                         SEQUENCE LISTING

<110>  GammaDelta Therapeutics Limited
 
<120>  EX VIVO GAMMA DELTA T CELL POPULATIONS

<130>  GDT-P2620PCT

<150>  GB1911799.3
<151>  2019-08-16

<150>  GB2010760.3
<151>  2020-07-13

<150>  GB2012172.9
<151>  2020-08-05

<160>  135   

<170>  PatentIn version 3.5

<210>  1
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg 
1               5                   10                  15      


Lys Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr 
            20                  25                  30          


Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Val Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Ser 
                85                  90                  95      


Leu Thr Arg Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr 
            100                 105                 110         


Val Glu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
        115                 120                 125             


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
                165                 170                 175     


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
            180                 185                 190         


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
        195                 200                 205             


Ser 
    


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Asp Tyr Ala Asp Ala Phe Asp Ile 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Ile Glu Leu Gly Ala Phe Asp Ile 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Trp Ser Gly Tyr Val Asp Val 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Asn Tyr Leu Asn Ala Phe Asp Ile 
1               5                   


<210>  6
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Ser Gly Val Ala Phe Asp Ile 
1               5               


<210>  7
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  7

His Gln Val Asp Thr Arg Thr Ala Asp Tyr 
1               5                   10  


<210>  8
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Trp Asn Asp Ala Phe Asp Ile 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Tyr Tyr Tyr Ser Met Asp Val 
1               5               


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

His Ser Trp Asn Asp Ala Phe Asp Val 
1               5                   


<210>  11
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Tyr Tyr Tyr Ser Met Asp Val 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

His Ser Trp Ser Asp Ala Phe Asp Ile 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

His Ser Trp Asn Asp Ala Phe Asp Ile 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Gln Ser Tyr Ser Thr Leu Leu Thr 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Trp Asp Ser Ser Ser Asp His Val Val 
1               5                   10      


<210>  16
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Gln Ser Tyr Ser Thr Pro Gln Val Thr 
1               5                   10  


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Gln Phe Lys Arg Tyr Pro Pro Thr 
1               5                   


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Ser Ser Tyr Thr Ser Thr Ser Thr Leu Val 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Gln Ser His Ser His Pro Pro Thr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Gln Ser Tyr Ser Thr Pro Asp Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Gln Ser Tyr Ser Thr Pro Val Thr 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Gln Ser Tyr Ser Thr Leu Leu Thr 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  26

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Tyr Ser Gly Gly Ser Thr 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Thr Tyr Tyr Arg Ser Lys Trp Ser Thr 
1               5                   


<210>  29
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  29

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Ser Gly Gly Gly Gly Thr Thr 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  31

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  33

Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  34

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Thr Tyr Tyr Gly Ser Lys Trp Tyr Asn 
1               5                   


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  39

Gly Phe Thr Val Ser Ser Asn Tyr 
1               5               


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Asp Ser Val Ser Ser Lys Ser Ala Ala 
1               5                   10  


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  47
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala 
1               5                   10  


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Ser Ile Gly Thr Tyr 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  51

Asn Ile Gly Ser Gln Ser 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Asp Ile Asn Asp Trp 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  53

Gln Ser Leu Ser Asn Tyr 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  54

Gln Asn Ile Arg Thr Trp 
1               5       


<210>  55
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Ile Ser Thr Trp 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  58

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  59
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Ser Ile Ser Thr Trp 
1               5       


<210>  60
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  60

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  61
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Ser Ile Ser Ser His 
1               5       


<210>  62
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Tyr Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  63
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  63

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Pro Ile Glu Leu Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  64
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Lys 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Ser Thr Asp Tyr Ala 
    50                  55                  60                  


Ala Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Leu Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Thr Trp Ser Gly Tyr Val Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  65
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  65

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Leu Asn Ala Phe Asp Ile Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  66
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Gly Thr Thr Tyr Ser Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Val Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  67
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gln Val Asp Thr Arg Thr Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  68
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  68

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Arg Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Trp Asn Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  70
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  70

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Trp Asn Asp Ala Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  71
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  71

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Gly Ser Lys Trp Tyr Asn Glu Tyr Ala 
    50                  55                  60                  


Leu Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  72
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Trp Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  73
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Trp Asn Asp Ala Phe Asp Ile Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  74
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  74

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Gly Gln Ser Ile Gly 
            20                  25                  30          


Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Leu Leu Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  75
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  75

Ala Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
1               5                   10                  15      


Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Gln 
            20                  25                  30          


Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met Leu Val 
        35                  40                  45              


Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser 
                85                  90                  95      


Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  76
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Pro Ala Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn 
            20                  25                  30          


Asp Trp Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Gln Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110 


<210>  77
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  77

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  78
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  78

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg 
            20                  25                  30          


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Lys Arg Tyr 
                85                  90                  95      


Pro Pro Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  79
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro 
1               5                   10                  15      


Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Arg Ser Asp Val Gly 
            20                  25                  30          


Gly Tyr Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr 
                85                  90                  95      


Ser Thr Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  80
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  80

Ala Ser Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
1               5                   10                  15      


Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile Ser 
            20                  25                  30          


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Leu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  81
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  81

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Leu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser His 
                85                  90                  95      


Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210>  82
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  83
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Ser Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
1               5                   10                  15      


Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile Ser 
            20                  25                  30          


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Leu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  84
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  84

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  85
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  85

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  86
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Asp Tyr Ala Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Gly Gln 
145                 150                 155                 160 


Ser Ile Gly Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Leu Leu Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  87
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Pro Ile Glu Leu Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ala Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val 
    130                 135                 140                 


Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
145                 150                 155                 160 


Ser Gln Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met 
                165                 170                 175     


Leu Val Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
            180                 185                 190         


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
        195                 200                 205             


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
    210                 215                 220                 


Ser Ser Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


<210>  88
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Lys 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Ser Thr Asp Tyr Ala 
    50                  55                  60                  


Ala Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Leu Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Thr Trp Ser Gly Tyr Val Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Pro 
    130                 135                 140                 


Ala Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Asn Asp Trp Leu Ala Trp Tyr Gln His Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Gln Val Thr Phe Gly Gln Gly Thr Arg Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  89
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  89

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Tyr Leu Asn Ala Phe Asp Ile Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln 
145                 150                 155                 160 


Ser Leu Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210>  90
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Gly Thr Thr Tyr Ser Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Gly Val Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser 
    130                 135                 140                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn 
145                 150                 155                 160 


Ile Arg Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Lys 
    210                 215                 220                 


Arg Tyr Pro Pro Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  91
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Gln Val Asp Thr Arg Thr Ala Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ala Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Arg 
145                 150                 155                 160 


Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln His His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Asn Arg Pro Ser 
            180                 185                 190         


Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Thr Ser Thr Ser Thr Leu Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  92
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Arg Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Trp Asn Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ala Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Gly Gln Ser Ile Ser Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  93
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  93

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Val Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser His Ser His Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp 
225                 230                 235                 240 


Ile Lys 
        


<210>  94
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  94

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Trp Asn Asp Ala Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  95
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  95

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Gly Ser Lys Trp Tyr Asn Glu Tyr Ala 
    50                  55                  60                  


Leu Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Tyr Ser Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ala Ser Asp Ile Val Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Gly Gln Ser Ile Ser Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly 
            180                 185                 190         


Val Pro Leu Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Ala Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  96
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  96

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Trp Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
145                 150                 155                 160 


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  97
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Trp Asn Asp Ala Phe Asp Ile Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
    210                 215                 220                 


Tyr Ser Thr Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  98
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  98

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10              


<210>  99
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  99
gccatggccc aggtgcagct ggtggagtct gggggaggct tggtcaagcc tggagggtcc       60

ctgagactct cctgtgcagc ctctggattc accttcagtg actactacat gagctggatc      120

cgccaggctc cagggaaggg gctggagtgg gtttcataca ttagtagtag tggtagtacc      180

atatactacg cagactctgt gaagggccga ttcaccatct ccagggacaa cgccaagaac      240

tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggctgtgta ttactgtgca      300

agggtggact acgctgatgc atttgatatc tggggccagg gcaccctggt caccgtctcg      360

agtggtggag gcggttcagg cggaggtggc tctggcggtg gcgctagcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cgcttgccgg      480

gcaggtcaga gcattggcac ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aaactcctga tctatgttgc atccagtttg caaagtgggg tcccgtcacg gttcagtggc      600

agtggatctg ggacagaatt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtacc ctcctcactt tcggcagagg gaccaaggtg      720

gaaatcaaac gtaccgcggc cgcatccgca catcatcatc accat                      765


<210>  100
<211>  768
<212>  DNA
<213>  Homo sapiens

<400>  100
gccatggccg aggtgcagct gttggagtct gggggaggct tggtacagcc tggcaggtcc       60

ctgagactct cctgtgcagc ctctgggttc accgtcagta gcaactacat gagctgggtc      120

cgccaggctc cagggaaggg gctggagtgg gtctcagtta tttatagcgg tggtagcaca      180

tactacgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      240

ctgtatcttc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgagc      300

cccatagagc tgggtgcttt tgatatctgg ggccaaggaa ccctggtcac cgtctcgagt      360

ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg ctagctccta tgagctgact      420

