               SEQUENCE LISTING

<110> Boehringer Ingelheim RCV GmbH & Co KG

<120> CASPASE-2 VARIANTS

<130> BI002P

<140> PCT/EP2020/072934
<141> 2020-08-14

<160> 300

<170> BiSSAP 1.3.6

<210> 1
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 1
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 2
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> ss propeptide

<220> 
<221> SITE
<222> 14..14
<223> X can be any amino acid except D or E

<400> 2
Gly Lys Asn His Ala Gly Ser Pro Gly Cys Glu Glu Ser Xaa 
1               5                   10                  

<210> 3
<211> 105
<212> PRT
<213> Homo sapiens


<400> 3
Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser 
        35                  40                  45              
Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly His Pro Pro Thr 
            100                 105 

<210> 4
<211> 157
<212> PRT
<213> Homo sapiens


<400> 4
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Gly Phe Tyr Gln 
1               5                   10                  15      
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
        35                  40                  45              
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
    50                  55                  60                  
Lys Leu Leu Gly Tyr Asp Val Arg Val Leu Cys Asp Gln Thr Ala Gln 
65                  70                  75                  80  
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
                85                  90                  95      
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
            100                 105                 110         
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
        115                 120                 125             
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
    130                 135                 140                 
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp 
145                 150                 155         

<210> 5
<211> 7
<212> PRT
<213> Homo sapiens


<400> 5
Arg Gly Val Asp Gln Gln Asp 
1               5           

<210> 6
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 6
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 7
<211> 879
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 7
atgcaccatc atcaccatca tggcaaaaat catgcaggta gtccgggttg tgaagaaagc      60

gcagcaggta aagaaaaact gccgaaaatg cgtctgccga cccgtagcga tatgatttgt     120

ggttatgcat gtctgaaagg caccgcagca atgcgtaata ccaaacgtgg tagctggtat     180

attgaagcac tggcacaggt ttttagcgaa cgtgcatgtg atatgcatgt tgcagatatg     240

ctggttaaag tgaacgccct gattaaagat cgtgaaggtt atgcaccggg tacagaattt     300

catcgttgta aagaaatgag cgagtattgt agcaccctgt gtcgtcatct gtacctgttt     360

ccgggtcatc ctccgaccgg atccggtccg gtttgtctgc aggttaaacc gtgtacaccg     420

gaattttatc agacccattt tcagctggca tatcgtctgc agagccgtcc gcgtggtctg     480

gcactggttc tgagcaatgt tcattttacc ggtgaaaaag aactggaatt tcgtagcggt     540

ggtgatgttg atcatagtac cctggttacc ctgtttaaac tgctgggtta tgacgttcat     600

gttctgtgtg atcagaccgc acaagaaatg caagagaaac tgcagaattt tgcacagctg     660

cctgcacatc gtgttaccga tagctgtatt gttgcactgc tgagccatgg tgttgaaggt     720

gcaatttatg gtgtggatgg caaactgctg caactgcaag aagtgtttca gctgtttgat     780

aatgcaaatt gtccgagcct gcagaataaa ccgaaaatgt tttttatcca ggcctgccgt     840

ggtgatgaaa ccgatcgtgg tgttgatcag caggattaa                            879


<210> 8
<211> 858
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 8
atgggcaaaa atcatgcagg tagtccgggt tgtgaagaaa gcgcagcagg taaagaaaaa      60

ctgccgaaaa tgcgtctgcc gacccgtagc gatatgattt gtggttatgc atgtctgaaa     120

ggcaccgcag caatgcgtaa taccaaacgt ggtagctggt atattgaagc actggcacag     180

gtttttagcg aacgtgcatg tgatatgcat gttgcagata tgctggttaa agtgaacgcc     240

ctgattaaag atcgtgaagg ttatgcaccg ggtacagaat ttcatcgttg taaagaaatg     300

agcgagtatt gtagcaccct gtgtcgtcat ctgtacctgt ttccgggtca tcctccgacc     360

ggatccggtc cggtttgtct gcaggttaaa ccgtgtacac cggaatttta tcagacccat     420

tttcagctgg catatcgtct gcagagccgt ccgcgtggtc tggcactggt tctgagcaat     480

gttcatttta ccggtgaaaa agaactggaa tttcgtagcg gtggtgatgt tgatcatagt     540

accctggtta ccctgtttaa actgctgggt tatgacgttc atgttctgtg tgatcagacc     600

gcacaagaaa tgcaagagaa actgcagaat tttgcacagc tgcctgcaca tcgtgttacc     660

gatagctgta ttgttgcact gctgagccat ggtgttgaag gtgcaattta tggtgtggat     720

ggcaaactgc tgcaactgca agaagtgttt cagctgtttg ataatgcaaa ttgtccgagc     780

ctgcagaata aaccgaaaat gttttttatc caggcctgcc gtggtgatga aaccgatcgt     840

ggtgttgatc agcaggat                                                   858


<210> 9
<211> 286
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 9
Met Gly Lys Asn His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala 
1               5                   10                  15      
Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met 
            20                  25                  30          
Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr 
        35                  40                  45              
Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu 
    50                  55                  60                  
Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn Ala 
65                  70                  75                  80  
Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg 
                85                  90                  95      
Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr 
            100                 105                 110         
Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln 
        115                 120                 125             
Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala 
    130                 135                 140                 
Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn 
145                 150                 155                 160 
Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp 
                165                 170                 175     
Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp 
            180                 185                 190         
Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu 
        195                 200                 205             
Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile 
    210                 215                 220                 
Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp 
225                 230                 235                 240 
Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala 
                245                 250                 255     
Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala 
            260                 265                 270         
Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
        275                 280                 285     

<210> 10
<211> 1308
<212> DNA
<213> Homo sapiens


<400> 10
atggccgctg acaggggacg caggatattg ggagtgtgtg gcatgcatcc tcatcatcag      60

gaaactctaa aaaagaaccg agtggtgcta gccaaacagc tgttgttgag cgaattgtta     120

gaacatcttc tggagaagga catcatcacc ttggaaatga gggagctcat ccaggccaaa     180

gtgggcagtt tcagccagaa tgtggaactc ctcaacttgc tgcctaagag gggtccccaa     240

gcttttgatg ccttctgtga agcactgagg gagaccaagc aaggccacct ggaggatatg     300

ttgctcacca ccctttctgg gcttcagcat gtactcccac cgttgagctg tgactacgac     360

ttgagtctcc cttttccggt gtgtgagtcc tgtccccttt acaagaagct ccgcctgtcg     420

acagatactg tggaacactc cctagacaat aaagatggtc ctgtctgcct tcaggtgaag     480

ccttgcactc ctgaatttta tcaaacacac ttccagctgg catataggtt gcagtctcgg     540

cctcgtggcc tagcactggt gttgagcaat gtgcacttca ctggagagaa agaactggaa     600

tttcgctctg gaggggatgt ggaccacagt actctagtca ccctcttcaa gcttttgggc     660

tatgacgtcc atgttctatg tgaccagact gcacaggaaa tgcaagagaa actgcagaat     720

tttgcacagt tacctgcaca ccgagtcacg gactcctgca tcgtggcact cctctcgcat     780

ggtgtggagg gcgccatcta tggtgtggat gggaaactgc tccagctcca agaggttttt     840

cagctctttg acaacgccaa ctgcccaagc ctacagaaca aaccaaaaat gttcttcatc     900

caggcctgcc gtggagatga gactgatcgt ggggttgacc aacaagatgg aaagaaccac     960

gcaggatccc ctgggtgcga ggagagtgat gccggtaaag aaaagttgcc gaagatgaga    1020

ctgcccacgc gctcagacat gatatgcggc tatgcctgcc tcaaagggac tgccgccatg    1080

cggaacacca aacgaggttc ctggtacatc gaggctcttg ctcaagtgtt ttctgagcgg    1140

gcttgtgata tgcacgtggc cgacatgctg gttaaggtga acgcacttat caaggatcgg    1200

gaaggttatg ctcctggcac agaattccac cggtgcaagg aaatgtctga atactgcagc    1260

actctgtgcc gccacctcta cctgttccca ggacaccctc ccacatga                 1308


<210> 11
<211> 452
<212> PRT
<213> Homo sapiens


<400> 11
Met Ala Ala Pro Ser Ala Gly Ser Trp Ser Thr Phe Gln His Lys Glu 
1               5                   10                  15      
Leu Met Ala Ala Asp Arg Gly Arg Arg Ile Leu Gly Val Cys Gly Met 
            20                  25                  30          
His Pro His His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              
Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  
Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Val Gly Ser 
65                  70                  75                  80  
Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      
Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Lys Gln Gly 
            100                 105                 110         
His Leu Glu Asp Met Leu Leu Thr Thr Leu Ser Gly Leu Gln His Val 
        115                 120                 125             
Leu Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 
Cys Glu Ser Cys Pro Leu Tyr Lys Lys Leu Arg Leu Ser Thr Asp Thr 
145                 150                 155                 160 
Val Glu His Ser Leu Asp Asn Lys Asp Gly Pro Val Cys Leu Gln Val 
                165                 170                 175     
Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
            180                 185                 190         
Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
        195                 200                 205             
His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
    210                 215                 220                 
Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
225                 230                 235                 240 
His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
                245                 250                 255     
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
            260                 265                 270         
Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
        275                 280                 285             
Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
    290                 295                 300                 
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
305                 310                 315                 320 
Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                325                 330                 335     
His Ala Gly Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Lys 
            340                 345                 350         
Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
        355                 360                 365             
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
    370                 375                 380                 
Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
385                 390                 395                 400 
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
                405                 410                 415     
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
            420                 425                 430         
Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
        435                 440                 445             
His Pro Pro Thr 
    450         

<210> 12
<211> 879
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 12
atgcaccatc atcaccatca tggcaaaaat catgcaggta gtccgggttg tgaagaaagc      60

gcagcaggta aagaaaaact gccgaaaatg cgtctgccga cccgtagcga tatgatttgt     120

ggttatgcat gtctgaaagg caccgcagca atgcgtaata ccaaacgtgg tagctggtat     180

attgaagcac tggcacaggt ttttagcgaa cgtgcatgtg atatgcatgt tgcagatatg     240

ctggttaaag tgaacgccct gattaaagat cgtgaaggtt atgcaccggg tacagaattt     300

catcgttgta aagaaatgag cgagtattgt agcaccctgt gtcgtcatct gtacctgttt     360

ccgggtcatc ctccgaccgg atccggtccg gtttgtctgc aggttaaacc gtgtacaccg     420

gaattttatc agacccattt tcagctggca tatcgtctgc agagccgtcc gcgtggtctg     480

gcactggttc tgagcaatgt tcattttacc ggtgaaaaag aactggaatt tcgtagcggt     540

ggtgatgttg atcatagtac cctggttacc ctgtttaaac tgctgggtta tgacgttcat     600

gttctgtgtg atcagaccgc acaagaaatg caagagaaac tgcagaattt tgcacagctg     660

cctgcacatc gtgttaccga tagctgtatt gttgcactgc tgagccatgg tgttgaaggt     720

gcaatttatg gtgtggatgg caaactgctg caactgcaag aagtgtttca gctgtttgat     780

aatgcaaatt gtccgagcct gcagaataaa ccgaaaatgt tttttatcca ggcctgccgt     840

ggtgatgaaa ccgagcgtgg tgttgatcag caggattaa                            879


<210> 13
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 13
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 14
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 14
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp 
        275                 280                 285 

<210> 15
<211> 303
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 15
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Ser Gly Ser Gly Trp Ser His Pro Gln Phe Glu Lys 
    290                 295                 300             

<210> 16
<211> 303
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 16
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Ser Gly Ser Gly Trp Ser His Pro Gln Phe Glu Lys 
    290                 295                 300             

<210> 17
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase

<400> 17
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 18
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 18
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp Ala Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 19
<211> 185
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 19
Met Arg Gly Ser His His His His His His Gly Ser Gly Val Asp Thr 
1               5                   10                  15      
Thr Asp Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met 
            20                  25                  30          
Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
        35                  40                  45              
Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
    50                  55                  60                  
Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
65                  70                  75                  80  
Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
                85                  90                  95      
Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
            100                 105                 110         
Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
        115                 120                 125             
Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
    130                 135                 140                 
Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
145                 150                 155                 160 
Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
                165                 170                 175     
Lys Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 185 

<210> 20
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> MCSI (pyrI D73E)

<400> 20
Met Gly Thr His Asp Asn Lys Leu Gln Val Glu Ala Ile Lys Arg Gly 
1               5                   10                  15      
Thr Val Ile Asp His Ile Pro Ala Gln Ile Gly Phe Lys Leu Leu Ser 
            20                  25                  30          
Leu Phe Lys Leu Thr Glu Thr Asp Gln Arg Ile Thr Ile Gly Leu Asn 
        35                  40                  45              
Leu Pro Ser Gly Glu Met Gly Arg Lys Asp Leu Ile Lys Ile Glu Asn 
    50                  55                  60                  
Thr Phe Leu Ser Glu Asp Gln Val Glu Gln Leu Ala Leu Tyr Ala Pro 
65                  70                  75                  80  
Gln Ala Thr Val Asn Arg Ile Asp Asn Tyr Glu Val Val Gly Lys Ser 
                85                  90                  95      
Arg Pro Ser Leu Pro Glu Arg Ile Asp Asn Val Leu Val Cys Pro Asn 
            100                 105                 110         
Ser Asn Cys Ile Ser His Ala Glu Pro Val Ser Ser Ser Phe Ala Val 
        115                 120                 125             
Arg Lys Arg Ala Asn Asp Ile Ala Leu Lys Cys Lys Tyr Cys Glu Lys 
    130                 135                 140                 
Glu Phe Ser His Asn Val Val Leu Ala Asn 
145                 150                 

<210> 21
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> MCSII (cp pyrB)

<400> 21
Met Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn 
1               5                   10                  15      
Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys 
            20                  25                  30          
Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala 
        35                  40                  45              
Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly 
    50                  55                  60                  
Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg 
65                  70                  75                  80  
Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser 
                85                  90                  95      
Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala 
            100                 105                 110         
Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe 
        115                 120                 125             
Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His 
    130                 135                 140                 
Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser 
145                 150                 155                 160 
Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser 
                165                 170                 175     
Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala 
            180                 185                 190         
Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly 
        195                 200                 205             
Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr 
    210                 215                 220                 
Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val 
225                 230                 235                 240 
Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu 
                245                 250                 255     
Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu 
            260                 265                 270         
Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala 
        275                 280                 285             
Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile 
    290                 295                 300                 
Leu Tyr 
305     

<210> 22
<211> 320
<212> PRT
<213> Artificial Sequence


<220> 
<223> cp ATCase

<220> 
<221> SITE
<222> 16..16
<223> X can be any amino acid

<400> 22
Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Xaa 
1               5                   10                  15      
Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys 
            20                  25                  30          
Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn 
        35                  40                  45              
Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp 
    50                  55                  60                  
Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly 
65                  70                  75                  80  
Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn 
                85                  90                  95      
Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp 
            100                 105                 110         
Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro 
        115                 120                 125             
Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu 
    130                 135                 140                 
Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu 
145                 150                 155                 160 
Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly 
                165                 170                 175     
Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr 
            180                 185                 190         
Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu 
        195                 200                 205             
Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly 
    210                 215                 220                 
Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln 
225                 230                 235                 240 
Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp 
                245                 250                 255     
Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys 
            260                 265                 270         
Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met 
        275                 280                 285             
Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser 
    290                 295                 300                 
Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 320 



<210> 23
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 23
Gly Lys Asn His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly 
1               5                   10                  15      
Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile 
            20                  25                  30          
Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys 
        35                  40                  45              
Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg 
    50                  55                  60                  
Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu 
65                  70                  75                  80  
Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys 
                85                  90                  95      
Lys Val Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu 
            100                 105                 110         
Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Arg Leu Gln Val 
        115                 120                 125             
Lys Pro Cys Thr Pro Gly Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
    130                 135                 140                 
Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
145                 150                 155                 160 
His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
                165                 170                 175     
Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
            180                 185                 190         
Arg Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
        195                 200                 205             
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
    210                 215                 220                 
Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
225                 230                 235                 240 
Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
                245                 250                 255     
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
            260                 265                 270         
Arg Gly Asp Glu Thr Glu Arg Gly Val Asp Gln Gln Asp 
        275                 280                 285 

<210> 24
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 24
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Arg Leu Gln Val Lys Pro Cys Thr Pro Gly Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val Arg Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 25
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 25
Gly Lys Asn His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly 
1               5                   10                  15      
Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile 
            20                  25                  30          
Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys 
        35                  40                  45              
Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg 
    50                  55                  60                  
Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu 
65                  70                  75                  80  
Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys 
                85                  90                  95      
Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu 
            100                 105                 110         
Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val 
        115                 120                 125             
Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
    130                 135                 140                 
Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
145                 150                 155                 160 
His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
                165                 170                 175     
Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
            180                 185                 190         
His Val Leu Tyr Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
        195                 200                 205             
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
    210                 215                 220                 
Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
225                 230                 235                 240 
Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
                245                 250                 255     
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
            260                 265                 270         
Arg Gly Asp Glu Thr Glu Arg Gly Val Asp Gln Gln Asp 
        275                 280                 285 

<210> 26
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 26
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Tyr Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 27
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 27
Gly Lys Asn His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly 
1               5                   10                  15      
Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile 
            20                  25                  30          
Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys 
        35                  40                  45              
Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg 
    50                  55                  60                  
Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu 
65                  70                  75                  80  
Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys 
                85                  90                  95      
Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu 
            100                 105                 110         
Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val 
        115                 120                 125             
Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
    130                 135                 140                 
Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
145                 150                 155                 160 
His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val 
                165                 170                 175     
Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
            180                 185                 190         
His Ala Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
        195                 200                 205             
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
    210                 215                 220                 
Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
225                 230                 235                 240 
Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
                245                 250                 255     
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
            260                 265                 270         
Arg Gly Asp Glu Thr Glu Arg Gly Val Asp Gln Gln Asp 
        275                 280                 285 

<210> 28
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 28
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Ala Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 29
<211> 285
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 29
Gly Lys Asn His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly 
1               5                   10                  15      
Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile 
            20                  25                  30          
Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys 
        35                  40                  45              
Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg 
    50                  55                  60                  
Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu 
65                  70                  75                  80  
Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys 
                85                  90                  95      
Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu 
            100                 105                 110         
Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val 
        115                 120                 125             
Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr 
    130                 135                 140                 
Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
145                 150                 155                 160 
His Phe Thr Gly Glu Lys Gly Leu Glu Phe Arg Ser Gly Gly Asp Val 
                165                 170                 175     
Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val 
            180                 185                 190         
His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
        195                 200                 205             
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val 
    210                 215                 220                 
Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
225                 230                 235                 240 
Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn 
                245                 250                 255     
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
            260                 265                 270         
Arg Gly Asp Glu Thr Glu Arg Gly Val Asp Gln Gln Asp 
        275                 280                 285 

<210> 30
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 30
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Gly Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 31
<211> 510
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 31
atgcaccatc accatcacca tggcagcggc gtggatgtgg cggatgccgc tggttcgatt      60

actaccctgc ctgctttacc tgaagatggt ggttctggtg cgttcccgcc gggtcacttc     120

aaagacccaa aacgtttgta ctgtaaaaac ggtggctttt ttctgcgcat ccatccggac     180

ggccgcgtgg atggtgtccg tgaaaagtcc gacccgcaca ttaagctgca actgcaggcc     240

gaggagcgtg gtgttgttag catcaaaggc gtgagcgcaa atcgttacct ggcgatgaaa     300

gaggatggcc gtctgctggc gagcaagagc gttaccgacg agtgcttctt ctttgaacgc     360

ctggagagca ataattacaa cacctaccgt agccgcaagt atacctcttg gtatgtggcg     420

ctgaagcgta cgggccagta taaattgggt agcaaaacgg gtccgggcca aaaggcaatc     480

ctgttcctgc cgatgagcgc gaaatcctaa                                      510


<210> 32
<211> 169
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 32
Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Ala 
1               5                   10                  15      
Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly Gly Ser 
            20                  25                  30          
Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr Cys 
        35                  40                  45              
Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp 
    50                  55                  60                  
Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala 
65                  70                  75                  80  
Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Ser Ala Asn Arg Tyr 
                85                  90                  95      
Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Ser Val Thr 
            100                 105                 110         
Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr 
        115                 120                 125             
Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr 
    130                 135                 140                 
Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile 
145                 150                 155                 160 
Leu Phe Leu Pro Met Ser Ala Lys Ser 
                165                 

<210> 33
<211> 185
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 33
Met Arg Gly Ser His His His His His His Gly Ser Gly Val Asp Val 
1               5                   10                  15      
Ala Asp Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met 
            20                  25                  30          
Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
        35                  40                  45              
Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
    50                  55                  60                  
Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
65                  70                  75                  80  
Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
                85                  90                  95      
Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
            100                 105                 110         
Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
        115                 120                 125             
Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
    130                 135                 140                 
Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
145                 150                 155                 160 
Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
                165                 170                 175     
Lys Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 185 

