﻿               SEQUENCE LISTING

<110> Universität Basel

<120> CELL THERAPY METHODS

<130> AC2078 PCT BS

<150> EP 19 19 2299.6
<151> 2019-08-19

<160> 7

<170> BiSSAP 1.3.6

<210> 1
<211> 889
<212> PRT
<213> Homo sapiens


<220> 
<223> IRP1

<400> 1
Met Ser Asn Pro Phe Ala His Leu Ala Glu Pro Leu Asp Pro Val Gln 
1               5                   10                  15      
Pro Gly Lys Lys Phe Phe Asn Leu Asn Lys Leu Glu Asp Ser Arg Tyr 
            20                  25                  30          
Gly Arg Leu Pro Phe Ser Ile Arg Val Leu Leu Glu Ala Ala Ile Arg 
        35                  40                  45              
Asn Cys Asp Glu Phe Leu Val Lys Lys Gln Asp Ile Glu Asn Ile Leu 
    50                  55                  60                  
His Trp Asn Val Thr Gln His Lys Asn Ile Glu Val Pro Phe Lys Pro 
65                  70                  75                  80  
Ala Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ala Val Val Asp 
                85                  90                  95      
Phe Ala Ala Met Arg Asp Ala Val Lys Lys Leu Gly Gly Asp Pro Glu 
            100                 105                 110         
Lys Ile Asn Pro Val Cys Pro Ala Asp Leu Val Ile Asp His Ser Ile 
        115                 120                 125             
Gln Val Asp Phe Asn Arg Arg Ala Asp Ser Leu Gln Lys Asn Gln Asp 
    130                 135                 140                 
Leu Glu Phe Glu Arg Asn Arg Glu Arg Phe Glu Phe Leu Lys Trp Gly 
145                 150                 155                 160 
Ser Gln Ala Phe His Asn Met Arg Ile Ile Pro Pro Gly Ser Gly Ile 
                165                 170                 175     
Ile His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val Phe Asp Gln 
            180                 185                 190         
Asp Gly Tyr Tyr Tyr Pro Asp Ser Leu Val Gly Thr Asp Ser His Thr 
        195                 200                 205             
Thr Met Ile Asp Gly Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile 
    210                 215                 220                 
Glu Ala Glu Ala Val Met Leu Gly Gln Pro Ile Ser Met Val Leu Pro 
225                 230                 235                 240 
Gln Val Ile Gly Tyr Arg Leu Met Gly Lys Pro His Pro Leu Val Thr 
                245                 250                 255     
Ser Thr Asp Ile Val Leu Thr Ile Thr Lys His Leu Arg Gln Val Gly 
            260                 265                 270         
Val Val Gly Lys Phe Val Glu Phe Phe Gly Pro Gly Val Ala Gln Leu 
        275                 280                 285             
Ser Ile Ala Asp Arg Ala Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly 
    290                 295                 300                 
Ala Thr Ala Ala Phe Phe Pro Val Asp Glu Val Ser Ile Thr Tyr Leu 
305                 310                 315                 320 
Val Gln Thr Gly Arg Asp Glu Glu Lys Leu Lys Tyr Ile Lys Lys Tyr 
                325                 330                 335     
Leu Gln Ala Val Gly Met Phe Arg Asp Phe Asn Asp Pro Ser Gln Asp 
            340                 345                 350         
Pro Asp Phe Thr Gln Val Val Glu Leu Asp Leu Lys Thr Val Val Pro 
        355                 360                 365             
Cys Cys Ser Gly Pro Lys Arg Pro Gln Asp Lys Val Ala Val Ser Asp 
    370                 375                 380                 
Met Lys Lys Asp Phe Glu Ser Cys Leu Gly Ala Lys Gln Gly Phe Lys 
385                 390                 395                 400 
Gly Phe Gln Val Ala Pro Glu His His Asn Asp His Lys Thr Phe Ile 
                405                 410                 415     
Tyr Asp Asn Thr Glu Phe Thr Leu Ala His Gly Ser Val Val Ile Ala 
            420                 425                 430         
Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Ser Val Met Leu Gly 
        435                 440                 445             
Ala Gly Leu Leu Ala Lys Lys Ala Val Asp Ala Gly Leu Asn Val Met 
    450                 455                 460                 
Pro Tyr Ile Lys Thr Ser Leu Ser Pro Gly Ser Gly Val Val Thr Tyr 
465                 470                 475                 480 
Tyr Leu Gln Glu Ser Gly Val Met Pro Tyr Leu Ser Gln Leu Gly Phe 
                485                 490                 495     
Asp Val Val Gly Tyr Gly Cys Met Thr Cys Ile Gly Asn Ser Gly Pro 
            500                 505                 510         
Leu Pro Glu Pro Val Val Glu Ala Ile Thr Gln Gly Asp Leu Val Ala 
        515                 520                 525             
Val Gly Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Val His Pro 
    530                 535                 540                 
Asn Thr Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Ile Ala Tyr 
545                 550                 555                 560 
Ala Ile Ala Gly Thr Ile Arg Ile Asp Phe Glu Lys Glu Pro Leu Gly 
                565                 570                 575     
Val Asn Ala Lys Gly Gln Gln Val Phe Leu Lys Asp Ile Trp Pro Thr 
            580                 585                 590         
Arg Asp Glu Ile Gln Ala Val Glu Arg Gln Tyr Val Ile Pro Gly Met 
        595                 600                 605             
Phe Lys Glu Val Tyr Gln Lys Ile Glu Thr Val Asn Glu Ser Trp Asn 
    610                 615                 620                 
Ala Leu Ala Thr Pro Ser Asp Lys Leu Phe Phe Trp Asn Ser Lys Ser 
625                 630                 635                 640 
Thr Tyr Ile Lys Ser Pro Pro Phe Phe Glu Asn Leu Thr Leu Asp Leu 
                645                 650                 655     
Gln Pro Pro Lys Ser Ile Val Asp Ala Tyr Val Leu Leu Asn Leu Gly 
            660                 665                 670         
Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Asn Ile Ala Arg 
        675                 680                 685             
Asn Ser Pro Ala Ala Arg Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg 
    690                 695                 700                 
Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn Asp Ala Val Met Ala 
705                 710                 715                 720 
Arg Gly Thr Phe Ala Asn Ile Arg Leu Leu Asn Arg Phe Leu Asn Lys 
                725                 730                 735     
Gln Ala Pro Gln Thr Ile His Leu Pro Ser Gly Glu Ile Leu Asp Val 
            740                 745                 750         
Phe Asp Ala Ala Glu Arg Tyr Gln Gln Ala Gly Leu Pro Leu Ile Val 
        755                 760                 765             
Leu Ala Gly Lys Glu Tyr Gly Ala Gly Ser Ser Arg Asp Trp Ala Ala 
    770                 775                 780                 
Lys Gly Pro Phe Leu Leu Gly Ile Lys Ala Val Leu Ala Glu Ser Tyr 
785                 790                 795                 800 
Glu Arg Ile His Arg Ser Asn Leu Val Gly Met Gly Val Ile Pro Leu 
                805                 810                 815     
Glu Tyr Leu Pro Gly Glu Asn Ala Asp Ala Leu Gly Leu Thr Gly Gln 
            820                 825                 830         
Glu Arg Tyr Thr Ile Ile Ile Pro Glu Asn Leu Lys Pro Gln Met Lys 
        835                 840                 845             
Val Gln Val Lys Leu Asp Thr Gly Lys Thr Phe Gln Ala Val Met Arg 
    850                 855                 860                 
Phe Asp Thr Asp Val Glu Leu Thr Tyr Phe Leu Asn Gly Gly Ile Leu 
865                 870                 875                 880 
Asn Tyr Met Ile Arg Lys Met Ala Lys 
                885                 

