                         SEQUENCE LISTING

<110>  National Institute of Chemistry
 
<120>  Coiled-coil mediated tethering of CRISPR/CAS and exonucleases for 
       enhanced genome editing

<130>  69116P WO

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  4308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-P4

<400>  1
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctctagcc cggaagataa aattgctcag ctgaaacaaa aaatccaagc gctgaaacag     4260

gaaaaccagc agctggaaga ggaaaacgcc gcactggaat atggttaa                  4308


<210>  2
<211>  4308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-P3

<400>  2
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctcttccc cggaagatga gatccagcaa ctggaagaag aaatcgctca gctggaacag     4260

aaaaacgcag cgctgaaaga gaaaaaccag gcgctgaaat acggttaa                  4308


<210>  3
<211>  4293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-N5

<400>  3
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctctgaga tcgccgccct ggaggccaag atcgccgccc tgaaggccaa gaacgccgcc     4260

ctgaaggccg agatcgccgc cctggaggcc taa                                  4293


<210>  4
<211>  4293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-N6

<400>  4
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctctaaga tcgccgccct gaaggccgag atcgccgccc tggaggccga gaacgccgcc     4260

ctggaggcca agatcgccgc cctgaaggcc taa                                  4293


<210>  5
<211>  4305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-P3S

<400>  5
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctctagcc ccgaggacga gatccagcag ctggaggagg agatcagcca gctggagcag     4260

aagaacagcc agctgaagga gaagaaccag cagctgaagt actaa                     4305


<210>  6
<211>  4305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-P4S

<400>  6
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctctagcc ccgaggacaa gatcagccag ctgaagcaga agatccagca gctgaagcag     4260

