                               SEQUENCE LISTING

<110> THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF 
      MILITARY MEDICINE, INC.
      BATTELLE MEMORIAL INSTITUTE
 
<120> PROTEIN PANELS FOR THE EARLY DIAGNOSIS/PROGNOSIS AND TREATMENT OF AGGRESSIVE 
      PROSTATE CANCER

<130> HMJ-172-PCT

<140>
<141>

<150> 62/888,890
<151> 2019-08-19

<160> 118   

<170> PatentIn version 3.5

<210> 1
<211> 750
<212> PRT
<213> Homo sapiens

<400> 1
Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210> 2
<211> 303
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala Ala Pro Gln Gln Glu Ala Leu Pro Asp Glu Thr Glu Val Val Glu 
            20                  25                  30          


Glu Thr Val Ala Glu Val Thr Glu Val Ser Val Gly Ala Asn Pro Val 
        35                  40                  45              


Gln Val Glu Val Gly Glu Phe Asp Asp Gly Ala Glu Glu Thr Glu Glu 
    50                  55                  60                  


Glu Val Val Ala Glu Asn Pro Cys Gln Asn His His Cys Lys His Gly 
65                  70                  75                  80  


Lys Val Cys Glu Leu Asp Glu Asn Asn Thr Pro Met Cys Val Cys Gln 
                85                  90                  95      


Asp Pro Thr Ser Cys Pro Ala Pro Ile Gly Glu Phe Glu Lys Val Cys 
            100                 105                 110         


Ser Asn Asp Asn Lys Thr Phe Asp Ser Ser Cys His Phe Phe Ala Thr 
        115                 120                 125             


Lys Cys Thr Leu Glu Gly Thr Lys Lys Gly His Lys Leu His Leu Asp 
    130                 135                 140                 


Tyr Ile Gly Pro Cys Lys Tyr Ile Pro Pro Cys Leu Asp Ser Glu Leu 
145                 150                 155                 160 


Thr Glu Phe Pro Leu Arg Met Arg Asp Trp Leu Lys Asn Val Leu Val 
                165                 170                 175     


Thr Leu Tyr Glu Arg Asp Glu Asp Asn Asn Leu Leu Thr Glu Lys Gln 
            180                 185                 190         


Lys Leu Arg Val Lys Lys Ile His Glu Asn Glu Lys Arg Leu Glu Ala 
        195                 200                 205             


Gly Asp His Pro Val Glu Leu Leu Ala Arg Asp Phe Glu Lys Asn Tyr 
    210                 215                 220                 


Asn Met Tyr Ile Phe Pro Val His Trp Gln Phe Gly Gln Leu Asp Gln 
225                 230                 235                 240 


His Pro Ile Asp Gly Tyr Leu Ser His Thr Glu Leu Ala Pro Leu Arg 
                245                 250                 255     


Ala Pro Leu Ile Pro Met Glu His Cys Thr Thr Arg Phe Phe Glu Thr 
            260                 265                 270         


Cys Asp Leu Asp Asn Asp Lys Tyr Ile Ala Leu Asp Glu Trp Ala Gly 
        275                 280                 285             


Cys Phe Gly Ile Lys Gln Lys Asp Ile Asp Lys Asp Leu Val Ile 
    290                 295                 300             


<210> 3
<211> 390
<212> PRT
<213> Homo sapiens

<400> 3
Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210> 4
<211> 227
<212> PRT
<213> Homo sapiens

<400> 4
Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Val Ser His Pro Tyr Ser Gln Asp Leu Glu Gly Lys Gly Glu 
    210                 215                 220                 


Trp Gly Pro 
225         


<210> 5
<211> 588
<212> PRT
<213> Homo sapiens

<400> 5
Met Ser Ser Cys Val Ser Ser Gln Pro Ser Ser Asn Arg Ala Ala Pro 
1               5                   10                  15      


Gln Asp Glu Leu Gly Gly Arg Gly Ser Ser Ser Ser Glu Ser Gln Lys 
            20                  25                  30          


Pro Cys Glu Ala Leu Arg Gly Leu Ser Ser Leu Ser Ile His Leu Gly 
        35                  40                  45              


Met Glu Ser Phe Ile Val Val Thr Glu Cys Glu Pro Gly Cys Ala Val 
    50                  55                  60                  


Asp Leu Gly Leu Ala Arg Asp Arg Pro Leu Glu Ala Asp Gly Gln Glu 
65                  70                  75                  80  


Val Pro Leu Asp Thr Ser Gly Ser Gln Ala Arg Pro His Leu Ser Gly 
                85                  90                  95      


Arg Lys Leu Ser Leu Gln Glu Arg Ser Gln Gly Gly Leu Ala Ala Gly 
            100                 105                 110         