<210> 2
<211> 963
<212> PRT
<213> Homo sapiens


<220> 
<223> IRP2 isoform 1

<400> 2
Met Asp Ala Pro Lys Ala Gly Tyr Ala Phe Glu Tyr Leu Ile Glu Thr 
1               5                   10                  15      
Leu Asn Asp Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys Leu Gly 
            20                  25                  30          
Thr Lys Tyr Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ala 
        35                  40                  45              
Ala Val Arg Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp Val Met 
    50                  55                  60                  
Asn Ile Leu Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val Pro Phe 
65                  70                  75                  80  
Phe Pro Ala Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro Ala Met 
                85                  90                  95      
Val Asp Phe Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly Gly Asp 
            100                 105                 110         
Pro Glu Lys Val His Pro Ala Cys Pro Thr Asp Leu Thr Val Asp His 
        115                 120                 125             
Ser Leu Gln Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala Pro Asn 
    130                 135                 140                 
Pro Gly Gly Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro Leu Lys 
145                 150                 155                 160 
Val Gln Pro Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys Arg Gly 
                165                 170                 175     
Ser Cys Asp Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe Ser Ser 
            180                 185                 190         
Gln Ile Glu Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln Pro Val 
        195                 200                 205             
Pro Glu Pro Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe Gly Arg 
    210                 215                 220                 
Asn Arg Glu Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val Phe Lys 
225                 230                 235                 240 
Asn Val Ala Val Ile Pro Pro Gly Thr Gly Met Ala His Gln Ile Asn 
                245                 250                 255     
Leu Glu Tyr Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu Leu Phe 
            260                 265                 270         
Pro Asp Ser Val Val Gly Thr Asp Ser His Ile Thr Met Val Asn Gly 
        275                 280                 285             
Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu Ala Val 
    290                 295                 300                 
Met Leu Gly Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val Gly Cys 
305                 310                 315                 320 
Glu Leu Thr Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp Val Val 
                325                 330                 335     
Leu Gly Ile Thr Lys His Leu Arg Gln Val Gly Val Ala Gly Lys Phe 
            340                 345                 350         
Val Glu Phe Phe Gly Ser Gly Val Ser Gln Leu Ser Ile Val Asp Arg 
        355                 360                 365             
Thr Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly Ala Ile Leu Ser Phe 
    370                 375                 380                 
Phe Pro Val Asp Asn Val Thr Leu Lys His Leu Glu His Thr Gly Phe 
385                 390                 395                 400 
Ser Lys Ala Lys Leu Glu Ser Met Glu Thr Tyr Leu Lys Ala Val Lys 
                405                 410                 415     
Leu Phe Arg Asn Asp Gln Asn Ser Ser Gly Glu Pro Glu Tyr Ser Gln 
            420                 425                 430         
Val Ile Gln Ile Asn Leu Asn Ser Ile Val Pro Ser Val Ser Gly Pro 
        435                 440                 445             
Lys Arg Pro Gln Asp Arg Val Ala Val Thr Asp Met Lys Ser Asp Phe 
    450                 455                 460                 
Gln Ala Cys Leu Asn Glu Lys Val Gly Phe Lys Gly Phe Gln Ile Ala 
465                 470                 475                 480 
Ala Glu Lys Gln Lys Asp Ile Val Ser Ile His Tyr Glu Gly Ser Glu 
                485                 490                 495     
Tyr Lys Leu Ser His Gly Ser Val Val Ile Ala Ala Val Ile Ser Cys 
            500                 505                 510         
Thr Asn Asn Cys Asn Pro Ser Val Met Leu Ala Ala Gly Leu Leu Ala 
        515                 520                 525             
Lys Lys Ala Val Glu Ala Gly Leu Arg Val Lys Pro Tyr Ile Arg Thr 
    530                 535                 540                 
Ser Leu Ser Pro Gly Ser Gly Met Val Thr His Tyr Leu Ser Ser Ser 
545                 550                 555                 560 
Gly Val Leu Pro Tyr Leu Ser Lys Leu Gly Phe Glu Ile Val Gly Tyr 
                565                 570                 575     
Gly Cys Ser Ile Cys Val Gly Asn Thr Ala Pro Leu Ser Asp Ala Val 
            580                 585                 590         
Leu Asn Ala Val Lys Gln Gly Asp Leu Val Thr Cys Gly Ile Leu Ser 
        595                 600                 605             
Gly Asn Lys Asn Phe Glu Gly Arg Leu Cys Asp Cys Val Arg Ala Asn 
    610                 615                 620                 
Tyr Leu Ala Ser Pro Pro Leu Val Val Ala Tyr Ala Ile Ala Gly Thr 
625                 630                 635                 640 
Val Asn Ile Asp Phe Gln Thr Glu Pro Leu Gly Thr Asp Pro Thr Gly 
                645                 650                 655     
Lys Asn Ile Tyr Leu His Asp Ile Trp Pro Ser Arg Glu Glu Val His 
            660                 665                 670         
Arg Val Glu Glu Glu His Val Ile Leu Ser Met Phe Lys Ala Leu Lys 
        675                 680                 685             
Asp Lys Ile Glu Met Gly Asn Lys Arg Trp Asn Ser Leu Glu Ala Pro 
    690                 695                 700                 
Asp Ser Val Leu Phe Pro Trp Asp Leu Lys Ser Thr Tyr Ile Arg Cys 
705                 710                 715                 720 
Pro Ser Phe Phe Asp Lys Leu Thr Lys Glu Pro Ile Ala Leu Gln Ala 
                725                 730                 735     
Ile Glu Asn Ala His Val Leu Leu Tyr Leu Gly Asp Ser Val Thr Thr 
            740                 745                 750         
Asp His Ile Ser Pro Ala Gly Ser Ile Ala Arg Asn Ser Ala Ala Ala 
        755                 760                 765             
Lys Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg Glu Phe Asn Ser Tyr 
    770                 775                 780                 
Gly Ala Arg Arg Gly Asn Asp Ala Val Met Thr Arg Gly Thr Phe Ala 
785                 790                 795                 800 
Asn Ile Lys Leu Phe Asn Lys Phe Ile Gly Lys Pro Ala Pro Lys Thr 
                805                 810                 815     
Ile His Phe Pro Ser Gly Gln Thr Leu Asp Val Phe Glu Ala Ala Glu 
            820                 825                 830         
Leu Tyr Gln Lys Glu Gly Ile Pro Leu Ile Ile Leu Ala Gly Lys Lys 
        835                 840                 845             
Tyr Gly Ser Gly Asn Ser Arg Asp Trp Ala Ala Lys Gly Pro Tyr Leu 
    850                 855                 860                 
Leu Gly Val Lys Ala Val Leu Ala Glu Ser Tyr Glu Lys Ile His Lys 
865                 870                 875                 880 
Asp His Leu Ile Gly Ile Gly Ile Ala Pro Leu Gln Phe Leu Pro Gly 
                885                 890                 895     
Glu Asn Ala Asp Ser Leu Gly Leu Ser Gly Arg Glu Thr Phe Ser Leu 
            900                 905                 910         
Thr Phe Pro Glu Glu Leu Ser Pro Gly Ile Thr Leu Asn Ile Gln Thr 
        915                 920                 925             
Ser Thr Gly Lys Val Phe Ser Val Ile Ala Ser Phe Glu Asp Asp Val 
    930                 935                 940                 
Glu Ile Thr Leu Tyr Lys His Gly Gly Leu Leu Asn Phe Val Ala Arg 
945                 950                 955                 960 
Lys Phe Ser 
            