cagccaccct cagtgtcagt ggccccagga aagacggcca ggattacctg tgggggaaac      480

aacattggaa gtcaaagtgt gcactggtac cagcagaagc caggccaggc ccctatgctg      540

gtcatctatt atgatagcga ccggccctca gggatccctg agcgattctc tggctccaac      600

tctgggaaca cggccaccct gaccatcagc agggtcgaag ccggggatga ggccgactat      660

tactgtcagg tgtgggatag tagtagtgat catgtggtat tcggcggcgg gaccaagctg      720

accgtcctag gtcagcccgc ggccgcatcc gcacatcatc atcaccat                   768


<210>  101
<211>  774
<212>  DNA
<213>  Homo sapiens

<400>  101
gccatggccc aggtacagct gcagcagtca ggtccaggac tggtgaagcc ctcgcagacc       60

ctctcactca cctgtgccat ctccggggac agtgtctcca gcaaaagtgc tgcttggaac      120

tggatcaggc agtccccatc gagaggcctt gagtggctgg gaaggacata ctacaggtcc      180

aagtggtcta ctgattatgc agcatctgtg aaaagtcgaa taaccatcaa cccagacaca      240

tccaagaacc agctctccct gcagttaaac tctgtgactc ccgaggacac ggctgtgtat      300

tactgtgcaa gaacgtggag tggttatgtg gacgtctggg gccaaggaac cctggtcacc      360

gtctcgagtg gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgc tagcgacatc      420

cagatgaccc agtcccctcc cgccctgtct gcatctgtgg gagacagagt caccatcact      480

tgccgggcca gtcaagatat taatgactgg ttggcctggt atcagcataa acctgggaaa      540

gcccctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc atcaaggttc      600

agcggcagtg gatctgggac agaattcact ctcaccatca gcagcctgca gcctgatgat      660

tttgcaactt actactgtca acagagttac agtacccctc aggtcacttt tggccagggg      720

acacgactgg agatcaaacg taccgcggcc gcatccgcac atcatcatca ccat            774


<210>  102
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  102
gccatggccg aggtgcagct gttggagtct gggggaggct tggtcaagcc tggagggtcc       60

ctgagactct cctgtgcggc ctctggattc accttcagtg actactacat gagctggatc      120

cgccaggctc cagggaaggg gctggagtgg gtttcataca ttagtagtag tggtagtacc      180

atatactacg cagactctgt gaagggccga ttcaccatct ccagggacaa cgccaagaac      240

tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtgta ttactgtgcg      300

agagaaaact atctaaatgc ttttgatatc tggggccgtg gcaccctggt caccgtctcg      360

agtggtggag gcggttcagg cggaggtggc tctggcggtg gcgctagcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

acaagtcaga gccttagtaa ttacttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgcg      660

acttactact gtcaacagag ttacagtacc cctctcactt tcggcggagg gaccaagcta      720

gagatcaaac gtaccgcggc cgcatccgca catcatcatc accat                      765


<210>  103
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  103
gccatggccg aggtgcagct gttggagtct gggggaggct tggtacagcc tggggggtcc       60

ctgagactct cctgtgcagc ctctggattc acctttagca gctatgccat gagctgggtc      120

cgccaggctc cagggaaggg gctggagtgg gtctcagcta ttagtggtgg tggtggtacc      180

acatactcct cagactccgt gaagggccgg ttcaccatct ccagagacaa ttccaagaac      240

acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca cggctgtgta ttactgtgcg      300

agagattcag gggttgcttt tgatatctgg ggccaaggaa ccctggtcac cgtctcgagt      360

ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg ctagcgacat ccagatgacc      420

cagtctccat ccttcctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggcc      480

agtcagaata tacgtacctg gttggcctgg tatcagcaga aaccagggag agcccctaag      540

ctcctgatct atgatgcctc cagtttggaa agtggggtcc catcaaggtt cagcggcagt      600

ggatctggga ctgatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact      660

tattactgtc aacagtttaa acgttaccct ccgacgtttg gcctggggac caaggtggag      720

atcaaacgta ccgcggccgc atccgcacat catcatcacc at                         762


<210>  104
<211>  780
<212>  DNA
<213>  Homo sapiens

<400>  104
gccatggccc aggtccagct ggtacagtct ggagcagagg tgaaaaagcc cggggagtct       60

