                         SEQUENCE LISTING

<110>  THE ROCKEFELLER UNIVERSITY
 
<120>  CRISPR GENOME EDITING WITH CELL SURFACE DISPLAY TO PRODUCE 
       HOMOZYGOUSLY EDITED EUKARYOTIC CELLS

<130>  076091.00094

<150>  62/887,172
<151>  2019-08-15

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  llinker

<400>  1

Ser Gly Ser Gly 
1               


<210>  2
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  2

Gly Ala Ser Gly Ser Gly 
1               5       


<210>  3
<211>  38
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  3

Gly Gly Thr Gly Ser Gly Gly Ser Ala Gly Gly Thr Gly Gly Ser Ala 
1               5                   10                  15      


Gly Gly Ser Ala Gly Ala Gly Gly Ala Thr Gly Gly Ser Thr Ala Gly 
            20                  25                  30          


Gly Ala Thr Thr Ala Ser 
        35              


<210>  4
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  4

Ser Asn Ser Ala Asp Gly Asp Gly Ser Asn Ala Thr Gly Ser Ser Ala 
1               5                   10                  15      


Gly Ala Gly Ser Gly Thr Ser Gly Gly Asp Asn Thr Ser Asp Gly Ser 
            20                  25                  30          


Gly Ala Ser Ala Gly Ala Ala Ser Thr Asn Ser Asn Gly Asn Thr Gly 
        35                  40                  45              


Ser Ala Thr Ser Gly Gly Ala Thr Gly Ser Asp Thr Ser Gly Ala Thr 
    50                  55                  60                  


Ala Gly Ser Gly Ala Ser Asp Gly Gly Asn Gly Ala Thr Ala Ser Ser 
65                  70                  75                  80  


Thr Thr Gly Asn Gly Asn Ser Ser Gly Thr Thr Ala Thr Thr Gly Gly 
                85                  90                  95      


Gly Asp Ala Gly 
            100 


<210>  5
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  5

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  6
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  ribosomal skipping sequence

<400>  6

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  7
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  ribosomal skipping sequence

<400>  7

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  8
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  ribosomal skipping sequence

<400>  8

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  10
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala 
            20                  25      


<210>  11
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  11

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp 
            20      


<210>  12
<211>  3561
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  12
ccggcgaggt tcccaggtgg gaccccagga tggtcttgat cccctgacct tgtgatctgc       60