<210> 3
<211> 713
<212> PRT
<213> Homo sapiens


<220> 
<223> IRP2 isoform 2

<400> 3
Met Ala His Gln Ile Asn Leu Glu Tyr Leu Ser Arg Val Val Phe Glu 
1               5                   10                  15      
Glu Lys Asp Leu Leu Phe Pro Asp Ser Val Val Gly Thr Asp Ser His 
            20                  25                  30          
Ile Thr Met Val Asn Gly Leu Gly Ile Leu Gly Trp Gly Val Gly Gly 
        35                  40                  45              
Ile Glu Thr Glu Ala Val Met Leu Gly Leu Pro Val Ser Leu Thr Leu 
    50                  55                  60                  
Pro Glu Val Val Gly Cys Glu Leu Thr Gly Ser Ser Asn Pro Phe Val 
65                  70                  75                  80  
Thr Ser Ile Asp Val Val Leu Gly Ile Thr Lys His Leu Arg Gln Val 
                85                  90                  95      
Gly Val Ala Gly Lys Phe Val Glu Phe Phe Gly Ser Gly Val Ser Gln 
            100                 105                 110         
Leu Ser Ile Val Asp Arg Thr Thr Ile Ala Asn Met Cys Pro Glu Tyr 
        115                 120                 125             
Gly Ala Ile Leu Ser Phe Phe Pro Val Asp Asn Val Thr Leu Lys His 
    130                 135                 140                 
Leu Glu His Thr Gly Phe Ser Lys Ala Lys Leu Glu Ser Met Glu Thr 
145                 150                 155                 160 
Tyr Leu Lys Ala Val Lys Leu Phe Arg Asn Asp Gln Asn Ser Ser Gly 
                165                 170                 175     
Glu Pro Glu Tyr Ser Gln Val Ile Gln Ile Asn Leu Asn Ser Ile Val 
            180                 185                 190         
Pro Ser Val Ser Gly Pro Lys Arg Pro Gln Asp Arg Val Ala Val Thr 
        195                 200                 205             
Asp Met Lys Ser Asp Phe Gln Ala Cys Leu Asn Glu Lys Val Gly Phe 
    210                 215                 220                 
Lys Gly Phe Gln Ile Ala Ala Glu Lys Gln Lys Asp Ile Val Ser Ile 
225                 230                 235                 240 
His Tyr Glu Gly Ser Glu Tyr Lys Leu Ser His Gly Ser Val Val Ile 
                245                 250                 255     
Ala Ala Val Ile Ser Cys Thr Asn Asn Cys Asn Pro Ser Val Met Leu 
            260                 265                 270         
Ala Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Ala Gly Leu Arg Val 
        275                 280                 285             
Lys Pro Tyr Ile Arg Thr Ser Leu Ser Pro Gly Ser Gly Met Val Thr 
    290                 295                 300                 
His Tyr Leu Ser Ser Ser Gly Val Leu Pro Tyr Leu Ser Lys Leu Gly 
305                 310                 315                 320 
Phe Glu Ile Val Gly Tyr Gly Cys Ser Ile Cys Val Gly Asn Thr Ala 
                325                 330                 335     
Pro Leu Ser Asp Ala Val Leu Asn Ala Val Lys Gln Gly Asp Leu Val 
            340                 345                 350         
Thr Cys Gly Ile Leu Ser Gly Asn Lys Asn Phe Glu Gly Arg Leu Cys 
        355                 360                 365             
Asp Cys Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Val Ala 
    370                 375                 380                 
Tyr Ala Ile Ala Gly Thr Val Asn Ile Asp Phe Gln Thr Glu Pro Leu 
385                 390                 395                 400 
Gly Thr Asp Pro Thr Gly Lys Asn Ile Tyr Leu His Asp Ile Trp Pro 
                405                 410                 415     
Ser Arg Glu Glu Val His Arg Val Glu Glu Glu His Val Ile Leu Ser 
            420                 425                 430         
Met Phe Lys Ala Leu Lys Asp Lys Ile Glu Met Gly Asn Lys Arg Trp 
        435                 440                 445             
Asn Ser Leu Glu Ala Pro Asp Ser Val Leu Phe Pro Trp Asp Leu Lys 
    450                 455                 460                 
Ser Thr Tyr Ile Arg Cys Pro Ser Phe Phe Asp Lys Leu Thr Lys Glu 
465                 470                 475                 480 
Pro Ile Ala Leu Gln Ala Ile Glu Asn Ala His Val Leu Leu Tyr Leu 
                485                 490                 495     
Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ser Ile Ala 
            500                 505                 510         
Arg Asn Ser Ala Ala Ala Lys Tyr Leu Thr Asn Arg Gly Leu Thr Pro 
        515                 520                 525             
Arg Glu Phe Asn Ser Tyr Gly Ala Arg Arg Gly Asn Asp Ala Val Met 
    530                 535                 540                 
Thr Arg Gly Thr Phe Ala Asn Ile Lys Leu Phe Asn Lys Phe Ile Gly 
545                 550                 555                 560 
Lys Pro Ala Pro Lys Thr Ile His Phe Pro Ser Gly Gln Thr Leu Asp 
                565                 570                 575     
Val Phe Glu Ala Ala Glu Leu Tyr Gln Lys Glu Gly Ile Pro Leu Ile 
            580                 585                 590         
Ile Leu Ala Gly Lys Lys Tyr Gly Ser Gly Asn Ser Arg Asp Trp Ala 
        595                 600                 605             
Ala Lys Gly Pro Tyr Leu Leu Gly Val Lys Ala Val Leu Ala Glu Ser 
    610                 615                 620                 
Tyr Glu Lys Ile His Lys Asp His Leu Ile Gly Ile Gly Ile Ala Pro 
625                 630                 635                 640 
Leu Gln Phe Leu Pro Gly Glu Asn Ala Asp Ser Leu Gly Leu Ser Gly 
                645                 650                 655     
Arg Glu Thr Phe Ser Leu Thr Phe Pro Glu Glu Leu Ser Pro Gly Ile 
            660                 665                 670         
Thr Leu Asn Ile Gln Thr Ser Thr Gly Lys Val Phe Ser Val Ile Ala 
        675                 680                 685             
Ser Phe Glu Asp Asp Val Glu Ile Thr Leu Tyr Lys His Gly Gly Leu 
    690                 695                 700                 
Leu Asn Phe Val Ala Arg Lys Phe Ser 
705                 710             

