                         б

<110>  ͲҽҩϺι˾
 
<120>  һֿCD47ԭϵ׼Ӧ

<130>  0113-PA-012

<160>  198   

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808ɱ

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  2
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807ɱ

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  4
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811PR001280PR001281ɱ

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811PR001280PR001281

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805ɱ

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Asn Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  8
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Asn Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  9
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001279ɱ

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Asn Thr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  10
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001279

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Asn Thr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  11
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001277ɱ

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Gln Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  12
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001277

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Gln Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  13
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001278ɱ

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  14
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001278

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  15
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000804PR001266PR001267PR001268PR001269PR001
       275PR001276ɱ

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  16
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000804PR001266PR001267PR001268PR001269PR001
       275PR001276

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Ser Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  17
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001271ɱ

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  18
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001271

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Asn Thr Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  19
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001270PR001272ɱ

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Gln Ser Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  20
<211>  215
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001270PR001272

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Arg Gln Tyr Gln Ser Tyr Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  21
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803ɱ

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  22
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Ser Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  23
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001274ɱ

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Thr Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  24
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001274

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Asn Thr Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  25
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001273ɱ

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  26
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001273

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Gln Ser Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  27
<211>  106
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806ɱ

<400>  27

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ser Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Asn Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  28
<211>  213
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ser Ser Ser Leu Asp Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Asn Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  29
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265ɱ

<400>  29

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ile Arg Ala Thr Asp Ile Pro Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Leu Tyr Asn Tyr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  30
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265

<400>  30

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser His 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ile Arg Ala Thr Asp Ile Pro Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Leu Tyr Asn Tyr Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  31
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265LCDR2KabatChothiaCombined

<400>  31

Gly Ala Ser Ile Arg Ala Thr 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001264HCDR1Chothia

<400>  32

Gly Asp Ser Val Asp Thr Tyr 
1               5           


<210>  33
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001264HCDR1Combined

<400>  33

Gly Asp Ser Val Asp Thr Tyr Tyr Trp Thr 
1               5                   10  


<210>  34
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796HCDR1Chothia

<400>  34

Gly Asp Ser Val Asn Thr Tyr 
1               5           


<210>  35
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796HCDR1Combined

<400>  35

Gly Asp Ser Val Asn Thr Tyr Tyr Trp Thr 
1               5                   10  


<210>  36
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001265HCDR1Chothia

<400>  36

Gly Asp Ser Val Gln Thr Tyr 
1               5           


<210>  37
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001265HCDR1Combined

<400>  37

Gly Asp Ser Val Gln Thr Tyr Tyr Trp Thr 
1               5                   10  


<210>  38
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808HCDR1Chothia

<400>  38

Gly Gly Ser Ile Asp Asn Tyr 
1               5           


<210>  39
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808HCDR1Combined

<400>  39

Gly Gly Ser Ile Asp Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  40
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR001268

       PR001269PR001270

PR001271HCDRChothia

<400>  40

Gly Gly Ser Ile Asn Asn Tyr 
1               5           


<210>  41
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR001268

       PR001269PR001270

PR001271HCDRCombined

<400>  41

Gly Gly Ser Ile Asn Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  42
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR000806PR000807PR001266PR001267PR001272PR001
       277PR001278PR001279HCDRChothia

<400>  42

Gly Gly Ser Ile Ser Asn Tyr 
1               5           


<210>  43
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR000806PR001266PR001267PR001272PR001277PR001
       278PR001279HCDR1Combined

<400>  43

Gly Gly Ser Ile Ser Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807HCDR1(Combined)

<400>  44

Gly Gly Ser Ile Ser Asn Tyr Tyr Trp Thr 
1               5                   10  


<210>  45
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000804PR001275PR001276HCDR1Chothia

<400>  45

Gly Gly Ser Ile Ser Ser Tyr 
1               5           


<210>  46
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000804PR001275PR001276HCDR1Combined

<400>  46

Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
1               5                   10  


<210>  47
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274HCDR1Chothia

<400>  47

Gly Gly Ser Ile Ser Thr Tyr 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274HCDR1Combined

<400>  48

Gly Gly Ser Ile Ser Thr Tyr Tyr Trp Ser 
1               5                   10  


<210>  49
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  49

<400>  49

Gly Gly Ser Leu Asn Asn Tyr 
1               5           


<210>  50
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811HCDR1(Combined)

<400>  50

Gly Gly Ser Leu Asn Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  51
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001280HCDR1(Chothia)

<400>  51

Gly Gly Ser Leu Gln Asn Tyr 
1               5           


<210>  52
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001280HCDR1(Combined)

<400>  52

Gly Gly Ser Leu Gln Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  53
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001281HCDR1(Chothia)

<400>  53

Gly Gly Ser Leu Ser Asn Tyr 
1               5           


<210>  54
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001281HCDR1(Combined)

<400>  54

Gly Gly Ser Leu Ser Asn Tyr Tyr Trp Ser 
1               5                   10  


<210>  55
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808HCDR3(KabatChothiaCombined)