ccacctcggc ctcccaaagt gctgggatta caggcatgag ccaccacgcc cagccatagt      120

catcattttt aatagctttg tataatttgc ttttctaatc cctttattgg taggaaatta      180

gagttgtttc cgactttggc ccttaaattg ggttatgtgt aggactgctt tggaaactaa      240

tgttactagg gaaatggtgt tgtaaagttc tagcttctgc gggttgtaag ttacctttca      300

atggagggat gggtgggcag agggagcttt gaccttctct ggacatacat tagaggaaaa      360

atggaaggga ggcctgtttc cagggggata attgtgccaa agtggaatgt ccaggtcagg      420

acatgagccg tgtggaagct ggaaccacgt gaggtctgcc tagttcatgt gctggccacc      480

acctggaggc ccccttctca tccctgctgg cgctgggggt gagccatcat ttggcaacag      540

gagggggcct cctattctca gccagatgtg acccttccgt tccttggccc tgcaggaaga      600

agatgaagct gcagggacag ttcaaaggcc tggtgaaggc tgctcggcga ggttcccagg      660

tgggacacaa aaatcgccgg aaagatagaa gacccgcggc cgccgggggc acgggaagtg      720

gtggatcagc cggtggcact ggtggctctg ccggagggtc agcgggagca gggggagcca      780

caggcggatc tacggctgga ggggcgacaa cggcctctgc gatcgctggc gaaaatctgt      840

attttcaggg aggagctagc ggaagcggaa tggtcagtaa gggtgaggag gacaacatgg      900

ctataatcaa agagtttatg cggtttaagg tccatatgga aggttcagtt aatggacatg      960

agttcgagat agaaggtgag ggtgaggggc gaccgtacga aggcacacaa accgcaaagt     1020

tgaaagtcac caaaggtgga cccttgccct ttgcttggga tattctctcc cctcaattca     1080

tgtacggcag taaggcatac gtcaaacatc ccgctgacat ccccgactat ctgaagctgt     1140

ctttccctga gggttttaaa tgggagcgag tgatgaactt cgaggacggg ggagtggtaa     1200

cagtgactca agattcctct ttgcaggacg gggagttcat atataaagtg aaactgcggg     1260

gtacgaactt tccaagtgac ggtcccgtaa tgcagaagaa gacgatggga tgggaggcaa     1320

gcagcgagcg aatgtatcct gaggatggag cccttaaggg agaaattaag caacggctga     1380

agttgaaaga tggtggacat tatgatgctg aggttaaaac aacttataaa gccaagaaac     1440

cagttcagtt gccaggggcg tataacgtca acattaaact ggacattaca tctcacaatg     1500

aagattacac aatcgttgag caatatgaac gcgcggaggg tcggcactca acgggtggca     1560

tggacgagtt gtataaaggc gcgcccggaa gcggagctac taacttcagc ctgctgaagc     1620

aggctggaga cgtggaggag aaccctggac ctatgggctg gtcatgtatc attctgtttc     1680

tggtcgcaac cgcaactgga gtgcattcac aggtgcagct cggcggaccg acgaatcctg     1740

aaaaggtgaa ggtctggtac gagaggtccc ttgttctgca aaaggaggca gactcacttt     1800

gtactttcat agatgatttg aagctggcga tagcacgaga gagtgatggt aaagacgcga     1860

aagtgaacga catacgacgc aaagataacc ttgacgcttc aagtgtcgtg atgctgaacc     1920

caatcaacgg aaaaggctca acccttcgga aggaagtgga taagtttcgg gagcttgtag     1980

ctacgttgat gacggacaag gccaagctca agttgattga acaggcactg aatactgaaa     2040

gcggaacgaa gggtaagagc tgggagtcct cactgttcga gaatatgcca acagttgccg     2100

cgattacgct cctgacgaag ctccagtcag acgtacggta cgcgcaaggt gaggtacttg     2160

ctgatcttgt aaaagggagc ggaactaccg gtttggaagt gcttttccag gggcctgccg     2220

cggcctctaa ttccgctgac ggtgacggtt caaatgctac agggagttct gctggtgctg     2280

gctctggaac gagtggcggg gacaacacga gtgatggctc cggggcgagt gccggtgcag     2340

ccagcacaaa ttcaaatggg aacacgggta gtgcgacttc tgggggggcc acaggtagcg     2400

atacgtcagg agcgacggct ggtagtgggg cttccgacgg cggaaacggc gcaacagcgt     2460

catcaactac aggcaacgga aattcaagcg gtacaaccgc gacgaccgga ggcggtgatg     2520

caggggggtc gactaatgct gtgggccagg acacgcagga ggtcatcgtg gtgccacact     2580

ccttgccctt taaggtggtg gtgatctcag ccatcctggc cctggtggtg ctcaccatca     2640

tctcccttat catcctcatc atgctttggc agaagaagcc acgttaggcg cgcaataatg     2700

ccggctactt gctttaaaaa acctcccaca cctccccctg aacctgaaac ataaaatgaa     2760

tgcaattgtt gttgttaact tgtttattgc agcttataat ggttacaaat aaagcaatag     2820

catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg gtttgtccaa     2880

actcatcaat gtatcttaac gcgtttcgaa ttaattaaag gttcccaggt gggacacaaa     2940

aaccgcagaa aggatcgtcg accctgaggc ccagggcccc tgggctgccc tgtggtccag     3000

tctgaggccc tttcagcccc caggctgcct tgccaccagc tccaggtgct caagattctg     3060

gcagagcctg gactcaggat gacttggaac tagggcttgg ctctcagaag tcctggattt     3120

tggaaactcc aaatggaatc acccttcaga gacatccctg gtgcctggag atgggaatgt     3180

ggcctcagtg cctctgagta ggtgccatga ggcacctttg ctttctgccc agagtggcca     3240

tgagcaccag aacagatgat ctccatttcc gccagctgcc tgtagccacg tggcatcctg     3300

cctgtggtct gggtgagatt tactgtgacc agatgtagaa taaatgtgtc tcatcctgca     3360

ttttttttct agaaactgtt tcatagtctg ccccctccag gggtaagaac agtgtgcagt     3420

tgttggcagc agtggcctga cctcttcctg tctaactcct tacatccagt ccagggcata     3480

tcataaggct ttgcccatag gacaggcttt ggaacttgcc cgggagcacc cacctgtgcc     3540

ggcgaggttc ccaggtggga c                                               3561


<210>  13
<211>  3396
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  13
ccggcgaggt tcccaggtgg gaccccagga tggtcttgat cccctgacct tgtgatctgc       60

ccacctcggc ctcccaaagt gctgggatta caggcatgag ccaccacgcc cagccatagt      120

catcattttt aatagctttg tataatttgc ttttctaatc cctttattgg taggaaatta      180

gagttgtttc cgactttggc ccttaaattg ggttatgtgt aggactgctt tggaaactaa      240

tgttactagg gaaatggtgt tgtaaagttc tagcttctgc gggttgtaag ttacctttca      300

atggagggat gggtgggcag agggagcttt gaccttctct ggacatacat tagaggaaaa      360

atggaaggga ggcctgtttc cagggggata attgtgccaa agtggaatgt ccaggtcagg      420

acatgagccg tgtggaagct ggaaccacgt gaggtctgcc tagttcatgt gctggccacc      480

acctggaggc ccccttctca tccctgctgg cgctgggggt gagccatcat ttggcaacag      540

gagggggcct cctattctca gccagatgtg acccttccgt tccttggccc tgcaggaaga      600

agatgaagct gcagggacag ttcaaaggcc tggtgaaggc tgctcggcga ggttcccagg      660

tgggacacaa aaatcgccgg aaagatagaa gacccgcggc cgccgggggc acgggaagtg      720

gtggatcagc cggtggcact ggtggctctg ccggagggtc agcgggagca gggggagcca      780

caggcggatc tacggctgga ggggcgacaa cggcctctgc gatcgctggc gaaaatctgt      840

attttcaggg aggagctagc ggaagcggaa tggtcagtaa gggtgaggag gacaacatgg      900

ctataatcaa agagtttatg cggtttaagg tccatatgga aggttcagtt aatggacatg      960

agttcgagat agaaggtgag ggtgaggggc gaccgtacga aggcacacaa accgcaaagt     1020

tgaaagtcac caaaggtgga cccttgccct ttgcttggga tattctctcc cctcaattca     1080

tgtacggcag taaggcatac gtcaaacatc ccgctgacat ccccgactat ctgaagctgt     1140

ctttccctga gggttttaaa tgggagcgag tgatgaactt cgaggacggg ggagtggtaa     1200

cagtgactca agattcctct ttgcaggacg gggagttcat atataaagtg aaactgcggg     1260

gtacgaactt tccaagtgac ggtcccgtaa tgcagaagaa gacgatggga tgggaggcaa     1320

gcagcgagcg aatgtatcct gaggatggag cccttaaggg agaaattaag caacggctga     1380

agttgaaaga tggtggacat tatgatgctg aggttaaaac aacttataaa gccaagaaac     1440

cagttcagtt gccaggggcg tataacgtca acattaaact ggacattaca tctcacaatg     1500

aagattacac aatcgttgag caatatgaac gcgcggaggg tcggcactca acgggtggca     1560

tggacgagtt gtataaaggc gcgcccggaa gcggagctac taacttcagc ctgctgaagc     1620

aggctggaga cgtggaggag aaccctggac ctatgggctg gtcatgtatc attctgtttc     1680

tggtcgcaac cgcaactgga gtgcattcac aggtgcagct cggcggaccg tcccaactga     1740

gccaagtaac gccagtggat gaagtggacg gaaccagaac gtatcgcgtt cgggggcaac     1800

tctttttcgt ctctacccat gacttcttgc accagttcga ctttacccat ccagcaaggc     1860

gggtggtgat tgacctctct gacgctcact tttgggatgg gagtgccgta ggagctttgg     1920

acaaggtgat gctgaagttt atgagacagg gcacgagtgt cgagctgcgc gggctgaacg     1980

ctgcaagtgc cactcttgtt gaacggcttg ggagcggaac taccggtggc gaaaatctgt     2040

attttcaggg agccgcggcc tctaattccg ctgacggtga cggttcaaat gctacaggga     2100

gttctgctgg tgctggctct ggaacgagtg gcggggacaa cacgagtgat ggctccgggg     2160

cgagtgccgg tgcagccagc acaaattcaa atgggaacac gggtagtgcg acttctgggg     2220

gggccacagg tagcgatacg tcaggagcga cggctggtag tggggcttcc gacggcggaa     2280

acggcgcaac agcgtcatca actacaggca acggaaattc aagcggtaca accgcgacga     2340

ccggaggcgg tgatgcaggg gggtcgacta atgctgtggg ccaggacacg caggaggtca     2400

tcgtggtgcc acactccttg ccctttaagg tggtggtgat ctcagccatc ctggccctgg     2460

tggtgctcac catcatctcc cttatcatcc tcatcatgct ttggcagaag aagccacgtt     2520

aggcgcgcaa taatgccggc tacttgcttt aaaaaacctc ccacacctcc ccctgaacct     2580

gaaacataaa atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta     2640

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag     2700

ttgtggtttg tccaaactca tcaatgtatc ttaacgcgtt tcgaattaat taaaggttcc     2760

caggtgggac acaaaaaccg cagaaaggat cgtcgaccct gaggcccagg gcccctgggc     2820

tgccctgtgg tccagtctga ggccctttca gcccccaggc tgccttgcca ccagctccag     2880

gtgctcaaga ttctggcaga gcctggactc aggatgactt ggaactaggg cttggctctc     2940

agaagtcctg gattttggaa actccaaatg gaatcaccct tcagagacat ccctggtgcc     3000

tggagatggg aatgtggcct cagtgcctct gagtaggtgc catgaggcac ctttgctttc     3060

tgcccagagt ggccatgagc accagaacag atgatctcca tttccgccag ctgcctgtag     3120

ccacgtggca tcctgcctgt ggtctgggtg agatttactg tgaccagatg tagaataaat     3180

gtgtctcatc ctgcattttt tttctagaaa ctgtttcata gtctgccccc tccaggggta     3240

agaacagtgt gcagttgttg gcagcagtgg cctgacctct tcctgtctaa ctccttacat     3300

ccagtccagg gcatatcata aggctttgcc cataggacag gctttggaac ttgcccggga     3360

gcacccacct gtgccggcga ggttcccagg tgggac                               3396


<210>  14
<211>  3571
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  14
cccacgatga ggcggtgagg tctgaccagc gttggcaaca tattgagacc ctgtctctac       60

