                               SEQUENCE LISTING

<110> APPLIED MOLECULAR TRANSPORT INC.
 
<120> COMPOSITIONS, FORMULATIONS, AND INTERLEUKIN PRODUCTION AND 
      PURIFICATION

<130> 40566-721.601

<140>
<141>

<150> 63/055,886
<151> 2020-07-23

<150> 63/033,077
<151> 2020-06-01

<150> 63/020,996
<151> 2020-05-06

<150> 63/013,309
<151> 2020-04-21

<150> 62/986,579
<151> 2020-03-06

<150> 62/971,126
<151> 2020-02-06

<150> 62/970,627
<151> 2020-02-05

<150> 62/939,495
<151> 2019-11-22

<150> 62/898,934
<151> 2019-09-11

<150> 62/898,709
<151> 2019-09-11

<150> 62/898,729
<151> 2019-09-11

<150> 62/898,899
<151> 2019-09-11

<150> 62/888,144
<151> 2019-08-16

<150> 62/888,237
<151> 2019-08-16

<150> 62/887,963
<151> 2019-08-16

<150> 62/887,933
<151> 2019-08-16

<160> 156   

<170> PatentIn version 3.5

<210> 1
<211> 178
<212> PRT
<213> Homo sapiens

<400> 1
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 2
<211> 160
<212> PRT
<213> Homo sapiens

<400> 2
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                  15      


Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                  25                  30          


Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                  40                  45              


Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                  55                  60                  


Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                  70                  75                  80  


Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                  90                  95      


Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                 105                 110         


Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                 120                 125             


Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                 135                 140                 


Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                 150                 155                 160 


<210> 3
<211> 634
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 4
<211> 386
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala 
385     


<210> 5
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe 
                405                 410                 415     


Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser 
            420                 425                 430         


Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu 
        435                 440                 445             


Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln 
    450                 455                 460                 


Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln 
465                 470                 475                 480 


Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly 
                485                 490                 495     


Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe 
            500                 505                 510         


Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala 
        515                 520                 525             


Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe 
    530                 535                 540                 


Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg 
545                 550                 555                 560 


Asn 
    


<210> 6
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210> 7
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(60) 
<223> This sequence may encompass 1-15 "Gly Gly Gly Ser"
      repeating units

<400> 7
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60  


<210> 8
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(75) 
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Ser"
      repeating units

<400> 8
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  


<210> 9
<211> 90
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(90) 
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Gly Ser"
      repeating units

<400> 9
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
                85                  90  


<210> 10
<211> 1683
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atggtagaag aagcgctgaa tatttttgac gagtgtcgta gcccgtgtag cctgactccg       60

gaaccgggca agccgattca gtccaaactg tctatcccga gcgacgttgt gctggatgag      120

ggcgtgttgt attacagcat gacgatcaat gatgagcaaa acgacatcaa agacgaagat      180

aagggtgagt ctattatcac cattggcgag tttgcgacgg tgcgtgcaac gcgccattac      240

gtgaatcaag acgcgccgtt tggtgtcatt cacctggata tcacgaccga aaatggcacg      300

aaaacctatt cgtataatcg caaagagggc gagttcgcga tcaactggct ggttccgatc      360

ggtgaggata gcccggcgag catcaagatc agcgttgatg aactggatca gcagcgcaac      420

attattgaag tcccgaagtt gtatagcatc gacctggata atcagaccct ggagcagtgg      480

aaaacccagg gtaacgttag cttctccgtg acccgtccgg agcacaacat tgccattagc      540

tggccgagcg ttagctacaa agccgcacag aaagagggtt cccgccacaa gcgttgggct      600

cattggcata ccggtttggc gctgtgttgg ctggtgccga tggatgcgat ctataactac      660

atcacgcagc aaaattgcac gctgggtgac aattggttcg gtggcagcta cgagactgtg      720

gcgggtaccc ctaaggttat taccgtcaaa cagggtattg agcaaaagcc tgtcgagcag      780

cgtatccact ttagcaaggg taacgccatg tctgctctgg cggctcatag agtttgcggc      840

gttccgctgg agactctggc ccgttcccgc aagccgcgtg acctgaccga tgacctgagc      900

tgcgcgtatc aagcgcaaaa cattgttagc ttattcgttg cgacgcgcat tttgttttcg      960

cacctggata gcgtgttcac gctgaacctg gatgaacagg aaccagaagt ggcagagcgt     1020

ctgtcagatc tgcgtcgtat caacgaaaac aacccgggca tggttaccca ggtccttacg     1080

gttgcacgcc agatttacaa tgattacgtg acccatcacc cgggtctgac cccagaacaa     1140

accagcgcag gcgcacaagc gggtggcggt ggttccggtg gcggtggtag cggtggcggt     1200

ggtagccctg gtcaaggcac ccaatccgag aatagctgca cgcattttcc aggcaatctg     1260

ccgaatatgc tgcgtgacct ccgcgacgcg ttctctcgtg ttaagacctt ttttcagatg     1320

aaagaccagc tggacaatct gctgctgaaa gaatccctgc tggaagattt caaaggctat     1380

ctgggttgcc aggccctgag cgagatgatc caattctact tggaagaggt catgccgcag     1440

gccgaaaatc aagacccgga catcaaggca cacgtgaaca gcttgggcga aaacctgaaa     1500

accctgcgtt tgcgcctgcg tcgttgtcac cgtttcctgc cgtgcgagaa taagagcaaa     1560

gccgtcgaac aagtcaaaaa tgcattcaac aagctgcaag agaaaggtat ctacaaggct     1620

atgagcgagt ttgacatttt cattaactac attgaagcgt acatgaccat gaagatccgt     1680

aac                                                                   1683


<210> 11
<211> 634
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 12
<211> 386
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala 
385     


<210> 13
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Leu Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys 
1               5                   10                  15      


Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile 
            20                  25                  30          


Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr 
        35                  40                  45              


Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser 
    50                  55                  60                  


Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr 
65                  70                  75                  80  


Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr 
                85                  90                  95      


Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe 
            100                 105                 110         


Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile 
        115                 120                 125             


Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val 
    130                 135                 140                 


Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp 
145                 150                 155                 160 


Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn 
                165                 170                 175     


Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu 
            180                 185                 190         


Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu 
        195                 200                 205             


Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln 
    210                 215                 220                 


Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val 
225                 230                 235                 240 


Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
                245                 250                 255     


Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala 
            260                 265                 270         


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
        275                 280                 285             


Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln 
    290                 295                 300                 


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
305                 310                 315                 320 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
                325                 330                 335     


Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro 
            340                 345                 350         


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
        355                 360                 365             


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
    370                 375                 380                 


Ala Gln Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe 
                405                 410                 415     


Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser 
            420                 425                 430         


Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu 
        435                 440                 445             


Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln 
    450                 455                 460                 


Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln 
465                 470                 475                 480 


Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly 
                485                 490                 495     


Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe 
            500                 505                 510         


Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala 
        515                 520                 525             


Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe 
    530                 535                 540                 


Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg 
545                 550                 555                 560 


Asn 
    


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
gctcattgct gggtacttac aa                                                22


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ccagacttgg cacaagacag g                                                 21


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cacagcagca catcaacaag                                                   20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
gtgctcatgt cctcatcctg                                                   20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
tgtgtccgtc gtggatctga                                                   20


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
cctgcttcac caccttcttg a                                                 21


<210> 20
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 20
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Leu Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 21
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 21
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Ala Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Val Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Asn Gly Gly Leu Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 22
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 22
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Asn Gly Gly Leu Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Asp Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 23
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 23
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Met Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Tyr Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Arg Val 
                565                 570                 575     


Asp Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Pro Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 24
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 24
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Asp Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Ile Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asp Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 25
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 25
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Asp Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys His 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 26
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 26
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp Arg Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 27
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 27
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Asn Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 28
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 28
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Leu Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 29
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 29
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Lys Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 30
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 30
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile Tyr Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 31
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 31
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 32
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 32
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile Tyr Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 33
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 33
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Lys Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 34
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 34
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Arg Val 
                565                 570                 575     


Asp Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 35
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 35
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Asn Gly Gly Leu Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Asp Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 36
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 36
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile His Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 37
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 37
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Ile Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 38
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 38
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Phe Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 39
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 39
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala 
    290                 295                 300                 


Gln Gln Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr His 
305                 310                 315                 320 


Ile Asp Ser Ile Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Ile Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Gln Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Gln Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Ser Pro Val Pro Arg Gly 
465                 470                 475                 480 


Ser Asp Thr Glu Ser Glu Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr 
                485                 490                 495     


Asp Ala Ser Val Ala Tyr Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala 
            500                 505                 510         


Asp Gly Gly Gly Leu Thr Pro Ala Glu Arg Lys Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Leu Pro Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile 
    530                 535                 540                 


Asn Ala Asp Leu Glu Lys Glu Arg Asn Leu Val Glu Arg Val Ile Gly 
545                 550                 555                 560 


His Pro Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu 
                565                 570                 575     


Glu Gly Ser Asp Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 40
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 40
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 41
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 41
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asp Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 42
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 42
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Asn Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 43
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 43
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Ile Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 44
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 44
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 45
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 45
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Thr Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 46
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 46
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 47
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 47
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Thr Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 48
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 48
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Leu 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 49
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 49
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Ile Pro Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Thr Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 50
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 50
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630             


<210> 51
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 51
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Gln Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630             


<210> 52
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 52
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630             


<210> 53
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 53
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630             


<210> 54
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 54
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630             


<210> 55
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 55
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Ile Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630             


<210> 56
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 56
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Ile Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630             


<210> 57
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 57
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Glu Val 
        195                 200                 205             


Val Leu Cys Phe Phe Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln Gln Ile Val Ser Leu 
    290                 295                 300                 


Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile Asp Ser Ile Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala Glu Arg Leu Asp Asp 
                325                 330                 335     


Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Ile Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Ser 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Gln Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630             


<210> 58
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 58
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Asp Gly 
            180                 185                 190         


Ala Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Leu Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Met Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Gly 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Gln Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Thr Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Ile Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr Glu His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Glu Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Lys His Gln Thr 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Thr Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Lys Glu Glu Glu Trp Gly Gly Val Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Leu Ala His Arg Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Asn Gly Leu Pro Thr Thr Glu Glu Lys Lys Ser Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Leu Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Ile Pro Leu Glu Asn Ala Asp Glu His Val Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Pro Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu His Asp Glu Leu Lys 
625                 630             


<210> 59
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 59
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Asp Gly 
            180                 185                 190         


Ala Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Leu Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Met Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Gly 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Gln Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Thr Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Ile Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr Glu His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Glu Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Lys His Gln Thr 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Thr Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Lys Glu Glu Glu Trp Gly Gly Val Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Asn His Arg Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Asn Gly Leu Pro Thr Thr Glu Glu Lys Lys Ser Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Leu Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Ile Pro Leu Glu Asn Ala Asp Glu His Val Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Pro Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu His Asp Glu Leu Lys 
625                 630             


<210> 60
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 60
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Asp Gly 
            180                 185                 190         


Ala Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Leu Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Met Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Gly 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Gln Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Thr Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Ile Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr Glu His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Glu Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Lys His Gln Thr 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Thr Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Lys Glu Glu Glu Trp Gly Gly Val Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Leu Ala His Arg Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Asn Gly Leu Pro Thr Thr Glu Lys Lys Lys Ser Arg Gly Val Met 
        515                 520                 525             


Leu Lys Val Tyr Leu Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Ile Pro Leu Glu Asn Ala Asp Glu His Val Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Pro Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asn Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu His Asp Glu Leu Lys 
625                 630             


<210> 61
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 61
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630             


<210> 62
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 62
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Ile Pro Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Gly Leu Thr Thr Asp Glu Glu Ala Val 
        595                 600                 605             


Val Lys Glu Ala Ile Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
    610                 615                 620                 


Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630             


<210> 63
<211> 633
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 63
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Ile Pro Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Asp Gly 
            180                 185                 190         


Ala Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Leu Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Met Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Gly 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Gln Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Thr Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Ile Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr Glu His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Glu Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Lys His Gln Thr 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Thr Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Lys Glu Glu Glu Trp Gly Gly Val Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Leu Ala His Arg Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Asn Gly Leu Pro Thr Thr Glu Glu Lys Lys Ser Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Leu Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Ile Pro Leu Glu Asn Ala Asp Glu His Val Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Pro Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu His Asp Glu Leu Lys 
625                 630             


<210> 64
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 64
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 65
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 65
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 66
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 66
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Asn Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Val Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 67
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 67
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Asn Gly Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 68
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 68
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Arg Val Asp Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 69
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 69
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Met Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Arg Val Asp Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 70
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 70
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Lys Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Glu Pro Glu Leu Cys Thr Tyr Gly Glu Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Glu Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Gln Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Ala Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 71
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 71
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Glu Val 
        195                 200                 205             


Val Leu Cys Phe Phe Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln Gln Ile Val Ser Leu 
    290                 295                 300                 


Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile Asp Ser Ile Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala Glu Arg Leu Asp Asp 
                325                 330                 335     


Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Ile Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Ser 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Gln Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Ser Ile 
    450                 455                 460                 


Val Asn Arg Ile Ser Pro Val Pro Arg Gly Ser Asp Thr Glu Ser Glu 
465                 470                 475                 480 


Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr Asp Ala Ser Val Ala Tyr 
                485                 490                 495     


Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala Asp Gly Gly Gly Leu Thr 
            500                 505                 510         


Pro Ala Glu Arg Lys Ala Arg Gly Val Met Leu Arg Val Tyr Leu Pro 
        515                 520                 525             


Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile Asn Ala Asp Leu Glu Lys 
    530                 535                 540                 


Glu Arg Asn Leu Val Glu Arg Val Ile Gly His Pro Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu Glu Gly Ser Asp Glu Thr 
                565                 570                 575     


Ala Ile Gly Trp Asp Met Ala Ile His Gly Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 72
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 72
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Glu Val 
        195                 200                 205             


Val Leu Cys Phe Phe Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln Gln Ile Val Ser Leu 
    290                 295                 300                 


Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile Asp Ser Ile Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala Glu Arg Leu Asp Asp 
                325                 330                 335     


Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Ile Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Leu 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Ser 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Gln Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Ser Ile 
    450                 455                 460                 


Val Asn Arg Ile Ser Pro Val Pro Arg Gly Ser Asp Thr Glu Ser Glu 
465                 470                 475                 480 


Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr Asp Ala Ser Val Ala Tyr 
                485                 490                 495     


Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala Asp Gly Gly Gly Leu Thr 
            500                 505                 510         


Pro Ala Glu Arg Lys Ala Arg Gly Val Met Leu Arg Val Tyr Leu Pro 
        515                 520                 525             


Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile Asn Ala Asp Leu Glu Lys 
    530                 535                 540                 


Glu Arg Asn Leu Val Glu Arg Val Ile Gly His Pro Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu Glu Gly Ser Asp Glu Thr 
                565                 570                 575     


Ala Ile Gly Trp Asp Met Ala Ile His Gly Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 73
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 73
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Glu Val 
        195                 200                 205             


Val Leu Cys Phe Phe Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln Gln Ile Val Ser Leu 
    290                 295                 300                 


Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile Asp Ser Ile Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala Glu Arg Leu Asp Asp 
                325                 330                 335     


Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Ile Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Ser 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Gln Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Ser Ile 
    450                 455                 460                 


Val Asn Arg Ile Ser Pro Val Pro Arg Gly Ser Asp Thr Glu Ser Glu 
465                 470                 475                 480 


Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr Asp Ala Ser Val Ala Tyr 
                485                 490                 495     


Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala Asp Gly Gly Gly Leu Thr 
            500                 505                 510         


Pro Ala Glu Arg Lys Ala Arg Gly Val Met Leu Arg Val Tyr Leu Pro 
        515                 520                 525             


Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile Asn Ala Asp Leu Glu Lys 
    530                 535                 540                 


Glu Arg Asn Leu Val Glu Arg Val Ile Gly His Pro Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu Glu Gly Ser Asp Glu Thr 
                565                 570                 575     


Ala Ile Gly Trp Asp Met Ala Ile His Gly Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 74
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 74
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Phe Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Ile Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Ala Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 75
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 75
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro Lys Val 
        195                 200                 205             


Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp Tyr Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Thr Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Asp Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 76
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 76
Val Glu Asp Glu Leu Lys Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 77
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 77
Val Glu Asp Glu Leu Lys Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Ala Pro Glu Val Ala Glu Arg Leu Ser Asp 
                325                 330                 335     


Leu Arg Arg Ile Asn Glu Asp Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Thr Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 78
<211> 628
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 78
Val Glu Asp Glu Leu Lys Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly Asp Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Ala Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
    450                 455                 460                 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
465                 470                 475                 480 


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
                485                 490                 495     


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Asn Gly Gly Leu Pro Thr 
            500                 505                 510         


Arg Ala Glu Arg Glu Thr Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
        515                 520                 525             


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
    530                 535                 540                 


Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
545                 550                 555                 560 


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
                565                 570                 575     


Val Ile Gly Trp Asp Met Ala Ile Tyr Ala Val Ala Ile Pro Ser Thr 
            580                 585                 590         


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
        595                 600                 605             


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
    610                 615                 620                 


Asp Glu Leu Lys 
625             


<210> 79
<211> 617
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 79
Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro Gly 
1               5                   10                  15      


Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile Asn 
            20                  25                  30          


Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile Ile 
        35                  40                  45              


Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val Ser 
    50                  55                  60                  


Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu Asn 
65                  70                  75                  80  


Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala Ile 
                85                  90                  95      


Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys Ile 
            100                 105                 110         


Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro Lys 
        115                 120                 125             


Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr 
    130                 135                 140                 


Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala 
145                 150                 155                 160 


Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly Ser 
                165                 170                 175     


Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys Trp 
            180                 185                 190         


Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn Cys 
        195                 200                 205             


Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala Gly 
    210                 215                 220                 


Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro Val 
225                 230                 235                 240 


Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala 
                245                 250                 255     


Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg 
            260                 265                 270         


Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln 
        275                 280                 285             


Gln Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile 
    290                 295                 300                 


Asp Ser Ile Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala 
305                 310                 315                 320 


Glu Arg Leu Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met 
                325                 330                 335     


Val Ile Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val 
            340                 345                 350         


Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln 
        355                 360                 365             


Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys 
    370                 375                 380                 


Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser 
385                 390                 395                 400 


Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly 
                405                 410                 415     


Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu 
            420                 425                 430         


Thr Gln Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val 
        435                 440                 445             


Ala Ala Gln Ser Ile Val Asn Arg Ile Ser Pro Val Pro Arg Gly Ser 
    450                 455                 460                 


Asp Thr Glu Ser Glu Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr Asp 
465                 470                 475                 480 


Ala Ser Val Ala Tyr Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala Asp 
                485                 490                 495     


Gly Gly Gly Leu Thr Pro Ala Glu Arg Lys Ala Arg Gly Val Met Leu 
            500                 505                 510         


Arg Val Tyr Leu Pro Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile Asn 
        515                 520                 525             


Ala Asp Leu Glu Lys Glu Arg Asn Leu Val Glu Arg Val Ile Gly His 
    530                 535                 540                 


Pro Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu Glu 
545                 550                 555                 560 


Gly Ser Asp Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly Val 
                565                 570                 575     


Ala Ile Pro Ser Thr Ile Pro Gly Asn Ser Tyr Ala Gln Leu Pro Ile 
            580                 585                 590         


Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro 
        595                 600                 605             


Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
    610                 615         


<210> 80
<211> 605
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 80
Ser Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser 
1               5                   10                  15      


Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly 
            20                  25                  30          


Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg 
        35                  40                  45              


His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile 
    50                  55                  60                  


Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly 
65                  70                  75                  80  


Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala 
                85                  90                  95      


Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile 
            100                 105                 110         


Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
        115                 120                 125             


Gln Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu 
    130                 135                 140                 


His Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln 
145                 150                 155                 160 


Lys Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu 
                165                 170                 175     


Ala Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr 
            180                 185                 190         


Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu 
        195                 200                 205             


Thr Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu 
    210                 215                 220                 


Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met 
225                 230                 235                 240 


Glu Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu 
                245                 250                 255     


Ala Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala 
            260                 265                 270         


Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu 
        275                 280                 285             


Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu 
    290                 295                 300                 


Pro Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn 
305                 310                 315                 320 


Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr 
                325                 330                 335     


Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser 
            340                 345                 350         


Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala 
        355                 360                 365             


Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile 
    370                 375                 380                 


Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile 
385                 390                 395                 400 


Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr 
                405                 410                 415     


His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly 
            420                 425                 430         


Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val 
        435                 440                 445             


Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr 
    450                 455                 460                 


Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu 
465                 470                 475                 480 


Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg 
                485                 490                 495     


Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe 
            500                 505                 510         


Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln 
        515                 520                 525             


Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro 
    530                 535                 540                 


Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala 
545                 550                 555                 560 


Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu 
                565                 570                 575     


Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser 
            580                 585                 590         


Thr Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
        595                 600                 605 


<210> 81
<211> 594
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 81
Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Met Asp Glu Gly Lys Gly 
1               5                   10                  15      


Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg 
            20                  25                  30          


His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile 
        35                  40                  45              


Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly 
    50                  55                  60                  


Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala 
65                  70                  75                  80  


Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile 
                85                  90                  95      


Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
            100                 105                 110         


Gln Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu 
        115                 120                 125             


Gln Ser Ile Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser 
    130                 135                 140                 


Tyr Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His 
145                 150                 155                 160 


Trp His Thr Gly Leu Ala Leu Cys Trp Leu Val Pro Ile Asp Ala Ile 
                165                 170                 175     


Tyr Asn Tyr Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe 
            180                 185                 190         


Gly Gly Ser Tyr Glu Thr Val Ala Gly Thr Pro Lys Ala Ile Thr Val 
        195                 200                 205             


Lys Gln Gly Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser 
    210                 215                 220                 


Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys Gly Val 
225                 230                 235                 240 


Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp 
                245                 250                 255     


Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val 
            260                 265                 270         


Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn 
        275                 280                 285             


Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala Leu Arg 
    290                 295                 300                 


Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val 
305                 310                 315                 320 


Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr 
                325                 330                 335     


Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu 
            340                 345                 350         


Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln 
        355                 360                 365             


Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu 
    370                 375                 380                 


Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln 
385                 390                 395                 400 


Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe 
                405                 410                 415     


Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn 
            420                 425                 430         


Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys 
        435                 440                 445             


Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr 
    450                 455                 460                 


Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala 
465                 470                 475                 480 


Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala 
                485                 490                 495     


Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu 
            500                 505                 510         


Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu 
        515                 520                 525             


Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile 
    530                 535                 540                 


Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro 
545                 550                 555                 560 


Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys 
                565                 570                 575     


Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu 
            580                 585                 590         


Leu Lys 
        


<210> 82
<211> 588
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 82
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Met Asp Glu Gly Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Thr Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr 
                165                 170                 175     


Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His Trp 
            180                 185                 190         


His Thr Gly Leu Ala Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr 
        195                 200                 205             


Asn Tyr Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly 
    210                 215                 220                 


Gly Ser Tyr Glu Thr Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys 
225                 230                 235                 240 


Gln Gly Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys 
                245                 250                 255     


Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys Gly Val Pro 
            260                 265                 270         


Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp 
        275                 280                 285             


Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala 
    290                 295                 300                 


Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu 
305                 310                 315                 320 


Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg 
                325                 330                 335     


Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala 
            340                 345                 350         


Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro 
        355                 360                 365             


Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe 
    370                 375                 380                 


Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala 
385                 390                 395                 400 


Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn 
                405                 410                 415     


Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu 
            420                 425                 430         


Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val 
        435                 440                 445             


Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg 
    450                 455                 460                 


Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp 
465                 470                 475                 480 


Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala 
                485                 490                 495     


Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu 
            500                 505                 510         


Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser 
        515                 520                 525             


Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala 
545                 550                 555                 560 


Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Ile Ile Gly 
                565                 570                 575     


Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser 
            580                 585             


<210> 83
<211> 588
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 83
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Met Asp Glu Gly Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr 
                165                 170                 175     


Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His Trp 
            180                 185                 190         


His Thr Gly Leu Ala Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr 
        195                 200                 205             


Asn Tyr Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly 
    210                 215                 220                 


Gly Ser Tyr Glu Thr Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys 
225                 230                 235                 240 


Gln Gly Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys 
                245                 250                 255     


Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys Gly Val Pro 
            260                 265                 270         


Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp 
        275                 280                 285             


Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala 
    290                 295                 300                 


Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu 
305                 310                 315                 320 


Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln 
                325                 330                 335     


Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala 
            340                 345                 350         


Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro 
        355                 360                 365             


Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe 
    370                 375                 380                 


Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala 
385                 390                 395                 400 


Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn 
                405                 410                 415     


Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu 
            420                 425                 430         


Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val 
        435                 440                 445             


Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg 
    450                 455                 460                 


Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp 
465                 470                 475                 480 


Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala 
                485                 490                 495     


Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu 
            500                 505                 510         


Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser 
        515                 520                 525             


Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala 
545                 550                 555                 560 


Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly 
                565                 570                 575     


Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser 
            580                 585             


<210> 84
<211> 588
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 84
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Met Asp Glu Gly Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr 
                165                 170                 175     


Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His Trp 
            180                 185                 190         


His Thr Gly Leu Ala Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr 
        195                 200                 205             


Asn Tyr Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly 
    210                 215                 220                 


Gly Ser Tyr Glu Thr Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys 
225                 230                 235                 240 


Gln Gly Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys 
                245                 250                 255     


Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys Gly Val Pro 
            260                 265                 270         


Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp 
        275                 280                 285             


Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala 
    290                 295                 300                 


Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu 
305                 310                 315                 320 


Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln 
                325                 330                 335     


Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala 
            340                 345                 350         


Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro 
        355                 360                 365             


Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe 
    370                 375                 380                 


Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala 
385                 390                 395                 400 


Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn 
                405                 410                 415     


Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu 
            420                 425                 430         


Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val 
        435                 440                 445             


Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg 
    450                 455                 460                 


Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp 
465                 470                 475                 480 


Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala 
                485                 490                 495     


Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu 
            500                 505                 510         


Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser 
        515                 520                 525             


Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu 
    530                 535                 540                 


His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala 
545                 550                 555                 560 


Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly 
                565                 570                 575     


Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser 
            580                 585             


<210> 85
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 85
Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly 
1               5                   10                  15      


Glu Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg 
            20                  25                  30          


His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile 
        35                  40                  45              


Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly 
    50                  55                  60                  


Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala 
65                  70                  75                  80  


Ser Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile 
                85                  90                  95      


Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
            100                 105                 110         


Gln Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu 
        115                 120                 125             


Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His 
    130                 135                 140                 


Lys Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu 
145                 150                 155                 160 


Pro Lys Val Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr 
                165                 170                 175     


Gly Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro 
            180                 185                 190         


Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Ala Val Glu Gln 
        195                 200                 205             


Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His 
    210                 215                 220                 


Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro 
225                 230                 235                 240 


Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile 
                245                 250                 255     


Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser 
            260                 265                 270         


Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg 
        275                 280                 285             


Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr 
    290                 295                 300                 


Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His 
305                 310                 315                 320 


His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala 
                325                 330                 335     


Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala 
            340                 345                 350         


Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg 
        355                 360                 365             


Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr 
    370                 375                 380                 


Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg 
385                 390                 395                 400 


Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala 
                405                 410                 415     


Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr 
            420                 425                 430         


Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu 
        435                 440                 445             


Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Asn Gly Gly 
    450                 455                 460                 


Leu Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met Leu Arg Val 
465                 470                 475                 480 


Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro 
                485                 490                 495     


Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu 
            500                 505                 510         


Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu 
        515                 520                 525             


Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile Tyr Ala Val Ala Ile 
    530                 535                 540                 


Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu 
545                 550                 555                 560 


Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys 
                565                 570                 575     


Glu Gln Lys Asp Glu Leu Lys 
            580             


<210> 86
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 86
Met Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly 
1               5                   10                  15      


Glu Ser Ile Ile Thr Ile Gly Asp Phe Ala Thr Val Arg Ala Thr Arg 
            20                  25                  30          


His Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile 
        35                  40                  45              


Thr Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly 
    50                  55                  60                  


Glu Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala 
65                  70                  75                  80  


Ser Ile Lys Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile 
                85                  90                  95      


Glu Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu 
            100                 105                 110         


Gln Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu 
        115                 120                 125             


Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His 
    130                 135                 140                 


Lys Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser 
145                 150                 155                 160 


Pro Lys Val Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr 
                165                 170                 175     


Gly Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro 
            180                 185                 190         


Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln 
        195                 200                 205             


Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His 
    210                 215                 220                 


Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro 
225                 230                 235                 240 


Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile 
                245                 250                 255     


Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser 
            260                 265                 270         


Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg 
        275                 280                 285             


Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr 
    290                 295                 300                 


Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His 
305                 310                 315                 320 


His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala 
                325                 330                 335     


Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala 
            340                 345                 350         


Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg 
        355                 360                 365             


Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr 
    370                 375                 380                 


Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg 
385                 390                 395                 400 


Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala 
                405                 410                 415     


Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr 
            420                 425                 430         


Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu 
        435                 440                 445             


Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly 
    450                 455                 460                 


Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val 
465                 470                 475                 480 


Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro 
                485                 490                 495     


Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu 
            500                 505                 510         


Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Arg Val Asp Gly Glu 
        515                 520                 525             


Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile 
    530                 535                 540                 


Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu 
545                 550                 555                 560 


Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro Pro Tyr Lys 
                565                 570                 575     


Glu Arg Lys Asp Glu Leu Lys 
            580             


<210> 87
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 87
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Gln Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Thr Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Arg Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 88
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 88
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 89
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 89
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 90
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 90
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Ile Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Pro Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 91
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 91
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Thr Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Asn Gly Gly Leu Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Asp Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 92
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 92
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Ala Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Leu Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 93
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 93
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Met Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Tyr Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Arg Val Asp Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 94
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 94
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Asp Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Ala Val Ala Glu Arg Leu Ser Ala Ile Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asp Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 95
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 95
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Asp Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Ala Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asp Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Leu Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 96
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 96
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 97
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 97
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Thr Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 98
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 98
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Tyr Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 99
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 99
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Asn Gly Gly Leu Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 100
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 100
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Lys Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 101
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 101
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 102
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 102
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Ser Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Pro Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 103
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 103
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 104
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 104
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Glu Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 105
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 105
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Ala Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asp Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 106
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 106
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Pro Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Val Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 107
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 107
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Ala Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Arg Val Asp Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 108
<211> 583
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 108
Cys Ser Leu Thr Pro Glu Leu Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Asp Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Lys Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His 
145                 150                 155                 160 


Asn Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys 
                165                 170                 175     


Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala 
            180                 185                 190         


Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln 
        195                 200                 205             


Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr 
    210                 215                 220                 


Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln 
225                 230                 235                 240 


Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu 
                245                 250                 255     


Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala 
            260                 265                 270         


Arg Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr 
        275                 280                 285             


Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe 
    290                 295                 300                 


Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro 
305                 310                 315                 320 


Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn 
                325                 330                 335     


Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn 
            340                 345                 350         


Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala 
        355                 360                 365             


Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp 
    370                 375                 380                 


Lys Pro Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu 
385                 390                 395                 400 


Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr 
                405                 410                 415     


Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His 
            420                 425                 430         


Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr 
        435                 440                 445             


Asn His Val Ala Ala Gln Asn Ile Val Asn Arg Ile Ala Pro Val Pro 
    450                 455                 460                 


Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val 
465                 470                 475                 480 


Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly 
                485                 490                 495     


Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly 
            500                 505                 510         


Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr 
        515                 520                 525             


Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val 
    530                 535                 540                 


Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu 
545                 550                 555                 560 


Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile 
                565                 570                 575     


His Ala Val Ala Ile Pro Ser 
            580             


<210> 109
<211> 582
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 109
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Met Asp Glu Gly Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr 
                165                 170                 175     


Lys Ala Ala His Lys Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp 
            180                 185                 190         


Leu Thr Thr Leu Pro Lys Val Val Leu Cys Phe Phe Glu Asp Pro Glu 
        195                 200                 205             


Leu Cys Thr Tyr Gly Glu Asp Trp His Gly Gly Ala Tyr Lys Thr Val 
    210                 215                 220                 


Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys 
225                 230                 235                 240 


Thr Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala 
                245                 250                 255     


Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg 
            260                 265                 270         


Ser Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln 
        275                 280                 285             


Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser 
    290                 295                 300                 


His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu 
305                 310                 315                 320 


Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro 
                325                 330                 335     


Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp 
            340                 345                 350         


Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly 
        355                 360                 365             


Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys 
    370                 375                 380                 


Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser 
385                 390                 395                 400 


Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro 
                405                 410                 415     


Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln 
            420                 425                 430         


Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn 
        435                 440                 445             


His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg 
    450                 455                 460                 


Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala 
465                 470                 475                 480 


Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr 
                485                 490                 495     


Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val 
            500                 505                 510         


Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg 
        515                 520                 525             


Thr Asn Thr Leu Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile 
    530                 535                 540                 


Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser 
545                 550                 555                 560 


Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His 
                565                 570                 575     


Ala Val Ala Ile Pro Ser 
            580         


<210> 110
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 110
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro 
            180                 185                 190         


Lys Val Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Asp Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 111
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 111
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro 
            180                 185                 190         


Lys Val Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Asp Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Ala Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 112
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 112
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Lys Val Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 113
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 113
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Lys Val Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Ala Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Asp Leu Arg Arg Ile Asn Glu Asp Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Thr Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 114
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 114
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Lys Val Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Asn Gly Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile Tyr Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 115
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 115
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Ile Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Phe Thr Thr Ser Pro 
            180                 185                 190         


Lys Val Thr Leu Cys Phe Tyr Glu Asp Pro Ala Gln Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Ile Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Asp Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Gln Glu Thr Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 116
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 116
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Lys Val Val Leu Cys Phe Tyr Glu Glu Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Glu Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Gly 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 117
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 117
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Lys Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Lys Val Val Leu Cys Phe Tyr Glu Glu Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Glu Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Glu 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 118
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 118
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Ile Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Lys Val Val Leu Cys Phe Tyr Glu Asp Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val 
        275                 280                 285             


Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Val Val Ile Thr Pro Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Asp Ala Thr His Gln Ala Leu Thr Arg Glu 
            420                 425                 430         


Asp Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu 
    450                 455                 460                 


Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val 
465                 470                 475                 480 


Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu 
                485                 490                 495     


Pro Thr Arg Ala Glu Arg Glu Thr Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu 
        515                 520                 525             


Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp 
545                 550                 555                 560 


Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 119
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 119
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Glu Val Val Leu Cys Phe Phe Glu Asp Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln Gln Ile Val 
        275                 280                 285             


Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile Asp Ser Ile 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Ile Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Gln Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Asn Arg Ile Ser Pro Val Pro Arg Gly Ser Asp Thr Glu 
    450                 455                 460                 


Ser Glu Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr Asp Ala Ser Val 
465                 470                 475                 480 


Ala Tyr Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala Asp Gly Gly Gly 
                485                 490                 495     


Leu Thr Pro Ala Glu Arg Lys Ala Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Leu Pro Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile Asn Ala Asp Leu 
        515                 520                 525             


Glu Lys Glu Arg Asn Leu Val Glu Arg Val Ile Gly His Pro Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu Glu Gly Ser Asp 
545                 550                 555                 560 


Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 120
<211> 577
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 120
Cys Ser Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser 
1               5                   10                  15      


Ile Pro Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met 
            20                  25                  30          


Thr Ile Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu 
        35                  40                  45              


Ser Ile Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His 
    50                  55                  60                  


Tyr Val Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr 
65                  70                  75                  80  


Thr Glu Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu 
                85                  90                  95      


Phe Ala Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser 
            100                 105                 110         


Ile Lys Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu 
        115                 120                 125             


Val Pro Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln 
    130                 135                 140                 


Trp Glu Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln 
145                 150                 155                 160 


Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys 
                165                 170                 175     


Asn Gly Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro 
            180                 185                 190         


Glu Val Val Leu Cys Phe Phe Glu Asp Pro Glu Leu Cys Thr Tyr Gly 
        195                 200                 205             


Asp Asp Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Lys 
    210                 215                 220                 


Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg 
225                 230                 235                 240 


Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg 
                245                 250                 255     


Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg 
            260                 265                 270         


Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala Gln Gln Ile Val 
        275                 280                 285             


Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr His Ile Asp Ser Ile 
    290                 295                 300                 


Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu Val Ala Glu Arg Leu 
305                 310                 315                 320 


Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val Ile Gln 
                325                 330                 335     


Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His 
            340                 345                 350         


Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Ser Ala Gln Ala Ala Asp 
        355                 360                 365             


Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser 
    370                 375                 380                 


Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser 
385                 390                 395                 400 


Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Gln Gln Gly Val Thr Asn 
                405                 410                 415     


Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Gln Glu 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Asn Arg Ile Ser Pro Val Pro Arg Gly Ser Asp Thr Glu 
    450                 455                 460                 


Ser Glu Arg Ala Trp Gly Gly Leu Tyr Val Ser Thr Asp Ala Ser Val 
465                 470                 475                 480 


Ala Tyr Gly Tyr Ala Arg Ile Gln Glu Gly Thr Ala Asp Gly Gly Gly 
                485                 490                 495     


Leu Thr Pro Ala Glu Arg Lys Ala Arg Gly Val Met Leu Arg Val Tyr 
            500                 505                 510         


Leu Pro Gln Ala Ser Leu Glu Arg Phe Tyr Arg Ile Asn Ala Asp Leu 
        515                 520                 525             


Glu Lys Glu Arg Asn Leu Val Glu Arg Val Ile Gly His Pro Leu Pro 
    530                 535                 540                 


Leu Arg Asn Glu Ala Phe Thr Gly Thr Asp Ala Glu Glu Gly Ser Asp 
545                 550                 555                 560 


Glu Thr Ala Ile Gly Trp Asp Met Ala Ile His Gly Val Ala Ile Pro 
                565                 570                 575     


Ser 
    


<210> 121
<211> 531
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 121
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Gln Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Lys Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val 
    530     


<210> 122
<211> 491
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 122
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Glu Lys Asp Gly 
            180                 185                 190         


Ala Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Leu Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Met Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Gly 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Gln Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Thr Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Ile Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr Glu His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Leu Cys Pro Asp Ala Asp Gly Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Lys His Gln Thr 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Thr Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Lys Glu Glu Glu Trp Gly Gly 
                485                 490     


<210> 123
<211> 491
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 123
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Glu Lys Asp Gly 
            180                 185                 190         