ctgaagatct cctgtaaggg ttctggatac agctttacca gctactggat cggctgggtg      120

cgccagatgc ccgggaaagg cctggagtgg atggggatca tctatcctgg tgactctgat      180

accagataca gcccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccatcagc      240

accgcctacc tgcagtggag cagcctgaag gcctcggaca ccgccatgta ttattgtgcg      300

agacatcagg ttgatacacg gacggctgat tactggggcc agggaaccct ggtcaccgtc      360

tcgagtggtg gaggcggttc aggcggaggt ggctctggcg gtggcgctag ccagtctgcg      420

ctgactcagc ctgcctccgt gtctgggtct cctggacagt cggtcaccat ctcctgcact      480

ggaaccagga gtgacgttgg tggttataac tatgtctcct ggtaccaaca ccacccaggc      540

aaagccccca aactcatgat ttatgaggtc agtaatcggc cctcaggggt ttctaatcgc      600

ttctctggct ccaagtctgg caacacggcc tccctgacca tctctgggct ccaggctgag      660

gacgaggctg attattactg cagctcatat acaagcacca gcactctggt attcggcgga      720

gggaccaagc tgaccgtcct aggtcagccc gcggccgcat ccgcacatca tcatcaccat      780


<210>  105
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  105
gccatggccc aggtacagct gcagcagtca ggtccaggac tggtgaagcc ctcgcagacc       60

ctctcactca cctgtgccat ctccggggac agtgtctcta gcaacagtgc tgcttggaac      120

tggatcaggc agtccccatc gagaggcctt gagtggctgg gaaggacata ctacaggtcc      180

aagtggtata atgattatgc agtatctgtg agaagtcgaa taaccatcaa cccagacaca      240

tccaagaacc agttctccct gcagctgaac tctgtgactc ccgaggacac ggctgtgtat      300

tactgtgcaa gaagctggaa tgatgctttt gatatctggg ggcaagggac cacggtcacc      360

gtctcgagtg gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgc tagcgatatt      420

gtgatgacac agtctccttc caccctgtct gcatctatag gagacagagt caccatcact      480

tgccgggccg gtcagagtat tagtacctgg ttggcctggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc attaaggttc      600

agcggcagtg gatctgggac agatttcact ctcaccatca gcagtctgca acctgaagat      660

tttgcaactt actactgtca acagagttac agtaccccgc tcactttcgg cggagggacc      720

aaggtggaga tcaaacgtac cgcggccgca tccgcacatc atcatcacca t               771


<210>  106
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  106
gccatggccc aggtacagct gcagcagtca ggtccaggcc tggtgaagcc ctcgcagacc       60

ctctcactca cctgtgtcat ctccggggac agtgtctcta gcaacagtgc tgcttggaac      120

tggatcaggc agtccccatc gcgaggcctt gagtggctgg gaaggacata ctacaggtcc      180

aagtggtata atgattatgc agtatctgtg aaaagtcgaa taaccatcaa cccagacaca      240

tccaagaacc agttctccct gcagctgaac tctgtgactc ccgaggacac ggctgtctat      300

tattgtgcaa gagactacta ctacagtatg gacgtctggg gccaagggac aatggtcacc      360

gtctcgagtg gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgc tagcgacatc      420

cagatgaccc agtctccctc caccctgtct gcatctgtag gagacagagt caccatcact      480

tgccgggcca gtcagagtat tagtagctgg ttggcctggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc attaaggttc      600

agcggcagtg gatctgggac agaattcact ctcaccatca gcagcctgca gcctgatgat      660

tttgcaactt attactgtca acagagtcac agtcaccccc ctactttcgg ccctgggacc      720

aaagtggata tcaaacgtac cgcggccgca tccgcacatc atcatcacca t               771


<210>  107
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  107
gccatggccc aggtgcagct ggtggagtct gggggaggct tggtcaagcc tggagggtcc       60

ctgagactct cctgtgcagc ctctggattc accttcagtg actactacat gagctggatc      120

cgccaggctc cagggaaggg gctggagtgg gtttcataca ttagtagtag tggtagtacc      180

atatactacg cagactctgt gaagggccga ttcaccatct ccagggacaa cgccaagaac      240

tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtgta ttactgtgcg      300

agacatagct ggaatgatgc ttttgatgtc tggggccagg gaaccctggt caccgtctcg      360

agtggtggag gcggttcagg cggaggtggc tctggcggtg gcgctagcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtctccat cacctgccgg      480

gcaagtcaga gcattagcag ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcagcagag ttacagtacc cccgacactt tcggcggagg gaccaaggtg      720

