                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  TARGETING OF THE CYTOSKELETON AS A THERAPEUTIC APPROACH FOR 
       NEURODEGENERATIVE DISEASE

<130>  U0120.70126WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/887,439
<151>  2019-08-15

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Ala Ser Leu Ser Ala Val Val Val Ala Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Ala Val Pro Pro Ala Pro Pro Leu Pro Gly Asp Ser Gly Thr Val 
            20                  25                  30          


Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly Val Val Pro 
        35                  40                  45              


Pro Ser Pro Pro Leu Pro Pro Gly Thr Cys Ile Pro Pro Pro Pro Pro 
    50                  55                  60                  


Leu Pro Gly Gly Ala Cys Ile Pro Pro Pro Pro Gln Leu Pro Gly Ser 
65                  70                  75                  80  


Ala Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly Val Ala Ser Ile Pro 
                85                  90                  95      


Pro Pro Pro Pro Leu Pro Gly Ala Thr Ala Ile Pro Pro Pro Pro Pro 
            100                 105                 110         


Leu Pro Gly Ala Thr Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly Gly 
        115                 120                 125             


Thr Gly Ile Pro Pro Pro Pro Pro Pro Leu Pro Gly Ser Val Gly Val 
    130                 135                 140                 


Pro Pro Pro Pro Pro Leu Pro Gly Gly Pro Gly Leu Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Pro Phe Pro Gly Ala Pro Gly Ile Pro Pro Pro Pro Pro Gly Met 
                165                 170                 175     


Gly Val Pro Pro Pro Pro Pro Phe Gly Phe Gly Val Pro Ala Ala Pro 
            180                 185                 190         


Val Leu Pro Phe Gly Leu Thr Pro 
        195                 200 


<210>  2
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Lys Lys Val Tyr Lys Pro Glu Val Gln Leu Arg Arg Pro Asn Trp Ser 
1               5                   10                  15      


Lys Phe Val Ala Glu Asp Leu Ser Gln Asp Cys Phe Trp Thr Lys Val 
            20                  25                  30          


Lys Glu Asp Arg Phe Glu Asn Asn Glu Leu Phe Ala Lys Leu Thr Leu 
        35                  40                  45              


Ala Phe Ser Ala Gln Thr Lys Thr Ser Lys Ala Lys Lys Asp Gln Glu 
    50                  55                  60                  


Gly Gly Glu Glu Lys Lys Ser Val Gln Lys Lys Lys Val Lys Glu Leu 
65                  70                  75                  80  


Lys Val Leu Asp Ser Lys Thr Ala Gln Asn Leu Ser Ile Phe Leu Gly 
                85                  90                  95      


Ser Phe Arg Met Pro Tyr Gln Glu Ile Lys Asn Val Ile Leu Glu Val 
            100                 105                 110         


Asn Glu Ala Val Leu Thr Glu Ser Met Ile Gln Asn Leu Ile Lys Gln 
        115                 120                 125             


Met Pro Glu Pro Glu Gln Leu Lys Met Leu Ser Glu Leu Lys Glu Glu 
    130                 135                 140                 


Tyr Asp Asp Leu Ala Glu Ser Glu Gln Phe Gly Val Val Met Gly Thr 
145                 150                 155                 160 


Val Pro Arg Leu Arg Pro Arg Leu Asn Ala Ile Leu Phe Lys Leu Gln 
                165                 170                 175     


Phe Ser Glu Gln Val Glu Asn Ile Lys Pro Glu Ile Val Ser Val Thr 
            180                 185                 190         


Ala Ala Cys Glu Glu Leu Arg Lys Ser Glu Asn Phe Ser Ser Leu Leu 
        195                 200                 205             


Glu Leu Thr Leu Leu Val Gly Asn Tyr Met Asn Ala Gly Ser Arg Asn 
    210                 215                 220                 


Ala Gly Ala Phe Gly Phe Asn Ile Ser Phe Leu Cys Lys Leu Arg Asp 
225                 230                 235                 240 


Thr Lys Ser Ala Asp Gln Lys Met Thr Leu Leu His Phe Leu Ala Glu 
                245                 250                 255     


Leu Cys Glu Asn Asp His Pro Glu Val Leu Lys Phe Pro Asp Glu Leu 
            260                 265                 270         


Ala His Val Glu Lys Ala Ser Arg Val Ser Ala Glu Asn Leu Gln Lys 
        275                 280                 285             


Ser Leu Asp Gln Met Lys Lys Gln Ile Ala Asp Val Glu Arg Asp Val 
    290                 295                 300                 


Gln Asn Phe Pro Ala Ala Thr Asp Glu Lys Asp Lys Phe Val Glu Lys 
305                 310                 315                 320 


Met Thr Ser Phe Val Lys Asp Ala Gln Glu Gln Tyr Asn Lys Leu Arg 
                325                 330                 335     


Met Met His Ser Asn Met Glu Thr Leu Tyr Lys Glu Leu Gly Asp Tyr 
            340                 345                 350         


Phe Val Phe Asp Pro Lys Lys Leu Ser Val Glu Glu Phe Phe Met Asp 
        355                 360                 365             


Leu His Asn Phe Arg Asn Met Phe Leu Gln Ala Val Lys Glu Asn Gln 
    370                 375                 380                 


Lys Arg Arg Glu Thr Glu Glu Lys Met Arg Arg Ala Lys Leu Ala Lys 
385                 390                 395                 400 


Glu Lys Ala Glu Lys Glu Arg Leu Glu Lys Gln Gln Lys Arg Glu Gln 
                405                 410                 415     


Leu Ile Asp Met Asn Ala Glu Gly Asp Glu Thr Gly Val Met Asp 
            420                 425                 430     


<210>  3
<211>  631
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Ala Ser Leu Ser Ala Val Val Val Ala Pro Ser Val Ser Ser Ser 
1               5                   10                  15      


Ala Ala Val Pro Pro Ala Pro Pro Leu Pro Gly Asp Ser Gly Thr Val 
            20                  25                  30          


Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Gly Gly Val Val Pro 
        35                  40                  45              


Pro Ser Pro Pro Leu Pro Pro Gly Thr Cys Ile Pro Pro Pro Pro Pro 
    50                  55                  60                  


Leu Pro Gly Gly Ala Cys Ile Pro Pro Pro Pro Gln Leu Pro Gly Ser 
65                  70                  75                  80  


Ala Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly Val Ala Ser Ile Pro 
                85                  90                  95      


Pro Pro Pro Pro Leu Pro Gly Ala Thr Ala Ile Pro Pro Pro Pro Pro 
            100                 105                 110         


Leu Pro Gly Ala Thr Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly Gly 
        115                 120                 125             


Thr Gly Ile Pro Pro Pro Pro Pro Pro Leu Pro Gly Ser Val Gly Val 
    130                 135                 140                 


Pro Pro Pro Pro Pro Leu Pro Gly Gly Pro Gly Leu Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Pro Phe Pro Gly Ala Pro Gly Ile Pro Pro Pro Pro Pro Gly Met 
                165                 170                 175     


Gly Val Pro Pro Pro Pro Pro Phe Gly Phe Gly Val Pro Ala Ala Pro 
            180                 185                 190         


Val Leu Pro Phe Gly Leu Thr Pro Lys Lys Val Tyr Lys Pro Glu Val 
        195                 200                 205             


Gln Leu Arg Arg Pro Asn Trp Ser Lys Phe Val Ala Glu Asp Leu Ser 
    210                 215                 220                 


Gln Asp Cys Phe Trp Thr Lys Val Lys Glu Asp Arg Phe Glu Asn Asn 
225                 230                 235                 240 


Glu Leu Phe Ala Lys Leu Thr Leu Ala Phe Ser Ala Gln Thr Lys Thr 
                245                 250                 255     


Ser Lys Ala Lys Lys Asp Gln Glu Gly Gly Glu Glu Lys Lys Ser Val 
            260                 265                 270         


Gln Lys Lys Lys Val Lys Glu Leu Lys Val Leu Asp Ser Lys Thr Ala 
        275                 280                 285             


Gln Asn Leu Ser Ile Phe Leu Gly Ser Phe Arg Met Pro Tyr Gln Glu 
    290                 295                 300                 


Ile Lys Asn Val Ile Leu Glu Val Asn Glu Ala Val Leu Thr Glu Ser 
305                 310                 315                 320 


Met Ile Gln Asn Leu Ile Lys Gln Met Pro Glu Pro Glu Gln Leu Lys 
                325                 330                 335     


