                         SEQUENCE LISTING

<110>  Universitt Innsbruck
       Universitt fr Bodenkultur Wien
       ACIB GmbH
 
<120>  BACTERIAL SELECTION SYSTEM FOR TARGET SPECIFIC PROTEASES

<130>  BK022P

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wt sequence of pyrB

<400>  1
atggctaatc cgctatatca gaaacatatc atttccataa acgaccttag tcgcgatgac       60

cttaatctgg tgctggcgac agcggcgaaa ctgaaagcaa acccgcaacc agagctgttg      120

aagcacaaag tcattgccag ctgtttcttc gaagcctcta cccgtacccg cctctctttc      180

gaaacttcca tgcaccgcct gggtgccagc gtggtgggct tttccgacag cgccaataca      240

tcactgggta aaaagggcga aacgctggcc gataccattt cggttatcag cacttacgtt      300

gatgcgatag tgatgcgtca tccgcaggaa ggtgcggcgc gcctggccac cgagttttcc      360

ggcaatgtac cggtactgaa tgccggtgat ggctccaacc aacatccgac gcaaaccttg      420

ctggacttat tcactattca ggaaacccag gggcgtctgg acaatctcca cgtcgcaatg      480

gttggtgacc tgaaatatgg ccgcaccgtt cactccctga ctcaggcgtt agcgaagttc      540

gacggcaacc gtttttactt catcgcgccg gacgcgctgg caatgccgca atacattctg      600

gatatgcttg atgaaaaagg gatcgcctgg agtctgcaca gctctattga agaagtgatg      660

gcggaagttg acatcctgta catgacccgc gtgcaaaaag agcgtctgga cccgtccgag      720

tacgccaacg tgaaagcgca gtttgttctt cgcgccagcg atctccacaa cgccaaagcc      780

aatatgaaag tgctgcatcc gctgccgcgt gttgatgaga ttgcgacgga tgttgataaa      840

acgccacacg cctggtactt ccagcaggca ggcaacggga ttttcgctcg ccaggcgtta      900

ctggcactgg ttctgaatcg cgatctggta ctgtaa                                936


<210>  2
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  2

Met Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn 
1               5                   10                  15      


Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys 
            20                  25                  30          


Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala 
        35                  40                  45              


Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly 
    50                  55                  60                  


Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg 
65                  70                  75                  80  


Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser 
                85                  90                  95      


Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala 
            100                 105                 110         


Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe 
        115                 120                 125             


Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His 
    130                 135                 140                 


Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser 
145                 150                 155                 160 


Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser 
                165                 170                 175     


Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala 
            180                 185                 190         


Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly 
        195                 200                 205             


Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr 
    210                 215                 220                 


Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val 
225                 230                 235                 240 


Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu 
                245                 250                 255     


Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu 
            260                 265                 270         


Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala 
        275                 280                 285             


Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile 
    290                 295                 300                 


Leu Tyr 
305     


<210>  3
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  3
atgcaccatc atcatcatca tggcagcggc tgggaacatg atatgacccg cgtgcaaaaa       60

gagcgtctgg acccgtccga gtacgccaac gtgaaagcgc agtttgttct tcgcgccagc      120

gatctccaca acgccaaagc caatatgaaa gtgctgcatc cgctgccgcg tgttgatgag      180

attgcgacgg atgttgataa aacgccacac gcctggtact tccagcaggc aggcaacggg      240

attttcgctc gccaggcgtt actggcactg gttctgaatc gcgctaatcc gctatatcag      300

aaacatatca tttccataaa cgaccttagt cgcgatgacc ttaatctggt gctggcgaca      360

gcggcgaaac tgaaagcaaa cccgcaacca gagctgttga agcacaaagt cattgccagc      420

tgtttcttcg aagcctctac ccgtacccgc ctctctttcg aaacttccat gcaccgcctg      480

ggtgccagcg tggtgggctt ttccgacagc gccaatacat cactgggtaa aaagggcgaa      540

acgctggccg ataccatttc ggttatcagc acttacgttg atgcgatagt gatgcgtcat      600

ccgcaggaag gtgcggcgcg cctggccacc gagttttccg gcaatgtacc ggtactgaat      660

gccggtgatg gctccaacca acatccgacg caaaccttgc tggacttatt cactattcag      720

gaaacccagg ggcgtctgga caatctccac gtcgcaatgg ttggtgacct gaaatatggc      780

cgcaccgttc actccctgac tcaggcgtta gcgaagttcg acggcaaccg tttttacttc      840

atcgcgccgg acgcgctggc aatgccgcaa tacattctgg atatgcttga tgaaaaaggg      900

atcgcctgga gtctgcacag ctctattgaa gaagtgatgg cggaagttga catcctgtac      960

taa                                                                    963


<210>  4
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  4

Met His His His His His His Gly Ser Gly Trp Glu His Asp Met Thr 
1               5                   10                  15      


Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys 
            20                  25                  30          


Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn 
        35                  40                  45              


Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp 
    50                  55                  60                  


Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly 
65                  70                  75                  80  


Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn 
                85                  90                  95      


Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp 
            100                 105                 110         


Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro 
        115                 120                 125             


Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu 
    130                 135                 140                 


Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu 
145                 150                 155                 160 


Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly 
                165                 170                 175     


Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr 
            180                 185                 190         


Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu 
        195                 200                 205             


Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly 
    210                 215                 220                 


Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln 
225                 230                 235                 240 


Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp 
                245                 250                 255     


Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys 
            260                 265                 270         


Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met 
        275                 280                 285             


Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser 
    290                 295                 300                 


Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 320 


<210>  5
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  5
atgcaccatc atcatcatca tggcagcggc gtggaaattg atatgacccg cgtgcaaaaa       60

gagcgtctgg acccgtccga gtacgccaac gtgaaagcgc agtttgttct tcgcgccagc      120

gatctccaca acgccaaagc caatatgaaa gtgctgcatc cgctgccgcg tgttgatgag      180

attgcgacgg atgttgataa aacgccacac gcctggtact tccagcaggc aggcaacggg      240

attttcgctc gccaggcgtt actggcactg gttctgaatc gcgctaatcc gctatatcag      300

aaacatatca tttccataaa cgaccttagt cgcgatgacc ttaatctggt gctggcgaca      360

gcggcgaaac tgaaagcaaa cccgcaacca gagctgttga agcacaaagt cattgccagc      420

tgtttcttcg aagcctctac ccgtacccgc ctctctttcg aaacttccat gcaccgcctg      480

ggtgccagcg tggtgggctt ttccgacagc gccaatacat cactgggtaa aaagggcgaa      540

acgctggccg ataccatttc ggttatcagc acttacgttg atgcgatagt gatgcgtcat      600

ccgcaggaag gtgcggcgcg cctggccacc gagttttccg gcaatgtacc ggtactgaat      660

gccggtgatg gctccaacca acatccgacg caaaccttgc tggacttatt cactattcag      720

gaaacccagg ggcgtctgga caatctccac gtcgcaatgg ttggtgacct gaaatatggc      780

cgcaccgttc actccctgac tcaggcgtta gcgaagttcg acggcaaccg tttttacttc      840

atcgcgccgg acgcgctggc aatgccgcaa tacattctgg atatgcttga tgaaaaaggg      900

atcgcctgga gtctgcacag ctctattgaa gaagtgatgg cggaagttga catcctgtac      960

taa                                                                    963


<210>  6
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  6

Met His His His His His His Gly Ser Gly Val Glu Ile Asp Met Thr 
1               5                   10                  15      


Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys 
            20                  25                  30          


Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn 
        35                  40                  45              


Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp 
    50                  55                  60                  


Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly 
65                  70                  75                  80  


Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn 
                85                  90                  95      


Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp 
            100                 105                 110         


Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro 
        115                 120                 125             


Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu 
    130                 135                 140                 


Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu 
145                 150                 155                 160 


Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly 
                165                 170                 175     


Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr 
            180                 185                 190         


Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu 
        195                 200                 205             


Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly 
    210                 215                 220                 


Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln 
225                 230                 235                 240 


Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp 
                245                 250                 255     


Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys 
            260                 265                 270         


Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met 
        275                 280                 285             


Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser 
    290                 295                 300                 


Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 320 


<210>  7
<211>  465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pyrI

<400>  7
atgggcacac acgataataa attgcaggtt gaagctatta aacgcggcac ggtaattgac       60

catatccccg cccagatcgg ttttaagctg ttgagtctgt tcaagctgac cgaaacggat      120

cagcgcatca ccatcggtct gaacttacct tctggcgaga tgggccgcaa agatctgatc      180

aaaatcgaaa ataccttttt gagtgaagac caggtagaac aactggcatt gtatgcgccg      240

caagccacgg ttaaccgtat cgacaactat gaagtggtgg gtaaatcgcg cccaagtctg      300

ccggagcgca tcgacaatgt gctggtctgc ccgaacagca actgtatcag ccatgccgaa      360

ccggtttcat ccagctttgc cgtgcgaaaa cgcgccaatg acatcgcgct caaatgcaaa      420

tactgtgaaa aagagttttc ccataatgtg gtgctggcca attaa                      465


<210>  8
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pyrI

<400>  8

Met Gly Thr His Asp Asn Lys Leu Gln Val Glu Ala Ile Lys Arg Gly 
1               5                   10                  15      


Thr Val Ile Asp His Ile Pro Ala Gln Ile Gly Phe Lys Leu Leu Ser 
            20                  25                  30          


Leu Phe Lys Leu Thr Glu Thr Asp Gln Arg Ile Thr Ile Gly Leu Asn 
        35                  40                  45              


Leu Pro Ser Gly Glu Met Gly Arg Lys Asp Leu Ile Lys Ile Glu Asn 
    50                  55                  60                  


Thr Phe Leu Ser Glu Asp Gln Val Glu Gln Leu Ala Leu Tyr Ala Pro 
65                  70                  75                  80  


Gln Ala Thr Val Asn Arg Ile Asp Asn Tyr Glu Val Val Gly Lys Ser 
                85                  90                  95      


Arg Pro Ser Leu Pro Glu Arg Ile Asp Asn Val Leu Val Cys Pro Asn 
            100                 105                 110         


Ser Asn Cys Ile Ser His Ala Glu Pro Val Ser Ser Ser Phe Ala Val 
        115                 120                 125             


Arg Lys Arg Ala Asn Asp Ile Ala Leu Lys Cys Lys Tyr Cys Glu Lys 
    130                 135                 140                 