<210> 34
<211> 1039
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 34
Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Met 
1               5                   10                  15      
Thr Met Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg Arg Asp Trp 
            20                  25                  30          
Glu Asn Pro Gly Val Thr Gln Leu Asn Arg Leu Ala Ala His Pro Pro 
        35                  40                  45              
Phe Ala Ser Trp Arg Asn Ser Glu Glu Ala Arg Thr Asp Arg Pro Ser 
    50                  55                  60                  
Gln Gln Leu Arg Ser Leu Asn Gly Glu Trp Arg Phe Ala Trp Phe Pro 
65                  70                  75                  80  
Ala Pro Glu Ala Val Pro Glu Ser Trp Leu Glu Cys Asp Leu Pro Glu 
                85                  90                  95      
Ala Asp Thr Val Val Val Pro Ser Asn Trp Gln Met His Gly Tyr Asp 
            100                 105                 110         
Ala Pro Ile Tyr Thr Asn Val Thr Tyr Pro Ile Thr Val Asn Pro Pro 
        115                 120                 125             
Phe Val Pro Thr Glu Asn Pro Thr Gly Cys Tyr Ser Leu Thr Phe Asn 
    130                 135                 140                 
Val Asp Glu Ser Trp Leu Gln Glu Gly Gln Thr Arg Ile Ile Phe Asp 
145                 150                 155                 160 
Gly Val Asn Ser Ala Phe His Leu Trp Cys Asn Gly Arg Trp Val Gly 
                165                 170                 175     
Tyr Gly Gln Asp Ser Arg Leu Pro Ser Glu Phe Asp Leu Ser Ala Phe 
            180                 185                 190         
Leu Arg Ala Gly Glu Asn Arg Leu Ala Val Met Val Leu Arg Trp Ser 
        195                 200                 205             
Asp Gly Ser Tyr Leu Glu Asp Gln Asp Met Trp Arg Met Ser Gly Ile 
    210                 215                 220                 
Phe Arg Asp Val Ser Leu Leu His Lys Pro Thr Thr Gln Ile Ser Asp 
225                 230                 235                 240 
Phe His Val Ala Thr Arg Phe Asn Asp Asp Phe Ser Arg Ala Val Leu 
                245                 250                 255     
Glu Ala Glu Val Gln Met Cys Gly Glu Leu Arg Asp Tyr Leu Arg Val 
            260                 265                 270         
Thr Val Ser Leu Trp Gln Gly Glu Thr Gln Val Ala Ser Gly Thr Ala 
        275                 280                 285             
Pro Phe Gly Gly Glu Ile Ile Asp Glu Arg Gly Gly Tyr Ala Asp Arg 
    290                 295                 300                 
Val Thr Leu Arg Leu Asn Val Glu Asn Pro Lys Leu Trp Ser Ala Glu 
305                 310                 315                 320 
Ile Pro Asn Leu Tyr Arg Ala Val Val Glu Leu His Thr Ala Asp Gly 
                325                 330                 335     
Thr Leu Ile Glu Ala Glu Ala Cys Asp Val Gly Phe Arg Glu Val Arg 
            340                 345                 350         
Ile Glu Asn Gly Leu Leu Leu Leu Asn Gly Lys Pro Leu Leu Ile Arg 
        355                 360                 365             
Gly Val Asn Arg His Glu His His Pro Leu His Gly Gln Val Met Asp 
    370                 375                 380                 
Glu Gln Thr Met Val Gln Asp Ile Leu Leu Met Lys Gln Asn Asn Phe 
385                 390                 395                 400 
Asn Ala Val Arg Cys Ser His Tyr Pro Asn His Pro Leu Trp Tyr Thr 
                405                 410                 415     
Leu Cys Asp Arg Tyr Gly Leu Tyr Val Val Asp Glu Ala Asn Ile Glu 
            420                 425                 430         
Thr His Gly Met Val Pro Met Asn Arg Leu Thr Asp Asp Pro Arg Trp 
        435                 440                 445             
Leu Pro Ala Met Ser Glu Arg Val Thr Arg Met Val Gln Arg Asp Arg 
    450                 455                 460                 
Asn His Pro Ser Val Ile Ile Trp Ser Leu Gly Asn Glu Ser Gly His 
465                 470                 475                 480 
Gly Ala Asn His Asp Ala Leu Tyr Arg Trp Ile Lys Ser Val Asp Pro 
                485                 490                 495     
Ser Arg Pro Val Gln Tyr Glu Gly Gly Gly Ala Asp Thr Thr Ala Thr 
            500                 505                 510         
Asp Ile Ile Cys Pro Met Tyr Ala Arg Val Asp Glu Asp Gln Pro Phe 
        515                 520                 525             
Pro Ala Val Pro Lys Trp Ser Ile Lys Lys Trp Leu Ser Leu Pro Gly 
    530                 535                 540                 
Glu Thr Arg Pro Leu Ile Leu Cys Glu Tyr Ala His Ala Met Gly Asn 
545                 550                 555                 560 
Ser Leu Gly Gly Phe Ala Lys Tyr Trp Gln Ala Phe Arg Gln Tyr Pro 
                565                 570                 575     
Arg Leu Gln Gly Gly Phe Val Trp Asp Trp Val Asp Gln Ser Leu Ile 
            580                 585                 590         
Lys Tyr Asp Glu Asn Gly Asn Pro Trp Ser Ala Tyr Gly Gly Asp Phe 
        595                 600                 605             
Gly Asp Thr Pro Asn Asp Arg Gln Phe Cys Met Asn Gly Leu Val Phe 
    610                 615                 620                 
Ala Asp Arg Thr Pro His Pro Ala Leu Thr Glu Ala Lys His Gln Gln 
625                 630                 635                 640 
Gln Phe Phe Gln Phe Arg Leu Ser Gly Gln Thr Ile Glu Val Thr Ser 
                645                 650                 655     
Glu Tyr Leu Phe Arg His Ser Asp Asn Glu Leu Leu His Trp Met Val 
            660                 665                 670         
Ala Leu Asp Gly Lys Pro Leu Ala Ser Gly Glu Val Pro Leu Asp Val 
        675                 680                 685             
Ala Pro Gln Gly Lys Gln Leu Ile Glu Leu Pro Glu Leu Pro Gln Pro 
    690                 695                 700                 
Glu Ser Ala Gly Gln Leu Trp Leu Thr Val Arg Val Val Gln Pro Asn 
705                 710                 715                 720 
Ala Thr Ala Trp Ser Glu Ala Gly His Ile Ser Ala Trp Gln Gln Trp 
                725                 730                 735     
Arg Leu Ala Glu Asn Leu Ser Val Thr Leu Pro Ala Ala Ser His Ala 
            740                 745                 750         
Ile Pro His Leu Thr Thr Ser Glu Met Asp Phe Cys Ile Glu Leu Gly 
        755                 760                 765             
Asn Lys Arg Trp Gln Phe Asn Arg Gln Ser Gly Phe Leu Ser Gln Met 
    770                 775                 780                 
Trp Ile Gly Asp Lys Lys Gln Leu Leu Thr Pro Leu Arg Asp Gln Phe 
785                 790                 795                 800 
Thr Arg Ala Pro Leu Asp Asn Asp Ile Gly Val Ser Glu Ala Thr Arg 
                805                 810                 815     
Ile Asp Pro Asn Ala Trp Val Glu Arg Trp Lys Ala Ala Gly His Tyr 
            820                 825                 830         
Gln Ala Glu Ala Ala Leu Leu Gln Cys Thr Ala Asp Thr Leu Ala Asp 
        835                 840                 845             
Ala Val Leu Ile Thr Thr Ala His Ala Trp Gln His Gln Gly Lys Thr 
    850                 855                 860                 
Leu Phe Ile Ser Arg Lys Thr Tyr Arg Ile Asp Gly Ser Gly Gln Met 
865                 870                 875                 880 
Ala Ile Thr Val Asp Val Glu Val Ala Ser Asp Thr Pro His Pro Ala 
                885                 890                 895     
Arg Ile Gly Leu Asn Cys Gln Leu Ala Gln Val Ala Glu Arg Val Asn 
            900                 905                 910         
Trp Leu Gly Leu Gly Pro Gln Glu Asn Tyr Pro Asp Arg Leu Thr Ala 
        915                 920                 925             
Ala Cys Phe Asp Arg Trp Asp Leu Pro Leu Ser Asp Met Tyr Thr Pro 
    930                 935                 940                 
Tyr Val Phe Pro Ser Glu Asn Gly Leu Arg Cys Gly Thr Arg Glu Leu 
945                 950                 955                 960 
Asn Tyr Gly Pro His Gln Trp Arg Gly Asp Phe Gln Phe Asn Ile Ser 
                965                 970                 975     
Arg Tyr Ser Gln Gln Gln Leu Met Glu Thr Ser His Arg His Leu Leu 
            980                 985                 990         
His Ala Glu Glu Gly Thr Trp Leu Asn Ile Asp Gly Phe His Met Gly 
        995                 1000                1005            
Ile Gly Gly Asp Asp Ser Trp Ser Pro Ser Val Ser Ala Glu Phe Gln 
    1010                1015                1020                
Leu Ser Ala Gly Arg Tyr His Tyr Gln Leu Val Trp Cys Gln Lys 
1025                1030                1035                

<210> 35
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 35
Met His His His His His His Leu Glu Asp Pro Glu Arg Asn Lys Glu 
1               5                   10                  15      
Arg Lys Glu Ala Glu Leu Glu Ala Glu Thr Ala Glu Gln Gly Lys Asn 
            20                  25                  30          
His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
        115                 120                 125             
Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr 
            180                 185                 190         
Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu 
    210                 215                 220                 
Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala 
225                 230                 235                 240 
Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp 
    290                 295                 300                 
Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
305                 310                 

<210> 36
<211> 945
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 36
atgcaccatc atcaccatca tctggaggat ccggaacgca acaaagagcg aaaggaagct      60

gagttggaag ctgagaccgc tgagcaaggc aaaaatcatg caggtagtcc gggttgtgaa     120

gaaagcgcag caggtaaaga aaaactgccg aaaatgcgtc tgccgacccg tagcgatatg     180

atttgtggtt atgcatgtct gaaaggcacc gcagcaatgc gtaataccaa acgtggtagc     240

tggtatattg aagcactggc acaggttttt agcgaacgtg catgtgatat gcatgttgca     300

gatatgctgg ttaaagtgaa cgccctgatt aaagatcgtg aaggttatgc accgggtaca     360

gaatttcatc gttgtaaaga aatgagcgag tattgtagca ccctgtgtcg tcatctgtac     420

ctgtttccgg gtcatcctcc gaccggatcc ggtccggttt gtctgcaggt taaaccgtgt     480

acaccggaat tttatcagac ccattttcag ctggcatatc gtctgcagag ccgtccgcgt     540

ggtctggcac tggttctgag caatgttcat tttaccggtg aaaaagaact ggaatttcgt     600

agcggtggtg atgttgatca tagtaccctg gttaccctgt ttaaactgct gggttatgac     660

gttcatgttc tgtgtgatca gaccgcacaa gaaatgcaag agaaactgca gaattttgca     720

cagctgcctg cacatcgtgt taccgatagc tgtattgttg cactgctgag ccatggtgtt     780

gaaggtgcaa tttatggtgt ggatggcaaa ctgctgcaac tgcaagaagt gtttcagctg     840

tttgataatg caaattgtcc gagcctgcag aataaaccga aaatgttttt tatccaggcc     900

tgccgtggtg atgaaaccga tcgtggtgtt gatcagcagg attaa                     945


<210> 37
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> T7A3 tag

<400> 37
Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu Glu 
1               5                   10                  15      
Ala Glu Thr Ala Glu Gln 
            20          

<210> 38
<211> 66
<212> DNA
<213> Artificial Sequence


<220> 
<223> T7A3 tag

<400> 38
ctggaggatc cggaacgcaa caaagagcga aaggaagctg agttggaagc tgagaccgct     60

gagcaa                                                                66


<210> 39
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 39
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Glu Ala Glu Thr Ala Glu Gln His His His His His His Gly Lys Asn 
            20                  25                  30          
His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
        115                 120                 125             
Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr 
            180                 185                 190         
Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu 
    210                 215                 220                 
Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala 
225                 230                 235                 240 
Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp 
    290                 295                 300                 
Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
305                 310                 

<210> 40
<211> 945
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 40
atgctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgga agctgagacc      60

gctgagcaac accatcatca ccatcatggc aaaaatcatg caggtagtcc gggttgtgaa     120

gaaagcgcag caggtaaaga aaaactgccg aaaatgcgtc tgccgacccg tagcgatatg     180

atttgtggtt atgcatgtct gaaaggcacc gcagcaatgc gtaataccaa acgtggtagc     240

tggtatattg aagcactggc acaggttttt agcgaacgtg catgtgatat gcatgttgca     300

gatatgctgg ttaaagtgaa cgccctgatt aaagatcgtg aaggttatgc accgggtaca     360

gaatttcatc gttgtaaaga aatgagcgag tattgtagca ccctgtgtcg tcatctgtac     420

ctgtttccgg gtcatcctcc gaccggatcc ggtccggttt gtctgcaggt taaaccgtgt     480

acaccggaat tttatcagac ccattttcag ctggcatatc gtctgcagag ccgtccgcgt     540

ggtctggcac tggttctgag caatgttcat tttaccggtg aaaaagaact ggaatttcgt     600

agcggtggtg atgttgatca tagtaccctg gttaccctgt ttaaactgct gggttatgac     660

gttcatgttc tgtgtgatca gaccgcacaa gaaatgcaag agaaactgca gaattttgca     720

cagctgcctg cacatcgtgt taccgatagc tgtattgttg cactgctgag ccatggtgtt     780

gaaggtgcaa tttatggtgt ggatggcaaa ctgctgcaac tgcaagaagt gtttcagctg     840

tttgataatg caaattgtcc gagcctgcag aataaaccga aaatgttttt tatccaggcc     900

tgccgtggtg atgaaaccga tcgtggtgtt gatcagcagg attaa                     945


<210> 41
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 41
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Lys Asn 
            20                  25                  30          
His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
        115                 120                 125             
Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr 
            180                 185                 190         
Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu 
    210                 215                 220                 
Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala 
225                 230                 235                 240 
Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp 
    290                 295                 300                 
Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
305                 310                 

<210> 42
<211> 945
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 42
atgctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgca agctcaaacc      60

gctgagcaac accatcatca ccatcatggc aaaaatcatg caggtagtcc gggttgtgaa     120

gaaagcgcag caggtaaaga aaaactgccg aaaatgcgtc tgccgacccg tagcgatatg     180

atttgtggtt atgcatgtct gaaaggcacc gcagcaatgc gtaataccaa acgtggtagc     240

tggtatattg aagcactggc acaggttttt agcgaacgtg catgtgatat gcatgttgca     300

gatatgctgg ttaaagtgaa cgccctgatt aaagatcgtg aaggttatgc accgggtaca     360

gaatttcatc gttgtaaaga aatgagcgag tattgtagca ccctgtgtcg tcatctgtac     420

ctgtttccgg gtcatcctcc gaccggatcc ggtccggttt gtctgcaggt taaaccgtgt     480

acaccggaat tttatcagac ccattttcag ctggcatatc gtctgcagag ccgtccgcgt     540

ggtctggcac tggttctgag caatgttcat tttaccggtg aaaaagaact ggaatttcgt     600

agcggtggtg atgttgatca tagtaccctg gttaccctgt ttaaactgct gggttatgac     660

gttcatgttc tgtgtgatca gaccgcacaa gaaatgcaag agaaactgca gaattttgca     720

cagctgcctg cacatcgtgt taccgatagc tgtattgttg cactgctgag ccatggtgtt     780

gaaggtgcaa tttatggtgt ggatggcaaa ctgctgcaac tgcaagaagt gtttcagctg     840

tttgataatg caaattgtcc gagcctgcag aataaaccga aaatgttttt tatccaggcc     900

tgccgtggtg atgaaaccga tcgtggtgtt gatcagcagg attaa                     945


<210> 43
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> T7AC tag

<400> 43
Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu Gln 
1               5                   10                  15      
Ala Gln Thr Ala Glu Gln 
            20          

<210> 44
<211> 66
<212> DNA
<213> Artificial Sequence


<220> 
<223> T7AC tag

<400> 44
ctggaggatc cggaacgcaa caaagagcga aaggaagctg agttgcaagc tcaaaccgct     60

gagcaa                                                                66


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 45
Val Asp Val Ala Asp 
1               5   

<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 46
Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His 
1               5                   10                  15  

<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 47
Leu Leu Ser His Gly Val Glu Gly Ala Ala Ile Tyr Gly Val Asp Gly 
1               5                   10                  15      



<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 48
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 49
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 49
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 50
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 50
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 51
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 51
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 52
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 52
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Asp Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Gly Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Glu Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 53
<211> 882
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 53
atgcaccatc atcaccatca tggcaaaaat catgcaggta gtccgggttg tgaagaaagc      60

gcagcaggta aagaaaaact gccgaaaatg cgtctgccga cccgtagcga tatgatttgt     120

ggttatgcat gtctgaaagg caccgcagca atgcgtaata ccaaacgtgg tagctggtat     180

attgaagcac tggcacaggt ttttagcgaa cgtgcatgtg atatgcatgt tgcagatatg     240

ctggttgaag tgaacgccct gattaaagat cgtgaaggtt atgcaccggg tacagaattt     300

catcgttgta aagtaatgag cgagtattgt agcaccctgt gtcgacatct atacctgttt     360

ccgggtcatc ctccgaccgg atccggtccg gtttgtctgc aggttaaacc gtgtacaccg     420

gaattttatc agacccattt tcagctggca tatcgtctgc agagccgtcc gcgtggtctg     480

gcactggttc tgagcaatgt tcattttacc ggtgtaaaag aactggaatt tcgtagcggt     540

ggtgatgttg atcatagtac cctggttacc ctgtttaaac tgctgggtta tgacgttcat     600

gttctgtgtg atcagaccgc acaagaaatg caagagaaac tgcagaattt tgcacagctg     660

cctgcacatc gtgttaccga tagctgtatt gttgcactgc tgagccatgg tgttgaaggt     720

gcaatttatg gtgtggatgg caaactgctg caactgcaag aaatgtttca gctgtttgat     780

aatgcaaatt gtccgagcct gcagaataaa ccgaaaatgt tttttatcca ggcctgccgt     840

ggtgatgaaa cctatcgggg tgtggatcag caggattaat aa                        882


<210> 54
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 54
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Glu Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Val Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Met Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Tyr Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 55
<211> 558
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 55
atgagaggat ctcaccatca ccatcaccat ggcagcggcg tggatgtggc ggatgggatc      60

cgcatgcgag ctcggtaccc cagtgtgctg gacatggcgg ccagcaggag gctgatgaag     120

gagcttgaag aaatccgcaa atgtgggatg aaaaacttcc gtaacatcca ggttgatgaa     180

gctaatttat tgacttggca agggcttatt gttcctgaca accctcccta tgataaggga     240

gccttcagaa tcgaaatcaa ctttccagca gagtacccat tcaaaccacc gaagatcaca     300

tttaaaacaa agatctatca cccaaacatc gacgaaaagg ggcaggtctg tctgccagta     360

attagtgccg aaaactggaa gccagcaacc aaaaccgacc aagtaatcca gtccctcata     420

gcactggtga atgaccccca gcctgagcac ccgcttcggg ctgacctagc tgaagaatac     480

tctaaggacc gtaaaaaatt ctgtaagaat gctgaagagt ttacaaagaa atatggggaa     540

aagcgacctg tggactaa                                                   558


<210> 56
<211> 185
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<220> 
<221> SITE
<222> 19..19
<223> X can be any amino acid

<400> 56
Met Arg Gly Ser His His His His His His Gly Ser Gly Val Asp Val 
1               5                   10                  15      
Ala Asp Xaa Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met 
            20                  25                  30          
Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
        35                  40                  45              
Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
    50                  55                  60                  
Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
65                  70                  75                  80  
Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
                85                  90                  95      
Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
            100                 105                 110         
Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
        115                 120                 125             
Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
    130                 135                 140                 
Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
145                 150                 155                 160 
Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
                165                 170                 175     
Lys Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 185 

<210> 57
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 57
Met Arg Gly Ser His His His His His His Gly Ser Gly Asp Glu Val 
1               5                   10                  15      
Asp Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met Ala 
            20                  25                  30          
Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys Gly 
        35                  40                  45              
Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu Thr 
    50                  55                  60                  
Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly Ala 
65                  70                  75                  80  
Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro Pro 
                85                  90                  95      
Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu Lys 
            100                 105                 110         
Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro Ala 
        115                 120                 125             
Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn Asp 
    130                 135                 140                 
Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr Ser 
145                 150                 155                 160 
Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys Lys 
                165                 170                 175     
Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 

<210> 58
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 58
Met Arg Gly Ser His His His His His His Gly Ser Gly Glu Ile Ser 
1               5                   10                  15      
Asp Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met Ala 
            20                  25                  30          
Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys Gly 
        35                  40                  45              
Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu Thr 
    50                  55                  60                  
Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly Ala 
65                  70                  75                  80  
Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro Pro 
                85                  90                  95      
Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu Lys 
            100                 105                 110         
Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro Ala 
        115                 120                 125             
Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn Asp 
    130                 135                 140                 
Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr Ser 
145                 150                 155                 160 
Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys Lys 
                165                 170                 175     
Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 