Met Leu Ser Glu Leu Lys Glu Glu Tyr Asp Asp Leu Ala Glu Ser Glu 
            340                 345                 350         


Gln Phe Gly Val Val Met Gly Thr Val Pro Arg Leu Arg Pro Arg Leu 
        355                 360                 365             


Asn Ala Ile Leu Phe Lys Leu Gln Phe Ser Glu Gln Val Glu Asn Ile 
    370                 375                 380                 


Lys Pro Glu Ile Val Ser Val Thr Ala Ala Cys Glu Glu Leu Arg Lys 
385                 390                 395                 400 


Ser Glu Asn Phe Ser Ser Leu Leu Glu Leu Thr Leu Leu Val Gly Asn 
                405                 410                 415     


Tyr Met Asn Ala Gly Ser Arg Asn Ala Gly Ala Phe Gly Phe Asn Ile 
            420                 425                 430         


Ser Phe Leu Cys Lys Leu Arg Asp Thr Lys Ser Ala Asp Gln Lys Met 
        435                 440                 445             


Thr Leu Leu His Phe Leu Ala Glu Leu Cys Glu Asn Asp His Pro Glu 
    450                 455                 460                 


Val Leu Lys Phe Pro Asp Glu Leu Ala His Val Glu Lys Ala Ser Arg 
465                 470                 475                 480 


Val Ser Ala Glu Asn Leu Gln Lys Ser Leu Asp Gln Met Lys Lys Gln 
                485                 490                 495     


Ile Ala Asp Val Glu Arg Asp Val Gln Asn Phe Pro Ala Ala Thr Asp 
            500                 505                 510         


Glu Lys Asp Lys Phe Val Glu Lys Met Thr Ser Phe Val Lys Asp Ala 
        515                 520                 525             


Gln Glu Gln Tyr Asn Lys Leu Arg Met Met His Ser Asn Met Glu Thr 
    530                 535                 540                 


Leu Tyr Lys Glu Leu Gly Asp Tyr Phe Val Phe Asp Pro Lys Lys Leu 
545                 550                 555                 560 


Ser Val Glu Glu Phe Phe Met Asp Leu His Asn Phe Arg Asn Met Phe 
                565                 570                 575     


Leu Gln Ala Val Lys Glu Asn Gln Lys Arg Arg Glu Thr Glu Glu Lys 
            580                 585                 590         


Met Arg Arg Ala Lys Leu Ala Lys Glu Lys Ala Glu Lys Glu Arg Leu 
        595                 600                 605             


Glu Lys Gln Gln Lys Arg Glu Gln Leu Ile Asp Met Asn Ala Glu Gly 
    610                 615                 620                 


Asp Glu Thr Gly Val Met Asp 
625                 630     


<210>  4
<211>  1419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Glu Gly Thr His Cys Thr Leu Gln Leu His Lys Pro Ile Thr Glu 
1               5                   10                  15      


Leu Cys Tyr Ile Ser Phe Cys Leu Pro Lys Gly Glu Val Arg Gly Phe 
            20                  25                  30          


Ser Tyr Lys Gly Thr Val Thr Leu Asp Arg Ser Asn Lys Gly Phe His 
        35                  40                  45              


Asn Cys Tyr Gln Val Arg Glu Glu Ser Asp Ile Ile Ser Leu Ser Gln 
    50                  55                  60                  


Glu Pro Asp Glu His Pro Gly Asp Ile Phe Phe Lys Gln Thr Pro Thr 
65                  70                  75                  80  


Lys Asp Ile Leu Thr Glu Leu Tyr Lys Leu Thr Thr Glu Arg Glu Arg 
                85                  90                  95      


Leu Leu Thr Asn Leu Leu Ser Ser Asp His Ile Leu Gly Ile Thr Met 
            100                 105                 110         


Gly Asn Gln Glu Gly Lys Leu Gln Glu Leu Ser Val Ser Leu Ala Pro 
        115                 120                 125             


Glu Asp Asp Cys Phe Gln Ser Ala Gly Asp Trp Gln Gly Glu Leu Pro 
    130                 135                 140                 


Val Gly Pro Leu Asn Lys Arg Ser Thr His Gly Asn Lys Lys Pro Arg 
145                 150                 155                 160 


Arg Ser Ser Gly Arg Arg Glu Ser Phe Gly Ala Leu Pro Gln Lys Arg 
                165                 170                 175     


Thr Lys Arg Lys Gly Arg Gly Gly Arg Glu Ser Ala Pro Leu Met Gly 
            180                 185                 190         


Lys Asp Lys Ile Cys Ser Ser His Ser Leu Pro Leu Ser Arg Thr Arg 
        195                 200                 205             


Pro Asn Leu Trp Val Leu Glu Glu Lys Gly Asn Leu Leu Pro Asn Gly 
    210                 215                 220                 


Ala Leu Ala Cys Ser Leu Gln Arg Arg Glu Ser Cys Pro Pro Asp Ile 
225                 230                 235                 240 


Pro Lys Thr Pro Asp Thr Asp Leu Gly Phe Gly Ser Phe Glu Thr Ala 
                245                 250                 255     


Phe Lys Asp Thr Gly Leu Gly Arg Glu Val Leu Pro Pro Asp Cys Ser 
            260                 265                 270         


Ser Thr Glu Ala Gly Gly Asp Gly Ile Arg Arg Pro Pro Ser Gly Leu 
        275                 280                 285             


Glu His Gln Gln Thr Gly Leu Ser Glu Ser His Gln Asp Pro Glu Lys 
    290                 295                 300                 


His Pro Glu Ala Glu Lys Asp Glu Met Glu Lys Pro Ala Lys Arg Thr 
305                 310                 315                 320 


Cys Lys Gln Lys Pro Val Ser Lys Val Val Ala Lys Val Gln Asp Leu 
                325                 330                 335     


Ser Ser Gln Val Gln Arg Val Val Lys Thr His Ser Lys Gly Lys Glu 
            340                 345                 350         


Thr Ile Ala Ile Arg Pro Ala Ala His Ala Glu Phe Val Pro Lys Ala 
        355                 360                 365             


Asp Leu Leu Thr Leu Pro Gly Ala Glu Ala Gly Ala His Gly Ser Arg 
    370                 375                 380                 


Arg Gln Gly Lys Glu Arg Gln Gly Asp Arg Ser Ser Gln Ser Pro Ala 
385                 390                 395                 400 


Gly Glu Thr Ala Ser Ile Ser Ser Val Ser Ala Ser Ala Glu Gly Ala 
                405                 410                 415     


Val Asn Lys Val Pro Leu Lys Val Ile Glu Ser Glu Lys Leu Asp Glu 
            420                 425                 430         


Ala Pro Glu Gly Lys Arg Leu Gly Phe Pro Val His Thr Ser Val Pro 
        435                 440                 445             


His Thr Arg Pro Glu Thr Arg Asn Lys Arg Arg Ala Gly Leu Pro Leu 
    450                 455                 460                 


Gly Gly His Lys Ser Leu Phe Leu Asp Leu Pro His Lys Val Gly Pro 
465                 470                 475                 480 


Asp Ser Ser Gln Pro Arg Gly Asp Lys Lys Lys Pro Ser Pro Pro Ala 
                485                 490                 495     


Pro Ala Ala Leu Gly Lys Val Phe Asn Asn Ser Ala Ser Gln Ser Ser 
            500                 505                 510         


Thr His Lys Gln Thr Ser Pro Val Pro Ser Pro Leu Ser Pro Arg Leu 
        515                 520                 525             


Pro Ser Pro Gln Gln His His Arg Ile Leu Arg Leu Pro Ala Leu Pro 
    530                 535                 540                 


Gly Glu Arg Glu Ala Ala Leu Asn Asp Ser Pro Cys Arg Lys Ser Arg 
545                 550                 555                 560 


Val Phe Ser Gly Cys Val Ser Ala Asp Thr Leu Glu Pro Pro Ser Ser 
                565                 570                 575     


Ala Lys Val Thr Glu Thr Lys Gly Ala Ser Pro Ala Phe Leu Arg Ala 
            580                 585                 590         


Gly Gln Pro Arg Leu Val Pro Gly Glu Thr Leu Glu Lys Ser Leu Gly 
        595                 600                 605             


Pro Gly Lys Thr Thr Ala Glu Pro Gln His Gln Ser Pro Pro Gly Ile 
    610                 615                 620                 


