                         SEQUENCE LISTING

<110>  Biond Biologics LTD
 
<120>  ANTIBODIES AGAINST ILT2 AND USE THEREOF

<130>  BDB-P-002-PCT

<150>  62/885,374
<151>  2019-08-12

<150>  63/034,569
<151>  2020-06-04

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Asp His Thr Ile His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Tyr Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Thr Trp Asp Tyr Phe Asp Tyr 
1               5           


<210>  4
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Gly Tyr Thr Phe Thr Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Glu Ile Tyr Pro Gly Ser Gly Asn Ser Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Ser Asn Asp Gly Tyr Pro Asp Tyr 
1               5               


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Gln Gln Tyr Trp Ser Thr Pro Trp Thr 
1               5                   


<210>  13
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  14
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  15
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (10)..(10)
<223>  X is selected from A, C and S.

<400>  15

Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Xaa 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Arg Thr Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Gln Gln Gly Asn Thr Leu Pro Thr 
1               5               


<210>  19
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Gln Val Gln Leu Gln Gln Ser Asp Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp His 
            20                  25                  30          


Thr Ile His Trp Met Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Arg Asp Gly Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Trp Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  20
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  21
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Ser Gly Asn Ser Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Asn Asp Gly Tyr Pro Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  22
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  X
<222>  (108)..(108)
<223>  X is selected from A, C and S.

<400>  23

Asp Val Gln Leu Gln Gly Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Thr Ile Ser Arg Asp Thr Asp Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Xaa Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ser Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  25
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Ala 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Ser 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Cys 
1               5                   10  


<210>  28
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Asp Val Gln Leu Gln Gly Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Thr Ile Ser Arg Asp Thr Asp Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ser Val Thr Val 
        115             


<210>  29
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  29

Asp Val Gln Leu Gln Gly Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Thr Ile Ser Arg Asp Thr Asp Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Ser Val Thr Val 
        115             


<210>  30
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Asp Val Gln Leu Gln Gly Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Tyr Ser Tyr Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly 
        435                 440                 445             


Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile Gly 
    450                 455                 460                 


Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe 
465                 470                 475                 480 


Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln 
                485                 490                 495     


Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro 
            500                 505                 510         


Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln 
        515                 520                 525             


Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly 
    530                 535                 540                 


Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val 
545                 550                 555                 560 


Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser 
                565                 570                 575     


Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln 
            580                 585                 590         


Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala 
        595                 600                 605             


Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg 
    610                 615                 620                 


Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val 
625                 630                 635                 640 


Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650 


<210>  32
<211>  351
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  32
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcaca agctatggta taagctgggt gaagcagaga      120

actggacagg gccttgagtg ggttggagag atttatcctg gaagtggtaa ttcttactac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac      240

atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagatcgaat      300

gatggttacc ctgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  33
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  33
gatgtacagc ttcaggggtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtggttatt actggaactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacataagct acgatggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac ttctgaggac acagccacat attactgtgc ccatggttac      300

tcatattact atgctatgga ctgctggggt caaggaacct cagtcaccgt ctcctca         357


<210>  34
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  34
gatgtccagc tgcaaggctc tggccctgga ctggttaagc cttccgagac actgtccctg       60

acctgctctg tgaccggcta ctctatcacc tccggctact actggaactg gatcagacag      120

ttccccggca agaaactgga atggatgggc tacatctcct acgacggctc caacaactac      180

aaccccagcc tgaagaaccg gatcaccatc tctcgggaca cctccaagaa ccagttctcc      240

ctgaagctga actccgtgac cgctgccgat accgctacct actactgtgc tcacggctac      300

tcctactact acgccatgga tgcttggggc cagggcacat ctgtgacagt gtcctct         357


<210>  35
<211>  348
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  35
caggttcagc tgcaacagtc tgacgctgag ttggtgaaac ctggagcttc agtgaagata       60

tcctgcaagg tttctggcta caccttcact gaccatacta ttcactggat gaagcagagg      120

cctgaacagg gcctggaatg gattggatat atttatccta gagatggtag tactaagtac      180

aatgagaagt tcaagggcaa ggccacattg actgcagaca aatcctccag cacagcctac      240

atgcagctca acagcctgac atctgaggac tctgcagtct atttctgtgc aagaacctgg      300

gactactttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  36
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  36
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctat tactgtcagc aaagtaatga ggatccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  37
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  37
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca ggacaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctcctac acatcaagat tgcactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttcccacgtt cggctcgggg      300