gaaatcaaac gtaccgcggc cgcatccgca catcatcatc accat                      765


<210>  108
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  108
gccatggccc aggtacagct gcagcagtca ggtccaggac tggtgaagcc ctcgcagacc       60

ctctcactca cctgtgccat ctccggggac agtgtctcta gcaacagtgc tgcttggaac      120

tggatcaggc agtccccatc gagaggcctt gagtggctgg gaaggacata ctacgggtcc      180

aagtggtata atgagtatgc actatctgtg aaaagtcgaa taatcatcaa cccagacaca      240

tccaagaacc agttctccct gcagctgaac tctgtgactc ccgaggacac ggctgtctat      300

tattgtgcaa gagactacta ctacagtatg gacgtctggg gccagggaac cctggtcacc      360

gtctcgagtg gtggaggcgg ttcaggcgga ggtggctctg gcggtggcgc tagcgatatt      420

gtgatgactc agtctccttc caccctgtct gcatctatag gagacagagt caccatcact      480

tgccgggccg gtcagagtat tagtacctgg ttggcctggt atcagcagaa accagggaaa      540

gcccctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc attaaggttc      600

agcggcagtg gatctgggac agaattcact ctcgccatca gcagcctgca gcctgatgat      660

tttgcaactt actactgtca acagagttac agtaccccgg taacttttgg ccaggggacc      720

aaggtggaga tcaaacgtac cgcggccgca tccgcacatc atcatcacca t               771


<210>  109
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  109
gccatggccg aggtgcagct gttggagtct gggggaggct tggtcaagcc tggagggtcc       60

ctgagactct cctgtgcagc ctctggattc accttcagtg actactacat gagctggatc      120

cgccaggctc cagggaaggg gctggagtgg gtttcataca ttagtagtag tggtagtacc      180

atatactacg cagactctgt gaagggccga ttcaccatct ccagggacaa cgccaagaac      240

tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtgta ttactgtgcg      300

agacatagct ggagtgatgc ttttgatatc tggggccaag gaaccctggt caccgtctcg      360

agtggtggag gcggttcagg cggaggtggc tctggcggtg gcgctagcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccag      480

gcgagtcagg acattagcaa ctatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctacgatgc atccaatttg gaaacagggg tcccatcaag gttcagtgga      600

agtggatctg ggacagattt cactctcacc atcagcagtc tgcaacctga agattttgca      660

acttactact gtcaacagag ttacagtact cctctcactt tcggcggagg gaccaaggtg      720

gagatcaaac gtaccgcggc cgcatccgca catcatcatc accat                      765


<210>  110
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  110
gccatggccg aagtgcagct ggtggagtcc gggggaggct tagttcagcc tggggggtcc       60

ctgagactct cctgtgcagc ctctggattc accttcagtg actactacat gagctggatc      120

cgccaggctc cagggaaggg gctggagtgg gtttcataca ttagtagtag tggtagtacc      180

atatactacg cagactctgt gaagggccga ttcaccatct ccagggacaa cgccaagaac      240

tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtgta ttactgtgcg      300

agacatagct ggaatgatgc ttttgatatc tggggccgtg gcaccctggt caccgtctcg      360

agtggtggag gcggttcagg cggaggtggc tctggcggtg gcgctagcga catccagatg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcaga gcattagcag ccatttaaat tggtatcagc agaaaccagg gaaagcccct      540

aagctcctga tctatgctgc atccagtttg caaagtgggg tcccatccag gttcagtgcc      600

agtggatctg ggacagattt cactctcacc atcagcagcc tgcagcctga agattttgca      660

acttactact gtcaacagag ttacagtacc ctgctcactt tcggcggagg gaccaaggtg      720

gaaatcaaac gtaccgcggc cgcatccgca catcatcatc accat                      765


<210>  111
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  111

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Gly Gln Ser Ile Gly 
            20                  25                  30          


Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Leu Leu Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Val Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser 
            260                 265                 270         


Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        275                 280                 285             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    290                 295                 300                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Asp Tyr Ala Asp Ala 
305                 310                 315                 320 


Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  112
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  112

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Pro Ala Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn 
            20                  25                  30          


Asp Trp Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Gln Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr 
            100                 105                 110         


Ala Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Gln Gln Ser 
    210                 215                 220                 


Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala 
225                 230                 235                 240 


Ile Ser Gly Asp Ser Val Ser Ser Lys Ser Ala Ala Trp Asn Trp Ile 
                245                 250                 255     


Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr 
            260                 265                 270         