<210> 59
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 59
Met Arg Gly Ser His His His His His His Gly Ser Gly Glu Phe Lys 
1               5                   10                  15      
Asp Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met Ala 
            20                  25                  30          
Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys Gly 
        35                  40                  45              
Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu Thr 
    50                  55                  60                  
Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly Ala 
65                  70                  75                  80  
Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro Pro 
                85                  90                  95      
Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu Lys 
            100                 105                 110         
Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro Ala 
        115                 120                 125             
Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn Asp 
    130                 135                 140                 
Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr Ser 
145                 150                 155                 160 
Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys Lys 
                165                 170                 175     
Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 

<210> 60
<211> 185
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 60
Met Arg Gly Ser His His His His His His Gly Ser Gly Val Asp Gln 
1               5                   10                  15      
Gln Glu Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met 
            20                  25                  30          
Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
        35                  40                  45              
Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
    50                  55                  60                  
Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
65                  70                  75                  80  
Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
                85                  90                  95      
Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
            100                 105                 110         
Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
        115                 120                 125             
Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
    130                 135                 140                 
Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
145                 150                 155                 160 
Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
                165                 170                 175     
Lys Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 185 

<210> 61
<211> 185
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 61
Met Arg Gly Ser His His His His His His Gly Ser Gly Val Asp Gln 
1               5                   10                  15      
Gln Ser Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met 
            20                  25                  30          
Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
        35                  40                  45              
Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
    50                  55                  60                  
Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
65                  70                  75                  80  
Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
                85                  90                  95      
Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
            100                 105                 110         
Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
        115                 120                 125             
Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
    130                 135                 140                 
Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
145                 150                 155                 160 
Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
                165                 170                 175     
Lys Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 185 

<210> 62
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 62
Met Arg Gly Ser His His His His His His Gly Ser Gly Asp Glu Thr 
1               5                   10                  15      
Glu Arg Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met Ala 
            20                  25                  30          
Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys Gly 
        35                  40                  45              
Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu Thr 
    50                  55                  60                  
Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly Ala 
65                  70                  75                  80  
Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro Pro 
                85                  90                  95      
Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu Lys 
            100                 105                 110         
Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro Ala 
        115                 120                 125             
Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn Asp 
    130                 135                 140                 
Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr Ser 
145                 150                 155                 160 
Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys Lys 
                165                 170                 175     
Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 

<210> 63
<211> 184
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 63
Met Arg Gly Ser His His His His His His Gly Ser Gly Asp Glu Thr 
1               5                   10                  15      
Asp Arg Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met Ala 
            20                  25                  30          
Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys Gly 
        35                  40                  45              
Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu Thr 
    50                  55                  60                  
Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly Ala 
65                  70                  75                  80  
Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro Pro 
                85                  90                  95      
Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu Lys 
            100                 105                 110         
Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro Ala 
        115                 120                 125             
Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn Asp 
    130                 135                 140                 
Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr Ser 
145                 150                 155                 160 
Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys Lys 
                165                 170                 175     
Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 

<210> 64
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 64
Met His His His His His His Gly Lys Glu His Met Ala Ser Pro Gly 
1               5                   10                  15      
Cys Glu Gln Ser Ala Ala Gly Lys Glu Lys Ile Leu Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Thr Gln Val Phe Ser Glu Arg Ala Arg Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Ser Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Pro Ser Leu Gln Val Lys Pro Cys Thr Ser Glu Phe Tyr Arg 
    130                 135                 140                 
Thr His His His Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Asn Gly Glu Lys Asp Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Ser Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Asp Tyr Asp Val His Val Leu Arg Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Tyr Glu Lys Leu Gln Arg Phe Ala Gln Leu Ser Thr His Gln 
    210                 215                 220                 
Asn Thr Asp Ser Cys Val Val Ala Leu Leu Ser His Gly Ile Glu Gly 
225                 230                 235                 240 
Gly Ile Tyr Gly Val Asp Gly Gln Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Leu Arg Asp 
    290         

<210> 65
<211> 885
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 65
atgatgcacc atcatcatca ccatggtaaa gaacacatgg caagtccggg ttgtgaacag      60

agcgcagcag gtaaagaaaa aattctgaaa atgcgtctgc cgacacgtag cgatatgatt     120

tgtggttatg catgtctgaa aggcaccgca gcaatgcgta ataccaaacg tggtagctgg     180

tatattgaag cactgaccca ggtttttagc gaacgtgccc gtgatatgca tgttgcagat     240

atgctggtta aagtgaacgc cctgattaaa gatcgtgaag gttatgcacc gggtacagaa     300

tttcatcgtt gtaaagaaat gagcgagtat agcagcaccc tgtgtcgtca tctgtacctg     360

tttccgggtc atcctccgac cggtagcggt ccgcctagcc tgcaggttaa accgtgtacc     420

agcgaatttt atcgtaccca tcaccatctg gcatatcgtc tgcagagccg tccgcgtggt     480

ctggcactgg ttctgagcaa tgttcatttt aatggcgaga aagatctgga atttcgtagc     540

ggtggtgatg ttgatcatag cagcctggtt accctgttta aactgctgga ttatgacgtt     600

catgttctgc gtgatcagac cgcacaagaa atgtatgaaa aactgcagcg ttttgcacag     660

ctgagcaccc atcagaatac cgatagctgt gttgttgccc tgctgagcca tggtattgaa     720

ggtggtattt atggtgttga tggtcagctg ctgcaactgc aagaagtttt tcagctgttt     780

gataatgcga attgtccgaa cctgcagaac aaaccgaaaa tgttttttat ccaggcatgc     840

cgtggtgatg aaaccgatcg tggtgtggat ctgcgcgatt aataa                     885


<210> 66
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 66
Met His His His His His His Gly Asn Asp Cys Ala Ser Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Thr Ala Ala Asn Lys Lys Glu Asn Pro Lys Leu Arg Leu 
            20                  25                  30          
Pro Thr Cys Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys His Gly Ser Trp Tyr Val Glu Ala Leu 
    50                  55                  60                  
Thr Ser Val Phe Ala Glu Asp Ser Gly His Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Arg Leu Ile Lys Leu Arg Glu Gly His Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Gln Asp Leu Tyr Leu Phe Pro Gly Tyr Phe Pro Gly Gly Ser 
        115                 120                 125             
Gly Pro His Tyr Pro Gln Val Met Pro Cys Thr Pro Glu Phe Tyr Arg 
    130                 135                 140                 
Thr His Glu Gln Leu Ala Tyr Lys Leu Lys Ser Gln Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Ile Leu Ser Asn Ile His Phe Asn Lys Glu Thr Asp Leu Asp 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp Asn Thr Ala Leu His Met Leu Phe 
            180                 185                 190         
Lys His Leu Gly Tyr Gln Val Val Val Arg Gln Asp Arg Thr Ala Gln 
        195                 200                 205             
Glu Met Lys Glu Glu Leu Glu Ile Phe Ser Lys His Pro Ala His Arg 
    210                 215                 220                 
Asn Val Asp Ser Cys Ile Val Ser Leu Leu Ser His Gly Ile Glu Gly 
225                 230                 235                 240 
Gly Ile Tyr Gly Ile Asp Gly Lys Leu Leu Gln Leu Gln Glu Ile Phe 
                245                 250                 255     
Arg Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Val Gln Ala Cys Arg Gly Asp Glu Thr Asp His Gly Val 
        275                 280                 285             
Asp Gln Ile Asp 
    290         

<210> 67
<211> 882
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 67
atgcatcatc accatcatca tggcaatgat tgtgcaagca gtccgggttg tgaagaaacc      60

gcagcaaaca aaaaagaaaa tccgaaactg cgtctgccga cctgtagcga tatgatttgt     120

ggttatgcat gtctgaaagg caccgcagcc atgcgtaata ccaaacatgg tagctggtat     180

gttgaagcac tgaccagcgt ttttgccgaa gatagcggtc acatgcacgt tgcagatatg     240

ctggttaaag ttaaccgtct gattaaactg cgtgaaggtc atgcaccggg tacagaattt     300

catcgttgta aagaaatgag cgagtattgt agcaccctgt gtcaggatct gtacctgttt     360

ccgggttatt ttcctggtgg tagcggtccg cattatccgc aggttatgcc gtgtacaccg     420

gaattttatc gtacccatga acagctggca tacaaactga aaagccagcc tcgtggtctg     480

gcactgattc tgagcaatat tcactttaac aaagaaaccg atctggattt tcgtagcggt     540

ggtgatgttg ataataccgc actgcacatg ctgttcaaac atctgggtta tcaggttgtt     600

gttcgtcagg atcgcaccgc acaagaaatg aaagaagaac tggaaatctt cagcaaacat     660

ccggcacatc gtaatgttga tagctgtatt gttagcctgc tgagccatgg tattgaaggt     720

ggtatttatg gcattgatgg taaactgctg caactgcaag aaatctttcg cctgtttgat     780

aatgccaatt gtccgaatct gcagaacaaa ccgaaaatgt tttttgttca ggcatgccgt     840

ggtgatgaaa cggatcatgg tgttgatcag atcgattgat aa                        882


<210> 68
<211> 295
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 68
Met His His His His His His Gly Ala Asp Ala Pro Gly Cys Glu Glu 
1               5                   10                  15      
Cys Ala Ala Gly Lys Glu Arg Glu Arg Thr Arg Arg Gly Lys Leu Pro 
            20                  25                  30          
Thr Gln Ser Asp Ile Ile Cys Gly Tyr Ala Cys Leu Arg Gly Thr Ala 
        35                  40                  45              
Ala Leu Arg Asn Thr Arg Gln Gly Ser Trp Tyr Ile Gln Ala Leu Val 
    50                  55                  60                  
Lys Val Phe Thr Glu Arg Ala His Asn Thr His Val Ala Asp Met Leu 
65                  70                  75                  80  
Val Gln Val Asn Ala Val Ile Arg Asp Arg Glu Gly Phe Ala Pro Gly 
                85                  90                  95      
Thr Asp Phe His Arg Cys Lys Glu Met Ala Glu Tyr Ser Ile Phe Glu 
            100                 105                 110         
Glu Met Glu Gly Glu Thr Gln Arg Lys Gln Arg Arg Arg Lys Thr Ala 
        115                 120                 125             
Ala Pro Gly Ser Gly Ser Gly Thr Phe Ser Val Arg Pro Thr Thr Ala 
    130                 135                 140                 
Gln Phe Tyr His Glu His His Lys Gln Ser Tyr Arg Met Ala Ser Arg 
145                 150                 155                 160 
Pro Arg Gly Ala Ala Leu Ile Val Ser Asn Glu Val Phe Val Gly Glu 
                165                 170                 175     
Gly Leu Gly His Arg Pro Gly Gly Ala Ala Asp Thr Gly Val Leu Arg 
            180                 185                 190         
Ala Leu Leu Ser Gln Leu Gly Tyr Arg Val Thr Ser Val Cys Asn Ser 
        195                 200                 205             
Pro Ala Gln Glu Leu Glu Thr Arg Leu Arg Asp Phe Ala Leu Ser Ala 
    210                 215                 220                 
Asp His Arg Arg Thr Asp Ser Cys Val Val Val Leu Leu Ser His Gly 
225                 230                 235                 240 
Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Val Gln Ile His 
                245                 250                 255     
Asp Ile Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn 
            260                 265                 270         
Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Arg Thr Asp 
        275                 280                 285             
Arg Gly Val Asp Arg Leu Asp 
    290                 295 

<210> 69
<211> 891
<212> DNA
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 69
atgcatcatc accatcatca tggtgcagat gcaccgggtt gtgaagaatg tgcagcaggt      60

aaagaacgtg aacgtacccg tcgtggtaaa ctgccgacac agagcgatat tatctgtggt     120

tatgcatgtc tgcgtggcac cgcagcactg cgtaataccc gtcaaggtag ctggtatatt     180

caggcactgg ttaaagtttt taccgaacgt gcacataata cccatgttgc agatatgctg     240

gttcaggtta atgcagttat tcgtgatcgt gaaggttttg ctccgggtac agattttcat     300

cgttgtaaag aaatggccga gtatagcatc tttgaagaaa tggaaggtga aacccagcgt     360

aaacagcgtc gtcgtaaaac cgcagcgcct ggtagcggta gcggcacctt tagcgttcgt     420

ccgaccaccg cacagtttta tcatgaacat cataaacaga gctatcgtat ggcaagccgt     480

ccgcgtggtg cagcactgat tgttagcaat gaagtttttg ttggtgaagg tctgggtcat     540

cgtcctggtg gtgccgcaga taccggtgtt ctgcgtgcac tgctgagcca gctgggttat     600

cgtgttacca gcgtttgtaa tagtccggca caagaactgg aaacccgtct gcgtgatttt     660

gcactgagcg cagatcatcg tcgtaccgat agctgtgttg ttgttctgct gagtcatggt     720

gttgaaggtg caatttatgg tgtggatggc aaactggttc agatccatga tatttttcag     780

ctgtttgata atgcgaattg cccgaatctg cagaacaaac cgaaaatgtt ttttatccag     840

gcatgtcgtg gtgatcgcac cgatcgtggt gttgatcgtc tggattaata a              891


<210> 70
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 70
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Asp Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Gly Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Glu Glu Thr Glu Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 71
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 71
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Lys Asn 
            20                  25                  30          
His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Val Met 
        115                 120                 125             
Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr 
            180                 185                 190         
Asp Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu 
    210                 215                 220                 
Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala 
225                 230                 235                 240 
Gln Leu Pro Ala His Arg Gly Thr Asp Ser Cys Ile Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Glu 
    290                 295                 300                 
Glu Thr Glu Arg Gly Val Asp Gln Gln Asp 
305                 310                 

<210> 72
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 72
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Lys Asn 
            20                  25                  30          
His Ala Gly Ser Pro Gly Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Val Met 
        115                 120                 125             
Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr 
            180                 185                 190         
Asp Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu 
    210                 215                 220                 
Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala 
225                 230                 235                 240 
Gln Leu Pro Ala His Arg Gly Thr Asp Ser Cys Ile Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Glu 
    290                 295                 300                 
Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
305                 310                 

<210> 73
<211> 290
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 73
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Pro 
        115                 120                 125             
Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His 
    130                 135                 140                 
Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu 
145                 150                 155                 160 
Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg 
                165                 170                 175     
Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu 
            180                 185                 190         
Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met 
        195                 200                 205             
Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr 
    210                 215                 220                 
Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile 
225                 230                 235                 240 
Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu 
                245                 250                 255     
Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe 
            260                 265                 270         
Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln 
        275                 280                 285             
Gln Asp 
    290 

<210> 74
<211> 295
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 74
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu 
    130                 135                 140                 
Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro 
145                 150                 155                 160 
Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys 
                165                 170                 175     
Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val 
            180                 185                 190         
Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln 
        195                 200                 205             
Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro 
    210                 215                 220                 
Ala His Arg Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly 
225                 230                 235                 240 
Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln 
                245                 250                 255     
Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn 
            260                 265                 270         
Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp 
        275                 280                 285             
Arg Gly Val Asp Gln Gln Asp 
    290                 295 

<210> 75
<211> 300
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 75
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Ala Gly Ser Ala Ala Gly Ser Gly Gly Pro Val Cys Leu Gln Val Lys 
    130                 135                 140                 
Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg 
145                 150                 155                 160 
Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His 
                165                 170                 175     
Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp 
            180                 185                 190         
His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His 
        195                 200                 205             
Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn 
    210                 215                 220                 
Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala 
225                 230                 235                 240 
Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys 
                245                 250                 255     
Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys 
            260                 265                 270         
Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg 
        275                 280                 285             
Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
    290                 295                 300 

<210> 76
<211> 277
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 76
Met His His His His His His Gly Lys Glu Lys Leu Pro Lys Met Arg 
1               5                   10                  15      
Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly 
            20                  25                  30          
Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala 
        35                  40                  45              
Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp 
    50                  55                  60                  
Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala 
65                  70                  75                  80  
Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser 
                85                  90                  95      
Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly 
            100                 105                 110         
Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr 
        115                 120                 125             
Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly 
    130                 135                 140                 
Leu Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu 
145                 150                 155                 160 
Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu 
                165                 170                 175     
Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala 
            180                 185                 190         
Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His 
        195                 200                 205             
Arg Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu 
    210                 215                 220                 
Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val 
225                 230                 235                 240 
Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro 
                245                 250                 255     
Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly 
            260                 265                 270         
Val Asp Gln Gln Asp 
        275         

<210> 77
<211> 284
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 77
Met His His His His His His Gly Cys Glu Glu Ser Ala Ala Gly Lys 
1               5                   10                  15      
Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys 
            20                  25                  30          
Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg 
        35                  40                  45              
Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala 
    50                  55                  60                  
Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile 
65                  70                  75                  80  
Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
                85                  90                  95      
Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe 
            100                 105                 110         
Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys 
        115                 120                 125             
Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg 
    130                 135                 140                 
Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His 
145                 150                 155                 160 
Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp 
                165                 170                 175     
His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His 
            180                 185                 190         
Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn 
        195                 200                 205             
Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala 
    210                 215                 220                 
Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys 
225                 230                 235                 240 
Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys 
                245                 250                 255     
Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg 
            260                 265                 270         
Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
        275                 280                 

<210> 78
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 78
Met His His His His His His Gly Lys Glu His Met Ala Ser Pro Gly 
1               5                   10                  15      
Cys Glu Gln Ser Ala Ala Gly Lys Glu Lys Ile Leu Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Thr Gln Val Phe Ser Glu Arg Ala Arg Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Ser Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Pro Ser Leu Gln Val Lys Pro Cys Thr Ser Glu Phe Tyr Arg 
    130                 135                 140                 
Thr His His His Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Asn Gly Val Lys Asp Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Ser Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Asp Tyr Asp Val His Val Leu Arg Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Tyr Glu Lys Leu Gln Arg Phe Ala Gln Leu Ser Thr His Gln 
    210                 215                 220                 
Asn Thr Asp Ser Cys Val Val Ala Leu Leu Ser His Gly Ile Glu Gly 
225                 230                 235                 240 
Gly Ile Tyr Gly Val Asp Gly Gln Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Leu Arg Asp 
    290         

<210> 79
<211> 295
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 79
Met His His His His His His Gly Ala Asp Ala Pro Gly Cys Glu Glu 
1               5                   10                  15      
Cys Ala Ala Gly Lys Glu Arg Glu Arg Thr Arg Arg Gly Lys Leu Pro 
            20                  25                  30          
Thr Gln Ser Asp Ile Ile Cys Gly Tyr Ala Cys Leu Arg Gly Thr Ala 
        35                  40                  45              
Ala Leu Arg Asn Thr Arg Gln Gly Ser Trp Tyr Ile Gln Ala Leu Val 
    50                  55                  60                  
Lys Val Phe Thr Glu Arg Ala His Asn Thr His Val Ala Asp Met Leu 
65                  70                  75                  80  
Val Gln Val Asn Ala Val Ile Arg Asp Arg Glu Gly Phe Ala Pro Gly 
                85                  90                  95      
Thr Asp Phe His Arg Cys Lys Val Met Ala Glu Tyr Ser Ile Phe Glu 
            100                 105                 110         
Glu Met Glu Gly Glu Thr Gln Arg Lys Gln Arg Arg Arg Lys Thr Ala 
        115                 120                 125             
Ala Pro Gly Ser Gly Ser Gly Thr Phe Ser Val Arg Pro Thr Thr Ala 
    130                 135                 140                 
Gln Phe Tyr His Glu His His Lys Gln Ser Tyr Arg Met Ala Ser Arg 
145                 150                 155                 160 
Pro Arg Gly Ala Ala Leu Ile Val Ser Asn Glu Val Phe Val Asp Glu 
                165                 170                 175     
Gly Leu Gly His Arg Pro Gly Gly Ala Ala Asp Thr Gly Val Leu Arg 
            180                 185                 190         
Ala Leu Leu Ser Gln Leu Gly Tyr Arg Val Thr Ser Val Cys Asn Ser 
        195                 200                 205             
Pro Ala Gln Glu Leu Glu Thr Arg Leu Arg Asp Phe Ala Leu Ser Ala 
    210                 215                 220                 
Asp His Arg Arg Thr Asp Ser Cys Val Val Val Leu Leu Ser His Gly 
225                 230                 235                 240 
Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Val Gln Ile His 
                245                 250                 255     
Asp Ile Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn 
            260                 265                 270         
Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Arg Thr Asp 
        275                 280                 285             
Arg Gly Val Asp Arg Leu Asp 
    290                 295 

<210> 80
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 80
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Cys Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 81
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 81
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp His Gly Ala 
        275                 280                 285             
Val Leu Arg Gly 
    290         

<210> 82
<211> 277
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 82
Met His His His His His His Lys Leu Pro Lys Met Arg Leu Pro Thr 
1               5                   10                  15      
Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala 
            20                  25                  30          
Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln 
        35                  40                  45              
Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val 
    50                  55                  60                  
Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr 
65                  70                  75                  80  
Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys 
                85                  90                  95      
Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro 
            100                 105                 110         
Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His 
        115                 120                 125             
Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu 
    130                 135                 140                 
Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg 
145                 150                 155                 160 
Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu 
                165                 170                 175     
Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met 
            180                 185                 190         
Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr 
        195                 200                 205             
Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile 
    210                 215                 220                 
Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu 
225                 230                 235                 240 
Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe 
                245                 250                 255     
Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val Asp Gln 
            260                 265                 270         
Gln Ser Gly Lys Glu 
        275         