gagaaccagc agctggagga ggagaacagc cagctggagt actaa                     4305


<210>  7
<211>  4305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9-AP4

<400>  7
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag       60

tacagcatcg gcctggacat cggcaccaac tctgtgggct gggccgtgat caccgacgag      120

tacaaggtgc ccagcaagaa attcaaggtg ctgggcaaca ccgaccggca cagcatcaag      180

aagaacctga tcggagccct gctgttcgac agcggcgaaa cagccgaggc cacccggctg      240

aagagaaccg ccagaagaag atacaccaga cggaagaacc ggatctgcta tctgcaagag      300

atcttcagca acgagatggc caaggtggac gacagcttct tccacagact ggaagagtcc      360

ttcctggtgg aagaggataa gaagcacgag cggcacccca tcttcggcaa catcgtggac      420

gaggtggcct accacgagaa gtaccccacc atctaccacc tgagaaagaa actggtggac      480

agcaccgaca aggccgacct gcggctgatc tatctggccc tggcccacat gatcaagttc      540

cggggccact tcctgatcga gggcgacctg aaccccgaca acagcgacgt ggacaagctg      600

ttcatccagc tggtgcagac ctacaaccag ctgttcgagg aaaaccccat caacgccagc      660

ggcgtggacg ccaaggccat cctgtctgcc agactgagca agagcagacg gctggaaaat      720

ctgatcgccc agctgcccgg cgagaagaag aatggcctgt tcggaaacct gattgccctg      780

agcctgggcc tgacccccaa cttcaagagc aacttcgacc tggccgagga tgccaaactg      840

cagctgagca aggacaccta cgacgacgac ctggacaacc tgctggccca gatcggcgac      900

cagtacgccg acctgtttct ggccgccaag aacctgtccg acgccatcct gctgagcgac      960

atcctgagag tgaacaccga gatcaccaag gcccccctga gcgcctctat gatcaagaga     1020

tacgacgagc accaccagga cctgaccctg ctgaaagctc tcgtgcggca gcagctgcct     1080

gagaagtaca aagagatttt cttcgaccag agcaagaacg gctacgccgg ctacattgac     1140

ggcggagcca gccaggaaga gttctacaag ttcatcaagc ccatcctgga aaagatggac     1200

ggcaccgagg aactgctcgt gaagctgaac agagaggacc tgctgcggaa gcagcggacc     1260

ttcgacaacg gcagcatccc ccaccagatc cacctgggag agctgcacgc cattctgcgg     1320

cggcaggaag atttttaccc attcctgaag gacaaccggg aaaagatcga gaagatcctg     1380

accttccgca tcccctacta cgtgggccct ctggccaggg gaaacagcag attcgcctgg     1440

atgaccagaa agagcgagga aaccatcacc ccctggaact tcgaggaagt ggtggacaag     1500

ggcgcttccg cccagagctt catcgagcgg atgaccaact tcgataagaa cctgcccaac     1560

gagaaggtgc tgcccaagca cagcctgctg tacgagtact tcaccgtgta taacgagctg     1620

accaaagtga aatacgtgac cgagggaatg agaaagcccg ccttcctgag cggcgagcag     1680

aaaaaggcca tcgtggacct gctgttcaag accaaccgga aagtgaccgt gaagcagctg     1740

aaagaggact acttcaagaa aatcgagtgc ttcgactccg tggaaatctc cggcgtggaa     1800

gatcggttca acgcctccct gggcacatac cacgatctgc tgaaaattat caaggacaag     1860

gacttcctgg acaatgagga aaacgaggac attctggaag atatcgtgct gaccctgaca     1920

ctgtttgagg acagagagat gatcgaggaa cggctgaaaa cctatgccca cctgttcgac     1980

gacaaagtga tgaagcagct gaagcggcgg agatacaccg gctggggcag gctgagccgg     2040

aagctgatca acggcatccg ggacaagcag tccggcaaga caatcctgga tttcctgaag     2100

tccgacggct tcgccaacag aaacttcatg cagctgatcc acgacgacag cctgaccttt     2160

aaagaggaca tccagaaagc ccaggtgtcc ggccagggcg atagcctgca cgagcacatt     2220

gccaatctgg ccggcagccc cgccattaag aagggcatcc tgcagacagt gaaggtggtg     2280

gacgagctcg tgaaagtgat gggccggcac aagcccgaga acatcgtgat cgaaatggcc     2340

agagagaacc agaccaccca gaagggacag aagaacagcc gcgagagaat gaagcggatc     2400

gaagagggca tcaaagagct gggcagccag atcctgaaag aacaccccgt ggaaaacacc     2460

cagctgcaga acgagaagct gtacctgtac tacctgcaga atgggcggga tatgtacgtg     2520

gaccaggaac tggacatcaa ccggctgtcc gactacgatg tggaccatat cgtgcctcag     2580

agctttctga aggacgactc catcgacaac aaggtgctga ccagaagcga caagaaccgg     2640

ggcaagagcg acaacgtgcc ctccgaagag gtcgtgaaga agatgaagaa ctactggcgg     2700

cagctgctga acgccaagct gattacccag agaaagttcg acaatctgac caaggccgag     2760

agaggcggcc tgagcgaact ggataaggcc ggcttcatca agagacagct ggtggaaacc     2820

cggcagatca caaagcacgt ggcacagatc ctggactccc ggatgaacac taagtacgac     2880

gagaatgaca agctgatccg ggaagtgaaa gtgatcaccc tgaagtccaa gctggtgtcc     2940

gatttccgga aggatttcca gttttacaaa gtgcgcgaga tcaacaacta ccaccacgcc     3000

cacgacgcct acctgaacgc cgtcgtggga accgccctga tcaaaaagta ccctaagctg     3060

gaaagcgagt tcgtgtacgg cgactacaag gtgtacgacg tgcggaagat gatcgccaag     3120

agcgagcagg aaatcggcaa ggctaccgcc aagtacttct tctacagcaa catcatgaac     3180

tttttcaaga ccgagattac cctggccaac ggcgagatcc ggaagcggcc tctgatcgag     3240

acaaacggcg aaaccgggga gatcgtgtgg gataagggcc gggattttgc caccgtgcgg     3300

aaagtgctga gcatgcccca agtgaatatc gtgaaaaaga ccgaggtgca gacaggcggc     3360

ttcagcaaag agtctatcct gcccaagagg aacagcgata agctgatcgc cagaaagaag     3420

gactgggacc ctaagaagta cggcggcttc gacagcccca ccgtggccta ttctgtgctg     3480

gtggtggcca aagtggaaaa gggcaagtcc aagaaactga agagtgtgaa agagctgctg     3540

gggatcacca tcatggaaag aagcagcttc gagaagaatc ccatcgactt tctggaagcc     3600

aagggctaca aagaagtgaa aaaggacctg atcatcaagc tgcctaagta ctccctgttc     3660

gagctggaaa acggccggaa gagaatgctg gcctctgccg gcgaactgca gaagggaaac     3720

gaactggccc tgccctccaa atatgtgaac ttcctgtacc tggccagcca ctatgagaag     3780

ctgaagggct cccccgagga taatgagcag aaacagctgt ttgtggaaca gcacaagcac     3840

tacctggacg agatcatcga gcagatcagc gagttctcca agagagtgat cctggccgac     3900

gctaatctgg acaaagtgct gtccgcctac aacaagcacc gggataagcc catcagagag     3960

caggccgaga atatcatcca cctgtttacc ctgaccaatc tgggagcccc tgccgccttc     4020

aagtactttg acaccaccat cgaccggaag aggtacacca gcaccaaaga ggtgctggac     4080

gccaccctga tccaccagag catcaccggc ctgtacgaga cacggatcga cctgtctcag     4140

ctgggaggcg acgatccaaa aaagaagaga aaggtaggcg gctctggcgg cggctccgga     4200

ggctctagcc ccgaggacga gctggccgcc aacgaggagg agctgcagca gaacgagcag     4260

aagctggccc agatcaagca gaagctgcag gccatcaagt actaa                     4305


<210>  8
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P4-EXOIII

<400>  8
agcccggaag ataaaattgc tcagctgaaa caaaaaatcc aagcgctgaa acaggaaaac       60