Arg Ser Lys Trp Ser Thr Asp Tyr Ala Ala Ser Val Lys Ser Arg Ile 
        275                 280                 285             


Thr Ile Asn Pro Asp Thr Ser Lys Asn Gln Leu Ser Leu Gln Leu Asn 
    290                 295                 300                 


Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Trp 
305                 310                 315                 320 


Ser Gly Tyr Val Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                325                 330                 335     


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
            340                 345                 350         


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
        355                 360                 365             


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
    370                 375                 380                 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
                405                 410                 415     


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
            420                 425                 430         


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        435                 440                 445             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    450                 455                 460                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
465                 470                 475                 480 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                485                 490                 495     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            500                 505                 510         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        515                 520                 525             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    530                 535                 540                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
545                 550                 555                 560 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                565                 570                 575     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            580                 585                 590         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        595                 600                 605             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    610                 615                 620                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
625                 630                 635                 640 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                645                 650                 655     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665         


<210>  113
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  113

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Glu Val Gln Leu Leu Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser 
            260                 265                 270         


Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        275                 280                 285             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    290                 295                 300                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Asn Tyr Leu Asn Ala 
305                 310                 315                 320 


Phe Asp Ile Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  114
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  114

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Arg 
            20                  25                  30          


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Lys Arg Tyr 
                85                  90                  95      


Pro Pro Thr Phe Gly Leu Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Glu Val Gln Leu Leu Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Gly Gly Gly 
            260                 265                 270         


Thr Thr Tyr Ser Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        275                 280                 285             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    290                 295                 300                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Val Ala Phe 
305                 310                 315                 320 


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                325                 330                 335     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            340                 345                 350         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        355                 360                 365             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    370                 375                 380                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
385                 390                 395                 400 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                405                 410                 415     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            420                 425                 430         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        435                 440                 445             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    450                 455                 460                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
465                 470                 475                 480 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                485                 490                 495     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            500                 505                 510         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        515                 520                 525             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    530                 535                 540                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
545                 550                 555                 560 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                565                 570                 575     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            580                 585                 590         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        595                 600                 605             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    610                 615                 620                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
625                 630                 635                 640 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                645                 650                 655     


Leu Ser Leu Ser Pro Gly Lys 
            660             


<210>  115
<211>  667
<212>  PRT
<213>  Homo sapiens

<400>  115

Ala Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro 
1               5                   10                  15      


Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Arg Ser Asp Val Gly 
            20                  25                  30          


Gly Tyr Asn Tyr Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr 
                85                  90                  95      


Ser Thr Ser Thr Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Ala Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Gln Val Gln Leu Val Gln 
    210                 215                 220                 


Ser Gly Ala Glu Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys 
225                 230                 235                 240 


Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg 
                245                 250                 255     


Gln Met Pro Gly Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly 
            260                 265                 270         


Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile 
        275                 280                 285             


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
    290                 295                 300                 


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala Arg His Gln Val Asp 
305                 310                 315                 320 


Thr Arg Thr Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                325                 330                 335     


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
            340                 345                 350         


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
        355                 360                 365             


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
    370                 375                 380                 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
385                 390                 395                 400 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
                405                 410                 415     


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
            420                 425                 430         


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
        435                 440                 445             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    450                 455                 460                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
465                 470                 475                 480 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                485                 490                 495     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            500                 505                 510         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        515                 520                 525             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    530                 535                 540                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
545                 550                 555                 560 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                565                 570                 575     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            580                 585                 590         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        595                 600                 605             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    610                 615                 620                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
625                 630                 635                 640 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                645                 650                 655     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665         


<210>  116
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  116

Ala Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
1               5                   10                  15      


Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Gln 
            20                  25                  30          


Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Met Leu Val 
        35                  40                  45              


Ile Tyr Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu 
65                  70                  75                  80  


Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser 
                85                  90                  95      


Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Ala Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser Glu Val Gln Leu Leu Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser 
            260                 265                 270         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        275                 280                 285             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    290                 295                 300                 


Asp Thr Ala Val Tyr Tyr Cys Ala Ser Pro Ile Glu Leu Gly Ala Phe 
305                 310                 315                 320 


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                325                 330                 335     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            340                 345                 350         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        355                 360                 365             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    370                 375                 380                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
385                 390                 395                 400 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                405                 410                 415     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
            420                 425                 430         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        435                 440                 445             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    450                 455                 460                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
465                 470                 475                 480 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                485                 490                 495     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            500                 505                 510         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        515                 520                 525             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    530                 535                 540                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
545                 550                 555                 560 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                565                 570                 575     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            580                 585                 590         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        595                 600                 605             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    610                 615                 620                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
625                 630                 635                 640 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                645                 650                 655     