<210> 83
<211> 277
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 83
Met His His His His His His Gln Gln Asp Gly Lys Glu Lys Leu Pro 
1               5                   10                  15      
Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys 
            20                  25                  30          
Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr 
        35                  40                  45              
Ile Glu Ala Leu Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His 
    50                  55                  60                  
Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu 
65                  70                  75                  80  
Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu 
                85                  90                  95      
Tyr Cys Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro 
            100                 105                 110         
Pro Thr Gly Ser Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro 
        115                 120                 125             
Glu Phe Tyr Gln Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg 
    130                 135                 140                 
Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu 
145                 150                 155                 160 
Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu 
                165                 170                 175     
Val Thr Leu Phe Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp 
            180                 185                 190         
Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu 
        195                 200                 205             
Pro Ala His Arg Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His 
    210                 215                 220                 
Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu 
225                 230                 235                 240 
Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln 
                245                 250                 255     
Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr 
            260                 265                 270         
Asp Arg Gly Val Asp 
        275         

<210> 84
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 84
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Lys Glu 
            20                  25                  30          
His Met Ala Ser Pro Gly Cys Glu Gln Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Ile Leu Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Thr Gln Val Phe Ser Glu Arg Ala Arg Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
        115                 120                 125             
Ser Glu Tyr Ser Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Pro Ser Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Ser Glu Phe Tyr Arg Thr His His His Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Asn 
            180                 185                 190         
Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Ser Leu Val Thr Leu Phe Lys Leu Leu Asp Tyr Asp Val His Val Leu 
    210                 215                 220                 
Arg Asp Gln Thr Ala Gln Glu Met Tyr Glu Lys Leu Gln Arg Phe Ala 
225                 230                 235                 240 
Gln Leu Ser Thr His Gln Asn Thr Asp Ser Cys Val Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Ile Glu Gly Gly Ile Tyr Gly Val Asp Gly Gln Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp 
    290                 295                 300                 
Glu Thr Asp Arg Gly Val Asp Leu Arg Asp 
305                 310                 

<210> 85
<211> 317
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 85
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ala Asp 
            20                  25                  30          
Ala Pro Gly Cys Glu Glu Cys Ala Ala Gly Lys Glu Arg Glu Arg Thr 
        35                  40                  45              
Arg Arg Gly Lys Leu Pro Thr Gln Ser Asp Ile Ile Cys Gly Tyr Ala 
    50                  55                  60                  
Cys Leu Arg Gly Thr Ala Ala Leu Arg Asn Thr Arg Gln Gly Ser Trp 
65                  70                  75                  80  
Tyr Ile Gln Ala Leu Val Lys Val Phe Thr Glu Arg Ala His Asn Thr 
                85                  90                  95      
His Val Ala Asp Met Leu Val Gln Val Asn Ala Val Ile Arg Asp Arg 
            100                 105                 110         
Glu Gly Phe Ala Pro Gly Thr Asp Phe His Arg Cys Lys Glu Met Ala 
        115                 120                 125             
Glu Tyr Ser Ile Phe Glu Glu Met Glu Gly Glu Thr Gln Arg Lys Gln 
    130                 135                 140                 
Arg Arg Arg Lys Thr Ala Ala Pro Gly Ser Gly Ser Gly Thr Phe Ser 
145                 150                 155                 160 
Val Arg Pro Thr Thr Ala Gln Phe Tyr His Glu His His Lys Gln Ser 
                165                 170                 175     
Tyr Arg Met Ala Ser Arg Pro Arg Gly Ala Ala Leu Ile Val Ser Asn 
            180                 185                 190         
Glu Val Phe Val Gly Glu Gly Leu Gly His Arg Pro Gly Gly Ala Ala 
        195                 200                 205             
Asp Thr Gly Val Leu Arg Ala Leu Leu Ser Gln Leu Gly Tyr Arg Val 
    210                 215                 220                 
Thr Ser Val Cys Asn Ser Pro Ala Gln Glu Leu Glu Thr Arg Leu Arg 
225                 230                 235                 240 
Asp Phe Ala Leu Ser Ala Asp His Arg Arg Thr Asp Ser Cys Val Val 
                245                 250                 255     
Val Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
            260                 265                 270         
Lys Leu Val Gln Ile His Asp Ile Phe Gln Leu Phe Asp Asn Ala Asn 
        275                 280                 285             
Cys Pro Asn Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
    290                 295                 300                 
Arg Gly Asp Arg Thr Asp Arg Gly Val Asp Arg Leu Asp 
305                 310                 315         

<210> 86
<211> 314
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 86
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Lys Glu 
            20                  25                  30          
His Met Ala Ser Pro Gly Cys Glu Gln Ser Ala Ala Gly Lys Glu Lys 
        35                  40                  45              
Ile Leu Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
    50                  55                  60                  
Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
65                  70                  75                  80  
Trp Tyr Ile Glu Ala Leu Thr Gln Val Phe Ser Glu Arg Ala Arg Asp 
                85                  90                  95      
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Asp 
            100                 105                 110         
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Val Met 
        115                 120                 125             
Ser Glu Tyr Ser Ser Thr Leu Cys Arg His Leu Tyr Leu Phe Pro Gly 
    130                 135                 140                 
His Pro Pro Thr Gly Ser Gly Pro Pro Ser Leu Gln Val Lys Pro Cys 
145                 150                 155                 160 
Thr Ser Glu Phe Tyr Arg Thr His His His Leu Ala Tyr Arg Leu Gln 
                165                 170                 175     
Ser Arg Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Asn 
            180                 185                 190         
Gly Val Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser 
        195                 200                 205             
Ser Leu Val Thr Leu Phe Lys Leu Leu Asp Tyr Asp Val His Val Leu 
    210                 215                 220                 
Arg Asp Gln Thr Ala Gln Glu Met Tyr Glu Lys Leu Gln Arg Phe Ala 
225                 230                 235                 240 
Gln Leu Ser Thr His Gln Asn Thr Asp Ser Cys Val Val Ala Leu Leu 
                245                 250                 255     
Ser His Gly Ile Glu Gly Gly Ile Tyr Gly Val Asp Gly Gln Leu Leu 
            260                 265                 270         
Gln Leu Gln Glu Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn 
        275                 280                 285             
Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp 
    290                 295                 300                 
Glu Thr Asp Arg Gly Val Asp Leu Arg Asp 
305                 310                 

<210> 87
<211> 317
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 87
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ala Asp 
            20                  25                  30          
Ala Pro Gly Cys Glu Glu Cys Ala Ala Gly Lys Glu Arg Glu Arg Thr 
        35                  40                  45              
Arg Arg Gly Lys Leu Pro Thr Gln Ser Asp Ile Ile Cys Gly Tyr Ala 
    50                  55                  60                  
Cys Leu Arg Gly Thr Ala Ala Leu Arg Asn Thr Arg Gln Gly Ser Trp 
65                  70                  75                  80  
Tyr Ile Gln Ala Leu Val Lys Val Phe Thr Glu Arg Ala His Asn Thr 
                85                  90                  95      
His Val Ala Asp Met Leu Val Gln Val Asn Ala Val Ile Arg Asp Arg 
            100                 105                 110         
Glu Gly Phe Ala Pro Gly Thr Asp Phe His Arg Cys Lys Val Met Ala 
        115                 120                 125             
Glu Tyr Ser Ile Phe Glu Glu Met Glu Gly Glu Thr Gln Arg Lys Gln 
    130                 135                 140                 
Arg Arg Arg Lys Thr Ala Ala Pro Gly Ser Gly Ser Gly Thr Phe Ser 
145                 150                 155                 160 
Val Arg Pro Thr Thr Ala Gln Phe Tyr His Glu His His Lys Gln Ser 
                165                 170                 175     
Tyr Arg Met Ala Ser Arg Pro Arg Gly Ala Ala Leu Ile Val Ser Asn 
            180                 185                 190         
Glu Val Phe Val Asp Glu Gly Leu Gly His Arg Pro Gly Gly Ala Ala 
        195                 200                 205             
Asp Thr Gly Val Leu Arg Ala Leu Leu Ser Gln Leu Gly Tyr Arg Val 
    210                 215                 220                 
Thr Ser Val Cys Asn Ser Pro Ala Gln Glu Leu Glu Thr Arg Leu Arg 
225                 230                 235                 240 
Asp Phe Ala Leu Ser Ala Asp His Arg Arg Thr Asp Ser Cys Val Val 
                245                 250                 255     
Val Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
            260                 265                 270         
Lys Leu Val Gln Ile His Asp Ile Phe Gln Leu Phe Asp Asn Ala Asn 
        275                 280                 285             
Cys Pro Asn Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
    290                 295                 300                 
Arg Gly Asp Arg Thr Asp Arg Gly Val Asp Arg Leu Asp 
305                 310                 315         

<210> 88
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 88
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Cys Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 89
<211> 452
<212> PRT
<213> Mus <mouse, genus>


<400> 89
Met Ala Ala Pro Ser Gly Arg Ser Gln Ser Ser Leu His Arg Lys Gly 
1               5                   10                  15      
Leu Met Ala Ala Asp Arg Arg Ser Arg Ile Leu Ala Val Cys Gly Met 
            20                  25                  30          
His Pro Asp His Gln Glu Thr Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              
Lys Gln Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Lys Asp 
    50                  55                  60                  
Ile Ile Thr Leu Glu Met Arg Glu Leu Ile Gln Ala Lys Gly Gly Ser 
65                  70                  75                  80  
Phe Ser Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      
Gln Ala Phe Asp Ala Phe Cys Glu Ala Leu Arg Glu Thr Arg Gln Gly 
            100                 105                 110         
His Leu Glu Asp Leu Leu Leu Thr Thr Leu Ser Asp Ile Gln His Val 
        115                 120                 125             
Leu Pro Pro Leu Ser Cys Asp Tyr Asp Thr Ser Leu Pro Phe Ser Val 
    130                 135                 140                 
Cys Glu Ser Cys Pro Pro His Lys Gln Leu Arg Leu Ser Thr Asp Ala 
145                 150                 155                 160 
Thr Glu His Ser Leu Asp Asn Gly Asp Gly Pro Pro Cys Leu Leu Val 
                165                 170                 175     
Lys Pro Cys Thr Pro Glu Phe Tyr Gln Ala His Tyr Gln Leu Ala Tyr 
            180                 185                 190         
Arg Leu Gln Ser Gln Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val 
        195                 200                 205             
His Phe Thr Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val 
    210                 215                 220                 
Asp His Thr Thr Leu Val Thr Leu Phe Lys Leu Leu Gly Tyr Asn Val 
225                 230                 235                 240 
His Val Leu His Asp Gln Thr Ala Gln Glu Met Gln Glu Lys Leu Gln 
                245                 250                 255     
Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser Cys Val Val 
            260                 265                 270         
Ala Leu Leu Ser His Gly Val Glu Gly Gly Ile Tyr Gly Val Asp Gly 
        275                 280                 285             
Lys Leu Leu Gln Leu Gln Glu Val Phe Arg Leu Phe Asp Asn Ala Asn 
    290                 295                 300                 
Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
305                 310                 315                 320 
Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp Gly Lys Asn 
                325                 330                 335     
His Thr Gln Ser Pro Gly Cys Glu Glu Ser Asp Ala Gly Lys Glu Glu 
            340                 345                 350         
Leu Met Lys Met Arg Leu Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr 
        355                 360                 365             
Ala Cys Leu Lys Gly Asn Ala Ala Met Arg Asn Thr Lys Arg Gly Ser 
    370                 375                 380                 
Trp Tyr Ile Glu Ala Leu Thr Gln Val Phe Ser Glu Arg Ala Cys Asp 
385                 390                 395                 400 
Met His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Glu 
                405                 410                 415     
Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
            420                 425                 430         
Ser Glu Tyr Cys Ser Thr Leu Cys Gln Gln Leu Tyr Leu Phe Pro Gly 
        435                 440                 445             
Tyr Pro Pro Thr 
    450         

<210> 90
<211> 164
<212> PRT
<213> Mus <mouse, genus>


<400> 90
Gly Pro Pro Cys Leu Leu Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
1               5                   10                  15      
Ala His Tyr Gln Leu Ala Tyr Arg Leu Gln Ser Gln Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Asp Leu Glu 
        35                  40                  45              
Phe Arg Ser Gly Gly Asp Val Asp His Thr Thr Leu Val Thr Leu Phe 
    50                  55                  60                  
Lys Leu Leu Gly Tyr Asn Val His Val Leu His Asp Gln Thr Ala Gln 
65                  70                  75                  80  
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
                85                  90                  95      
Val Thr Asp Ser Cys Val Val Ala Leu Leu Ser His Gly Val Glu Gly 
            100                 105                 110         
Gly Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
        115                 120                 125             
Arg Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
    130                 135                 140                 
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
145                 150                 155                 160 
Asp Gln Gln Asp 
                

<210> 91
<211> 105
<212> PRT
<213> Mus <mouse, genus>


<400> 91
Ala Gly Lys Glu Glu Leu Met Lys Met Arg Leu Pro Thr Arg Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Asn Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr Gln Val Phe Ser 
        35                  40                  45              
Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Ala Leu Ile Lys Glu Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Gln Gln Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly Tyr Pro Pro Thr 
            100                 105 

<210> 92
<211> 461
<212> PRT
<213> Ovis


<400> 92
Met Ala Ala Pro Ser Ala Gly Ser Gln Ser Ala Leu Gln Pro Lys Glu 
1               5                   10                  15      
Gln Met Ala Ala Asp Arg Gly Arg Arg Met Leu Arg Gly Cys Gly Met 
            20                  25                  30          
His Pro Asp His Gln Glu Ala Leu Lys Lys Asn Arg Val Val Leu Ala 
        35                  40                  45              
Lys Glu Leu Leu Leu Ser Glu Leu Leu Glu His Leu Leu Glu Arg Asp 
    50                  55                  60                  
Ile Ile Thr Leu Glu Met Arg Glu His Ile Gln Ala Lys Thr Gly Ser 
65                  70                  75                  80  
Phe Gly Gln Asn Val Glu Leu Leu Asn Leu Leu Pro Lys Arg Gly Pro 
                85                  90                  95      
Gln Ala Phe Asp Ala Phe Cys Val Ala Leu Arg Glu Thr Lys Gln Ser 
            100                 105                 110         
His Leu Glu Glu Leu Leu Leu Arg Thr Leu Ser Gly Leu Gln Pro Val 
        115                 120                 125             
Val Pro Pro Leu Ser Cys Asp Tyr Asp Leu Ser Leu Pro Phe Pro Val 
    130                 135                 140                 
Cys Glu Ser Cys Ala Pro His Lys Arg Leu Arg Leu Ser Pro Gly Leu 
145                 150                 155                 160 
Cys Ala Ala Asp Ala Val Glu His Ser Leu Asp His Gly Asp Gly Pro 
                165                 170                 175     
Pro Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His 
            180                 185                 190         
His Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu 
        195                 200                 205             
Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Asp Leu Glu Phe Arg 
    210                 215                 220                 
Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu 
225                 230                 235                 240 
Leu Gly Tyr Lys Val His Val Leu Leu Asp Gln Thr Ala Gln Glu Met 
                245                 250                 255     
Gln Glu Lys Leu Gln Ser Phe Ala Gln Leu Pro Ala Pro Arg Leu Thr 
            260                 265                 270         
Asp Ser Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu 
        275                 280                 285             
Gly Ser Val Tyr Gly Val Asp Gly Lys Leu Leu Gln Gln Leu Gln Glu 
    290                 295                 300                 
Val Phe Arg Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys 
305                 310                 315                 320 
Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg 
                325                 330                 335     
Gly Val Asp Gln Gln Asp Gly Lys Asn His Asp Arg Ser Pro Glu Cys 
            340                 345                 350         
Glu Glu Ser Asp Ala Ser Gly Glu Glu Leu Leu Lys Thr Arg Leu Pro 
        355                 360                 365             
Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Arg Gly Thr Ala 
    370                 375                 380                 
Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Val Glu Ala Leu Thr 
385                 390                 395                 400 
Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu 
                405                 410                 415     
Val Lys Val Asn Ala Leu Ile Lys Glu Arg Glu Gly Tyr Ala Pro Gly 
            420                 425                 430         
Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu 
        435                 440                 445             
Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr 
    450                 455                 460     

<210> 93
<211> 168
<212> PRT
<213> Ovis


<400> 93
Gly Pro Pro Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
1               5                   10                  15      
Thr His His Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Asp Leu Glu 
        35                  40                  45              
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
    50                  55                  60                  
Lys Leu Leu Gly Tyr Lys Val His Val Leu Leu Asp Gln Thr Ala Gln 
65                  70                  75                  80  
Glu Met Gln Glu Lys Leu Gln Ser Phe Ala Gln Leu Pro Ala Pro Arg 
                85                  90                  95      
Leu Thr Asp Ser Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly 
            100                 105                 110         
Val Glu Gly Ser Val Tyr Gly Val Asp Gly Lys Leu Leu Gln Gln Leu 
        115                 120                 125             
Gln Glu Val Phe Arg Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln 
    130                 135                 140                 
Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr 
145                 150                 155                 160 
Asp Arg Gly Val Asp Gln Gln Asp 
                165             

<210> 94
<211> 105
<212> PRT
<213> Ovis


<400> 94
Ala Ser Gly Glu Glu Leu Leu Lys Thr Arg Leu Pro Thr Arg Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Arg Gly Thr Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys Arg Gly Ser Trp Tyr Val Glu Ala Leu Thr Gln Val Phe Ser 
        35                  40                  45              
Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Ala Leu Ile Lys Glu Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly His Pro Pro Thr 
            100                 105 

<210> 95
<211> 429
<212> PRT
<213> Sarcophilus harrisii


<400> 95
Ser Arg Met Leu Gly Val Trp Gly Met Glu Arg Glu His Gln Glu Ala 
1               5                   10                  15      
Leu Lys Lys Asn Arg Val Val Leu Ala Lys Gln Leu Leu Leu Ser Glu 
            20                  25                  30          
Leu Leu Glu His Leu Leu Glu Lys Asp Ile Ile Thr Leu Glu Met Arg 
        35                  40                  45              
Glu Leu Ile Gln Ala Lys Val Gly Ser Phe Ser Gln Asn Val Glu Phe 
    50                  55                  60                  
Leu Asn Leu Leu Pro Lys Arg Gly Pro His Ala Phe Gly Ala Phe Cys 
65                  70                  75                  80  
Asp Ala Leu Arg Glu Thr Lys Gln Gly His Leu Glu Asp Leu Leu His 
                85                  90                  95      
Lys Thr Leu Tyr Ser Phe Gln Gln Leu Leu Pro Ser Leu Asn Cys Asp 
            100                 105                 110         
Asp Asp Ser Asn Leu Pro Leu Pro Val Cys Glu Ser Cys Ser Pro His 
        115                 120                 125             
Lys Gln Leu Arg Leu Ser Val Glu Thr Met Glu His Ser Leu Asp Asn 
    130                 135                 140                 
Gly Asp Gly Pro Pro Ser Leu Gln Val Lys Pro Cys Thr Ser Glu Phe 
145                 150                 155                 160 
Tyr Arg Thr His His His Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg 
                165                 170                 175     
Gly Leu Ala Leu Val Leu Ser Asn Val His Phe Asn Gly Glu Lys Asp 
            180                 185                 190         
Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His Ser Ser Leu Val Thr 
        195                 200                 205             
Leu Phe Lys Leu Leu Asp Tyr Asp Val His Val Leu Arg Asp Gln Thr 
    210                 215                 220                 
Ala Gln Glu Met Tyr Glu Lys Leu Gln Arg Phe Ala Gln Leu Ser Thr 
225                 230                 235                 240 
His Gln Asn Thr Asp Ser Cys Val Val Ala Leu Leu Ser His Gly Ile 
                245                 250                 255     
Glu Gly Gly Ile Tyr Gly Val Asp Gly Gln Leu Leu Gln Leu Gln Glu 
            260                 265                 270         
Val Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys 
        275                 280                 285             
Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg 
    290                 295                 300                 
Gly Val Asp Leu Arg Asp Gly Lys Glu His Met Ala Ser Pro Gly Cys 
305                 310                 315                 320 
Glu Gln Ser Asp Ala Gly Lys Glu Lys Ile Leu Lys Met Arg Leu Pro 
                325                 330                 335     
Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala 
            340                 345                 350         
Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr 
        355                 360                 365             
Gln Val Phe Ser Glu Arg Ala Arg Asp Met His Val Ala Asp Met Leu 
    370                 375                 380                 
Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly 
385                 390                 395                 400 
Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Ser Ser Thr Leu 
                405                 410                 415     
Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr 
            420                 425                 

<210> 96
<211> 164
<212> PRT
<213> Sarcophilus harrisii


<400> 96
Gly Pro Pro Ser Leu Gln Val Lys Pro Cys Thr Ser Glu Phe Tyr Arg 
1               5                   10                  15      
Thr His His His Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Val Leu Ser Asn Val His Phe Asn Gly Glu Lys Asp Leu Glu 
        35                  40                  45              
Phe Arg Ser Gly Gly Asp Val Asp His Ser Ser Leu Val Thr Leu Phe 
    50                  55                  60                  
Lys Leu Leu Asp Tyr Asp Val His Val Leu Arg Asp Gln Thr Ala Gln 
65                  70                  75                  80  
Glu Met Tyr Glu Lys Leu Gln Arg Phe Ala Gln Leu Ser Thr His Gln 
                85                  90                  95      
Asn Thr Asp Ser Cys Val Val Ala Leu Leu Ser His Gly Ile Glu Gly 
            100                 105                 110         
Gly Ile Tyr Gly Val Asp Gly Gln Leu Leu Gln Leu Gln Glu Val Phe 
        115                 120                 125             
Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys 
    130                 135                 140                 
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
145                 150                 155                 160 
Asp Leu Arg Asp 
                