<210> 4
<211> 906
<212> PRT
<213> Homo sapiens


<220> 
<223> IRP2 isoform 3 sequence 1

<400> 4
Met Lys Lys Glu Asp Val Met Asn Ile Leu Asp Trp Lys Thr Lys Gln 
1               5                   10                  15      
Ser Asn Val Glu Val Pro Phe Phe Pro Ala Arg Val Leu Leu Gln Asp 
            20                  25                  30          
Phe Thr Gly Ile Pro Ala Met Val Asp Phe Ala Ala Met Arg Glu Ala 
        35                  40                  45              
Val Lys Thr Leu Gly Gly Asp Pro Glu Lys Val His Pro Ala Cys Pro 
    50                  55                  60                  
Thr Asp Leu Thr Val Asp His Ser Leu Gln Ile Asp Phe Ser Lys Cys 
65                  70                  75                  80  
Ala Ile Gln Asn Ala Pro Asn Pro Gly Gly Gly Asp Leu Gln Lys Ala 
                85                  90                  95      
Gly Lys Leu Ser Pro Leu Lys Val Gln Pro Lys Lys Leu Pro Cys Arg 
            100                 105                 110         
Gly Gln Thr Thr Cys Arg Gly Ser Cys Asp Ser Gly Glu Leu Gly Arg 
        115                 120                 125             
Asn Ser Gly Thr Phe Ser Ser Gln Ile Glu Asn Thr Pro Ile Leu Cys 
    130                 135                 140                 
Pro Phe His Leu Gln Pro Val Pro Glu Pro Glu Thr Val Leu Lys Asn 
145                 150                 155                 160 
Gln Glu Val Glu Phe Gly Arg Asn Arg Glu Arg Leu Gln Phe Phe Lys 
                165                 170                 175     
Trp Ser Ser Arg Val Phe Lys Asn Val Ala Val Ile Pro Pro Gly Thr 
            180                 185                 190         
Gly Met Ala His Gln Ile Asn Leu Glu Tyr Leu Ser Arg Val Val Phe 
        195                 200                 205             
Glu Glu Lys Asp Leu Leu Phe Pro Asp Ser Val Val Gly Thr Asp Ser 
    210                 215                 220                 
His Ile Thr Met Val Asn Gly Leu Gly Ile Leu Gly Trp Gly Val Gly 
225                 230                 235                 240 
Gly Ile Glu Thr Glu Ala Val Met Leu Gly Leu Pro Val Ser Leu Thr 
                245                 250                 255     
Leu Pro Glu Val Val Gly Cys Glu Leu Thr Gly Ser Ser Asn Pro Phe 
            260                 265                 270         
Val Thr Ser Ile Asp Val Val Leu Gly Ile Thr Lys His Leu Arg Gln 
        275                 280                 285             
Val Gly Val Ala Gly Lys Phe Val Glu Phe Phe Gly Ser Gly Val Ser 
    290                 295                 300                 
Gln Leu Ser Ile Val Asp Arg Thr Thr Ile Ala Asn Met Cys Pro Glu 
305                 310                 315                 320 
Tyr Gly Ala Ile Leu Ser Phe Phe Pro Val Asp Asn Val Thr Leu Lys 
                325                 330                 335     
His Leu Glu His Thr Gly Phe Ser Lys Ala Lys Leu Glu Ser Met Glu 
            340                 345                 350         
Thr Tyr Leu Lys Ala Val Lys Leu Phe Arg Asn Asp Gln Asn Ser Ser 
        355                 360                 365             
Gly Glu Pro Glu Tyr Ser Gln Val Ile Gln Ile Asn Leu Asn Ser Ile 
    370                 375                 380                 
Val Pro Ser Val Ser Gly Pro Lys Arg Pro Gln Asp Arg Val Ala Val 
385                 390                 395                 400 
Thr Asp Met Lys Ser Asp Phe Gln Ala Cys Leu Asn Glu Lys Val Gly 
                405                 410                 415     
Phe Lys Gly Phe Gln Ile Ala Ala Glu Lys Gln Lys Asp Ile Val Ser 
            420                 425                 430         
Ile His Tyr Glu Gly Ser Glu Tyr Lys Leu Ser His Gly Ser Val Val 
        435                 440                 445             
