                         SEQUENCE LISTING

<110>  CureVac AG
 
<120>  RNA combinations and compositions with decreased 
       immunostimulatory properties

<130>  CU01P300WO1

<160>  212   

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  histone stem-loop sequence

<400>  1
caaaggctct tttcagagcc acca                                              24


<210>  2
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  histone stem-loop sequence mRNA

<400>  2
caaaggcucu uuucagagcc acca                                              24


<210>  3
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak

<400>  3
gccgccacca tgg                                                          13


<210>  4
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Kozak mRNA

<400>  4
gccgccacca ugg                                                          13


<210>  5
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 5'-end

<400>  5
gggaga                                                                   6


<210>  6
<211>  6
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 5'-end

<400>  6
aggaga                                                                   6


<210>  7
<211>  128
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A64-N5-C30-histoneSL-N5

<400>  7
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca      120

ccagaauu                                                               128


<210>  8
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end histoneSL-A100

<400>  8
caaaggcucu uuucagagcc accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaa                                                                   124


<210>  9
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A100

<400>  9
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                            100


<210>  10
<211>  134
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A64-N5-C30-histoneSL-N5

<400>  10
auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca      120

gagccaccag aauu                                                        134


<210>  11
<211>  134
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A64-N5-C30-histoneSL-N5

<400>  11
agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca      120

gagccaccag aauu                                                        134


<210>  12
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-histoneSL-A64-N5

<400>  12
auuaaucaaa ggcucuuuuc agagccacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaagaauu                              99


<210>  13
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-histoneSL-A64-N5

<400>  13
agaucucaaa ggcucuuuuc agagccacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaagaauu                              99


<210>  14
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N12-A64-N5-histoneSL-N5

<400>  14
auuaauagau cuaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaugca ucaaaggcuc uuuucagagc caccagaauu                 110


<210>  15
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N12-A64-N5-histoneSL-N5

<400>  15
auuaauagau cuaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaugca ucaaaggcuc uuuucagagc caccagaauu                 110


<210>  16
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-histoneSL-A100

<400>  16
auuaaucaaa ggcucuuuuc agagccacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa                                                             130


<210>  17
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-histoneSL-A100

<400>  17
agaucucaaa ggcucuuuuc agagccacca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa                                                             130


<210>  18
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A100

<400>  18
auuaauaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                     106


<210>  19
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A100

<400>  19
agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                     106


<210>  20
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A75-histoneSL

<400>  20
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaacaaag gcucuuuuca gagccacca                              99


<210>  21
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end U3-A75-histoneSL

<400>  21
uuuaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaca aaggcucuuu ucagagccac ca                         102


<210>  22
<211>  178
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A154-histoneSL

<400>  22
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaacaaagg cucuuuucag agccacca        178


<210>  23
<211>  181
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end U3-A154-histoneSL

<400>  23
uuuaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaacaa aggcucuuuu cagagccacc      180

a                                                                      181


<210>  24
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N2-A75-histoneSL

<400>  24
agaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaacaa aggcucuuuu cagagccacc a                          101


<210>  25
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end histoneSL-A75

<400>  25
caaaggcucu uuucagagcc accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                              99


<210>  26
<211>  170
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end histoneSL-A146

<400>  26
caaaggcucu uuucagagcc accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 170


<210>  27
<211>  136
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N8-A64-N5-C30-histoneSL-N5

<400>  27
agauuaauaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      120

cagagccacc agaauu                                                      136


<210>  28
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N8-A64-N5-C30-histoneSL

<400>  28
agauuaauaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaugcauccc cccccccccc cccccccccc ccccccccaa aggcucuuuu      120

cagagccacc a                                                           131


<210>  29
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N8-A64-N5-C4-histoneSL

<400>  29
agauuaauaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaugcauccc ccaaaggcuc uuuucagagc cacca                      105


<210>  30
<211>  115
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N8-A64-N5-C14-histoneSL

<400>  30
agauuaauaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaugcauccc cccccccccc ccaaaggcuc uuuucagagc cacca           115