cccccaaaaa aaaaaagaaa gggctacgca tggtggtgca cacctgtagt caatcccagc      120

tactccggag gctgaagtgg gaggatcgtt tgaggctgca gtgagctatg attgtgccac      180

tgtgctccag gctgagcaac agagaaagac cctgtccctt taaaaaaatt aaaaatatat      240

tgtcagatga ccccggaaag aaggttcttc ctgttgtacc cctttccacc agctcctggt      300

gaaggttcta gtggcatcca gctttcccag gtggtgtagg gaaatggggc agttgccaag      360

gctccttcca gctctgggag tttaggattc tcttatctcg agatttgtgg gcccatgaaa      420

taatgttgtt aaagcagggc tagcgcatgt tttctcacca tgaagtgggt caggtagatt      480

tttttcctgt gagaatttgt gaccttttct tgaagctctg cttttaaggg atatagcttt      540

gagttctgtg ccccccaccc tcccttctac acatacctca gcctgacctt cgccttcccc      600

ctcacaggcc aacaagctgg cggagaagcg gaaagcacac gatgaggctg taagatcaga      660

gaagaaggcg aaaaaggcgc gacctgaggc ggccgccggg ggcacgggaa gtggtggatc      720

agccggtggc actggtggct ctgccggagg gtcagcggga gcagggggag ccacaggcgg      780

atctacggct ggaggggcga caacggcctc tgcgatcgct ggcgaaaatc tgtattttca      840

gggaggagct agcggaagcg gaatggtcag taagggtgag gaggacaaca tggctataat      900

caaagagttt atgcggttta aggtccatat ggaaggttca gttaatggac atgagttcga      960

gatagaaggt gagggtgagg ggcgaccgta cgaaggcaca caaaccgcaa agttgaaagt     1020

caccaaaggt ggacccttgc cctttgcttg ggatattctc tcccctcaat tcatgtacgg     1080

cagtaaggca tacgtcaaac atcccgctga catccccgac tatctgaagc tgtctttccc     1140

tgagggtttt aaatgggagc gagtgatgaa cttcgaggac gggggagtgg taacagtgac     1200

tcaagattcc tctttgcagg acggggagtt catatataaa gtgaaactgc ggggtacgaa     1260

ctttccaagt gacggtcccg taatgcagaa gaagacgatg ggatgggagg caagcagcga     1320

gcgaatgtat cctgaggatg gagcccttaa gggagaaatt aagcaacggc tgaagttgaa     1380

agatggtgga cattatgatg ctgaggttaa aacaacttat aaagccaaga aaccagttca     1440

gttgccaggg gcgtataacg tcaacattaa actggacatt acatctcaca atgaagatta     1500

cacaatcgtt gagcaatatg aacgcgcgga gggtcggcac tcaacgggtg gcatggacga     1560

gttgtataaa ggcgcgcccg gaagcggagc tactaacttc agcctgctga agcaggctgg     1620

agacgtggag gagaaccctg gacctatggg ctggtcatgt atcattctgt ttctggtcgc     1680

aaccgcaact ggagtgcatt cacaggtgca gctcggcgga ccgacgaatc ctgaaaaggt     1740

gaaggtctgg tacgagaggt cccttgttct gcaaaaggag gcagactcac tttgtacttt     1800

catagatgat ttgaagctgg cgatagcacg agagagtgat ggtaaagacg cgaaagtgaa     1860

cgacatacga cgcaaagata accttgacgc ttcaagtgtc gtgatgctga acccaatcaa     1920

cggaaaaggc tcaacccttc ggaaggaagt ggataagttt cgggagcttg tagctacgtt     1980

gatgacggac aaggccaagc tcaagttgat tgaacaggca ctgaatactg aaagcggaac     2040

gaagggtaag agctgggagt cctcactgtt cgagaatatg ccaacagttg ccgcgattac     2100

gctcctgacg aagctccagt cagacgtacg gtacgcgcaa ggtgaggtac ttgctgatct     2160

tgtaaaaggg agcggaacta ccggtttgga agtgcttttc caggggcctg ccgcggcctc     2220

taattccgct gacggtgacg gttcaaatgc tacagggagt tctgctggtg ctggctctgg     2280

aacgagtggc ggggacaaca cgagtgatgg ctccggggcg agtgccggtg cagccagcac     2340

aaattcaaat gggaacacgg gtagtgcgac ttctgggggg gccacaggta gcgatacgtc     2400

aggagcgacg gctggtagtg gggcttccga cggcggaaac ggcgcaacag cgtcatcaac     2460

tacaggcaac ggaaattcaa gcggtacaac cgcgacgacc ggaggcggtg atgcaggggg     2520

gtcgactaat gctgtgggcc aggacacgca ggaggtcatc gtggtgccac actccttgcc     2580

ctttaaggtg gtggtgatct cagccatcct ggccctggtg gtgctcacca tcatctccct     2640

tatcatcctc atcatgcttt ggcagaagaa gccacgttag gcgcgcaata atgccggcta     2700

cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt     2760

gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca     2820

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc     2880

aatgtatctt aacgcgtttc gaattaatta aatgaggcgg tgaggtctga gaagaaggcc     2940

aagaaggcaa ggccggagtg agtgcctgcg gcccctcaca gggctgaggc cagcccctag     3000

cagctggatg tggcagaggc aggccagagg acctaagtgt gatggaccag agtcacttct     3060

cctcctcctt tctccagcca gccctgaccc ctcatgctct ctggctgggc cagtgggcag     3120

ccctcgcttc ccttggatgg agctgccctg ctggtgcctg gtcagagaag aggcctctgt     3180

gcccagcctg attctctgct cccaggagcc agtgacatga ggtgcagagg cccacccagc     3240

cccctaccta ctgcccccat tcatcctggc tttccacagc cccctcccac acagttggac     3300

ccgtgattct cagggtgctg tgatggggtg agggtagggg gagcatttgt tattaaatga     3360

ctggactttt gtgccaattg cattttgtgt ccatgagcct tcctagggtt ggaggaggcc     3420

tacctagcac tctatgctgc aggctgggcc agccctgggt atttactgag acagagctgg     3480

gcactgctca gagctctctg gatgtccaag gacccctcca ggtccaggga tgccaaaagg     3540

taggtgcacc cacgatgagg cggtgaggtc t                                    3571


<210>  15
<211>  3406
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  15
cccacgatga ggcggtgagg tctgaccagc gttggcaaca tattgagacc ctgtctctac       60

