                         SEQUENCE LISTING

<110>  Purinomia, Inc
       Wu, Yan
 
<120>  Methods and Compositions for Promoting and Potentiating T-cell 
       Mediated Immune Responses Through ADCC Targeting of CD39 
       Expressing Cells

<130>  Purinomia

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from human variable chain library


<220>
<221>  CDS
<222>  (1)..(357)

<400>  1
gag gtg caa ctg gtg gag tct ggg gga ggt gtg gta agg cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gct atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt ata tca tat gat gta agc aat aaa tac tac gca gac tcc gtg        192
Ala Val Ile Ser Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gct gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tct tac tac tac tac tac ggt atg gac gtc tgg ggc caa ggg        336
Ala Arg Ser Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tca                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Derived from human variable chain library


<220>
<221>  CDS
<222>  (1)..(321)

<400>  3
gat gtt gtg atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agg tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr           
            20                  25                  30                    

tta gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc aac agg gcc act ggc atc cca gtc agg ttc agt ggc        192
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag cca        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtg tat tac tgt cag cag ttt ggt agg tca cct cgg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro Arg           
                85                  90                  95                

acg ttc ggc caa ggg aca cga ctg gag att aaa                            321
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys                               
            100                 105                                       


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(357)

<400>  5
cag tca gtg aag gag gcc ggg ggt cgc ctg gta acg cct gga gga tcc         48
Gln Ser Val Lys Glu Ala Gly Gly Arg Leu Val Thr Pro Gly Gly Ser           
1               5                   10                  15                

ctg aca ctc acc tgc aca gtc tct gga ttc tcc ctc agt gcg tat gga         96
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr Gly           
            20                  25                  30                    

ata agt tgg gtc cgc cag gct cca ggg aag gga ctg gaa tgg atc gga        144
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly           
        35                  40                  45                        

atc att tat agt agt ggt agg act tac tac gcg aac tgg gcg aaa ggc        192
Ile Ile Tyr Ser Ser Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys Gly           
    50                  55                  60                            

cga ttc acc atc tcc aaa acc tcg tcg acc acg gtg gat ctg aaa atg        240
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met           
65                  70                  75                  80            

acc agt ctg aca acc gag gac acg gcc gcc tat ttc tgt gcc aga tca        288
Thr Ser Leu Thr Thr Glu Asp Thr Ala Ala Tyr Phe Cys Ala Arg Ser           
                85                  90                  95                

cgg gct ggt att agt agt ggt gat ggt ttt gat tcc tgg ggc cca ggc        336
Arg Ala Gly Ile Ser Ser Gly Asp Gly Phe Asp Ser Trp Gly Pro Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tca                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  6
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Gln Ser Val Lys Glu Ala Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr Gly 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ser Ser Gly Arg Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Ala Tyr Phe Cys Ala Arg Ser 
                85                  90                  95      


Arg Ala Gly Ile Ser Ser Gly Asp Gly Phe Asp Ser Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(339)

<400>  7
gcc aga tgt gcc ctt gtg atg acc cag act cca tcc tcc gtg tct gca         48
Ala Arg Cys Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala           
1               5                   10                  15                

gct gtg gga ggc aca gtc acc atc aat tgc cag gcc agt cag aac att         96
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile           
            20                  25                  30                    

tac agc aat tta gcc tgg tat cag cag aaa cca ggg cag cgt ccc cag        144
Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Gln           
        35                  40                  45                        

ctc ctg atc tac agg gca tcc act ctg gca tct ggg gtc cca tcg cgg        192
Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg           
    50                  55                  60                            

ttc aaa ggc agt gca tct ggg aca gaa tac act ctc acc atc agc ggt        240
Phe Lys Gly Ser Ala Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly           
65                  70                  75                  80            

gtg cag tgt gac gat gct gcc act tac tat tgt caa cag ggt ttt gat        288
Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Asp           
                85                  90                  95                

agt agt aac att gat aat act ttc ggc gga ggg acc gag gtg gtg gtc        336
Ser Ser Asn Ile Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val           
            100                 105                 110                   

aca                                                                    339
Thr                                                                       
                                                                          


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Ala Arg Cys Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala 
1               5                   10                  15      


Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile 
            20                  25                  30          


Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Gln 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Lys Gly Ser Ala Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Asp 
                85                  90                  95      


Ser Ser Asn Ile Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Thr 
    


<210>  9
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(345)