cagcagctgg aagaggaaaa cgccgcactg gaatatggtg gcggctctgg cggcggctcc      120

ggaggctctg atccaaaaaa gaagagaaag gtaaaatttg tctcttttaa tatcaacggc      180

ctgcgcgcca gacctcacca gcttgaagcc atcgtcgaaa agcaccaacc ggatgtgatt      240

ggcctgcagg agacaaaagt tcatgacgat atgtttccgc tcgaagaggt ggcgaagctc      300

ggctacaacg tgttttatca cgggcagaaa ggccattatg gcgtggcgct gctgaccaaa      360

gagacgccga ttgccgtgcg tcgcggcttt cccggtgacg acgaagaggc gcagcggcgg      420

attattatgg cggaaatccc ctcactgctg ggtaatgtca ccgtgatcaa cggttacttc      480

ccgcagggtg aaagccgcga ccatccgata aaattcccgg caaaagcgca gttttatcag      540

aatctgcaaa actacctgga aaccgaactc aaacgtgata atccggtact gattatgggc      600

gatatgaata tcagccctac agatctggac atcggcattg gcgaagaaaa ccgtaagcgc      660

tggctgcgta ccggtaaatg ctctttcctg ccggaagagc gcgaatggat ggacaggctg      720

atgagctggg ggttggtcga taccttccgc catgcgaatc cgcaaacagc agatcgtttc      780

tcatggtttg attaccgctc aaaaggtttt gacgataacc gtggtctgcg catcgacctg      840

ctgctcgcca gccaaccgct ggcagaatgt tgcgtagaaa ccggcatcga ctatgaaatc      900

cgcagcatgg aaaaaccgtc cgatcacgcc cccgtctggg cgaccttccg ccgctaa         957


<210>  9
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P3-EXOIII

<400>  9
tccccggaag atgagatcca gcaactggaa gaagaaatcg ctcagctgga acagaaaaac       60

gcagcgctga aagagaaaaa ccaggcgctg aaatacggtg gcggctctgg cggcggctcc      120

ggaggctctg atccaaaaaa gaagagaaag gtaaaatttg tctcttttaa tatcaacggc      180

ctgcgcgcca gacctcacca gcttgaagcc atcgtcgaaa agcaccaacc ggatgtgatt      240

ggcctgcagg agacaaaagt tcatgacgat atgtttccgc tcgaagaggt ggcgaagctc      300

ggctacaacg tgttttatca cgggcagaaa ggccattatg gcgtggcgct gctgaccaaa      360

gagacgccga ttgccgtgcg tcgcggcttt cccggtgacg acgaagaggc gcagcggcgg      420

attattatgg cggaaatccc ctcactgctg ggtaatgtca ccgtgatcaa cggttacttc      480

ccgcagggtg aaagccgcga ccatccgata aaattcccgg caaaagcgca gttttatcag      540

aatctgcaaa actacctgga aaccgaactc aaacgtgata atccggtact gattatgggc      600

gatatgaata tcagccctac agatctggac atcggcattg gcgaagaaaa ccgtaagcgc      660

tggctgcgta ccggtaaatg ctctttcctg ccggaagagc gcgaatggat ggacaggctg      720

atgagctggg ggttggtcga taccttccgc catgcgaatc cgcaaacagc agatcgtttc      780

tcatggtttg attaccgctc aaaaggtttt gacgataacc gtggtctgcg catcgacctg      840

ctgctcgcca gccaaccgct ggcagaatgt tgcgtagaaa ccggcatcga ctatgaaatc      900

cgcagcatgg aaaaaccgtc cgatcacgcc cccgtctggg cgaccttccg ccgctaa         957


<210>  10
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N5-EXOIII

<400>  10
gagatcgccg ccctggaggc caagatcgcc gccctgaagg ccaagaacgc cgccctgaag       60