Glu Phe Ser His Asn Val Val Leu Ala Asn 
145                 150                 


<210>  9
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pyrI wild type

<400>  9
atgacacacg ataataaatt gcaggttgaa gctattaaac gcggcacggt aattgaccat       60

atccccgccc agatcggttt taagctgttg agtctgttca agctgaccga aacggatcag      120

cgcatcacca tcggtctgaa cttaccttct ggcgagatgg gccgcaaaga tctgatcaaa      180

atcgaaaata cctttttgag tgaagaccag gtagatcaac tggcattgta tgcgccgcaa      240

gccacggtta accgtatcga caactatgaa gtggtgggta aatcgcgccc aagtctgccg      300

gagcgcatcg acaatgtgct ggtctgcccg aacagcaact gtatcagcca tgccgaaccg      360

gtttcatcca gctttgccgt gcgaaaacgc gccaatgaca tcgcgctcaa atgcaaatac      420

tgtgaaaaag agttttccca taatgtggtg ctggccaatt aa                         462


<210>  10
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pyrI wild type

<400>  10

Met Thr His Asp Asn Lys Leu Gln Val Glu Ala Ile Lys Arg Gly Thr 
1               5                   10                  15      


Val Ile Asp His Ile Pro Ala Gln Ile Gly Phe Lys Leu Leu Ser Leu 
            20                  25                  30          


Phe Lys Leu Thr Glu Thr Asp Gln Arg Ile Thr Ile Gly Leu Asn Leu 
        35                  40                  45              


Pro Ser Gly Glu Met Gly Arg Lys Asp Leu Ile Lys Ile Glu Asn Thr 
    50                  55                  60                  


Phe Leu Ser Glu Asp Gln Val Asp Gln Leu Ala Leu Tyr Ala Pro Gln 
65                  70                  75                  80  


Ala Thr Val Asn Arg Ile Asp Asn Tyr Glu Val Val Gly Lys Ser Arg 
                85                  90                  95      


Pro Ser Leu Pro Glu Arg Ile Asp Asn Val Leu Val Cys Pro Asn Ser 
            100                 105                 110         


Asn Cys Ile Ser His Ala Glu Pro Val Ser Ser Ser Phe Ala Val Arg 
        115                 120                 125             


Lys Arg Ala Asn Asp Ile Ala Leu Lys Cys Lys Tyr Cys Glu Lys Glu 
    130                 135                 140                 


Phe Ser His Asn Val Val Leu Ala Asn 
145                 150             


<210>  11
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pyrB wild type

<400>  11

Met Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu 
1               5                   10                  15      


Ser Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys 
            20                  25                  30          


Ala Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys 
        35                  40                  45              


Phe Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met 
    50                  55                  60                  


His Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr 
65                  70                  75                  80  


Ser Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile 
                85                  90                  95      


Ser Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala 
            100                 105                 110         


Ala Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala 
        115                 120                 125             


Gly Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe 
    130                 135                 140                 


Thr Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met 
145                 150                 155                 160 


Val Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala 
                165                 170                 175     


Leu Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala 
            180                 185                 190         


Leu Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile 
        195                 200                 205             


Ala Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp 
    210                 215                 220                 


Ile Leu Tyr Met Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu 
225                 230                 235                 240 


Tyr Ala Asn Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His 
                245                 250                 255     


Asn Ala Lys Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp 
            260                 265                 270         


Glu Ile Ala Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln 
        275                 280                 285             


Gln Ala Gly Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val 
    290                 295                 300                 


Leu Asn Arg Asp Leu Val Leu 
305                 310     


<210>  12
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp caspase-7B

<400>  12

Met Ala Asn Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe 
1               5                   10                  15      


Ala Tyr Ser Thr Val Pro Gly Tyr Asn Ser Trp Arg Ser Pro Gly Arg 
            20                  25                  30          


Gly Ser Trp Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly 
        35                  40                  45              


Lys Asp Leu Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val 
    50                  55                  60                  


Ala Arg His Phe Glu Ser Gln Ser Asp Asp Pro His Cys His Glu Lys 
65                  70                  75                  80  


Lys Gln Ile Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe 
                85                  90                  95      


Ser Gln Gly Ser Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val 
            100                 105                 110         


Glu Asp Ser Ala Asn Glu Asp Ser Val Ala Ala Lys Pro Asp Arg Ser 
        115                 120                 125             


Ser Phe Val Pro Ser Leu Cys Ser Lys Lys Lys Lys Asn Val Thr Met 
    130                 135                 140                 


Arg Ser Ile Lys Thr Ala Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn 
145                 150                 155                 160 


Met Asn Phe Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn 
                165                 170                 175     


Phe Asp Lys Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp 
            180                 185                 190         


Ala Glu Ala Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile 
        195                 200                 205             


Val Tyr Asn Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys 
    210                 215                 220                 


Ala Ser Glu Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu 
225                 230                 235                 240 


Leu Ser His Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr 
                245                 250                 255     


Pro Ile Lys Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr 
            260                 265                 270         


Leu Leu Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr 
        275                 280                 285             


Glu Leu Asp Asp Gly Ile Gln Ala Asp 
    290                 295         


<210>  13
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp caspase-7C

<400>  13

Met Ala Asn Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe 
1               5                   10                  15      


Ala Tyr Ser Thr Val Pro Gly Tyr Ser Ser Trp Arg Ser Pro Gly Arg 
            20                  25                  30          


Gly Ser Trp Tyr Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly 
        35                  40                  45              


Lys Asp Leu Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val 
    50                  55                  60                  


Ala Arg His Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys 
65                  70                  75                  80  


Lys Gln Ile Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe 
                85                  90                  95      


Ser Gln Gly Ser Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val 
            100                 105                 110         


Glu Asp Ser Ala Asn Glu Asp Ser Val Ala Ala Lys Pro Asp Arg Ser 
        115                 120                 125             


Ser Phe Asp Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met 
    130                 135                 140                 


Arg Ser Ile Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn 
145                 150                 155                 160 


Met Asn Phe Glu Gln Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn 
                165                 170                 175     


Phe Asp Lys Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp 
            180                 185                 190         


Ala Glu Ala Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile 
        195                 200                 205             


Val Tyr Asn Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys 
    210                 215                 220                 


Ala Ser Glu Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu 
225                 230                 235                 240 


Leu Ser His Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr 
                245                 250                 255     


Pro Ile Lys Val Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr 
            260                 265                 270         


Leu Leu Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr 
        275                 280                 285             


Glu Leu Asp Val Gly Ile Gln Ala Asp 
    290                 295         


<210>  14
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S9 variant

<400>  14

Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          


Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              


Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  


Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  


Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      


Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         


Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             


Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 


Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 


Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     


Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         


Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             


Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 


Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 


Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     


Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         


Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             


Asp Gln Gln Asp 
    290         


<210>  15
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mS9 Pro variant

<400>  15

Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          


Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              


Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  


Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  


Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      


Gly Thr Glu Phe His Arg Cys Lys Val Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         


Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             


Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 


Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 


Ala Leu Val Leu Ser Asn Val His Phe Thr Asp Glu Lys Glu Leu Glu 
                165                 170                 175     


Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         


Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             


Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 


Gly Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 


Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     


Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         


Met Phe Phe Ile Gln Ala Cys Arg Gly Glu Glu Thr Asp Arg Gly Val 
        275                 280                 285             


Asp Gln Gln Asp 
    290         


<210>  16
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6H-GSG-VDVAD-G-E2

<400>  16

Met Arg Gly Ser His His His His His His Gly Ser Gly Val Asp Val 
1               5                   10                  15      


Ala Asp Gly Ile Arg Met Arg Ala Arg Tyr Pro Ser Val Leu Asp Met 
            20                  25                  30          


Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys Cys 
        35                  40                  45              


Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu Leu 
    50                  55                  60                  


Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys Gly 
65                  70                  75                  80  


Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys Pro 
                85                  90                  95      


Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp Glu 
            100                 105                 110         


Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys Pro 
        115                 120                 125             


Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val Asn 
    130                 135                 140                 


Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu Tyr 
145                 150                 155                 160 


Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr Lys 
                165                 170                 175     


Lys Tyr Gly Glu Lys Arg Pro Val Asp 
            180                 185 


<210>  17
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6H-GSG-VDVAD-G-SOD-FLAG

<400>  17

Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Gly 
1               5                   10                  15      


Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln Gly 
            20                  25                  30          


Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val Trp 
        35                  40                  45              


Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val His 
    50                  55                  60                  


Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His Phe 
65                  70                  75                  80  


Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg His 
                85                  90                  95      


Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala Asp 
            100                 105                 110         


Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys Ile 
        115                 120                 125             


Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly Lys 
    130                 135                 140                 


Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg Leu 
145                 150                 155                 160 


Ala Cys Gly Val Ile Gly Thr Ala Gln Val Asp Asp Tyr Lys Asp Asp 
                165                 170                 175     


Asp Asp Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Trp Ser His 
            180                 185                 190         


Pro Gln Phe Glu Lys 
        195         


<210>  18
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpATCase

<400>  18

Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Pro 
1               5                   10                  15      


Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys 
            20                  25                  30          


Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn 
        35                  40                  45              


Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp 
    50                  55                  60                  


Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly 
65                  70                  75                  80  


Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn 
                85                  90                  95      


Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp 
            100                 105                 110         


Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro 
        115                 120                 125             


Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu 
    130                 135                 140                 


Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu 
145                 150                 155                 160 


Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly 
                165                 170                 175     


Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr 
            180                 185                 190         


Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu 
        195                 200                 205             


Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly 
    210                 215                 220                 


Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln 
225                 230                 235                 240 


Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp 
                245                 250                 255     


Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys 
            260                 265                 270         


Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met 
        275                 280                 285             


Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser 
    290                 295                 300                 


Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 320 


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease recognition site

<400>  19

Val Asp Val Ala Asp 
1               5   


<210>  20
<211>  879
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp caspase-2

<400>  20
atgcaccatc atcaccatca tggcaaaaat catgcaggta gtccgggttg tgaagaaagc       60

gcagcaggta aagaaaaact gccgaaaatg cgtctgccga cccgtagcga tatgatttgt      120

ggttatgcat gtctgaaagg caccgcagca atgcgtaata ccaaacgtgg tagctggtat      180

attgaagcac tggcacaggt ttttagcgaa cgtgcatgtg atatgcatgt tgcagatatg      240

ctggttaaag tgaacgccct gattaaagat cgtgaaggtt atgcaccggg tacagaattt      300

catcgttgta aagaaatgag cgagtattgt agcaccctgt gtcgtcatct gtacctgttt      360

ccgggtcatc ctccgaccgg atccggtccg gtttgtctgc aggttaaacc gtgtacaccg      420

gaattttatc agacccattt tcagctggca tatcgtctgc agagccgtcc gcgtggtctg      480

gcactggttc tgagcaatgt tcattttacc ggtgaaaaag aactggaatt tcgtagcggt      540

ggtgatgttg atcatagtac cctggttacc ctgtttaaac tgctgggtta tgacgttcat      600

gttctgtgtg atcagaccgc acaagaaatg caagagaaac tgcagaattt tgcacagctg      660

cctgcacatc gtgttaccga tagctgtatt gttgcactgc tgagccatgg tgttgaaggt      720

gcaatttatg gtgtggatgg caaactgctg caactgcaag aagtgtttca gctgtttgat      780

aatgcaaatt gtccgagcct gcagaataaa ccgaaaatgt tttttatcca ggcctgccgt      840

ggtgatgaaa ccgatcgtgg tgttgatcag caggattaa                             879


<210>  21
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp caspase-2

<400>  21

Met His His His His His His Gly Lys Asn His Ala Gly Ser Pro Gly 
1               5                   10                  15      