<400>  55

Gly Arg Trp Gly Ser Tyr 
1               5       


<210>  56
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000804PR000805PR000811PR001266PR001267PR001
       268PR001269PR001270PR001271PR001272PR001275PR001276
       PR001277PR001278PR001279PR001280PR001281LCDR2KabatC
       hothiaCombined

<400>  56

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274LCDR2ChothiaKabatCombined

<400>  57

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265HCDR3ChothiaKabatCombined

<400>  58

Lys Lys Leu Ile Phe Asp Tyr 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806HCDR3ChothiaKabatCombined

<400>  59

Lys Arg Ala Met Tyr Asp Tyr 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000804PR000805PR001266PR001267PR001268PR001
       269PR001270PR001271PR001272PR001275PR001276PR001277
       PR001278PR001279HCDR3KabatChothiaCombined

<400>  60

Lys Arg Gly Val Leu Asp Tyr 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807HCDR3KabatChothiaCombined

<400>  61

Lys Arg Thr Ala Phe Asp Tyr 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274HCDR3ChothiaKabatCombined

<400>  62

Lys Arg Thr Val His Asp Tyr 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811PR001280PR001281HCDR3ChothiaKabatCombined

<400>  63

Lys Arg Trp Gly Phe Asp Tyr 
1               5           


<210>  64
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808HCDR2KabatCombined

<400>  64

Asn Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  65
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000805PR000806PR000808PR000811PR001266PR001
       267PR001268PR001269PR001270PR001271PR001272PR001277
       PR001278PR001279PR001280PR001281HCDR1Kabat

<400>  65

Asn Tyr Tyr Trp Ser 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807HCDR1(Kabat)

<400>  66

Asn Tyr Tyr Trp Thr 
1               5   


<210>  67
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803LCDR3KabatChothiaCombined

<400>  67

Gln His Tyr Asn Ser Tyr Tyr Thr 
1               5               


<210>  68
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001274LCDR3KabatChothiaCombined

<400>  68

Gln His Tyr Asn Thr Tyr Tyr Thr 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001273LCDR3KabatChothiaCombined

<400>  69

Gln His Tyr Gln Ser Tyr Tyr Thr 
1               5               


<210>  70
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265LCDR3ChothiaKabatCombined

<400>  70

Gln Leu Tyr Asn Tyr Trp Pro Leu Thr 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807LCDR3KabatChothiaCombined

<400>  71

Gln Gln Ser Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808LCDR3KabatChothiaCombined

<400>  72

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  73
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806LCDR3KabatChothiaCombined

<400>  73

Gln Gln Tyr Ile Asn Tyr Tyr Thr 
1               5               


<210>  74
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811PR001280PR001281LCDR3KabatChothiaCombined

<400>  74

Gln Gln Tyr Asn Ser Tyr Ser Tyr Thr 
1               5                   


<210>  75
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807ɱ

<400>  75

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  76
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807

<400>  76

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Val Thr Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  77
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR001277PR001278PR001279ɱ

<400>  77

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  78
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR001277PR001278PR001279

<400>  78

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  79
<211>  114
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808ɱ

<400>  79

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asp Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Gly Arg Trp Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  80
<211>  441
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808

<400>  80

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asp Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Gly 
                85                  90                  95      


Arg Gly Arg Trp Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440     


<210>  81
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001268ɱ

<400>  81

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  82
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001268

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  83
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001269ɱ

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  84
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001269

<400>  84

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  85
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR001270PR001271ɱ

<400>  85

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  86
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR001270PR001271

<400>  86

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  87
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806ɱ

<400>  87

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Ile Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Ile Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Ala Met Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  88
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806

<400>  88

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Ile Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Ile Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Ala Met Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  89
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001266PR001272ɱ

<400>  89

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  90
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001266PR001272

<400>  90

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  91
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001267ɱ

<400>  91

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  92
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001267

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  93
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001276ɱ

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  94
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001276

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  95
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000804ɱ

<400>  95

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Ser Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  96
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000804

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Ser Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  97
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001275ɱ

<400>  97

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Gln Ser Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  98
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001275

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Gln Ser Ser Leu Thr 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Gly Val Leu Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  99
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274ɱ

<400>  99

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Thr Val His Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  100
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Thr Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Thr Val His Asp Tyr Trp Gly Gln Gly Ile Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  101
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811ɱ

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Gly Phe Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  102
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Asn Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Gly Phe Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  103
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001280ɱ

<400>  103

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Gln Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Gly Phe Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  104
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001280

<400>  104

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Gln Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Gly Phe Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  105
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001281ɱ

<400>  105

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Gly Phe Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  106
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001281

<400>  106

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Leu Ser Asn Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Arg Trp Gly Phe Asp Tyr Ser Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  107
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001264ɱ

<400>  107

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Asp Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Lys Leu Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  108
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001264

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Asp Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Lys Leu Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  109
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796ɱ

<400>  109

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Asn Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Lys Leu Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  110
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Asn Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Lys Leu Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  111
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001265ɱ

<400>  111

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Gln Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Lys Leu Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  112
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001265

<400>  112

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Val Gln Thr Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ser Ala Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Lys Lys Leu Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


<210>  113
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802-806PR000811 
       PR001266-1281LCDR1KabatChothiaCombined

<400>  113

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  114
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807PR000808LCDR1KabatChothiaCombined

