                         SEQUENCE LISTING

<110>  Beijing Advaccine Biotechnology Co.
 
<120>  Immune Composition Comprising Respiratory Syncytial Virus (RSV) G
        Polypeptide

<130>  104495-662605-70000WO00

<150>  62/885,370
<151>  2019-08-12

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Truncated form of a wild-type RSV G protein

<400>  1

His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr Ser Gln 
1               5                   10                  15      


Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln Leu Gly 
            20                  25                  30          


Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr Thr Ile 
        35                  40                  45              


Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro Thr Thr 
    50                  55                  60                  


Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser Lys Pro 
65                  70                  75                  80  


Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn Asp 
                85                  90                  95      


Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser Asn 
            100                 105                 110         


Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys Pro 
        115                 120                 125             


Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe Lys Thr 
    130                 135                 140                 


Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu Val Pro 
145                 150                 155                 160 


Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys Thr Asn 
                165                 170                 175     


Ile Thr Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro Lys Leu 
            180                 185                 190         


Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly Asn Leu 
        195                 200                 205             


Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln Pro Ser 
    210                 215                 220                 


Ser Pro Pro Asn Thr Thr Arg Gln 
225                 230         


<210>  2
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Modified RSV G protein 1(2)

<400>  2

His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr Ser Gln 
1               5                   10                  15      


Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln Leu Gly 
            20                  25                  30          


Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr Thr Ile 
        35                  40                  45              


Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro Thr Thr 
    50                  55                  60                  


Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser Lys Pro 
65                  70                  75                  80  


Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn Asn Asp 
                85                  90                  95      


Ser His Ser Glu Val Ser Asn Ser Val Pro Ser Ser Ile Cys Ser Asn 
            100                 105                 110         


Asn Pro Thr Cys Trp Ala Ile Ser Lys Arg Ile Pro Asn Lys Lys Pro 
        115                 120                 125             


Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe Lys Thr 
    130                 135                 140                 


Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu Val Pro 
145                 150                 155                 160 


Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys Thr Asn 
                165                 170                 175     


Ile Thr Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro Lys Leu 
            180                 185                 190         


Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly Asn Leu 
        195                 200                 205             


Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln Pro Ser 
    210                 215                 220                 


Ser Pro Pro Asn Thr Thr Arg Gln 
225                 230         


<210>  3
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Modified RSV G protein 3

<400>  3

His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr Ser Gln 
1               5                   10                  15      


Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln Leu Gly 
            20                  25                  30          


Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr Thr Ile 
        35                  40                  45              


Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro Thr Thr 
    50                  55                  60                  


Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser Lys Pro 
65                  70                  75                  80  


Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Lys Lys Pro Lys Asp Asp 
                85                  90                  95      


Tyr His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Gly Asn 
            100                 105                 110         


Asn Gln Leu Cys Lys Ser Ile Cys Lys Thr Ile Pro Ser Asn Lys Pro 
        115                 120                 125             


Lys Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe Lys Thr 
    130                 135                 140                 


Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu Val Pro 
145                 150                 155                 160 


Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys Thr Asn 
                165                 170                 175     


Ile Thr Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro Lys Leu 
            180                 185                 190         


Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly Asn Leu 
        195                 200                 205             


Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln Pro Ser 
    210                 215                 220                 


Ser Pro Pro Asn Thr Thr Arg Gln 
225                 230         


<210>  4
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Modified RSV G protein 4

<400>  4

His Lys Val Thr Pro Thr Thr Ala Ile Ile Gln Asp Ala Thr Ser Gln 
1               5                   10                  15      


Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asn Pro Gln Leu Gly 
            20                  25                  30          


Ile Ser Pro Ser Asn Pro Ser Glu Ile Thr Ser Gln Ile Thr Thr Ile 
        35                  40                  45              


Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Thr Leu Gln Ser Thr Thr 
    50                  55                  60                  


Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser Lys Pro 
65                  70                  75                  80  


Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Ser Lys Pro Asn Asn Asp 
                85                  90                  95      


Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys Ser Asn 
            100                 105                 110         


Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys Lys Pro 
        115                 120                 125             


Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Leu Lys Thr 
    130                 135                 140                 


Thr Lys Lys Asp Pro Lys Pro Gln Thr Thr Lys Ser Lys Glu Val Pro 
145                 150                 155                 160 


Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys Thr Asn 
                165                 170                 175     