Ser Ser Glu Gly Phe Pro Trp Asp Gly Phe Asn Glu Gln Thr Pro Lys 
625                 630                 635                 640 


Asp Leu Pro Asn Arg Asp Gly Gly Ala Trp Val Leu Gly Tyr Arg Ala 
                645                 650                 655     


Gly Pro Ala Cys Pro Phe Leu Leu His Glu Glu Arg Glu Lys Ser Asn 
            660                 665                 670         


Arg Ser Glu Leu Tyr Leu Asp Leu His Pro Asp His Ser Leu Thr Glu 
        675                 680                 685             


Gln Asp Asp Arg Thr Pro Gly Arg Leu Gln Ala Val Trp Pro Pro Pro 
    690                 695                 700                 


Lys Thr Lys Asp Thr Glu Glu Lys Val Gly Leu Lys Tyr Thr Glu Ala 
705                 710                 715                 720 


Glu Tyr Gln Ala Ala Ile Leu His Leu Lys Arg Glu His Lys Glu Glu 
                725                 730                 735     


Ile Glu Asn Leu Gln Ala Gln Phe Glu Leu Arg Ala Phe His Ile Arg 
            740                 745                 750         


Gly Glu His Ala Met Ile Thr Ala Arg Leu Glu Glu Thr Ile Glu Asn 
        755                 760                 765             


Leu Lys His Glu Leu Glu His Arg Trp Arg Gly Gly Cys Glu Glu Arg 
    770                 775                 780                 


Lys Asp Val Cys Ile Ser Thr Asp Asp Asp Cys Pro Pro Lys Thr Phe 
785                 790                 795                 800 


Arg Asn Val Cys Val Gln Thr Asp Arg Glu Thr Phe Leu Lys Pro Cys 
                805                 810                 815     


Glu Ser Glu Ser Lys Thr Thr Arg Ser Asn Gln Leu Val Pro Lys Lys 
            820                 825                 830         


Leu Asn Ile Ser Ser Leu Ser Gln Leu Ser Pro Pro Asn Asp His Lys 
        835                 840                 845             


Asp Ile His Ala Ala Leu Gln Pro Met Glu Gly Met Ala Ser Asn Gln 
    850                 855                 860                 


Gln Lys Ala Leu Pro Pro Pro Pro Ala Ser Ile Pro Pro Pro Pro Pro 
865                 870                 875                 880 


Leu Pro Ser Gly Leu Gly Ser Leu Ser Pro Ala Pro Pro Met Pro Pro 
                885                 890                 895     


Val Ser Ala Gly Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            900                 905                 910         


Leu Pro Pro Pro Ser Ser Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Leu Pro Asn Ser Pro Ala Pro Pro Asn Pro Gly Gly Pro Pro Pro 
    930                 935                 940                 


Ala Pro Pro Pro Pro Gly Leu Ala Pro Pro Pro Pro Pro Gly Leu Phe 
945                 950                 955                 960 


Phe Gly Leu Gly Ser Ser Ser Ser Gln Cys Pro Arg Lys Pro Ala Ile 
                965                 970                 975     


Glu Pro Ser Cys Pro Met Lys Pro Leu Tyr Trp Thr Arg Ile Gln Ile 
            980                 985                 990         


Ser Asp Arg Ser Gln Asn Ala Thr  Pro Thr Leu Trp Asp  Ser Leu Glu 
        995                 1000                 1005             


Glu Pro  Asp Ile Arg Asp Pro  Ser Glu Phe Glu Tyr  Leu Phe Ser 
    1010                 1015                 1020             


Lys Asp  Thr Thr Gln Gln Lys  Lys Lys Pro Leu Ser  Glu Thr Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Asn Lys Val Lys  Lys Ile Ile Lys Leu  Leu Asp Gly 
    1040                 1045                 1050             


Lys Arg  Ser Gln Thr Val Gly  Ile Leu Ile Ser Ser  Leu His Leu 
    1055                 1060                 1065             


Glu Met  Lys Asp Ile Gln Gln  Ala Ile Phe Asn Val  Asp Asp Ser 
    1070                 1075                 1080             


Val Val  Asp Leu Glu Thr Leu  Ala Ala Leu Tyr Glu  Asn Arg Ala 
    1085                 1090                 1095             


Gln Glu  Asp Glu Leu Val Lys  Ile Arg Lys Tyr Tyr  Glu Thr Ser 
    1100                 1105                 1110             


Lys Glu  Glu Glu Leu Lys Leu  Leu Asp Lys Pro Glu  Gln Phe Leu 
    1115                 1120                 1125             


His Glu  Leu Ala Gln Ile Pro  Asn Phe Ala Glu Arg  Ala Gln Cys 
    1130                 1135                 1140             


Ile Ile  Phe Arg Ser Val Phe  Ser Glu Gly Ile Thr  Ser Leu His 
    1145                 1150                 1155             


Arg Lys  Val Glu Ile Ile Thr  Arg Ala Ser Lys Asp  Leu Leu His 
    1160                 1165                 1170             


Val Lys  Ser Val Lys Asp Ile  Leu Ala Leu Ile Leu  Ala Phe Gly 
    1175                 1180                 1185             


Asn Tyr  Met Asn Gly Gly Asn  Arg Thr Arg Gly Gln  Ala Asp Gly 
    1190                 1195                 1200             


Tyr Ser  Leu Glu Ile Leu Pro  Lys Leu Lys Asp Val  Lys Ser Arg 
    1205                 1210                 1215             


Asp Asn  Gly Ile Asn Leu Val  Asp Tyr Val Val Lys  Tyr Tyr Leu 
    1220                 1225                 1230             


Arg Tyr  Tyr Asp Gln Glu Ala  Gly Thr Glu Lys Ser  Val Phe Pro 
    1235                 1240                 1245             


Leu Pro  Glu Pro Gln Asp Phe  Phe Leu Ala Ser Gln  Val Lys Phe 
    1250                 1255                 1260             


Glu Asp  Leu Ile Lys Asp Leu  Arg Lys Leu Lys Arg  Gln Leu Glu 
    1265                 1270                 1275             


Ala Ser  Glu Lys Gln Met Val  Val Val Cys Lys Glu  Ser Pro Lys 
    1280                 1285                 1290             


Glu Tyr  Leu Gln Pro Phe Lys  Asp Lys Leu Glu Glu  Phe Phe Gln 
    1295                 1300                 1305             


Lys Ala  Lys Lys Glu His Lys  Met Glu Glu Ser His  Leu Glu Asn 
    1310                 1315                 1320             


Ala Gln  Lys Ser Phe Glu Thr  Thr Val Arg Tyr Phe  Gly Met Lys 
    1325                 1330                 1335             


Pro Lys  Ser Gly Glu Lys Glu  Ile Thr Pro Ser Tyr  Val Phe Met 
    1340                 1345                 1350             


Val Trp  Tyr Glu Phe Cys Ser  Asp Phe Lys Thr Ile  Trp Lys Arg 
    1355                 1360                 1365             


Glu Ser  Lys Asn Ile Ser Lys  Glu Arg Leu Lys Met  Ala Gln Glu 
    1370                 1375                 1380             


Ser Val  Ser Lys Leu Thr Ser  Glu Lys Lys Val Glu  Thr Lys Lys 
    1385                 1390                 1395             


Ile Asn  Pro Thr Ala Ser Leu  Lys Glu Arg Leu Arg  Gln Lys Glu 
    1400                 1405                 1410             


Ala Ser  Val Thr Thr Asn 
    1415                 


<210>  5
<211>  1726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Gly Asn Gln Asp Gly Lys Leu Lys Arg Ser Ala Gly Asp Ala Leu 
1               5                   10                  15      


His Glu Gly Gly Gly Gly Ala Glu Asp Ala Leu Gly Pro Arg Asp Val 
            20                  25                  30          


Glu Ala Thr Lys Lys Gly Ser Gly Gly Lys Lys Ala Leu Gly Lys His 
        35                  40                  45              


Gly Lys Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ser Gly Lys Lys 
    50                  55                  60                  


Lys Ser Lys Ser Asp Ser Arg Ala Ser Val Phe Ser Asn Leu Arg Ile 
65                  70                  75                  80  


Arg Lys Asn Leu Ser Lys Gly Lys Gly Ala Gly Gly Ser Arg Glu Asp 
                85                  90                  95      