Leu Ser Leu Ser Pro Gly Lys 
            660             


<210>  117
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  117

Ala Ser Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
1               5                   10                  15      


Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile Ser 
            20                  25                  30          


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Leu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Gln Gln Ser Gly 
    210                 215                 220                 


Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile 
225                 230                 235                 240 


Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg 
                245                 250                 255     


Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg 
            260                 265                 270         


Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Arg Ser Arg Ile Thr 
        275                 280                 285             


Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser 
    290                 295                 300                 


Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Trp Asn 
305                 310                 315                 320 


Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                325                 330                 335     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
            340                 345                 350         


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        355                 360                 365             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    370                 375                 380                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
385                 390                 395                 400 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
                405                 410                 415     


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            420                 425                 430         


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
        435                 440                 445             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    450                 455                 460                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
465                 470                 475                 480 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                485                 490                 495     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            500                 505                 510         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        515                 520                 525             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    530                 535                 540                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
545                 550                 555                 560 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                565                 570                 575     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            580                 585                 590         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        595                 600                 605             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    610                 615                 620                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
625                 630                 635                 640 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                645                 650                 655     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665     


<210>  118
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  118

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Leu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser His 
                85                  90                  95      


Pro Pro Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Gln Gln Ser Gly 
    210                 215                 220                 


Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Val Ile 
225                 230                 235                 240 


Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg 
                245                 250                 255     


Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg 
            260                 265                 270         


Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr 
        275                 280                 285             


Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser 
    290                 295                 300                 


Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr 
305                 310                 315                 320 


Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                325                 330                 335     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
            340                 345                 350         


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        355                 360                 365             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    370                 375                 380                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
385                 390                 395                 400 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
                405                 410                 415     


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            420                 425                 430         


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
        435                 440                 445             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    450                 455                 460                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
465                 470                 475                 480 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                485                 490                 495     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            500                 505                 510         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        515                 520                 525             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    530                 535                 540                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
545                 550                 555                 560 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                565                 570                 575     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            580                 585                 590         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        595                 600                 605             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    610                 615                 620                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
625                 630                 635                 640 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                645                 650                 655     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665     


<210>  119
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  119

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Asp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Val Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser 
            260                 265                 270         


Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        275                 280                 285             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    290                 295                 300                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Ser Trp Asn Asp Ala 
305                 310                 315                 320 


Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  120
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  120

Ala Ser Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser 
1               5                   10                  15      


Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Ser Ile Ser 
            20                  25                  30          


Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Leu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ala Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Gln Val Gln Leu Gln Gln Ser Gly 
    210                 215                 220                 


Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile 
225                 230                 235                 240 


Ser Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg 
                245                 250                 255     


Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Gly 
            260                 265                 270         


Ser Lys Trp Tyr Asn Glu Tyr Ala Leu Ser Val Lys Ser Arg Ile Ile 
        275                 280                 285             


Ile Asn Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser 
    290                 295                 300                 


Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr 
305                 310                 315                 320 


Tyr Ser Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                325                 330                 335     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
            340                 345                 350         


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        355                 360                 365             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    370                 375                 380                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
385                 390                 395                 400 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
                405                 410                 415     


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            420                 425                 430         


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
        435                 440                 445             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    450                 455                 460                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
465                 470                 475                 480 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                485                 490                 495     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            500                 505                 510         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        515                 520                 525             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    530                 535                 540                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
545                 550                 555                 560 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                565                 570                 575     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            580                 585                 590         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        595                 600                 605             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    610                 615                 620                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
625                 630                 635                 640 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                645                 650                 655     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 665     


<210>  121
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  121

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser 
            20                  25                  30          


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Glu Val Gln Leu Leu Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser 
            260                 265                 270         


Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        275                 280                 285             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    290                 295                 300                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Ser Trp Ser Asp Ala 
305                 310                 315                 320 


Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  122
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  122

Ala Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser 
            20                  25                  30          


Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr 
                85                  90                  95      


Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys Glu Val Gln Leu Val Glu Ser Gly 
    210                 215                 220                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
225                 230                 235                 240 


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala 
                245                 250                 255     


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser 
            260                 265                 270         


Thr Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        275                 280                 285             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    290                 295                 300                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Ser Trp Asn Asp Ala 
305                 310                 315                 320 


Phe Asp Ile Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                325                 330                 335     


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
            340                 345                 350         


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
        355                 360                 365             


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
    370                 375                 380                 


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
385                 390                 395                 400 


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
                405                 410                 415     