<210>  31
<211>  129
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A64-N5-C30-histoneSL

<400>  31
agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa ugcauccccc cccccccccc cccccccccc ccccccaaag gcucuuuuca      120

gagccacca                                                              129


<210>  32
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A64-N5-C4-histoneSL

<400>  32
agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa ugcauccccc aaaggcucuu uucagagcca cca                        103


<210>  33
<211>  113
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A64-N5-C14-histoneSL

<400>  33
agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa ugcauccccc cccccccccc aaaggcucuu uucagagcca cca             113


<210>  34
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end N6-A64-histoneSL-N5

<400>  34
agaucuaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa caaaggcucu uuucagagcc accagaauu                              99


<210>  35
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A64-N5-C30-histoneSL

<400>  35
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaugcauc cccccccccc cccccccccc cccccccccc aaaggcucuu uucagagcca      120

cca                                                                    123


<210>  36
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A64-N5-C4-histoneSL

<400>  36
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaugcauc ccccaaaggc ucuuuucaga gccacca                                97


<210>  37
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A64-N5-C14-histoneSL

<400>  37
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaugcauc cccccccccc ccccaaaggc ucuuuucaga gccacca                    107


<210>  38
<211>  93
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mRNA 3'-end A64-histoneSL-N5

<400>  38
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaacaaagg cucuuuucag agccaccaga auu                                    93


<210>  39
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  carrier peptide 1

<400>  39

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  carrier peptide 2

<400>  40

Cys Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10              


<210>  41
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  carrier peptide 3

<400>  41

Trp Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Cys 
1               5                   10                  


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  carrier peptide 4

<400>  42

Cys His His His His His His Arg Arg Arg Arg His His His His His 
1               5                   10                  15      


His Cys 
        


<210>  43
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  carrier peptide 5

<400>  43

Cys Gly His His His His His Arg Arg Arg Arg His His His His His 
1               5                   10                  15      


Gly Cys 
        


<210>  44
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HSD17B4 5'-UTR

<400>  44
gtcccgcagt cggcgtccag cggctctgct tgttcgtgtg tgtgtcgttg caggccttat       60

tc                                                                      62


<210>  45
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  HSD17B4 5'-UTR

<400>  45
gucccgcagu cggcguccag cggcucugcu uguucgugug ugugucguug caggccuuau       60

uc                                                                      62


<210>  46
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASAH1 5'-UTR

<400>  46
gcctctgctg gagtccgggg agtggcgttg gctgctagag cg                          42


<210>  47
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ASAH1 5'-UTR

<400>  47
gccucugcug gaguccgggg aguggcguug gcugcuagag cg                          42


<210>  48
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATP5A1 5'-UTR

<400>  48
gcggctcggc cattttgtcc cagtcagtcc ggaggctgcg gctgcagaag taccgcctgc       60

ggagtaactg caaag                                                        75


<210>  49
<211>  75
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ATP5A1 5'-UTR

<400>  49
gcggcucggc cauuuugucc cagucagucc ggaggcugcg gcugcagaag uaccgccugc       60

ggaguaacug caaag                                                        75


<210>  50
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mp68_(2010107E04Rik) 5'-UTR

<400>  50
ctttcccatt ctgtagcaga atttggtgtt gcctgtggtc ttggtcccgc ggag             54


<210>  51
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mp68_(2010107E04Rik) 5'-UTR

<400>  51
cuuucccauu cuguagcaga auuugguguu gccugugguc uuggucccgc ggag             54