cccccaaaaa aaaaaagaaa gggctacgca tggtggtgca cacctgtagt caatcccagc      120

tactccggag gctgaagtgg gaggatcgtt tgaggctgca gtgagctatg attgtgccac      180

tgtgctccag gctgagcaac agagaaagac cctgtccctt taaaaaaatt aaaaatatat      240

tgtcagatga ccccggaaag aaggttcttc ctgttgtacc cctttccacc agctcctggt      300

gaaggttcta gtggcatcca gctttcccag gtggtgtagg gaaatggggc agttgccaag      360

gctccttcca gctctgggag tttaggattc tcttatctcg agatttgtgg gcccatgaaa      420

taatgttgtt aaagcagggc tagcgcatgt tttctcacca tgaagtgggt caggtagatt      480

tttttcctgt gagaatttgt gaccttttct tgaagctctg cttttaaggg atatagcttt      540

gagttctgtg ccccccaccc tcccttctac acatacctca gcctgacctt cgccttcccc      600

ctcacaggcc aacaagctgg cggagaagcg gaaagcacac gatgaggctg taagatcaga      660

gaagaaggcg aaaaaggcgc gacctgaggc ggccgccggg ggcacgggaa gtggtggatc      720

agccggtggc actggtggct ctgccggagg gtcagcggga gcagggggag ccacaggcgg      780

atctacggct ggaggggcga caacggcctc tgcgatcgct ggcgaaaatc tgtattttca      840

gggaggagct agcggaagcg gaatggtcag taagggtgag gaggacaaca tggctataat      900

caaagagttt atgcggttta aggtccatat ggaaggttca gttaatggac atgagttcga      960

gatagaaggt gagggtgagg ggcgaccgta cgaaggcaca caaaccgcaa agttgaaagt     1020

caccaaaggt ggacccttgc cctttgcttg ggatattctc tcccctcaat tcatgtacgg     1080

cagtaaggca tacgtcaaac atcccgctga catccccgac tatctgaagc tgtctttccc     1140

tgagggtttt aaatgggagc gagtgatgaa cttcgaggac gggggagtgg taacagtgac     1200

tcaagattcc tctttgcagg acggggagtt catatataaa gtgaaactgc ggggtacgaa     1260

ctttccaagt gacggtcccg taatgcagaa gaagacgatg ggatgggagg caagcagcga     1320

gcgaatgtat cctgaggatg gagcccttaa gggagaaatt aagcaacggc tgaagttgaa     1380

agatggtgga cattatgatg ctgaggttaa aacaacttat aaagccaaga aaccagttca     1440

gttgccaggg gcgtataacg tcaacattaa actggacatt acatctcaca atgaagatta     1500

cacaatcgtt gagcaatatg aacgcgcgga gggtcggcac tcaacgggtg gcatggacga     1560

gttgtataaa ggcgcgcccg gaagcggagc tactaacttc agcctgctga agcaggctgg     1620

agacgtggag gagaaccctg gacctatggg ctggtcatgt atcattctgt ttctggtcgc     1680

aaccgcaact ggagtgcatt cacaggtgca gctcggcgga ccgtcccaac tgagccaagt     1740

aacgccagtg gatgaagtgg acggaaccag aacgtatcgc gttcgggggc aactcttttt     1800

cgtctctacc catgacttct tgcaccagtt cgactttacc catccagcaa ggcgggtggt     1860

gattgacctc tctgacgctc acttttggga tgggagtgcc gtaggagctt tggacaaggt     1920

gatgctgaag tttatgagac agggcacgag tgtcgagctg cgcgggctga acgctgcaag     1980

tgccactctt gttgaacggc ttgggagcgg aactaccggt ggcgaaaatc tgtattttca     2040

gggagccgcg gcctctaatt ccgctgacgg tgacggttca aatgctacag ggagttctgc     2100

tggtgctggc tctggaacga gtggcgggga caacacgagt gatggctccg gggcgagtgc     2160

cggtgcagcc agcacaaatt caaatgggaa cacgggtagt gcgacttctg ggggggccac     2220

aggtagcgat acgtcaggag cgacggctgg tagtggggct tccgacggcg gaaacggcgc     2280

aacagcgtca tcaactacag gcaacggaaa ttcaagcggt acaaccgcga cgaccggagg     2340

cggtgatgca ggggggtcga ctaatgctgt gggccaggac acgcaggagg tcatcgtggt     2400

gccacactcc ttgcccttta aggtggtggt gatctcagcc atcctggccc tggtggtgct     2460

caccatcatc tcccttatca tcctcatcat gctttggcag aagaagccac gttaggcgcg     2520

caataatgcc ggctacttgc tttaaaaaac ctcccacacc tccccctgaa cctgaaacat     2580

aaaatgaatg caattgttgt tgttaacttg tttattgcag cttataatgg ttacaaataa     2640

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt     2700

ttgtccaaac tcatcaatgt atcttaacgc gtttcgaatt aattaaatga ggcggtgagg     2760

tctgagaaga aggccaagaa ggcaaggccg gagtgagtgc ctgcggcccc tcacagggct     2820

gaggccagcc cctagcagct ggatgtggca gaggcaggcc agaggaccta agtgtgatgg     2880

accagagtca cttctcctcc tcctttctcc agccagccct gacccctcat gctctctggc     2940

tgggccagtg ggcagccctc gcttcccttg gatggagctg ccctgctggt gcctggtcag     3000

agaagaggcc tctgtgccca gcctgattct ctgctcccag gagccagtga catgaggtgc     3060

agaggcccac ccagccccct acctactgcc cccattcatc ctggctttcc acagccccct     3120

cccacacagt tggacccgtg attctcaggg tgctgtgatg gggtgagggt agggggagca     3180

tttgttatta aatgactgga cttttgtgcc aattgcattt tgtgtccatg agccttccta     3240

gggttggagg aggcctacct agcactctat gctgcaggct gggccagccc tgggtattta     3300

ctgagacaga gctgggcact gctcagagct ctctggatgt ccaaggaccc ctccaggtcc     3360

agggatgcca aaaggtaggt gcacccacga tgaggcggtg aggtct                    3406


<210>  16
<211>  4008
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  16
agttgctact gaatcgcctc tggtggattg gttggttagt ttcaaatctt ataccttaat       60