gccgagatcg ccgccctgga ggccggcggc tctggcggcg gctccggagg ctctgatcca      120

aaaaagaaga gaaaggtaaa atttgtctct tttaatatca acggcctgcg cgccagacct      180

caccagcttg aagccatcgt cgaaaagcac caaccggatg tgattggcct gcaggagaca      240

aaagttcatg acgatatgtt tccgctcgaa gaggtggcga agctcggcta caacgtgttt      300

tatcacgggc agaaaggcca ttatggcgtg gcgctgctga ccaaagagac gccgattgcc      360

gtgcgtcgcg gctttcccgg tgacgacgaa gaggcgcagc ggcggattat tatggcggaa      420

atcccctcac tgctgggtaa tgtcaccgtg atcaacggtt acttcccgca gggtgaaagc      480

cgcgaccatc cgataaaatt cccggcaaaa gcgcagtttt atcagaatct gcaaaactac      540

ctggaaaccg aactcaaacg tgataatccg gtactgatta tgggcgatat gaatatcagc      600

cctacagatc tggacatcgg cattggcgaa gaaaaccgta agcgctggct gcgtaccggt      660

aaatgctctt tcctgccgga agagcgcgaa tggatggaca ggctgatgag ctgggggttg      720

gtcgatacct tccgccatgc gaatccgcaa acagcagatc gtttctcatg gtttgattac      780

cgctcaaaag gttttgacga taaccgtggt ctgcgcatcg acctgctgct cgccagccaa      840

ccgctggcag aatgttgcgt agaaaccggc atcgactatg aaatccgcag catggaaaaa      900

ccgtccgatc acgcccccgt ctgggcgacc ttccgccgc                             939


<210>  11
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N6-EXOIII

<400>  11
aagatcgccg ccctgaaggc cgagatcgcc gccctggagg ccgagaacgc cgccctggag       60

gccaagatcg ccgccctgaa ggccggcggc tctggcggcg gctccggagg ctctgatcca      120

aaaaagaaga gaaaggtaaa atttgtctct tttaatatca acggcctgcg cgccagacct      180

caccagcttg aagccatcgt cgaaaagcac caaccggatg tgattggcct gcaggagaca      240

aaagttcatg acgatatgtt tccgctcgaa gaggtggcga agctcggcta caacgtgttt      300

tatcacgggc agaaaggcca ttatggcgtg gcgctgctga ccaaagagac gccgattgcc      360

gtgcgtcgcg gctttcccgg tgacgacgaa gaggcgcagc ggcggattat tatggcggaa      420

atcccctcac tgctgggtaa tgtcaccgtg atcaacggtt acttcccgca gggtgaaagc      480

cgcgaccatc cgataaaatt cccggcaaaa gcgcagtttt atcagaatct gcaaaactac      540

ctggaaaccg aactcaaacg tgataatccg gtactgatta tgggcgatat gaatatcagc      600

cctacagatc tggacatcgg cattggcgaa gaaaaccgta agcgctggct gcgtaccggt      660

aaatgctctt tcctgccgga agagcgcgaa tggatggaca ggctgatgag ctgggggttg      720

gtcgatacct tccgccatgc gaatccgcaa acagcagatc gtttctcatg gtttgattac      780

cgctcaaaag gttttgacga taaccgtggt ctgcgcatcg acctgctgct cgccagccaa      840

ccgctggcag aatgttgcgt agaaaccggc atcgactatg aaatccgcag catggaaaaa      900

ccgtccgatc acgcccccgt ctgggcgacc ttccgccgc                             939


<210>  12
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P3S-EXOIII

<400>  12
agccccgagg acgagatcca gcagctggag gaggagatca gccagctgga gcagaagaac       60

agccagctga aggagaagaa ccagcagctg aagtacggcg gctctggcgg cggctccgga      120

ggctctgatc caaaaaagaa gagaaaggta aaatttgtct cttttaatat caacggcctg      180

cgcgccagac ctcaccagct tgaagccatc gtcgaaaagc accaaccgga tgtgattggc      240

ctgcaggaga caaaagttca tgacgatatg tttccgctcg aagaggtggc gaagctcggc      300

tacaacgtgt tttatcacgg gcagaaaggc cattatggcg tggcgctgct gaccaaagag      360

acgccgattg ccgtgcgtcg cggctttccc ggtgacgacg aagaggcgca gcggcggatt      420

attatggcgg aaatcccctc actgctgggt aatgtcaccg tgatcaacgg ttacttcccg      480

cagggtgaaa gccgcgacca tccgataaaa ttcccggcaa aagcgcagtt ttatcagaat      540

ctgcaaaact acctggaaac cgaactcaaa cgtgataatc cggtactgat tatgggcgat      600

atgaatatca gccctacaga tctggacatc ggcattggcg aagaaaaccg taagcgctgg      660

ctgcgtaccg gtaaatgctc tttcctgccg gaagagcgcg aatggatgga caggctgatg      720

agctgggggt tggtcgatac cttccgccat gcgaatccgc aaacagcaga tcgtttctca      780

tggtttgatt accgctcaaa aggttttgac gataaccgtg gtctgcgcat cgacctgctg      840

ctcgccagcc aaccgctggc agaatgttgc gtagaaaccg gcatcgacta tgaaatccgc      900

agcatggaaa aaccgtccga tcacgccccc gtctgggcga ccttccgccg c               951


<210>  13
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P4S-EXOIII

<400>  13
agccccgagg acaagatcag ccagctgaag cagaagatcc agcagctgaa gcaggagaac       60