<210> 97
<211> 105
<212> PRT
<213> Sarcophilus harrisii


<400> 97
Ala Gly Lys Glu Lys Ile Leu Lys Met Arg Leu Pro Thr Arg Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr Gln Val Phe Ser 
        35                  40                  45              
Glu Arg Ala Arg Asp Met His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Ser Ser Thr Leu Cys Arg His Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly His Pro Pro Thr 
            100                 105 

<210> 98
<211> 424
<212> PRT
<213> Gallus


<400> 98
Met Leu Gly Ala Cys Gly Met Gln Arg Tyr His Gln Glu Ala Leu Lys 
1               5                   10                  15      
Lys Asn Arg Val Met Leu Ala Arg Glu Leu Val Leu Lys Glu Leu Met 
            20                  25                  30          
Glu His Met Ile Glu Lys Asp Ile Ile Thr Ile Glu Met Val Glu Met 
        35                  40                  45              
Ile Gln Ala Lys Ser Gly Ser Phe Ser Gln Asn Val Glu Phe Leu Asn 
    50                  55                  60                  
Leu Leu Pro Lys Arg Gly Pro Asn Ala Phe Ser Ala Phe Cys Glu Ala 
65                  70                  75                  80  
Leu Gln Glu Thr Lys Gln Gln His Leu Ala Glu Met Ile Leu Lys Thr 
                85                  90                  95      
Glu Ser Ser Leu Arg His Gly Ile Ala Thr Leu Glu Gln Arg Tyr Gly 
            100                 105                 110         
Ser Asn Leu Pro Leu Pro Leu Ser Glu Ser Cys Asn Ser Lys Arg Pro 
        115                 120                 125             
Arg Leu Ile Val Glu His Ser Leu Asp Ser Gly Asp Gly Pro Pro Ile 
    130                 135                 140                 
Pro Pro Val Lys His Cys Thr Pro Glu Phe Tyr Arg Asp His Gln His 
145                 150                 155                 160 
Leu Ala Tyr Lys Leu Ile Ser Glu Pro Arg Gly Leu Ala Leu Ile Leu 
                165                 170                 175     
Ser Asn Ile His Phe Ser Ser Glu Lys Asp Leu Glu Tyr Arg Ser Gly 
            180                 185                 190         
Gly Asp Val Asp Cys Ala Ser Leu Glu Leu Leu Phe Lys His Leu Gly 
        195                 200                 205             
Tyr Gln Val Thr Val Phe His Asp Gln Ser Ala Glu Glu Met Glu Ser 
    210                 215                 220                 
Ala Leu Glu Arg Phe Ser Lys Leu Pro Asp His Gln Asp Val Asp Ser 
225                 230                 235                 240 
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Gly Val Tyr Gly 
                245                 250                 255     
Thr Asp Gly Lys Leu Leu Gln Leu Gln Glu Ala Phe Arg Leu Phe Asp 
            260                 265                 270         
Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
        275                 280                 285             
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Arg Asp 
    290                 295                 300                 
Gly Lys Glu Arg Ser Asp Ser Pro Gly Cys Glu Glu Ser Asp Ala Asn 
305                 310                 315                 320 
Lys Glu Glu Asn Leu Lys Leu Arg Leu Pro Thr Arg Ser Asp Met Ile 
                325                 330                 335     
Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys 
            340                 345                 350         
Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr Thr Val Phe Ala Glu Asp 
        355                 360                 365             
Ser Arg Asp Thr His Val Ala Asp Met Leu Val Lys Val Asn Arg Gln 
    370                 375                 380                 
Ile Lys Gln Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys 
385                 390                 395                 400 
Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg Asp Leu Tyr Leu 
                405                 410                 415     
Phe Pro Gly Tyr Val Pro Gly Lys 
            420                 

<210> 99
<211> 164
<212> PRT
<213> Gallus


<400> 99
Gly Pro Pro Ile Pro Pro Val Lys His Cys Thr Pro Glu Phe Tyr Arg 
1               5                   10                  15      
Asp His Gln His Leu Ala Tyr Lys Leu Ile Ser Glu Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Ile Leu Ser Asn Ile His Phe Ser Ser Glu Lys Asp Leu Glu 
        35                  40                  45              
Tyr Arg Ser Gly Gly Asp Val Asp Cys Ala Ser Leu Glu Leu Leu Phe 
    50                  55                  60                  
Lys His Leu Gly Tyr Gln Val Thr Val Phe His Asp Gln Ser Ala Glu 
65                  70                  75                  80  
Glu Met Glu Ser Ala Leu Glu Arg Phe Ser Lys Leu Pro Asp His Gln 
                85                  90                  95      
Asp Val Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
            100                 105                 110         
Gly Val Tyr Gly Thr Asp Gly Lys Leu Leu Gln Leu Gln Glu Ala Phe 
        115                 120                 125             
Arg Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys 
    130                 135                 140                 
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
145                 150                 155                 160 
Asp Gln Arg Asp 
                

<210> 100
<211> 106
<212> PRT
<213> Gallus


<400> 100
Ala Asn Lys Glu Glu Asn Leu Lys Leu Arg Leu Pro Thr Arg Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr Thr Val Phe Ala 
        35                  40                  45              
Glu Asp Ser Arg Asp Thr His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Arg Gln Ile Lys Gln Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg Asp Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly Tyr Val Pro Gly Lys 
            100                 105     

<210> 101
<211> 446
<212> PRT
<213> Anolis carolinensis


<400> 101
Met Glu His Val Glu Ser Lys Phe His Leu Cys Ile Val Ile Cys Phe 
1               5                   10                  15      
Ile Ser Arg Met Leu Gly Val Cys Gly Met Gln Lys Cys His Gln Glu 
            20                  25                  30          
Ala Leu Lys Lys Asn Arg Val Ser Leu Ala Lys Gln Leu Val Leu Lys 
        35                  40                  45              
Glu Leu Met Glu His Leu Ile Glu Lys Asp Val Ile Thr Glu Glu Met 
    50                  55                  60                  
Met Glu Met Ile Gln Ala Lys Ala Gly Asn Phe Ser Gln Asn Ile Glu 
65                  70                  75                  80  
Phe Leu Asn Leu Leu Pro Lys Arg Gly Pro Lys Ala Phe Ser Ala Phe 
                85                  90                  95      
Cys Glu Ala Leu Arg Glu Thr Lys Gln Pro His Leu Glu Glu Met Leu 
            100                 105                 110         
Leu Arg Ser Val Ser Arg His Cys Asn Gly Ile Ala Lys Leu Ser His 
        115                 120                 125             
Ser Cys Glu Glu His Leu Ser Phe Pro Val Ser Glu Ser Gly Ile Leu 
    130                 135                 140                 
Gln Lys Trp Pro Arg Arg Asn Pro Glu Pro Met Glu His Ser Leu Asp 
145                 150                 155                 160 
Asp Gly Asp Gly Pro His Tyr Pro Gln Val Met Pro Cys Thr Pro Glu 
                165                 170                 175     
Phe Tyr Arg Thr His Glu Gln Leu Ala Tyr Lys Leu Lys Ser Gln Pro 
            180                 185                 190         
Arg Gly Leu Ala Leu Ile Leu Ser Asn Ile His Phe Asn Lys Glu Thr 
        195                 200                 205             
Asp Leu Asp Phe Arg Ser Gly Gly Asp Val Asp Asn Thr Ala Leu His 
    210                 215                 220                 
Met Leu Phe Lys His Leu Gly Tyr Gln Val Val Val Arg Gln Asp Arg 
225                 230                 235                 240 
Thr Ala Gln Glu Met Lys Glu Glu Leu Glu Ile Phe Ser Lys His Pro 
                245                 250                 255     
Ala His Arg Asn Val Asp Ser Cys Ile Val Ser Leu Leu Ser His Gly 
            260                 265                 270         
Ile Glu Gly Gly Ile Tyr Gly Ile Asp Gly Lys Leu Leu Gln Leu Gln 
        275                 280                 285             
Glu Ile Phe Arg Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn 
    290                 295                 300                 
Lys Pro Lys Met Phe Phe Val Gln Ala Cys Arg Gly Asp Glu Thr Asp 
305                 310                 315                 320 
His Gly Val Asp Gln Ile Asp Gly Asn Asp Cys Ala Ser Ser Pro Gly 
                325                 330                 335     
Cys Glu Glu Thr Asp Ala Asn Lys Lys Glu Asn Pro Lys Leu Arg Leu 
            340                 345                 350         
Pro Thr Cys Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        355                 360                 365             
Ala Ala Met Arg Asn Thr Lys His Gly Ser Trp Tyr Val Glu Ala Leu 
    370                 375                 380                 
Thr Ser Val Phe Ala Glu Asp Ser Gly His Met His Val Ala Asp Met 
385                 390                 395                 400 
Leu Val Lys Val Asn Arg Leu Ile Lys Leu Arg Glu Gly His Ala Pro 
                405                 410                 415     
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            420                 425                 430         
Leu Cys Gln Asp Leu Tyr Leu Phe Pro Gly Tyr Phe Pro Gly 
        435                 440                 445     

<210> 102
<211> 164
<212> PRT
<213> Anolis carolinensis


<400> 102
Gly Pro His Tyr Pro Gln Val Met Pro Cys Thr Pro Glu Phe Tyr Arg 
1               5                   10                  15      
Thr His Glu Gln Leu Ala Tyr Lys Leu Lys Ser Gln Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Ile Leu Ser Asn Ile His Phe Asn Lys Glu Thr Asp Leu Asp 
        35                  40                  45              
Phe Arg Ser Gly Gly Asp Val Asp Asn Thr Ala Leu His Met Leu Phe 
    50                  55                  60                  
Lys His Leu Gly Tyr Gln Val Val Val Arg Gln Asp Arg Thr Ala Gln 
65                  70                  75                  80  
Glu Met Lys Glu Glu Leu Glu Ile Phe Ser Lys His Pro Ala His Arg 
                85                  90                  95      
Asn Val Asp Ser Cys Ile Val Ser Leu Leu Ser His Gly Ile Glu Gly 
            100                 105                 110         
Gly Ile Tyr Gly Ile Asp Gly Lys Leu Leu Gln Leu Gln Glu Ile Phe 
        115                 120                 125             
Arg Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys 
    130                 135                 140                 
Met Phe Phe Val Gln Ala Cys Arg Gly Asp Glu Thr Asp His Gly Val 
145                 150                 155                 160 
Asp Gln Ile Asp 
                

<210> 103
<211> 105
<212> PRT
<213> Anolis carolinensis


<400> 103
Ala Asn Lys Lys Glu Asn Pro Lys Leu Arg Leu Pro Thr Cys Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys His Gly Ser Trp Tyr Val Glu Ala Leu Thr Ser Val Phe Ala 
        35                  40                  45              
Glu Asp Ser Gly His Met His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Arg Leu Ile Lys Leu Arg Glu Gly His Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Gln Asp Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly Tyr Phe Pro Gly 
            100                 105 

<210> 104
<211> 427
<212> PRT
<213> Alligator


<400> 104
Met Ser Gly Ala Cys Gly Met Gln Pro Cys His Gln Glu Ala Leu Arg 
1               5                   10                  15      
Arg His Arg Val Pro Leu Ala Lys Gln Leu Val Leu Gln Glu Leu Leu 
            20                  25                  30          
Glu His Leu Leu Ala Arg Ala Val Leu Thr Pro Glu Met Lys Glu Ala 
        35                  40                  45              
Ile Gln Thr Lys Ala Gly Ser Phe Ser Gln Asn Val Glu Phe Leu Ser 
    50                  55                  60                  
Leu Leu Pro Lys Arg Gly Pro Gln Ala Phe Ser Ala Phe Cys Glu Ala 
65                  70                  75                  80  
Leu Arg Glu Thr Arg Gln Glu His Leu Glu Glu Met Leu Leu Asn Ala 
                85                  90                  95      
Ile Gln His Ser Ser Asn Gly Tyr Val Lys Arg Gly His Asp Tyr Asp 
            100                 105                 110         
Ser Ser Leu Pro Phe Pro Val Cys Glu Ser Tyr His Leu Ser Lys Arg 
        115                 120                 125             
Pro Arg Cys Ile Glu Pro Phe Glu His Ser Leu Asp Asn Gly Asp Gly 
    130                 135                 140                 
Pro Pro Tyr Pro Gln Val Arg Ala Cys Thr Pro Glu Phe Tyr Arg Thr 
145                 150                 155                 160 
His Gln Arg Leu Ala Tyr Lys Leu Thr Ser Asp Pro Arg Gly Leu Ala 
                165                 170                 175     
Leu Val Leu Ser Asn Val His Phe Asn Gly Glu Lys Asp Leu Glu Phe 
            180                 185                 190         
Arg Ser Gly Gly Asp Val Asp Cys Ala Ala Leu Glu Lys Leu Phe Glu 
        195                 200                 205             
Cys Leu Gly Tyr Lys Val Thr Val His His Asp Gln Ser Ala Gln Glu 
    210                 215                 220                 
Met Gln Glu Thr Leu Gln Lys Phe Ser Gln Lys Pro Thr His Gln Glu 
225                 230                 235                 240 
Val Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Gly 
                245                 250                 255     
Val Tyr Gly Ile Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Arg 
            260                 265                 270         
Leu Phe Asp Asn Ala Asn Cys Leu Asn Leu Gln Asn Lys Pro Lys Met 
        275                 280                 285             
Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp 
    290                 295                 300                 
Gln Arg Asp Gly Lys Glu Arg Ser Asp Ser Pro Gly Tyr Glu Glu Ser 
305                 310                 315                 320 
Asp Ala Asn Lys Glu Glu Asn Pro Arg Leu Arg Leu Pro Thr Cys Ser 
                325                 330                 335     
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            340                 345                 350         
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr Ser Val Phe 
        355                 360                 365             
Ala Glu Asp Ser His Asn Thr His Val Ala Asp Met Leu Val Lys Val 
    370                 375                 380                 
Asn Arg Met Ile Lys His Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
385                 390                 395                 400 
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg Asp 
                405                 410                 415     
Leu Tyr Leu Phe Pro Gly Tyr Leu Pro Gly Asn 
            420                 425         

<210> 105
<211> 164
<212> PRT
<213> Alligator


<400> 105
Gly Pro Pro Tyr Pro Gln Val Arg Ala Cys Thr Pro Glu Phe Tyr Arg 
1               5                   10                  15      
Thr His Gln Arg Leu Ala Tyr Lys Leu Thr Ser Asp Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Val Leu Ser Asn Val His Phe Asn Gly Glu Lys Asp Leu Glu 
        35                  40                  45              
Phe Arg Ser Gly Gly Asp Val Asp Cys Ala Ala Leu Glu Lys Leu Phe 
    50                  55                  60                  
Glu Cys Leu Gly Tyr Lys Val Thr Val His His Asp Gln Ser Ala Gln 
65                  70                  75                  80  
Glu Met Gln Glu Thr Leu Gln Lys Phe Ser Gln Lys Pro Thr His Gln 
                85                  90                  95      
Glu Val Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
            100                 105                 110         
Gly Val Tyr Gly Ile Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
        115                 120                 125             
Arg Leu Phe Asp Asn Ala Asn Cys Leu Asn Leu Gln Asn Lys Pro Lys 
    130                 135                 140                 
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
145                 150                 155                 160 
Asp Gln Arg Asp 
                

<210> 106
<211> 106
<212> PRT
<213> Alligator


<400> 106
Ala Asn Lys Glu Glu Asn Pro Arg Leu Arg Leu Pro Thr Cys Ser Asp 
1               5                   10                  15      
Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg Asn 
            20                  25                  30          
Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Thr Ser Val Phe Ala 
        35                  40                  45              
Glu Asp Ser His Asn Thr His Val Ala Asp Met Leu Val Lys Val Asn 
    50                  55                  60                  
Arg Met Ile Lys His Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe His 
65                  70                  75                  80  
Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg Asp Leu 
                85                  90                  95      
Tyr Leu Phe Pro Gly Tyr Leu Pro Gly Asn 
            100                 105     

<210> 107
<211> 421
<212> PRT
<213> Xenopus <genus>


<400> 107
Met Leu Gly Gly Met Gln Lys His His Lys Asp Ala Leu Gln Arg Leu 
1               5                   10                  15      
Arg Val Thr Leu Leu His Asp Met Ile Ile Glu Glu Leu Val Glu His 
            20                  25                  30          
Leu Val Ser Ser Gly Ile Leu Thr Pro Ile Met His Ser Thr Ile Met 
        35                  40                  45              
Ala His Arg Ser Glu Tyr Lys Gln Asn Val Thr Leu Leu Thr Gln Leu 
    50                  55                  60                  
Pro Lys Arg Gly Pro Arg Ala Phe Ser Glu Phe Cys Asn Ala Leu His 
65                  70                  75                  80  
Ala Thr Gly Gln Arg His Leu Ala Glu Gln Leu Glu Glu Glu Ala Gln 
                85                  90                  95      
Gln Gln Gln Met Glu Ser Val Thr Pro Glu Val His Glu Arg Ser Phe 
            100                 105                 110         
Pro Leu Pro Val Gln Glu Ser Thr Pro Ser Arg Pro Arg Arg Gln Phe 
        115                 120                 125             
Cys Arg Glu Tyr Asn Glu Glu Ser Ile Asp Asp Gly Asp Gly Pro Gly 
    130                 135                 140                 
Thr Val Gln Leu Cys Ser Val Asp Phe Tyr Leu Ser His His Gln Gln 
145                 150                 155                 160 
Ala Tyr Lys Met His Ser Cys Pro Arg Gly Arg Ala Leu Ile Ile Ser 
                165                 170                 175     
Asn Val Ala Phe Glu Thr Gln Asp Leu Asp His Arg Tyr Gly Gly Glu 
            180                 185                 190         
Val Asp Val Thr Ser Leu Glu Lys Leu Phe Ser Ser Leu Gly Phe Gln 
        195                 200                 205             
Val Glu Val Arg Arg Asn Leu Asn Ala Gln Asn Met Met Ser Gln Leu 
    210                 215                 220                 
Gly Ala Phe Ser Ala Leu Pro Ala His Ser Ala Leu Asp Ser Cys Val 
225                 230                 235                 240 
Val Ala Val Leu Ser His Gly Leu Asp Gly Ala Val Tyr Gly Thr Asp 
                245                 250                 255     
Gly Lys Leu Val Gln Leu Gln Asp Val Phe Thr Ala Met Asp Asn Ala 
            260                 265                 270         
His Cys Pro Gln Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala 
        275                 280                 285             
Cys Arg Gly Glu Glu Ala Asp Arg Gly Val Asp Gln Arg Asp Gly Arg 
    290                 295                 300                 
Glu Gln Ser Ala Ser Pro Gly Cys Glu Gln Ser Asp Ala Gly Arg Glu 
305                 310                 315                 320 
Asp Ile Lys Val Arg Leu Pro Thr Gln Ser Asp Met Ile Cys Ala Tyr 
                325                 330                 335     
Ala Cys Leu Lys Gly Thr Val Ser Leu Arg Asn Thr Lys Arg Gly Ser 
            340                 345                 350         
Trp Phe Val Gln Asp Leu Val Ser Val Phe Ser Gln Tyr Ser Lys Asn 
        355                 360                 365             
Thr His Val Ala Asp Met Leu Val Lys Val Asn Ala Leu Ile Lys Glu 
    370                 375                 380                 
Arg Glu Gly His Ala Pro Gly Thr Glu Phe His Arg Cys Lys Glu Met 
385                 390                 395                 400 
Ser Glu Tyr Cys Ser Thr Leu Cys Arg Asp Leu Tyr Leu Phe Pro Gly 
                405                 410                 415     
Ile Gly Pro Pro Lys 
            420     

<210> 108
<211> 161
<212> PRT
<213> Xenopus <genus>


<400> 108
Gly Pro Gly Thr Val Gln Leu Cys Ser Val Asp Phe Tyr Leu Ser His 
1               5                   10                  15      
His Gln Gln Ala Tyr Lys Met His Ser Cys Pro Arg Gly Arg Ala Leu 
            20                  25                  30          
Ile Ile Ser Asn Val Ala Phe Glu Thr Gln Asp Leu Asp His Arg Tyr 
        35                  40                  45              
Gly Gly Glu Val Asp Val Thr Ser Leu Glu Lys Leu Phe Ser Ser Leu 
    50                  55                  60                  
Gly Phe Gln Val Glu Val Arg Arg Asn Leu Asn Ala Gln Asn Met Met 
65                  70                  75                  80  
Ser Gln Leu Gly Ala Phe Ser Ala Leu Pro Ala His Ser Ala Leu Asp 
                85                  90                  95      
Ser Cys Val Val Ala Val Leu Ser His Gly Leu Asp Gly Ala Val Tyr 
            100                 105                 110         
Gly Thr Asp Gly Lys Leu Val Gln Leu Gln Asp Val Phe Thr Ala Met 
        115                 120                 125             
Asp Asn Ala His Cys Pro Gln Leu Gln Asn Lys Pro Lys Met Phe Phe 
    130                 135                 140                 
Ile Gln Ala Cys Arg Gly Glu Glu Ala Asp Arg Gly Val Asp Gln Arg 
145                 150                 155                 160 
Asp 
    

