ccaccggctt ttaccccgac cacgtggaac tgtcttggtg ggtcaacggc     540
aaagaggtgc acagcggcgt ctgcaccgac ccccagcccc tgaaagagca gcccgccctg     600
aacgacagcc ggtactgtct gagcagcaga ctgagagtgt ccgccacctt ctggcagaac     660
ccccggaacc acttcagatg ccaggtgcag ttctacggcc tgagcgagaa cgacgagtgg     720
acccaggacc gggccaagcc cgtgacccag atcgtgtctg ctgaggcctg gggcagagcc     780
gattgcggct tcaccagcga gagctaccag cagggcgtgc tgagcgccac catcctgtac     840
gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtccgccct ggtgctgatg     900
gccatggtca agcggaagga cagccggggc ggttccggag ccacgaactt ctctctgtta     960
aagcaagcag gagacgtgga agaaaacccc ggtcccatga ccagagttag cctgttatgg    1020
gctgtggtgg tgagcacatg tctggaatct ggaatggccc agacagtgac acagtctcag    1080
cctgaaatgt ctgtgcagga agccgaaacc gttacactga gctgcaccta cgatacaagc    1140
gagagcaact actacctgtt ctggtacaag cagccccctt ctaggcagat gatcctggtg    1200
atcagacagg aggcctataa acagcagaat gccaccgaga accggtttag cgtgaacttc    1260
cagaaagccg ccaagagctt cagcctgaaa atctctgaca gccagctggg cgatacagcc    1320
atgtactttt gtgccttcaa cccctgggag aactatggcc agaatttcgt gttcggccct    1380
ggcaccagac tgtctgttct gccttatatc cagaaccccg atcctgctgt gtaccagctg    1440
cgggacagca agagcagcga caagagcgtg tgcctgttca ccgacttcga cagccagacc    1500
aacgtgtccc agagcaagga cagcgacgtg tacatcaccg ataagtgcgt gctggacatg    1560
cggagcatgg acttcaagag caacagcgcc gtggcctggt ccaacaagag cgacttcgcc    1620
tgcgccaacg ccttcaacaa cagcattatc cccgaggaca cattcttccc aagccccgag    1680
agcagctgcg acgtgaagct ggtggaaaag agcttcgaga cagacaccaa cctgaacttc    1740
cagaacctca gcgtgatcgg cttccggatc ctgctgctga aggtggccgg cttcaacctg    1800
ctgatgaccc tgcggctgtg gtccagctga                                     1830

<210> 82
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Reference TCR alpha chain

<400> 82
Met Thr Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp
 1               5                  10                  15
Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val
            20                  25                  30
Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala
        35                  40                  45
Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Arg Pro Gln
    50                  55                  60
Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg
65                  70                  75                  80
Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile
                85                  90                  95
Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Thr
            100                 105                 110
Glu Asp Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys
        115                 120                 125
Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
    130                 135                 140
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
145                 150                 155                 160
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
                165                 170                 175
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
            180                 185                 190
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
        195                 200                 205
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
    210                 215                 220
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
225                 230                 235                 240
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
                245                 250                 255
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
            260                 265                 270

<210> 83
<211> 310
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Reference TCR beta chain

<400> 83
Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala
 1               5                  10                  15
Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg
            20                  25                  30
Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His
        35                  40                  45
Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu
    50                  55                  60
Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala
65                  70                  75                  80
Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr
                85                  90                  95
Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser
            100                 105                 110
Ser Pro Gly Ala Leu Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu
        115                 120                 125
Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val
    130                 135                 140
Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu
145                 150                 155                 160
Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp
                165                 170                 175
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln
            180                 185                 190
Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser
        195                 200                 205
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His
    210                 215                 220
Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp
225                 230                 235                 240
Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala
                245                 250                 255
Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly
            260                 265                 270
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr
        275                 280                 285
Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys
    290                 295                 300
Arg Lys Asp Ser Arg Gly
305                 310

<210> 84
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-1 2A
      (P2A-1) peptide

<400> 84
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
 1               5                  10                  15
Glu Glu Asn Pro Gly Pro
            20