cagcagctgg aggaggagaa cagccagctg gagtacggcg gctctggcgg cggctccgga      120

ggctctgatc caaaaaagaa gagaaaggta aaatttgtct cttttaatat caacggcctg      180

cgcgccagac ctcaccagct tgaagccatc gtcgaaaagc accaaccgga tgtgattggc      240

ctgcaggaga caaaagttca tgacgatatg tttccgctcg aagaggtggc gaagctcggc      300

tacaacgtgt tttatcacgg gcagaaaggc cattatggcg tggcgctgct gaccaaagag      360

acgccgattg ccgtgcgtcg cggctttccc ggtgacgacg aagaggcgca gcggcggatt      420

attatggcgg aaatcccctc actgctgggt aatgtcaccg tgatcaacgg ttacttcccg      480

cagggtgaaa gccgcgacca tccgataaaa ttcccggcaa aagcgcagtt ttatcagaat      540

ctgcaaaact acctggaaac cgaactcaaa cgtgataatc cggtactgat tatgggcgat      600

atgaatatca gccctacaga tctggacatc ggcattggcg aagaaaaccg taagcgctgg      660

ctgcgtaccg gtaaatgctc tttcctgccg gaagagcgcg aatggatgga caggctgatg      720

agctgggggt tggtcgatac cttccgccat gcgaatccgc aaacagcaga tcgtttctca      780

tggtttgatt accgctcaaa aggttttgac gataaccgtg gtctgcgcat cgacctgctg      840

ctcgccagcc aaccgctggc agaatgttgc gtagaaaccg gcatcgacta tgaaatccgc      900

agcatggaaa aaccgtccga tcacgccccc gtctgggcga ccttccgccg c               951


<210>  14
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AP4-EXOIII

<400>  14
agccccgagg acgagctggc cgccaacgag gaggagctgc agcagaacga gcagaagctg       60

gcccagatca agcagaagct gcaggccatc aagtacggcg gctctggcgg cggctccgga      120

ggctctgatc caaaaaagaa gagaaaggta aaatttgtct cttttaatat caacggcctg      180

cgcgccagac ctcaccagct tgaagccatc gtcgaaaagc accaaccgga tgtgattggc      240

ctgcaggaga caaaagttca tgacgatatg tttccgctcg aagaggtggc gaagctcggc      300

tacaacgtgt tttatcacgg gcagaaaggc cattatggcg tggcgctgct gaccaaagag      360

acgccgattg ccgtgcgtcg cggctttccc ggtgacgacg aagaggcgca gcggcggatt      420

attatggcgg aaatcccctc actgctgggt aatgtcaccg tgatcaacgg ttacttcccg      480

cagggtgaaa gccgcgacca tccgataaaa ttcccggcaa aagcgcagtt ttatcagaat      540

ctgcaaaact acctggaaac cgaactcaaa cgtgataatc cggtactgat tatgggcgat      600

atgaatatca gccctacaga tctggacatc ggcattggcg aagaaaaccg taagcgctgg      660

ctgcgtaccg gtaaatgctc tttcctgccg gaagagcgcg aatggatgga caggctgatg      720

agctgggggt tggtcgatac cttccgccat gcgaatccgc aaacagcaga tcgtttctca      780

tggtttgatt accgctcaaa aggttttgac gataaccgtg gtctgcgcat cgacctgctg      840

ctcgccagcc aaccgctggc agaatgttgc gtagaaaccg gcatcgacta tgaaatccgc      900

agcatggaaa aaccgtccga tcacgccccc gtctgggcga ccttccgccg c               951


<210>  15
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P3-TREX2

<400>  15
tccccggaag atgagatcca gcaactggaa gaagaaatcg ctcagctgga acagaaaaac       60