Val Leu Asp Ser Gln Ala Leu Gln Thr Gly Glu Leu Asp Ser Ala His 
            100                 105                 110         


Ser Leu Leu Thr Lys Thr Pro Asp Leu Ser Leu Ser Ala Asp Glu Ala 
        115                 120                 125             


Gly Leu Ser Asp Thr Glu Cys Ala Asp Pro Phe Glu Val Thr Gly Pro 
    130                 135                 140                 


Gly Gly Pro Gly Pro Ala Glu Ala Arg Val Gly Gly Arg Pro Ile Ala 
145                 150                 155                 160 


Glu Asp Val Glu Thr Ala Ala Gly Ala Gln Asp Gly Gln Arg Thr Ser 
                165                 170                 175     


Ser Gly Ser Asp Thr Asp Ile Tyr Ser Phe His Ser Ala Thr Glu Gln 
            180                 185                 190         


Glu Asp Leu Leu Ser Asp Ile Gln Gln Ala Ile Arg Leu Gln Gln Gln 
        195                 200                 205             


Gln Gln Gln Gln Leu Gln Leu Gln Leu Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Leu Gln Gly Ala Glu Glu Pro Ala Ala Pro Pro Thr Ala Val Ser 
225                 230                 235                 240 


Pro Gln Pro Gly Ala Phe Leu Gly Leu Asp Arg Phe Leu Leu Gly Pro 
                245                 250                 255     


Ser Gly Gly Ala Gly Glu Ala Pro Gly Ser Pro Asp Thr Glu Gln Ala 
            260                 265                 270         


Leu Ser Ala Leu Ser Asp Leu Pro Glu Ser Leu Ala Ala Glu Pro Arg 
        275                 280                 285             


Glu Pro Gln Gln Pro Pro Ser Pro Gly Gly Leu Pro Val Ser Glu Ala 
    290                 295                 300                 


Pro Ser Leu Pro Ala Ala Gln Pro Ala Ala Lys Asp Ser Pro Ser Ser 
305                 310                 315                 320 


Thr Ala Phe Pro Phe Pro Glu Ala Gly Pro Gly Glu Glu Ala Ala Gly 
                325                 330                 335     


Ala Pro Val Arg Gly Ala Gly Asp Thr Asp Glu Glu Gly Glu Glu Asp 
            340                 345                 350         


Ala Phe Glu Asp Ala Pro Arg Gly Ser Pro Gly Glu Glu Trp Ala Pro 
        355                 360                 365             


Glu Val Gly Glu Asp Ala Pro Gln Arg Leu Gly Glu Glu Pro Glu Glu 
    370                 375                 380                 


Glu Ala Gln Gly Pro Asp Ala Pro Ala Ala Ala Ser Leu Pro Gly Ser 
385                 390                 395                 400 


Pro Ala Pro Ser Gln Arg Cys Phe Lys Pro Tyr Pro Leu Ile Thr Pro 
                405                 410                 415     


Cys Tyr Ile Lys Thr Thr Thr Arg Gln Leu Ser Ser Pro Asn His Ser 
            420                 425                 430         


Pro Ser Gln Ser Pro Asn Gln Ser Pro Arg Ile Lys Arg Arg Pro Glu 
        435                 440                 445             


Pro Ser Leu Ser Arg Gly Ser Arg Thr Ala Leu Ala Ser Val Ala Ala 
    450                 455                 460                 


Pro Ala Lys Lys His Arg Ala Asp Gly Gly Leu Ala Ala Gly Leu Ser 
465                 470                 475                 480 


Arg Ser Ala Asp Trp Thr Glu Glu Leu Gly Ala Arg Thr Pro Arg Val 
                485                 490                 495     


Gly Gly Ser Ala His Leu Leu Glu Arg Gly Val Ala Ser Asp Ser Gly 
            500                 505                 510         


Gly Gly Val Ser Pro Ala Leu Ala Ala Lys Ala Ser Gly Ala Pro Ala 
        515                 520                 525             


Ala Ala Asp Gly Phe Gln Asn Val Phe Thr Gly Arg Thr Leu Leu Glu 
    530                 535                 540                 


Lys Leu Phe Ser Gln Gln Glu Asn Gly Pro Pro Glu Glu Ala Glu Lys 
545                 550                 555                 560 


Phe Cys Ser Arg Ile Ile Ala Met Gly Leu Leu Leu Pro Phe Ser Asp 
                565                 570                 575     


Cys Phe Arg Glu Pro Cys Asn Gln Asn Ala Gln Thr Asn Ala Ala Ser 
            580                 585                 590         


Phe Asp Gln Asp Gln Leu Tyr Thr Trp Ala Ala Val Ser Gln Pro Thr 
        595                 600                 605             


His Ser Leu Asp Tyr Ser Glu Gly Gln Phe Pro Arg Arg Val Pro Ser 
    610                 615                 620                 


Met Gly Pro Pro Ser Lys Pro Pro Asp Glu Glu His Arg Leu Glu Asp 
625                 630                 635                 640 


Ala Glu Thr Glu Asp Asp Gly Glu Ser Gln Ser Ala Val Ser Glu Thr 
                645                 650                 655     


Pro Gln Lys Arg Ser Asp Ala Val Gln Lys Glu Val Val Asp Met Lys 
            660                 665                 670         


Ser Glu Gly Gln Ala Thr Val Ile Gln Gln Leu Glu Gln Thr Ile Glu 
        675                 680                 685             


Asp Leu Arg Thr Lys Ile Ala Glu Leu Glu Arg Gln Tyr Pro Ala Leu 
    690                 695                 700                 


Asp Thr Glu Val Ala Ser Gly His Gln Gly Leu Glu Asn Gly Val Thr 
705                 710                 715                 720 


Ala Ser Gly Asp Val Cys Leu Glu Ala Leu Arg Leu Glu Glu Lys Glu 
                725                 730                 735     


Val Arg His His Arg Ile Leu Glu Ala Lys Ser Ile Gln Thr Ser Pro 
            740                 745                 750         


Thr Glu Glu Gly Gly Val Leu Thr Leu Pro Pro Val Asp Gly Leu Pro 
        755                 760                 765             


Gly Arg Pro Pro Cys Pro Pro Gly Ala Glu Ser Gly Pro Gln Thr Lys 
    770                 775                 780                 


Phe Cys Ser Glu Ile Ser Leu Ile Val Ser Pro Arg Arg Ile Ser Val 
785                 790                 795                 800 


Gln Leu Asp Ser His Gln Pro Thr Gln Ser Ile Ser Gln Pro Pro Pro 
                805                 810                 815     


Pro Pro Ser Leu Leu Trp Ser Ala Gly Gln Gly Gln Pro Gly Ser Gln 
            820                 825                 830         


Pro Pro His Ser Ile Ser Thr Glu Phe Gln Thr Ser His Glu His Ser 
        835                 840                 845             


Val Ser Ser Ala Phe Lys Asn Ser Cys Asn Ile Pro Ser Pro Pro Pro 
    850                 855                 860                 


Leu Pro Cys Thr Glu Ser Ser Ser Ser Met Pro Gly Leu Gly Met Val 
865                 870                 875                 880 


Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Thr Val Pro Thr Leu Pro 
                885                 890                 895     


Ser Thr Ala Ile Pro Gln Pro Pro Pro Leu Gln Gly Thr Glu Met Leu 
            900                 905                 910         


Pro Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro Pro Pro 
        915                 920                 925             


Pro Leu Pro Gly Ala Gly Ile Leu Pro Leu Pro Pro Leu Pro Gly Ala 
    930                 935                 940                 


Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Ala Ile Pro Pro Pro 
945                 950                 955                 960 


Pro Pro Leu Pro Gly Ala Gly Ile Pro Leu Pro Pro Pro Leu Pro Gly 
                965                 970                 975     


Ala Gly Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Gly Ile Pro Pro 
            980                 985                 990         


Pro Pro Pro Leu Pro Gly Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
        995                 1000                 1005             


Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile 
    1010                 1015                 1020             


Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro 
    1025                 1030                 1035             


Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1040                 1045                 1050             


Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Leu Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro 
    1070                 1075                 1080             


Leu Pro  Gly Ala Gly Ile Pro  Pro Pro Pro Pro Leu  Pro Gly Ala 
    1085                 1090                 1095             


Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly Val Gly  Ile Pro Pro 
    1100                 1105                 1110             


Pro Pro  Pro Leu Pro Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu 
    1115                 1120                 1125             


