                         SEQUENCE LISTING

<110>  University College Cardiff Consultants Ltd
 
<120>  ANTI-C7 ANTIBODY OR ANTIBODY FRAGMENT

<130>  P138255PC00

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full VH Sequence of 17E7

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Tyr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Ser Gly Gly Tyr Asp Val Gly Gly Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 of 17E7

<400>  2

Thr Tyr Trp Met His 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 of 17E7

<400>  3

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Tyr Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 of 17E7

<400>  4

Ser Gly Gly Tyr Asp Val Gly Gly Leu Asp Tyr 
1               5                   10      


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full VL Sequence of 17E7

<400>  5

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Gly Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Met Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 of 17E7

<400>  6

Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 of 17E7

<400>  7

Phe Ala Ser Gln Ser Ile Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 of 17E7

<400>  8

Gln Asn Gly His Ser Phe Pro Phe Thr 
1               5                   


<210>  9
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe 
1               5                   10                  15      


Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 
            20                  25                  30          


Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 
        35                  40                  45              


Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gln Pro Cys Val Gly 
    50                  55                  60                  


Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro Thr 
65                  70                  75                  80  


Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys Ile 
                85                  90                  95      


Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp Ser 
            100                 105                 110         


Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys Asp 
        115                 120                 125             


Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr Asn 
    130                 135                 140                 


Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser Phe 
145                 150                 155                 160 


Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe Tyr 
                165                 170                 175     


Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile Asn 
            180                 185                 190         


Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val Lys 
        195                 200                 205             


His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe Phe 
    210                 215                 220                 


Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn Glu 
225                 230                 235                 240 


Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr Val 
                245                 250                 255     


Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu Ala 
            260                 265                 270         


Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp Tyr 
        275                 280                 285             


Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu Gln 
    290                 295                 300                 


Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp Ser 
305                 310                 315                 320 


Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys Cys 
                325                 330                 335     


Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly Cys 
            340                 345                 350         


Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn Asn 
        355                 360                 365             


Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe Ile 
    370                 375                 380                 


Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys Arg 
385                 390                 395                 400 


Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val Ile 
                405                 410                 415     


Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro Cys 
            420                 425                 430         


Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr Leu 
        435                 440                 445             


Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly Leu 
    450                 455                 460                 


Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr Thr 
465                 470                 475                 480 


Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala Gly 
                485                 490                 495     


Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys Val 
            500                 505                 510         


Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro Ser 
        515                 520                 525             


Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln Cys 
    530                 535                 540                 


Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys Phe 
545                 550                 555                 560 


Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala Leu 
                565                 570                 575     


Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly Lys 
            580                 585                 590         


Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn Pro 
        595                 600                 605             


Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met His 
    610                 615                 620                 


Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile Gln 
625                 630                 635                 640 


Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr Val 
                645                 650                 655     


Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu Cys 
            660                 665                 670         


Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys Val 
        675                 680                 685             


Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg Trp 
    690                 695                 700                 


Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu Cys 
705                 710                 715                 720 


Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg Ile 
                725                 730                 735     


Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly Arg 
            740                 745                 750         


Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser Ala 
        755                 760                 765             


Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala Glu 
    770                 775                 780                 


Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu Gly 
785                 790                 795                 800 


Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser Glu 
                805                 810                 815     


Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val Thr 
            820                 825                 830         


Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 
        835                 840         


<210>  10
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg Trp Glu Lys Leu Gln 
1               5                   10                  15      


Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu Cys Gly Pro Ser Leu 
            20                  25                  30          


Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg Ile Leu Pro Leu Thr 
        35                  40                  45              


Val Cys Lys Met His Val Leu His Cys Gln Gly Arg Asn Tyr Thr Leu 
    50                  55                  60                  


Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser Ala Glu Lys Ala Cys 
65                  70                  75                  80  


Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala Glu Ser Ser Lys Cys 
                85                  90                  95      


Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu Gly Phe Ser Ile Cys 
            100                 105                 110         


Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser Glu Cys Glu Ala Gly 
        115                 120                 125             


Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val Thr Ser Ile Arg Pro 
    130                 135                 140                 


Cys Ala Ala Glu Thr Gln 
145                 150 


<210>  11
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full VH Sequence of 2H2

<400>  11

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Lys Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu His Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 of 2H2

<400>  12

Ser Tyr Trp Met His 
1               5   


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 of 2H2

<400>  13

Arg Ile Asp Pro Asn Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 of 2H2

<400>  14

Glu His Asp Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  15
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full VL Sequence of 2H2

<400>  15

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 of 2H2

<400>  16

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 of 2H2

<400>  17

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 of 2H2

<400>  18

Met Gln His Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  19
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full VH Sequence of 73D1

<400>  19

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asn Asn Gly Gly Pro Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Cys Gly Asn Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H1 of 73D1

<400>  20

Asp Tyr Asn Met His 
1               5   


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H2 of 73D1

<400>  21

Tyr Ile Asn Pro Asn Asn Gly Gly Pro Ser Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-H3 of 73D1

<400>  22

Gly Asn Tyr Pro Asp Tyr 
1               5       


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full VL Sequence of 73D1

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L1 of 73D1

<400>  24

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L2 of 73D1

<400>  25

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 of 73D1

<400>  26

Gln His Phe Trp Ser Thr Pro Leu Thr 
1               5                   