<400>  114

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  115
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265LCDR1KabatChothiaCombined

<400>  115

Arg Ala Ser Gln Ser Val Ser Ser His Leu Ala 
1               5                   10      


<210>  116
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000804PR001266-1269PR001275-1276LCDR3KabatC
       hothiaCombined

<400>  116

Arg Gln Tyr Asn Ser Tyr Ser Pro Tyr Thr 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805LCDR3KabatChothiaCombined

<400>  117

Arg Gln Tyr Asn Thr Asn Ser Pro Tyr Thr 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001279LCDR3KabatChothiaCombined

<400>  118

Arg Gln Tyr Asn Thr Asn Thr Pro Tyr Thr 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001277LCDR3KabatChothiaCombined

<400>  119

Arg Gln Tyr Asn Thr Gln Ser Pro Tyr Thr 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001271PR001278LCDR3KabatChothiaCombined

<400>  120

Arg Gln Tyr Asn Thr Tyr Ser Pro Tyr Thr 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001270PR001272LCDR3KabatChothiaCombined

<400>  121

Arg Gln Tyr Gln Ser Tyr Ser Pro Tyr Thr 
1               5                   10  


<210>  122
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806LCDR2KabatChothiaCombined

<400>  122

Arg Ser Ser Ser Leu Asp Ser 
1               5           


<210>  123
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000804PR001275PR001276HCDR1Kabat

<400>  123

Ser Tyr Tyr Trp Ser 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274HCDR1Kabat

<400>  124

Thr Tyr Tyr Trp Ser 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265HCDR1Kabat

<400>  125

Thr Tyr Tyr Trp Thr 
1               5   


<210>  126
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808LCDR2KabatChothiaCombined

<400>  126

Val Ala Ser Arg Leu Gln Ser 
1               5           


<210>  127
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807LCDR2KabatChothiaCombined

<400>  127

Val Ala Ser Ser Leu Gln Ser 
1               5           


<210>  128
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001266,PR001268,PR001272HCDR2KabatCombined

<400>  128

Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  129
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802,PR001267,PR001269,PR001270,PR001271HCDR2KabatCombi
       ned

<400>  129

Tyr Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Ser Ser Leu Lys Ser 
1               5                   10                  15      


<210>  130
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803,PR000811,PR001273,PR001274,PR001280,PR001281HCDR2Kab
       atCombined

<400>  130

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  131
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807HCDR2KabatCombined

<400>  131

Tyr Ile Tyr Tyr Ser Gly Thr Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  132
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR0007963,PR000805,PR000806,PR001264,PR001265,PR001277,PR001278,P
       R001279HCDR2KabatCombined

<400>  132

Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  133
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001276HCDR2KabatCombined

<400>  133

Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Pro Ser Leu Thr Ser 
1               5                   10                  15      


<210>  134
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000804HCDR2KabatCombined

<400>  134

Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Asn Ser Ser Leu Thr Ser 
1               5                   10                  15      


<210>  135
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001275HCDR2(KabatCombined)

<400>  135

Tyr Ile Tyr Tyr Ser Gly Thr Thr Asn Tyr Gln Ser Ser Leu Thr Ser 
1               5                   10                  15      


<210>  136
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR001266PR001267PR001268PR001269PR001270PR001
       271HCDR2 (Chothia)

<400>  136

Tyr Tyr Ser Gly Asn 
1               5   


<210>  137
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR000811PR001273PR001274PR001281HCDR2(Chothia)

<400>  137

Tyr Tyr Ser Gly Ser 
1               5   


<210>  138
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR000804-808126412651275-1279HCDR2(Chothia)

<400>  138

Tyr Tyr Ser Gly Thr 
1               5   


<210>  139
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1 ͨʽ


<220>
<221>  X
<222>  (6)..(6)
<223>  X=IV

<220>
<221>  X
<222>  (9)..(9)
<223>  X=W,YH

<220>
<221>  X
<222>  (11)..(11)
<223>  X=AN

<400>  139

Arg Ala Ser Gln Ser Xaa Ser Ser Xaa Leu Xaa 
1               5                   10      


<210>  140
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2 ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=K,R,VG

<220>
<221>  X
<222>  (2)..(2)
<223>  X2=AS

<220>
<221>  X
<222>  (4)..(4)
<223>  X3=S,T,RI

<220>
<221>  X
<222>  (5)..(5)
<223>  X4=LR

<220>
<221>  X
<222>  (6)..(6)
<223>  X=E,D,QA

<220>
<221>  X
<222>  (7)..(7)
<223>  X=ST

<400>  140

Xaa Xaa Ser Xaa Xaa Xaa Xaa 
1               5           


<210>  141
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3 ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=QR