Cys Glu Glu Ser Ala Ala Gly Lys Glu Lys Leu Pro Lys Met Arg Leu 
            20                  25                  30          


Pro Thr Arg Ser Asp Met Ile Cys Gly Tyr Ala Cys Leu Lys Gly Thr 
        35                  40                  45              


Ala Ala Met Arg Asn Thr Lys Arg Gly Ser Trp Tyr Ile Glu Ala Leu 
    50                  55                  60                  


Ala Gln Val Phe Ser Glu Arg Ala Cys Asp Met His Val Ala Asp Met 
65                  70                  75                  80  


Leu Val Lys Val Asn Ala Leu Ile Lys Asp Arg Glu Gly Tyr Ala Pro 
                85                  90                  95      


Gly Thr Glu Phe His Arg Cys Lys Glu Met Ser Glu Tyr Cys Ser Thr 
            100                 105                 110         


Leu Cys Arg His Leu Tyr Leu Phe Pro Gly His Pro Pro Thr Gly Ser 
        115                 120                 125             


Gly Pro Val Cys Leu Gln Val Lys Pro Cys Thr Pro Glu Phe Tyr Gln 
    130                 135                 140                 


Thr His Phe Gln Leu Ala Tyr Arg Leu Gln Ser Arg Pro Arg Gly Leu 
145                 150                 155                 160 


Ala Leu Val Leu Ser Asn Val His Phe Thr Gly Glu Lys Glu Leu Glu 
                165                 170                 175     


Phe Arg Ser Gly Gly Asp Val Asp His Ser Thr Leu Val Thr Leu Phe 
            180                 185                 190         


Lys Leu Leu Gly Tyr Asp Val His Val Leu Cys Asp Gln Thr Ala Gln 
        195                 200                 205             


Glu Met Gln Glu Lys Leu Gln Asn Phe Ala Gln Leu Pro Ala His Arg 
    210                 215                 220                 


Val Thr Asp Ser Cys Ile Val Ala Leu Leu Ser His Gly Val Glu Gly 
225                 230                 235                 240 


Ala Ile Tyr Gly Val Asp Gly Lys Leu Leu Gln Leu Gln Glu Val Phe 
                245                 250                 255     


Gln Leu Phe Asp Asn Ala Asn Cys Pro Ser Leu Gln Asn Lys Pro Lys 
            260                 265                 270         


Met Phe Phe Ile Gln Ala Cys Arg Gly Asp Glu Thr Asp Arg Gly Val 
        275                 280                 285             


Asp Gln Gln Asp 
    290         


<210>  22
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caspase chimera

<400>  22
atgcatcacc atcaccatca catggtcgaa attgcagcgg cctccgtgta tacacttccg       60

gcaggcgcgg actttctgat gtgctatagt gttgccgaag gatattatag tcatcgtgag      120

actgtaaatg ggtcgtggta tatccaggat ttgtgcgaga tgctcggtaa atatggctca      180

tctctggagt tcacggagct cctcacttta gtgaaccgca aagtctcgca gcgaagagtg      240

gatttttgca aagatccatc ggcaatcggc aaaaaacaag ttccttgttt tgcgtccatg      300

ctgacgaaaa aacttcattt cttccccaaa tccaatggat ccctggaatc gaatccacgc      360

tcgctggaag aagagaaata tgatatgagt ggtgcaagat tggcgttgat attatgcgta      420

acgaaggccc gcgagggatc tgaagaagat ctggatgcgc tggagcacat gttccgtcaa      480

ctgagatttg aatccaccat gaaacgcgac ccgacggcag agcagttcca ggaggagctt      540

gaaaagtttc aacaggcgat cgattctcgc gaagaccctg tgtcgtgtgc atttgtagtc      600

ctgatggcgc atggtagaga gggtttcctg aaaggtgagg atggtgagat ggttaagctg      660

gagaatttgt ttgaggctct gaacaacaaa aactgccagg cgctgcgcgc caaacctaaa      720

gtgtatatta ttcaagcgtg ccgcggggag cagcgcgatc cgggagaaac ggtggggggt      780

gatgaaatcg tgatggtgat ataa                                             804


<210>  23
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caspase chimera

<400>  23

Met His His His His His His Met Val Glu Ile Ala Ala Ala Ser Val 
1               5                   10                  15      


Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met Cys Tyr Ser Val Ala 
            20                  25                  30          


Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn Gly Ser Trp Tyr Ile 
        35                  40                  45              


Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly Ser Ser Leu Glu Phe 
    50                  55                  60                  


Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val Ser Gln Arg Arg Val 
65                  70                  75                  80  


Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys Lys Gln Val Pro Cys 
                85                  90                  95      


Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe Phe Pro Lys Ser Asn 
            100                 105                 110         


Gly Ser Leu Glu Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp 
        115                 120                 125             


Met Ser Gly Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg 
    130                 135                 140                 


Glu Gly Ser Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln 
145                 150                 155                 160 


Leu Arg Phe Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe 
                165                 170                 175     


Gln Glu Glu Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp 
            180                 185                 190         


Pro Val Ser Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly 
        195                 200                 205             


Phe Leu Lys Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe 
    210                 215                 220                 


Glu Ala Leu Asn Asn Lys Asn Cys Gln Ala Leu Arg Ala Lys Pro Lys 
225                 230                 235                 240 


Val Tyr Ile Ile Gln Ala Cys Arg Gly Glu Gln Arg Asp Pro Gly Glu 
                245                 250                 255     


Thr Val Gly Gly Asp Glu Ile Val Met Val Ile 
            260                 265         


<210>  24
<211>  804
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  active site mutant

<400>  24
atgcatcacc atcaccatca catgatcgaa attgcagcgg cctccgtgta tacacttccg       60

gcaggcgcgg actttctgat gtgctatagt gttgccgaag gatattatag ccatcgtgag      120

actgtaaatg ggtcgtggca tatccaggat ttgtgcgaga tgctcggtaa atatggctca      180

tctctggagt tcacggagct cctcacttta gtgaaccgca aagtctcgca gcgaagagtg      240

gatttttgca aagatccatc ggcaatcggc aaaaaacaag ttccttgttt tgcgtccatg      300

ctgacgaaaa aacttcattt catccccaaa tccaatggat ccctggaatc gaatccacgc      360

tcgctggaag aagagaaata tgatatgagt ggtgcaagat tggcgttgat attatgcgta      420

acgaaggccc gcgagggatc tgaagaagat ctggatgcgc tggagcacat gttccgtcaa      480

ctgagatttg aatccaccat gaaacgcgac ccgacggcag agcagttccg ggaggagctt      540

gaaaagtttc aacaggcgat cgattctcgc gaagaccctg tgtcgtgtgc atttgtagtc      600

ctgatggcgc atggtagaga gggtttcctg aaaggtgagg atggtgagat ggttaagctg      660

gagaatttgt ttgaggctct gaacaacaaa aactgccagg cgccgcgcgc caaacataaa      720

gtgtatatta ttcaagcggc acgcggggag cagcgcgatc cgggagaaac ggtggggggt      780

gatgaaatcg tgatggtgat ataa                                             804


<210>  25
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  active site mutant

<400>  25

Met His His His His His His Met Ile Glu Ile Ala Ala Ala Ser Val 
1               5                   10                  15      


Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met Cys Tyr Ser Val Ala 
            20                  25                  30          


Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn Gly Ser Trp His Ile 
        35                  40                  45              


Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly Ser Ser Leu Glu Phe 
    50                  55                  60                  


Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val Ser Gln Arg Arg Val 
65                  70                  75                  80  


Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys Lys Gln Val Pro Cys 
                85                  90                  95      


Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe Ile Pro Lys Ser Asn 
            100                 105                 110         


Gly Ser Leu Glu Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp 
        115                 120                 125             


Met Ser Gly Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg 
    130                 135                 140                 


Glu Gly Ser Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln 
145                 150                 155                 160 


Leu Arg Phe Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe 
                165                 170                 175     


Arg Glu Glu Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp 
            180                 185                 190         


Pro Val Ser Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly 
        195                 200                 205             


Phe Leu Lys Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe 
    210                 215                 220                 


Glu Ala Leu Asn Asn Lys Asn Cys Gln Ala Pro Arg Ala Lys His Lys 
225                 230                 235                 240 


Val Tyr Ile Ile Gln Ala Ala Arg Gly Glu Gln Arg Asp Pro Gly Glu 
                245                 250                 255     


Thr Val Gly Gly Asp Glu Ile Val Met Val Ile 
            260                 265         


<210>  26
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp caspase-6

<400>  26
atgcatcacc atcaccatca catggtcgaa attgcagcgg cctccgtgta tacacttccg       60

gcaggcgcgg actttctgat gtgctatagt gttgccgaag gatattatag tcatcgtgag      120

actgtaaatg ggtcgtggta tatccaggat ttgtgcgaga tgctcggtaa atatggctca      180

tctctggagt tcacggagct cctcacttta gtgaaccgca aagtctcgca gcgaagagtg      240

gatttttgca aagatccatc ggcaatcggc aaaaaacaag ttccttgttt tgcgtccatg      300

ctgacgaaaa aacttcattt cttccccaaa tccaatggat ccccgatgtc ttctgcgtct      360

ggtttaaggc gcggtcatcc ggctggaggc gaagaaaaca tgactgaaac cgcagcgttc      420

tacaagcggg agatgtttga tcctgcggaa aaatacaaga tggaccatcg tcgtcgtggc      480

atcgcattga tttttaacca tgagcggttc ttctggcact tgaccctgcc tgaacgccga      540

ggaacttgtg ccgacaggga taatttaacg cgcaggttta gcgacttagg ttttgaggtg      600

aagtgtttca acgacctgaa agccgaagaa ttactgctta aaatacatga agtaagcaca      660

gtttcgcacg cggatgcaga ttgcttcgtt tgcgtttttt tgtctcatgg agagggtaac      720

cacatttatg cttacgacgc gaaaattgaa attcagacgt taacaggatt gttcaaaggc      780

gataaatgtc atagtctcgt tggcaaacca aaaatattta ttatacaggc gtgccggggt      840

aatcagcatg atgttcccgt cattcctttg gatgtagtcg attaa                      885


<210>  27
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp caspase-6

<400>  27

Met His His His His His His Met Val Glu Ile Ala Ala Ala Ser Val 
1               5                   10                  15      


Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met Cys Tyr Ser Val Ala 
            20                  25                  30          


Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn Gly Ser Trp Tyr Ile 
        35                  40                  45              


Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly Ser Ser Leu Glu Phe 
    50                  55                  60                  


Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val Ser Gln Arg Arg Val 
65                  70                  75                  80  


Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys Lys Gln Val Pro Cys 
                85                  90                  95      


Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe Phe Pro Lys Ser Asn 
            100                 105                 110         


Gly Ser Pro Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro Ala 
        115                 120                 125             


Gly Gly Glu Glu Asn Met Thr Glu Thr Ala Ala Phe Tyr Lys Arg Glu 
    130                 135                 140                 


Met Phe Asp Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg Gly 
145                 150                 155                 160 


Ile Ala Leu Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr Leu 
                165                 170                 175     


Pro Glu Arg Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg Arg 
            180                 185                 190         


Phe Ser Asp Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys Ala 
        195                 200                 205             


Glu Glu Leu Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His Ala 
    210                 215                 220                 


Asp Ala Asp Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly Asn 
225                 230                 235                 240 


His Ile Tyr Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr Gly 
                245                 250                 255     


Leu Phe Lys Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys Ile 
            260                 265                 270         


Phe Ile Ile Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro Val Ile 
        275                 280                 285             


Pro Leu Asp Val Val Asp 
    290                 


<210>  28
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp caspase-6

<400>  28
atgcatcacc atcaccatca cagcatggtc gaaattgcag cggcctccgt gtatacactt       60

ccggcaggcg cggactttct gatgtgctat agtgttgccg aaggatatta tagtcatcgt      120

gagactgtaa atgggtcgtg gtatatccag gatttgtgcg agatgctcgg taaatatggc      180

tcatctctgg agttcacgga gctcctcact ttagtgaacc gcaaagtctc gcagcgaaga      240

gtggattttt gcaaagatcc atcggcaatc ggcaaaaaac aagttccttg ttttgcgtcc      300

atgctgacga aaaaacttca tttcttcccc aaatccaatg gatccccgat gtcttctgcg      360

tctggtttaa ggcgcggtca tccggctgga ggcgaagaaa acatgactga aaccgcagcg      420

ttctacaagc gggagatgtt tgatcctgcg gaaaaataca agatggacca tcgtcgtcgt      480

ggcatcgcat tgatttttaa ccatgagcgg ttcttctggc acttgaccct gcctgaacgc      540

cgaggaactt gtgccgacag ggataattta acgcgcaggt ttagcgactt aggttttgag      600

gtgaagtgtt tcaacgacct gaaagccgaa gaattactgc ttaaaataca tgaagtaagc      660

acagtttcgc acgcggatgc agattgcttc gtttgcgttt ttttgtctca tggagagggt      720

aaccacattt atgcttacga cgcgaaaatt gaaattcaga cgttaacagg attgttcaaa      780

ggcgataaat gtcatagtct cgttggcaaa ccaaaaatat ttattataca ggcgtgccgg      840

ggtaatcagc atgatgttcc cgtcattcct ttggatgtag tcgattaa                   888


<210>  29
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp caspase-6

<400>  29

Met His His His His His His Ser Met Val Glu Ile Ala Ala Ala Ser 
1               5                   10                  15      


Val Tyr Thr Leu Pro Ala Gly Ala Asp Phe Leu Met Cys Tyr Ser Val 
            20                  25                  30          


Ala Glu Gly Tyr Tyr Ser His Arg Glu Thr Val Asn Gly Ser Trp Tyr 
        35                  40                  45              


Ile Gln Asp Leu Cys Glu Met Leu Gly Lys Tyr Gly Ser Ser Leu Glu 
    50                  55                  60                  


Phe Thr Glu Leu Leu Thr Leu Val Asn Arg Lys Val Ser Gln Arg Arg 
65                  70                  75                  80  


Val Asp Phe Cys Lys Asp Pro Ser Ala Ile Gly Lys Lys Gln Val Pro 
                85                  90                  95      


Cys Phe Ala Ser Met Leu Thr Lys Lys Leu His Phe Phe Pro Lys Ser 
            100                 105                 110         


Asn Gly Ser Pro Met Ser Ser Ala Ser Gly Leu Arg Arg Gly His Pro 
        115                 120                 125             


Ala Gly Gly Glu Glu Asn Met Thr Glu Thr Ala Ala Phe Tyr Lys Arg 
    130                 135                 140                 


Glu Met Phe Asp Pro Ala Glu Lys Tyr Lys Met Asp His Arg Arg Arg 
145                 150                 155                 160 


Gly Ile Ala Leu Ile Phe Asn His Glu Arg Phe Phe Trp His Leu Thr 
                165                 170                 175     


Leu Pro Glu Arg Arg Gly Thr Cys Ala Asp Arg Asp Asn Leu Thr Arg 
            180                 185                 190         


Arg Phe Ser Asp Leu Gly Phe Glu Val Lys Cys Phe Asn Asp Leu Lys 
        195                 200                 205             


Ala Glu Glu Leu Leu Leu Lys Ile His Glu Val Ser Thr Val Ser His 
    210                 215                 220                 


Ala Asp Ala Asp Cys Phe Val Cys Val Phe Leu Ser His Gly Glu Gly 
225                 230                 235                 240 


Asn His Ile Tyr Ala Tyr Asp Ala Lys Ile Glu Ile Gln Thr Leu Thr 
                245                 250                 255     


Gly Leu Phe Lys Gly Asp Lys Cys His Ser Leu Val Gly Lys Pro Lys 
            260                 265                 270         


Ile Phe Ile Ile Gln Ala Cys Arg Gly Asn Gln His Asp Val Pro Val 
        275                 280                 285             


Ile Pro Leu Asp Val Val Asp 
    290                 295 


<210>  30
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEVD-cp pyrB

<400>  30
atgcaccatc atcatcatca tggcagcggc gatgaagtgg atatgacccg cgtgcaaaaa       60

gagcgtctgg acccgtccga gtacgccaac gtgaaagcgc agtttgttct tcgcgccagc      120

gatctccaca acgccaaagc caatatgaaa gtgctgcatc cgctgccgcg tgttgatgag      180

attgcgacgg atgttgataa aacgccacac gcctggtact tccagcaggc aggcaacggg      240

attttcgctc gccaggcgtt actggcactg gttctgaatc gcgctaatcc gctatatcag      300

aaacatatca tttccataaa cgaccttagt cgcgatgacc ttaatctggt gctggcgaca      360

gcggcgaaac tgaaagcaaa cccgcaacca gagctgttga agcacaaagt cattgccagc      420

tgtttcttcg aagcctctac ccgtacccgc ctctctttcg aaacttccat gcaccgcctg      480

ggtgccagcg tggtgggctt ttccgacagc gccaatacat cactgggtaa aaagggcgaa      540

acgctggccg ataccatttc ggttatcagc acttacgttg atgcgatagt gatgcgtcat      600

ccgcaggaag gtgcggcgcg cctggccacc gagttttccg gcaatgtacc ggtactgaat      660

gccggtgatg gctccaacca acatccgacg caaaccttgc tggacttatt cactattcag      720

gaaacccagg ggcgtctgga caatctccac gtcgcaatgg ttggtgacct gaaatatggc      780

cgcaccgttc actccctgac tcaggcgtta gcgaagttcg acggcaaccg tttttacttc      840

atcgcgccgg acgcgctggc aatgccgcaa tacattctgg atatgcttga tgaaaaaggg      900

atcgcctgga gtctgcacag ctctattgaa gaagtgatgg cggaagttga catcctgtac      960

taa                                                                    963


<210>  31
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEVD-cp pyrB

<400>  31

Met His His His His His His Gly Ser Gly Asp Glu Val Asp Met Thr 
1               5                   10                  15      


Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys 
            20                  25                  30          


Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn 
        35                  40                  45              


Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp 
    50                  55                  60                  


Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly 
65                  70                  75                  80  


Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn 
                85                  90                  95      


Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp 
            100                 105                 110         


Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro 
        115                 120                 125             


Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu 
    130                 135                 140                 


Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu 
145                 150                 155                 160 


Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly 
                165                 170                 175     


Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr 
            180                 185                 190         


Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu 
        195                 200                 205             


Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly 
    210                 215                 220                 


Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln 
225                 230                 235                 240 


Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp 
                245                 250                 255     


Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys 
            260                 265                 270         


Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met 
        275                 280                 285             


Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser 
    290                 295                 300                 


Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 320 


<210>  32
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T7A3 tag

<400>  32

Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu Glu 
1               5                   10                  15      


Ala Glu Thr Ala Glu Gln 
            20          


<210>  33
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7A3 tag

<400>  33
ctggaggatc cggaacgcaa caaagagcga aaggaagctg agttggaagc tgagaccgct       60

gagcaa                                                                  66


<210>  34
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7AC tag

<400>  34
ctggaggatc cggaacgcaa caaagagcga aaggaagctg agttgcaagc tcaaaccgct       60

gagcaa                                                                  66


<210>  35
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T7AC tag

<400>  35

Leu Glu Asp Pro Glu Arg Asn Lys Glu Arg Lys Glu Ala Glu Leu Gln 
1               5                   10                  15      


Ala Gln Thr Ala Glu Gln 
            20          


<210>  36
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp caspase-7A

<400>  36

Met Ala Asn Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe 
1               5                   10                  15      


Ala Tyr Ser Thr Val Pro Gly Asn Tyr Ser Trp Arg Ser Pro Gly Arg 
            20                  25                  30          


Gly Ser Arg Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly 
        35                  40                  45              


Lys Asp Leu Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val 
    50                  55                  60                  


Ala Arg His Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys 
65                  70                  75                  80  


Lys Gln Ile Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe 
                85                  90                  95      


Ser Gln Gly Ser Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val 
            100                 105                 110         


Glu Asp Ser Ala Asn Glu Asp Ser Val Ala Ala Lys Pro Asp Arg Ser 
        115                 120                 125             