<210>  52
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ndufa4 5'-UTR

<400>  52
gtccgctcag ccaggttgca gaagcggctt agcgtgtgtc ctaatcttct ctctgcgtgt       60

aggtaggcct gtgccgcaaa c                                                 81


<210>  53
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ndufa4 5'-UTR

<400>  53
guccgcucag ccagguugca gaagcggcuu agcguguguc cuaaucuucu cucugcgugu       60

agguaggccu gugccgcaaa c                                                 81


<210>  54
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nosip 5'-UTR

<400>  54
ctcctgtcgg gcggaagtag gaggagtaga gtttaaaaac agtactcttt ttccggttcg       60

ggacgtagtt gaagcaacga caagccggat aaccgctctt gagacagg                   108


<210>  55
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Nosip 5'-UTR

<400>  55
cuccugucgg gcggaaguag gaggaguaga guuuaaaaac aguacucuuu uuccgguucg       60

ggacguaguu gaagcaacga caagccggau aaccgcucuu gagacagg                   108


<210>  56
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rpl31 5'-UTR

<400>  56
cccgtgaccc ggaagttgta cggctacgcg actttccctc ccacaaaccc tcgcgccctt       60

cctttcctac ttgggcccgg caga                                              84


<210>  57
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Rpl31 5'-UTR

<400>  57
cccgugaccc ggaaguugua cggcuacgcg acuuucccuc ccacaaaccc ucgcgcccuu       60

ccuuuccuac uugggcccgg caga                                              84


<210>  58
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Slc7a3 5'-UTR

<400>  58
gggcgcttgg cttgcaagga ccctgagctg cggcattgaa gcacacccaa cccaactcga       60

ctgaagtcag cctcactgaa ccggatctga gaatcttctc tctctgggct tgccagggct      120

ctccgaacct agctagcatc ctcttcaatt ccaactaga                             159


<210>  59
<211>  159
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Slc7a3 5'-UTR

<400>  59
gggcgcuugg cuugcaagga cccugagcug cggcauugaa gcacacccaa cccaacucga       60

cugaagucag ccucacugaa ccggaucuga gaaucuucuc ucucugggcu ugccagggcu      120

cuccgaaccu agcuagcauc cucuucaauu ccaacuaga                             159


<210>  60
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TUBB4B 5'-UTR

<400>  60
atataagcgt tggcggagcg tcggttgtag cactctgcgc gcccgctctt ctgctgctgt       60

ttgtctactt cctcctgctt ccccgccgcc gccgccgcca tc                         102


<210>  61
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TUBB4B 5'-UTR

<400>  61
auauaagcgu uggcggagcg ucgguuguag cacucugcgc gcccgcucuu cugcugcugu       60

uugucuacuu ccuccugcuu ccccgccgcc gccgccgcca uc                         102


<210>  62
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ubqln2 5'-UTR

<400>  62
cggagacggc ctgcaggacc tgctctctca gccctcagcc gaggcctacg ccgagccgag       60

tgcgcagccg acgaccggga ggagccgcag ccttcaactc tgaggtactg tgatccgcgc      120

tgcccgccgg gccgccccag tccgctgctg cggcacctcc ttccctcgcg ccctcttcgc      180

tcgccagcgc cttccctgtg agcctgcgtc accgcggccg cc                         222


<210>  63
<211>  222
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ubqln2 5'-UTR

<400>  63
cggagacggc cugcaggacc ugcucucuca gcccucagcc gaggccuacg ccgagccgag       60

ugcgcagccg acgaccggga ggagccgcag ccuucaacuc ugagguacug ugauccgcgc      120

ugcccgccgg gccgccccag uccgcugcug cggcaccucc uucccucgcg cccucuucgc      180

ucgccagcgc cuucccugug agccugcguc accgcggccg cc                         222


<210>  64
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPL32 (32L4, 32L3) 5'-UTR

<400>  64
ggcgctgcct acggaggtgg cagccatctc cttctcggca tc                          42


<210>  65
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RPL32 (32L4, 32L3) 5'-UTR

<400>  65
ggcgcugccu acggaggugg cagccaucuc cuucucggca uc                          42


<210>  66
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PSMB3 3'-UTR

<400>  66
ccctgttccc agagcccact tttttttctt tttttgaaat aaaatagcct gtctttc          57


<210>  67
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PSMB3 3'-UTR

<400>  67
cccuguuccc agagcccacu uuuuuuucuu uuuuugaaau aaaauagccu gucuuuc          57