<220>
<221>  X
<222>  (2)..(2)
<223>  X=Q,LH

<220>
<221>  X
<222>  (3)..(3)
<223>  X=Y-

<220>
<221>  X
<222>  (4)..(4)
<223>  X=N,I,Q-

<220>
<221>  X
<222>  (5)..(5)
<223>  X=S,Y,TN

<220>
<221>  X
<222>  (6)..(6)
<223>  X=Y,W,NQ

<220>
<221>  X
<222>  (7)..(7)
<223>  X=S,T-

<220>
<221>  X
<222>  (8)..(8)
<223>  X=T-

<220>
<221>  X
<222>  (9)..(9)
<223>  X=P-

<220>
<221>  X
<222>  (10)..(10)
<223>  X=Y,RL

<400>  141

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr 
1               5                   10      


<210>  142
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1ͨʽ


<220>
<221>  X
<222>  (2)..(2)
<223>  X=GD

<220>
<221>  X
<222>  (4)..(4)
<223>  X=I,LV

<220>
<221>  X
<222>  (5)..(5)
<223>  X=S,N,DQ

<220>
<221>  X
<222>  (6)..(6)
<223>  X=N,S

<220>
<221>  X
<222>  (6)..(6)
<223>  X=N,ST

<400>  142

Gly Xaa Ser Xaa Xaa Xaa Tyr 
1               5           


<210>  143
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ͨʽ


<220>
<221>  X
<222>  (5)..(5)
<223>  X=T,NS

<400>  143

Tyr Tyr Ser Gly Xaa 
1               5   


<210>  144
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=KG

<220>
<221>  X
<222>  (2)..(2)
<223>  X=RK

<220>
<221>  X
<222>  (3)..(3)
<223>  X=G,A,T,WL

<220>
<221>  X
<222>  (4)..(4)
<223>  X=V,M,G,IA

<220>
<221>  X
<222>  (5)..(5)
<223>  X=L,Y,H,F-

<220>
<221>  X
<222>  (6)..(6)
<223>  X=DS

<400>  144

Xaa Xaa Xaa Xaa Xaa Xaa Tyr 
1               5           


<210>  145
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ


<220>
<221>  X
<222>  (12)..(12)
<223>  X=VM

<220>
<221>  X
<222>  (13)..(13)
<223>  X=KQ

<220>
<221>  X
<222>  (23)..(23)
<223>  X=TS

<400>  145

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Xaa Xaa Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Xaa Val Ser 
            20                  25  


<210>  146
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ


<220>
<221>  X
<222>  (3)..(3)
<223>  X=ST

<220>
<221>  X
<222>  (5)..(5)
<223>  X=IF

<220>
<221>  X
<222>  (8)..(8)
<223>  X=PA

<220>
<221>  X
<222>  (11)..(11)
<223>  X=KR

<220>
<221>  X
<222>  (18)..(18)
<223>  X=YN

<400>  146

Tyr Trp Xaa Trp Xaa Arg Gln Xaa Pro Gly Xaa Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Xaa Ile 
            


<210>  147
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽ


<220>
<221>  X
<222>  (2)..(2)
<223>  X=ND

<220>
<221>  X
<222>  (4)..(4)
<223>  X=NQ

<220>
<221>  X
<222>  (5)..(5)
<223>  X=PS

<220>
<221>  X
<222>  (8)..(8)
<223>  X=KT

<220>
<221>  X
<222>  (12)..(12)
<223>  X=TS

<220>
<221>  X
<222>  (13)..(13)
<223>  X=IM

<220>
<221>  X
<222>  (15)..(15)
<223>  X=VI

<220>
<221>  X
<222>  (17)..(17)
<223>  X=TI

<220>
<221>  X
<222>  (25)..(25)
<223>  X=KN

<220>
<221>  X
<222>  (27)..(27)
<223>  X=S,TN

<220>
<221>  X
<222>  (30)..(30)
<223>  X=TI

<220>
<221>  X
<222>  (31)..(31)
<223>  X=AS

<220>
<221>  X
<222>  (32)..(32)
<223>  X=AG

<220>
<221>  X
<222>  (36)..(36)
<223>  X=VM

<220>
<221>  X
<222>  (40)..(40)
<223>  X=AG

<400>  147

Thr Xaa Tyr Xaa Xaa Ser Leu Xaa Ser Arg Val Xaa Xaa Ser Xaa Asp 
1               5                   10                  15      


Xaa Ser Lys Asn Gln Phe Ser Leu Xaa Leu Xaa Ser Val Xaa Xaa Xaa 
            20                  25                  30          


Asp Thr Ala Xaa Tyr Tyr Cys Xaa Arg 
        35                  40      


<210>  148
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=WS

<220>
<221>  X
<222>  (5)..(5)
<223>  X=TI

<400>  148

Xaa Gly Gln Gly Xaa Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  149
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=DE

<220>
<221>  X
<222>  (3)..(3)
<223>  X=QV

<220>
<221>  X
<222>  (9)..(9)
<223>  X=SA

<220>
<221>  X
<222>  (10)..(10)
<223>  X=TS

<220>
<221>  X
<222>  (13)..(13)
<223>  X=AV

<220>
<221>  X
<222>  (15)..(15)
<223>  X=VP

<220>
<221>  X
<222>  (17)..(17)
<223>  X=DE

<220>
<221>  X
<222>  (19)..(19)
<223>  X=VA

<220>
<221>  X
<222>  (21)..(21)
<223>  X=IL

<220>
<221>  X
<222>  (22)..(22)
<223>  X=TS

<400>  149

Xaa Ile Xaa Met Thr Gln Ser Pro Xaa Xaa Leu Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Xaa Thr Xaa Xaa Cys 
            20              