atatgggtta agaatgaatc attctctgag tataatctaa ttatttttga gttacacaga      120

tgtggtggta tctttacatt ttttgtgttt gtgatttaga tctgctactg aactttttga      180

ggcatatagc atggcagaaa tgacattcaa tcctcctgtt gaatcttcaa accccaaaat      240

aaaggtatgg gatatttttc atttttttaa aggaagaaat agaaaccaat gtatctcaat      300

aactctaact ccagtttgct taattatttt ataggtagtt ttttttttaa tgtttaggat      360

ttcatcatag gatggatttc tgaggttgaa attctataga gatgatcatg aaactgttcg      420

ttcaatatag gatatgtcca agaccttacc aagcatctgt cattgtgttg catgtgttgg      480

tgtcagctgt tgccattttc aacttggttc acaggttggc tttagcttat agcataagta      540

acttctaact catactttaa atattttcct agggtaaatt tttacaaggg gattcatttt      600

tgaatgaaga tttaaatcag ctaatcaaaa gatactccag tgaagttgct actgaatcgc      660

ctcttgactt taccaagtac ctcaagacaa gtcttcacgc ggccgccggg ggcacgggaa      720

gtggtggatc agccggtggc actggtggct ctgccggagg gtcagcggga gcagggggag      780

ccacaggcgg atctacggct ggaggggcga caacggcctc tgcgatcgct ttggaagtgc      840

ttttccaggg gcctggagct agcggaagcg gaggatcaaa gggagaggaa ctctttaccg      900

gcgtcgttcc aatccttgtt gaactggatg gggacgtgaa tgggcataaa ttttcagtat      960

caggggaagg ggaaggcgac gctacatatg gaaaattgac tctcaaattc atatgcacta     1020

ctggtaaatt gcccgtgcct tggcctacac tcgtcacgac cttcgggtat ggtgttcaat     1080

gtttcgccag gtatccggat catatgaaac aacacgattt cttcaaatca gcgatgccgg     1140

aagggtatgt gcaggagcga acaatctttt tcaaggacga cggcaactat aaaacacggg     1200

ccgaagtcaa atttgaggga gatacgctcg ttaatcggat agagctgaag ggcatcgact     1260

ttaaggagga tgggaacatc ttgggccata agctggaata taattataac agccacaacg     1320

tttacattat ggccgacaaa cagaagaatg gtattaaggt gaattttaaa ataaggcaca     1380

acatagaaga cggatctgtg caactggccg accactatca gcagaatacg cctattggcg     1440

atggtccagt gcttctccct gacaaccatt acctcagtac gcaaagtgct ctctctaaag     1500

accccaacga aaaacgcgat cacatggtac tgctggagtt cgtaaccgcc gcaggaataa     1560

ctcatggaat ggatgaactc tacaaggttg acttggataa aggcgcgccc ggaagttcct     1620

attctctaga aagtatagga acttcggggt ctggcgaagg cagaggctcc cttttgacat     1680

gcggagacgt cgaggagaac ccgggtccca tggagacaga cacactcctg ctatgggtac     1740

tgctcctctg ggttccaggt tccactggcg acggcggacc gaccgccaac acctcctcca     1800

cctccaccaa cggcaacgct gcgccacggg ttattaccct ttcacctgcg aacacagaat     1860

tggccttcgc agcggggatc acgccggttg gcgttagtag ctattcagat tatccgccac     1920

aggcacaaaa aatcgagcaa gtctcaactt ggcagggtat gaacctggaa cgcatagtgg     1980

ctttgaagcc cgacctggtt atcgcttggc ggggcgggaa tgccgagagg caggttgatc     2040

agttggcctc cctgggtata aaagtaatgt gggtggatgc aacaagtatt gaacaaatag     2100

caaatgcctt gagacagttg gccccgtgga gtccccagcc tgacaaagct gaacaagctg     2160

ctcaaagcct tcttgaccag tatgcacagt tgaaagcgca atacgcagat aagcctaaga     2220

agcgcgtatt tttgcaattt ggaattaatc ctccatttac ctctggtaag gagtcaattc     2280

aaaatcaagt cttggaggtc tgtggagggg agaatatttt taaggatagt agggtcccct     2340

ggccccaggt aagccgagaa caagtgctgg cccggagtcc acaggcaatc gtcatcacag     2400

ggggacccga ccaaattccc aagatcaaac agtactgggg ggagcaactc aaaattccag     2460

tcataccact gacatcagac tggttcgaac gggcaagccc ccggatcata ctcgctgcac     2520

aacaactctg caatgcgttg agccaggttg acggaggaaa ctcctccaac tccgccacca     2580

acacctccgc caccaccggt ttggaagtgc ttttccaggg gcctgccgcg gcctctaatt     2640

ccgctgacgg tgacggttca aatgctacag ggagttctgc tggtgctggc tctggaacga     2700

gtggcgggga caacacgagt gatggctccg gggcgagtgc cggtgcagcc agcacaaatt     2760

caaatgggaa cacgggtagt gcgacttctg ggggggccac aggtagcgat acgtcaggag     2820

cgacggctgg tagtggggct tccgacggcg gaaacggcgc aacagcgtca tcaactacag     2880

gcaacggaaa ttcaagcggt acaaccgcga cgaccggagg cggtgatgca ggggggtcga     2940

ctaatgctgt gggccaggac acgcaggagg tcatcgtggt gccacactcc ttgcccttta     3000

aggtggtggt gatctcagcc atcctggccc tggtggtgct caccatcatc tcccttatca     3060

tcctcatcat gctttggcag aagaagccac gttaggcgcg caataatgga agttcctatt     3120

ctctagaaag tataggaact tcgtaagccg gctacttgct ttaaaaaacc tcccacacct     3180

ccccctgaac ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc     3240

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3300

actgcattct agttgtggtt tgtccaaact catcaatgta tcttaacgcg tttcgaatta     3360

attaactctg gatttcacga aatatttgaa aacatcacta cactagtaga ggaatgaagt     3420

cagtggactt tcttgtatat ttgtgtgtgc agatgtacat aaagatgagt tgttaactta     3480

ggatcttttc tttttataca aggaaagctt cctaagaatg tctaggaaga agaggaagaa     3540

tgaccctttg catggcacag ggttctgccc ctattctgaa tatgtcattc catcaaggag     3600

atcaaaagcc tttttttctc cccagtattt ggaaattact ttcttgatga tgctgccttt     3660

taaaagcttc acgtacatta tagtttttta aaaaaatctt tggactggat cttactgaag     3720

tgcagttgct atattaaaat tagggcatag agcacagaaa aatcaagacc atgagaagac     3780

attttaccat ttagctactt tttataacta aatactcttt aaatattttt atttcaatac     3840

tgtggatgga aatgagaagc attctaaatt tgagttaata tatttttatg aagatatttg     3900

agaaaagaaa aaaatagctt gtattcaggt tcattggctt ttgctggatg atccacctaa     3960

agaagttacc taatttggcc ttttaagttg ctactgaatc gcctctgg                  4008


<210>  17
<211>  3738
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  17
agttgctact gaatcgcctc tggtggattg gttggttagt ttcaaatctt ataccttaat       60