Ser Phe Val Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met 
    130                 135                 140                 


Arg Ser Ile Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn 
145                 150                 155                 160 


Met Asn Phe Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Glu Asn 
                165                 170                 175     


Phe Asp Lys Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp 
            180                 185                 190         


Ala Glu Ala Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile 
        195                 200                 205             


Val Tyr Asn Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys 
    210                 215                 220                 


Ala Ser Glu Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu 
225                 230                 235                 240 


Leu Ser His Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr 
                245                 250                 255     


Pro Ile Lys Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr 
            260                 265                 270         


Leu Leu Glu Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr 
        275                 280                 285             


Glu Leu Asp Asp Gly Ile Gln Ala Asp 
    290                 295         


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease recognition site

<400>  37

Trp Glu His Asp 
1               


<210>  38
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  38
atgcaccatc atcatcatca tggcagcggc gtggatgtgg cggatacccg cgtgcaaaaa       60

gagcgtctgg acccgtccga gtacgccaac gtgaaagcgc agtttgttct tcgcgccagc      120

gatctccaca acgccaaagc caatatgaaa gtgctgcatc cgctgccgcg tgttgatgag      180

attgcgacgg atgttgataa aacgccacac gcctggtact tccagcaggc aggcaacggg      240

attttcgctc gccaggcgtt actggcactg gttctgaatc gcgctaatcc gctatatcag      300

aaacatatca tttccataaa cgaccttagt cgcgatgacc ttaatctggt gctggcgaca      360

gcggcgaaac tgaaagcaaa cccgcaacca gagctgttga agcacaaagt cattgccagc      420

tgtttcttcg aagcctctac ccgtacccgc ctctctttcg aaacttccat gcaccgcctg      480

ggtgccagcg tggtgggctt ttccgacagc gccaatacat cactgggtaa aaagggcgaa      540

acgctggccg ataccatttc ggttatcagc acttacgttg atgcgatagt gatgcgtcat      600

ccgcaggaag gtgcggcgcg cctggccacc gagttttccg gcaatgtacc ggtactgaat      660

gccggtgatg gctccaacca acatccgacg caaaccttgc tggacttatt cactattcag      720

gaaacccagg ggcgtctgga caatctccac gtcgcaatgg ttggtgacct gaaatatggc      780

cgcaccgttc actccctgac tcaggcgtta gcgaagttcg acggcaaccg tttttacttc      840

atcgcgccgg acgcgctggc aatgccgcaa tacattctgg atatgcttga tgaaaaaggg      900

atcgcctgga gtctgcacag ctctattgaa gaagtgatgg cggaagttga catcctgtac      960

taa                                                                    963


<210>  39
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  39

Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Thr 
1               5                   10                  15      


Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys 
            20                  25                  30          


Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn 
        35                  40                  45              


Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp 
    50                  55                  60                  


Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly 
65                  70                  75                  80  


Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn 
                85                  90                  95      


Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp 
            100                 105                 110         


Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro 
        115                 120                 125             


Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu 
    130                 135                 140                 


Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu 
145                 150                 155                 160 


Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly 
                165                 170                 175     


Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr 
            180                 185                 190         


Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu 
        195                 200                 205             


Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly 
    210                 215                 220                 


Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln 
225                 230                 235                 240 


Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp 
                245                 250                 255     


Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys 
            260                 265                 270         


Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met 
        275                 280                 285             


Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser 
    290                 295                 300                 


Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 320 


<210>  40
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  40
atgcaccatc atcatcatca tggcagcggc gtggatgtgg cggatatgac ccgcgtgcaa       60

aaagagcgtc tggacccgtc cgagtacgcc aacgtgaaag cgcagtttgt tcttcgcgcc      120

agcgatctcc acaacgccaa agccaatatg aaagtgctgc atccgctgcc gcgtgttgat      180

gagattgcga cggatgttga taaaacgcca cacgcctggt acttccagca ggcaggcaac      240

gggattttcg ctcgccaggc gttactggca ctggttctga atcgcgctaa tccgctatat      300

cagaaacata tcatttccat aaacgacctt agtcgcgatg accttaatct ggtgctggcg      360

acagcggcga aactgaaagc aaacccgcaa ccagagctgt tgaagcacaa agtcattgcc      420

agctgtttct tcgaagcctc tacccgtacc cgcctctctt tcgaaacttc catgcaccgc      480

ctgggtgcca gcgtggtggg cttttccgac agcgccaata catcactggg taaaaagggc      540

gaaacgctgg ccgataccat ttcggttatc agcacttacg ttgatgcgat agtgatgcgt      600

catccgcagg aaggtgcggc gcgcctggcc accgagtttt ccggcaatgt accggtactg      660

aatgccggtg atggctccaa ccaacatccg acgcaaacct tgctggactt attcactatt      720

caggaaaccc aggggcgtct ggacaatctc cacgtcgcaa tggttggtga cctgaaatat      780

ggccgcaccg ttcactccct gactcaggcg ttagcgaagt tcgacggcaa ccgtttttac      840

ttcatcgcgc cggacgcgct ggcaatgccg caatacattc tggatatgct tgatgaaaaa      900

gggatcgcct ggagtctgca cagctctatt gaagaagtga tggcggaagt tgacatcctg      960

tactaa                                                                 966


<210>  41
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  41

Met His His His His His His Gly Ser Gly Val Asp Val Ala Asp Met 
1               5                   10                  15      


Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val 
            20                  25                  30          


Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala 
        35                  40                  45              


Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr 
    50                  55                  60                  


Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn 
65                  70                  75                  80  


Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala 
                85                  90                  95      


Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg 
            100                 105                 110         


Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn 
        115                 120                 125             


Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe 
    130                 135                 140                 


Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg 
145                 150                 155                 160 


Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu 
                165                 170                 175     


Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr 
            180                 185                 190         


Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg 
        195                 200                 205             


Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp 
    210                 215                 220                 


Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile 
225                 230                 235                 240 


Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly 
                245                 250                 255     


Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala 
            260                 265                 270         


Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala 
        275                 280                 285             


Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp 
    290                 295                 300                 


Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu 
305                 310                 315                 320 


Tyr 
    


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease recognition site

<400>  42

Val Glu Ile Asp 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease recognition site

<400>  43

Asp Glu Val Asp 
1               


<210>  44
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Npro-pyrB c227

<400>  44
atggaactca atcatttcga actgctctac aaaactagca agcaaaaacc tgttggcgtt       60

gaagagccgg tctacgatac tgcaggtcgt cctctttttg ggaatccgtc cgaagtgcac      120

ccccagtcaa ccctcaagct tccccatgac cgcggacgcg gtgacattcg tacaacgctg      180

cgcgatctgc ctcgtaaagg cgattgtcgc tctggaaacc acctaggtcc ggtgtcgggc      240

atttacatta aaccaggtcc cgtctattac caagactaca ctggtccggt ttaccatcgt      300

gcacctctgg aattctttga tgaagctcaa ttttgcgaag tgactaaacg tattggccgt      360

gtaaccggtt cggacgggaa actgtaccac atctacgtgt gcgttgatgg ctgtatcctg      420

ctgaaactcg cgaagcgcgg aacccctcgc accctgaaat ggatccgtaa cttcactaac      480

tgtccactgt gggtcactag ttgcatgacc cgcgtgcaaa aagagcgtct ggacccgtcc      540

gagtacgcca acgtgaaagc gcagtttgtt cttcgcgcca gcgatctcca caacgccaaa      600

gccaatatga aagtgctgca tccgctgccg cgtgttgatg agattgcgac ggatgttgat      660

aaaacgccac acgcctggta cttccagcag gcaggcaacg ggattttcgc tcgccaggcg      720

ttactggcac tggttctgaa tcgcgctaat ccgctatatc agaaacatat catttccata      780

aacgacctta gtcgcgatga ccttaatctg gtgctggcga cagcggcgaa actgaaagca      840

aacccgcaac cagagctgtt gaagcacaaa gtcattgcca gctgtttctt cgaagcctct      900

acccgtaccc gcctctcttt cgaaacttcc atgcaccgcc tgggtgccag cgtggtgggc      960

ttttccgaca gcgccaatac atcactgggt aaaaagggcg aaacgctggc cgataccatt     1020

tcggttatca gcacttacgt tgatgcgata gtgatgcgtc atccgcagga aggtgcggcg     1080

cgcctggcca ccgagttttc cggcaatgta ccggtactga atgccggtga tggctccaac     1140

caacatccga cgcaaacctt gctggactta ttcactattc aggaaaccca ggggcgtctg     1200

gacaatctcc acgtcgcaat ggttggtgac ctgaaatatg gccgcaccgt tcactccctg     1260

actcaggcgt tagcgaagtt cgacggcaac cgtttttact tcatcgcgcc ggacgcgctg     1320

gcaatgccgc aatacattct ggatatgctt gatgaaaaag ggatcgcctg gagtctgcac     1380

agctctattg aagaagtgat ggcggaagtt gacatcctgt actaa                     1425


<210>  45
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Npro-pyrB c227

<400>  45

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Ser Lys Gln Lys 
1               5                   10                  15      


Pro Val Gly Val Glu Glu Pro Val Tyr Asp Thr Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asn Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asp Ile Arg Thr Thr Leu Arg Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Ile Lys Pro Gly Pro Val Tyr Tyr Gln Asp Tyr Thr Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Asp Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Val Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Thr Pro Arg Thr Leu Lys Trp Ile Arg Asn Phe Thr Asn 
145                 150                 155                 160 


Cys Pro Leu Trp Val Thr Ser Cys Met Thr Arg Val Gln Lys Glu Arg 
                165                 170                 175     


Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys Ala Gln Phe Val Leu Arg 
            180                 185                 190         


Ala Ser Asp Leu His Asn Ala Lys Ala Asn Met Lys Val Leu His Pro 
        195                 200                 205             


Leu Pro Arg Val Asp Glu Ile Ala Thr Asp Val Asp Lys Thr Pro His 
    210                 215                 220                 


Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly Ile Phe Ala Arg Gln Ala 
225                 230                 235                 240 


Leu Leu Ala Leu Val Leu Asn Arg Ala Asn Pro Leu Tyr Gln Lys His 
                245                 250                 255     


Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp Asp Leu Asn Leu Val Leu 
            260                 265                 270         


Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro Gln Pro Glu Leu Leu Lys 
        275                 280                 285             


His Lys Val Ile Ala Ser Cys Phe Phe Glu Ala Ser Thr Arg Thr Arg 
    290                 295                 300                 


Leu Ser Phe Glu Thr Ser Met His Arg Leu Gly Ala Ser Val Val Gly 
305                 310                 315                 320 


Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly Lys Lys Gly Glu Thr Leu 
                325                 330                 335     


Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr Val Asp Ala Ile Val Met 
            340                 345                 350         


Arg His Pro Gln Glu Gly Ala Ala Arg Leu Ala Thr Glu Phe Ser Gly 
        355                 360                 365             


Asn Val Pro Val Leu Asn Ala Gly Asp Gly Ser Asn Gln His Pro Thr 
    370                 375                 380                 


Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln Glu Thr Gln Gly Arg Leu 
385                 390                 395                 400 


Asp Asn Leu His Val Ala Met Val Gly Asp Leu Lys Tyr Gly Arg Thr 
                405                 410                 415     


Val His Ser Leu Thr Gln Ala Leu Ala Lys Phe Asp Gly Asn Arg Phe 
            420                 425                 430         


Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met Pro Gln Tyr Ile Leu Asp 
        435                 440                 445             


Met Leu Asp Glu Lys Gly Ile Ala Trp Ser Leu His Ser Ser Ile Glu 
    450                 455                 460                 


Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
465                 470                 


<210>  46
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Npro-pyrB c227

<400>  46
atggaactca atcatttcga actgctctac aaaactagca agcaaaaacc tgttggcgtt       60

gaagagccgg tctacgatac tgcaggtcgt cctctttttg ggaatccgtc cgaagtgcac      120

ccccagtcaa ccctcaagct tccccatgac cgcggacgcg gtgacattcg tacaacgctg      180

cgcgatctgc ctcgtaaagg cgattgtcgc tctggaaacc acctaggtcc ggtgtcgggc      240

atttacatta aaccaggtcc cgtctattac caagactaca ctggtccggt ttaccatcgt      300

gcacctctgg aattctttga tgaagctcaa ttttgcgaag tgactaaacg tattggccgt      360

gtaaccggtt cggacgggaa actgtaccac atctacgtgt gcgttgatgg ctgtatcctg      420

ctgaaactcg cgaagcgcgg aacccctcgc accctgaaat ggatccgtaa cttcactaac      480

tgtccactgg cggtcactag ttgcatgacc cgcgtgcaaa aagagcgtct ggacccgtcc      540

gagtacgcca acgtgaaagc gcagtttgtt cttcgcgcca gcgatctcca caacgccaaa      600

gccaatatga aagtgctgca tccgctgccg cgtgttgatg agattgcgac ggatgttgat      660

aaaacgccac acgcctggta cttccagcag gcaggcaacg ggattttcgc tcgccaggcg      720

ttactggcac tggttctgaa tcgcgctaat ccgctatatc agaaacatat catttccata      780

aacgacctta gtcgcgatga ccttaatctg gtgctggcga cagcggcgaa actgaaagca      840

aacccgcaac cagagctgtt gaagcacaaa gtcattgcca gctgtttctt cgaagcctct      900

acccgtaccc gcctctcttt cgaaacttcc atgcaccgcc tgggtgccag cgtggtgggc      960

ttttccgaca gcgccaatac atcactgggt aaaaagggcg aaacgctggc cgataccatt     1020

tcggttatca gcacttacgt tgatgcgata gtgatgcgtc atccgcagga aggtgcggcg     1080

cgcctggcca ccgagttttc cggcaatgta ccggtactga atgccggtga tggctccaac     1140

caacatccga cgcaaacctt gctggactta ttcactattc aggaaaccca ggggcgtctg     1200

gacaatctcc acgtcgcaat ggttggtgac ctgaaatatg gccgcaccgt tcactccctg     1260

actcaggcgt tagcgaagtt cgacggcaac cgtttttact tcatcgcgcc ggacgcgctg     1320

gcaatgccgc aatacattct ggatatgctt gatgaaaaag ggatcgcctg gagtctgcac     1380

agctctattg aagaagtgat ggcggaagtt gacatcctgt actaa                     1425


<210>  47
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Npro-pyrB c227

<400>  47

Met Glu Leu Asn His Phe Glu Leu Leu Tyr Lys Thr Ser Lys Gln Lys 
1               5                   10                  15      


Pro Val Gly Val Glu Glu Pro Val Tyr Asp Thr Ala Gly Arg Pro Leu 
            20                  25                  30          


Phe Gly Asn Pro Ser Glu Val His Pro Gln Ser Thr Leu Lys Leu Pro 
        35                  40                  45              


His Asp Arg Gly Arg Gly Asp Ile Arg Thr Thr Leu Arg Asp Leu Pro 
    50                  55                  60                  


Arg Lys Gly Asp Cys Arg Ser Gly Asn His Leu Gly Pro Val Ser Gly 
65                  70                  75                  80  


Ile Tyr Ile Lys Pro Gly Pro Val Tyr Tyr Gln Asp Tyr Thr Gly Pro 
                85                  90                  95      


Val Tyr His Arg Ala Pro Leu Glu Phe Phe Asp Glu Ala Gln Phe Cys 
            100                 105                 110         


Glu Val Thr Lys Arg Ile Gly Arg Val Thr Gly Ser Asp Gly Lys Leu 
        115                 120                 125             


Tyr His Ile Tyr Val Cys Val Asp Gly Cys Ile Leu Leu Lys Leu Ala 
    130                 135                 140                 


Lys Arg Gly Thr Pro Arg Thr Leu Lys Trp Ile Arg Asn Phe Thr Asn 
145                 150                 155                 160 


Cys Pro Leu Ala Val Thr Ser Cys Met Thr Arg Val Gln Lys Glu Arg 
                165                 170                 175     


Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys Ala Gln Phe Val Leu Arg 
            180                 185                 190         


Ala Ser Asp Leu His Asn Ala Lys Ala Asn Met Lys Val Leu His Pro 
        195                 200                 205             


Leu Pro Arg Val Asp Glu Ile Ala Thr Asp Val Asp Lys Thr Pro His 
    210                 215                 220                 


Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly Ile Phe Ala Arg Gln Ala 
225                 230                 235                 240 


Leu Leu Ala Leu Val Leu Asn Arg Ala Asn Pro Leu Tyr Gln Lys His 
                245                 250                 255     


Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp Asp Leu Asn Leu Val Leu 
            260                 265                 270         


Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro Gln Pro Glu Leu Leu Lys 
        275                 280                 285             


His Lys Val Ile Ala Ser Cys Phe Phe Glu Ala Ser Thr Arg Thr Arg 
    290                 295                 300                 


Leu Ser Phe Glu Thr Ser Met His Arg Leu Gly Ala Ser Val Val Gly 
305                 310                 315                 320 


Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly Lys Lys Gly Glu Thr Leu 
                325                 330                 335     


Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr Val Asp Ala Ile Val Met 
            340                 345                 350         


Arg His Pro Gln Glu Gly Ala Ala Arg Leu Ala Thr Glu Phe Ser Gly 
        355                 360                 365             


Asn Val Pro Val Leu Asn Ala Gly Asp Gly Ser Asn Gln His Pro Thr 
    370                 375                 380                 


Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln Glu Thr Gln Gly Arg Leu 
385                 390                 395                 400 


Asp Asn Leu His Val Ala Met Val Gly Asp Leu Lys Tyr Gly Arg Thr 
                405                 410                 415     


Val His Ser Leu Thr Gln Ala Leu Ala Lys Phe Asp Gly Asn Arg Phe 
            420                 425                 430         


Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met Pro Gln Tyr Ile Leu Asp 
        435                 440                 445             


Met Leu Asp Glu Lys Gly Ile Ala Trp Ser Leu His Ser Ser Ile Glu 
    450                 455                 460                 


Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
465                 470                 


<210>  48
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mpro-cp pyrB c227

<400>  48
atgagcggtt ttcgtaaaat ggcatttccg agcggtaaag ttgaaggttg tatggttcag       60

gttacctgtg gcaccaccac actgaatggt ctgtggctgg atgatgttgt ttattgtccg      120

cgtcatgtta tttgtaccag cgaagatatg ctgaacccga attatgaaga tctgctgatt      180

cgcaaaagca accataattt tctggttcag gcaggtaatg ttcagctgcg tgttattggt      240

catagcatgc agaattgtgt gctgaaactg aaagttgata ccgccaatcc gaaaacgccg      300

aaatataagt ttgttcgtat tcagcctggt cagaccttta gcgttctggc atgttataat      360

ggtagcccga gcggtgttta tcagtgtgca atgcgtccga attttaccat taaaggcagc      420

tttctgaatg gtagctgtgg tagcgttggt ttcaacattg attatgattg cgtgagcttc      480

tgctatatgc atcacatgga actgccgacc ggtgttcatg caggcaccga tctggaaggt      540

aacttttatg gtccgtttgt tgatcgtcag accgcacagg cagcaggtac agataccacc      600

attaccgtta atgttctggc ctggctgtat gcagcagtta ttaatggtga tcgctggttt      660

ctgaatcgtt ttacaacaac cctgaacgat tttaatctgg tggccatgaa atataactat      720

gaaccgctga cacaggatca tgttgatatt ctgggtccgc tgagcgcaca gaccggtatt      780

gcagttctgg atatgtgtgc aagcctgaaa gaactgttac agaatggtat gaatggtcgt      840

acaattctgg gtagcgcact gctggaagat gaattcaccc cgtttgatgt tgtgcgtcag      900

tgtagcggtg ttacctttca gtcgcgcgtg caaaaagagc gtctggaccc gtccgagtac      960

gccaacgtga aagcgcagtt tgttcttcgc gccagcgatc tccacaacgc caaagccaat     1020

atgaaagtgc tgcatccgct gccgcgtgtt gatgagattg cgacggatgt tgataaaacg     1080

ccacacgcct ggtacttcca gcaggcaggc aacgggattt tcgctcgcca ggcgttactg     1140

gcactggttc tgaatcgcgc taatccgcta tatcagaaac atatcatttc cataaacgac     1200

cttagtcgcg atgaccttaa tctggtgctg gcgacagcgg cgaaactgaa agcaaacccg     1260

caaccagagc tgttgaagca caaagtcatt gccagctgtt tcttcgaagc ctctacccgt     1320

acccgcctct ctttcgaaac ttccatgcac cgcctgggtg ccagcgtggt gggcttttcc     1380

gacagcgcca atacatcact gggtaaaaag ggcgaaacgc tggccgatac catttcggtt     1440

atcagcactt acgttgatgc gatagtgatg cgtcatccgc aggaaggtgc ggcgcgcctg     1500

gccaccgagt tttccggcaa tgtaccggta ctgaatgccg gtgatggctc caaccaacat     1560

ccgacgcaaa ccttgctgga cttattcact attcaggaaa cccaggggcg tctggacaat     1620

ctccacgtcg caatggttgg tgacctgaaa tatggccgca ccgttcactc cctgactcag     1680

gcgttagcga agttcgacgg caaccgtttt tacttcatcg cgccggacgc gctggcaatg     1740

ccgcaataca ttctggatat gcttgatgaa aaagggatcg cctggagtct gcacagctct     1800

attgaagaag tgatggcgga agttgacatc ctgtactaa                            1839


<210>  49
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mpro-cp pyrB c227

<400>  49

Met Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly 
1               5                   10                  15      