<400>  9
cag tcg gtg gag gag tcc ggg ggt cgc ctg gtc acg cct ggg aca cac         48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr His           
1               5                   10                  15                

ctg aca ctc acc tgc aca gtc tct gga ttc tcc ctc agt aag agt ata         96
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Lys Ser Ile           
            20                  25                  30                    

ata agt tgg gtc cgc cag gct cca ggg aag ggg ctg gaa tac atc gga        144
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly           
        35                  40                  45                        

atc att ggt agt agt ggt agc aca tac tac gcg aac tgg gcg aaa ggc        192
Ile Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly           
    50                  55                  60                            

cga ttc acc atc tcc aaa acc tcg tcg acc acg gtg gat ctg aga atg        240
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Arg Met           
65                  70                  75                  80            

acc agt ctg aca ccc gag gac acg gcc acc tat ttc tgt gcc aga gga        288
Thr Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly           
                85                  90                  95                

ctt ctt tat tct ggt aat aaa tcg tgg ggc ccg ggc acc ctg gtc acc        336
Leu Leu Tyr Ser Gly Asn Lys Ser Trp Gly Pro Gly Thr Leu Val Thr           
            100                 105                 110                   

gtc tcc tca                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  10
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr His 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Lys Ser Ile 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Arg Met 
65                  70                  75                  80  


Thr Ser Leu Thr Pro Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Leu Leu Tyr Ser Gly Asn Lys Ser Trp Gly Pro Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  11
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(339)

<400>  11
gcc aca ttt gcc att gat atg acc cag act cca tcc tcc gtg tct gca         48
Ala Thr Phe Ala Ile Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala           
1               5                   10                  15                

gct gtg gga ggc aca gtc acc atc aac tgc cag tcc agt cag agt gtt         96
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val           
            20                  25                  30                    

tta ctg aac aac caa tta tcc tgg ttt cag cag aaa cca ggg cag cct        144
Leu Leu Asn Asn Gln Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro           
        35                  40                  45                        

ccc aag ctc ctg atc tat gat gca tcc act ctg gaa tct ggg gtc cca        192
Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro           
    50                  55                  60                            

tct cgg ttc aca ggc agt gga tct ggg aca cag ttc act ctc acc atc        240
Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile           
65                  70                  75                  80            

agc gac ctg gag tgt gac gat gct gcc act tac tat tgt tta ggc ggt        288
Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly           
                85                  90                  95                

tat agt ggg aac ctt tat gct ttc ggc gga ggg acc gag gtg cta gtc        336
Tyr Ser Gly Asn Leu Tyr Ala Phe Gly Gly Gly Thr Glu Val Leu Val           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Ala Thr Phe Ala Ile Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala 
1               5                   10                  15      


Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val 
            20                  25                  30          


Leu Leu Asn Asn Gln Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly 
                85                  90                  95      


Tyr Ser Gly Asn Leu Tyr Ala Phe Gly Gly Gly Thr Glu Val Leu Val 
            100                 105                 110         


Lys 
    


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(351)

<400>  13
cag tcg gtg gag gag tcc ggg ggt cgc ctg gtc acg cct ggg aca ccc         48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro           
1               5                   10                  15                

ctg aca ctc acc tgc aca gtc tct gga ttc tcc ctc agt agc tat gca         96
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala           
            20                  25                  30                    

ata agt tgg gtc cgc cag gct cca ggg aag ggg ctc gaa tat atc gcg        144
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Ala           
        35                  40                  45                        

atc att aat agt tat ggt acc aca tac tac gcg agc tgg gcg aaa ggc        192
Ile Ile Asn Ser Tyr Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly           
    50                  55                  60                            

cga gtc acc atc tcc aaa acc tcg agc acg gtg gat ctg aaa atc tcc        240
Arg Val Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Ile Ser           
65                  70                  75                  80            

agt ccg aca acc gag gac acg gcc acc tat ttc tgt gcc aga ggc gat        288
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp           
                85                  90                  95                

agt tat ggt agt ggt gtt ggt ttg ggc ttg tgg ggc cca ggc acc ctg        336
Ser Tyr Gly Ser Gly Val Gly Leu Gly Leu Trp Gly Pro Gly Thr Leu           
            100                 105                 110                   

gtc acc gtc tcc tca                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Ala 
        35                  40                  45              


Ile Ile Asn Ser Tyr Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Val Thr Ile Ser Lys Thr Ser Ser Thr Val Asp Leu Lys Ile Ser 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp 
                85                  90                  95      


Ser Tyr Gly Ser Gly Val Gly Leu Gly Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(339)