Gly Ser Leu Asp Met Asn Gly Arg Cys Ile Cys Pro Ser Leu Pro Tyr 
        115                 120                 125             


Ser Pro Val Ser Ser Pro Gln Ser Ser Pro Arg Leu Pro Arg Arg Pro 
    130                 135                 140                 


Thr Val Glu Ser His His Val Ser Ile Thr Gly Met Gln Asp Cys Val 
145                 150                 155                 160 


Gln Leu Asn Gln Tyr Thr Leu Lys Asp Glu Ile Gly Lys Gly Ser Tyr 
                165                 170                 175     


Gly Val Val Lys Leu Ala Tyr Asn Glu Asn Asp Asn Thr Tyr Tyr Ala 
            180                 185                 190         


Met Lys Val Leu Ser Lys Lys Lys Leu Ile Arg Gln Ala Gly Phe Pro 
        195                 200                 205             


Arg Arg Pro Pro Pro Arg Gly Thr Arg Pro Ala Pro Gly Gly Cys Ile 
    210                 215                 220                 


Gln Pro Arg Gly Pro Ile Glu Gln Val Tyr Gln Glu Ile Ala Ile Leu 
225                 230                 235                 240 


Lys Lys Leu Asp His Pro Asn Val Val Lys Leu Val Glu Val Leu Asp 
                245                 250                 255     


Asp Pro Asn Glu Asp His Leu Tyr Met Val Phe Glu Leu Val Asn Gln 
            260                 265                 270         


Gly Pro Val Met Glu Val Pro Thr Leu Lys Pro Leu Ser Glu Asp Gln 
        275                 280                 285             


Ala Arg Phe Tyr Phe Gln Asp Leu Ile Lys Gly Ile Glu Tyr Leu His 
    290                 295                 300                 


Tyr Gln Lys Ile Ile His Arg Asp Ile Lys Pro Ser Asn Leu Leu Val 
305                 310                 315                 320 


Gly Glu Asp Gly His Ile Lys Ile Ala Asp Phe Gly Val Ser Asn Glu 
                325                 330                 335     


Phe Lys Gly Ser Asp Ala Leu Leu Ser Asn Thr Val Gly Thr Pro Ala 
            340                 345                 350         


Phe Met Ala Pro Glu Ser Leu Ser Glu Thr Arg Lys Ile Phe Ser Gly 
        355                 360                 365             


Lys Ala Leu Asp Val Trp Ala Met Gly Val Thr Leu Tyr Cys Phe Val 
    370                 375                 380                 


Phe Gly Gln Cys Pro Phe Met Asp Glu Arg Ile Met Cys Leu His Ser 
385                 390                 395                 400 


Lys Ile Lys Ser Gln Ala Leu Glu Phe Pro Asp Gln Pro Asp Ile Ala 
                405                 410                 415     


Glu Asp Leu Lys Asp Leu Ile Thr Arg Met Leu Asp Lys Asn Pro Glu 
            420                 425                 430         


Ser Arg Ile Val Val Pro Glu Ile Lys Leu His Pro Trp Val Thr Arg 
        435                 440                 445             


His Gly Ala Glu Pro Leu Pro Ser Glu Asp Glu Asn Cys Thr Leu Val 
    450                 455                 460                 


Glu Val Thr Glu Glu Glu Val Glu Asn Ser Val Lys His Ile Pro Ser 
465                 470                 475                 480 


Leu Ala Thr Val Ile Leu Val Lys Thr Met Ile Arg Lys Arg Ser Phe 
                485                 490                 495     


Gly Asn Pro Phe Glu Gly Ser Arg Arg Glu Glu Arg Ser Leu Ser Ala 
            500                 505                 510         


Pro Gly Asn Leu Leu Thr Lys Lys Pro Thr Arg Glu Cys Glu Ser Leu 
        515                 520                 525             


Ser Glu Leu Lys Glu Ala Arg Gln Arg Arg Gln Pro Pro Gly His Arg 
    530                 535                 540                 


Pro Ala Pro Arg Gly Gly Gly Gly Ser Ala Leu Val Arg Gly Ser Pro 
545                 550                 555                 560 


Cys Val Glu Ser Cys Trp Ala Pro Ala Pro Gly Ser Pro Ala Arg Met 
                565                 570                 575     


His Pro Leu Arg Pro Glu Glu Ala Met Glu Pro Glu 
            580                 585             


<210> 6
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 6
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Lys Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210> 7
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 7
Met Ser Gly Met Gly Glu Asn Thr Ser Asp Pro Ser Arg Ala Glu Thr 
1               5                   10                  15      


Arg Lys Arg Lys Glu Cys Pro Asp Gln Leu Gly Pro Ser Pro Lys Arg 
            20                  25                  30          


Asn Thr Glu Lys Arg Asn Arg Glu Gln Glu Asn Lys Tyr Ile Glu Glu 
        35                  40                  45              