Ala Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Leu Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Met Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Gly 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Gln Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Thr Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Ile Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr Glu His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Glu Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Lys His Gln Thr 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Ser Ile Val Asn Arg Ile Thr Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Lys Glu Glu Glu Trp Gly Gly 
                485                 490     


<210> 124
<211> 488
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 124
Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys Thr Gln 
1               5                   10                  15      


Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile Ala Ile 
            20                  25                  30          


Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly Ser Arg 
        35                  40                  45              


His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys Trp Leu 
    50                  55                  60                  


Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn Cys Thr 
65                  70                  75                  80  


Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala Gly Thr 
                85                  90                  95      


Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro Val Glu 
            100                 105                 110         


Gln Arg Ile His Phe Ser Asn Gly Asn Ala Met Ser Ala Leu Ala Ala 
        115                 120                 125             


His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys 
    130                 135                 140                 


Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn 
145                 150                 155                 160 


Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp 
                165                 170                 175     


Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu 
            180                 185                 190         


Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly Met Val 
        195                 200                 205             


Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr 
    210                 215                 220                 


His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala 
225                 230                 235                 240 


Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val 
                245                 250                 255     


Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly 
            260                 265                 270         


Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val 
        275                 280                 285             


Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr 
    290                 295                 300                 


Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala 
305                 310                 315                 320 


Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn 
                325                 330                 335     


Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala 
            340                 345                 350         


Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr 
        355                 360                 365             


Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met Leu Arg 
    370                 375                 380                 


Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr 
385                 390                 395                 400 


Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly His Ser 
                405                 410                 415     


Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly 
            420                 425                 430         


Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala 
        435                 440                 445             


Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp 
    450                 455                 460                 


Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr 
465                 470                 475                 480 


Lys Glu Arg Lys Asp Glu Leu Lys 
                485             


<210> 125
<211> 459
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 125
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Lys Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala His Lys Asn Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala Asn Trp Leu Thr Thr Leu Pro Lys Val 
        195                 200                 205             


Val Leu Cys Phe Tyr Glu Glu Pro Glu Leu Cys Thr Tyr Gly Glu Asp 
    210                 215                 220                 


Trp His Gly Gly Ala Tyr Lys Thr Val Ala Gly Thr Pro Glu Ala Ile 
225                 230                 235                 240 


Thr Val Lys Gln Gly Ile Glu Gln Lys Thr Val Glu Gln Arg Ile His 
                245                 250                 255     


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
            260                 265                 270         


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
        275                 280                 285             


Gln Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
    290                 295                 300                 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
305                 310                 315                 320 


Leu Asn Leu Asp Glu Gln Glu Pro Ala Val Ala Glu Arg Leu Ser Ala 
                325                 330                 335     


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
            340                 345                 350         


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
        355                 360                 365             


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
    370                 375                 380                 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn 
385                 390                 395                 400 


Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
                405                 410                 415     


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
            420                 425                 430         


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
        435                 440                 445             


Val Phe Val Gly Tyr His Gly Thr Asn His Val 
    450                 455                 


<210> 126
<211> 415
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 126
Val Glu Glu Ala Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Gly Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Ser Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Phe Asn Arg Lys Glu Ser Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Ile Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Asn Ala 
    290                 295                 300                 


Gln Gln Ile Val Ser Leu Phe Leu Ala Thr Arg Ile Leu Phe Thr His 
305                 310                 315                 320 


Ile Asp Ser Ile Phe Thr Leu Asn Leu Asp Gly Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Asp Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Ile Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Ser Asp Gln Ala Asn Ile Asn Ile Glu Ser 
                405                 410                 415 


<210> 127
<211> 318
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 127
Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu His Glu Gln 
1               5                   10                  15      


Glu Pro Ala Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu 
            20                  25                  30          


Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile 
        35                  40                  45              


Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr 
    50                  55                  60                  


Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp 
65                  70                  75                  80  


Ala Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn 
                85                  90                  95      


Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val 
            100                 105                 110         


Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala 
        115                 120                 125             


Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His 
    130                 135                 140                 


Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro 
145                 150                 155                 160 


Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu 
                165                 170                 175     


Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys 
            180                 185                 190         


Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala 
        195                 200                 205             


Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg 
    210                 215                 220                 


Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr 
225                 230                 235                 240 


Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly 
                245                 250                 255     


Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met 
            260                 265                 270         


Ala Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr 
        275                 280                 285             


Glu Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile 
    290                 295                 300                 


Ser Ala Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
305                 310                 315             


<210> 128
<211> 208
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 128
Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu 
1               5                   10                  15      


Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly 
            20                  25                  30          


Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile 
        35                  40                  45              


Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly 
    50                  55                  60                  


Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg 
65                  70                  75                  80  


Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg 
                85                  90                  95      


Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu 
            100                 105                 110         


Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His 
        115                 120                 125             


Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe 
    130                 135                 140                 


Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp 
145                 150                 155                 160 


Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn 
                165                 170                 175     


Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln 
            180                 185                 190         


Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
        195                 200                 205             


<210> 129
<211> 207
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 129
Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu 
1               5                   10                  15      


Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly 
            20                  25                  30          


Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile 
        35                  40                  45              


Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly 
    50                  55                  60                  


Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg 
65                  70                  75                  80  


Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg 
                85                  90                  95      


Asp Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu 
            100                 105                 110         


Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His 
        115                 120                 125             


Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe 
    130                 135                 140                 


Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp 
145                 150                 155                 160 


Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn 
                165                 170                 175     


Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln 
            180                 185                 190         


Ser Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu 
        195                 200                 205         


<210> 130
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 130
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 131
<211> 644
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 131
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Lys Gln Ser Ile Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser 
            180                 185                 190         


Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp 
        195                 200                 205             


Ala His Trp His Thr Gly Leu Ala Leu Cys Trp Leu Val Pro Ile Asp 
    210                 215                 220                 


Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn 
225                 230                 235                 240 


Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala Gly Thr Pro Lys Ala Ile 
                245                 250                 255     


Thr Val Lys Gln Gly Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His 
            260                 265                 270         


Phe Ser Lys Lys Asn Ala Met Glu Ala Leu Ala Ala His Arg Val Cys 
        275                 280                 285             


Gly Val Pro Leu Glu Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu 
    290                 295                 300                 


Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu 
305                 310                 315                 320 


Phe Val Ala Thr Arg Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr 
                325                 330                 335     


Leu Asn Leu Asp Glu Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala 
            340                 345                 350         


Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu 
        355                 360                 365             


Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly 
    370                 375                 380                 


Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu 
385                 390                 395                 400 


Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro Cys Val Ala Ser Asn Asn 
                405                 410                 415     


Asp Gln Ala Asn Ile Asn Val Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
            420                 425                 430         


Pro Glu Asn Arg Ala Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr 
        435                 440                 445             


Tyr Gln Glu Leu Glu Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr 
    450                 455                 460                 


Val Phe Val Gly Tyr His Gly Thr Asn His Val Ala Ala Gln Thr Ile 
465                 470                 475                 480 


Val Asn Arg Ile Ala Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu 
                485                 490                 495     


Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr His Ala Glu Val Ala His 
            500                 505                 510         


Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr 
        515                 520                 525             


Arg Ala Glu Arg Glu Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro 
    530                 535                 540                 


Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn 
545                 550                 555                 560 


Ala Glu Arg His Ile Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg 
                565                 570                 575     


Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr 
            580                 585                 590         


Val Ile Gly Trp Asp Met Ala Ile His Ala Val Ala Ile Pro Ser Thr 
        595                 600                 605             


Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val 
    610                 615                 620                 


Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys 
625                 630                 635                 640 


Asp Glu Leu Lys 
                


<210> 132
<211> 639
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 132
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Met Asp Glu Gly Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ala Val Thr Arg Pro Glu Gln Ser Ile 
                165                 170                 175     


Ala Lys Gln Ser Ile Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala 
            180                 185                 190         


Ala Gln Lys Glu Gly Ser Arg His Lys Arg Trp Ala His Trp His Thr 
        195                 200                 205             


Gly Leu Ala Leu Cys Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr 
    210                 215                 220                 


Ile Thr Gln Gln Asn Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser 
225                 230                 235                 240 


Tyr Glu Thr Val Ala Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly 
                245                 250                 255     


Ile Glu Gln Lys Pro Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn 
            260                 265                 270         


Ala Met Glu Ala Leu Ala Ala His Arg Val Cys Gly Val Pro Leu Glu 
        275                 280                 285             


Thr Leu Ala Arg Ser Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser 
    290                 295                 300                 


Cys Ala Tyr Gln Ala Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg 
305                 310                 315                 320 


Ile Leu Phe Ser His Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu 
                325                 330                 335     


Gln Glu Pro Glu Val Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn 
            340                 345                 350         


Glu Asn Asn Pro Gly Met Val Thr Gln Val Leu Thr Val Ala Arg Gln 
        355                 360                 365             


Ile Tyr Asn Asp Tyr Val Thr His His Pro Gly Leu Thr Pro Glu Gln 
    370                 375                 380                 


Thr Ser Ala Gly Ala Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro 
385                 390                 395                 400 


Asp Ala Asp Lys Ser Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile 
                405                 410                 415     


Asn Ile Glu Ser Arg Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala 
            420                 425                 430         


Val Ile Thr Pro Gln Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu 
        435                 440                 445             


Ala Thr His Gln Ala Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr 
    450                 455                 460                 


His Gly Thr Asn His Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala 
465                 470                 475                 480 


Pro Val Pro Arg Gly Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly 
                485                 490                 495     


Leu Tyr Val Ala Thr His Ala Glu Val Ala His Gly Tyr Ala Arg Ile 
            500                 505                 510         


Lys Glu Gly Thr Gly Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp 
        515                 520                 525             


Ala Arg Gly Val Met Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu 
    530                 535                 540                 


Arg Phe Tyr Arg Thr Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile 
545                 550                 555                 560 