atatgggtta agaatgaatc attctctgag tataatctaa ttatttttga gttacacaga      120

tgtggtggta tctttacatt ttttgtgttt gtgatttaga tctgctactg aactttttga      180

ggcatatagc atggcagaaa tgacattcaa tcctcctgtt gaatcttcaa accccaaaat      240

aaaggtatgg gatatttttc atttttttaa aggaagaaat agaaaccaat gtatctcaat      300

aactctaact ccagtttgct taattatttt ataggtagtt ttttttttaa tgtttaggat      360

ttcatcatag gatggatttc tgaggttgaa attctataga gatgatcatg aaactgttcg      420

ttcaatatag gatatgtcca agaccttacc aagcatctgt cattgtgttg catgtgttgg      480

tgtcagctgt tgccattttc aacttggttc acaggttggc tttagcttat agcataagta      540

acttctaact catactttaa atattttcct agggtaaatt tttacaaggg gattcatttt      600

tgaatgaaga tttaaatcag ctaatcaaaa gatactccag tgaagttgct actgaatcgc      660

ctcttgactt taccaagtac ctcaagacaa gtcttcacgc ggccgccggg ggcacgggaa      720

gtggtggatc agccggtggc actggtggct ctgccggagg gtcagcggga gcagggggag      780

ccacaggcgg atctacggct ggaggggcga caacggcctc tgcgatcgct ttggaagtgc      840

ttttccaggg gcctggagct agcggaagcg gaggatcaaa gggagaggaa ctctttaccg      900

gcgtcgttcc aatccttgtt gaactggatg gggacgtgaa tgggcataaa ttttcagtat      960

caggggaagg ggaaggcgac gctacatatg gaaaattgac tctcaaattc atatgcacta     1020

ctggtaaatt gcccgtgcct tggcctacac tcgtcacgac cttcgggtat ggtgttcaat     1080

gtttcgccag gtatccggat catatgaaac aacacgattt cttcaaatca gcgatgccgg     1140

aagggtatgt gcaggagcga acaatctttt tcaaggacga cggcaactat aaaacacggg     1200

ccgaagtcaa atttgaggga gatacgctcg ttaatcggat agagctgaag ggcatcgact     1260

ttaaggagga tgggaacatc ttgggccata agctggaata taattataac agccacaacg     1320

tttacattat ggccgacaaa cagaagaatg gtattaaggt gaattttaaa ataaggcaca     1380

acatagaaga cggatctgtg caactggccg accactatca gcagaatacg cctattggcg     1440

atggtccagt gcttctccct gacaaccatt acctcagtac gcaaagtgct ctctctaaag     1500

accccaacga aaaacgcgat cacatggtac tgctggagtt cgtaaccgcc gcaggaataa     1560

ctcatggaat ggatgaactc tacaaggttg acttggataa aggcgcgccc ggaagttcct     1620

attctctaga aagtatagga acttcggggt ctggcgaagg cagaggctcc cttttgacat     1680

gcggagacgt cgaggagaac ccgggtccca tggagacaga cacactcctg ctatgggtac     1740

tgctcctctg ggttccaggt tccactggcg acggcggacc gaccgccaac acctcctcca     1800

cctccaccaa cggcaacagc attttggaca tacgccaagg cccgaaagag ccatttcgcg     1860

attacgtaga tcggttctac aaaacgctgc gagcggagca agcatcacaa gaggttaaaa     1920

attggatgac ggagacattg cttgttcaaa acgcgaaccc agattgtaaa acaattttga     1980

aagcccttgg acctggtgct acgctcgagg aaatgatgac agcatgccaa ggcgttggtg     2040

gaccaggagg aagtaccgga ggaagcatcc ttgatatacg acaaggtcct aaggagcctt     2100

ttcgcgacta cgttgaccgc ttttataaga cgcttcgcgc tgaacaggcg tctcaggagg     2160

tcaagaattg gatgacagag acattgcttg tacaaaatgc taatcccgac tgtaaaacga     2220

ttctcaaggc gctgggaccg ggagccactc ttgaagaaat gatgactgcg tgtcaaggag     2280

taggaggaaa ctcctccaac tccgccacca acacctccgc caccaccggt ggcgaaaatc     2340

tgtattttca gggagccgcg gcctctaatt ccgctgacgg tgacggttca aatgctacag     2400

ggagttctgc tggtgctggc tctggaacga gtggcgggga caacacgagt gatggctccg     2460

gggcgagtgc cggtgcagcc agcacaaatt caaatgggaa cacgggtagt gcgacttctg     2520

ggggggccac aggtagcgat acgtcaggag cgacggctgg tagtggggct tccgacggcg     2580

gaaacggcgc aacagcgtca tcaactacag gcaacggaaa ttcaagcggt acaaccgcga     2640

cgaccggagg cggtgatgca ggggggtcga ctaatgctgt gggccaggac acgcaggagg     2700

tcatcgtggt gccacactcc ttgcccttta aggtggtggt gatctcagcc atcctggccc     2760

tggtggtgct caccatcatc tcccttatca tcctcatcat gctttggcag aagaagccac     2820

gttaggcgcg caataatgga agttcctatt ctctagaaag tataggaact tcgtaagccg     2880

gctacttgct ttaaaaaacc tcccacacct ccccctgaac ctgaaacata aaatgaatgc     2940

aattgttgtt gttaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     3000

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     3060

catcaatgta tcttaacgcg tttcgaatta attaactctg gatttcacga aatatttgaa     3120

aacatcacta cactagtaga ggaatgaagt cagtggactt tcttgtatat ttgtgtgtgc     3180

agatgtacat aaagatgagt tgttaactta ggatcttttc tttttataca aggaaagctt     3240

cctaagaatg tctaggaaga agaggaagaa tgaccctttg catggcacag ggttctgccc     3300

ctattctgaa tatgtcattc catcaaggag atcaaaagcc tttttttctc cccagtattt     3360

ggaaattact ttcttgatga tgctgccttt taaaagcttc acgtacatta tagtttttta     3420

aaaaaatctt tggactggat cttactgaag tgcagttgct atattaaaat tagggcatag     3480

agcacagaaa aatcaagacc atgagaagac attttaccat ttagctactt tttataacta     3540

aatactcttt aaatattttt atttcaatac tgtggatgga aatgagaagc attctaaatt     3600

tgagttaata tatttttatg aagatatttg agaaaagaaa aaaatagctt gtattcaggt     3660

tcattggctt ttgctggatg atccacctaa agaagttacc taatttggcc ttttaagttg     3720

ctactgaatc gcctctgg                                                   3738


<210>  18
<211>  3844
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  18
acctaccact tcccatgttg gggcctccaa aaactcacta cttaagacta attggatcaa       60

