<110>    Medicinal Bioconvergence Research Center
         Industry-Academic Cooperation Foundation, Yonsei University

<120>    Method for diagnosing lung cancer using methionyl-tRNA synthetase
         and pan-cytokeratin

<130>    OP19-0176/PCT

<150>    KR 10-2019-0099693
<151>    2019-08-14

<160>    1

<170>    KopatentIn 2.0

<210>    1
<211>    900
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    human MRS amino acid sequence


<400>    1
Met Arg Leu Phe Val Ser Asp Gly Val Pro Gly Cys Leu Pro Val Leu
  1               5                  10                  15 

Ala Ala Ala Gly Arg Ala Arg Gly Arg Ala Glu Val Leu Ile Ser Thr
             20                  25                  30 

Val Gly Pro Glu Asp Cys Val Val Pro Phe Leu Thr Arg Pro Lys Val
         35                  40                  45 

Pro Val Leu Gln Leu Asp Ser Gly Asn Tyr Leu Phe Ser Thr Ser Ala
     50                  55                  60 

Ile Cys Arg Tyr Phe Phe Leu Leu Ser Gly Trp Glu Gln Asp Asp Leu
 65                  70                  75                  80 

Thr Asn Gln Trp Leu Glu Trp Glu Ala Thr Glu Leu Gln Pro Ala Leu
                 85                  90                  95 

Ser Ala Ala Leu Tyr Tyr Leu Val Val Gln Gly Lys Lys Gly Glu Asp
            100                 105                 110 

Val Leu Gly Ser Val Arg Arg Ala Leu Thr His Ile Asp His Ser Leu
        115                 120                 125 

Ser Arg Gln Asn Cys Pro Phe Leu Ala Gly Glu Thr Glu Ser Leu Ala
    130                 135                 140 

Asp Ile Val Leu Trp Gly Ala Leu Tyr Pro Leu Leu Gln Asp Pro Ala
145                 150                 155                 160 

Tyr Leu Pro Glu Glu Leu Ser Ala Leu His Ser Trp Phe Gln Thr Leu
                165                 170                 175 

Ser Thr Gln Glu Pro Cys Gln Arg Ala Ala Glu Thr Val Leu Lys Gln
            180                 185                 190 

Gln Gly Val Leu Ala Leu Arg Pro Tyr Leu Gln Lys Gln Pro Gln Pro
        195                 200                 205 

Ser Pro Ala Glu Gly Arg Ala Val Thr Asn Glu Pro Glu Glu Glu Glu
    210                 215                 220 

Leu Ala Thr Leu Ser Glu Glu Glu Ile Ala Met Ala Val Thr Ala Trp
225                 230                 235                 240 

Glu Lys Gly Leu Glu Ser Leu Pro Pro Leu Arg Pro Gln Gln Asn Pro
                245                 250                 255 

Val Leu Pro Val Ala Gly Glu Arg Asn Val Leu Ile Thr Ser Ala Leu
            260                 265                 270 

Pro Tyr Val Asn Asn Val Pro His Leu Gly Asn Ile Ile Gly Cys Val
        275                 280                 285 

Leu Ser Ala Asp Val Phe Ala Arg Tyr Ser Arg Leu Arg Gln Trp Asn
    290                 295                 300 

Thr Leu Tyr Leu Cys Gly Thr Asp Glu Tyr Gly Thr Ala Thr Glu Thr
305                 310                 315                 320 

Lys Ala Leu Glu Glu Gly Leu Thr Pro Gln Glu Ile Cys Asp Lys Tyr
                325                 330                 335 

His Ile Ile His Ala Asp Ile Tyr Arg Trp Phe Asn Ile Ser Phe Asp
            340                 345                 350 

Ile Phe Gly Arg Thr Thr Thr Pro Gln Gln Thr Lys Ile Thr Gln Asp
        355                 360                 365 

Ile Phe Gln Gln Leu Leu Lys Arg Gly Phe Val Leu Gln Asp Thr Val
    370                 375                 380 

Glu Gln Leu Arg Cys Glu His Cys Ala Arg Phe Leu Ala Asp Arg Phe
385                 390                 395                 400 

Val Glu Gly Val Cys Pro Phe Cys Gly Tyr Glu Glu Ala Arg Gly Asp
                405                 410                 415 