Pro Gly  Ala Gly Ile Pro Pro  Pro Pro Pro Leu Pro  Gly Ala Gly 
    1130                 1135                 1140             


Ile Pro  Pro Pro Pro Pro Leu  Pro Arg Val Gly Ile  Pro Pro Pro 
    1145                 1150                 1155             


Pro Pro  Leu Pro Gly Ala Gly  Ile Pro Pro Pro Pro  Pro Leu Pro 
    1160                 1165                 1170             


Gly Ala  Gly Ile Pro Pro Pro  Pro Pro Leu Pro Gly  Val Gly Ile 
    1175                 1180                 1185             


Pro Pro  Pro Pro Pro Leu Pro  Gly Val Gly Ile Pro  Pro Pro Pro 
    1190                 1195                 1200             


Pro Leu  Pro Gly Ala Gly Ile  Pro Pro Pro Pro Pro  Leu Pro Gly 
    1205                 1210                 1215             


Met Gly  Ile Pro Pro Ala Pro  Ala Pro Pro Leu Pro  Pro Pro Gly 
    1220                 1225                 1230             


Thr Gly  Ile Pro Pro Pro Pro  Leu Leu Pro Val Ser  Gly Pro Pro 
    1235                 1240                 1245             


Leu Leu  Pro Gln Val Gly Ser  Ser Thr Leu Pro Thr  Pro Gln Val 
    1250                 1255                 1260             


Cys Gly  Phe Leu Pro Pro Pro  Leu Pro Ser Gly Leu  Phe Gly Leu 
    1265                 1270                 1275             


Gly Met  Asn Gln Asp Lys Gly  Ser Arg Lys Gln Pro  Ile Glu Pro 
    1280                 1285                 1290             


Cys Arg  Pro Met Lys Pro Leu  Tyr Trp Thr Arg Ile  Gln Leu His 
    1295                 1300                 1305             


Ser Lys  Arg Asp Ser Ser Thr  Ser Leu Ile Trp Glu  Lys Ile Glu 
    1310                 1315                 1320             


Glu Pro  Ser Ile Asp Cys His  Glu Phe Glu Glu Leu  Phe Ser Lys 
    1325                 1330                 1335             


Thr Ala  Val Lys Glu Arg Lys  Lys Pro Ile Ser Asp  Thr Ile Ser 
    1340                 1345                 1350             


Lys Thr  Lys Ala Lys Gln Val  Val Lys Leu Leu Ser  Asn Lys Arg 
    1355                 1360                 1365             


Ser Gln  Ala Val Gly Ile Leu  Met Ser Ser Leu His  Leu Asp Met 
    1370                 1375                 1380             


Lys Asp  Ile Gln His Ala Val  Val Asn Leu Asp Asn  Ser Val Val 
    1385                 1390                 1395             


Asp Leu  Glu Thr Leu Gln Ala  Leu Tyr Glu Asn Arg  Ala Gln Ser 
    1400                 1405                 1410             


Asp Glu  Leu Glu Lys Ile Glu  Lys His Gly Arg Ser  Ser Lys Asp 
    1415                 1420                 1425             


Lys Glu  Asn Ala Lys Ser Leu  Asp Lys Pro Glu Gln  Phe Leu Tyr 
    1430                 1435                 1440             


Glu Leu  Ser Leu Ile Pro Asn  Phe Ser Glu Arg Val  Phe Cys Ile 
    1445                 1450                 1455             


Leu Phe  Gln Ser Thr Phe Ser  Glu Ser Ile Cys Ser  Ile Arg Arg 
    1460                 1465                 1470             


Lys Leu  Glu Leu Leu Gln Lys  Leu Cys Glu Thr Leu  Lys Asn Gly 
    1475                 1480                 1485             


Pro Gly  Val Met Gln Val Leu  Gly Leu Val Leu Ala  Phe Gly Asn 
    1490                 1495                 1500             


Tyr Met  Asn Gly Gly Asn Lys  Thr Arg Gly Gln Ala  Asp Gly Phe 
    1505                 1510                 1515             


Gly Leu  Asp Ile Leu Pro Lys  Leu Lys Asp Val Lys  Ser Ser Asp 
    1520                 1525                 1530             


Asn Ser  Arg Ser Leu Leu Ser  Tyr Ile Val Ser Tyr  Tyr Leu Arg 
    1535                 1540                 1545             


Asn Phe  Asp Glu Asp Ala Gly  Lys Glu Gln Cys Leu  Phe Pro Leu 
    1550                 1555                 1560             


Pro Glu  Pro Gln Asp Leu Phe  Gln Ala Ser Gln Met  Lys Phe Glu 
    1565                 1570                 1575             


Asp Phe  Gln Lys Asp Leu Arg  Lys Leu Lys Lys Asp  Leu Lys Ala 
    1580                 1585                 1590             


Cys Glu  Val Glu Ala Gly Lys  Val Tyr Gln Val Ser  Ser Lys Glu 
    1595                 1600                 1605             


His Met  Gln Pro Phe Lys Glu  Asn Met Glu Gln Phe  Ile Ile Gln 
    1610                 1615                 1620             


Ala Lys  Ile Asp Gln Glu Ala  Glu Glu Asn Ser Leu  Thr Glu Thr 
    1625                 1630                 1635             


His Lys  Cys Phe Leu Glu Thr  Thr Ala Tyr Phe Phe  Met Lys Pro 
    1640                 1645                 1650             


Lys Leu  Gly Glu Lys Glu Val  Ser Pro Asn Ala Phe  Phe Ser Ile 
    1655                 1660                 1665             


Trp His  Glu Phe Ser Ser Asp  Phe Lys Asp Phe Trp  Lys Lys Glu 
    1670                 1675                 1680             


Asn Lys  Leu Leu Leu Gln Glu  Arg Val Lys Glu Ala  Glu Glu Val 
    1685                 1690                 1695             


Cys Arg  Gln Lys Lys Gly Lys  Ser Leu Tyr Lys Ile  Lys Pro Arg 
    1700                 1705                 1710             


His Asp  Ser Gly Ile Lys Ala  Lys Ile Ser Met Lys  Thr 
    1715                 1720                 1725     


<210>  6
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  7
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Ala Leu Pro Phe Gln Lys Glu Leu Glu Lys Tyr Lys Asn Ile Asp 
1               5                   10                  15      


Glu Asp Glu Leu Leu Gly Lys Leu Ser Glu Glu Glu Leu Lys Gln Leu 
            20                  25                  30          


Glu Asn Val Leu Asp Asp Leu Asp Pro Glu Ser Ala Met Leu Pro Ala 
        35                  40                  45              


Gly Phe Arg Gln Lys Asp Gln Thr Gln Lys Ala Ala Thr Gly Pro Phe 
    50                  55                  60                  


Asp Arg Glu His Leu Leu Met Tyr Leu Glu Lys Glu Ala Leu Glu Gln 
65                  70                  75                  80  


Lys Asp Arg Glu Asp Phe Val Pro Phe Thr Gly Glu Lys Lys Gly Arg 
                85                  90                  95      


Val Phe Ile Pro Lys Glu Lys Pro Ile Glu Thr Arg Lys Glu Glu Lys 
            100                 105                 110         


Val Thr Leu Asp Pro Glu Leu Glu Glu Ala Leu Ala Ser Ala Ser Asp 
        115                 120                 125             


Thr Glu Leu Tyr Asp Leu Ala Ala Val Leu Gly Val His Asn Leu Leu 
    130                 135                 140                 


Asn Asn Pro Lys Phe Asp Glu Glu Thr Ala Asn Asn Lys Gly Gly Lys 
145                 150                 155                 160 


Gly Pro Val Arg Asn Val Val Lys Gly Glu Lys Val Lys Pro Val Phe 
                165                 170                 175     


Glu Glu Pro Pro Asn Pro Thr Asn Val Glu Ile Ser Leu Gln Gln Met 
            180                 185                 190         


Lys Ala Asn Asp Pro Ser Leu Gln Glu Val Asn Leu Asn Asn Ile Lys 
        195                 200                 205             


Asn Ile Pro Ile Pro Thr Leu Arg Glu Phe Ala Lys Ala Leu Glu Thr 
    210                 215                 220                 


Asn Thr His Val Lys Lys Phe Ser Leu Ala Ala Thr Arg Ser Asn Asp 
225                 230                 235                 240 