Thr Gln Val Ile Gly His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr 
                565                 570                 575     


Gly Pro Glu Ser Ala Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp 
            580                 585                 590         


Met Ala Ile His Ala Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala 
        595                 600                 605             


Tyr Glu Glu Leu Ala Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser 
    610                 615                 620                 


Ile Ser Thr Lys Pro Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 635                 


<210> 133
<211> 639
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 133
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Arg Leu Thr 
        595                 600                 605             


Pro Ala Glu Glu Ala Val Val Lys Glu Ala Ile Ala Lys Glu Gln Ser 
    610                 615                 620                 


Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 635                 


<210> 134
<211> 639
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 134
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile His Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Arg Leu Thr 
        595                 600                 605             


Pro Ala Glu Glu Ala Val Val Lys Glu Ala Ile Ala Lys Glu Gln Ser 
    610                 615                 620                 


Ile Ser Ala Lys Pro Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 635                 


<210> 135
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 135
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Gln Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Lys Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 136
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 136
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 137
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 137
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Met Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Val Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Gly Asn Ala Met Ser Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Asp Leu Arg Arg Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ser Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 138
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 138
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Thr Asp Asp Leu Ser Cys Val Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Lys Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 139
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 139
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile His Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 140
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 140
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asp Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 141
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 141
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Ile Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 142
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 142
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Ile Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 143
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 143
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Met Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Ile Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Glu Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Arg His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Gln Lys Asp Glu Leu Lys 
625                 630                 


<210> 144
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 144
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Leu Lys Lys Gly Thr Gly 
            500                 505                 510         


Asn Ala Glu Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr His Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Arg Val 
                565                 570                 575     


Asp Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Val Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Glu Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 145
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 145
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Lys 
145                 150                 155                 160 


Thr Gln Gly Asn Val Phe Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Glu Val 
                325                 330                 335     


Thr Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Pro 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile His Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Thr Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 146
<211> 634
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      Cholix sequence

<400> 146
Val Glu Asp Glu Leu Asn Ile Phe Asp Glu Cys Arg Ser Pro Cys Ser 
1               5                   10                  15      


Leu Thr Pro Glu Pro Gly Lys Pro Ile Gln Ser Lys Leu Ser Ile Pro 
            20                  25                  30          


Ser Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Lys Asp Glu Asp Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Ile Gly Glu Phe Ala Thr Val Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Asn Gln Asp Ala Pro Phe Gly Val Ile Asn Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Thr Tyr Ser Tyr Asn Arg Lys Glu Gly Glu Phe Ala 
            100                 105                 110         


Ile Asn Trp Leu Val Pro Ile Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Val Asp Glu Leu Asp Gln Gln Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Glu 
145                 150                 155                 160 


Asn Gln Gly Asn Val Ser Phe Ser Val Thr Arg Pro Glu His Asn Ile 
                165                 170                 175     


Ala Ile Ser Trp Pro Ser Val Ser Tyr Lys Ala Ala Gln Lys Glu Gly 
            180                 185                 190         


Ser Arg His Lys Arg Trp Ala His Trp His Thr Gly Leu Ala Leu Cys 
        195                 200                 205             


Trp Leu Val Pro Ile Asp Ala Ile Tyr Asn Tyr Ile Thr Gln Gln Asn 
    210                 215                 220                 


Cys Thr Leu Gly Asp Asn Trp Phe Gly Gly Ser Tyr Glu Thr Val Ala 
225                 230                 235                 240 


Gly Thr Pro Lys Ala Ile Thr Val Lys Gln Gly Ile Glu Gln Lys Pro 
                245                 250                 255     


Val Glu Gln Arg Ile His Phe Ser Lys Lys Asn Ala Met Glu Ala Leu 
            260                 265                 270         


Ala Ala His Arg Val Cys Gly Val Pro Leu Glu Thr Leu Ala Arg Ser 
        275                 280                 285             


Arg Lys Pro Arg Asp Leu Pro Asp Asp Leu Ser Cys Ala Tyr Gln Ala 
    290                 295                 300                 


Gln Asn Ile Val Ser Leu Phe Val Ala Thr Arg Ile Leu Phe Ser His 
305                 310                 315                 320 


Leu Asp Ser Val Phe Thr Leu Asn Leu Asp Glu Gln Glu Pro Ala Val 
                325                 330                 335     


Ala Glu Arg Leu Ser Ala Leu Arg Gln Ile Asn Glu Asn Asn Pro Gly 
            340                 345                 350         


Met Val Thr Gln Val Leu Thr Val Ala Arg Gln Ile Tyr Asn Asp Tyr 
        355                 360                 365             


Val Thr His His Pro Gly Leu Thr Pro Glu Gln Thr Ser Ala Gly Ala 
    370                 375                 380                 


Gln Ala Ala Asp Ile Leu Ser Leu Phe Cys Pro Asp Ala Asp Lys Ser 
385                 390                 395                 400 


Cys Val Ala Ser Asn Asn Asp Gln Ala Asn Ile Asn Ile Glu Ser Arg 
                405                 410                 415     


Ser Gly Arg Ser Tyr Leu Pro Glu Asn Arg Ala Val Ile Thr Pro Gln 
            420                 425                 430         


Gly Val Thr Asn Trp Thr Tyr Gln Glu Leu Glu Ala Thr His Gln Ala 
        435                 440                 445             


Leu Thr Arg Glu Gly Tyr Val Phe Val Gly Tyr His Gly Thr Asn His 
    450                 455                 460                 


Val Ala Ala Gln Thr Ile Val Asn Arg Ile Ala Pro Val Pro Arg Gly 
465                 470                 475                 480 


Asn Asn Thr Glu Asn Glu Glu Lys Trp Gly Gly Leu Tyr Val Ala Thr 
                485                 490                 495     


His Ala Glu Val Ala His Gly Tyr Ala Arg Ile Lys Glu Gly Thr Gly 
            500                 505                 510         


Glu Tyr Gly Leu Pro Thr Arg Ala Glu Arg Asp Ala Arg Gly Val Met 
        515                 520                 525             


Leu Arg Val Tyr Ile Pro Arg Ala Ser Leu Glu Arg Phe Tyr Arg Thr 
    530                 535                 540                 


Asn Thr Pro Leu Glu Asn Ala Glu Glu His Ile Thr Gln Val Ile Gly 
545                 550                 555                 560 


His Ser Leu Pro Leu Arg Asn Glu Ala Phe Thr Gly Pro Glu Ser Ala 
                565                 570                 575     


Gly Gly Glu Asp Glu Thr Val Ile Gly Trp Asp Met Ala Ile His Ala 
            580                 585                 590         


Val Ala Ile Pro Ser Thr Ile Pro Gly Asn Ala Tyr Glu Glu Leu Ala 
        595                 600                 605             


Ile Asp Glu Glu Ala Val Ala Lys Glu Gln Ser Ile Ser Ala Lys Pro 
    610                 615                 620                 


Pro Tyr Lys Glu Arg Lys Asp Glu Leu Lys 
625                 630                 


<210> 147
<211> 649
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V or L

<220>
<221> MOD_RES
<222> (3)..(3)
<223> E or D

<220>
<221> MOD_RES
<222> (4)..(4)
<223> A or E

<220>
<221> MOD_RES
<222> (6)..(6)
<223> N or K

<220>
<221> MOD_RES
<222> (16)..(16)
<223> S or L

<220>
<221> MOD_RES
<222> (21)..(21)
<223> P or L

<220>
<221> MOD_RES
<222> (24)..(24)
<223> P or Q

<220>
<221> MOD_RES
<222> (30)..(30)
<223> S or F

<220>
<221> MOD_RES
<222> (33)..(33)
<223> S or G

<220>
<221> MOD_RES
<222> (56)..(56)
<223> K or M

<220>
<221> MOD_RES
<222> (59)..(59)
<223> D or G

<220>
<221> MOD_RES
<222> (67)..(67)
<223> I or F

<220>
<221> MOD_RES
<222> (73)..(73)
<223> V or I

<220>
<221> MOD_RES
<222> (81)..(81)
<223> N or S

<220>
<221> MOD_RES
<222> (90)..(90)
<223> H or N

<220>
<221> MOD_RES
<222> (101)..(101)
<223> T or M

<220>
<221> MOD_RES
<222> (104)..(104)
<223> Y or F

<220>
<221> MOD_RES
<222> (108)..(108)
<223> E or D

<220>
<221> MOD_RES
<222> (109)..(109)
<223> G or S

<220>
<221> MOD_RES
<222> (112)..(112)
<223> A or T

<220>
<221> MOD_RES
<222> (114)..(114)
<223> N or H

<220>
<221> MOD_RES
<222> (118)..(118)
<223> P or I

<220>
<221> MOD_RES
<222> (119)..(119)
<223> I or P

<220>
<221> MOD_RES
<222> (131)..(131)
<223> V or I

<220>
<221> MOD_RES
<222> (134)..(134)
<223> L or I

<220>
<221> MOD_RES
<222> (137)..(137)
<223> Q or K

<220>
<221> MOD_RES
<222> (160)..(160)
<223> K or E

<220>
<221> MOD_RES
<222> (161)..(161)
<223> T or N

<220>
<221> MOD_RES
<222> (166)..(166)
<223> S or F

<220>
<221> MOD_RES
<222> (168)..(168)
<223> S or A

<220>
<221> MOD_RES
<222> (174)..(174)
<223> H or Q

<220>
<221> MISC_FEATURE
<222> (175)..(185)
<223> This region may encompass "N", "S", "SIAKQS", or "SIAKQSIAKQS"