Leu Ala Glu Leu Ile Phe Ala Asn Phe Asn Asp Ile Asp Asn Phe Asn 
    50                  55                  60                  


Phe Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Lys Gln Ile 
65                  70                  75                  80  


Arg Gln Ile Lys Glu Gln Glu Lys Ala Ala Ala Ala Asn Ile Asp Glu 
                85                  90                  95      


Val Gln Lys Ser Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys 
            100                 105                 110         


Asp Ala Leu Gly Pro Met Met Leu Glu Ala Leu Asp Gly Phe Phe Phe 
        115                 120                 125             


Val Val Asn Leu Glu Gly Asn Val Val Phe Val Ser Glu Asn Val Thr 
    130                 135                 140                 


Gln Tyr Leu Arg Tyr Asn Gln Glu Glu Leu Met Asn Lys Ser Val Tyr 
145                 150                 155                 160 


Ser Ile Leu His Val Gly Asp His Thr Glu Phe Val Lys Asn Leu Leu 
                165                 170                 175     


Pro Lys Ser Ile Val Asn Gly Gly Ser Trp Ser Gly Glu Pro Pro Arg 
            180                 185                 190         


Arg Asn Ser His Thr Phe Asn Cys Arg Met Leu Val Lys Pro Leu Pro 
        195                 200                 205             


Asp Ser Glu Glu Glu Gly His Asp Asn Gln Glu Ala His Gln Lys Tyr 
    210                 215                 220                 


Glu Thr Met Gln Cys Phe Ala Val Ser Gln Pro Lys Ser Ile Lys Glu 
225                 230                 235                 240 


Glu Gly Glu Asp Leu Gln Ser Cys Leu Ile Cys Val Ala Arg Arg Val 
                245                 250                 255     


Pro Met Lys Glu Arg Pro Val Leu Pro Ser Ser Glu Ser Phe Thr Thr 
            260                 265                 270         


Arg Gln Asp Leu Gln Gly Lys Ile Thr Ser Leu Asp Thr Ser Thr Met 
        275                 280                 285             


Arg Ala Ala Met Lys Pro Gly Trp Glu Asp Leu Val Arg Arg Cys Ile 
    290                 295                 300                 


Gln Lys Phe His Ala Gln His Glu Gly Glu Ser Val Ser Tyr Ala Lys 
305                 310                 315                 320 


Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln Ile 
                325                 330                 335     


Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr Lys 
            340                 345                 350         


Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val Ile 
        355                 360                 365             


Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn Pro 
    370                 375                 380                 


Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser Ser 
385                 390                 395                 400 


Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln Asp 
                405                 410                 415     


Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys Glu 
            420                 425                 430         


Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met Asn 
        435                 440                 445             


His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr Ala 
    450                 455                 460                 


Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro Gly 
465                 470                 475                 480 


Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly Val 
                485                 490                 495     


Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly Ser 
            500                 505                 510         


Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His Ser 
        515                 520                 525             


Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly His 
    530                 535                 540                 


Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met Gly 
545                 550                 555                 560 


Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser Lys 
                565                 570                 575     


Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu Pro 
            580                 585                 590         


Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly Glu 
        595                 600                 605             


Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser Glu 
    610                 615                 620                 


Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr Lys 
625                 630                 635                 640 


Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser Pro 
                645                 650                 655     


Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser Leu 
            660                 665                 670         


Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu Ala 
    690                 695                 700                 


Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser Ser 
705                 710                 715                 720 


Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val Ser 
                725                 730                 735     


Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
            740                 745                 750         


Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu Arg 
        755                 760                 765             


Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala Met 
    770                 775                 780                 


Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro Gly 
785                 790                 795                 800 


Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn Ser 
                805                 810                 815     


Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala Gly 
            820                 825                 830         


Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr Ala 
        835                 840                 845             


Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu Arg 
    850                 855                 860                 


Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly Arg 
865                 870                 875                 880 


Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser Pro 
                885                 890                 895     


Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr Ser 
            900                 905                 910         


Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly Asn 
        915                 920                 925             


Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser Ala 
    930                 935                 940                 


Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser Ala 
945                 950                 955                 960 


Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro Val 
                965                 970                 975     


Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg Pro 
            980                 985                 990         


Ser Ser Gln Pro Gly Gln Arg Gln  Thr Leu Gln Ser Gln  Val Met Asn 
        995                 1000                 1005             


Ile Gly  Pro Ser Glu Leu Glu  Met Asn Met Gly Gly  Pro Gln Tyr 
    1010                 1015                 1020             


Ser Gln  Gln Gln Ala Pro Pro  Asn Gln Thr Ala Pro  Trp Pro Glu 
    1025                 1030                 1035             