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
            420                 425                 430         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        435                 440                 445             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    450                 455                 460                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
465                 470                 475                 480 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                485                 490                 495     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            500                 505                 510         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        515                 520                 525             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    530                 535                 540                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
545                 550                 555                 560 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                565                 570                 575     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            580                 585                 590         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        595                 600                 605             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    610                 615                 620                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
625                 630                 635                 640 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                645                 650                 655     


Ser Leu Ser Leu Ser Pro Gly Lys 
            660                 


<210>  123
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRDV1(3OMZ) TRAC antigen sequence

<400>  123

Ala Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg 
1               5                   10                  15      


Lys Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr 
            20                  25                  30          


Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Val Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Ser 
                85                  90                  95      


Leu Thr Arg Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr 
            100                 105                 110         


Val Glu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
        115                 120                 125             


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
                165                 170                 175     


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
            180                 185                 190         


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
        195                 200                 205             


Ser Cys Thr Thr Ala Pro Ser Ala Gln Leu Lys Lys Lys Leu Gln Ala 
    210                 215                 220                 


Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys 
225                 230                 235                 240 


Lys Lys Leu Ala Gln Gly Ser Gly His His His His His His 
                245                 250                 


<210>  124
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional scFv tag sequence (kappa sequence + His tag)

<400>  124

Arg Thr Ala Ala Ala Ser Ala His His His His His 
1               5                   10          


<210>  125
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional scFv tag sequence (kappa sequence + His and FLAG tag)

<400>  125

Arg Thr Ala Ala Ala Ser Ala His His His His His His Lys Leu Asp 
1               5                   10                  15      


Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys 
            20                  25                  30          


Asp Asp Asp Asp Lys 
        35          


<210>  126
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional scFv tag sequence (lambda sequence + His tag)

<400>  126

Gly Gln Pro Ala Ala Ala Ser Ala His His His His His 
1               5                   10              


<210>  127
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Optional scFv tag sequence (lambda sequence + His and FLAG tag)

<400>  127

Gly Gln Pro Ala Ala Ala Ser Ala His His His His His His Lys Leu 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
            20                  25                  30          


Lys Asp Asp Asp Asp Lys 
        35              


<210>  128
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  128

Ala Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg 
1               5                   10                  15      


Lys Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr 
            20                  25                  30          


Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Val Asn Phe Lys Lys Ala Val Lys Ser Val Ala Leu Thr Ile Ser Ala 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu Ser 
                85                  90                  95      


Leu Thr Arg Ala Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr 
            100                 105                 110         


Val Glu Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
        115                 120                 125             


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
                165                 170                 175     


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
            180                 185                 190         


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
        195                 200                 205             


Ser Cys Thr Thr Ala Pro Ser Ala Gln Leu Lys Lys Lys Leu Gln Ala 
    210                 215                 220                 


Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp Lys Leu Gln Ala Leu Lys 
225                 230                 235                 240 


Lys Lys Leu Ala Gln Gly Ser Gly His His His His His His 
                245                 250                 


<210>  129
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Leu Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr Ser 
1               5                   10                  15      


Gly Ser Ser Val 
            20  


<210>  130
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  130

Ala Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg 
1               5                   10                  15      


Lys Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr 
            20                  25                  30          


Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Val Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala 
65                  70                  75                  80  


Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Glu 
                85                  90                  95  


<210>  131
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  131

Thr Asp Lys Leu Ile Phe Gly Lys Gly Thr Arg Val Thr Val Glu Pro 
1               5                   10                  15      


<210>  132
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  132

Leu Thr Ala Gln Leu Phe Phe Gly Lys Gly Thr Gln Leu Ile Val Glu 
1               5                   10                  15      


Pro 
    


<210>  133
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  133

Ser Trp Asp Thr Arg Gln Met Phe Phe Gly Thr Gly Ile Lys Leu Phe 
1               5                   10                  15      


Val Glu Pro 
            


<210>  134
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  134

Arg Pro Leu Ile Phe Gly Lys Gly Thr Tyr Leu Glu Val Gln Gln 
1               5                   10                  15  


<210>  135
<211>  153
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Xaa Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly 
1               5                   10                  15      


Thr Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg 
            20                  25                  30          


Ile Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile 
        35                  40                  45              


Val Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr 
    50                  55                  60                  


Glu Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val 
65                  70                  75                  80  


His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys 
                85                  90                  95      


Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys 
            100                 105                 110         


Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
        115                 120                 125             


Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe 
    130                 135                 140                 


Leu Leu Thr Ala Lys Leu Phe Phe Leu 
145                 150             