Gln Cys Asp Lys Cys Gly Lys Leu Ile Asn Ala Val Glu Leu Lys Lys
            420                 425                 430 

Pro Gln Cys Lys Val Cys Arg Ser Cys Pro Val Val Gln Ser Ser Gln
        435                 440                 445 

His Leu Phe Leu Asp Leu Pro Lys Leu Glu Lys Arg Leu Glu Glu Trp
    450                 455                 460 

Leu Gly Arg Thr Leu Pro Gly Ser Asp Trp Thr Pro Asn Ala Gln Phe
465                 470                 475                 480 

Ile Thr Arg Ser Trp Leu Arg Asp Gly Leu Lys Pro Arg Cys Ile Thr
                485                 490                 495 

Arg Asp Leu Lys Trp Gly Thr Pro Val Pro Leu Glu Gly Phe Glu Asp
            500                 505                 510 

Lys Val Phe Tyr Val Trp Phe Asp Ala Thr Ile Gly Tyr Leu Ser Ile
        515                 520                 525 

Thr Ala Asn Tyr Thr Asp Gln Trp Glu Arg Trp Trp Lys Asn Pro Glu
    530                 535                 540 

Gln Val Asp Leu Tyr Gln Phe Met Ala Lys Asp Asn Val Pro Phe His
545                 550                 555                 560 

Ser Leu Val Phe Pro Cys Ser Ala Leu Gly Ala Glu Asp Asn Tyr Thr
                565                 570                 575 

Leu Val Ser His Leu Ile Ala Thr Glu Tyr Leu Asn Tyr Glu Asp Gly
            580                 585                 590 

Lys Phe Ser Lys Ser Arg Gly Val Gly Val Phe Gly Asp Met Ala Gln
        595                 600                 605 

Asp Thr Gly Ile Pro Ala Asp Ile Trp Arg Phe Tyr Leu Leu Tyr Ile
    610                 615                 620 

Arg Pro Glu Gly Gln Asp Ser Ala Phe Ser Trp Thr Asp Leu Leu Leu
625                 630                 635                 640 

Lys Asn Asn Ser Glu Leu Leu Asn Asn Leu Gly Asn Phe Ile Asn Arg
                645                 650                 655 

Ala Gly Met Phe Val Ser Lys Phe Phe Gly Gly Tyr Val Pro Glu Met
            660                 665                 670 

Val Leu Thr Pro Asp Asp Gln Arg Leu Leu Ala His Val Thr Leu Glu
        675                 680                 685 

Leu Gln His Tyr His Gln Leu Leu Glu Lys Val Arg Ile Arg Asp Ala
    690                 695                 700 

Leu Arg Ser Ile Leu Thr Ile Ser Arg His Gly Asn Gln Tyr Ile Gln
705                 710                 715                 720 

Val Asn Glu Pro Trp Lys Arg Ile Lys Gly Ser Glu Ala Asp Arg Gln
                725                 730                 735 

Arg Ala Gly Thr Val Thr Gly Leu Ala Val Asn Ile Ala Ala Leu Leu
            740                 745                 750 

Ser Val Met Leu Gln Pro Tyr Met Pro Thr Val Ser Ala Thr Ile Gln
        755                 760                 765 

Ala Gln Leu Gln Leu Pro Pro Pro Ala Cys Ser Ile Leu Leu Thr Asn
    770                 775                 780 

Phe Leu Cys Thr Leu Pro Ala Gly His Gln Ile Gly Thr Val Ser Pro
785                 790                 795                 800 

Leu Phe Gln Lys Leu Glu Asn Asp Gln Ile Glu Ser Leu Arg Gln Arg
                805                 810                 815 

Phe Gly Gly Gly Gln Ala Lys Thr Ser Pro Lys Pro Ala Val Val Glu
            820                 825                 830 

Thr Val Thr Thr Ala Lys Pro Gln Gln Ile Gln Ala Leu Met Asp Glu
        835                 840                 845 

Val Thr Lys Gln Gly Asn Ile Val Arg Glu Leu Lys Ala Gln Lys Ala
    850                 855                 860 

Asp Lys Asn Glu Val Ala Ala Glu Val Ala Lys Leu Leu Asp Leu Lys
865                 870                 875                 880 

Lys Gln Leu Ala Val Ala Glu Gly Lys Pro Pro Glu Ala Pro Lys Gly
                885                 890                 895 

Lys Lys Lys Lys
            900
