                         SEQUENCE LISTING

<110>  The Regents of the University of California
        
<120>  Antibody Chemically Induced Dimerizers (AbCID) As Molecular 
       Switches And Uses Thereof

<130>  048536-650001WO

<150>  US 62/885,164
<151>  2019-08-09

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC1 HC-CDR1 (cereblon + thalidomide)

<400>  1

Ile Ser Ser Tyr Ser Ile 
1               5       


<210>  2
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC2 HC-CDR1 (cereblon + thalidomide)

<400>  2

Val Ser Ser Ser Ser Ile 
1               5       


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-LC1 HC-CDR1 (cereblon + lenalidomide)

<400>  3

Phe Ser Ser Ser Ser Ile 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC1 HC-CDR1 (cereblon + pomalidomide)

<400>  4

Val Ser Ser Tyr Ser Ile 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC2 HC-CDR1 (cereblon + pomalidomide)

<400>  5

Val Ser Tyr Ser Ser Ile 
1               5       


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC1 HC-CDR2 (cereblon + thalidomide)

<400>  6

Ser Ile Ser Pro Ser Tyr Gly Tyr Thr Ser 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC2 HC-CDR2 (cereblon + thalidomide)

<400>  7

Ser Ile Tyr Ser Tyr Tyr Gly Ser Thr Tyr 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-LC1 HC-CDR2 (cereblon + lenalidomide)

<400>  8

Tyr Ile Ser Ser Ser Ser Gly Ser Thr Ser 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC1 HC-CDR2 (cereblon + pomalidomide)

<400>  9

Ser Ile Ser Ser Tyr Ser Gly Ser Thr Ser 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC2 HC-CDR2 (cereblon + pomalidomide)

<400>  10

Ser Ile Tyr Ser Tyr Ser Gly Ser Thr Ser 
1               5                   10  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC1 HC-CDR3 (cereblon + thalidomide)

<400>  11

Ser Tyr Tyr Trp Gln Tyr Tyr Tyr Gln Phe Gly Tyr Pro Phe Gly Phe 
1               5                   10                  15      


<210>  12
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC2 HC-CDR3 (cereblon + thalidomide)

<400>  12

Thr Asp Ser Trp Tyr Tyr Tyr Arg Tyr Gly Gly Met 
1               5                   10          


<210>  13
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-LC1 HC-CDR3 (cereblon + lenalidomide)

<400>  13

Ser Glu Tyr Pro Tyr Ser Tyr Trp Tyr Met Tyr Gly Tyr Pro Val Gly 
1               5                   10                  15      


Gly Phe 
        


<210>  14
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC1 HC-CDR3 (cereblon + pomalidomide)

<400>  14

Ser Tyr Phe Val Glu Tyr Tyr Tyr Tyr Tyr Gly Trp Pro Trp Gly Leu 
1               5                   10                  15      


<210>  15
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC2 HC-CDR3 (cereblon + pomalidomide)

<400>  15

Ser Ser Tyr Ser Tyr Trp Tyr Tyr Ile Met Tyr Gly Tyr Trp Phe Ala 
1               5                   10                  15      


Met 
    


<210>  16
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC1 LC-CDR3 (cereblon + thalidomide)

<400>  16

Gly Ser Gln Ser Gln Met Pro Phe 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-TC2 LC-CDR3 (cereblon + thalidomide)

<400>  17

Tyr Ser Trp Trp Trp Met Pro Ile 
1               5               


<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-LC1 LC-CDR3 (cereblon + lenalidomide)

<400>  18

Trp Gly Tyr Tyr Leu Ile 
1               5       


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC1 LC-CDR3 (cereblon + pomalidomide)

<400>  19

Ser Ser Tyr Ser Tyr Leu Phe 
1               5           


<210>  20
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Fab-PC2 LC-CDR3 (cereblon + pomalidomide)

<400>  20

Ser Asp Ser Met Pro Val 
1               5       


<210>  21
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  LC-CDR1

<400>  21

Arg Ala Ser Gln Ser Val Ser Ser Ala Val Ala 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  LC-CDR2

<400>  22

Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210>  23
<211>  246
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Heavy Chain Scaffold

<400>  23

Glu Ile Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe 
            20                  25                  30          


Ser Ser Ser Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Ser Ile Ser Ser Ser Tyr Gly Tyr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser 
            100                 105                 110         


Gly Trp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Gly Gly Ser 
225                 230                 235                 240 


His His His His His His 
                245     


<210>  24
<211>  226
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  Light Chain Scaffold

<400>  24

Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Tyr Ser Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Ser Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Asp Tyr Lys Asp Asp Asp 
    210                 215                 220                 


Asp Lys 
225     


<210>  25
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<223>  IMiD-binding domain of cereblon

<400>  25

Thr Ser Leu Cys Cys Lys Gln Cys Gln Glu Thr Glu Ile Thr Thr Lys 
1               5                   10                  15      


Asn Glu Ile Phe Ser Leu Ser Leu Cys Gly Pro Met Ala Ala Tyr Val 
            20                  25                  30          


Asn Pro His Gly Tyr Val His Glu Thr Leu Thr Val Tyr Lys Ala Cys 
        35                  40                  45              


Asn Leu Asn Leu Ile Gly Arg Pro Ser Thr Glu His Ser Trp Phe Pro 
    50                  55                  60                  


Gly Tyr Ala Trp Thr Val Ala Gln Cys Lys Ile Cys Ala Ser His Ile 
65                  70                  75                  80  


Gly Trp Lys Phe Thr Ala Thr Lys Lys Asp Met Ser Pro Gln Lys Phe 
                85                  90                  95      


Trp Gly Leu Thr Arg Ser Ala Leu Leu Pro Thr Ile Pro 
            100                 105                 