<210>  68
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CASP1 3'-UTR

<400>  68
aataaggaaa ctgtatgaat gtctgtgggc aggaagtgaa gagatccttc tgtaaaggtt       60

tttggaatta tgtctgctga ataataaact tttttgaaat aataaatctg gtagaaaaat      120

g                                                                      121


<210>  69
<211>  121
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CASP1 3'-UTR

<400>  69
aauaaggaaa cuguaugaau gucugugggc aggaagugaa gagauccuuc uguaaagguu       60

uuuggaauua ugucugcuga auaauaaacu uuuuugaaau aauaaaucug guagaaaaau      120

g                                                                      121


<210>  70
<211>  137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COX6B1 3'-UTR

<400>  70
actggctgca tctccctttc ctctgtcctc catccttctc ccaggatggt gaagggggac       60

ctggtaccca gtgatcccca ccccaggatc ctaaatcatg acttacctgc taataaaaac      120

tcattggaaa agtgaga                                                     137


<210>  71
<211>  137
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  COX6B1 3'-UTR

<400>  71
acuggcugca ucucccuuuc cucuguccuc cauccuucuc ccaggauggu gaagggggac       60

cugguaccca gugaucccca ccccaggauc cuaaaucaug acuuaccugc uaauaaaaac      120

ucauuggaaa agugaga                                                     137


<210>  72
<211>  353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gnas 3'-UTR

<400>  72
gaagggaaca cccaaattta attcagcctt aagcacaatt aattaagagt gaaacgtaat       60

tgtacaagca gttggtcacc caccataggg catgatcaac accgcaacct ttcctttttc      120

ccccagtgat tctgaaaaac ccctcttccc ttcagcttgc ttagatgttc caaatttagt      180

aagcttaagg cggcctacag aagaaaaaga aaaaaaaggc cacaaaagtt ccctctcact      240

ttcagtaaat aaaataaaag cagcaacaga aataaagaaa taaatgaaat tcaaaatgaa      300

ataaatattg tgttgtgcag cattaaaaaa tcaataaaaa ttaaaaatga gca             353


<210>  73
<211>  353
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Gnas 3'-UTR

<400>  73
gaagggaaca cccaaauuua auucagccuu aagcacaauu aauuaagagu gaaacguaau       60

uguacaagca guuggucacc caccauaggg caugaucaac accgcaaccu uuccuuuuuc      120

ccccagugau ucugaaaaac cccucuuccc uucagcuugc uuagauguuc caaauuuagu      180

aagcuuaagg cggccuacag aagaaaaaga aaaaaaaggc cacaaaaguu cccucucacu      240

uucaguaaau aaaauaaaag cagcaacaga aauaaagaaa uaaaugaaau ucaaaaugaa      300

auaaauauug uguugugcag cauuaaaaaa ucaauaaaaa uuaaaaauga gca             353


<210>  74
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ndufa1 3'-UTR

<400>  74
ggaagcattt tcctggctga ttaaaagaaa ttactcagct atggtcatct gttcctgtta       60

gaaggctatg cagcatatta tatactatgc gcatgttatg aaatgcataa taaaaaattt      120

taaaaaatct aaa                                                         133


<210>  75
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ndufa1 3'-UTR

<400>  75
ggaagcauuu uccuggcuga uuaaaagaaa uuacucagcu auggucaucu guuccuguua       60

gaaggcuaug cagcauauua uauacuaugc gcauguuaug aaaugcauaa uaaaaaauuu      120

uaaaaaaucu aaa                                                         133


<210>  76
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPS9 3'-UTR

<400>  76
gtccacctgt ccctcctggg ctgctggatt gtctcgtttt cctgccaaat aaacaggatc       60

agcgctttac                                                              70


<210>  77
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RPS9 3'-UTR

<400>  77
guccaccugu cccuccuggg cugcuggauu gucucguuuu ccugccaaau aaacaggauc       60

agcgcuuuac                                                              70


<210>  78
<211>  187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALB7 3'-UTR