gcagcgctga aagagaaaaa ccaggcgctg aaatacggtg gcggctctgg cggcggctcc      120

ggaggctcta tgtctgagcc acctcgggct gagacctttg tattcctgga cctagaagcc      180

actgggctcc caaacatgga ccctgagatt gcagagatat ccctttttgc tgttcaccgc      240

tcttccctgg agaacccaga acgggatgat tctggttcct tggtgctgcc ccgtgttctg      300

gacaagctca cactgtgcat gtgcccggag cgccccttta ctgccaaggc cagtgagatt      360

actggtttga gcagcgaaag cctgatgcac tgcgggaagg ctggtttcaa tggcgctgtg      420

gtaaggacac tgcagggctt cctaagccgc caggagggcc ccatctgcct tgtggcccac      480

aatggcttcg attatgactt cccactgctg tgcacggagc tacaacgtct gggtgcccat      540

ctgccccaag acactgtctg cctggacaca ctgcctgcat tgcggggcct ggaccgtgct      600

cacagccacg gcaccagggc tcaaggccgc aaaagctaca gcctggccag tctcttccac      660

cgctacttcc aggctgaacc cagtgctgcc cattcagcag aaggtgatgt gcacaccctg      720

cttctgatct tcctgcatcg tgctcctgag ctgctcgcct gggcagatga gcaggcccgc      780

agctgggctc atattgagcc catgtacgtg ccacctgatg gtccaagcct cgaagcctga      840


<210>  16
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P4-TREX2

<400>  16
agcccggaag ataaaattgc tcagctgaaa caaaaaatcc aagcgctgaa acaggaaaac       60

cagcagctgg aagaggaaaa cgccgcactg gaatatggtg gcggctctgg cggcggctcc      120

ggaggctctt ctgagccacc tcgggctgag acctttgtat tcctggacct agaagccact      180

gggctcccaa acatggaccc tgagattgca gagatatccc tttttgctgt tcaccgctct      240

tccctggaga acccagaacg ggatgattct ggttccttgg tgctgccccg tgttctggac      300

aagctcacac tgtgcatgtg cccggagcgc ccctttactg ccaaggccag tgagattact      360

ggtttgagca gcgaaagcct gatgcactgc gggaaggctg gtttcaatgg cgctgtggta      420

aggacactgc agggcttcct aagccgccag gagggcccca tctgccttgt ggcccacaat      480

ggcttcgatt atgacttccc actgctgtgc acggagctac aacgtctggg tgcccatctg      540

ccccaagaca ctgtctgcct ggacacactg cctgcattgc ggggcctgga ccgtgctcac      600

agccacggca ccagggctca aggccgcaaa agctacagcc tggccagtct cttccaccgc      660

tacttccagg ctgaacccag tgctgcccat tcagcagaag gtgatgtgca caccctgctt      720

ctgatcttcc tgcatcgtgc tcctgagctg ctcgcctggg cagatgagca ggcccgcagc      780

tgggctcata ttgagcccat gtacgtgcca cctgatggtc caagcctcga agcctga         837


<210>  17
<211>  2668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P3-EXO1

<400>  17
tccccggaag atgagatcca gcaactggaa gaagaaatcg ctcagctgga acagaaaaac       60