<220>
<221> MOD_RES
<222> (196)..(196)
<223> K or N

<220>
<221> MOD_RES
<222> (199)..(199)
<223> Q, E, or H

<220>
<221> MOD_RES
<222> (201)..(201)
<223> E, N, or D

<220>
<221> MOD_RES
<222> (203)..(203)
<223> S or A

<220>
<221> MOD_RES
<222> (210)..(210)
<223> H or N

<220>
<221> MOD_RES
<222> (212)..(212)
<223> H, L, F, or R

<220>
<221> MOD_RES
<222> (214)..(214)
<223> G or T

<220>
<221> MOD_RES
<222> (215)..(215)
<223> L or S

<220>
<221> MOD_RES
<222> (216)..(216)
<223> A or P

<220>
<221> MOD_RES
<222> (217)..(217)
<223> L, E, or K

<220>
<221> MOD_RES
<222> (218)..(218)
<223> C or V

<220>
<221> MOD_RES
<222> (219)..(219)
<223> W, V, or T

<220>
<221> MOD_RES
<222> (221)..(221)
<223> V or not present

<220>
<221> MOD_RES
<222> (222)..(222)
<223> P or not present

<220>
<221> MOD_RES
<222> (223)..(223)
<223> M, I, L, or not present

<220>
<221> MOD_RES
<222> (224)..(224)
<223> D or not present

<220>
<221> MOD_RES
<222> (225)..(225)
<223> A or not present

<220>
<221> MOD_RES
<222> (226)..(226)
<223> I or not present

<220>
<221> MOD_RES
<222> (227)..(227)
<223> Y or C

<220>
<221> MOD_RES
<222> (228)..(228)
<223> N or F

<220>
<221> MOD_RES
<222> (229)..(229)
<223> Y or F

<220>
<221> MOD_RES
<222> (230)..(230)
<223> I or E

<220>
<221> MOD_RES
<222> (231)..(231)
<223> T or D

<220>
<221> MOD_RES
<222> (232)..(232)
<223> Q or P

<220>
<221> MOD_RES
<222> (233)..(233)
<223> Q, E, or A

<220>
<221> MOD_RES
<222> (234)..(234)
<223> N, L, or Q

<220>
<221> MOD_RES
<222> (237)..(237)
<223> L or Y

<220>
<221> MOD_RES
<222> (239)..(239)
<223> D or E

<220>
<221> MOD_RES
<222> (240)..(240)
<223> N or D

<220>
<221> MOD_RES
<222> (242)..(242)
<223> F, H, or Y

<220>
<221> MOD_RES
<222> (245)..(245)
<223> S or A

<220>
<221> MOD_RES
<222> (247)..(247)
<223> E or K

<220>
<221> MOD_RES
<222> (252)..(252)
<223> T or I

<220>
<221> MOD_RES
<222> (254)..(254)
<223> K, E, or G

<220>
<221> MOD_RES
<222> (255)..(255)
<223> V or A

<220>
<221> MOD_RES
<222> (257)..(257)
<223> T or M

<220>
<221> MOD_RES
<222> (262)..(262)
<223> I or M

<220>
<221> MOD_RES
<222> (266)..(266)
<223> P, T, or A

<220>
<221> MOD_RES
<222> (275)..(275)
<223> K, Q, or N

<220>
<221> MOD_RES
<222> (276)..(276)
<223> G or K

<220>
<221> MOD_RES
<222> (279)..(279)
<223> M or I

<220>
<221> MOD_RES
<222> (280)..(280)
<223> S or E

<220>
<221> MOD_RES
<222> (281)..(281)
<223> A or T

<220>
<221> MOD_RES
<222> (298)..(298)
<223> S or G

<220>
<221> MOD_RES
<222> (303)..(303)
<223> D or Y

<220>
<221> MOD_RES
<222> (305)..(305)
<223> T, P, or Q

<220>
<221> MOD_RES
<222> (309)..(309)
<223> S or Q

<220>
<221> MOD_RES
<222> (311)..(311)
<223> A or V

<220>
<221> MOD_RES
<222> (313)..(313)
<223> Q or N

<220>
<221> MOD_RES
<222> (316)..(316)
<223> N or Q

<220>
<221> MOD_RES
<222> (322)..(322)
<223> V or L

<220>
<221> MOD_RES
<222> (326)..(326)
<223> I or M

<220>
<221> MOD_RES
<222> (329)..(329)
<223> S or T

<220>
<221> MOD_RES
<222> (331)..(331)
<223> L or I

<220>
<221> MOD_RES
<222> (334)..(334)
<223> V or I

<220>
<221> MOD_RES
<222> (340)..(340)
<223> D, E, or H

<220>
<221> MOD_RES
<222> (341)..(341)
<223> E or G

<220>
<221> MOD_RES
<222> (343)..(343)
<223> E or A

<220>
<221> MOD_RES
<222> (345)..(345)
<223> E or A

<220>
<221> MOD_RES
<222> (347)..(347)
<223> A or T

<220>
<221> MOD_RES
<222> (351)..(351)
<223> S, D, or T

<220>
<221> MOD_RES
<222> (352)..(352)
<223> D or A

<220>
<221> MOD_RES
<222> (353)..(353)
<223> L or I

<220>
<221> MOD_RES
<222> (355)..(355)
<223> R or Q

<220>
<221> MOD_RES
<222> (359)..(359)
<223> N or D

<220>
<221> MOD_RES
<222> (363)..(363)
<223> M or V

<220>
<221> MOD_RES
<222> (365)..(365)
<223> T or I

<220>
<221> MOD_RES
<222> (370)..(370)
<223> V or I

<220>
<221> MOD_RES
<222> (381)..(381)
<223> H or E

<220>
<221> MOD_RES
<222> (384)..(384)
<223> G or L

<220>
<221> MOD_RES
<222> (386)..(386)
<223> T or I

<220>
<221> MOD_RES
<222> (393)..(393)
<223> G or S

<220>
<221> MOD_RES
<222> (403)..(403)
<223> F or L

<220>
<221> MOD_RES
<222> (404)..(404)
<223> C or Y

<220>
<221> MOD_RES
<222> (407)..(407)
<223> A or T

<220>
<221> MOD_RES
<222> (409)..(409)
<223> K, E, or G

<220>
<221> MOD_RES
<222> (410)..(410)
<223> S, P, or H

<220>
<221> MOD_RES
<222> (414)..(414)
<223> S or L

<220>
<221> MOD_RES
<222> (415)..(415)
<223> N or D

<220>
<221> MOD_RES
<222> (416)..(416)
<223> N or S

<220>
<221> MOD_RES
<222> (423)..(423)
<223> I or V

<220>
<221> MOD_RES
<222> (433)..(433)
<223> P or L

<220>
<221> MOD_RES
<222> (441)..(441)
<223> P or Q

<220>
<221> MOD_RES
<222> (453)..(453)
<223> E or D

<220>
<221> MOD_RES
<222> (454)..(454)
<223> A or T

<220>
<221> MOD_RES
<222> (455)..(455)
<223> T or K

<220>
<221> MOD_RES
<222> (458)..(458)
<223> A or T

<220>
<221> MOD_RES
<222> (461)..(461)
<223> R or Q

<220>
<221> MOD_RES
<222> (463)..(463)
<223> G or D

<220>
<221> MOD_RES
<222> (475)..(475)
<223> V or A

<220>
<221> MOD_RES
<222> (479)..(479)
<223> T, S, or N

<220>
<221> MOD_RES
<222> (485)..(485)
<223> A, S, or T

<220>
<221> MOD_RES
<222> (491)..(491)
<223> N or S

<220>
<221> MOD_RES
<222> (492)..(492)
<223> N or D

<220>
<221> MOD_RES
<222> (495)..(495)
<223> N, S, or K

<220>
<221> MOD_RES
<222> (497)..(497)
<223> E, R, or K

<220>
<221> MOD_RES
<222> (498)..(498)
<223> K, A, or E

<220>
<221> MOD_RES
<222> (502)..(502)
<223> L or V

<220>
<221> MOD_RES
<222> (505)..(505)
<223> A or S

<220>
<221> MOD_RES
<222> (507)..(507)
<223> H or D

<220>
<221> MOD_RES
<222> (509)..(509)
<223> E or S

<220>
<221> MOD_RES
<222> (510)..(510)
<223> V or L

<220>
<221> MOD_RES
<222> (511)..(511)
<223> A or N

<220>
<221> MOD_RES
<222> (512)..(512)
<223> H or Y

<220>
<221> MOD_RES
<222> (513)..(513)
<223> G or R

<220>
<221> MOD_RES
<222> (515)..(515)
<223> A or T

<220>
<221> MOD_RES
<222> (517)..(517)
<223> I or L

<220>
<221> MOD_RES
<222> (518)..(518)
<223> K or Q

<220>
<221> MOD_RES
<222> (519)..(519)
<223> E or K

<220>
<221> MOD_RES
<222> (522)..(522)
<223> G or A

<220>
<221> MOD_RES
<222> (523)..(523)
<223> E, D, or N

<220>
<221> MOD_RES
<222> (524)..(524)
<223> Y, G, A, or N

<220>
<221> MOD_RES
<222> (525)..(525)
<223> G or E

<220>
<221> MOD_RES
<222> (526)..(526)
<223> L or G

<220>
<221> MOD_RES
<222> (527)..(527)
<223> P or L

<220>
<221> MOD_RES
<222> (529)..(529)
<223> R, P, or T

<220>
<221> MOD_RES
<222> (530)..(530)
<223> A or E

<220>
<221> MOD_RES
<222> (531)..(531)
<223> E or K

<220>
<221> MOD_RES
<222> (532)..(532)
<223> R, Q, or K

<220>
<221> MOD_RES
<222> (533)..(533)
<223> D, K, or E

<220>
<221> MOD_RES
<222> (534)..(534)
<223> A, T, or S

<220>
<221> MOD_RES
<222> (540)..(540)
<223> R or K

<220>
<221> MOD_RES
<222> (543)..(543)
<223> I or L

<220>
<221> MOD_RES
<222> (544)..(544)
<223> P or H

<220>
<221> MOD_RES
<222> (545)..(545)
<223> R or Q

<220>
<221> MOD_RES
<222> (554)..(554)
<223> T or I

<220>
<221> MOD_RES
<222> (556)..(556)
<223> T, A, or I

<220>
<221> MOD_RES
<222> (557)..(557)
<223> P or D

<220>
<221> MOD_RES
<222> (560)..(560)
<223> N or K

<220>
<221> MOD_RES
<222> (561)..(561)
<223> A or E

<220>
<221> MOD_RES
<222> (562)..(562)
<223> E, R, or D

<220>
<221> MOD_RES
<222> (563)..(563)
<223> E, N, or R

<220>
<221> MOD_RES
<222> (564)..(564)
<223> H or L

<220>
<221> MOD_RES
<222> (565)..(565)
<223> I or V

<220>
<221> MOD_RES
<222> (566)..(566)
<223> T or E

<220>
<221> MOD_RES
<222> (567)..(567)
<223> Q, R, H, or D

<220>
<221> MOD_RES
<222> (572)..(572)
<223> S or P

<220>
<221> MOD_RES
<222> (583)..(583)
<223> P or T

<220>
<221> MOD_RES
<222> (584)..(584)