Ser Ile  Leu Pro Ile Asp Gln  Ala Ser Phe Ala Ser  Gln Asn Arg 
    1040                 1045                 1050             


Gln Pro  Phe Gly Ser Ser Pro  Asp Asp Leu Leu Cys  Pro His Pro 
    1055                 1060                 1065             


Ala Ala  Glu Ser Pro Ser Asp  Glu Gly Ala Leu Leu  Asp Gln Leu 
    1070                 1075                 1080             


Tyr Leu  Ala Leu Arg Asn Phe  Asp Gly Leu Glu Glu  Ile Asp Arg 
    1085                 1090                 1095             


Ala Leu  Gly Ile Pro Glu Leu  Val Ser Gln Ser Gln  Ala Val Asp 
    1100                 1105                 1110             


Pro Glu  Gln Phe Ser Ser Gln  Asp Ser Asn Ile Met  Leu Glu Gln 
    1115                 1120                 1125             


Lys Ala  Pro Val Phe Pro Gln  Gln Tyr Ala Ser Gln  Ala Gln Met 
    1130                 1135                 1140             


Ala Gln  Gly Ser Tyr Ser Pro  Met Gln Asp Pro Asn  Phe His Thr 
    1145                 1150                 1155             


Met Gly  Gln Arg Pro Ser Tyr  Ala Thr Leu Arg Met  Gln Pro Arg 
    1160                 1165                 1170             


Pro Gly  Leu Arg Pro Thr Gly  Leu Val Gln Asn Gln  Pro Asn Gln 
    1175                 1180                 1185             


Leu Arg  Leu Gln Leu Gln His  Arg Leu Gln Ala Gln  Gln Asn Arg 
    1190                 1195                 1200             


Gln Pro  Leu Met Asn Gln Ile  Ser Asn Val Ser Asn  Val Asn Leu 
    1205                 1210                 1215             


Thr Leu  Arg Pro Gly Val Pro  Thr Gln Ala Pro Ile  Asn Ala Gln 
    1220                 1225                 1230             


Met Leu  Ala Gln Arg Gln Arg  Glu Ile Leu Asn Gln  His Leu Arg 
    1235                 1240                 1245             


Gln Arg  Gln Met His Gln Gln  Gln Gln Val Gln Gln  Arg Thr Leu 
    1250                 1255                 1260             


Met Met  Arg Gly Gln Gly Leu  Asn Met Thr Pro Ser  Met Val Ala 
    1265                 1270                 1275             


Pro Ser  Gly Ile Pro Ala Thr  Met Ser Asn Pro Arg  Ile Pro Gln 
    1280                 1285                 1290             


Ala Asn  Ala Gln Gln Phe Pro  Phe Pro Pro Asn Tyr  Gly Ile Ser 
    1295                 1300                 1305             


Gln Gln  Pro Asp Pro Gly Phe  Thr Gly Ala Thr Thr  Pro Gln Ser 
    1310                 1315                 1320             


Pro Leu  Met Ser Pro Arg Met  Ala His Thr Gln Ser  Pro Met Met 
    1325                 1330                 1335             


Gln Gln  Ser Gln Ala Asn Pro  Ala Tyr Gln Ala Pro  Ser Asp Ile 
    1340                 1345                 1350             


Asn Gly  Trp Ala Gln Gly Asn  Met Gly Gly Asn Ser  Met Phe Ser 
    1355                 1360                 1365             


Gln Gln  Ser Pro Pro His Phe  Gly Gln Gln Ala Asn  Thr Ser Met 
    1370                 1375                 1380             


Tyr Ser  Asn Asn Met Asn Ile  Asn Val Ser Met Ala  Thr Asn Thr 
    1385                 1390                 1395             


Gly Gly  Met Ser Ser Met Asn  Gln Met Thr Gly Gln  Ile Ser Met 
    1400                 1405                 1410             


Thr Ser  Val Thr Ser Val Pro  Thr Ser Gly Leu Ser  Ser Met Gly 
    1415                 1420                 1425             


Pro Glu  Gln Val Asn Asp Pro  Ala Leu Arg Gly Gly  Asn Leu Phe 
    1430                 1435                 1440             


Pro Asn  Gln Leu Pro Gly Met  Asp Met Ile Lys Gln  Glu Gly Asp 
    1445                 1450                 1455             


Thr Thr  Arg Lys Tyr Cys 
    1460                 


<210> 8
<211> 8
<212> PRT
<213> Homo sapiens

<400> 8
Gly Gly Glu Ile Glu Gly Phe Arg 
1               5               


<210> 9
<211> 16
<212> PRT
<213> Homo sapiens

<400> 9
Gly Leu Gly Thr Asp Glu Asp Ser Leu Ile Glu Ile Ile Cys Ser Arg 
1               5                   10                  15      