agtgtttacc agttggaaaa atcttgcata agtctgcatt ataaaatgtg tttaaagaat      120

tacaatttaa ttatttttat gtatatacgt aagctcttac tgcctaagaa ttctttccaa      180

atataaggcc tagggctact tgaataattt gtaatataca attaatgtgt tgtcctttaa      240

aaatttttaa ttttctttaa taggtaaaac tgtatccctt tcaaacttat gtatcttggc      300

agatgcttta tagaaagtgc aacagcatat tatgtctcaa ccaaatttaa atgatagctt      360

ttaatgtttt aataaactgt atcatagtat agtagtgaaa caacgttggt ccctttactc      420

actctcaatg caagttaact gctcacccat aattcctttt gtaatgaaaa tcattagtat      480

ttaattaggt ttagctatga tgtgaaataa ttatatttat ttatgttttc ttgtcttttt      540

ctctcctttt acacagctac ttctgagtgg aggagcagac aataaattgt attcctacag      600

atattcacct accacttccc atgttggtgc agcggccgcc ggaggtactg gatcaggtgg      660

atcagcagga ggcggtactg gaggttctgc tggcggttca gctggtgcgg gcgcgacggg      720

tggaagtaca gccggaggtg ccacgacagc gtcccatcac caccatcacc atcatcatca      780

tcattatcca tatgacgtac ctgattatgc ggcgatcgct ggcgagaacc tgtattttca      840

agggagctcg agtccttcaa gacttgagga agaattgaga cggagactta ccgagcccgg      900

cgcacagagt ggtttggagg tgcttttcca gggaccaggt gctagcggaa gcggaatggt      960

cagtaagggt gaggaggaca acatggctat aatcaaagag tttatgcggt ttaaggtcca     1020

tatggaaggt tcagttaatg gacatgagtt cgagatagaa ggtgagggtg aggggcgacc     1080

gtacgaaggc acacaaaccg caaagttgaa agtcaccaaa ggtggaccct tgccctttgc     1140

ttgggatatt ctctcccctc aattcatgta cggcagtaag gcatacgtca aacatcccgc     1200

tgacatcccc gactatctga agctgtcttt ccctgagggt tttaaatggg agcgagtgat     1260

gaacttcgag gacgggggag tggtaacagt gactcaagat tcctctttgc aggacgggga     1320

gttcatatat aaagtgaaac tgcggggtac gaactttcca agtgacggtc ccgtaatgca     1380

gaagaagacg atgggatggg aggcaagcag cgagcgaatg tatcctgagg atggagccct     1440

taagggagaa attaagcaac ggctgaagtt gaaagatggt ggacattatg atgctgaggt     1500

taaaacaact tataaagcca agaaaccagt tcagttgcca ggggcgtata acgtcaacat     1560

taaactggac attacatctc acaatgaaga ttacacaatc gttgagcaat atgaacgcgc     1620

ggagggtcgg cactcaacgg gtggcatgga cgagttgtat aaaggcgcgc ccataacttc     1680

gtatagcata cattatacga agttatctgg gtctggcgaa ggcagaggct cccttttgac     1740

atgcggagac gtcgaggaga acccgggtcc catggagaca gacacactcc tgctatgggt     1800

actgctcctc tgggttccag gttccactgg cgacggcgga ccgtctaaca cagcaaatgg     1860

gactagcacc acgaacgcat atccttacga cgttcctgat tacgcttcat ctggtggaag     1920

tggcaccgga gggacttatc cgtacgacgt acctgactat gcttccacaa gcggggggac     1980

tggtggtggc agttatccct acgacgttcc cgattatgcg ggcacaggtt ccgggagtac     2040

tggtggctcc tatccttatg atgtccccga ttatgcgtcc agcggcggcg gctctactac     2100

agggggttat ccctatgatg ttccagatta cgccacttca ggttccggga ctggatctgg     2160

aggataccct tatgatgtac cagattacgc tactagtggc tctggcacag gaggcggttc     2220

atacccctac gatgttccgg actacgcggg atctgggagc ggcagcacga ccagtggtta     2280

tccctatgac gttccagact acgccgggac gggaacaggg agttcctccg gcgggtatcc     2340

atatgacgta ccagattatg cgacctctag cggaaccggg ggttctggag ggtatccgta     2400

tgacgtgcct gactacgcca atactacatc taacactagt gcatccgcga atagtaccgg     2460

tggcgaaaat ctgtattttc agggagccgc ggcctctaat tccgctgacg gtgacggttc     2520

aaatgctaca gggagttctg ctggtgctgg ctctggaacg agtggcgggg acaacacgag     2580

tgatggctcc ggggcgagtg ccggtgcagc cagcacaaat tcaaatggga acacgggtag     2640

tgcgacttct gggggggcca caggtagcga tacgtcagga gcgacggctg gtagtggggc     2700

ttccgacggc ggaaacggcg caacagcgtc atcaactaca ggcaacggaa attcaagcgg     2760

tacaaccgcg acgaccggag gcggtgatgc aggggggtcg actaatgctg tgggccagga     2820

cacgcaggag gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc     2880

catcctggcc ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca     2940

gaagaagcca cgttaggcgc gcaataatat aacttcgtat agcatacatt atacgaagtt     3000

ataagccggc tacttgcttt aaaaaacctc ccacacctcc ccctgaacct gaaacataaa     3060

atgaatgcaa ttgttgttgt taacttgttt attgcagctt ataatggtta caaataaagc     3120

aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg     3180

tccaaactca tcaatgtatc ttaacgcgtt tcgaattaat taatgaaagt gaacaataat     3240

ttgactatag agattatttc tgtaaatgaa attggtagag aaccatgaaa ttacatagat     3300

gcagatgcag aaagcagcct tttgaagttt atataatgtt ttcacccttc ataacagcta     3360

acgtatcact ttttcttatt ttgtatttat aataagatag gttgtgttta taaaatacaa     3420

actgtggcat acattctcta tacaaacttg aaattaaact gagttttaca tttctcttta     3480

aaggtattgg tttgaattca gatttgcttt tttattttta tttgtttttt ttttttttga     3540

gatggagtct tgctctgttg cctaggctgg agtgcagtgg cgcaatctca actcactgca     3600

acctccgctt cctaggttca atcgattctc ctgtctcaac ctcccaagta gctgggatta     3660

caggcacaca tcacgatgtc ctgctaattt ttgtattttt agtagagacg gggttttgcc     3720

atgttggcca ggctggtctt gaactcctga cctcaggtga tctgcccacc tcagcctccc     3780

aaagtgagcc actgtgcctg gccgaattaa gatttgtttt tacctaccac ttcccatgtt     3840

gggg                                                                  3844


<210>  19
<211>  3625
<212>  DNA
<213>  artificial sequence

<220>
<223>  insertion template

<400>  19
acctaccact tcccatgttg gggcctccaa aaactcacta cttaagacta attggatcaa       60