<210>  150
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽ


<220>
<221>  X
<222>  (8)..(8)
<223>  X=KNQ

<220>
<221>  X
<222>  (11)..(11)
<223>  X=KR

<400>  150

Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Xaa Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  151
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=GD

<220>
<221>  X
<222>  (2)..(2)
<223>  X=VI

<220>
<221>  X
<222>  (4)..(4)
<223>  X=SV

<220>
<221>  X
<222>  (14)..(14)
<223>  X=ED

<220>
<221>  X
<222>  (16)..(16)
<223>  X=TS

<220>
<221>  X
<222>  (19)..(19)
<223>  X=IV

<220>
<221>  X
<222>  (24)..(24)
<223>  X=PS

<220>
<221>  X
<222>  (25)..(25)
<223>  X=DE

<220>
<221>  X
<222>  (29)..(29)
<223>  X=TI

<400>  151

Xaa Xaa Pro Xaa Arg Phe Ser Gly Ser Gly Ser Gly Thr Xaa Phe Xaa 
1               5                   10                  15      


Leu Thr Xaa Ser Ser Leu Gln Xaa Xaa Asp Phe Ala Xaa Tyr Tyr Cys 
            20                  25                  30          


<210>  152
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽ


<220>
<221>  X
<222>  (3)..(3)
<223>  X=QG

<220>
<221>  X
<222>  (7)..(7)
<223>  X=LV

<400>  152

Phe Gly Xaa Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  153
<211>  109
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=DE

<220>
<221>  X
<222>  (3)..(3)
<223>  X=QV

<220>
<221>  X
<222>  (9)..(9)
<223>  X=SA

<220>
<221>  X
<222>  (10)..(10)
<223>  X=TS

<220>
<221>  X
<222>  (13)..(13)
<223>  X=AV

<220>
<221>  X
<222>  (15)..(15)
<223>  X=VP

<220>
<221>  X
<222>  (17)..(17)
<223>  X=DE

<220>
<221>  X
<222>  (19)..(19)
<223>  X=VA

<220>
<221>  X
<222>  (21)..(21)
<223>  X=IL

<220>
<221>  X
<222>  (22)..(22)
<223>  X=TS

<220>
<221>  X
<222>  (29)..(29)
<223>  X=IV

<220>
<221>  X
<222>  (32)..(32)
<223>  X=W,YH

<220>
<221>  X
<222>  (34)..(34)
<223>  X=AN;

<220>
<221>  X
<222>  (42)..(42)
<223>  X=K,NQ

<220>
<221>  X
<222>  (45)..(45)
<223>  X=KR

<220>
<221>  X
<222>  (50)..(50)
<223>  X=K,R,VG

<220>
<221>  X
<222>  (51)..(51)
<223>  X=AS

<220>
<221>  X
<222>  (53)..(53)
<223>  X=S,T,RI

<220>
<221>  X
<222>  (54)..(54)
<223>  X=LR

<220>
<221>  X
<222>  (55)..(55)
<223>  X=E,D,QA

<220>
<221>  X
<222>  (56)..(56)
<223>  X21=ST

<220>
<221>  X
<222>  (57)..(57)
<223>  X=GD

<220>
<221>  X
<222>  (58)..(58)
<223>  X=VI

<220>
<221>  X
<222>  (60)..(60)
<223>  X=SV

<220>
<221>  X
<222>  (70)..(70)
<223>  X=ED

<220>
<221>  X
<222>  (72)..(72)
<223>  X=TS

<220>
<221>  X
<222>  (75)..(75)
<223>  X=IV

<220>
<221>  X
<222>  (80)..(80)
<223>  X=PS

<220>
<221>  X
<222>  (81)..(81)
<223>  X=DE

<220>
<221>  X
<222>  (85)..(85)
<223>  X=TI

<220>
<221>  X
<222>  (89)..(89)
<223>  X=QR

<220>
<221>  X
<222>  (90)..(90)
<223>  X=Q,LH

<220>
<221>  X
<222>  (91)..(91)
<223>  X=Y-

<220>
<221>  X
<222>  (92)..(92)
<223>  X=N,I,Q-

<220>
<221>  X
<222>  (93)..(93)
<223>  X=S,TN

<220>
<221>  X
<222>  (94)..(94)
<223>  X=Y,W,NQ

<220>
<221>  X
<222>  (95)..(95)
<223>  X=S,T-

<220>
<221>  X
<222>  (96)..(96)
<223>  X=T-

<220>
<221>  X
<222>  (97)..(97)
<223>  X=P-

<220>
<221>  X
<222>  (98)..(98)
<223>  X=Y,RL

<220>
<221>  X
<222>  (102)..(102)
<223>  X=QG

<220>
<221>  X
<222>  (106)..(106)
<223>  X=LV

<400>  153

Xaa Ile Xaa Met Thr Gln Ser Pro Xaa Xaa Leu Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Xaa Thr Xaa Xaa Cys Arg Ala Ser Gln Ser Xaa Ser Ser Xaa 
            20                  25                  30          


Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Xaa Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Xaa Leu Thr Xaa Ser Ser Leu Gln Xaa 
65                  70                  75                  80  


Xaa Asp Phe Ala Xaa Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Thr Phe Gly Xaa Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 


<210>  154
<211>  115
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ɱͨʽ


<220>
<221>  X
<222>  (12)..(12)
<223>  X=VM

<220>
<221>  X
<222>  (13)..(13)
<223>  X=KQ

<220>
<221>  X
<222>  (23)..(23)
<223>  X=TS

<220>
<221>  X
<222>  (27)..(27)
<223>  X=GD

<220>
<221>  X
<222>  (29)..(29)
<223>  X=I,LV

<220>
<221>  X
<222>  (30)..(30)
<223>  X=S,N,DQ

<220>
<221>  X
<222>  (31)..(31)
<223>  X=N,ST

<220>
<221>  X
<222>  (35)..(35)
<223>  X=ST

<220>
<221>  X
<222>  (37)..(37)
<223>  X=IF

<220>
<221>  X
<222>  (40)..(40)
<223>  X=PA

<220>
<221>  X
<222>  (43)..(43)
<223>  X=KR

<220>
<221>  X
<222>  (50)..(50)
<223>  X=YN

<220>
<221>  X
<222>  (56)..(56)
<223>  X=T,NS

<220>
<221>  X
<222>  (58)..(58)
<223>  X=ND

<220>
<221>  X
<222>  (60)..(60)
<223>  X=NQ

<220>
<221>  X
<222>  (61)..(61)
<223>  X=PS

<220>
<221>  X
<222>  (64)..(64)
<223>  X=KT

<220>
<221>  X
<222>  (68)..(68)
<223>  X=TS

<220>
<221>  X
<222>  (69)..(69)
<223>  X=IM

<220>
<221>  X
<222>  (71)..(71)
<223>  X=VI

<220>
<221>  X
<222>  (73)..(73)
<223>  X=TI

<220>
<221>  X
<222>  (81)..(81)
<223>  X=KN

<220>
<221>  X
<222>  (83)..(83)
<223>  X=S,TN

<220>
<221>  X
<222>  (86)..(86)
<223>  X=TI

<220>
<221>  X
<222>  (87)..(87)
<223>  X=AS

<220>
<221>  X
<222>  (88)..(88)
<223>  X=AG

<220>
<221>  X
<222>  (92)..(92)
<223>  X=VM

<220>
<221>  X
<222>  (96)..(96)
<223>  X=AG

<220>
<221>  X
<222>  (98)..(98)
<223>  X=KG

<220>
<221>  X
<222>  (99)..(99)
<223>  X=RK

<220>
<221>  X
<222>  (100)..(100)
<223>  X=G,A,T,WL

<220>
<221>  X
<222>  (101)..(101)
<223>  X=V,M,G,IA

<220>
<221>  X
<222>  (102)..(102)
<223>  X=L,Y,H,F-

<220>
<221>  X
<222>  (103)..(103)
<223>  X=DS

<220>
<221>  X
<222>  (105)..(105)
<223>  X=WS

<220>
<221>  X
<222>  (109)..(109)
<223>  X=TI

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Xaa Xaa Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Xaa Val Ser Gly Xaa Ser Xaa Xaa Xaa Tyr 
            20                  25                  30          


Tyr Trp Xaa Trp Xaa Arg Gln Xaa Pro Gly Xaa Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Ile Tyr Tyr Ser Gly Xaa Thr Xaa Tyr Xaa Xaa Ser Leu Xaa 
    50                  55                  60                  


Ser Arg Val Xaa Xaa Ser Xaa Asp Xaa Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Xaa Leu Xaa Ser Val Xaa Xaa Xaa Asp Thr Ala Xaa Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Gly Gln Gly Xaa Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  155
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR0012641265L-FR3(Combined)

<400>  155

Asp Ile Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  156
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807PR000808L-FR1

<400>  156

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  157
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802-8068111266-1281L-FR1 (Combined)

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  158
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR00079612641265L-FR1

<400>  158

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  159
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR00079612641265L-FR4

<400>  159

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802-8068088111266-1281L-FR4 

<400>  160

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  161
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807L-FR4 (Combined)

<400>  161

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  162
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR00081112801281L-FR3

<400>  162

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  163
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808L-FR3

<400>  163

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  164
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807L-FR3 (Combined)

<400>  164

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Val Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  165
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR001277PR001278PR001279L-FR1

<400>  165

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  166
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000803PR000804PR000806PR001266PR001267PR001
       268PR001269PR001270PR001271PR001272PR001275PR001276
       PR001273PR001274L-FR3

<400>  166

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  167
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807H-FR1

<400>  167

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Met Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  168
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR001277PR001278PR001279H-FR1

<400>  168

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser 
            20                  25  


<210>  169
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR000803PR000804PR000806PR000808PR000811PR001
       266-1276PR001280PR001281H-FR1