Ile Ile Thr Thr Leu Leu Thr Ser Asn Thr Thr Gly Asn Pro Glu Leu 
            180                 185                 190         


Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly Asn Pro 
        195                 200                 205             


Ser Pro Ser Gln Val Ser Thr Thr Ser Glu Tyr Pro Ser Gln Pro Ser 
    210                 215                 220                 


Ser Pro Pro Asn Thr Pro Arg Gln 
225                 230         


<210>  5
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Modified RSV G protein 1(2)

<400>  5
cataaggtga ccctgactac tgctatcatc caggacgcaa ctagccaaat caaaaacacc       60

acgccgacct acctgactca ggatcctcag ctgggtatca gcttcagcaa cctgtctgag      120

atcacttctc agactacgac gatcctggcc tctaccactc caggtgtaaa atccaacctg      180

cagccaacca ccgtgaaaac caaaaatacc actaccaccc agacccagcc gtctaaacca      240

actacgaaac agcgtcagaa caaaccgcct aacaaaccaa acaacgactc ccactccgag      300

gtctctaact ccgttccgtc ctctatctgt tctaacaacc cgacttgctg ggcgatttct      360

aaacgcattc cgaacaagaa acctggtaaa aagaccacca cgaaaccgac gaaaaagccg      420

accttcaaaa ccaccaagaa agatctgaaa ccgcagacca ctaaaccgaa agaagttccg      480

acgaccaaac cgaccgaaga accgaccatt aataccacca aaaccaacat taccaccact      540

ctgctgacga acaacaccac tggcaacccg aaactgacct cccagatgga aacctttcac      600

agcacctcca gcgaaggcaa tctgtccccg tcccaggtta gcaccactag cgaacacccg      660

agccaaccgt cttctccgcc gaacactact cgtcaa                                696


<210>  6
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Modified RSV G protein 1(2)

<400>  6
cacaaagtca cactaacaac tgcaatcata caagatgcaa caagccagat caagaacaca       60

accccaacat acctcactca ggatcctcag cttggaatca gcttctccaa tctgtctgaa      120

attacatcac aaaccaccac catactagct tcaacaacac caggagtcaa gtcaaacctg      180

caacccacaa cagtcaagac taaaaacaca acaacaaccc aaacacaacc cagcaagccc      240

actacaaaac aacgccaaaa caaaccacca aacaaaccca ataatgatag tcacagtgaa      300

gtgagtaaca gtgtacccag tagcatatgc agcaacaatc caacctgctg ggctatcagt      360

aaaagaatac caaacaaaaa accaggaaag aaaaccacca ccaagcctac aaaaaaacca      420

accttcaaga caaccaaaaa agatctcaaa cctcaaacca ctaaaccaaa ggaagtaccc      480

accaccaagc ccacagaaga gccaaccatc aacaccacca aaacaaacat cacaactaca      540

ctgctcacca acaacaccac aggaaatcca aaactcacaa gtcaaatgga aaccttccac      600

tcaacctcct ccgaaggcaa tctaagccct tctcaagtct ccacaacatc cgagcaccca      660

tcacaaccct catctccacc caacacaaca cgccagtag                             699


<210>  7
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Modified RSV G protein 3

<400>  7
cacaaagtca cactaacaac tgcaatcata caagatgcaa caagccagat caagaacaca       60

accccaacat acctcactca ggatcctcag cttggaatca gcttctccaa tctgtctgaa      120

attacatcac aaaccaccac catactagct tcaacaacac caggagtcaa gtcaaacctg      180

caacccacaa cagtcaagac taaaaacaca acaacaaccc aaacacaacc cagcaagccc      240

actacaaaac aacgccaaaa caaaccacca aacaaaccca ataatgattt tcacttcgaa      300

gtgtttaact ttgtaccctg cagcatatgc agcaacaatc caacctgctg ggctatctgc      360

aaaagaatac caaacaaaaa accaggaaag aaaaccacca ccaagcctac aaaaaaacca      420

accttcaaga caaccaaaaa agatctcaaa cctcaaacca ctaaaccaaa ggaagtaccc      480

accaccaagc ccacagaaga gccaaccatc aacaccacca aaacaaacat cacaactaca      540

ctgctcacca acaacaccac aggaaatcca aaactcacaa gtcaaatgga aaccttccac      600

tcaacctcct ccgaaggcaa tctaagccct tctcaagtct ccacaacatc cgagcaccca      660

tcacaaccct catctccacc caacacaaca cgccagtag                             699


<210>  8
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Modified RSV G protein 4