<223> E or D

<220>
<221> MOD_RES
<222> (585)..(585)
<223> S, A, or R

<220>
<221> MOD_RES
<222> (586)..(586)
<223> A, E, or V

<220>
<221> MOD_RES
<222> (587)..(587)
<223> G, E, or D

<220>
<221> MOD_RES
<222> (589)..(589)
<223> E or S

<220>
<221> MOD_RES
<222> (590)..(590)
<223> D or N

<220>
<221> MOD_RES
<222> (593)..(593)
<223> V or A

<220>
<221> MOD_RES
<222> (598)..(598)
<223> M or I

<220>
<221> MOD_RES
<222> (601)..(601)
<223> H or Y

<220>
<221> MOD_RES
<222> (602)..(602)
<223> A or G

<220>
<221> MOD_RES
<222> (613)..(613)
<223> A or S

<220>
<221> MOD_RES
<222> (615)..(615)
<223> E or A

<220>
<221> MOD_RES
<222> (616)..(616)
<223> E, A, Q, G, V, or R

<220>
<221> MOD_RES
<222> (618)..(618)
<223> A, P, or T

<220>
<221> MOD_RES
<222> (619)..(619)
<223> I, T, or P

<220>
<221> MOD_RES
<222> (620)..(620)
<223> D or A

<220>
<221> MISC_FEATURE
<222> (624)..(629)
<223> This region may encompass "V" or "VVKEAI"

<220>
<221> MOD_RES
<222> (631)..(631)
<223> K or E

<220>
<221> MOD_RES
<222> (637)..(637)
<223> T, A, or P

<220>
<221> MOD_RES
<222> (644)..(644)
<223> R, Q, or H

<220>
<221> MOD_RES
<222> (645)..(645)
<223> K or not present

<400> 147
Xaa Glu Xaa Xaa Leu Xaa Ile Phe Asp Glu Cys Arg Ser Pro Cys Xaa 
1               5                   10                  15      


Leu Thr Pro Glu Xaa Gly Lys Xaa Ile Gln Ser Lys Leu Xaa Ile Pro 
            20                  25                  30          


Xaa Asp Val Val Leu Asp Glu Gly Val Leu Tyr Tyr Ser Met Thr Ile 
        35                  40                  45              


Asn Asp Glu Gln Asn Asp Ile Xaa Asp Glu Xaa Lys Gly Glu Ser Ile 
    50                  55                  60                  


Ile Thr Xaa Gly Glu Phe Ala Thr Xaa Arg Ala Thr Arg His Tyr Val 
65                  70                  75                  80  


Xaa Gln Asp Ala Pro Phe Gly Val Ile Xaa Leu Asp Ile Thr Thr Glu 
                85                  90                  95      


Asn Gly Thr Lys Xaa Tyr Ser Xaa Asn Arg Lys Xaa Xaa Glu Phe Xaa 
            100                 105                 110         


Ile Xaa Trp Leu Val Xaa Xaa Gly Glu Asp Ser Pro Ala Ser Ile Lys 
        115                 120                 125             


Ile Ser Xaa Asp Glu Xaa Asp Gln Xaa Arg Asn Ile Ile Glu Val Pro 
    130                 135                 140                 


Lys Leu Tyr Ser Ile Asp Leu Asp Asn Gln Thr Leu Glu Gln Trp Xaa 
145                 150                 155                 160 


Xaa Gln Gly Asn Val Xaa Phe Xaa Val Thr Arg Pro Glu Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Ala Ile Ser Trp Pro Ser 
            180                 185                 190         


Val Ser Tyr Xaa Ala Ala Xaa Lys Xaa Gly Xaa Arg His Lys Arg Trp 
        195                 200                 205             


Ala Xaa Trp Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Thr Xaa Gly Xaa Xaa 
225                 230                 235                 240 


Trp Xaa Gly Gly Xaa Tyr Xaa Thr Val Ala Gly Xaa Pro Xaa Xaa Ile 
                245                 250                 255     


Xaa Val Lys Gln Gly Xaa Glu Gln Lys Xaa Val Glu Gln Arg Ile His 
            260                 265                 270         


Phe Ser Xaa Xaa Asn Ala Xaa Xaa Xaa Leu Ala Ala His Arg Val Cys 
        275                 280                 285             


Gly Val Pro Leu Glu Thr Leu Ala Arg Xaa Arg Lys Pro Arg Xaa Leu 
    290                 295                 300                 


Xaa Asp Asp Leu Xaa Cys Xaa Tyr Xaa Ala Gln Xaa Ile Val Ser Leu 
305                 310                 315                 320 


Phe Xaa Ala Thr Arg Xaa Leu Phe Xaa His Xaa Asp Ser Xaa Phe Thr 
                325                 330                 335     


Leu Asn Leu Xaa Xaa Gln Xaa Pro Xaa Val Xaa Glu Arg Leu Xaa Xaa 
            340                 345                 350         


Xaa Arg Xaa Ile Asn Glu Xaa Asn Pro Gly Xaa Val Xaa Gln Val Leu 
        355                 360                 365             


Thr Xaa Ala Arg Gln Ile Tyr Asn Asp Tyr Val Thr Xaa His Pro Xaa 
    370                 375                 380                 


Leu Xaa Pro Glu Gln Thr Ser Ala Xaa Ala Gln Ala Ala Asp Ile Leu 
385                 390                 395                 400 


Ser Leu Xaa Xaa Pro Asp Xaa Asp Xaa Xaa Cys Val Ala Xaa Xaa Xaa 
                405                 410                 415     


Asp Gln Ala Asn Ile Asn Xaa Glu Ser Arg Ser Gly Arg Ser Tyr Leu 
            420                 425                 430         


Xaa Glu Asn Arg Ala Val Ile Thr Xaa Gln Gly Val Thr Asn Trp Thr 
        435                 440                 445             


Tyr Gln Glu Leu Xaa Xaa Xaa His Gln Xaa Leu Thr Xaa Glu Xaa Tyr 
    450                 455                 460                 


Val Phe Val Gly Tyr His Gly Thr Asn His Xaa Ala Ala Gln Xaa Ile 
465                 470                 475                 480 


Val Asn Arg Ile Xaa Pro Val Pro Arg Gly Xaa Xaa Thr Glu Xaa Glu 
                485                 490                 495     


Xaa Xaa Trp Gly Gly Xaa Tyr Val Xaa Thr Xaa Ala Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Tyr Xaa Arg Xaa Xaa Xaa Gly Thr Xaa Xaa Xaa Xaa Xaa Xaa Thr 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Arg Gly Val Met Leu Xaa Val Tyr Xaa Xaa 
    530                 535                 540                 


Xaa Ala Ser Leu Glu Arg Phe Tyr Arg Xaa Asn Xaa Xaa Leu Glu Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Ile Gly His Xaa Leu Pro Leu Arg 
                565                 570                 575     


Asn Glu Ala Phe Thr Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Glu Thr 
            580                 585                 590         


Xaa Ile Gly Trp Asp Xaa Ala Ile Xaa Xaa Val Ala Ile Pro Ser Thr 
        595                 600                 605             


Ile Pro Gly Asn Xaa Tyr Xaa Xaa Leu Xaa Xaa Xaa Glu Glu Ala Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Ala Xaa Glu Gln Ser Ile Ser Xaa Lys Pro Pro 
625                 630                 635                 640 


Tyr Lys Glu Xaa Xaa Asp Glu Leu Lys 
                645                 


<210> 148
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 148
Ser Ile Ala Lys Gln Ser 
1               5       


<210> 149
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 149
Ser Ile Ala Lys Gln Ser Ile Ala Lys Gln Ser 
1               5                   10      


<210> 150
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 150
Val Val Lys Glu Ala Ile 
1               5       


<210> 151
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(30) 
<223> This sequence may encompass 1-15 "Gly Ser"
      repeating units

<400> 151
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  25                  30  


<210> 152
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(45) 
<223> This sequence may encompass 1-15 "Gly Gly Ser"
      repeating units

<400> 152
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45  


<210> 153
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 153
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 154
<211> 224
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 154
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


<210> 155
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 155
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 156
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 156
Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr 
225     