<210> 10
<211> 11
<212> PRT
<213> Homo sapiens

<400> 10
Ser Leu Ser Ala Pro Gly Asn Leu Leu Thr Lys 
1               5                   10      


<210> 11
<211> 11
<212> PRT
<213> Homo sapiens

<400> 11
Ala Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg 
1               5                   10      


<210> 12
<211> 16
<212> PRT
<213> Homo sapiens

<400> 12
Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg 
1               5                   10                  15      


<210> 13
<211> 16
<212> PRT
<213> Homo sapiens

<400> 13
Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg 
1               5                   10                  15      


<210> 14
<211> 14
<212> PRT
<213> Homo sapiens

<400> 14
Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys 
1               5                   10                  


<210> 15
<211> 15
<212> PRT
<213> Homo sapiens

<400> 15
Leu Gly Leu Gly Ala Asp Val Ala Gln Val Thr Gly Ala Leu Arg 
1               5                   10                  15  


<210> 16
<211> 11
<212> PRT
<213> Homo sapiens

<400> 16
Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys 
1               5                   10      


<210> 17
<211> 13
<212> PRT
<213> Homo sapiens

<400> 17
Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu Ala Lys 
1               5                   10              


<210> 18
<211> 11
<212> PRT
<213> Homo sapiens

<400> 18
Leu Ser Glu Pro Ala Glu Thr Asp Ala Val Lys 
1               5                   10      


<210> 19
<211> 9
<212> PRT
<213> Homo sapiens

<400> 19
Tyr Cys Gln Tyr Ala Phe Asp Leu Lys 
1               5                   


<210> 20
<211> 8
<212> PRT
<213> Homo sapiens

<400> 20
Gln Thr Ser Ile Leu Ile Gln Lys 
1               5               


<210> 21
<211> 13
<212> PRT
<213> Homo sapiens

<400> 21
Leu Glu Ala Gly Asp His Pro Val Glu Leu Leu Ala Arg 
1               5                   10              


<210> 22
<211> 11
<212> PRT
<213> Homo sapiens

<400> 22
Val Asp Cys Gly Tyr Pro His Val Thr Pro Lys 
1               5                   10      


<210> 23
<211> 7
<212> PRT
<213> Homo sapiens

<400> 23
Phe Met Asp Val Tyr Gln Arg 
1               5           


<210> 24
<211> 18
<212> PRT
<213> Homo sapiens

<400> 24
Ile Pro Gly Val Pro Trp Cys Phe Lys Pro Leu Gln Glu Ala Glu Cys 
1               5                   10                  15      


Thr Phe 
        


<210> 25
<211> 11
<212> PRT
<213> Homo sapiens

<400> 25
Asp Glu Val Ala His Thr Leu Thr Glu Asn Arg 
1               5                   10      


<210> 26
<211> 17
<212> PRT
<213> Homo sapiens

<400> 26
Phe Tyr Gly Ala Glu Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu 
1               5                   10                  15      


Lys 
    


<210> 27
<211> 10
<212> PRT
<213> Homo sapiens

<400> 27
Leu Gln Leu Gly Pro Glu Ile Leu Gln Arg 
1               5                   10  


<210> 28
<211> 12
<212> PRT
<213> Homo sapiens

<400> 28
Leu Ser Gly Phe Gly Gln Ser Gly Ser Phe Cys Arg 
1               5                   10          


<210> 29
<211> 14
<212> PRT
<213> Homo sapiens

<400> 29
Ala Leu Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys 
1               5                   10                  


<210> 30
<211> 14
<212> PRT
<213> Homo sapiens

<400> 30
Met Leu Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg 
1               5                   10                  


<210> 31
<211> 11
<212> PRT
<213> Homo sapiens

<400> 31
Ser Leu Tyr Tyr Tyr Ile Gln Gln Asp Thr Lys 
1               5                   10      


<210> 32
<211> 14
<212> PRT
<213> Homo sapiens

<400> 32
Val Glu Phe Thr Phe Pro Asp Phe Val Thr Glu Gly Ala Arg 
1               5                   10                  


<210> 33
<211> 10
<212> PRT
<213> Homo sapiens

<400> 33
Val Leu Cys Pro Ser Asn Ser Ser Gln Arg 
1               5                   10  


<210> 34
<211> 17
<212> PRT
<213> Homo sapiens

<400> 34
Ala Gly Phe Gln Thr Glu Asp Phe Ser Leu Tyr Ala Cys Ala Ser Pro 
1               5                   10                  15      


Lys 
    


<210> 35
<211> 12
<212> PRT
<213> Homo sapiens

<400> 35
Leu Thr Gln Glu His Ile Glu Ala Leu Leu Asp Lys 
1               5                   10          


<210> 36
<211> 10
<212> PRT
<213> Homo sapiens

<400> 36
Ser Phe Gly Asn Pro Phe Glu Gly Ser Arg 
1               5                   10  