<400>  169

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  170
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265H-FR1

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  171
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807H-FR3

<400>  171

Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Gly 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  172
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806H-FR3 

<400>  172

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Ile Asp 
1               5                   10                  15      


Ile Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Ile Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  173
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806 H-FR3

<400>  173

Thr Asn Tyr Asn Ser Ser Leu Thr Ser Arg Val Thr Ile Ser Ile Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  174
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001275 H-FR3

<400>  174

Thr Asn Tyr Gln Ser Ser Leu Thr Ser Arg Val Thr Ile Ser Ile Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  175
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001276 H-FR3

<400>  175

Thr Asn Tyr Asn Pro Ser Leu Thr Ser Arg Val Thr Ile Ser Ile Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  176
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265 H-FR3

<400>  176

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Ile Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ser Ala 
            20                  25                  30          


Asp Thr Ala Met Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  177
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000805PR001266PR001268PR001272PR001277-1279H-FR3

<400>  177

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  178
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR001269PR001267 H-FR3

<400>  178

Thr Asn Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  179
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR001273PR001274 H-FR3

<400>  179

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  180
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808 H-FR3

<400>  180

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Gly Arg 
        35                  40      


<210>  181
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802PR001270-1271H-FR3

<400>  181

Thr Asn Tyr Asn Ser Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Asn Leu Thr Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  182
<211>  41
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811PR001280-1281H-FR3

<400>  182

Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Met Ser Val Asp 
1               5                   10                  15      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            20                  25                  30          


Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
        35                  40      


<210>  183
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000811PR001280-1281H-FR4

<400>  183

Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  184
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000808H-FR2

<400>  184

Tyr Trp Ser Trp Phe Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Asn Ile 
            


<210>  185
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000803PR000804PR000805PR001275PR001276PR001273PR001
       274PR001277PR001278PR001279H-FR4

<400>  185

Trp Gly Gln Gly Ile Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR000802PR000806-808PR0001264-1272H-FR4

<400>  186

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  187
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   PR000806H-FR2

<400>  187

Tyr Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  188
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802-805PR000811PR001266-1281H-FR2

<400>  188

Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  189
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807H-FR2

<400>  189

Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  190
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265H-FR2

<400>  190

Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Ile 
1               5                   10                  15      


Gly Tyr Ile 
            


<210>  191
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000802-805PR000808PR000811PR001266-1281L-FR2

<400>  191

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  192
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000807L-FR2

<400>  192

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  193
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000806L-FR2

<400>  193

Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  194
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  PR000796PR001264PR001265L-FR2

<400>  194

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  195
<211>  327
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  IgG4㶨

<400>  195

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  196
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Igʺ㶨

<400>  196

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  197
<211>  216
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ͨʽ


<220>
<221>  X
<222>  (1)..(1)
<223>  X=DE

<220>
<221>  X
<222>  (3)..(3)
<223>  X=QV

<220>
<221>  X
<222>  (9)..(9)
<223>  X=SA

<220>
<221>  X
<222>  (10)..(10)
<223>  X=TS

<220>
<221>  X
<222>  (13)..(13)
<223>  X=AV

<220>
<221>  X
<222>  (15)..(15)
<223>  X=VP

<220>
<221>  X
<222>  (17)..(17)
<223>  X=DE

<220>
<221>  X
<222>  (19)..(19)
<223>  X=VA

<220>
<221>  X
<222>  (21)..(21)
<223>  X=IL

<220>
<221>  X
<222>  (22)..(22)
<223>  X=TS

<220>
<221>  X
<222>  (29)..(29)
<223>  X=IV

<220>
<221>  X
<222>  (32)..(32)
<223>  X=W,YH

<220>
<221>  X
<222>  (34)..(34)
<223>  X=AN;