<400>  15
gcc aga tgt gcc tat gat atg acc cag act cca gcc tct gtg gag gta         48
Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val           
1               5                   10                  15                

gct gtg gga ggc aca gtc acc atc aag tgc cag gcc agt cag aac att         96
Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile           
            20                  25                  30                    

tac agc aat tta gcc tgg tat cag cag aaa cca ggg cag cgt ccc aag        144
Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys           
        35                  40                  45                        

ctc ctg atc tac agg gca tcc agt ctg gca tct ggg gtc ccg tcg cgg        192
Leu Leu Ile Tyr Arg Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg           
    50                  55                  60                            

ttc agt ggc agt gga tct ggg aca gag ttc act ctc acc atc agc ggt        240
Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly           
65                  70                  75                  80            

gtg cag tgt gac gat gct gcc act tac tac tgt caa cag ggt ttt agt        288
Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser           
                85                  90                  95                

agt aat aat gtt gat aat act ttc ggc gga ggg acc gag gtg gtg gtc        336
Ser Asn Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  16
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val 
1               5                   10                  15      


Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile 
            20                  25                  30          


Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser 
                85                  90                  95      


Ser Asn Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  17
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(357)

<400>  17
cag tcg gtg gag gag tcc ggg ggt cgc ctg gtc acg cct ggg aca ccc         48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro           
1               5                   10                  15                

ctg aca ctc acc tgc acc gtc tcc gga ttc tcc ctc agt agc tat gca         96
Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala           
            20                  25                  30                    

atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gaa tac atc gga        144
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly           
        35                  40                  45                        

atc att agt agt agt ggt agc aca tac tac gcg agc tgg gcg aaa ggc        192
Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly           
    50                  55                  60                            

cga ttc acc atc tcc aaa acc tcg acc acg gtg gat ctg aaa atc tcc        240
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ser           
65                  70                  75                  80            

agt ccg aca acc gag gac acg gcc acc tat ttc tgt gcc aga gat cgt        288
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg           
                85                  90                  95                

gtt att tat agt att ggt ccg tat tat ttt aat ttg tgg ggc cca ggc        336
Val Ile Tyr Ser Ile Gly Pro Tyr Tyr Phe Asn Leu Trp Gly Pro Gly           
            100                 105                 110                   

acc ctg gtc acc gtc tcc tca                                            357
Thr Leu Val Thr Val Ser Ser                                               
        115                                                               


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ser 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Arg 
                85                  90                  95      


Val Ile Tyr Ser Ile Gly Pro Tyr Tyr Phe Asn Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(339)

<400>  19
gcc aga tgt gcc tat gat atg acc cag act cca tcc tcc gtg tct gca         48
Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala           
1               5                   10                  15                

act gtg gga ggc aca gtc acc atc aat tgc cag gcc agt gag atc att         96
Thr Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ile Ile           
            20                  25                  30                    

tat agc aat tta gcc tgg tat cag cag aaa cca ggg cag cct ccc aag        144
Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys           
        35                  40                  45                        

ctc ctg atc tat ggc gca tcc act ctg gca tct ggg gtc cca tcg cgg        192
Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg           
    50                  55                  60                            

ttc aaa ggc agt gga tct ggg aca gag tac act ctc acc atc agc gac        240
Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp           
65                  70                  75                  80            

ctg cag tgt gac gat gct gcc act tac tac tgt caa cag agt ttt agt        288
Leu Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser           
                85                  90                  95                

agt aat aat gtt ggg aat att ttc ggc gga ggg acc gag gtg gtg gtc        336
Ser Asn Asn Val Gly Asn Ile Phe Gly Gly Gly Thr Glu Val Val Val           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala 
1               5                   10                  15      


Thr Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Ile Ile 
            20                  25                  30          


Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp 
65                  70                  75                  80  


Leu Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser 
                85                  90                  95      


Ser Asn Asn Val Gly Asn Ile Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  21
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(351)

<400>  21
cag tcg gtg gag gag tcc ggg ggt cgc ctg gtc acg cct ggg aca ccc         48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro           
1               5                   10                  15                

ctg aca ctc acc tgc aca gcc tct gga ttc tcc ctc agt acc cat gca         96
Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Thr His Ala           
            20                  25                  30                    

ata aac tgg gtc cgc cag gct cca ggg aag ggg ctg gaa tgg atc ggg        144
Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly           
        35                  40                  45                        

atc act tat gct agt ggt agg aca tat tac gcg agc tgg gcg aaa ggc        192
Ile Thr Tyr Ala Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly           
    50                  55                  60                            

cga ttc acc atc tcc aaa acc tcg acc acg gtg gat ctg aaa atc acc        240
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr           
65                  70                  75                  80            

agt ccg aca acc gag gac acg gcc acc tat ttc tgt gcc aga aat ggg        288
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asn Gly           
                85                  90                  95                

gct gat gaa aca ttt tac tac ttt gac ttg tgg ggc cca ggc acc ctg        336
Ala Asp Glu Thr Phe Tyr Tyr Phe Asp Leu Trp Gly Pro Gly Thr Leu           
            100                 105                 110                   

gtc acc gtc tcc tca                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Thr His Ala 
            20                  25                  30          


Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Thr Tyr Ala Ser Gly Arg Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asn Gly 
                85                  90                  95      


Ala Asp Glu Thr Phe Tyr Tyr Phe Asp Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(339)

<400>  23
gcc aga tgt gcc tat gat atg acc cag act cca gcc tcc gtg gag gca         48
Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Ala           
1               5                   10                  15                

gct gtg gga ggc aca gtc acc atc aag tgc cag gcc agt cag aat att         96
Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile           
            20                  25                  30                    

aat act tgg tta tcc tgg tat cag cag aag gca ggg cag cct ccc aag        144
Asn Thr Trp Leu Ser Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys           
        35                  40                  45                        

ctc ctg atc tac agg gca tcc act ctg gca tct ggg gtc tca tcg cgg        192
Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg           
    50                  55                  60                            

ttc aaa ggc agt gga tct ggg aca cag ttc act ctc acc atc agc ggc        240
Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly           
65                  70                  75                  80            

gtg gag tgt gcc gat gct gcc act tac tac tgt caa caa tat gat gct        288
Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala           
                85                  90                  95                

agt att aat att gat aat gct ttc ggc gga ggg acc gag gtg gtg gtc        336
Ser Ile Asn Ile Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Ala 
1               5                   10                  15      


Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile 
            20                  25                  30          


Asn Thr Trp Leu Ser Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg 
    50                  55                  60                  


Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala 
                85                  90                  95      


Ser Ile Asn Ile Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  25
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(351)

<400>  25
cag tcg gtg gag gag tcc ggg ggt cgc ctg gtc acg cct ggg aca ccc         48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro           
1               5                   10                  15                

ctg aca ctc acc tgc aca gtc tct gga atc gac ctc agt agc aat gca         96
Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala           
            20                  25                  30                    

atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gaa tat atc gga        144
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly           
        35                  40                  45                        

att att agg aat aat gat atc aca tac tac gcg agc tgg gcg aaa ggc        192
Ile Ile Arg Asn Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly           
    50                  55                  60                            

cga ttc acc atc tcc aaa acc tcg acc acg gtg gat ctg ata atc acc        240
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Ile Ile Thr           
65                  70                  75                  80            

agt ccg aca acc gag gac acg gcc acc tat ttc tgt gcc aga ggg ggt        288
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly           
                85                  90                  95                

ggt tct tac agt att gtc ttc tgg aac tta tgg ggc cca ggc acc ctg        336
Gly Ser Tyr Ser Ile Val Phe Trp Asn Leu Trp Gly Pro Gly Thr Leu           
            100                 105                 110                   

gtc acc gtc tcc tca                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Arg Asn Asn Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Ile Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly 
                85                  90                  95      


Gly Ser Tyr Ser Ile Val Phe Trp Asn Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  27
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  derived from rabbit monoclonal


<220>
<221>  CDS
<222>  (1)..(339)

<400>  27
gcc aga tgt gcc tat gat atg acc cag act cca gcc tct gtg gag gta         48
Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val           
1               5                   10                  15                

gct gtg gga ggc aca gtc acc atc aat tgc cag gcc agt gag agg att         96
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Arg Ile           
            20                  25                  30                    

tat agc aat tta gcc tgg tat cag cag aaa cca ggg cag cgt ccc aaa        144
Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys           
        35                  40                  45                        

ctc ctg atc tat tat gca tcc act ctg gca tct ggg gtc tca tcg cgg        192
Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg           
    50                  55                  60                            

ttc aaa ggc agt gga tct ggg aca cag ttc act ctc acc atc agc ggc        240
Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly           
65                  70                  75                  80            

gtg cag tgt gcc gat gct gcc act tac tac tgt cag cag ggt tat agt        288
Val Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser           
                85                  90                  95                

aat aat aat gtt gac aat act ttc ggc gga ggg acc gag gtg gtg gtc        336
Asn Asn Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val           
            100                 105                 110                   

aga                                                                    339
Arg                                                                       
                                                                          


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val 
1               5                   10                  15      


Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Arg Ile 
            20                  25                  30          


Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg 
    50                  55                  60                  


Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Val Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser 
                85                  90                  95      


Asn Asn Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Arg 
    


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from human VH domain

<400>  29

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from human VH domain

<400>  30

Ile Ser Tyr Asp Val Ser Asn Lys 
1               5               


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from human VH domain

<400>  31

Ala Arg Ser Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from human VL domain

<400>  32

Gln Ser Ile Ser Arg Tyr 
1               5       


<210>  33
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from human VL domain

<400>  33

Asp Ala Ser 
1               


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Derived from human VL domain