<210> 37
<211> 13
<212> PRT
<213> Homo sapiens

<400> 37
Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys 
1               5                   10              


<210> 38
<211> 14
<212> PRT
<213> Homo sapiens

<400> 38
Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln Glu Ala Arg 
1               5                   10                  


<210> 39
<211> 12
<212> PRT
<213> Homo sapiens

<400> 39
Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Ser Arg 
1               5                   10          


<210> 40
<211> 8
<212> PRT
<213> Homo sapiens

<400> 40
Trp Ala Asn Gln Cys Asn Tyr Arg 
1               5               


<210> 41
<211> 9
<212> PRT
<213> Homo sapiens

<400> 41
Tyr Glu Asp Leu Tyr Ser Asn Cys Lys 
1               5                   


<210> 42
<211> 14
<212> PRT
<213> Homo sapiens

<400> 42
Phe Glu Glu Ile Thr Gly Val Ile Asn Pro Ala Leu Asp Lys 
1               5                   10                  


<210> 43
<211> 16
<212> PRT
<213> Homo sapiens

<400> 43
Tyr Tyr Ser Ser Ser Ile Trp Gly Pro Thr Cys Asp Gly Leu Asp Arg 
1               5                   10                  15      


<210> 44
<211> 11
<212> PRT
<213> Homo sapiens

<400> 44
Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg 
1               5                   10      


<210> 45
<211> 13
<212> PRT
<213> Homo sapiens

<400> 45
Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg 
1               5                   10              


<210> 46
<211> 14
<212> PRT
<213> Homo sapiens

<400> 46
Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg 
1               5                   10                  


<210> 47
<211> 13
<212> PRT
<213> Homo sapiens

<400> 47
Ile Gly Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys 
1               5                   10              


<210> 48
<211> 13
<212> PRT
<213> Homo sapiens

<400> 48
Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu Lys 
1               5                   10              


<210> 49
<211> 17
<212> PRT
<213> Homo sapiens

<400> 49
Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val 
1               5                   10                  15      


Lys 
    


<210> 50
<211> 12
<212> PRT
<213> Homo sapiens

<400> 50
Ser Pro Asn Val Leu Ser Val Ala Leu Ser Gln Arg 
1               5                   10          


<210> 51
<211> 14
<212> PRT
<213> Homo sapiens

<400> 51
Ser Ser Ala Asp Pro Ala Leu Asn Gln Glu Val Ala Leu Lys 
1               5                   10                  


<210> 52
<211> 10
<212> PRT
<213> Homo sapiens

<400> 52
Ala Leu Thr His Ser Glu Leu Asp Val Arg 
1               5                   10  


<210> 53
<211> 12
<212> PRT
<213> Homo sapiens

<400> 53
Leu Leu Glu Val Ile Ser Val Cys Asp Cys Pro Arg 
1               5                   10          


<210> 54
<211> 17
<212> PRT
<213> Homo sapiens

<400> 54
Leu Ala Thr Gln Ser Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser 
1               5                   10                  15      


Arg 
    


<210> 55
<211> 10
<212> PRT
<213> Homo sapiens

<400> 55
Leu Phe Asp Gln Ala Phe Gly Leu Pro Arg 
1               5                   10  


<210> 56
<211> 13
<212> PRT
<213> Homo sapiens

<400> 56
His Phe Ser Thr Tyr Gly Ala Ala Val Ala Gln Asn Arg 
1               5                   10              


<210> 57
<211> 19
<212> PRT
<213> Homo sapiens

<400> 57
Ile Tyr Ser Thr Pro Phe Tyr Ser Pro Gln Glu Asn Val Val Phe Ser 
1               5                   10                  15      


Ser Ser Arg 
            


<210> 58
<211> 11
<212> PRT
<213> Homo sapiens

<400> 58
Leu Leu Cys Gly Ala Thr Leu Ile Ala Pro Arg 
1               5                   10      


<210> 59
<211> 12
<212> PRT
<213> Homo sapiens

<400> 59
Trp Leu Leu Thr Ala Ala His Cys Leu Lys Pro Arg 
1               5                   10          


<210> 60
<211> 8
<212> PRT
<213> Homo sapiens

<400> 60
Asn Ser Gln Val Trp Leu Gly Arg 
1               5               


<210> 61
<211> 17
<212> PRT
<213> Homo sapiens

<400> 61
Ser Leu Gln Cys Val Ser Leu His Leu Leu Ser Asn Asp Met Cys Ala 
1               5                   10                  15      


Arg 
    


<210> 62
<211> 12
<212> PRT
<213> Homo sapiens

<400> 62
Ala Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg 
1               5                   10          