<210> 109
<211> 105
<212> PRT
<213> Xenopus <genus>


<400> 109
Ala Gly Arg Glu Asp Ile Lys Val Arg Leu Pro Thr Gln Ser Asp Met 
1               5                   10                  15      
Ile Cys Ala Tyr Ala Cys Leu Lys Gly Thr Val Ser Leu Arg Asn Thr 
            20                  25                  30          
Lys Arg Gly Ser Trp Phe Val Gln Asp Leu Val Ser Val Phe Ser Gln 
        35                  40                  45              
Tyr Ser Lys Asn Thr His Val Ala Asp Met Leu Val Lys Val Asn Ala 
    50                  55                  60                  
Leu Ile Lys Glu Arg Glu Gly His Ala Pro Gly Thr Glu Phe His Arg 
65                  70                  75                  80  
Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg Asp Leu Tyr 
                85                  90                  95      
Leu Phe Pro Gly Ile Gly Pro Pro Lys 
            100                 105 

<210> 110
<211> 435
<212> PRT
<213> Danio


<400> 110
Met Leu Gly Glu Cys Gly Met Thr Lys Trp Glu Arg Leu Ala Leu Arg 
1               5                   10                  15      
Arg Asn Ser Val Lys Met Leu Gln Asp Leu Val Val Asp Asp Leu Leu 
            20                  25                  30          
Ile Gln Cys Leu Gln Gln Asp Gly Ile Leu Thr Asp Ser Met Ala Glu 
        35                  40                  45              
Ser Ile Met Ala Lys Pro Thr Ser Gln Gly Arg Ser His Gln Leu Leu 
    50                  55                  60                  
Phe Leu Leu Pro Lys Arg Gly Pro Arg Ala Phe Ser Thr Phe Cys Ser 
65                  70                  75                  80  
Ala Leu Lys Glu Thr Glu Gln His His Leu Cys Lys Leu Leu Met Asp 
                85                  90                  95      
Phe Thr Glu Lys Asp Lys Cys Phe Ser Glu Pro Ser Leu Ser Leu Pro 
            100                 105                 110         
Thr Gln Glu Cys Val Thr Pro Ala Lys Arg Pro Arg Thr His Glu Ser 
        115                 120                 125             
Met Glu Met Cys Leu Asp Ala Asp Ser Pro Val Thr Thr Ala Val Leu 
    130                 135                 140                 
Pro Cys Thr Pro Glu Phe Tyr Gln Ser His Arg Pro Gln Ala Tyr Pro 
145                 150                 155                 160 
Met Arg Ser Cys Pro Arg Gly Leu Ala Leu Val Leu Ser Asn Val Arg 
                165                 170                 175     
Phe Asp Ser Ala Asn Thr Asp Leu Asp Ile Arg Arg Gly Gly Glu Val 
            180                 185                 190         
Asp Glu Glu Thr Leu Arg Arg Leu Phe Thr Glu Leu Asp Phe Lys Val 
        195                 200                 205             
Ser Leu His Arg Asp Leu Thr Ala Glu Ala Met Arg Arg Cys Leu Glu 
    210                 215                 220                 
Gln Phe Ala Gln Gln Gln Glu His Ala Ala Tyr Asp Cys Ala Val Val 
225                 230                 235                 240 
Cys Leu Leu Ser His Gly Val Glu Gly Ser Val Tyr Gly Thr Asp Gly 
                245                 250                 255     
Gln Leu Leu Glu Leu Asp Trp Val Phe Glu Val Phe Asp Asn Ala Arg 
            260                 265                 270         
Cys Pro Leu Leu Gln Asn Lys Pro Lys Met Phe Phe Ile Gln Ala Cys 
        275                 280                 285             
Arg Gly Glu Glu Met Asp Asn Gly Val Asp Gln Leu Asp Gly Gln Glu 
    290                 295                 300                 
Arg Thr Gln Ser Pro Gly Cys Glu Gln Arg Asp Ala Gly Arg Glu Gly 
305                 310                 315                 320 
Glu Arg Asp Asn Arg Glu Lys Lys Glu Glu Lys Glu Arg Glu Arg Leu 
                325                 330                 335     
Arg Val Lys Leu Pro Gln Arg Ser Asp Met Ile Cys Gly Phe Ala Thr 
            340                 345                 350         
Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys Lys Gly Ser Trp Phe 
        355                 360                 365             
Ile Gln Glu Leu Asn Thr Ala Ile Arg Gln Arg Ala Asn Asn Thr His 
    370                 375                 380                 
Leu Ser Asp Ile Leu Val Gln Val Asn Gly Gln Ile Lys Ser Arg Glu 
385                 390                 395                 400 
Gly Tyr Ala Pro Gly Ser Ala His His Arg Cys Lys Glu Met Ser Glu 
                405                 410                 415     
Phe Thr Ser Ser Leu Cys Lys Asp Leu Tyr Leu Phe Pro Lys Tyr Tyr 
            420                 425                 430         
Pro Ser Asn 
        435 

<210> 111
<211> 165
<212> PRT
<213> Danio


<400> 111
Ser Pro Val Thr Thr Ala Val Leu Pro Cys Thr Pro Glu Phe Tyr Gln 
1               5                   10                  15      
Ser His Arg Pro Gln Ala Tyr Pro Met Arg Ser Cys Pro Arg Gly Leu 
            20                  25                  30          
Ala Leu Val Leu Ser Asn Val Arg Phe Asp Ser Ala Asn Thr Asp Leu 
        35                  40                  45              
Asp Ile Arg Arg Gly Gly Glu Val Asp Glu Glu Thr Leu Arg Arg Leu 
    50                  55                  60                  
Phe Thr Glu Leu Asp Phe Lys Val Ser Leu His Arg Asp Leu Thr Ala 
65                  70                  75                  80  
Glu Ala Met Arg Arg Cys Leu Glu Gln Phe Ala Gln Gln Gln Glu His 
                85                  90                  95      
Ala Ala Tyr Asp Cys Ala Val Val Cys Leu Leu Ser His Gly Val Glu 
            100                 105                 110         
Gly Ser Val Tyr Gly Thr Asp Gly Gln Leu Leu Glu Leu Asp Trp Val 
        115                 120                 125             
Phe Glu Val Phe Asp Asn Ala Arg Cys Pro Leu Leu Gln Asn Lys Pro 
    130                 135                 140                 
Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Glu Glu Met Asp Asn Gly 
145                 150                 155                 160 
Val Asp Gln Leu Asp 
                165 

<210> 112
<211> 120
<212> PRT
<213> Danio


<400> 112
Ala Gly Arg Glu Gly Glu Arg Asp Asn Arg Glu Lys Lys Glu Glu Lys 
1               5                   10                  15      
Glu Arg Glu Arg Leu Arg Val Lys Leu Pro Gln Arg Ser Asp Met Ile 
            20                  25                  30          
Cys Gly Phe Ala Thr Leu Lys Gly Thr Ala Ala Met Arg Asn Thr Lys 
        35                  40                  45              
Lys Gly Ser Trp Phe Ile Gln Glu Leu Asn Thr Ala Ile Arg Gln Arg 
    50                  55                  60                  
Ala Asn Asn Thr His Leu Ser Asp Ile Leu Val Gln Val Asn Gly Gln 
65                  70                  75                  80  
Ile Lys Ser Arg Glu Gly Tyr Ala Pro Gly Ser Ala His His Arg Cys 
                85                  90                  95      
Lys Glu Met Ser Glu Phe Thr Ser Ser Leu Cys Lys Asp Leu Tyr Leu 
            100                 105                 110         
Phe Pro Lys Tyr Tyr Pro Ser Asn 
        115                 120 

<210> 113
<211> 417
<212> PRT
<213> Callorhinchus milii


<400> 113
Met Lys Gly Lys Trp Glu Met Lys Ser Ala Glu Ser Glu Ala Leu Arg 
1               5                   10                  15      
Lys Val His Val Thr Leu Ala Lys Gln Leu Val Ser Thr Glu Ile Val 
            20                  25                  30          
His His Leu Leu Ser Ala Glu Ile Leu Thr Glu Glu Met Val Asp Leu 
        35                  40                  45              
Leu Glu Thr Cys Arg Gly Thr Phe Gln Lys Asn Thr Glu Leu Leu Arg 
    50                  55                  60                  
Leu Leu Pro Lys Arg Gly Pro Arg Ala Phe Glu Glu Phe Cys Arg Ala 
65                  70                  75                  80  
Leu Asp Arg Thr Lys Gln Ser His Leu Thr Gly Leu Leu Arg Glu Ser 
                85                  90                  95      
Val Thr Glu Glu Glu Ala Leu Cys Lys Pro Thr Gln Glu Ser Glu Cys 
            100                 105                 110         
Val Thr Pro Ala Lys Lys Phe Cys Ser Leu Trp Arg Val Cys Leu Asp 
        115                 120                 125             
Ala Gly Asp Gly Ser Gly Thr Phe Ser Val Arg Pro Thr Thr Ala Gln 
    130                 135                 140                 
Phe Tyr His Glu His His Lys Gln Ser Tyr Arg Met Ala Ser Arg Pro 
145                 150                 155                 160 
Arg Gly Ala Ala Leu Ile Val Ser Asn Glu Val Phe Val Gly Glu Gly 
                165                 170                 175     
Leu Gly His Arg Pro Gly Gly Ala Ala Asp Thr Gly Val Leu Arg Ala 
            180                 185                 190         
Leu Leu Ser Gln Leu Gly Tyr Arg Val Thr Ser Val Cys Asn Ser Pro 
        195                 200                 205             
Ala Gln Glu Leu Glu Thr Arg Leu Arg Asp Phe Ala Leu Ser Ala Asp 
    210                 215                 220                 
His Arg Arg Thr Asp Ser Cys Val Val Val Leu Leu Ser His Gly Val 
225                 230                 235                 240 
Glu Gly Ala Ile Tyr Gly Val Asp Gly Lys Leu Val Gln Ile His Asp 
                245                 250                 255     
Ile Phe Gln Leu Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys 
            260                 265                 270         
Pro Lys Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Arg Thr Asp Arg 
        275                 280                 285             
Gly Val Asp Arg Leu Asp Gly Ala Asp Ala Pro Gly Cys Glu Glu Cys 
    290                 295                 300                 
Asp Ala Gly Lys Glu Arg Glu Arg Thr Arg Arg Gly Lys Leu Pro Thr 
305                 310                 315                 320 
Gln Ser Asp Ile Ile Cys Gly Tyr Ala Cys Leu Arg Gly Thr Ala Ala 
                325                 330                 335     
Leu Arg Asn Thr Arg Gln Gly Ser Trp Tyr Ile Gln Ala Leu Val Lys 
            340                 345                 350         
Val Phe Thr Glu Arg Ala His Asn Thr His Val Ala Asp Met Leu Val 
        355                 360                 365             
Gln Val Asn Ala Val Ile Arg Asp Arg Glu Gly Phe Ala Pro Gly Thr 
    370                 375                 380                 
Asp Phe His Arg Cys Lys Glu Met Ala Glu Tyr Ser Ile Phe Glu Glu 
385                 390                 395                 400 
Met Glu Gly Glu Thr Gln Arg Lys Gln Arg Arg Arg Lys Thr Ala Ala 
                405                 410                 415     
Pro 
    

<210> 114
<211> 162
<212> PRT
<213> Callorhinchus milii


<400> 114
Ser Gly Thr Phe Ser Val Arg Pro Thr Thr Ala Gln Phe Tyr His Glu 
1               5                   10                  15      
His His Lys Gln Ser Tyr Arg Met Ala Ser Arg Pro Arg Gly Ala Ala 
            20                  25                  30          
Leu Ile Val Ser Asn Glu Val Phe Val Gly Glu Gly Leu Gly His Arg 
        35                  40                  45              
Pro Gly Gly Ala Ala Asp Thr Gly Val Leu Arg Ala Leu Leu Ser Gln 
    50                  55                  60                  
Leu Gly Tyr Arg Val Thr Ser Val Cys Asn Ser Pro Ala Gln Glu Leu 
65                  70                  75                  80  
Glu Thr Arg Leu Arg Asp Phe Ala Leu Ser Ala Asp His Arg Arg Thr 
                85                  90                  95      
Asp Ser Cys Val Val Val Leu Leu Ser His Gly Val Glu Gly Ala Ile 
            100                 105                 110         
Tyr Gly Val Asp Gly Lys Leu Val Gln Ile His Asp Ile Phe Gln Leu 
        115                 120                 125             
Phe Asp Asn Ala Asn Cys Pro Asn Leu Gln Asn Lys Pro Lys Met Phe 
    130                 135                 140                 
Phe Ile Gln Ala Cys Arg Gly Asp Arg Thr Asp Arg Gly Val Asp Arg 
145                 150                 155                 160 
Leu Asp 
        

<210> 115
<211> 112
<212> PRT
<213> Callorhinchus milii


<400> 115
Ala Gly Lys Glu Arg Glu Arg Thr Arg Arg Gly Lys Leu Pro Thr Gln 
1               5                   10                  15      
Ser Asp Ile Ile Cys Gly Tyr Ala Cys Leu Arg Gly Thr Ala Ala Leu 
            20                  25                  30          
Arg Asn Thr Arg Gln Gly Ser Trp Tyr Ile Gln Ala Leu Val Lys Val 
        35                  40                  45              
Phe Thr Glu Arg Ala His Asn Thr His Val Ala Asp Met Leu Val Gln 
    50                  55                  60                  
Val Asn Ala Val Ile Arg Asp Arg Glu Gly Phe Ala Pro Gly Thr Asp 
65                  70                  75                  80  
Phe His Arg Cys Lys Glu Met Ala Glu Tyr Ser Ile Phe Glu Glu Met 
                85                  90                  95      
Glu Gly Glu Thr Gln Arg Lys Gln Arg Arg Arg Lys Thr Ala Ala Pro 
            100                 105                 110         



<210> 116
<211> 351
<212> PRT
<213> Ascidiacea


<400> 116
Met Asp Asp Ala Pro Ser Pro Thr Asp Ser Leu Ser Asn Ile Arg Ser 
1               5                   10                  15      
Thr Ala Ser Val His Ser Leu Phe Ser Arg Ser Asp Val Arg Thr Gln 
            20                  25                  30          
Ser Asn Thr Ala Ile Asn His Ile Asn Thr Val Gln Ser Pro Thr Ser 
        35                  40                  45              
Thr Lys Ala Ala Thr Ser Tyr Gln Ile Asn Leu His Gln Gly Met Asp 
    50                  55                  60                  
Leu Phe Asp Gly Pro Thr Val Ser Asp Leu Thr Val Arg Lys Ser Thr 
65                  70                  75                  80  
His Gln His Leu Met Gln His Thr Asp Cys Tyr Gln Met Thr Met Arg 
                85                  90                  95      
Gly Arg Pro Lys Gly Ala Ala Leu Ile Ile Ser Val Glu Lys Phe His 
            100                 105                 110         
Pro Glu Ser Asp Leu Leu Asn Arg Glu Gly Ser Glu Lys Asp Arg Val 
        115                 120                 125             
Arg Leu Glu Leu Val Leu Gln Gln Ile Gly Phe Gln Cys Tyr Val Leu 
    130                 135                 140                 
Ile Asn Gly Thr Ala Glu Gln Ile Val Ser Thr Leu Gln Thr Phe Ala 
145                 150                 155                 160 
Glu Leu Glu Glu His Tyr Tyr Asn Ser Cys Ser Leu Val Ala Ala Met 
                165                 170                 175     
Ser His Gly Asp Ala Gly Cys Phe Tyr Gly Ser Asp Gly Val Ser Val 
            180                 185                 190         
Ala Ile Asp Thr Val Val Asn Phe Phe Ser Asn Gln Asn Cys His Ser 
        195                 200                 205             
Leu Gln Lys Lys Pro Lys Ile Phe Leu Phe Gln Ala Cys Gln Gly Asp 
    210                 215                 220                 
Glu Tyr Asp Met Gly Val Asp Glu Val Asp Gly Pro Val Gln Ala Pro 
225                 230                 235                 240 
Val Gly Asp Val Asp Asn Thr Ser Thr Ser Ser Ser Asn Asp His Ile 
                245                 250                 255     
Arg Asn Lys Leu Pro Gln Lys Ser Asp Met Leu Ile Gly Gln Ala Thr 
            260                 265                 270         
Met Lys Gly Phe Ala Ala Met Arg Asn Thr Lys His Gly Ser Trp Tyr 
        275                 280                 285             
Ile Gln Ala Phe Val Arg Val Leu Ala Arg His Ala Cys Asp Thr Asp 
    290                 295                 300                 
Leu Leu Asp Met Met Thr Lys Val Asn Asn Ile Leu Lys His Lys Glu 
305                 310                 315                 320 
Gly Trp Cys Pro Gly Ser Val Tyr His Arg Cys Lys Val Met Pro Glu 
                325                 330                 335     
Phe Lys Ser Ser Leu Ser Lys Lys Leu Tyr Phe Phe Pro Gly Ile 
            340                 345                 350     

<210> 117
<211> 167
<212> PRT
<213> Ascidiacea


<400> 117
Gly Pro Thr Val Ser Asp Leu Thr Val Arg Lys Ser Thr His Gln His 
1               5                   10                  15      
Leu Met Gln His Thr Asp Cys Tyr Gln Met Thr Met Arg Gly Arg Pro 
            20                  25                  30          
Lys Gly Ala Ala Leu Ile Ile Ser Val Glu Lys Phe His Pro Glu Ser 
        35                  40                  45              
Asp Leu Leu Asn Arg Glu Gly Ser Glu Lys Asp Arg Val Arg Leu Glu 
    50                  55                  60                  
Leu Val Leu Gln Gln Ile Gly Phe Gln Cys Tyr Val Leu Ile Asn Gly 
65                  70                  75                  80  
Thr Ala Glu Gln Ile Val Ser Thr Leu Gln Thr Phe Ala Glu Leu Glu 
                85                  90                  95      
Glu His Tyr Tyr Asn Ser Cys Ser Leu Val Ala Ala Met Ser His Gly 
            100                 105                 110         
Asp Ala Gly Cys Phe Tyr Gly Ser Asp Gly Val Ser Val Ala Ile Asp 
        115                 120                 125             
Thr Val Val Asn Phe Phe Ser Asn Gln Asn Cys His Ser Leu Gln Lys 
    130                 135                 140                 
Lys Pro Lys Ile Phe Leu Phe Gln Ala Cys Gln Gly Asp Glu Tyr Asp 
145                 150                 155                 160 
Met Gly Val Asp Glu Val Asp 
                165         

<210> 118
<211> 106
<212> PRT
<213> Ascidiacea


<400> 118
Asn Thr Ser Thr Ser Ser Ser Asn Asp His Ile Arg Asn Lys Leu Pro 
1               5                   10                  15      
Gln Lys Ser Asp Met Leu Ile Gly Gln Ala Thr Met Lys Gly Phe Ala 
            20                  25                  30          
Ala Met Arg Asn Thr Lys His Gly Ser Trp Tyr Ile Gln Ala Phe Val 
        35                  40                  45              
Arg Val Leu Ala Arg His Ala Cys Asp Thr Asp Leu Leu Asp Met Met 
    50                  55                  60                  
Thr Lys Val Asn Asn Ile Leu Lys His Lys Glu Gly Trp Cys Pro Gly 
65                  70                  75                  80  
Ser Val Tyr His Arg Cys Lys Val Met Pro Glu Phe Lys Ser Ser Leu 
                85                  90                  95      
Ser Lys Lys Leu Tyr Phe Phe Pro Gly Ile 
            100                 105     

<210> 119
<211> 15
<212> PRT
<213> Homo sapiens


<400> 119
Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His 
1               5                   10                  15  

<210> 120
<211> 15
<212> PRT
<213> Mus <mouse, genus>


<400> 120
Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His 
1               5                   10                  15  

<210> 121
<211> 15
<212> PRT
<213> Ovis


<400> 121
Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His 
1               5                   10                  15  

<210> 122
<211> 15
<212> PRT
<213> Sarcophilus harrisii


<400> 122
Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His 
1               5                   10                  15  

<210> 123
<211> 15
<212> PRT
<213> Gallus


<400> 123
Ser Glu Lys Asp Leu Glu Tyr Arg Ser Gly Gly Asp Val Asp Cys 
1               5                   10                  15  

<210> 124
<211> 15
<212> PRT
<213> Anolis carolinensis


<400> 124
Lys Glu Thr Asp Leu Asp Phe Arg Ser Gly Gly Asp Val Asp Asn 
1               5                   10                  15  

<210> 125
<211> 15
<212> PRT
<213> Alligator


<400> 125
Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp Cys 
1               5                   10                  15  