Pro Val Ala Ile Ala Phe Ala Asp Met Leu Lys Val Asn Lys Thr Leu 
                245                 250                 255     


Thr Ser Leu Asn Ile Glu Ser Asn Phe Ile Thr Gly Thr Gly Ile Leu 
            260                 265                 270         


Ala Leu Val Glu Ala Leu Lys Glu Asn Asp Thr Leu Thr Glu Ile Lys 
        275                 280                 285             


Ile Asp Asn Gln Arg Gln Gln Leu Gly Thr Ala Val Glu Met Glu Ile 
    290                 295                 300                 


Ala Gln Met Leu Glu Glu Asn Ser Arg Ile Leu Lys Phe Gly Tyr Gln 
305                 310                 315                 320 


Phe Thr Lys Gln Gly Pro Arg Thr Arg Val Ala Ala Ala Ile Thr Lys 
                325                 330                 335     


Asn Asn Asp Leu Val Arg Lys Lys Arg Val Glu Ala Asp Arg Arg 
            340                 345                 350     


<210>  8
<211>  2639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Gly Ala  Gly Ile Gly 
    1640                 1645                 1650             


Pro Thr  Ile Gln Ile Gly Glu  Glu Thr Val Ile Thr  Val Asp Thr 
    1655                 1660                 1665             


Lys Ala  Ala Gly Lys Gly Lys  Val Thr Cys Thr Val  Cys Thr Pro 
    1670                 1675                 1680             


Asp Gly  Ser Glu Val Asp Val  Asp Val Val Glu Asn  Glu Asp Gly 
    1685                 1690                 1695             


Thr Phe  Asp Ile Phe Tyr Thr  Ala Pro Gln Pro Gly  Lys Tyr Val 
    1700                 1705                 1710             


Ile Cys  Val Arg Phe Gly Gly  Glu His Val Pro Asn  Ser Pro Phe 
    1715                 1720                 1725             


Gln Val  Thr Ala Leu Ala Gly  Asp Gln Pro Ser Val  Gln Pro Pro 
    1730                 1735                 1740             


Leu Arg  Ser Gln Gln Leu Ala  Pro Gln Tyr Thr Tyr  Ala Gln Gly 
    1745                 1750                 1755             


Gly Gln  Gln Thr Trp Ala Pro  Glu Arg Pro Leu Val  Gly Val Asn 
    1760                 1765                 1770             


Gly Leu  Asp Val Thr Ser Leu  Arg Pro Phe Asp Leu  Val Ile Pro 
    1775                 1780                 1785             


Phe Thr  Ile Lys Lys Gly Glu  Ile Thr Gly Glu Val  Arg Met Pro 
    1790                 1795                 1800             


Ser Gly  Lys Val Ala Gln Pro  Thr Ile Thr Asp Asn  Lys Asp Gly 
    1805                 1810                 1815             


Thr Val  Thr Val Arg Tyr Ala  Pro Ser Glu Ala Gly  Leu His Glu 
    1820                 1825                 1830             


Met Asp  Ile Arg Tyr Asp Asn  Met His Ile Pro Gly  Ser Pro Leu 
    1835                 1840                 1845             


Gln Phe  Tyr Val Asp Tyr Val  Asn Cys Gly His Val  Thr Ala Tyr 
    1850                 1855                 1860             


Gly Pro  Gly Leu Thr His Gly  Val Val Asn Lys Pro  Ala Thr Phe 
    1865                 1870                 1875             


Thr Val  Asn Thr Lys Asp Ala  Gly Glu Gly Gly Leu  Ser Leu Ala 
    1880                 1885                 1890             


Ile Glu  Gly Pro Ser Lys Ala  Glu Ile Ser Cys Thr  Asp Asn Gln 
    1895                 1900                 1905             


Asp Gly  Thr Cys Ser Val Ser  Tyr Leu Pro Val Leu  Pro Gly Asp 
    1910                 1915                 1920             


Tyr Ser  Ile Leu Val Lys Tyr  Asn Glu Gln His Val  Pro Gly Ser 
    1925                 1930                 1935             


Pro Phe  Thr Ala Arg Val Thr  Gly Asp Asp Ser Met  Arg Met Ser 
    1940                 1945                 1950             


His Leu  Lys Val Gly Ser Ala  Ala Asp Ile Pro Ile  Asn Ile Ser 
    1955                 1960                 1965             


Glu Thr  Asp Leu Ser Leu Leu  Thr Ala Thr Val Val  Pro Pro Ser 
    1970                 1975                 1980             


Gly Arg  Glu Glu Pro Cys Leu  Leu Lys Arg Leu Arg  Asn Gly His 
    1985                 1990                 1995             


Val Gly  Ile Ser Phe Val Pro  Lys Glu Thr Gly Glu  His Leu Val 
    2000                 2005                 2010             


His Val  Lys Lys Asn Gly Gln  His Val Ala Ser Ser  Pro Ile Pro 
    2015                 2020                 2025             


Val Val  Ile Ser Gln Ser Glu  Ile Gly Asp Ala Ser  Arg Val Arg 
    2030                 2035                 2040             


Val Ser  Gly Gln Gly Leu His  Glu Gly His Thr Phe  Glu Pro Ala 
    2045                 2050                 2055             


Glu Phe  Ile Ile Asp Thr Arg  Asp Ala Gly Tyr Gly  Gly Leu Ser 
    2060                 2065                 2070             


Leu Ser  Ile Glu Gly Pro Ser  Lys Val Asp Ile Asn  Thr Glu Asp 
    2075                 2080                 2085             


Leu Glu  Asp Gly Thr Cys Arg  Val Thr Tyr Cys Pro  Thr Glu Pro 
    2090                 2095                 2100             


Gly Asn  Tyr Ile Ile Asn Ile  Lys Phe Ala Asp Gln  His Val Pro 
    2105                 2110                 2115             


Gly Ser  Pro Phe Ser Val Lys  Val Thr Gly Glu Gly  Arg Val Lys 
    2120                 2125                 2130             


Glu Ser  Ile Thr Arg Arg Arg  Arg Ala Pro Ser Val  Ala Asn Val 
    2135                 2140                 2145             


Gly Ser  His Cys Asp Leu Ser  Leu Lys Ile Pro Glu  Ile Ser Ile 
    2150                 2155                 2160             


Gln Asp  Met Thr Ala Gln Val  Thr Ser Pro Ser Gly  Lys Thr His 
    2165                 2170                 2175             


Glu Ala  Glu Ile Val Glu Gly  Glu Asn His Thr Tyr  Cys Ile Arg 
    2180                 2185                 2190             


Phe Val  Pro Ala Glu Met Gly  Thr His Thr Val Ser  Val Lys Tyr 
    2195                 2200                 2205             


Lys Gly  Gln His Val Pro Gly  Ser Pro Phe Gln Phe  Thr Val Gly 
    2210                 2215                 2220             


Pro Leu  Gly Glu Gly Gly Ala  His Lys Val Arg Ala  Gly Gly Pro 
    2225                 2230                 2235             


Gly Leu  Glu Arg Ala Glu Ala  Gly Val Pro Ala Glu  Phe Ser Ile 
    2240                 2245                 2250             


Trp Thr  Arg Glu Ala Gly Ala  Gly Gly Leu Ala Ile  Ala Val Glu 
    2255                 2260                 2265             


Gly Pro  Ser Lys Ala Glu Ile  Ser Phe Glu Asp Arg  Lys Asp Gly 
    2270                 2275                 2280             


Ser Cys  Gly Val Ala Tyr Val  Val Gln Glu Pro Gly  Asp Tyr Glu 
    2285                 2290                 2295             


Val Ser  Val Lys Phe Asn Glu  Glu His Ile Pro Asp  Ser Pro Phe 
    2300                 2305                 2310             


Val Val  Pro Val Ala Ser Pro  Ser Gly Asp Ala Arg  Arg Leu Thr 
    2315                 2320                 2325             


Val Ser  Ser Leu Gln Glu Ser  Gly Leu Lys Val Asn  Gln Pro Ala 
    2330                 2335                 2340             


Ser Phe  Ala Val Ser Leu Asn  Gly Ala Lys Gly Ala  Ile Asp Ala 
    2345                 2350                 2355             


Lys Val  His Ser Pro Ser Gly  Ala Leu Glu Glu Cys  Tyr Val Thr 
    2360                 2365                 2370             


Glu Ile  Asp Gln Asp Lys Tyr  Ala Val Arg Phe Ile  Pro Arg Glu 
    2375                 2380                 2385             