<210> 63
<211> 9
<212> PRT
<213> Homo sapiens

<400> 63
Val Asp Ala Ala Phe Asn Trp Ser Lys 
1               5                   


<210> 64
<211> 9
<212> PRT
<213> Homo sapiens

<400> 64
Phe Gln Thr Phe Glu Gly Asp Leu Lys 
1               5                   


<210> 65
<211> 11
<212> PRT
<213> Homo sapiens

<400> 65
Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg 
1               5                   10      


<210> 66
<211> 12
<212> PRT
<213> Homo sapiens

<400> 66
Val Tyr His Leu Pro Tyr Tyr Glu Ala Cys Val Arg 
1               5                   10          


<210> 67
<211> 8
<212> PRT
<213> Homo sapiens

<400> 67
Gly Val Leu Leu Trp Gly Trp Arg 
1               5               


<210> 68
<211> 14
<212> PRT
<213> Homo sapiens

<400> 68
Ala Thr Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys 
1               5                   10                  


<210> 69
<211> 17
<212> PRT
<213> Homo sapiens

<400> 69
Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser Leu 
1               5                   10                  15      


Arg 
    


<210> 70
<211> 19
<212> PRT
<213> Homo sapiens

<400> 70
Ala Thr Glu Tyr Val His Ser Leu Gln Ala Glu Glu His Gln Leu Leu 
1               5                   10                  15      


Leu Glu Lys 
            


<210> 71
<211> 13
<212> PRT
<213> Homo sapiens

<400> 71
Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
1               5                   10              


<210> 72
<211> 15
<212> PRT
<213> Homo sapiens

<400> 72
Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys 
1               5                   10                  15  


<210> 73
<211> 13
<212> PRT
<213> Homo sapiens

<400> 73
Thr Val Tyr Ser His Leu Phe Asp His Val Val Asn Arg 
1               5                   10              


<210> 74
<211> 10
<212> PRT
<213> Homo sapiens

<400> 74
Asn Phe Asp Gly Leu Glu Glu Ile Asp Arg 
1               5                   10  


<210> 75
<211> 8
<212> PRT
<213> Homo sapiens

<400> 75
His Tyr Ile Asn Leu Ile Thr Arg 
1               5               


<210> 76
<211> 13
<212> PRT
<213> Homo sapiens

<400> 76
Ser Ser Pro Glu Thr Leu Ile Ser Asp Leu Leu Met Arg 
1               5                   10              


<210> 77
<211> 10
<212> PRT
<213> Homo sapiens

<400> 77
Phe Gly Asn Ser Leu His Pro Ile Val Arg 
1               5                   10  


<210> 78
<211> 8
<212> PRT
<213> Homo sapiens

<400> 78
Thr Val Leu Gln Leu Pro Ser Lys 
1               5               


<210> 79
<211> 17
<212> PRT
<213> Homo sapiens

<400> 79
Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser 
1               5                   10                  15      


Arg 
    


<210> 80
<211> 16
<212> PRT
<213> Homo sapiens

<400> 80
Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro Ser Gln Lys 
1               5                   10                  15      


<210> 81
<211> 15
<212> PRT
<213> Homo sapiens

<400> 81
Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
1               5                   10                  15  


<210> 82
<211> 10
<212> PRT
<213> Homo sapiens

<400> 82
Leu Gly Phe Leu His Ser Gly Thr Ala Lys 
1               5                   10  


<210> 83
<211> 21
<212> PRT
<213> Homo sapiens

<400> 83
Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu Tyr Phe Gln Tyr Pro 
1               5                   10                  15      


Ala Asn Ile Ile Lys 
            20      


<210> 84
<211> 14
<212> PRT
<213> Homo sapiens

<400> 84
Tyr Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg 
1               5                   10                  


<210> 85
<211> 15
<212> PRT
<213> Homo sapiens

<400> 85
Glu Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg 
1               5                   10                  15  


<210> 86
<211> 11
<212> PRT
<213> Homo sapiens

<400> 86
Val Val Glu Gly Thr Ala Tyr Gly Leu Ser Arg 
1               5                   10      


<210> 87
<211> 9
<212> PRT
<213> Homo sapiens

<400> 87
Leu Ile Asn Leu Thr Asp Ile Leu Lys 
1               5                   


<210> 88
<211> 11
<212> PRT
<213> Homo sapiens

<400> 88
Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg 
1               5                   10      


<210> 89
<211> 9
<212> PRT
<213> Homo sapiens

<400> 89
Thr Ile Ser Asn Gly Phe Gly Phe Lys 
1               5                   


<210> 90
<211> 13
<212> PRT
<213> Homo sapiens

<400> 90
Val Val Asp Pro Thr Pro Glu Gln Phe Gln Ala Phe Arg 
1               5                   10              


<210> 91
<211> 10
<212> PRT
<213> Homo sapiens

<400> 91
Ala Leu Gly Ile Thr Glu Ile Phe Ile Lys 
1               5                   10  