Ile Ala Ala Val Ile Ser Cys Thr Asn Asn Cys Asn Pro Ser Val Met 
    450                 455                 460                 
Leu Ala Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Ala Gly Leu Arg 
465                 470                 475                 480 
Val Lys Pro Tyr Ile Arg Thr Ser Leu Ser Pro Gly Ser Gly Met Val 
                485                 490                 495     
Thr His Tyr Leu Ser Ser Ser Gly Val Leu Pro Tyr Leu Ser Lys Leu 
            500                 505                 510         
Gly Phe Glu Ile Val Gly Tyr Gly Cys Ser Ile Cys Val Gly Asn Thr 
        515                 520                 525             
Ala Pro Leu Ser Asp Ala Val Leu Asn Ala Val Lys Gln Gly Asp Leu 
    530                 535                 540                 
Val Thr Cys Gly Ile Leu Ser Gly Asn Lys Asn Phe Glu Gly Arg Leu 
545                 550                 555                 560 
Cys Asp Cys Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Val 
                565                 570                 575     
Ala Tyr Ala Ile Ala Gly Thr Val Asn Ile Asp Phe Gln Thr Glu Pro 
            580                 585                 590         
Leu Gly Thr Asp Pro Thr Gly Lys Asn Ile Tyr Leu His Asp Ile Trp 
        595                 600                 605             
Pro Ser Arg Glu Glu Val His Arg Val Glu Glu Glu His Val Ile Leu 
    610                 615                 620                 
Ser Met Phe Lys Ala Leu Lys Asp Lys Ile Glu Met Gly Asn Lys Arg 
625                 630                 635                 640 
Trp Asn Ser Leu Glu Ala Pro Asp Ser Val Leu Phe Pro Trp Asp Leu 
                645                 650                 655     
Lys Ser Thr Tyr Ile Arg Cys Pro Ser Phe Phe Asp Lys Leu Thr Lys 
            660                 665                 670         
Glu Pro Ile Ala Leu Gln Ala Ile Glu Asn Ala His Val Leu Leu Tyr 
        675                 680                 685             
Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ser Ile 
    690                 695                 700                 
Ala Arg Asn Ser Ala Ala Ala Lys Tyr Leu Thr Asn Arg Gly Leu Thr 
705                 710                 715                 720 
Pro Arg Glu Phe Asn Ser Tyr Gly Ala Arg Arg Gly Asn Asp Ala Val 
                725                 730                 735     
Met Thr Arg Gly Thr Phe Ala Asn Ile Lys Leu Phe Asn Lys Phe Ile 
            740                 745                 750         
Gly Lys Pro Ala Pro Lys Thr Ile His Phe Pro Ser Gly Gln Thr Leu 
        755                 760                 765             
Asp Val Phe Glu Ala Ala Glu Leu Tyr Gln Lys Glu Gly Ile Pro Leu 
    770                 775                 780                 
Ile Ile Leu Ala Gly Lys Lys Tyr Gly Ser Gly Asn Ser Arg Asp Trp 
785                 790                 795                 800 
Ala Ala Lys Gly Pro Tyr Leu Leu Gly Val Lys Ala Val Leu Ala Glu 
                805                 810                 815     
Ser Tyr Glu Lys Ile His Lys Asp His Leu Ile Gly Ile Gly Ile Ala 
            820                 825                 830         
Pro Leu Gln Phe Leu Pro Gly Glu Asn Ala Asp Ser Leu Gly Leu Ser 
        835                 840                 845             
Gly Arg Glu Thr Phe Ser Leu Thr Phe Pro Glu Glu Leu Ser Pro Gly 
    850                 855                 860                 
Ile Thr Leu Asn Ile Gln Thr Ser Thr Gly Lys Val Phe Ser Val Ile 
865                 870                 875                 880 
Ala Ser Phe Glu Asp Asp Val Glu Ile Thr Leu Tyr Lys His Gly Gly 
                885                 890                 895     
Leu Leu Asn Phe Val Ala Arg Lys Phe Ser 
            900                 905     