Asn Gly  Val Tyr Leu Ile Asp  Val Lys Phe Asn Gly  Thr His Ile 
    2390                 2395                 2400             


Pro Gly  Ser Pro Phe Lys Ile  Arg Val Gly Glu Pro  Gly His Gly 
    2405                 2410                 2415             


Gly Asp  Pro Gly Leu Val Ser  Ala Tyr Gly Ala Gly  Leu Glu Gly 
    2420                 2425                 2430             


Gly Val  Thr Gly Asn Pro Ala  Glu Phe Val Val Asn  Thr Ser Asn 
    2435                 2440                 2445             


Ala Gly  Ala Gly Ala Leu Ser  Val Thr Ile Asp Gly  Pro Ser Lys 
    2450                 2455                 2460             


Val Lys  Met Asp Cys Gln Glu  Cys Pro Glu Gly Tyr  Arg Val Thr 
    2465                 2470                 2475             


Tyr Thr  Pro Met Ala Pro Gly  Ser Tyr Leu Ile Ser  Ile Lys Tyr 
    2480                 2485                 2490             


Gly Gly  Pro Tyr His Ile Gly  Gly Ser Pro Phe Lys  Ala Lys Val 
    2495                 2500                 2505             


Thr Gly  Pro Arg Leu Val Ser  Asn His Ser Leu His  Glu Thr Ser 
    2510                 2515                 2520             


Ser Val  Phe Val Asp Ser Leu  Thr Lys Ala Thr Cys  Ala Pro Gln 
    2525                 2530                 2535             


His Gly  Ala Pro Gly Pro Gly  Pro Ala Asp Ala Ser  Lys Val Val 
    2540                 2545                 2550             


Ala Lys  Gly Leu Gly Leu Ser  Lys Ala Tyr Val Gly  Gln Lys Ser 
    2555                 2560                 2565             


Ser Phe  Thr Val Asp Cys Ser  Lys Ala Gly Asn Asn  Met Leu Leu 
    2570                 2575                 2580             


Val Gly  Val His Gly Pro Arg  Thr Pro Cys Glu Glu  Ile Leu Val 
    2585                 2590                 2595             


Lys His  Val Gly Ser Arg Leu  Tyr Ser Val Ser Tyr  Leu Leu Lys 
    2600                 2605                 2610             


Asp Lys  Gly Glu Tyr Thr Leu  Val Val Lys Trp Gly  Asp Glu His 
    2615                 2620                 2625             


Ile Pro  Gly Ser Pro Tyr Arg  Val Val Val Pro 
    2630                 2635                 


<210>  9
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Glu Asn Ser Thr Thr Thr Ile Ser Arg Glu Glu Leu Glu Glu Leu 
1               5                   10                  15      


Gln Glu Ala Phe Asn Lys Ile Asp Ile Asp Asn Ser Gly Tyr Val Ser 
            20                  25                  30          


Asp Tyr Glu Leu Gln Asp Leu Phe Lys Glu Ala Ser Leu Pro Leu Pro 
        35                  40                  45              


Gly Tyr Lys Val Arg Glu Ile Val Glu Lys Ile Leu Ser Val Ala Asp 
    50                  55                  60                  


Ser Asn Lys Asp Gly Lys Ile Ser Phe Glu Glu Phe Val Ser Leu Met 
65                  70                  75                  80  


Gln Glu Leu Lys Ser Lys Asp Ile Ser Lys Thr Phe Arg Lys Ile Ile 
                85                  90                  95      


Asn Lys Arg Glu Gly Ile Thr Ala Ile Gly Gly Thr Ser Thr Ile Ser 
            100                 105                 110         


Ser Glu Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Val Ala Phe 
        115                 120                 125             


Val Asn Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Lys His 
    130                 135                 140                 


Leu Ile Pro Met Asn Pro Asn Asp Asp Ser Leu Phe Lys Ser Leu Ala 
145                 150                 155                 160 


Asp Gly Ile Leu Leu Cys Lys Met Ile Asn Leu Ser Glu Pro Asp Thr 
                165                 170                 175     


Ile Asp Glu Arg Ala Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile 
            180                 185                 190         


Ser Glu Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys 
        195                 200                 205             


Thr Val Val Asn Ile Gly Ala Ser Asp Leu Lys Glu Gly Lys Pro His 
    210                 215                 220                 


Leu Val Leu Gly Leu Leu Trp Gln Ile Ile Lys Val Gly Leu Phe Ala 
225                 230                 235                 240 


Asp Ile Glu Ile Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Asn Glu 
                245                 250                 255     


Gly Glu Glu Leu Glu Glu Leu Met Lys Leu Ser Pro Glu Glu Leu Leu 
            260                 265                 270         


Leu Arg Trp Val Asn Tyr His Leu Thr Asn Ala Gly Trp His Thr Ile 
        275                 280                 285             


Ser Asn Phe Ser Gln Asp Ile Lys Asp Ser Arg Ala Tyr Phe His Leu 
    290                 295                 300                 


Leu Asn Gln Ile Ala Pro Lys Gly Gly Glu Asp Gly Pro Ala Ile Ala 
305                 310                 315                 320 


Ile Asp Leu Ser Gly Ile Asn Glu Thr Asn Asp Leu Lys Arg Ala Gly 
                325                 330                 335     


Leu Met Leu Gln Glu Ala Asp Lys Leu Gly Cys Lys Gln Phe Val Thr 
            340                 345                 350         


Pro Ala Asp Val Val Ser Gly Asn Pro Lys Leu Asn Leu Ala Phe Val 
        355                 360                 365             


Ala Asn Leu Phe Asn Thr Tyr Pro Cys Leu His Lys Pro Asn Asn Asn 
    370                 375                 380                 


Asp Ile Asp Met Asn Leu Leu Glu Gly Glu Ser Lys Glu Glu Arg Thr 
385                 390                 395                 400 


Phe Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Tyr Ile Asn His 
                405                 410                 415     


Leu Tyr Ser Asp Leu Ala Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu 
            420                 425                 430         


Met Ile Arg Val Pro Val Asn Trp Ser His Val Asn Lys Pro Pro Tyr 
        435                 440                 445             


Pro Ala Leu Gly Gly Asn Met Lys Lys Ile Glu Asn Cys Asn Tyr Ala 
    450                 455                 460                 


Val Glu Leu Gly Lys Asn Lys Ala Lys Phe Ser Leu Val Gly Ile Ala 
465                 470                 475                 480 


Gly Gln Asp Leu Asn Glu Gly Asn Ser Thr Leu Thr Leu Ala Leu Val 
                485                 490                 495     


Trp Gln Leu Met Arg Arg Tyr Thr Leu Asn Val Leu Ser Asp Leu Gly 
            500                 505                 510         


Glu Gly Glu Lys Val Asn Asp Glu Ile Ile Ile Lys Trp Val Asn Gln 
        515                 520                 525             


Thr Leu Lys Ser Ala Asn Lys Lys Thr Ser Ile Ser Ser Phe Lys Asp 
    530                 535                 540                 


Lys Ser Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile 
545                 550                 555                 560 


Ala Pro Asn Ala Val Arg Gln Glu Met Ile Arg Arg Glu Asn Leu Ser 
                565                 570                 575     


Asp Glu Asp Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Val Ala Arg 
            580                 585                 590         


Lys Ile Gly Ala Arg Ile Tyr Ala Leu Pro Asp Asp Leu Val Glu Val 
        595                 600                 605             


Lys Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly 
    610                 615                 620                 


Leu Asn Arg Ile Lys 
625                 


<210>  10
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ala Gly Trp Asn Ala Tyr Ile Asp Asn Leu Met Ala Asp Gly Thr 
1               5                   10                  15      


Cys Gln Asp Ala Ala Ile Val Gly Tyr Lys Asp Ser Pro Ser Val Trp 
            20                  25                  30          


Ala Ala Val Pro Gly Lys Thr Phe Val Asn Ile Thr Pro Ala Glu Val 
        35                  40                  45              


Gly Val Leu Val Gly Lys Asp Arg Ser Ser Phe Tyr Val Asn Gly Leu 
    50                  55                  60                  


Thr Leu Gly Gly Gln Lys Cys Ser Val Ile Arg Asp Ser Leu Leu Gln 
65                  70                  75                  80  


Asp Gly Glu Phe Ser Met Asp Leu Arg Thr Lys Ser Thr Gly Gly Ala 
                85                  90                  95      