gcagcgctga aagagaaaaa ccaggcgctg aaatacggtg gcggctctgg cggcggctcc      120

ggaggctctg cgatcgccat ggggatacag ggattgctac aatttatcaa agaagcttca      180

gaacccatcc atgtgaggaa gtataaaggg caggtagtag ctgtggatac atattgctgg      240

cttcacaaag gagctattgc ttgtgctgaa aaactagcca aaggtgaacc tactgatagg      300

tatgtaggat tttgtatgaa atttgtaaat atgttactat ctcatgggat caagcctatt      360

ctcgtatttg atggatgtac tttaccttct aaaaaggaag tagagagatc tagaagagaa      420

agacgacaag ccaatcttct taagggaaag caacttcttc gtgaggggaa agtctcggaa      480

gctcgagagt gtttcacccg gtctatcaat atcacacatg ccatggccca caaagtaatt      540

aaagctgccc ggtctcaggg ggtagattgc ctcgtggctc cctatgaagc tgatgcgcag      600

ttggcctatc ttaacaaagc gggaattgtg caagccataa ttacagagga ctcggatctc      660

ctagcttttg gctgtaaaaa ggtaatttta aagatggacc agtttggaaa tggacttgaa      720

attgatcaag ctcggctagg aatgtgcaga cagcttgggg atgtattcac ggaagagaag      780

tttcgttaca tgtgtattct ttcaggttgt gactacctgt catcactgcg tgggattgga      840

ttagcaaagg catgcaaagt cctaagacta gccaataatc cagatatagt aaaggttatc      900

aagaaaattg gacattatct caagatgaat atcacggtac cagaggatta catcaacggg      960

tttattcggg ccaacaatac cttcctctat cagctagttt ttgatcccat caaaaggaaa     1020

cttattcctc tgaacgccta tgaagatgat gttgatcctg aaacactaag ctacgctggg     1080

caatatgttg atgattccat agctcttcaa atagcacttg gaaataaaga tataaatact     1140

tttgaacaga tcgatgacta caatccagac actgctatgc ctgcccattc aagaagtcat     1200

agttgggatg acaaaacatg tcaaaagtca gctaatgtta gcagcatttg gcataggaat     1260

tactctccca gaccagagtc gggtactgtt tcagatgccc cacaattgaa ggaaaatcca     1320

agtactgtgg gagtggaacg agtgattagt actaaagggt taaatctccc aaggaaatca     1380

tccattgtga aaagaccaag aagtgcagag ctgtcagaag atgacctgtt gagtcagtat     1440

tctctttcat ttacgaagaa gaccaagaaa aatagctctg aaggcaataa atcattgagc     1500

ttttctgaag tgtttgtgcc tgacctggta aatggaccta ctaacaaaaa gagtgtaagc     1560

actccaccta ggacgagaaa taaatttgca acatttttac aaaggaaaaa tgaagaaagt     1620

ggtgcagttg tggttccagg gaccagaagc aggttttttt gcagttcaga ttctactgac     1680

tgtgtatcaa acaaagtgag catccagcct ctggatgaaa ctgctgtcac agataaagag     1740

aacaatctgc atgaatcaga gtatggagac caagaaggca agagactggt tgacacagat     1800

gtagcacgta attcaagtga tgacattccg aataatcata ttccaggtga tcatattcca     1860

gacaaggcaa cagtgtttac agatgaagag tcctactctt ttgagagcag caaatttaca     1920

aggaccattt caccacccac tttgggaaca ctaagaagtt gttttagttg gtctggaggt     1980

cttggagatt tttcaagaac gccgagcccc tctccaagca cagcattgca gcagttccga     2040

agaaagagcg attcccccac ctctttgcct gagaataata tgtctgatgt gtcgcagtta     2100

aagagcgagg agtccagtga cgatgagtct catcccttac gagaaggggc atgttcttca     2160

cagtcccagg aaagtggaga attctcactg cagagttcaa atgcatcaaa gctttctcag     2220

tgctctagta aggactctga ttcagaggaa tctgattgca atattaagtt acttgacagt     2280

caaagtgacc agacctccaa gctatgttta tctcatttct caaaaaaaga cacacctcta     2340

aggaacaagg ttcctgggct atataagtcc agttctgcag actctctttc tacaaccaag     2400

atcaaacctc taggacctgc cagagccagt gggctgagca agaagccggc aagcatccag     2460

aagagaaagc atcataatgc cgagaacaag ccggggttac agatcaaact caatgagctc     2520

tggaaaaact ttggatttaa aaaagattct gaaaagcttc ctccttgtaa gaaacccctg     2580

tccccagtca gagataacat ccaactaact ccagaagcgg aagaggatat atttaacaaa     2640

cctgaatgtg gccgtgttca aagagcaa                                        2668


<210>  18
<211>  2668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P4-EXO1

<400>  18
agcccggaag ataaaattgc tcagctgaaa caaaaaatcc aagcgctgaa acaggaaaac       60