<210> 5
<211> 906
<212> PRT
<213> Homo sapiens


<220> 
<223> IRP2 isoform 3 sequence 2

<400> 5
Met Lys Lys Glu Asp Val Met Asn Ile Leu Asp Trp Lys Thr Lys Gln 
1               5                   10                  15      
Ser Asn Val Glu Val Pro Phe Phe Pro Ala Arg Val Leu Leu Gln Asp 
            20                  25                  30          
Phe Thr Gly Ile Pro Ala Met Val Asp Phe Ala Ala Met Arg Glu Ala 
        35                  40                  45              
Val Lys Thr Leu Gly Gly Asp Pro Glu Lys Val His Pro Ala Cys Pro 
    50                  55                  60                  
Thr Asp Leu Thr Val Asp His Ser Leu Gln Ile Asp Phe Ser Lys Cys 
65                  70                  75                  80  
Ala Ile Gln Asn Ala Pro Asn Pro Gly Gly Gly Asp Leu Gln Lys Ala 
                85                  90                  95      
Gly Lys Leu Ser Pro Leu Lys Val Gln Pro Lys Lys Leu Pro Cys Arg 
            100                 105                 110         
Gly Gln Thr Thr Cys Arg Gly Ser Cys Asp Ser Gly Glu Leu Gly Arg 
        115                 120                 125             
Asn Ser Gly Thr Phe Ser Ser Gln Ile Glu Asn Thr Pro Ile Leu Cys 
    130                 135                 140                 
Pro Phe His Leu Gln Pro Val Pro Glu Pro Glu Thr Val Leu Lys Asn 
145                 150                 155                 160 
Gln Glu Val Glu Phe Gly Arg Asn Arg Glu Arg Leu Gln Phe Phe Lys 
                165                 170                 175     
Trp Ser Ser Arg Val Phe Lys Asn Val Ala Val Ile Pro Pro Gly Thr 
            180                 185                 190         
Gly Met Ala His Gln Ile Asn Leu Glu Tyr Leu Ser Arg Val Val Phe 
        195                 200                 205             
Glu Glu Lys Asp Leu Leu Phe Pro Asp Ser Val Val Gly Thr Asp Ser 
    210                 215                 220                 
His Ile Thr Met Val Asn Gly Leu Gly Ile Leu Gly Trp Gly Val Gly 
225                 230                 235                 240 
Gly Ile Glu Thr Glu Ala Val Met Leu Gly Leu Pro Val Ser Leu Thr 
                245                 250                 255     
Leu Pro Glu Val Val Gly Cys Glu Leu Thr Gly Ser Ser Asn Pro Phe 
            260                 265                 270         
Val Thr Ser Ile Asp Val Val Leu Gly Ile Thr Lys His Leu Arg Gln 
        275                 280                 285             
Val Gly Val Ala Gly Lys Phe Val Glu Phe Phe Gly Ser Gly Val Ser 
    290                 295                 300                 
Gln Leu Ser Ile Val Asp Arg Thr Thr Ile Ala Asn Met Cys Pro Glu 
305                 310                 315                 320 
Tyr Gly Ala Ile Leu Ser Phe Phe Pro Val Asp Asn Val Thr Leu Lys 
                325                 330                 335     
His Leu Glu His Thr Gly Phe Ser Lys Ala Lys Leu Glu Ser Met Glu 
            340                 345                 350         
Thr Tyr Leu Lys Ala Val Lys Leu Phe Arg Asn Asp Gln Asn Ser Ser 
        355                 360                 365             
Gly Glu Pro Glu Tyr Ser Gln Val Ile Gln Ile Asn Leu Asn Ser Ile 
    370                 375                 380                 
Val Pro Ser Val Ser Gly Pro Lys Arg Pro Gln Asp Arg Val Ala Val 
385                 390                 395                 400 
Thr Asp Met Lys Ser Asp Phe Gln Ala Cys Leu Asn Glu Lys Val Gly 
                405                 410                 415     
Phe Lys Gly Phe Gln Ile Ala Ala Glu Lys Gln Lys Asp Ile Val Ser 
            420                 425                 430         
Ile His Tyr Glu Gly Ser Glu Tyr Lys Leu Ser His Gly Ser Val Val 
        435                 440                 445             