<220>
<221>  X
<222>  (42)..(42)
<223>  X=K,NQ

<220>
<221>  X
<222>  (45)..(45)
<223>  X=KR

<220>
<221>  X
<222>  (50)..(50)
<223>  X=K,R,VG

<220>
<221>  X
<222>  (51)..(51)
<223>  X=AS

<220>
<221>  X
<222>  (53)..(53)
<223>  X=S,T,RI

<220>
<221>  X
<222>  (54)..(54)
<223>  X=LR

<220>
<221>  X
<222>  (55)..(55)
<223>  X=E,D,QA

<220>
<221>  X
<222>  (56)..(56)
<223>  X21=ST

<220>
<221>  X
<222>  (57)..(57)
<223>  X=GD

<220>
<221>  X
<222>  (58)..(58)
<223>  X=VI

<220>
<221>  X
<222>  (60)..(60)
<223>  X=SV

<220>
<221>  X
<222>  (70)..(70)
<223>  X=ED

<220>
<221>  X
<222>  (72)..(72)
<223>  X=TS

<220>
<221>  X
<222>  (75)..(75)
<223>  X=IV

<220>
<221>  X
<222>  (80)..(80)
<223>  X=PS

<220>
<221>  X
<222>  (81)..(81)
<223>  X=DE

<220>
<221>  X
<222>  (85)..(85)
<223>  X=TI

<220>
<221>  X
<222>  (89)..(89)
<223>  X=QR

<220>
<221>  X
<222>  (90)..(90)
<223>  X=Q,LH

<220>
<221>  X
<222>  (91)..(91)
<223>  X=Y-

<220>
<221>  X
<222>  (92)..(92)
<223>  X=N,I,Q-

<220>
<221>  X
<222>  (93)..(93)
<223>  X=S,TN

<220>
<221>  X
<222>  (94)..(94)
<223>  X=Y,W,NQ

<220>
<221>  X
<222>  (95)..(95)
<223>  X=S,T-

<220>
<221>  X
<222>  (96)..(96)
<223>  X=T-

<220>
<221>  X
<222>  (97)..(97)
<223>  X=P-

<220>
<221>  X
<222>  (98)..(98)
<223>  X=Y,RL

<220>
<221>  X
<222>  (102)..(102)
<223>  X=QG

<220>
<221>  X
<222>  (106)..(106)
<223>  X=LV

<400>  197

Xaa Ile Xaa Met Thr Gln Ser Pro Xaa Xaa Leu Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Xaa Thr Xaa Xaa Cys Arg Ala Ser Gln Ser Xaa Ser Ser Xaa 
            20                  25                  30          


Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Xaa Leu Leu Ile 
        35                  40                  45              


Tyr Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Xaa Leu Thr Xaa Ser Ser Leu Gln Xaa 
65                  70                  75                  80  


Xaa Asp Phe Ala Xaa Tyr Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Thr Phe Gly Xaa Gly Thr Lys Xaa Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  198
<211>  442
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  ͨʽ


<220>
<221>  X
<222>  (12)..(12)
<223>  X=VM

<220>
<221>  X
<222>  (13)..(13)
<223>  X=KQ

<220>
<221>  X
<222>  (23)..(23)
<223>  X=TS

<220>
<221>  X
<222>  (27)..(27)
<223>  X=GD

<220>
<221>  X
<222>  (29)..(29)
<223>  X=I,LV

<220>
<221>  X
<222>  (30)..(30)
<223>  X=S,N,DQ

<220>
<221>  X
<222>  (31)..(31)
<223>  X=N,ST

<220>
<221>  X
<222>  (35)..(35)
<223>  X=ST

<220>
<221>  X
<222>  (37)..(37)
<223>  X=IF

<220>
<221>  X
<222>  (40)..(40)
<223>  X=PA

<220>
<221>  X
<222>  (43)..(43)
<223>  X=KR

<220>
<221>  X
<222>  (50)..(50)
<223>  X=YN

<220>
<221>  X
<222>  (56)..(56)
<223>  X=T,NS

<220>
<221>  X
<222>  (58)..(58)
<223>  X=ND

<220>
<221>  X
<222>  (60)..(60)
<223>  X=NQ

<220>
<221>  X
<222>  (61)..(61)
<223>  X=PS

<220>
<221>  X
<222>  (64)..(64)
<223>  X=KT

<220>
<221>  X
<222>  (68)..(68)
<223>  X=TS

<220>
<221>  X
<222>  (69)..(69)
<223>  X=IM

<220>
<221>  X
<222>  (71)..(71)
<223>  X=VI

<220>
<221>  X
<222>  (73)..(73)
<223>  X=TI

<220>
<221>  X
<222>  (81)..(81)
<223>  X=KN

<220>
<221>  X
<222>  (83)..(83)
<223>  X=S,TN

<220>
<221>  X
<222>  (86)..(86)
<223>  X=TI

<220>
<221>  X
<222>  (87)..(87)
<223>  X=AS

<220>
<221>  X
<222>  (88)..(88)
<223>  X=AG

<220>
<221>  X
<222>  (92)..(92)
<223>  X=VM

<220>
<221>  X
<222>  (96)..(96)
<223>  X=AG

<220>
<221>  X
<222>  (98)..(98)
<223>  X=KG

<220>
<221>  X
<222>  (99)..(99)
<223>  X=RK

<220>
<221>  X
<222>  (100)..(100)
<223>  X=G,A,T,WL

<220>
<221>  X
<222>  (101)..(101)
<223>  X=V,M,G,IA

<220>
<221>  X
<222>  (102)..(102)
<223>  X=L,Y,H,F-

<220>
<221>  X
<222>  (103)..(103)
<223>  X=DS

<220>
<221>  X
<222>  (105)..(105)
<223>  X=WS

<220>
<221>  X
<222>  (109)..(109)
<223>  X=TI

<400>  198

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Xaa Xaa Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Xaa Val Ser Gly Xaa Ser Xaa Xaa Xaa Tyr 
            20                  25                  30          


Tyr Trp Xaa Trp Xaa Arg Gln Xaa Pro Gly Xaa Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Xaa Ile Tyr Tyr Ser Gly Xaa Thr Xaa Tyr Xaa Xaa Ser Leu Xaa 
    50                  55                  60                  


Ser Arg Val Xaa Xaa Ser Xaa Asp Xaa Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Xaa Leu Xaa Ser Val Xaa Xaa Xaa Asp Thr Ala Xaa Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Gly Gln Gly Xaa Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440         