<210> 92
<211> 9
<212> PRT
<213> Homo sapiens

<400> 92
Asn Gly Glu Glu Phe Ser Phe Leu Lys 
1               5                   


<210> 93
<211> 10
<212> PRT
<213> Homo sapiens

<400> 93
Cys Tyr Asn Glu Leu Asn Gly Cys Thr Lys 
1               5                   10  


<210> 94
<211> 12
<212> PRT
<213> Homo sapiens

<400> 94
Ala Pro Leu Ile Pro Met Glu His Cys Thr Thr Arg 
1               5                   10          


<210> 95
<211> 11
<212> PRT
<213> Homo sapiens

<400> 95
Glu Ala Val Pro Glu Pro Val Leu Leu Ser Arg 
1               5                   10      


<210> 96
<211> 8
<212> PRT
<213> Homo sapiens

<400> 96
Val Leu Leu Ile Glu Thr Gln Arg 
1               5               


<210> 97
<211> 15
<212> PRT
<213> Homo sapiens

<400> 97
Val Leu Thr Gln Ala Ser Asn Pro Val Val Cys Thr Gln Pro Lys 
1               5                   10                  15  


<210> 98
<211> 15
<212> PRT
<213> Homo sapiens

<400> 98
His Ile Ala Glu Asp Ser Asp Arg Lys Tyr Glu Glu Val Ala Arg 
1               5                   10                  15  


<210> 99
<211> 11
<212> PRT
<213> Homo sapiens

<400> 99
Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys 
1               5                   10      


<210> 100
<211> 11
<212> PRT
<213> Homo sapiens

<400> 100
Met Ala Ser Cys Ser Tyr Val Ala His Glu Arg 
1               5                   10      


<210> 101
<211> 17
<212> PRT
<213> Homo sapiens

<400> 101
Tyr Ile Asp Phe Leu Tyr Gln Val Leu Gln Ser Asp Glu Leu Asp Ser 
1               5                   10                  15      


Lys 
    


<210> 102
<211> 11
<212> PRT
<213> Homo sapiens

<400> 102
His Leu Phe Val Gln Asp Pro Gln Thr Cys Lys 
1               5                   10      


<210> 103
<211> 9
<212> PRT
<213> Homo sapiens

<400> 103
Ile Val Gly Gly Trp Glu Cys Glu Lys 
1               5                   


<210> 104
<211> 12
<212> PRT
<213> Homo sapiens

<400> 104
Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val Lys 
1               5                   10          


<210> 105
<211> 16
<212> PRT
<213> Homo sapiens

<400> 105
Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys 
1               5                   10                  15      


<210> 106
<211> 12
<212> PRT
<213> Homo sapiens

<400> 106
Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg 
1               5                   10          


<210> 107
<211> 19
<212> PRT
<213> Homo sapiens

<400> 107
Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met 
1               5                   10                  15      


Glu Glu Lys 
            


<210> 108
<211> 12
<212> PRT
<213> Homo sapiens

<400> 108
His Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg 
1               5                   10          


<210> 109
<211> 13
<212> PRT
<213> Homo sapiens

<400> 109
Ile Thr Thr Arg Pro Asp Leu Pro Tyr Glu Pro Pro Arg 
1               5                   10              


<210> 110
<211> 10
<212> PRT
<213> Homo sapiens

<400> 110
Asn Thr Asp Leu Pro Tyr Glu Pro Pro Arg 
1               5                   10  


<210> 111
<211> 6
<212> PRT
<213> Homo sapiens

<400> 111
Phe Ser Tyr Gly Glu Lys 
1               5       


<210> 112
<211> 10
<212> PRT
<213> Homo sapiens

<400> 112
Gln Glu Gly Phe Leu Ala His Pro Ser Arg 
1               5                   10  


<210> 113
<211> 9
<212> PRT
<213> Homo sapiens

<400> 113
Leu Ile Glu Pro Glu Glu Val Ala Arg 
1               5                   


<210> 114
<211> 8
<212> PRT
<213> Homo sapiens

<400> 114
Ile Thr Thr Arg Pro Gly Thr Lys 
1               5               


<210> 115
<211> 8
<212> PRT
<213> Homo sapiens

<400> 115
Ala Leu Ser His Val Ile Gln Arg 
1               5               


<210> 116
<211> 9
<212> PRT
<213> Homo sapiens

<400> 116
Gly Phe Pro His Val Ile Tyr Ala Arg 
1               5                   


<210> 117
<211> 9
<212> PRT
<213> Homo sapiens

<400> 117
Phe Pro Glu Leu Asn Tyr Gln Leu Lys 
1               5                   


<210> 118
<211> 13
<212> PRT
<213> Homo sapiens

<400> 118
Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu Ala Glu Lys 
1               5                   10              