Ile Ala Ala Val Ile Ser Cys Thr Asn Asn Cys Asn Pro Ser Val Met 
    450                 455                 460                 
Leu Ala Ala Gly Leu Leu Ala Lys Lys Ala Val Glu Ala Gly Leu Arg 
465                 470                 475                 480 
Val Lys Pro Tyr Ile Arg Thr Ser Leu Ser Pro Gly Ser Gly Met Val 
                485                 490                 495     
Thr His Tyr Leu Ser Ser Ser Gly Val Leu Pro Tyr Leu Ser Lys Leu 
            500                 505                 510         
Gly Phe Glu Ile Val Gly Tyr Gly Cys Ser Thr Cys Val Gly Asn Thr 
        515                 520                 525             
Ala Pro Leu Ser Asp Ala Val Leu Asn Ala Val Lys Gln Gly Asp Leu 
    530                 535                 540                 
Val Thr Cys Gly Ile Leu Ser Gly Asn Lys Asn Phe Glu Gly Arg Leu 
545                 550                 555                 560 
Cys Asp Cys Val Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Val 
                565                 570                 575     
Ala Tyr Ala Ile Ala Gly Thr Val Asn Ile Asp Phe Gln Thr Glu Pro 
            580                 585                 590         
Leu Gly Thr Asp Pro Thr Gly Lys Asn Ile Tyr Leu His Asp Ile Trp 
        595                 600                 605             
Pro Ser Arg Glu Glu Val His Arg Val Glu Glu Glu His Val Ile Leu 
    610                 615                 620                 
Ser Met Phe Lys Ala Leu Lys Asp Lys Ile Glu Met Gly Asn Lys Arg 
625                 630                 635                 640 
Trp Asn Ser Leu Glu Ala Pro Asp Ser Val Leu Phe Pro Trp Asp Leu 
                645                 650                 655     
Lys Ser Thr Tyr Ile Arg Cys Pro Ser Phe Phe Asp Lys Leu Thr Lys 
            660                 665                 670         
Glu Pro Ile Ala Leu Gln Ala Ile Glu Asn Ala His Val Leu Leu Tyr 
        675                 680                 685             
Leu Gly Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Ser Ile 
    690                 695                 700                 
Ala Arg Asn Ser Ala Ala Ala Lys Tyr Leu Thr Asn Arg Gly Leu Thr 
705                 710                 715                 720 
Pro Arg Glu Phe Asn Ser Tyr Gly Ala Arg Arg Gly Asn Asp Ala Val 
                725                 730                 735     
Met Thr Arg Gly Thr Phe Ala Asn Ile Lys Leu Phe Asn Lys Phe Ile 
            740                 745                 750         
Gly Lys Pro Ala Pro Lys Thr Ile His Phe Pro Ser Gly Gln Thr Leu 
        755                 760                 765             
Asp Val Phe Glu Ala Ala Glu Leu Tyr Gln Lys Glu Gly Ile Pro Leu 
    770                 775                 780                 
Ile Ile Leu Ala Gly Lys Lys Tyr Gly Ser Gly Asn Ser Arg Asp Trp 
785                 790                 795                 800 
Ala Ala Lys Gly Pro Tyr Leu Leu Gly Val Lys Ala Val Leu Ala Glu 
                805                 810                 815     
Ser Tyr Glu Lys Ile His Lys Asp His Leu Ile Gly Ile Gly Ile Ala 
            820                 825                 830         
Pro Leu Gln Phe Leu Pro Gly Glu Asn Ala Asp Ser Leu Gly Leu Ser 
        835                 840                 845             
Gly Arg Glu Thr Phe Ser Leu Thr Phe Pro Glu Glu Leu Ser Pro Gly 
    850                 855                 860                 
Ile Thr Leu Asn Ile Gln Thr Ser Thr Gly Lys Val Phe Ser Val Ile 
865                 870                 875                 880 
Ala Ser Phe Glu Asp Asp Val Glu Ile Thr Leu Tyr Lys His Gly Gly 
                885                 890                 895     
Leu Leu Asn Phe Val Ala Arg Lys Phe Ser 
            900                 905     