Cys Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp 
            20                  25                  30          


Leu Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu 
        35                  40                  45              


Asp Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn 
    50                  55                  60                  


His Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly 
65                  70                  75                  80  


His Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn 
                85                  90                  95      


Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr 
            100                 105                 110         


Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln 
        115                 120                 125             


Cys Ala Met Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly 
    130                 135                 140                 


Ser Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe 
145                 150                 155                 160 


Cys Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr 
                165                 170                 175     


Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala 
            180                 185                 190         


Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp 
        195                 200                 205             


Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe 
    210                 215                 220                 


Thr Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr 
225                 230                 235                 240 


Glu Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala 
                245                 250                 255     


Gln Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu 
            260                 265                 270         


Leu Gln Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu 
        275                 280                 285             


Glu Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val 
    290                 295                 300                 


Thr Phe Gln Ser Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr 
305                 310                 315                 320 


Ala Asn Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn 
                325                 330                 335     


Ala Lys Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu 
            340                 345                 350         


Ile Ala Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln 
        355                 360                 365             


Ala Gly Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu 
    370                 375                 380                 


Asn Arg Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp 
385                 390                 395                 400 


Leu Ser Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu 
                405                 410                 415     


Lys Ala Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser 
            420                 425                 430         


Cys Phe Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser 
        435                 440                 445             


Met His Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn 
    450                 455                 460                 


Thr Ser Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val 
465                 470                 475                 480 


Ile Ser Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly 
                485                 490                 495     


Ala Ala Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn 
            500                 505                 510         


Ala Gly Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu 
        515                 520                 525             


Phe Thr Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala 
    530                 535                 540                 


Met Val Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln 
545                 550                 555                 560 


Ala Leu Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp 
                565                 570                 575     


Ala Leu Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly 
            580                 585                 590         


Ile Ala Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val 
        595                 600                 605             


Asp Ile Leu Tyr 
    610         


<210>  50
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  50

Met Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn 
1               5                   10                  15      


Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys 
            20                  25                  30          


Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala 
        35                  40                  45              


Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly 
    50                  55                  60                  


Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg 
65                  70                  75                  80  


Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser 
                85                  90                  95      


Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala 
            100                 105                 110         


Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe 
        115                 120                 125             


Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His 
    130                 135                 140                 


Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser 
145                 150                 155                 160 


Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser 
                165                 170                 175     


Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala 
            180                 185                 190         


Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly 
        195                 200                 205             


Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr 
    210                 215                 220                 


Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val 
225                 230                 235                 240 


Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu 
                245                 250                 255     


Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu 
            260                 265                 270         


Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala 
        275                 280                 285             


Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile 
    290                 295                 300                 


Leu Tyr Arg 
305         


<210>  51
<211>  924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  51
atgacccgcg tgcaaaaaga gcgtctggac ccgtccgagt acgccaacgt gaaagcgcag       60

tttgttcttc gcgccagcga tctccacaac gccaaagcca atatgaaagt gctgcatccg      120

ctgccgcgtg ttgatgagat tgcgacggat gttgataaaa cgccacacgc ctggtacttc      180

cagcaggcag gcaacgggat tttcgctcgc caggcgttac tggcactggt tctgaatcgc      240

gctaatccgc tatatcagaa acatatcatt tccataaacg accttagtcg cgatgacctt      300

aatctggtgc tggcgacagc ggcgaaactg aaagcaaacc cgcaaccaga gctgttgaag      360

cacaaagtca ttgccagctg tttcttcgaa gcctctaccc gtacccgcct ctctttcgaa      420

acttccatgc accgcctggg tgccagcgtg gtgggctttt ccgacagcgc caatacatca      480

ctgggtaaaa agggcgaaac gctggccgat accatttcgg ttatcagcac ttacgttgat      540

gcgatagtga tgcgtcatcc gcaggaaggt gcggcgcgcc tggccaccga gttttccggc      600

aatgtaccgg tactgaatgc cggtgatggc tccaaccaac atccgacgca aaccttgctg      660

gacttattca ctattcagga aacccagggg cgtctggaca atctccacgt cgcaatggtt      720

ggtgacctga aatatggccg caccgttcac tccctgactc aggcgttagc gaagttcgac      780

ggcaaccgtt tttacttcat cgcgccggac gcgctggcaa tgccgcaata cattctggat      840

atgcttgatg aaaaagggat cgcctggagt ctgcacagct ctattgaaga agtgatggcg      900

gaagttgaca tcctgtaccg ttaa                                             924


<210>  52
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  52

Met Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn 
1               5                   10                  15      


Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys 
            20                  25                  30          


Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala 
        35                  40                  45              


Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly 
    50                  55                  60                  


Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg 
65                  70                  75                  80  


Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser 
                85                  90                  95      


Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala 
            100                 105                 110         


Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe 
        115                 120                 125             


Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His 
    130                 135                 140                 


Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser 
145                 150                 155                 160 


Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser 
                165                 170                 175     


Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala 
            180                 185                 190         


Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly 
        195                 200                 205             


Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr 
    210                 215                 220                 


Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val 
225                 230                 235                 240 


Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu 
                245                 250                 255     


Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu 
            260                 265                 270         


Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala 
        275                 280                 285             


Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile 
    290                 295                 300                 


Leu Tyr Arg Ala Arg 
305                 


<210>  53
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  53
atgacccgcg tgcaaaaaga gcgtctggac ccgtccgagt acgccaacgt gaaagcgcag       60

tttgttcttc gcgccagcga tctccacaac gccaaagcca atatgaaagt gctgcatccg      120

ctgccgcgtg ttgatgagat tgcgacggat gttgataaaa cgccacacgc ctggtacttc      180

cagcaggcag gcaacgggat tttcgctcgc caggcgttac tggcactggt tctgaatcgc      240

gctaatccgc tatatcagaa acatatcatt tccataaacg accttagtcg cgatgacctt      300

aatctggtgc tggcgacagc ggcgaaactg aaagcaaacc cgcaaccaga gctgttgaag      360

cacaaagtca ttgccagctg tttcttcgaa gcctctaccc gtacccgcct ctctttcgaa      420

acttccatgc accgcctggg tgccagcgtg gtgggctttt ccgacagcgc caatacatca      480

ctgggtaaaa agggcgaaac gctggccgat accatttcgg ttatcagcac ttacgttgat      540

gcgatagtga tgcgtcatcc gcaggaaggt gcggcgcgcc tggccaccga gttttccggc      600

aatgtaccgg tactgaatgc cggtgatggc tccaaccaac atccgacgca aaccttgctg      660

gacttattca ctattcagga aacccagggg cgtctggaca atctccacgt cgcaatggtt      720

ggtgacctga aatatggccg caccgttcac tccctgactc aggcgttagc gaagttcgac      780

ggcaaccgtt tttacttcat cgcgccggac gcgctggcaa tgccgcaata cattctggat      840

atgcttgatg aaaaagggat cgcctggagt ctgcacagct ctattgaaga agtgatggcg      900

gaagttgaca tcctgtaccg tgcgcgttaa                                       930


<210>  54
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  54

Met Ala Met Thr Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr 
1               5                   10                  15      


Ala Asn Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn 
            20                  25                  30          


Ala Lys Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu 
        35                  40                  45              


Ile Ala Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln 
    50                  55                  60                  


Ala Gly Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu 
65                  70                  75                  80  


Asn Arg Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp 
                85                  90                  95      


Leu Ser Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu 
            100                 105                 110         


Lys Ala Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser 
        115                 120                 125             


Cys Phe Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser 
    130                 135                 140                 


Met His Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn 
145                 150                 155                 160 


Thr Ser Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val 
                165                 170                 175     


Ile Ser Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly 
            180                 185                 190         


Ala Ala Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn 
        195                 200                 205             


Ala Gly Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu 
    210                 215                 220                 


Phe Thr Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala 
225                 230                 235                 240 


Met Val Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln 
                245                 250                 255     


Ala Leu Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp 
            260                 265                 270         


Ala Leu Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly 
        275                 280                 285             


Ile Ala Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val 
    290                 295                 300                 


Asp Ile Leu Tyr 
305             


<210>  55
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp pyrB

<400>  55
atggccatga cccgcgtgca aaaagagcgt ctggacccgt ccgagtacgc caacgtgaaa       60

gcgcagtttg ttcttcgcgc cagcgatctc cacaacgcca aagccaatat gaaagtgctg      120

catccgctgc cgcgtgttga tgagattgcg acggatgttg ataaaacgcc acacgcctgg      180

tacttccagc aggcaggcaa cgggattttc gctcgccagg cgttactggc actggttctg      240

aatcgcgcta atccgctata tcagaaacat atcatttcca taaacgacct tagtcgcgat      300

gaccttaatc tggtgctggc gacagcggcg aaactgaaag caaacccgca accagagctg      360

ttgaagcaca aagtcattgc cagctgtttc ttcgaagcct ctacccgtac ccgcctctct      420

ttcgaaactt ccatgcaccg cctgggtgcc agcgtggtgg gcttttccga cagcgccaat      480

acatcactgg gtaaaaaggg cgaaacgctg gccgatacca tttcggttat cagcacttac      540

gttgatgcga tagtgatgcg tcatccgcag gaaggtgcgg cgcgcctggc caccgagttt      600

tccggcaatg taccggtact gaatgccggt gatggctcca accaacatcc gacgcaaacc      660

ttgctggact tattcactat tcaggaaacc caggggcgtc tggacaatct ccacgtcgca      720

atggttggtg acctgaaata tggccgcacc gttcactccc tgactcaggc gttagcgaag      780

ttcgacggca accgttttta cttcatcgcg ccggacgcgc tggcaatgcc gcaatacatt      840

ctggatatgc ttgatgaaaa agggatcgcc tggagtctgc acagctctat tgaagaagtg      900

atggcggaag ttgacatcct gtactaa                                          927


<210>  56
<211>  960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  56
atgcaccatc atcatcatca tggcagcggc gccgttctgc agagccgcgt gcaaaaagag       60