agtgtttacc agttggaaaa atcttgcata agtctgcatt ataaaatgtg tttaaagaat      120

tacaatttaa ttatttttat gtatatacgt aagctcttac tgcctaagaa ttctttccaa      180

atataaggcc tagggctact tgaataattt gtaatataca attaatgtgt tgtcctttaa      240

aaatttttaa ttttctttaa taggtaaaac tgtatccctt tcaaacttat gtatcttggc      300

agatgcttta tagaaagtgc aacagcatat tatgtctcaa ccaaatttaa atgatagctt      360

ttaatgtttt aataaactgt atcatagtat agtagtgaaa caacgttggt ccctttactc      420

actctcaatg caagttaact gctcacccat aattcctttt gtaatgaaaa tcattagtat      480

ttaattaggt ttagctatga tgtgaaataa ttatatttat ttatgttttc ttgtcttttt      540

ctctcctttt acacagctac ttctgagtgg aggagcagac aataaattgt attcctacag      600

atattcacct accacttccc atgttggtgc agcggccgcc ggaggtactg gatcaggtgg      660

atcagcagga ggcggtactg gaggttctgc tggcggttca gctggtgcgg gcgcgacggg      720

tggaagtaca gccggaggtg ccacgacagc gtcccatcac caccatcacc atcatcatca      780

tcattatcca tatgacgtac ctgattatgc ggcgatcgct ggcgagaacc tgtattttca      840

agggagctcg agtccttcaa gacttgagga agaattgaga cggagactta ccgagcccgg      900

cgcacagagt ggtttggagg tgcttttcca gggaccaggt gctagcggaa gcggaatggt      960

cagtaagggt gaggaggaca acatggctat aatcaaagag tttatgcggt ttaaggtcca     1020

tatggaaggt tcagttaatg gacatgagtt cgagatagaa ggtgagggtg aggggcgacc     1080

gtacgaaggc acacaaaccg caaagttgaa agtcaccaaa ggtggaccct tgccctttgc     1140

ttgggatatt ctctcccctc aattcatgta cggcagtaag gcatacgtca aacatcccgc     1200

tgacatcccc gactatctga agctgtcttt ccctgagggt tttaaatggg agcgagtgat     1260

gaacttcgag gacgggggag tggtaacagt gactcaagat tcctctttgc aggacgggga     1320

gttcatatat aaagtgaaac tgcggggtac gaactttcca agtgacggtc ccgtaatgca     1380

gaagaagacg atgggatggg aggcaagcag cgagcgaatg tatcctgagg atggagccct     1440

taagggagaa attaagcaac ggctgaagtt gaaagatggt ggacattatg atgctgaggt     1500

taaaacaact tataaagcca agaaaccagt tcagttgcca ggggcgtata acgtcaacat     1560

taaactggac attacatctc acaatgaaga ttacacaatc gttgagcaat atgaacgcgc     1620

ggagggtcgg cactcaacgg gtggcatgga cgagttgtat aaaggcgcgc ccataacttc     1680

gtatagcata cattatacga agttatctgg gtctggcgaa ggcagaggct cccttttgac     1740

atgcggagac gtcgaggaga acccgggtcc catggagaca gacacactcc tgctatgggt     1800

actgctcctc tgggttccag gttccactgg cgacggcgga ccgtctaaca cagcaaatgg     1860

gactagcacc acgaacgcag actacaagga cgacgacgat aagaccggca gcgattataa     1920

ggatgatgac gataagagtt ccggcgacta taaggacgac gatgataagg ggaccactga     1980

ttacaaagac gatgacgaca aaggcgggtc cgactataag gatgacgatg acaagagcgg     2040

aagtgattac aaagatgatg acgacaagac cgggactgat tataaagatg atgatgataa     2100

aggctccagt gattataaag acgacgacga caagggcagt ggagactaca aagacgacga     2160

tgacaagggt actggcgatt acaaggatga tgatgacaag aatactacat ctaacactag     2220

tgcatccgcg aatagtaccg gtggcgaaaa tctgtatttt cagggagccg cggcctctaa     2280

ttccgctgac ggtgacggtt caaatgctac agggagttct gctggtgctg gctctggaac     2340

gagtggcggg gacaacacga gtgatggctc cggggcgagt gccggtgcag ccagcacaaa     2400

ttcaaatggg aacacgggta gtgcgacttc tgggggggcc acaggtagcg atacgtcagg     2460

agcgacggct ggtagtgggg cttccgacgg cggaaacggc gcaacagcgt catcaactac     2520

aggcaacgga aattcaagcg gtacaaccgc gacgaccgga ggcggtgatg caggggggtc     2580

gactaatgct gtgggccagg acacgcagga ggtcatcgtg gtgccacact ccttgccctt     2640

taaggtggtg gtgatctcag ccatcctggc cctggtggtg ctcaccatca tctcccttat     2700

catcctcatc atgctttggc agaagaagcc acgttaggcg cgcaataata taacttcgta     2760

tagcatacat tatacgaagt tataagccgg ctacttgctt taaaaaacct cccacacctc     2820

cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt tattgcagct     2880

tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc atttttttca     2940

ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttaacgcgt ttcgaattaa     3000

ttaatgaaag tgaacaataa tttgactata gagattattt ctgtaaatga aattggtaga     3060

gaaccatgaa attacataga tgcagatgca gaaagcagcc ttttgaagtt tatataatgt     3120

tttcaccctt cataacagct aacgtatcac tttttcttat tttgtattta taataagata     3180

ggttgtgttt ataaaataca aactgtggca tacattctct atacaaactt gaaattaaac     3240

tgagttttac atttctcttt aaaggtattg gtttgaattc agatttgctt ttttattttt     3300

atttgttttt tttttttttg agatggagtc ttgctctgtt gcctaggctg gagtgcagtg     3360

gcgcaatctc aactcactgc aacctccgct tcctaggttc aatcgattct cctgtctcaa     3420

cctcccaagt agctgggatt acaggcacac atcacgatgt cctgctaatt tttgtatttt     3480

tagtagagac ggggttttgc catgttggcc aggctggtct tgaactcctg acctcaggtg     3540

atctgcccac ctcagcctcc caaagtgagc cactgtgcct ggccgaatta agatttgttt     3600

ttacctacca cttcccatgt tgggg                                           3625


<210>  20
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  sgRNA sequence

<400>  20
gucccaccug ggaaccucgc                                                   20


<210>  21
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  sgRNA sequence

<400>  21
agaccucacc gccucaucgu                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  sgRNA sequence

<400>  22
aguugcuacu gaaucgccuc                                                   20


<210>  23
<211>  20
<212>  RNA
<213>  artificial sequence

<220>
<223>  sgRNA sequence

<400>  23
accuaccacu ucccauguug                                                   20


<210>  24
<211>  2064
<212>  DNA
<213>  artificial sequence

<220>
<223>  modified recombinase sequence

<400>  24
atgccacaat ttgatatatt atgtaaaaca ccacctaagg tgcttgttcg tcagtttgtg       60

gaaaggtttg aaagaccttc aggtgagaaa atagcattat gtgctgctga actaacctat      120

ttatgttgga tgattacaca taacggaaca gcaatcaaga gagccacatt catgagctat      180

aatactatca taagcaattc gctgagtttg gatattgtca acaagtcact gcagtttaaa      240

tacaagacgc aaaaagcaac aattctggaa gcctcattaa agaaattgat acctgcttgg      300

gaatttacaa ttattcctta ctatggacaa aaacatcaat ctgatatcac tgatattgta      360

agtagtttgc aattacagtt cgaatcatcg gaagaagcag ataagggaaa tagccacagt      420

aaaaaaatgc ttaaagcact tctaagtgag ggtgaaagca tctgggagat cactgagaaa      480

atactaaatt cgtttgagta tacttcgaga tttacaaaaa caaaaacttt ataccaattc      540

ctcttcctag ctactttcat caattgtgga agattcagcg atattaagaa cgttgatccg      600

aaatcattta aattagtcca aaataagtat ctgggagtaa taatccagtg tttagtgaca      660

gagacaaaga caagcgttag taggcacata tacttcttta gcgcaagggg taggatcgat      720

ccacttgtat atttggatga atttttgagg aattctgaac cagtcctaaa acgagtaaat      780

aggaccggca attcttcaag caacaaacag gaataccaat tattaaaaga taacttagtc      840

agatcgtaca acaaagcttt gaagaaaaat gcgccttatt caatctttgc tataaaaaat      900

ggcccaaaat ctcacattgg aagacatttg atgacctcat ttctttcaat gaagggccta      960

acggagttga ctaatgttgt gggaaattgg agcgataagc gtgcttctgc cgtggccagg     1020

acaacgtata ctcatcagat aacagcaata cctgatcact acttcgctct agtttctcgg     1080

tactatgctt atgatccaat atcaaaggaa atgatagcat tgaaggatga gactaatcca     1140

attgaggagt ggcagcatat agaacagcta aagggtagtg ctgaaggaag catacgatac     1200

cccgcatgga atgggataat atcacaggag gtactagact acctttcatc ctacataaat     1260

agacgcatag cggccgccgg aagcggagcc actaacttct ccctgttgaa acaagcaggg     1320

gatgtcgaag agaatcccgg gccaaccggt ggcgcgcctg gtatgagcga gctgattaag     1380

gagaacatgc acatgaagct gtacatggag ggcaccgtgg acaaccatca cttcaagtgc     1440

acatccgagg gcgaaggcaa gccttacgag ggcacccaga ccatgagaat caaggtggtc     1500

gagggcggcc ctctcccctt cgccttcgac atcctggcta ctagcttcct ctacggcagc     1560

aagaccttca tcaaccacac ccagggcatc cccgacttct tcaagcagtc cttccctgag     1620

ggcttcacat gggagagagt caccacatac gaagacgggg gcgtgctgac cgctacccag     1680

gacaccagcc tccaggacgg ctgcctcatc tacaacgtca agatcagagg ggtgaacttc     1740

acatccaacg gccctgtgat gcagaagaaa acactcggct gggaggcctt caccgagacg     1800

ctgtaccccg ctgacggcgg cctggaaggc agaaacgaca tggccctgaa gctcgtgggc     1860

gggagccatc tgatcgcaaa cgccaagacc acatatagat ccaagaaacc cgctaagaac     1920

ctcaagatgc ctggcgtcta ctatgtggac tacagactgg aaagaatcaa ggaggccaac     1980

aacgagacct acgtcgagca gcacgaggtg gcagtggcca gatactgcga cctgcctagc     2040

aaactggggc acaaacttaa ttaa                                            2064