<210> 85
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-2 2A
      (P2A-2) peptide

<400> 85
Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 86
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Thosea asigna virus 2A (T2A)
      peptide

<400> 86
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
 1               5                  10                  15
Glu Asn Pro Gly Pro
            20

<210> 87
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Equine rhinitis A virus (ERAV)
      2A (E2A) peptide

<400> 87
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp
 1               5                  10                  15
Val Glu Ser Asn Pro Gly Pro
            20

<210> 88
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Foot-and-mouth disease virus 2A
      (F2A) peptide

<400> 88
Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala
 1               5                  10                  15
Gly Asp Val Glu Ser Asn Pro Gly Pro
            20                  25

<210> 89
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-1 2A
      (P2A-1) peptide - nt sequence

<400> 89
ggaagtggag ctacgaattt ttctttatta aaacaagcag gagatgttga ggagaatccc      60
ggtcca                                                                 66

<210> 90
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Porcine teschovirus-2 2A
      (P2A-2) peptide - nt sequence

<400> 90
agcggcgcca ccaacttcag cctgctgaaa caggccggcg acgtggaaga gaaccctggc      60
cct                                                                    63

<210> 91
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Thosea asigna virus 2A (T2A)
      peptide - nt sequence

<400> 91
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga      60
cct                                                                    63

<210> 92
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Equine rhinitis A virus (ERAV)
      2A (E2A) peptide - nt sequence

<400> 92
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac      60
cctggacct                                                              69

<210> 93
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Foot-and-mouth disease virus 2A
      (F2A) peptide - nt sequence

<400> 93
ggaagcggag tgaaacagac tttgaatttt gaccttctca agttggcggg agacgtggag      60
tccaaccctg gacct                                                       75

<210> 94
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence WT-1 peptide antigen

<400> 94
Arg Met Phe Pro Asn Ala Pro Tyr Leu
 1               5

<210> 95
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence G-S linker

<400> 95
Gly Gly Gly Gly Ser
 1               5

<210> 96
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence G-S linker

<400> 96
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser
 1               5                  10                  15
Ser Ser Ser Ser
            20

<210> 97
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence meganuclease recognition site

<400> 97
Leu Ala Gly Leu Ile Asp Ala Asp Gly
 1               5

<210> 98
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence meganuclease recognition site

<400> 98
Gly Ile Tyr Tyr Ile Gly
 1               5

<210> 99
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence meganuclease recognition site

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Asp or Glu

<220>
<221> VARIANT        
<222> 4
<223> Xaa = any amino acid

<400> 99
Pro Asp Xaa Xaa Lys
 1               5

<210> 100
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence WT-1 aa 37-45

<400> 100
Val Leu Asp Phe Ala Pro Pro Gly Ala
 1               5

<210> 101
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 CDR1alpha

<400> 101
Asp Ser Ala Ile Tyr Asn
 1               5

<210> 102
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TTCR 10.1 CDR2alpha

<400> 102
Ile Gln Ser Ser Gln Arg Glu
 1               5

<210> 103
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 CDR3alpha

<400> 103
Cys Ala Val Lys Glu Thr Ser Gly Ser Arg Leu Thr Phe
 1               5                  10

<210> 104
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 Valpha

<400> 104
Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly
 1               5                  10                  15
Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn
            20                  25                  30
Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu
        35                  40                  45
Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala
    50                  55                  60
Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser
65                  70                  75                  80
Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Lys Glu Thr Ser
                85                  90                  95
Gly Ser Arg Leu Thr Phe Gly Glu Gly Thr Gln Leu Thr Val Asn Pro
            100                 105                 110

<210> 105
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 CDR1beta

<400> 105
Ser Gly His Val Ser
 1               5

<210> 106
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 CDR2beta

<400> 106
Phe Asn Tyr Glu Ala Gln
 1               5

<210> 107
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 CDR3beta

<400> 107
Cys Ala Ser Ser Leu Thr Gly Ser Tyr Glu Gln Tyr Phe
 1               5                  10