cgtctggacc cgtccgagta cgccaacgtg aaagcgcagt ttgttcttcg cgccagcgat      120

ctccacaacg ccaaagccaa tatgaaagtg ctgcatccgc tgccgcgtgt tgatgagatt      180

gcgacggatg ttgataaaac gccacacgcc tggtacttcc agcaggcagg caacgggatt      240

ttcgctcgcc aggcgttact ggcactggtt ctgaatcgcg ctaatccgct atatcagaaa      300

catatcattt ccataaacga ccttagtcgc gatgacctta atctggtgct ggcgacagcg      360

gcgaaactga aagcaaaccc gcaaccagag ctgttgaagc acaaagtcat tgccagctgt      420

ttcttcgaag cctctacccg tacccgcctc tctttcgaaa cttccatgca ccgcctgggt      480

gccagcgtgg tgggcttttc cgacagcgcc aatacatcac tgggtaaaaa gggcgaaacg      540

ctggccgata ccatttcggt tatcagcact tacgttgatg cgatagtgat gcgtcatccg      600

caggaaggtg cggcgcgcct ggccaccgag ttttccggca atgtaccggt actgaatgcc      660

ggtgatggct ccaaccaaca tccgacgcaa accttgctgg acttattcac tattcaggaa      720

acccaggggc gtctggacaa tctccacgtc gcaatggttg gtgacctgaa atatggccgc      780

accgttcact ccctgactca ggcgttagcg aagttcgacg gcaaccgttt ttacttcatc      840

gcgccggacg cgctggcaat gccgcaatac attctggata tgcttgatga aaaagggatc      900

gcctggagtc tgcacagctc tattgaagaa gtgatggcgg aagttgacat cctgtactaa      960


<210>  57
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cpATCase pyrB

<400>  57

Met His His His His His His Gly Ser Gly Ala Val Leu Gln Ser Arg 
1               5                   10                  15      


Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn Val Lys Ala 
            20                  25                  30          


Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys Ala Asn Met 
        35                  40                  45              


Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala Thr Asp Val 
    50                  55                  60                  


Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly Asn Gly Ile 
65                  70                  75                  80  


Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg Ala Asn Pro 
                85                  90                  95      


Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser Arg Asp Asp 
            100                 105                 110         


Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala Asn Pro Gln 
        115                 120                 125             


Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe Phe Glu Ala 
    130                 135                 140                 


Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His Arg Leu Gly 
145                 150                 155                 160 


Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser Leu Gly Lys 
                165                 170                 175     


Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser Thr Tyr Val 
            180                 185                 190         


Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala Arg Leu Ala 
        195                 200                 205             


Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly Asp Gly Ser 
    210                 215                 220                 


Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr Ile Gln Glu 
225                 230                 235                 240 


Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val Gly Asp Leu 
                245                 250                 255     


Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu Ala Lys Phe 
            260                 265                 270         


Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu Ala Met Pro 
        275                 280                 285             


Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala Trp Ser Leu 
    290                 295                 300                 


His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile Leu Tyr 
305                 310                 315                 


<210>  58
<211>  1002
<212>  DNA
<213>  SARS-CoV-2

<400>  58
atgagcggtt ttcgtaaaat ggcatttccg agcggtaaag ttgaaggttg tatggttcag       60

gttacctgtg gcaccaccac actgaatggt ctgtggctgg atgatgttgt ttattgtccg      120

cgtcatgtta tttgtaccag cgaagatatg ctgaacccga attatgaaga tctgctgatt      180

cgcaaaagca accataattt tctggttcag gcaggtaatg ttcagctgcg tgttattggt      240

catagcatgc agaattgtgt gctgaaactg aaagttgata ccgccaatcc gaaaacgccg      300

aaatataagt ttgttcgtat tcagcctggt cagaccttta gcgttctggc atgttataat      360

ggtagcccga gcggtgttta tcagtgtgca atgcgtccga attttaccat taaaggcagc      420

tttctgaatg gtagctgtgg tagcgttggt ttcaacattg attatgattg cgtgagcttc      480

tgctatatgc atcacatgga actgccgacc ggtgttcatg caggcaccga tctggaaggt      540

aacttttatg gtccgtttgt tgatcgtcag accgcacagg cagcaggtac agataccacc      600

attaccgtta atgttctggc ctggctgtat gcagcagtta ttaatggtga tcgctggttt      660

ctgaatcgtt ttacaacaac cctgaacgat tttaatctgg tggccatgaa atataactat      720

gaaccgctga cacaggatca tgttgatatt ctgggtccgc tgagcgcaca gaccggtatt      780

gcagttctgg atatgtgtgc aagcctgaaa gaactgttac agaatggtat gaatggtcgt      840

acaattctgg gtagcgcact gctggaagat gaattcaccc cgtttgatgt tgtgcgtcag      900

tgtagcggtg ttacctttca gtaataactc gagtctggta aagaaaccgc tgctgcgaaa      960

tttgaacgcc agcacatgga ctcgtctact agcgcagctt aa                        1002


<210>  59
<211>  307
<212>  PRT
<213>  SARS-CoV-2

<400>  59

Met Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly 
1               5                   10                  15      


Cys Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp 
            20                  25                  30          


Leu Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu 
        35                  40                  45              


Asp Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn 
    50                  55                  60                  


His Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly 
65                  70                  75                  80  


His Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn 
                85                  90                  95      


Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr 
            100                 105                 110         


Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln 
        115                 120                 125             


Cys Ala Met Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly 
    130                 135                 140                 


Ser Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe 
145                 150                 155                 160 


Cys Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr 
                165                 170                 175     


Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala 
            180                 185                 190         


Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp 
        195                 200                 205             


Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe 
    210                 215                 220                 


Thr Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr 
225                 230                 235                 240 


Glu Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala 
                245                 250                 255     


Gln Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu 
            260                 265                 270         


Leu Gln Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu 
        275                 280                 285             


Glu Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val 
    290                 295                 300                 


Thr Phe Gln 
305         


<210>  60
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cp pyrB c227

<400>  60
atgagccgcg tgcaaaaaga gcgtctggac ccgtccgagt acgccaacgt gaaagcgcag       60

tttgttcttc gcgccagcga tctccacaac gccaaagcca atatgaaagt gctgcatccg      120

ctgccgcgtg ttgatgagat tgcgacggat gttgataaaa cgccacacgc ctggtacttc      180

cagcaggcag gcaacgggat tttcgctcgc caggcgttac tggcactggt tctgaatcgc      240

gctaatccgc tatatcagaa acatatcatt tccataaacg accttagtcg cgatgacctt      300

aatctggtgc tggcgacagc ggcgaaactg aaagcaaacc cgcaaccaga gctgttgaag      360

cacaaagtca ttgccagctg tttcttcgaa gcctctaccc gtacccgcct ctctttcgaa      420

acttccatgc accgcctggg tgccagcgtg gtgggctttt ccgacagcgc caatacatca      480

ctgggtaaaa agggcgaaac gctggccgat accatttcgg ttatcagcac ttacgttgat      540

gcgatagtga tgcgtcatcc gcaggaaggt gcggcgcgcc tggccaccga gttttccggc      600

aatgtaccgg tactgaatgc cggtgatggc tccaaccaac atccgacgca aaccttgctg      660

gacttattca ctattcagga aacccagggg cgtctggaca atctccacgt cgcaatggtt      720

ggtgacctga aatatggccg caccgttcac tccctgactc aggcgttagc gaagttcgac      780

ggcaaccgtt tttacttcat cgcgccggac gcgctggcaa tgccgcaata cattctggat      840

atgcttgatg aaaaagggat cgcctggagt ctgcacagct ctattgaaga agtgatggcg      900

gaagttgaca tcctgtacta a                                                921


<210>  61
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cp pyrB c227

<400>  61

Met Ser Arg Val Gln Lys Glu Arg Leu Asp Pro Ser Glu Tyr Ala Asn 
1               5                   10                  15      


Val Lys Ala Gln Phe Val Leu Arg Ala Ser Asp Leu His Asn Ala Lys 
            20                  25                  30          


Ala Asn Met Lys Val Leu His Pro Leu Pro Arg Val Asp Glu Ile Ala 
        35                  40                  45              


Thr Asp Val Asp Lys Thr Pro His Ala Trp Tyr Phe Gln Gln Ala Gly 
    50                  55                  60                  


Asn Gly Ile Phe Ala Arg Gln Ala Leu Leu Ala Leu Val Leu Asn Arg 
65                  70                  75                  80  


Ala Asn Pro Leu Tyr Gln Lys His Ile Ile Ser Ile Asn Asp Leu Ser 
                85                  90                  95      


Arg Asp Asp Leu Asn Leu Val Leu Ala Thr Ala Ala Lys Leu Lys Ala 
            100                 105                 110         


Asn Pro Gln Pro Glu Leu Leu Lys His Lys Val Ile Ala Ser Cys Phe 
        115                 120                 125             


Phe Glu Ala Ser Thr Arg Thr Arg Leu Ser Phe Glu Thr Ser Met His 
    130                 135                 140                 


Arg Leu Gly Ala Ser Val Val Gly Phe Ser Asp Ser Ala Asn Thr Ser 
145                 150                 155                 160 


Leu Gly Lys Lys Gly Glu Thr Leu Ala Asp Thr Ile Ser Val Ile Ser 
                165                 170                 175     


Thr Tyr Val Asp Ala Ile Val Met Arg His Pro Gln Glu Gly Ala Ala 
            180                 185                 190         


Arg Leu Ala Thr Glu Phe Ser Gly Asn Val Pro Val Leu Asn Ala Gly 
        195                 200                 205             


Asp Gly Ser Asn Gln His Pro Thr Gln Thr Leu Leu Asp Leu Phe Thr 
    210                 215                 220                 


Ile Gln Glu Thr Gln Gly Arg Leu Asp Asn Leu His Val Ala Met Val 
225                 230                 235                 240 


Gly Asp Leu Lys Tyr Gly Arg Thr Val His Ser Leu Thr Gln Ala Leu 
                245                 250                 255     


Ala Lys Phe Asp Gly Asn Arg Phe Tyr Phe Ile Ala Pro Asp Ala Leu 
            260                 265                 270         


Ala Met Pro Gln Tyr Ile Leu Asp Met Leu Asp Glu Lys Gly Ile Ala 
        275                 280                 285             


Trp Ser Leu His Ser Ser Ile Glu Glu Val Met Ala Glu Val Asp Ile 
    290                 295                 300                 


Leu Tyr 
305     


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  62

Gly Gly Gly Gly Ser 
1               5   