<400>  34

Gln Gln Phe Gly Arg Ser Pro Arg Thr 
1               5                   


<210>  35
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Derived from human variable domain and human Ig domain


<220>
<221>  CDS
<222>  (1)..(1350)

<400>  35
gag gtg caa ctg gtg gag tct ggg gga ggt gtg gta agg cct ggg ggg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

gct atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt ata tca tat gat gta agc aat aaa tac tac gca gac tcc gtg        192
Ala Val Ile Ser Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gct gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga tct tac tac tac tac tac ggt atg gac gtc tgg ggc caa ggg        336
Ala Arg Ser Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tca gcc tcc act aag ggc cca tcc gtg ttc        384
Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe           
        115                 120                 125                       

cca ctg gca ccc tct agt aag agc aca tct ggg ggt act gcc gct ctg        432
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu           
    130                 135                 140                           

gga tgt ctg gtg aag gat tac ttc cca gag cca gtc acc gtg tcc tgg        480
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp           
145                 150                 155                 160           

aac agc ggg gcc ctg act tcc ggt gtc cat acc ttt cca gct gtg ctg        528
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu           
                165                 170                 175               

cag tca tcc ggc ctg tac agc ctg agc tct gtg gtc acc gtc ccc agt        576
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser           
            180                 185                 190                   

tca tcc ctg gga aca cag act tat atc tgc aac gtg aat cac aag cca        624
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro           
        195                 200                 205                       

tcc aat aca aaa gtc gac aag aaa gtg gaa ccc aag agc tgt gat aaa        672
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys           
    210                 215                 220                           

acc cat aca tgc ccc cct tgt cct gct cca gag ctg ctg gga gga cca        720
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro           
225                 230                 235                 240           

tcc gtg ttc ctg ttt cca ccc aag cct aaa gac act ctg atg att tct        768
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser           
                245                 250                 255               

cga acc ccc gaa gtc aca tgc gtg gtc gtg gac gtg tcc cac gag gat        816
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp           
            260                 265                 270                   

cct gaa gtc aag ttc aac tgg tac gtg gat ggc gtc gag gtg cat aat        864
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn           
        275                 280                 285                       

gcc aag aca aaa cca cga gag gaa cag tac aac agt acc tat cgt gtc        912
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val           
    290                 295                 300                           

gtg tca gtc ctg aca gtg ctg cac cag gac tgg ctg aac ggg aag gaa        960
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu           
305                 310                 315                 320           

tat aag tgc aaa gtg agc aat aag gca ctg ccc gcc cct atc gag aaa       1008
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys           
                325                 330                 335               

aca att tct aag gct aaa gga cag cct agg gaa cca cag gtg tac act       1056
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr           
            340                 345                 350                   

ctg cct cca tca cgg gac gag ctg aca aag aac cag gtc agt ctg act       1104
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr           
        355                 360                 365                       

tgt ctg gtg aaa ggg ttc tat cct tct gat atc gcc gtg gag tgg gaa       1152
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu           
    370                 375                 380                           

agt aat ggt cag cca gag aac aat tac aag acc aca ccc cct gtc ctg       1200
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu           
385                 390                 395                 400           

gac tct gat ggg agt ttc ttt ctg tat tcc aag ctg acc gtg gat aaa       1248
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys           
                405                 410                 415               

agc cgg tgg cag cag ggt aat gtc ttt agt tgt tca gtg atg cac gag       1296
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu           
            420                 425                 430                   

gca ctg cac aat cac tac acc cag aaa tca ctg tca ctg tca cca ggt       1344
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly           
        435                 440                 445                       

aaa tga                                                               1350
Lys                                                                       
                                                                          


<210>  36
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  37
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Derived from human variable domain and human Ig domain


<220>
<221>  CDS
<222>  (1)..(645)

<400>  37
gat gtt gtg atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agg tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr           
            20                  25                  30                    

tta gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc aac agg gcc act ggc atc cca gtc agg ttc agt ggc        192
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag cca        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtg tat tac tgt cag cag ttt ggt agg tca cct cgg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro Arg           
                85                  90                  95                

acg ttc ggc caa ggg aca cga ctg gag att aaa cga act gtg gct gca        336
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala           
            100                 105                 110                   

cca tct gtc ttc atc ttc ccg cca tct gat gag cag ttg aaa tct gga        384
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly           
        115                 120                 125                       

act gcc tct gtt gtg tgc ctg ctg aat aac ttc tat ccc aga gag gcc        432
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala           
    130                 135                 140                           

aaa gta cag tgg aag gtg gat aac gcc ctc caa tcg ggt aac tcc cag        480
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln           
145                 150                 155                 160           

gag agt gtc aca gag cag gac agc aag gac agc acc tac agc ctc agc        528
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser           
                165                 170                 175               

agc acc ctg acg ctg agc aaa gca gac tac gag aaa cac aaa gtc tac        576
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr           
            180                 185                 190                   

gcc tgc gaa gtc acc cat cag ggc ctg agc tcg ccc gtc aca aag agc        624
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser           
        195                 200                 205                       

ttc aac agg gga gag tgt tag                                            645
Phe Asn Arg Gly Glu Cys                                                   
    210                                                                   