<210> 6
<211> 343
<212> PRT
<213> Homo sapiens


<220> 
<223> IRP2 isoform 4

<400> 6
Met Asp Ala Pro Lys Ala Gly Tyr Ala Phe Glu Tyr Leu Ile Glu Thr 
1               5                   10                  15      
Leu Asn Asp Ser Ser His Lys Lys Phe Phe Asp Val Ser Lys Leu Gly 
            20                  25                  30          
Thr Lys Tyr Asp Val Leu Pro Tyr Ser Ile Arg Val Leu Leu Glu Ala 
        35                  40                  45              
Ala Val Arg Asn Cys Asp Gly Phe Leu Met Lys Lys Glu Asp Val Met 
    50                  55                  60                  
Asn Ile Leu Asp Trp Lys Thr Lys Gln Ser Asn Val Glu Val Pro Phe 
65                  70                  75                  80  
Phe Pro Ala Arg Val Leu Leu Gln Asp Phe Thr Gly Ile Pro Ala Met 
                85                  90                  95      
Val Asp Phe Ala Ala Met Arg Glu Ala Val Lys Thr Leu Gly Gly Asp 
            100                 105                 110         
Pro Glu Lys Val His Pro Ala Cys Pro Thr Asp Leu Thr Val Asp His 
        115                 120                 125             
Ser Leu Gln Ile Asp Phe Ser Lys Cys Ala Ile Gln Asn Ala Pro Asn 
    130                 135                 140                 
Pro Gly Gly Gly Asp Leu Gln Lys Ala Gly Lys Leu Ser Pro Leu Lys 
145                 150                 155                 160 
Val Gln Pro Lys Lys Leu Pro Cys Arg Gly Gln Thr Thr Cys Arg Gly 
                165                 170                 175     
Ser Cys Asp Ser Gly Glu Leu Gly Arg Asn Ser Gly Thr Phe Ser Ser 
            180                 185                 190         
Gln Ile Glu Asn Thr Pro Ile Leu Cys Pro Phe His Leu Gln Pro Val 
        195                 200                 205             
Pro Glu Pro Glu Thr Val Leu Lys Asn Gln Glu Val Glu Phe Gly Arg 
    210                 215                 220                 
Asn Arg Glu Arg Leu Gln Phe Phe Lys Trp Ser Ser Arg Val Phe Lys 
225                 230                 235                 240 
Asn Val Ala Val Ile Pro Pro Gly Thr Gly Met Ala His Gln Ile Asn 
                245                 250                 255     
Leu Glu Tyr Leu Ser Arg Val Val Phe Glu Glu Lys Asp Leu Leu Phe 
            260                 265                 270         
Pro Asp Ser Val Val Gly Thr Asp Ser His Ile Thr Met Val Asn Gly 
        275                 280                 285             
Leu Gly Ile Leu Gly Trp Gly Val Gly Gly Ile Glu Thr Glu Ala Val 
    290                 295                 300                 
Met Leu Gly Leu Pro Val Ser Leu Thr Leu Pro Glu Val Val Gly Cys 
305                 310                 315                 320 
Glu Leu Thr Gly Ser Ser Asn Pro Phe Val Thr Ser Ile Asp Val Val 
                325                 330                 335     
Leu Gly Ile Thr Lys Val Ser 
            340             

<210> 7
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> T2A peptide

<400> 7
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      
Gly Pro 