<210> 126
<211> 14
<212> PRT
<213> Xenopus <genus>


<400> 126
Thr Gln Asp Leu Asp His Arg Tyr Gly Gly Glu Val Asp Val 
1               5                   10                  

<210> 127
<211> 16
<212> PRT
<213> Danio


<400> 127
Ser Ala Asn Thr Asp Leu Asp Ile Arg Arg Gly Gly Glu Val Asp Glu 
1               5                   10                  15      



<210> 128
<211> 14
<212> PRT
<213> Callorhinchus milii


<400> 128
Gly Glu Gly Leu Gly His Arg Pro Gly Gly Ala Ala Asp Thr 
1               5                   10                  

<210> 129
<211> 15
<212> PRT
<213> Ascidiacea


<400> 129
Pro Glu Ser Asp Leu Leu Asn Arg Glu Gly Ser Glu Lys Asp Arg 
1               5                   10                  15  

<210> 130
<211> 15
<212> PRT
<213> Homo sapiens


<400> 130
Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
1               5                   10                  15  

<210> 131
<211> 15
<212> PRT
<213> Mus <mouse, genus>


<400> 131
Leu Leu Ser His Gly Val Glu Gly Gly Ile Tyr Gly Val Asp Gly 
1               5                   10                  15  

<210> 132
<211> 15
<212> PRT
<213> Ovis


<400> 132
Leu Leu Ser His Gly Val Glu Gly Ser Val Tyr Gly Val Asp Gly 
1               5                   10                  15  

<210> 133
<211> 15
<212> PRT
<213> Sarcophilus harrisii


<400> 133
Leu Leu Ser His Gly Ile Glu Gly Gly Ile Tyr Gly Val Asp Gly 
1               5                   10                  15  

<210> 134
<211> 15
<212> PRT
<213> Ovis


<400> 134
Leu Leu Ser His Gly Val Glu Gly Gly Val Tyr Gly Thr Asp Gly 
1               5                   10                  15  

<210> 135
<211> 15
<212> PRT
<213> Anolis


<400> 135
Leu Leu Ser His Gly Ile Glu Gly Gly Ile Tyr Gly Ile Asp Gly 
1               5                   10                  15  

<210> 136
<211> 15
<212> PRT
<213> Alligator


<400> 136
Leu Leu Ser His Gly Val Glu Gly Gly Val Tyr Gly Ile Asp Gly 
1               5                   10                  15  

<210> 137
<211> 15
<212> PRT
<213> Xenopus <genus>


<400> 137
Val Leu Ser His Gly Leu Asp Gly Ala Val Tyr Gly Thr Asp Gly 
1               5                   10                  15  

<210> 138
<211> 15
<212> PRT
<213> Danio


<400> 138
Leu Leu Ser His Gly Val Glu Gly Ser Val Tyr Gly Thr Asp Gly 
1               5                   10                  15  

<210> 139
<211> 15
<212> PRT
<213> Callorhinchus milii


<400> 139
Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly Val Asp Gly 
1               5                   10                  15  

<210> 140
<211> 15
<212> PRT
<213> Ascidiacea


<400> 140
Ala Met Ser His Gly Asp Ala Gly Cys Phe Tyr Gly Ser Asp Gly 
1               5                   10                  15  

<210> 141
<211> 8
<212> PRT
<213> Homo sapiens


<400> 141
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 142
<211> 8
<212> PRT
<213> Mus <mouse, genus>


<400> 142
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 143
<211> 8
<212> PRT
<213> Ovis


<400> 143
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 144
<211> 8
<212> PRT
<213> Sarcophilus harrisii


<400> 144
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 145
<211> 8
<212> PRT
<213> Gallus


<400> 145
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 146
<211> 8
<212> PRT
<213> Anolis


<400> 146
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 147
<211> 8
<212> PRT
<213> Alligator


<400> 147
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 148
<211> 8
<212> PRT
<213> Xenopus <genus>


<400> 148
Gln Ala Cys Arg Gly Glu Glu Ala 
1               5               

<210> 149
<211> 8
<212> PRT
<213> Danio


<400> 149
Gln Ala Cys Arg Gly Glu Glu Met 
1               5               

<210> 150
<211> 8
<212> PRT
<213> Callorhinchus milii


<400> 150
Gln Ala Cys Arg Gly Asp Arg Thr 
1               5               

<210> 151
<211> 8
<212> PRT
<213> Ascidiacea


<400> 151
Gln Ala Cys Gln Gly Asp Glu Tyr 
1               5               

<210> 152
<211> 8
<212> PRT
<213> Homo sapiens


<400> 152
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 153
<211> 8
<212> PRT
<213> Mus <mouse, genus>


<400> 153
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 154
<211> 8
<212> PRT
<213> Ovis


<400> 154
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 155
<211> 8
<212> PRT
<213> Sarcophilus harrisii


<400> 155
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 156
<211> 8
<212> PRT
<213> Gallus


<400> 156
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 157
<211> 8
<212> PRT
<213> Anolis


<400> 157
Ala Ala Met Arg Asn Thr Lys His 
1               5               

<210> 158
<211> 8
<212> PRT
<213> Alligator


<400> 158
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 159
<211> 8
<212> PRT
<213> Xenopus <genus>


<400> 159
Val Ser Leu Arg Asn Thr Lys Arg 
1               5               

<210> 160
<211> 8
<212> PRT
<213> Danio


<400> 160
Ala Ala Met Arg Asn Thr Lys Lys 
1               5               

<210> 161
<211> 8
<212> PRT
<213> Callorhinchus milii


<400> 161
Ala Ala Leu Arg Asn Thr Arg Gln 
1               5               

<210> 162
<211> 8
<212> PRT
<213> Ascidiacea


<400> 162
Ala Ala Met Arg Asn Thr Lys His 
1               5               

<210> 163
<211> 13
<212> PRT
<213> Homo sapiens


<400> 163
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 164
<211> 13
<212> PRT
<213> Mus <mouse, genus>


<400> 164
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 165
<211> 13
<212> PRT
<213> Ovis


<400> 165
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 166
<211> 13
<212> PRT
<213> Sarcophilus harrisii


<400> 166
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 167
<211> 13
<212> PRT
<213> Gallus


<400> 167
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 168
<211> 13
<212> PRT
<213> Anolis


<400> 168
Glu Gly His Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 169
<211> 13
<212> PRT
<213> Alligator


<400> 169
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 170
<211> 13
<212> PRT
<213> Xenopus <genus>


<400> 170
Glu Gly His Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 171
<211> 13
<212> PRT
<213> Danio


<400> 171
Glu Gly Tyr Ala Pro Gly Ser Ala His His Arg Cys Lys 
1               5                   10              

<210> 172
<211> 13
<212> PRT
<213> Callorhinchus milii


<400> 172
Glu Gly Phe Ala Pro Gly Thr Asp Phe His Arg Cys Lys 
1               5                   10              

<210> 173
<211> 13
<212> PRT
<213> Ascidiacea


<400> 173
Glu Gly Trp Cys Pro Gly Ser Val Tyr His Arg Cys Lys 
1               5                   10              

<210> 174
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 174
Gly Glu Lys Asp Leu Glu Phe Arg Ser Gly Gly Asp Val Asp His 
1               5                   10                  15  

<210> 175
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 10..10
<223> X can be any amino acid

<400> 175
Leu Leu Ser His Gly Val Glu Gly Gly Xaa Tyr Gly Val Asp Gly 
1               5                   10                  15  

<210> 176
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 176
Gln Ala Cys Arg Gly Asp Glu Thr 
1               5               

<210> 177
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 177
Ala Ala Met Arg Asn Thr Lys Arg 
1               5               

<210> 178
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 178
Glu Gly Tyr Ala Pro Gly Thr Glu Phe His Arg Cys Lys 
1               5                   10              

<210> 179
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 179
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Asp Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 180
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 180
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 181
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 181
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Val Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 182
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 182
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Glu Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 183
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 183
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Thr Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 184
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 184
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Gly Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 185
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 185
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Glu Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 186
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 186
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp Ala Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 187
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 187
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Met Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 188
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 188
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Glu Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 189
<211> 272
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 189
Met Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu Pro Thr Arg Ser 
1               5                   10                  15      
Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr Ala Ala Met Arg 
            20                  25                  30          
Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu Ala Gln Val Phe 
        35                  40                  45              
Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met Leu Val Lys Val 
    50                  55                  60                  
Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro Gly Thr Glu Phe 
65                  70                  75                  80  
His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr Leu Cys Arg His 
                85                  90                  95      
Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser Gly Pro Val Cys 
            100                 105                 110         
Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln Thr His Phe Gln 
        115                 120                 125             
Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu Ala Leu Val Leu 
    130                 135                 140                 
Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu Phe Arg Ser Gly 
145                 150                 155                 160 
Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe Lys Leu Leu Gly 
                165                 170                 175     
Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln Glu Met Gln Glu 
            180                 185                 190         
Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg Val Thr Asp Ser 
        195                 200                 205             
Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly Ala Ile Tyr Gly 
    210                 215                 220                 
Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe Gln Leu Phe Asp 
225                 230                 235                 240 
Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys Met Phe Phe Ile 
                245                 250                 255     
Gln Ala Cys Arg Gly Asp Glu Thr Tyr Arg Gly Val Asp Gln Gln Asp 
            260                 265                 270         



<210> 190
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 190
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Asp Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 191
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 191
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Glu Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 192
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 192
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Gly Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 193
<211> 197
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 193
Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Gly 
1               5                   10                  15      
Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln Gly 
            20                  25                  30          
Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val Trp 
        35                  40                  45              
Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val His 
    50                  55                  60                  
Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His Phe 
65                  70                  75                  80  
Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg His 
                85                  90                  95      
Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala Asp 
            100                 105                 110         
Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys Ile 
        115                 120                 125             
Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly Lys 
    130                 135                 140                 
Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg Leu 
145                 150                 155                 160 
Ala Cys Gly Val Ile Gly Thr Ala Gln Val Asp Asp Tyr Lys Asp Asp 
                165                 170                 175     
Asp Asp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Ser His 
            180                 185                 190         
Pro Gln Phe Glu Lys 
        195         

<210> 194
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 3..4
<223> X can be any amino acid

<220> 
<221> SITE
<222> 7..9
<223> X can be any amino acid

<400> 194
Glu Gly Xaa Xaa Pro Gly Xaa Xaa Xaa His Arg Cys Lys 
1               5                   10              

<210> 195
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1..3
<223> X can be any amino acid

<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 5..6
<223> X can be any amino acid

<220> 
<221> SITE
<222> 8..8
<223> X can be any amino acid

<220> 
<221> SITE
<222> 10..12
<223> X can be any amino acid

<220> 
<221> SITE
<222> 14..14
<223> X can be any amino acid

<400> 195
Xaa Xaa Xaa Leu Xaa Xaa Arg Xaa Gly Xaa Xaa Xaa Asp Xaa 
1               5                   10                  

<210> 196
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1..2
<223> X can be any amino acid

<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 6..7
<223> X can be any amino acid

<220> 
<221> SITE
<222> 9..10
<223> X can be any amino acid

<220> 
<221> SITE
<222> 13..13
<223> X can be any amino acid

<400> 196
Xaa Xaa Ser His Gly Xaa Xaa Gly Xaa Xaa Tyr Gly Xaa Asp Gly 
1               5                   10                  15  

<210> 197
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 4..4
<223> X can be any amino acid

<220> 
<221> SITE
<222> 6..8
<223> X can be any amino acid

<400> 197
Gln Ala Cys Xaa Gly Xaa Xaa Xaa 
1               5               

<210> 198
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 198
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Ser Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 199
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> caspase 2

<400> 199
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Ser Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 200
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1..3
<223> X can be any amino acid

<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 7..8
<223> X can be any amino acid

<400> 200
Xaa Xaa Xaa Arg Asn Thr Xaa Xaa 
1               5               

<210> 201
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1..1
<223> X can be any amino acid

<220> 
<223> recognition site

<220> 
<221> SITE
<222> 3..4
<223> X can be any amino acid

<400> 201
Xaa Asp Xaa Xaa Asp 
1               5   

<210> 202
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<220> 
<221> SITE
<222> 3..3
<223> X can be any amino acid

<400> 202
Asp Glu Xaa Asp 
1               

<210> 203
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<220> 
<221> SITE
<222> 3..3
<223> X can be any amino acid

<400> 203
Asp Val Xaa Asp 
1               

<210> 204
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 204
Leu Asp Glu Ser Asp 
1               5   

<210> 205
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 205
Asp Val Ala Asp 
1               

<210> 206
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 206
Asp Glu Val Asp 
1               

<210> 207
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 207
Asp Glu Val Glu 
1               

<210> 208
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 208
Ala Asp Val Ala Asp 
1               5   

<210> 209
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 209
Val Asp Thr Thr Asp 
1               5   

<210> 210
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 210
Asp Thr Thr Asp 
1               

<210> 211
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 211
Asp Val Pro Asp 
1               

<210> 212
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 212
Val Asp Val Pro Asp 
1               5   

<210> 213
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 213
Val Asp Gln Gln Asp 
1               5   

<210> 214
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 214
Thr Asp Thr Ser Asp 
1               5   

<210> 215
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 215
Asp Arg Lys Asp 
1               

<210> 216
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 216
Asp Ala Val Asp 
1               

<210> 217
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 217
Val Lys Val Asp 
1               

<210> 218
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 218
Asp Thr Leu Asp 
1               

<210> 219
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 219
Glu Glu Pro Asp 
1               

<210> 220
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 220
Asp Glu Thr Asp 
1               

<210> 221
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 221
Asp Ala Thr Asp 
1               

<210> 222
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 222
Asn Lys Val Asp 
1               

<210> 223
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 223
Asp Ala Leu Asp 
1               

<210> 224
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 224
Asp Ser Val Asp 
1               

<210> 225
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 225
Asn Ala Ile Asp 
1               

<210> 226
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 226
Asp Lys Pro Asp 
1               

<210> 227
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 227
Ile Gln Leu Asp 
1               

<210> 228
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 228
Asp Asn Ala Asp 
1               

<210> 229
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 229
Asp Val Val Asp 
1               

<210> 230
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 230
Glu Asn Pro Asp 
1               

<210> 231
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 231
Asp Met Ala Asp 
1               

<210> 232
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 232
Asp Leu Ile Asp 
1               

<210> 233
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 233
Asp Gly Ala Asp 
1               

<210> 234
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 234
Asp Val Lys Asp 
1               

<210> 235
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 235
Gly Tyr Asn Asp 
1               

<210> 236
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 236
Glu Leu Pro Asp 
1               

<210> 237
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 237
Asp Ser Thr Asp 
1               

<210> 238
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 238
Asp Arg Gln Asp 
1               

<210> 239
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 239
His Ala Val Asp 
1               

<210> 240
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 240
Gln Glu Arg Leu Asp 
1               5   

<210> 241
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 241
Leu Glu Arg Asp 
1               

<210> 242
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 242
Met Met Pro Asp 
1               

<210> 243
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 243
Glu Glu Pro Asp 
1               

<210> 244
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 244
Val Glu Ser Ile Asp 
1               5   

<210> 245
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 245
Glu Ala Met Asp 
1               

<210> 246
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 246
Glu Asp Ala Asp 
1               

<210> 247
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 247
Glu Glu Glu Asp 
1               

<210> 248
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 248
Ala Val Leu Asp 
1               

<210> 249
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 249
Glu Glu Gly Asp 
1               

<210> 250
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 250
Leu Asp Glu Pro Asp 
1               5   

<210> 251
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> recognition site

<400> 251
Lys Asp Glu Val Asp 
1               5   

<210> 252
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion tag

<400> 252
Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp 
1               5                   10                  15  

<210> 253
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> cp caspase-2

<400> 253
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Asp Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 254
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> cp caspase-2

<400> 254
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Val Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 255
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> cp caspase-2

<400> 255
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys Asn Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Val Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 256
<211> 292
<212> PRT
<213> Artificial Sequence


<220> 
<223> cp caspase-2

<400> 256
Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      
Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          
Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              
Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  
Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  
Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      
Gly Thr Glu Phe His Arg Cys Lys His Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         
Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             
Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 
Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 
Ala Leu Val Leu Ser Asn Val His Phe Thr Val Glu Lys Glu Leu Glu 
                165                 170                 175     
Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         
Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             
Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 
Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 
Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     
Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         
Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             
Asp Gln Gln Asp 
    290         

<210> 257
<211> 248
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 257
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      
Thr Val Ala Gln Ala Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys 
            20                  25                  30          
Glu Ala Glu Leu Gln Ala Gln Thr Ala Glu Gln His His His His His 
        35                  40                  45              
His Gly Ser Gly Val Asp Val Ala Asp Phe Pro Thr Ile Pro Leu Ser 
    50                  55                  60                  
Arg Leu Phe Asp Asn Ala Met Leu Arg Ala His Arg Leu His Gln Leu 
65                  70                  75                  80  
Ala Phe Asp Thr Tyr Gln Glu Phe Glu Glu Ala Tyr Ile Pro Lys Glu 
                85                  90                  95      
Gln Lys Tyr Ser Phe Leu Gln Asn Pro Gln Thr Ser Leu Cys Phe Ser 
            100                 105                 110         
Glu Ser Ile Pro Thr Pro Ser Asn Arg Glu Glu Thr Gln Gln Lys Ser 
        115                 120                 125             
Asn Leu Glu Leu Leu Arg Ile Ser Leu Leu Leu Ile Gln Ser Trp Leu 
    130                 135                 140                 
Glu Pro Val Gln Phe Leu Arg Ser Val Phe Ala Asn Ser Leu Val Tyr 
145                 150                 155                 160 
Gly Ala Ser Asp Ser Asn Val Tyr Asp Leu Leu Lys Asp Leu Glu Glu 
                165                 170                 175     
Gly Ile Gln Thr Leu Met Gly Arg Leu Glu Asp Gly Ser Pro Arg Thr 
            180                 185                 190         
Gly Gln Ile Phe Lys Gln Thr Tyr Ser Lys Phe Asp Thr Asn Ser His 
        195                 200                 205             
Asn Asp Asp Ala Leu Leu Lys Asn Tyr Gly Leu Leu Tyr Cys Phe Arg 
    210                 215                 220                 
Lys Asp Met Asp Lys Val Glu Thr Phe Leu Arg Ile Val Gln Cys Arg 
225                 230                 235                 240 
Ser Val Glu Gly Ser Cys Gly Phe 
                245             

<210> 258
<211> 747
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 258
atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac cgtagcgcag      60

gccctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgca agctcaaacc     120

gctgagcaac accatcacca tcaccatggc agcggcgtgg atgtggcgga ttttccgacc     180

attccgctga gccgtctgtt tgataatgca atgctgcgtg cacatcgtct gcatcagctg     240

gcatttgata cctatcaaga atttgaagaa gcgtatatcc cgaaagagca gaaatatagc     300

ttcctgcaga atccgcagac cagcctgtgt tttagcgaaa gcattccgac accgagcaat     360

cgtgaagaaa cccagcagaa aagcaatctg gaactgctgc gtattagcct gctgctgatt     420

cagagctggc tggaaccggt gcagtttctg cgtagcgttt ttgcaaatag cctggtttat     480

ggtgcaagcg atagcaatgt ttatgatctg ctgaaagatc tggaagaagg tattcagacc     540

ctgatgggtc gtctggaaga tggttcaccg cgtaccggtc agatctttaa acagacctat     600

agcaaattcg ataccaacag ccataatgat gatgccctgc tgaaaaacta tggtctgctg     660

tattgtttcc gcaaagatat ggataaagtg gaaacctttc tgcgcattgt tcagtgtcgt     720

agcgttgaag gtagctgtgg tttctaa                                         747


<210> 259
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 259
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Val Asp Val Ala Asp Ser Val Ser Glu Ile Gln Leu Met His Asn Leu 
        35                  40                  45              
Gly Lys His Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys 
    50                  55                  60                  
Leu Gln Asp Val His Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro 
65                  70                  75                  80  
Arg Asp Ala Gly Ser Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu 
                85                  90                  95      
Val Glu Ser His Glu Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val 
            100                 105                 110         
Asn Val Leu Thr Lys Ala Lys Ser Gln 
        115                 120     

<210> 260
<211> 366
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 260
atgctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgca agctcaaacc      60

gctgagcaac accatcacca tcaccatggc agcggcgtgg atgtggcgga tagcgttagc     120

gaaattcagc tgatgcataa tctgggcaaa catctgaata gcatggaacg tgttgaatgg     180

ctgcgtaaaa aactgcagga tgtgcataat tttgttgcac tgggtgcacc gctggcaccg     240

cgtgatgcag gtagtcagcg tcctcgtaaa aaagaagata acgttctggt tgaaagccac     300

gaaaaaagcc tgggtgaagc agataaagca gatgttaatg ttctgaccaa agccaaaagc     360

cagtaa                                                                366


<210> 261
<211> 215
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 261
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Val Asp Val Ala Asp Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 
        35                  40                  45              
Gln Ser Phe Leu Leu Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly 
    50                  55                  60                  
Asp Gly Ala Ala Leu Gln Glu Lys Leu Val Ser Glu Cys Ala Thr Tyr 
65                  70                  75                  80  
Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 
                85                  90                  95      
Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gln Ala Leu Gln Leu 
            100                 105                 110         
Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu Phe Leu Tyr Gln Gly 
        115                 120                 125             
Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu Leu Gly Pro Thr Leu 
    130                 135                 140                 
Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala Thr Thr Ile Trp Gln 
145                 150                 155                 160 
Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gln Pro Thr Gln Gly 
                165                 170                 175     
Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg Arg Ala Gly Gly Val 
            180                 185                 190         
Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu Val Ser Tyr Arg Val 
        195                 200                 205             
Leu Arg His Leu Ala Gln Pro 
    210                 215 