<210>  38
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  39
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Derived from human variable domains


<220>
<221>  CDS
<222>  (1)..(732)

<400>  39
gat gtt gtg atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cgg gca agt cag agc att agc agg tac         96
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr           
            20                  25                  30                    

tta gcc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc aac agg gcc act ggc atc cca gtc agg ttc agt ggc        192
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc aga ctg gag cca        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtg tat tac tgt cag cag ttt ggt agg tca cct cgg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro Arg           
                85                  90                  95                

acg ttc ggc caa ggg aca cga ctg gag att aaa ggc gga tcc tct agg        336
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Ser Ser Arg           
            100                 105                 110                   

tca agt tcc agc ggc ggc ggt ggc agc gga ggc ggc ggt gag gtg caa        384
Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln           
        115                 120                 125                       

ctg gtg gag tct ggg gga ggt gtg gta agg cct ggg ggg tcc ctg aga        432
Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg           
    130                 135                 140                           

ctc tcc tgt gca gcc tct gga ttc acc ttc agt agc tat gct atg cac        480
Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His           
145                 150                 155                 160           

tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg gca gtt ata        528
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile           
                165                 170                 175               

tca tat gat gta agc aat aaa tac tac gca gac tcc gtg aag ggc cga        576
Ser Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg           
            180                 185                 190                   

ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat ctg caa atg        624
Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met           
        195                 200                 205                       

aac agc ctg aga gct gag gac acg gct gtg tat tac tgt gcg aga tct        672
Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser           
    210                 215                 220                           

tac tac tac tac tac ggt atg gac gtc tgg ggc caa ggg acc acg gtc        720
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val           
225                 230                 235                 240           

acc gtc tcc tca                                                        732
Thr Val Ser Ser                                                           
                                                                          


<210>  40
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Val Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Gly Arg Ser Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Gly Gly Ser Ser Arg 
            100                 105                 110         


Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile 
                165                 170                 175     


Ser Tyr Asp Val Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser 
    210                 215                 220                 


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  41
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(351)

<400>  41
cag tcg gtg gag gag tcc ggg ggt cgc ctg gtc acg cct ggg aca ccc         48
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro           
1               5                   10                  15                

ctg aca ctc acc tgc aca gtc tct gga atc gac ctc agt aac aat gca         96
Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn Asn Ala           
            20                  25                  30                    

atg agc tgg gtc cgc cag gct cca ggg aag ggg ctg gaa tat atc gga        144
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly           
        35                  40                  45                        

atc att agg agt agt ggt agt aca tat tac gcg aac tgg gca aaa ggc        192
Ile Ile Arg Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly           
    50                  55                  60                            

cgg ttc acc atc tcc aaa acc tcg acc acg gtg gat ctg ata atc acc        240
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Ile Ile Thr           
65                  70                  75                  80            

agt ccg aca acc gag gac acg gcc acc tat ttc tgt gcc aga ggg ggt        288
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly           
                85                  90                  95                

ggt tct tac agt att gtc ttc tgg aac ttg tgg ggc cca ggc acc ctg        336
Gly Ser Tyr Ser Ile Val Phe Trp Asn Leu Trp Gly Pro Gly Thr Leu           
            100                 105                 110                   

gtc acc gtc tcc tca                                                    351
Val Thr Val Ser Ser                                                       
        115                                                               


<210>  42
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Asn Asn Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Arg Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Ile Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly 
                85                  90                  95      


Gly Ser Tyr Ser Ile Val Phe Trp Asn Leu Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  43
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(342)

<400>  43
gcc aga tgt gcc tat gat atg acc cag act cca gcc tct gtg gag gta         48
Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val           
1               5                   10                  15                

gct gtg gga ggc aca gtc acc atc aat tgc cag gcc agt gag agg att         96
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Arg Ile           
            20                  25                  30                    

tat agc aat tta gcc tgg tat cag cag aaa cca ggg cag cgt ccc aag        144
Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys           
        35                  40                  45                        

ctc ctg atc tat tat aca tcc act ctg gca tct ggg gtc tca tcg cgg        192
Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg           
    50                  55                  60                            

ttc aaa ggc agt gga tct ggg aca cag ttc act ctc acc atc agc ggc        240
Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly           
65                  70                  75                  80            

gtg gag tgt gcc gat gct gcc act tac tac tgt caa cag ggt tat agt        288
Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser           
                85                  90                  95                

agt agt aat gtt gac aat act ttc ggc gga ggg acc gag gtg gtg gtc        336
Ser Ser Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val           
            100                 105                 110                   

aaa ggt                                                                342
Lys Gly                                                                   
                                                                          