<210> 108
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 10.1 Vbeta

<400> 108
Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr Lys Arg Gly
 1               5                  10                  15
Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His Val Ser Leu
            20                  25                  30
Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr
        35                  40                  45
Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro Asn Asp Arg
    50                  55                  60
Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu Thr Ile Gln
65                  70                  75                  80
Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala Ser Ser Leu
                85                  90                  95
Thr Gly Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val
            100                 105                 110
Thr Glu


<210> 109
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 CDR1alpha

<400> 109
Asn Ser Met Phe Asp Tyr
 1               5

<210> 110
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 CDR2alpha

<400> 110
Ile Ser Ser Ile Lys Asp Lys
 1               5

<210> 111
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 CDR3alpha

<400> 111
Cys Ala Ala Ser Gly Ile Gly Asp Tyr Lys Leu Ser Phe
 1               5                  10

<210> 112
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 Valpha

<400> 112
Asp Gln Gln Val Lys Gln Asn Ser Pro Ser Leu Ser Val Gln Glu Gly
 1               5                  10                  15
Arg Ile Ser Ile Leu Asn Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr
            20                  25                  30
Phe Leu Trp Tyr Lys Lys Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile
        35                  40                  45
Ser Ile Ser Ser Ile Lys Asp Lys Asn Glu Asp Gly Arg Phe Thr Val
    50                  55                  60
Phe Leu Asn Lys Ser Ala Lys His Leu Ser Leu His Ile Val Pro Ser
65                  70                  75                  80
Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser Gly Ile Gly
                85                  90                  95
Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala
            100                 105                 110
Asn


<210> 113
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 CDR1beta

<400> 113
Pro Arg His Asp Thr
 1               5

<210> 114
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 CDR2beta

<400> 114
Phe Tyr Glu Lys Met Gln
 1               5

<210> 115
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 CDR3beta

<400> 115
Cys Ala Ser Ser Leu Arg Leu Gly Arg Glu Thr Gln Tyr Phe
 1               5                  10

<210> 116
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 13.1 Vbeta

<400> 116
Ala Ala Gly Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg
 1               5                  10                  15
Glu Thr Ala Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val
            20                  25                  30
Tyr Trp Tyr Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser
        35                  40                  45
Phe Tyr Glu Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe
    50                  55                  60
Ser Ala Gln Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser
65                  70                  75                  80
Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Arg
                85                  90                  95
Leu Gly Arg Glu Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val
            100                 105                 110
Leu Glu


<210> 117
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 CDR1alpha

<400> 117
Val Ser Gly Leu Arg Gly
 1               5

<210> 118
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 CDR2alpha

<400> 118
Leu Tyr Ser Ala Gly Glu Glu
 1               5

<210> 119
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 CDR3alpha

<400> 119
Cys Ala Val Ile Thr Gly Phe Gln Lys Leu Val Phe
 1               5                  10

<210> 120
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 Valpha

<400> 120
Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu Arg Leu Gln Glu Gly
 1               5                  10                  15
Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val Ser Gly Leu Arg Gly
            20                  25                  30
Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly Pro Glu Phe Leu Phe
        35                  40                  45
Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys Glu Arg Leu Lys Ala
    50                  55                  60
Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile Thr Ala Pro Lys Pro
65                  70                  75                  80
Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Ile Thr Gly Phe Gln Lys
                85                  90                  95
Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val Ser Pro Asn
            100                 105                 110

<210> 121
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 CDR1beta

<400> 121
Met Asn His Glu Tyr
 1               5

<210> 122
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 CDR2beta

<400> 122
Ser Met Asn Val Glu Val
 1               5

<210> 123
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 CDR3beta

<400> 123
Cys Ala Ser Ser Phe Ser Gly Gly Thr Tyr Glu Gln Tyr Phe
 1               5                  10

<210> 124
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence TCR 16.1 Vbeta

<400> 124
Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly
 1               5                  10                  15
Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met
            20                  25                  30
Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr
        35                  40                  45
Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr
    50                  55                  60
Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser
65                  70                  75                  80
Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Phe Ser
                85                  90                  95
Gly Gly Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val
            100                 105                 110
Thr Glu