acaaagttgg aaataaaa                                                    318


<210>  38
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  38
gacatccaga tgacccagtc tccatcctct ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc ggacctctca ggacatctcc aactacctga actggtatca gcagaaaccc      120

ggcaaggccg tgaagctgct gatctcctac acctccagac tgcactctgg cgtgccctcc      180

agattttctg gctctggatc tggcaccgac tacaccctga ccatcagttc tctgcagcct      240

gaggacttcg ccacctacta ctgtcagcag ggcaacaccc tgcctacctt tggccagggc      300

accaagctgg aaatcaag                                                    318


<210>  39
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  39
gacatccaga tgacacaatc ttcatcctac ttgtctgtat ctctaggagg cagagtcacc       60

attacttgca aggcaagtga ccacattaat aattggttag cctggtatca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca      180

agattcagtg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact      240

gaagatgttg ctacttatta ctgtcaacag tattggagta ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  40
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  40

His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile Thr 
1               5                   10                  15      


Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr Gln 
            20                  25                  30          


Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr Arg 
        35                  40                  45              


Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser Ile 
    50                  55                  60                  


Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp Thr 
65                  70                  75                  80  


Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr Gly 
                85                  90                  95      


Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Asn 
            100                 105                 110         


Ser Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala Phe Asp 
        115                 120                 125             


Gly Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu 
    130                 135                 140                 


Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val 
145                 150                 155                 160 


Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr Ala Tyr 
                165                 170                 175     


Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu Leu Glu 
            180                 185                 190         


Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Leu Ser Val Gln Pro 
        195                 200                 205             


Gly Pro Ile Val Ala Pro Glu Glu Thr Leu Thr Leu Gln Cys Gly Ser 
    210                 215                 220                 


Asp Ala Gly Tyr Asn Arg Phe Val Leu Tyr Lys Asp Gly Glu Arg Asp 
225                 230                 235                 240 


Phe Leu Gln Leu Ala Gly Ala Gln Pro Gln Ala Gly Leu Ser Gln Ala 
                245                 250                 255     


Asn Phe Thr Leu Gly Pro Val Ser Arg Ser Tyr Gly Gly Gln Tyr Arg 
            260                 265                 270         


Cys Tyr Gly Ala His Asn Leu Ser Ser Glu Trp Ser Ala Pro Ser Asp 
        275                 280                 285             


Pro Leu Asp Ile Leu Ile Ala Gly Gln Phe Tyr Asp Arg Val Ser Leu 
    290                 295                 300                 


Ser Val Gln Pro Gly Pro Thr Val Ala Ser Gly Glu Asn Val Thr Leu 
305                 310                 315                 320 


Leu Cys Gln Ser Gln Gly Trp Met Gln Thr Phe Leu Leu Thr Lys Glu 
                325                 330                 335     


Gly Ala Ala Asp Asp Pro Trp Arg Leu Arg Ser Thr Tyr Gln Ser Gln 
            340                 345                 350         


Lys Tyr Gln Ala Glu Phe Pro Met Gly Pro Val Thr Ser Ala His Ala 
        355                 360                 365             


Gly Thr Tyr Arg Cys Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu 
    370                 375                 380                 


Thr His Pro Ser Asp Pro Leu Glu Leu 
385                 390             


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Lys Lys Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Ile Leu Gln Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
1               5                   10                  15  


<210>  45
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Thr Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Ser Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  46
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile 
1               5                   10                  15      


Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr 
            20                  25                  30          


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Leu Trp Ile Thr 
        35                  40                  45              


Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser 
    50                  55                  60                  


Ile Thr Trp Glu His Ala Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp 
65                  70                  75                  80  


Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr 
                85                  90                  95      


Gly Ala 
        


<210>  47
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  47

Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Asn Ser 
1               5                   10                  15      


Gly Gly Asn Val Ile Leu Gln Cys Asp Ser Gln Val Ala Phe Asp Gly 
            20                  25                  30          


Phe Ser Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu Asn 
        35                  40                  45              


Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val Gly 
    50                  55                  60                  


Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp 
65                  70                  75                  80  


Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu Leu Glu Leu 
                85                  90                  95      


Leu Val Leu Gly Val 
            100     