<210>  44
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val 
1               5                   10                  15      


Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Arg Ile 
            20                  25                  30          


Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Ala Ser Gly Val Ser Ser Arg 
    50                  55                  60                  


Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser 
                85                  90                  95      


Ser Ser Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Gly 
        


<210>  45
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(363)

<400>  45
ggc gag cag cag ctg gtg gag agc ggc gga ggc ctg gtg cag cct gga         48
Gly Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly           
1               5                   10                  15                

gga agc ctg agg ctg agc tgc gcc gtg tcc ggc ttc agc ctg agc agc         96
Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser           
            20                  25                  30                    

tac gcc atc agc tgg gtg agg cag gcc ccc gga aag ggc ctg gag tac        144
Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr           
        35                  40                  45                        

atc gcc atc atc aac agc tac ggc acc acc tac tac gcc agc tgg gcc        192
Ile Ala Ile Ile Asn Ser Tyr Gly Thr Thr Tyr Tyr Ala Ser Trp Ala           
    50                  55                  60                            

aag ggc aga gtg acc atc tcc aag gat tcc tcc aag aac acc gtg tac        240
Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr           
65                  70                  75                  80            

ctg cag atg ggc tcc ctg aga gcc gag gat atg gcc gtg tac ttt tgc        288
Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys           
                85                  90                  95                

gcc aga ggc gat tcc tac ggc tcc ggc gtg ggc ctg ggc ctg tgg gga        336
Ala Arg Gly Asp Ser Tyr Gly Ser Gly Val Gly Leu Gly Leu Trp Gly           
            100                 105                 110                   

cct gga acc ctg gtg aca gtg tcc tcc                                    363
Pro Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  46
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Gly Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser 
            20                  25                  30          


Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Ala Ile Ile Asn Ser Tyr Gly Thr Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Tyr Gly Ser Gly Val Gly Leu Gly Leu Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(333)

<400>  47
gga gac tac cag atg aca cag tcc cct agc acc ctg tcc gcc tcc gtg         48
Gly Asp Tyr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val           
1               5                   10                  15                

ggc gac aga gtg aca atc acc tgt cag gcc tcc cag aat atc tac agc         96
Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser           
            20                  25                  30                    

aat ctg gcc tgg tac cag cag aag cct ggc aag agg ccc aag ctg ctg        144
Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu           
        35                  40                  45                        

atc tac aga gcc agc tcc ctg gcc tcc ggc gtg cca tct aga ttt tcc        192
Ile Tyr Arg Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser           
    50                  55                  60                            

ggc tcc ggc agc ggc aca gag ttt acc ctg aca atc agc agc ctg cag        240
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

ccc gat gat ttc gcc acc tac tac tgt cag cag ggc ttc agc agc aat        288
Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Asn           
                85                  90                  95                

aat gtg gac aat aca ttt ggc ggc ggc aca aag gtg gag atc aag            333
Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  48
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Gly Asp Tyr Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Arg Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Ser Ser Asn 
                85                  90                  95      


Asn Val Asp Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  49
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(354)

<400>  49
ggc gag cag cag ctg gtg gag agc ggc gga ggc ctg gtg cag cct gga         48
Gly Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly           
1               5                   10                  15                

gga agc ctg agg ctg agc tgc gcc gtg tcc ggc ttt tcc ctg agc aag         96
Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Lys           
            20                  25                  30                    

agc atc atc agc tgg gtg agg cag gcc cct ggc aag ggc ctg gag tac        144
Ser Ile Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr           
        35                  40                  45                        

atc ggc atc atc ggc agc agc ggc tcc acc tac tac gcc aac tgg gcc        192
Ile Gly Ile Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala           
    50                  55                  60                            

aag ggc aga ttc aca atc tcc aag gac tcc tcc aag aat acc gtg tac        240
Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr           
65                  70                  75                  80            

ctg cag atg ggc tcc ctg agg gcc gag gat atg gcc gtg tac ttt tgt        288
Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys           
                85                  90                  95                

gcc aga ggc ctg ctg tac tcc ggc aat aag tcc tgg ggc ccc ggc aca        336
Ala Arg Gly Leu Leu Tyr Ser Gly Asn Lys Ser Trp Gly Pro Gly Thr           
            100                 105                 110                   

ctg gtg acc gtg agc tcc                                                354
Leu Val Thr Val Ser Ser                                                   
        115                                                               