cagcagctgg aagaggaaaa cgccgcactg gaatatggtg gcggctctgg cggcggctcc      120

ggaggctctg cgatcgccat ggggatacag ggattgctac aatttatcaa agaagcttca      180

gaacccatcc atgtgaggaa gtataaaggg caggtagtag ctgtggatac atattgctgg      240

cttcacaaag gagctattgc ttgtgctgaa aaactagcca aaggtgaacc tactgatagg      300

tatgtaggat tttgtatgaa atttgtaaat atgttactat ctcatgggat caagcctatt      360

ctcgtatttg atggatgtac tttaccttct aaaaaggaag tagagagatc tagaagagaa      420

agacgacaag ccaatcttct taagggaaag caacttcttc gtgaggggaa agtctcggaa      480

gctcgagagt gtttcacccg gtctatcaat atcacacatg ccatggccca caaagtaatt      540

aaagctgccc ggtctcaggg ggtagattgc ctcgtggctc cctatgaagc tgatgcgcag      600

ttggcctatc ttaacaaagc gggaattgtg caagccataa ttacagagga ctcggatctc      660

ctagcttttg gctgtaaaaa ggtaatttta aagatggacc agtttggaaa tggacttgaa      720

attgatcaag ctcggctagg aatgtgcaga cagcttgggg atgtattcac ggaagagaag      780

tttcgttaca tgtgtattct ttcaggttgt gactacctgt catcactgcg tgggattgga      840

ttagcaaagg catgcaaagt cctaagacta gccaataatc cagatatagt aaaggttatc      900

aagaaaattg gacattatct caagatgaat atcacggtac cagaggatta catcaacggg      960

tttattcggg ccaacaatac cttcctctat cagctagttt ttgatcccat caaaaggaaa     1020

cttattcctc tgaacgccta tgaagatgat gttgatcctg aaacactaag ctacgctggg     1080

caatatgttg atgattccat agctcttcaa atagcacttg gaaataaaga tataaatact     1140

tttgaacaga tcgatgacta caatccagac actgctatgc ctgcccattc aagaagtcat     1200

agttgggatg acaaaacatg tcaaaagtca gctaatgtta gcagcatttg gcataggaat     1260

tactctccca gaccagagtc gggtactgtt tcagatgccc cacaattgaa ggaaaatcca     1320

agtactgtgg gagtggaacg agtgattagt actaaagggt taaatctccc aaggaaatca     1380

tccattgtga aaagaccaag aagtgcagag ctgtcagaag atgacctgtt gagtcagtat     1440

tctctttcat ttacgaagaa gaccaagaaa aatagctctg aaggcaataa atcattgagc     1500

ttttctgaag tgtttgtgcc tgacctggta aatggaccta ctaacaaaaa gagtgtaagc     1560

actccaccta ggacgagaaa taaatttgca acatttttac aaaggaaaaa tgaagaaagt     1620

ggtgcagttg tggttccagg gaccagaagc aggttttttt gcagttcaga ttctactgac     1680

tgtgtatcaa acaaagtgag catccagcct ctggatgaaa ctgctgtcac agataaagag     1740

aacaatctgc atgaatcaga gtatggagac caagaaggca agagactggt tgacacagat     1800

gtagcacgta attcaagtga tgacattccg aataatcata ttccaggtga tcatattcca     1860

gacaaggcaa cagtgtttac agatgaagag tcctactctt ttgagagcag caaatttaca     1920

aggaccattt caccacccac tttgggaaca ctaagaagtt gttttagttg gtctggaggt     1980

cttggagatt tttcaagaac gccgagcccc tctccaagca cagcattgca gcagttccga     2040

agaaagagcg attcccccac ctctttgcct gagaataata tgtctgatgt gtcgcagtta     2100

aagagcgagg agtccagtga cgatgagtct catcccttac gagaaggggc atgttcttca     2160

cagtcccagg aaagtggaga attctcactg cagagttcaa atgcatcaaa gctttctcag     2220

tgctctagta aggactctga ttcagaggaa tctgattgca atattaagtt acttgacagt     2280

caaagtgacc agacctccaa gctatgttta tctcatttct caaaaaaaga cacacctcta     2340

aggaacaagg ttcctgggct atataagtcc agttctgcag actctctttc tacaaccaag     2400

atcaaacctc taggacctgc cagagccagt gggctgagca agaagccggc aagcatccag     2460

aagagaaagc atcataatgc cgagaacaag ccggggttac agatcaaact caatgagctc     2520

tggaaaaact ttggatttaa aaaagattct gaaaagcttc ctccttgtaa gaaacccctg     2580

tccccagtca gagataacat ccaactaact ccagaagcgg aagaggatat atttaacaaa     2640

cctgaatgtg gccgtgttca aagagcaa                                        2668


<210>  19
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  targeting sequence in eGFP genomic region

<400>  19
ggcgagggcg atgccaccta                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human EMX1 gene targeting sequence

<400>  20
gagtccgagc agaagaagaa                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human VEGF gene targeting sequence

<400>  21
ggtgagtgag tgtgtgcgtg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human MYD88 gene targeting sequence

<400>  22
ggctgagaag cctttacagg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human ANKRD52 gene targeting sequence

<400>  23
actgtaaagg ctgctctccc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human FUT9 gene target sequence

<400>  24
tgcagaggag cctttacatg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human PSKH2 gene targeting sequence

<400>  25
gccagacaag gctttacagg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  human BCR-ABL fusion gene targeting sequence

<400>  26
gacctgtctt ttagacaggc                                                   20


<210>  27
<211>  40
<212>  DNA
<213>  artificial sequence

<220>
<223>  equivalent Cas9 protein expression - pcDNA3

<400>  27
ggaggctgag aagcctttac aggtggccgc tgtagacagc                             40


<210>  28
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  equivalent Cas9 protein expression - Cas9

<400>  28
ggaggctgag aaggtggccg ctgtagacag c                                      31


<210>  29
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  equivalent Cas9 protein expression - Cas9+EXO3

<400>  29
ggaggcaggt ggccgctgta gacagc                                            26