Pro Thr Phe Asn Val Thr Val Thr Lys Thr Asp Lys Thr Leu Val Leu 
            100                 105                 110         


Leu Met Gly Lys Glu Gly Val His Gly Gly Leu Ile Asn Lys Lys Cys 
        115                 120                 125             


Tyr Glu Met Ala Ser His Leu Arg Arg Ser Gln Tyr 
    130                 135                 140 


<210>  11
<211>  876
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
225                 230                 235                 240 


Gly Leu Arg Ser Arg Met Ala Ser Leu Ser Ala Val Val Val Ala Pro 
                245                 250                 255     


Ser Val Ser Ser Ser Ala Ala Val Pro Pro Ala Pro Pro Leu Pro Gly 
            260                 265                 270         


Asp Ser Gly Thr Val Ile Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
        275                 280                 285             


Gly Gly Val Val Pro Pro Ser Pro Pro Leu Pro Pro Gly Thr Cys Ile 
    290                 295                 300                 


Pro Pro Pro Pro Pro Leu Pro Gly Gly Ala Cys Ile Pro Pro Pro Pro 
305                 310                 315                 320 


Gln Leu Pro Gly Ser Ala Ala Ile Pro Pro Pro Pro Pro Leu Pro Gly 
                325                 330                 335     


Val Ala Ser Ile Pro Pro Pro Pro Pro Leu Pro Gly Ala Thr Ala Ile 
            340                 345                 350         


Pro Pro Pro Pro Pro Leu Pro Gly Ala Thr Ala Ile Pro Pro Pro Pro 
        355                 360                 365             


Pro Leu Pro Gly Gly Thr Gly Ile Pro Pro Pro Pro Pro Pro Leu Pro 
    370                 375                 380                 


Gly Ser Val Gly Val Pro Pro Pro Pro Pro Leu Pro Gly Gly Pro Gly 
385                 390                 395                 400 


Leu Pro Pro Pro Pro Pro Pro Phe Pro Gly Ala Pro Gly Ile Pro Pro 
                405                 410                 415     


Pro Pro Pro Gly Met Gly Val Pro Pro Pro Pro Pro Phe Gly Phe Gly 
            420                 425                 430         


Val Pro Ala Ala Pro Val Leu Pro Phe Gly Leu Thr Pro Lys Lys Val 
        435                 440                 445             


Tyr Lys Pro Glu Val Gln Leu Arg Arg Pro Asn Trp Ser Lys Phe Val 
    450                 455                 460                 


Ala Glu Asp Leu Ser Gln Asp Cys Phe Trp Thr Lys Val Lys Glu Asp 
465                 470                 475                 480 


Arg Phe Glu Asn Asn Glu Leu Phe Ala Lys Leu Thr Leu Ala Phe Ser 
                485                 490                 495     


Ala Gln Thr Lys Thr Ser Lys Ala Lys Lys Asp Gln Glu Gly Gly Glu 
            500                 505                 510         


Glu Lys Lys Ser Val Gln Lys Lys Lys Val Lys Glu Leu Lys Val Leu 
        515                 520                 525             


Asp Ser Lys Thr Ala Gln Asn Leu Ser Ile Phe Leu Gly Ser Phe Arg 
    530                 535                 540                 


Met Pro Tyr Gln Glu Ile Lys Asn Val Ile Leu Glu Val Asn Glu Ala 
545                 550                 555                 560 


Val Leu Thr Glu Ser Met Ile Gln Asn Leu Ile Lys Gln Met Pro Glu 
                565                 570                 575     


Pro Glu Gln Leu Lys Met Leu Ser Glu Leu Lys Glu Glu Tyr Asp Asp 
            580                 585                 590         


Leu Ala Glu Ser Glu Gln Phe Gly Val Val Met Gly Thr Val Pro Arg 
        595                 600                 605             


Leu Arg Pro Arg Leu Asn Ala Ile Leu Phe Lys Leu Gln Phe Ser Glu 
    610                 615                 620                 


Gln Val Glu Asn Ile Lys Pro Glu Ile Val Ser Val Thr Ala Ala Cys 
625                 630                 635                 640 


Glu Glu Leu Arg Lys Ser Glu Asn Phe Ser Ser Leu Leu Glu Leu Thr 
                645                 650                 655     


Leu Leu Val Gly Asn Tyr Met Asn Ala Gly Ser Arg Asn Ala Gly Ala 
            660                 665                 670         


Phe Gly Phe Asn Ile Ser Phe Leu Cys Lys Leu Arg Asp Thr Lys Ser 
        675                 680                 685             


Ala Asp Gln Lys Met Thr Leu Leu His Phe Leu Ala Glu Leu Cys Glu 
    690                 695                 700                 


Asn Asp His Pro Glu Val Leu Lys Phe Pro Asp Glu Leu Ala His Val 
705                 710                 715                 720 


Glu Lys Ala Ser Arg Val Ser Ala Glu Asn Leu Gln Lys Ser Leu Asp 
                725                 730                 735     


Gln Met Lys Lys Gln Ile Ala Asp Val Glu Arg Asp Val Gln Asn Phe 
            740                 745                 750         


Pro Ala Ala Thr Asp Glu Lys Asp Lys Phe Val Glu Lys Met Thr Ser 
        755                 760                 765             


Phe Val Lys Asp Ala Gln Glu Gln Tyr Asn Lys Leu Arg Met Met His 
    770                 775                 780                 


Ser Asn Met Glu Thr Leu Tyr Lys Glu Leu Gly Asp Tyr Phe Val Phe 
785                 790                 795                 800 


Asp Pro Lys Lys Leu Ser Val Glu Glu Phe Phe Met Asp Leu His Asn 
                805                 810                 815     


Phe Arg Asn Met Phe Leu Gln Ala Val Lys Glu Asn Gln Lys Arg Arg 
            820                 825                 830         


Glu Thr Glu Glu Lys Met Arg Arg Ala Lys Leu Ala Lys Glu Lys Ala 
        835                 840                 845             


Glu Lys Glu Arg Leu Glu Lys Gln Gln Lys Arg Glu Gln Leu Ile Asp 
    850                 855                 860                 


Met Asn Ala Glu Gly Asp Glu Thr Gly Val Met Asp 
865                 870                 875     


<210>  12
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  repeat_unit
<222>  (1)..(6)
<223>  region may repeat 80 or more times

<400>  12
ggggcc                                                                   6


<210>  13
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
ccccggcccc ggcccc                                                       16


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gcttaatgcc agaccgggag ttgga                                             25


<210>  15
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
tcatcttcat ccaggtcata taaatt                                            26


<210>  16
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
ggtggctctg gaggcggatc cgccgggtgg aacgcctaca tcg                         43


<210>  17
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
ttatctagat ccggtggatc ctcagtactg ggaacgccga agg                         43


<210>  18
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gagactcgag ccatggcttc tctctctgct g                                      31


<210>  19
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gagaggatcc ttagcttgca cggccaac                                          28


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gggggaccta gagagaagaa                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
cgtagccgaa cgaactcatg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
cgcttgtagg aggtcgaaaa                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
agtagctgga gtacgcggag                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
acggacagcg aggaggagac                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
atcaaagagc cagagctgga                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
ctcagatcga gattctccag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
ggatagactt gaggtcgttg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
atgaagctgg cgaagcgatc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gaaggctcag agtgtttctg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
ttctcgttag tggcgtcttc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
tcagcacttc ttcctcatag                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
aaagctatct cgtccatcag                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
tctgagcata ctggatctga                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
ttggaggaca cgtccatctc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ttgaaccact cttcggcgtt                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
tctcggttag cacggtgaag                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
ttcgatctcc agggtcttag                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ctaatgtctg cattctgctt                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
tctccagttt gttgattgtg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
catcttgaca ttgaggaggt                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
ctgcaatctc gatgtccaag                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
ccttccaaga gttttctgta                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
tgaaactgag cctggtctct                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
aagacctgcg agctctgaga                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
aagccactgt aagcagaacg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gagcgagcag acatcaagta                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
cagctttcgt agcctcaatg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
ttgggaatag ggctcaatct                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
attggggaga acttttcctg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
tgtataggat ctggaactca                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
cctaagtcat ctcagaatta                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
tagcacaaca ttgaaagtcc                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
gatactctgc gtaaggagga                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
aaagccactc tgcaagcaaa                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
ataagcatgg accatgcaca                                                   20