<210>  50
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Gly Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Lys 
            20                  25                  30          


Ser Ile Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Ile Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Tyr Ser Gly Asn Lys Ser Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  51
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(333)

<400>  51
ggc gac atc gtg atg acc cag tcc ccc gat tcc ctg gcc gtg tcc ctg         48
Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu           
1               5                   10                  15                

ggc gag aga gcc aca atc aat tgt cag tcc tcc cag agc gtg ctg ctg         96
Gly Glu Arg Ala Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Leu Leu           
            20                  25                  30                    

aac aat cag ctg tcc tgg ttc cag cag aag cct ggc cag cct ccc aag        144
Asn Asn Gln Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys           
        35                  40                  45                        

ctg ctg atc tac gac gcc tcc aca ctg gag tcc ggc gtg ccc gat agg        192
Leu Leu Ile Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Asp Arg           
    50                  55                  60                            

ttc agc ggc tcc ggc agc ggc acc gac ttt acc ctg acc atc tcc agc        240
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser           
65                  70                  75                  80            

ctg cag gcc gag gat gtg gcc gtg tac tac tgc ctg ggc ggc tac agc        288
Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gly Gly Tyr Ser           
                85                  90                  95                

ggc aac ctg tac gcc ttt ggc ggc ggc acc aag gtg gag atc aag            333
Gly Asn Leu Tyr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  52
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
1               5                   10                  15      


Gly Glu Arg Ala Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Leu Leu 
            20                  25                  30          


Asn Asn Gln Leu Ser Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gly Gly Tyr Ser 
                85                  90                  95      


Gly Asn Leu Tyr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  53
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(369)

<400>  53
ggc gag cag cag ctg gtg gag tcc ggc gga ggc ctg gtg cag cca gga         48
Gly Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly           
1               5                   10                  15                

gga agc ctg agg ctg tcc tgt gcc gtg agc ggc ttc tcc ctg agc tcc         96
Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser           
            20                  25                  30                    

tac gcc atg agc tgg gtg agg cag gcc ccc gga aag ggc ctg gag tac        144
Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr           
        35                  40                  45                        

atc ggc atc atc agc agc agc ggc agc aca tac tac gcc agc tgg gcc        192
Ile Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala           
    50                  55                  60                            

aag ggc agg ttc aca atc agc aag gat tcc tcc aag aat aca gtg tac        240
Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr           
65                  70                  75                  80            

ctg cag atg ggc tcc ctg agg gcc gag gac atg gcc gtg tac ttc tgt        288
Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys           
                85                  90                  95                

gcc aga gac agg gtc atc tat tcc atc ggc cct tac tac ttc aac ctg        336
Ala Arg Asp Arg Val Ile Tyr Ser Ile Gly Pro Tyr Tyr Phe Asn Leu           
            100                 105                 110                   

tgg ggc ccc ggc aca ctg gtg aca gtg tcc agc                            369
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser                               
        115                 120                                           


<210>  54
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gly Glu Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Ser Ser 
            20                  25                  30          


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr 
        35                  40                  45              


Ile Gly Ile Ile Ser Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Val Ile Tyr Ser Ile Gly Pro Tyr Tyr Phe Asn Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  55
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chimeric sequences


<220>
<221>  CDS
<222>  (1)..(333)

<400>  55
ggc gat tac cag atg aca cag tcc ccc tcc tcc ctg agc gcc tcc gtg         48
Gly Asp Tyr Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val           
1               5                   10                  15                

gga gat agg gtg acc atc aca tgc cag gcc agc gag atc atc tac agc         96
Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ile Ile Tyr Ser           
            20                  25                  30                    

aat ctg gcc tgg tac cag cag aag ccc ggc aag ccc ccc aag ctg ctg        144
Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu           
        35                  40                  45                        

atc tac ggc gcc tcc aca ctg gcc agc ggc gtg cct agc aga ttc agc        192
Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser           
    50                  55                  60                            

ggc agc ggc tcc ggc acc gat tac acc ctg aca atc tcc agc ctg cag        240
Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln           
65                  70                  75                  80            

cct gag gat ttt gcc aca tac tac tgt cag cag tcc ttc agc tcc aat        288
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Ser Asn           
                85                  90                  95                

aac gtg ggc aac atc ttc ggc ggc ggc aca aag gtg gag atc aag            333
Asn Val Gly Asn Ile Phe Gly Gly Gly Thr Lys Val Glu Ile Lys               
            100                 105                 110                   


<210>  56
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Gly Asp Tyr Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Ile Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Ser Asn 
                85                  90                  95      


Asn Val Gly Asn Ile Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