<400>  8
cataaagtaa ccccgaccac cgctatcatc caggacgcta ccagccagat caaaaacact       60

acgcctacct atctgactca gaacccgcaa ctgggcatct ccccgtccaa tccgtctgaa      120

attacctccc agatcactac catcctggca tccactactc cgggtgtgaa atctaccctg      180

cagtccacta ccgtaaaaac gaaaaacacc accactaccc agactcagcc ttccaaacct      240

actacgaaac agcgtcagaa caaaccgccg agcaaaccga acaacgactt ccactttgaa      300

gttttcaact tcgtcccatg cagcatttgt agcaacaatc cgacctgctg ggcaatttgc      360

aaacgcatcc caaacaaaaa gccgggcaaa aagacgacca ctaaaccaac caagaaacct      420

accctgaaaa ctaccaaaaa agacccgaaa ccgcagacca ccaaatctaa agaagttccg      480

acgaccaaac cgaccgagga accgacgatc aacaccacga aaacgaacat catcaccacc      540

ctgctgacct ctaacactac cggtaatccg gagctgacta gccagatgga aacctttcac      600

agcacttctt ctgaaggtaa cccatctccg agccaggtgt ccaccacttc tgaatacccg      660

agccaaccgt cctccccgcc taatacgccg cgtcaa                                696


<210>  9
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Wild-type RSV G protein

<400>  9

Met Ser Lys Asn Lys Asp Gln Arg Thr Ala Lys Thr Leu Glu Lys Thr 
1               5                   10                  15      


Trp Asp Thr Leu Asn Tyr Leu Leu Phe Ile Ser Ser Gly Leu Tyr Lys 
            20                  25                  30          


Leu Asn Leu Lys Ser Ile Ala Gln Ile Thr Leu Ser Ile Leu Ala Met 
        35                  40                  45              


Ile Ile Ser Thr Ser Leu Ile Ile Thr Ala Ile Ile Phe Ile Ala Ser 
    50                  55                  60                  


Ala Asn His Lys Val Thr Leu Thr Thr Ala Ile Ile Gln Asp Ala Thr 
65                  70                  75                  80  


Ser Gln Ile Lys Asn Thr Thr Pro Thr Tyr Leu Thr Gln Asp Pro Gln 
                85                  90                  95      


Leu Gly Ile Ser Phe Ser Asn Leu Ser Glu Ile Thr Ser Gln Thr Thr 
            100                 105                 110         


Thr Ile Leu Ala Ser Thr Thr Pro Gly Val Lys Ser Asn Leu Gln Pro 
        115                 120                 125             


Thr Thr Val Lys Thr Lys Asn Thr Thr Thr Thr Gln Thr Gln Pro Ser 
    130                 135                 140                 


Lys Pro Thr Thr Lys Gln Arg Gln Asn Lys Pro Pro Asn Lys Pro Asn 
145                 150                 155                 160 


Asn Asp Phe His Phe Glu Val Phe Asn Phe Val Pro Cys Ser Ile Cys 
                165                 170                 175     


Ser Asn Asn Pro Thr Cys Trp Ala Ile Cys Lys Arg Ile Pro Asn Lys 
            180                 185                 190         


Lys Pro Gly Lys Lys Thr Thr Thr Lys Pro Thr Lys Lys Pro Thr Phe 
        195                 200                 205             


Lys Thr Thr Lys Lys Asp Leu Lys Pro Gln Thr Thr Lys Pro Lys Glu 
    210                 215                 220                 


Val Pro Thr Thr Lys Pro Thr Glu Glu Pro Thr Ile Asn Thr Thr Lys 
225                 230                 235                 240 


Thr Asn Ile Thr Thr Thr Leu Leu Thr Asn Asn Thr Thr Gly Asn Pro 
                245                 250                 255     


Lys Leu Thr Ser Gln Met Glu Thr Phe His Ser Thr Ser Ser Glu Gly 
            260                 265                 270         


Asn Leu Ser Pro Ser Gln Val Ser Thr Thr Ser Glu His Pro Ser Gln 
        275                 280                 285             


Pro Ser Ser Pro Pro Asn Thr Thr Arg Gln 
    290                 295             