<210> 262
<211> 648
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 262
atgctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgca agctcaaacc      60

gctgagcaac accatcacca tcaccatggc agcggcgtgg atgtggcgga tgcaacaccg     120

ctgggtcctg caagcagcct gccgcagagc tttctgctga aatgtctgga acaggttcgt     180

aaaattcaag gtgatggcgc agcactgcaa gaaaaactgg ttagcgaatg tgcaacctat     240

aaactgtgtc atccggaaga actggttctg ctgggtcata gcctgggtat tccgtgggca     300

ccgctgagta gctgtccgag ccaggcactg cagctggcag gttgtctgag tcagctgcat     360

agcggtctgt ttctgtatca gggtctgctg caggcactgg aaggtattag tccggaactg     420

ggtccgacac tggataccct gcaactggat gttgcagatt ttgcaaccac catttggcag     480

cagatggaag aattaggtat ggcaccagcg ctgcagccga cacagggtgc aatgcctgca     540

tttgcaagcg catttcagcg tcgtgccggt ggtgttctgg ttgcaagcca tctgcagagt     600

tttctggaag ttagctatcg tgttctgcgt catctggcac agccgtaa                  648


<210> 263
<211> 194
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 263
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Val Asp Val Ala Asp Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys 
        35                  40                  45              
Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln 
    50                  55                  60                  
Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu 
65                  70                  75                  80  
Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr 
                85                  90                  95      
Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu 
            100                 105                 110         
Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val 
        115                 120                 125             
Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu 
    130                 135                 140                 
Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val 
145                 150                 155                 160 
Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro 
                165                 170                 175     
Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile 
            180                 185                 190         
Ala Leu 
        

<210> 264
<211> 585
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 264
atgctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgca agctcaaacc      60

gctgagcaac accatcacca tcaccatggc agcggcgtgg atgtggcgga tgtccgttcc     120

agcagccgta cgccgagcga taaacctgtc gcgcacgtag tggcgaatcc gcaagccgag     180

ggtcagctgc agtggctgaa tcgtcgcgcg aacgcgctgc tggccaatgg tgttgagctg     240

cgtgacaacc aactggttgt tccatccgaa ggcctgtacc tgatttattc tcaagtgctg     300

ttcaaaggtc agggttgccc gagcacgcac gtgttgctga cccataccat tagccgcatc     360

gcagtcagct accagaccaa ggtcaacctg ttgagcgcga tcaagtcccc gtgtcaacgt     420

gaaacgcctg agggcgctga ggccaagccg tggtatgagc cgatctacct gggtggcgtg     480

tttcagctgg agaaaggtga ccgtctgagc gcggaaatca accgcccgga ttatttagat     540

tttgccgagt ctggtcaggt gtacttcggc attattgcac tgtga                     585


<210> 265
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 265
Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      
Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          
Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              
Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  
Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Ser Ala Asn 
65                  70                  75                  80  
Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Ser 
                85                  90                  95      
Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         
Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             
Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 
Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 

<210> 266
<211> 161
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 266
Met His His His His His His Ala Ala Gly Ser Ile Thr Thr Leu Pro 
1               5                   10                  15      
Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe 
            20                  25                  30          
Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg 
        35                  40                  45              
Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro 
    50                  55                  60                  
His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile 
65                  70                  75                  80  
Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg 
                85                  90                  95      
Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg 
            100                 105                 110         
Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser 
        115                 120                 125             
Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys 
    130                 135                 140                 
Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys 
145                 150                 155                 160 
Ser 
    

<210> 267
<211> 191
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 267
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Val Asp Val Ala Asp Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu 
        35                  40                  45              
Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
    50                  55                  60                  
Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
65                  70                  75                  80  
Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile 
                85                  90                  95      
Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
            100                 105                 110         
Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
        115                 120                 125             
Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu 
    130                 135                 140                 
Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
145                 150                 155                 160 
Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
                165                 170                 175     
Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
            180                 185                 190     

<210> 268
<211> 191
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 268
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Val Asp Ser Ala Asp Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu 
        35                  40                  45              
Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
    50                  55                  60                  
Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
65                  70                  75                  80  
Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile 
                85                  90                  95      
Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
            100                 105                 110         
Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
        115                 120                 125             
Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu 
    130                 135                 140                 
Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
145                 150                 155                 160 
Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
                165                 170                 175     
Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
            180                 185                 190     

<210> 269
<211> 191
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 269
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Glu Ala Glu Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Val Asp Val Ala Asp Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu 
        35                  40                  45              
Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp 
    50                  55                  60                  
Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His 
65                  70                  75                  80  
Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile 
                85                  90                  95      
Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly 
            100                 105                 110         
Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu 
        115                 120                 125             
Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu 
    130                 135                 140                 
Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr 
145                 150                 155                 160 
Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly 
                165                 170                 175     
Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
            180                 185                 190     

<210> 270
<211> 188
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 270
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Val Asp Val 
            20                  25                  30          
Ala Asp Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp 
        35                  40                  45              
Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg 
    50                  55                  60                  
Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly 
65                  70                  75                  80  
Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln 
                85                  90                  95      
Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Ser Ala 
            100                 105                 110         
Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys 
        115                 120                 125             
Ser Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn 
    130                 135                 140                 
Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu 
145                 150                 155                 160 
Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln 
                165                 170                 175     
Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
            180                 185             

<210> 271
<211> 195
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 271
Met Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu 
1               5                   10                  15      
Gln Ala Gln Thr Ala Glu Gln His His His His His His Gly Ser Gly 
            20                  25                  30          
Ser Gly Ser Gly Val Asp Val Ala Asp Ala Ala Gly Ser Ile Thr Thr 
        35                  40                  45              
Leu Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly 
    50                  55                  60                  
His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe 
65                  70                  75                  80  
Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser 
                85                  90                  95      
Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val 
            100                 105                 110         
Ser Ile Lys Gly Val Ser Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp 
        115                 120                 125             
Gly Arg Leu Leu Ala Ser Lys Ser Val Thr Asp Glu Cys Phe Phe Phe 
    130                 135                 140                 
Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr 
145                 150                 155                 160 
Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly 
                165                 170                 175     
Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser 
            180                 185                 190         
Ala Lys Ser 
        195 

<210> 272
<211> 588
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 272
atgctggagg atccggaacg caacaaagag cgaaaggaag ctgagttgca agctcaaacc      60

gctgagcaac accatcacca tcaccatggt agcggctctg gcagcggcgt ggatgtggcg     120

gatgccgctg gttcgattac taccctgcct gctttacctg aagatggtgg ttctggtgcg     180

ttcccgccgg gtcacttcaa agacccaaaa cgtttgtact gtaaaaacgg tggctttttt     240

ctgcgcatcc atccggacgg ccgcgtggat ggtgtccgtg aaaagtccga cccgcacatt     300

aagctgcaac tgcaggccga ggagcgtggt gttgttagca tcaaaggcgt gagcgcaaat     360

cgttacctgg cgatgaaaga ggatggccgt ctgctggcga gcaagagcgt taccgacgag     420

tgcttcttct ttgaacgcct ggagagcaat aattacaaca cctaccgtag ccgcaagtat     480

acctcttggt atgtggcgct gaagcgtacg ggccagtata aattgggtag caaaacgggt     540

ccgggccaaa aggcaatcct gttcctgccg atgagcgcga aatcctaa                  588


<210> 273
<211> 192
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 273
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      
Thr Val Ala Gln Ala His His His His His His Gly Ser Gly Val Asp 
            20                  25                  30          
Val Ala Asp Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro Val 
        35                  40                  45              
Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp Leu 
    50                  55                  60                  
Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg Asp 
65                  70                  75                  80  
Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser Gln 
                85                  90                  95      
Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu Thr 
            100                 105                 110         
His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn Leu 
        115                 120                 125             
Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly Ala 
    130                 135                 140                 
Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln 
145                 150                 155                 160 
Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp Tyr 
                165                 170                 175     
Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala Leu 
            180                 185                 190         



<210> 274
<211> 579
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 274
atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac cgtagcgcag      60

gcccaccatc accatcacca tggcagcggc gtggatgtgg cggatgtccg ttccagcagc     120

cgtacgccga gcgataaacc tgtcgcgcac gtagtggcga atccgcaagc cgagggtcag     180

ctgcagtggc tgaatcgtcg cgcgaacgcg ctgctggcca atggtgttga gctgcgtgac     240

aaccaactgg ttgttccatc cgaaggcctg tacctgattt attctcaagt gctgttcaaa     300

ggtcagggtt gcccgagcac gcacgtgttg ctgacccata ccattagccg catcgcagtc     360

agctaccaga ccaaggtcaa cctgttgagc gcgatcaagt ccccgtgtca acgtgaaacg     420

cctgagggcg ctgaggccaa gccgtggtat gagccgatct acctgggtgg cgtgtttcag     480

ctggagaaag gtgaccgtct gagcgcggaa atcaaccgcc cggattattt agattttgcc     540

gagtctggtc aggtgtactt cggcattatt gcactgtga                            579


<210> 275
<211> 251
<212> PRT
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 275
Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Glu 
1               5                   10                  15      
Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu 
            20                  25                  30          
Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Ile Asn Tyr Ile Tyr 
        35                  40                  45              
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu 
    50                  55                  60                  
Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
65                  70                  75                  80  
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp 
                85                  90                  95      
Phe Ala Val Tyr Tyr Cys Leu Gln Trp Ser Ser Asn Pro Leu Thr Phe 
            100                 105                 110         
Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
    130                 135                 140                 
Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 
Ala Ser Gly Phe Thr Phe Ser Ser Tyr Asp Met Ser Trp Val Arg Gln 
                165                 170                 175     
Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         
Ser Tyr Thr Tyr Tyr Leu Asp Ser Ile Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             
Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Leu Asp Tyr 
225                 230                 235                 240 
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     

<210> 276
<211> 756
<212> DNA
<213> Artificial Sequence


<220> 
<223> fusion protein

<400> 276
atgcaccatc accatcacca tggcagcggc gtggatgtgg cggatgaaat tgtgctgacc      60

cagagcccgg cgaccctgag cctgagcccg ggtgaacgtg ccaccctgag ctgtagcgcg     120

agcagcagca ttaactatat ctattggtat cagcagaaac cgggccaggc gccgcgtctg     180

ctgatttatc tgaccagcaa cctggccagc ggtgttccgg cgcgttttag cggcagcggt     240

agcggcaccg attttaccct gaccattagc agcctggaac cggaagattt tgcggtgtat     300

tattgcctgc agtggagcag caatccgctg acctttggcg gtggcaccaa agtggaaatt     360

aaacgtggcg gcggtggcag cggtggtggt ggtagcggcg gtggcggcag cgaagtgcag     420

ctggttgaaa gcggtggcgg cctggtgaaa ccgggtggca gcctgcgtct gagctgtgcg     480

gcgagcggct ttacctttag cagctatgat atgagctggg tgcgtcaggc gccgggcaaa     540

ggcctggaat gggtgagcac catcagcagc ggcggcagct atacctatta tctggatagc     600

atcaaaggcc gttttaccat tagccgtgat aacgcgaaaa acagcctgta tctgcagatg     660

aacagcctgc gtgcggaaga taccgcggtt tattattgcg cgcgtcaggg cctggattat     720

tggggccgtg gcaccctggt taccgtgagc agctaa                               756


<210> 277
<211> 276
<212> PRT
<213> Artificial Sequence


<220> 
<223> consensus sequence

<220> 
<221> SITE
<222> 2..3
<223> X can be any amino acid

<220> 
<221> SITE
<222> 5..5
<223> X can be any amino acid

<220> 
<221> SITE
<222> 11..11
<223> X can be any amino acid

<220> 
<221> SITE
<222> 16..16
<223> X can be any amino acid

<220> 
<221> SITE
<222> 18..18
<223> X can be any amino acid

<220> 
<221> SITE
<222> 21..21
<223> X can be any amino acid

<220> 
<221> SITE
<222> 24..25
<223> X can be any amino acid

<220> 
<221> SITE
<222> 32..32
<223> X can be any amino acid

<220> 
<221> SITE
<222> 34..34
<223> X can be any amino acid

<220> 
<221> SITE
<222> 37..38
<223> X can be any amino acid

<220> 
<221> SITE
<222> 42..43
<223> X can be any amino acid

<220> 
<221> SITE
<222> 46..46
<223> X can be any amino acid

<220> 
<221> SITE
<222> 49..49
<223> X can be any amino acid

<220> 
<221> SITE
<222> 53..53
<223> X can be any amino acid

<220> 
<221> SITE
<222> 58..60
<223> X can be any amino acid

<220> 
<221> SITE
<222> 66..66
<223> X can be any amino acid

<220> 
<221> SITE
<222> 76..76
<223> X can be any amino acid

<220> 
<221> SITE
<222> 83..83
<223> X can be any amino acid

<220> 
<221> SITE
<222> 85..91
<223> X can be any amino acid

<220> 
<221> SITE
<222> 94..94
<223> X can be any amino acid

<220> 
<221> SITE
<222> 99..99
<223> X can be any amino acid

<220> 
<221> SITE
<222> 101..101
<223> X can be any amino acid

<220> 
<221> SITE
<222> 106..106
<223> X can be any amino acid

<220> 
<221> SITE
<222> 113..113
<223> X can be any amino acid

<220> 
<221> SITE
<222> 118..118
<223> X can be any amino acid

<220> 
<221> SITE
<222> 121..121
<223> X can be any amino acid

<220> 
<221> SITE
<222> 124..128
<223> X can be any amino acid

<220> 
<221> SITE
<222> 131..135
<223> X can be any amino acid

<220> 
<221> SITE
<222> 137..137
<223> X can be any amino acid

<220> 
<221> SITE
<222> 139..141
<223> X can be any amino acid

<220> 
<221> SITE
<222> 147..147
<223> X can be any amino acid

<220> 
<221> SITE
<222> 156..156
<223> X can be any amino acid

<220> 
<221> SITE
<222> 183..183
<223> X can be any amino acid

<220> 
<221> SITE
<222> 185..185
<223> X can be any amino acid

<220> 
<221> SITE
<222> 189..189
<223> X can be any amino acid

<220> 
<221> SITE
<222> 199..199
<223> X can be any amino acid

<220> 
<221> SITE
<222> 208..209
<223> X can be any amino acid

<220> 
<221> SITE
<222> 211..211
<223> X can be any amino acid

<220> 
<221> SITE
<222> 213..216
<223> X can be any amino acid

<220> 
<221> SITE
<222> 218..218
<223> X can be any amino acid

<220> 
<221> SITE
<222> 220..220
<223> X can be any amino acid

<220> 
<221> SITE
<222> 224..224
<223> X can be any amino acid

<220> 
<221> SITE
<222> 236..237
<223> X can be any amino acid

<220> 
<221> SITE
<222> 240..241
<223> X can be any amino acid

<220> 
<221> SITE
<222> 246..246
<223> X can be any amino acid

<220> 
<221> SITE
<222> 248..248
<223> X can be any amino acid

<220> 
<221> SITE
<222> 250..250
<223> X can be any amino acid

<220> 
<221> SITE
<222> 257..257
<223> X can be any amino acid

<220> 
<221> SITE
<222> 260..260
<223> X can be any amino acid

<220> 
<221> SITE
<222> 267..267
<223> X can be any amino acid

<220> 
<221> SITE
<222> 269..269
<223> X can be any amino acid

<220> 
<221> SITE
<222> 273..273
<223> X can be any amino acid

<400> 277
Gln Xaa Xaa Arg Xaa Cys Ser Ser Pro Arg Xaa Cys Ala Leu Val Xaa 
1               5                   10                  15      
Ser Xaa Val Thr Xaa Asp Pro Xaa Xaa Ala Asp Pro Leu Asp His Xaa 
            20                  25                  30          
Lys Xaa Gly Glu Xaa Xaa Glu Glu Val Xaa Xaa Lys Val Xaa Thr Glu 
        35                  40                  45              
Xaa Asp Phe Val Xaa Ser Val His Arg Xaa Xaa Xaa Ala Gln Ala Met 
    50                  55                  60                  
Arg Xaa Cys Ile Glu Gln Phe Cys Gln Leu Pro Xaa His Arg Thr Ala 
65                  70                  75                  80  
Asp Gly Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Asp Xaa Ala Val 
                85                  90                  95      
Tyr Ser Xaa Asp Xaa Glu Leu Leu Gln Xaa Asp Trp Val Phe Glu Ala 
            100                 105                 110         
Xaa Asp Asn Ser His Xaa Pro Leu Xaa Gln Asn Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             
Phe Val Xaa Xaa Xaa Xaa Xaa Glu Xaa Met Xaa Xaa Xaa Val Val Gln 
    130                 135                 140                 
Asp Thr Xaa Pro Glu Arg Thr Gly Ser Pro Ser Xaa Glu Gln Arg Asp 
145                 150                 155                 160 
Ala Gly Arg Glu Gly Glu Gly Asp Pro Gly Ser Arg Arg Pro Val Ser 
                165                 170                 175     
Leu Gly Arg Pro Arg Ile Xaa Leu Xaa Gln Arg Ser Xaa Met Ile Cys 
            180                 185                 190         
Gly Phe Ala Ser Leu Lys Xaa Gln Arg Leu Ser Thr Ala Ala Met Xaa 
        195                 200                 205             
Xaa Thr Xaa Arg Xaa Xaa Xaa Xaa Val Xaa Glu Xaa Asn Glu Ala Xaa 
    210                 215                 220                 
Arg Leu Arg Ser Arg Asp Thr His Leu Ala Asp Xaa Xaa Val Gln Xaa 
225                 230                 235                 240 
Xaa Ala Arg Ile Lys Xaa Arg Xaa Gly Xaa Ala Pro Gly Thr Pro His 
                245                 250                 255     
Xaa Arg Cys Xaa Glu Met Ser Glu Phe Thr Xaa Ser Xaa Cys Asn Asp 
            260                 265                 270         
Xaa Phe Leu Phe 
        275     

<210> 278
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 278
Gly Gly Ser Gly Gly 
1               5   

<210> 279
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 279
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly 
1               5                   10  

<210> 280
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 280
Gly Ser Gly Ser Gly Ser Gly 
1               5           

<210> 281
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 281
Gly Gly Gly Gly Ser 
1               5   

<210> 282
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 282
Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      
Ala Ser Ala 
            

<210> 283
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 283
Met Phe Lys Phe Lys Lys Lys Phe Leu Val Gly Leu Thr Ala Ala Phe 
1               5                   10                  15      
Met Ser Ile Ser Met Phe Ser Ala Thr Ala Ser Ala 
            20                  25              

<210> 284
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 284
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      
Gly Val Met Ser Ala Gln Ala Met Ala 
            20                  25  

<210> 285
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 285
Met Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr 
1               5                   10                  15      
Leu Leu Ala Gly 
            20  

<210> 286
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 286
Met Asn Lys Val Lys Cys Tyr Val Leu Phe Thr Ala Leu Leu Ser Ser 
1               5                   10                  15      
Leu Tyr Ala His Gly 
            20      

<210> 287
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 287
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      
Thr Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25      

<210> 288
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 288
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      
Thr Val Ala Gln Ala 
            20      

<210> 289
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 289
Met Lys Val Lys Val Leu Ser Leu Leu Val Pro Ala Leu Leu Val Ala 
1               5                   10                  15      
Gly Ala Ala Asn Ala 
            20      

<210> 290
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 290
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      
Ala Gly Thr Ala Asn Ala 
            20          

<210> 291
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 291
Met Arg Ala Lys Leu Leu Gly Ile Val Leu Thr Thr Pro Ile Ala Ile 
1               5                   10                  15      
Ser Ser Phe Ala 
            20  

<210> 292
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 292
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      
Ala Gln Pro Ala Met Ala 
            20          

<210> 293
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 293
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      
Pro Val Thr Lys Ala 
            20      

<210> 294
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 294
Met Lys Lys Ser Thr Leu Ala Leu Val Val Met Gly Ile Val Ala Ser 
1               5                   10                  15      
Ala Ser Val Gln Ala 
            20      

<210> 295
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Polypeptide

<400> 295
Met Lys Lys Asn Ile Ala Phe Leu Leu Ala Ser Met Phe Val Phe Ser 
1               5                   10                  15      
Ile Ala Thr Asn Ala Tyr Ala 
            20              

<210> 296
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> RECOGNITION SITE

<400> 296
Val Asp Val Ala Asp Phe Ala 
1               5           

<210> 297
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> RECOGNITION SITE

<400> 297
Val Asp Val Ala Asp Gly Ala 
1               5           

<210> 298
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> RECOGNITION SITE

<400> 298
Val Asp Val Ala Asp Gln Ala 
1               5           

<210> 299
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> RECOGNITION SITE

<400> 299
Val Asp Val Ala Asp Val Ala 
1               5           

<210> 300
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> RECOGNITION SITE

<400> 300
Val Asp Val Ala Asp His Ala 
1               5           