<400>  78
gcatcacatt taaaagcatc tcagcctacc atgagaataa gagaaagaaa atgaagatca       60

atagcttatt catctctttt tctttttcgt tggtgtaaag ccaacaccct gtctaaaaaa      120

cataaatttc tttaatcatt ttgcctcttt tctctgtgct tcaattaata aaaaatggaa      180

agaacct                                                                187


<210>  79
<211>  187
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ALB7 3'-UTR

<400>  79
gcaucacauu uaaaagcauc ucagccuacc augagaauaa gagaaagaaa augaagauca       60

auagcuuauu caucucuuuu ucuuuuucgu ugguguaaag ccaacacccu gucuaaaaaa      120

cauaaauuuc uuuaaucauu uugccucuuu ucucugugcu ucaauuaaua aaaaauggaa      180

agaaccu                                                                187


<210>  80
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  muag 3'-UTR

<400>  80
gcccgatggg cctcccaacg ggccctcctc ccctccttgc accg                        44


<210>  81
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  muag 3'-UTR

<400>  81
gcccgauggg ccucccaacg ggcccuccuc cccuccuugc accg                        44


<210>  82
<211>  2035
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PpLuc

<400>  82
ggggcgcugc cuacggaggu ggcagccauc uccuucucgg caucaagcuu gaggauggag       60

gacgccaaga acaucaagaa gggcccggcg cccuucuacc cgcuggagga cgggaccgcc      120

ggcgagcagc uccacaaggc caugaagcgg uacgcccugg ugccgggcac gaucgccuuc      180

accgacgccc acaucgaggu cgacaucacc uacgcggagu acuucgagau gagcgugcgc      240

cuggccgagg ccaugaagcg guacggccug aacaccaacc accggaucgu ggugugcucg      300

gagaacagcc ugcaguucuu caugccggug cugggcgccc ucuucaucgg cguggccguc      360

gccccggcga acgacaucua caacgagcgg gagcugcuga acagcauggg gaucagccag      420

ccgaccgugg uguucgugag caagaagggc cugcagaaga uccugaacgu gcagaagaag      480

cugcccauca uccagaagau caucaucaug gacagcaaga ccgacuacca gggcuuccag      540

ucgauguaca cguucgugac cagccaccuc ccgccgggcu ucaacgagua cgacuucguc      600

ccggagagcu ucgaccggga caagaccauc gcccugauca ugaacagcag cggcagcacc      660

ggccugccga aggggguggc ccugccgcac cggaccgccu gcgugcgcuu cucgcacgcc      720

cgggacccca ucuucggcaa ccagaucauc ccggacaccg ccauccugag cguggugccg      780

uuccaccacg gcuucggcau guucacgacc cugggcuacc ucaucugcgg cuuccgggug      840

guccugaugu accgguucga ggaggagcug uuccugcgga gccugcagga cuacaagauc      900

cagagcgcgc ugcucgugcc gacccuguuc agcuucuucg ccaagagcac ccugaucgac      960

aaguacgacc ugucgaaccu gcacgagauc gccagcgggg gcgccccgcu gagcaaggag     1020

gugggcgagg ccguggccaa gcgguuccac cucccgggca uccgccaggg cuacggccug     1080

accgagacca cgagcgcgau ccugaucacc cccgaggggg acgacaagcc gggcgccgug     1140

ggcaaggugg ucccguucuu cgaggccaag gugguggacc uggacaccgg caagacccug     1200

ggcgugaacc agcggggcga gcugugcgug cgggggccga ugaucaugag cggcuacgug     1260

aacaacccgg aggccaccaa cgcccucauc gacaaggacg gcuggcugca cagcggcgac     1320

aucgccuacu gggacgagga cgagcacuuc uucaucgucg accggcugaa gucgcugauc     1380

aaguacaagg gcuaccaggu ggcgccggcc gagcuggaga gcauccugcu ccagcacccc     1440

aacaucuucg acgccggcgu ggccgggcug ccggacgacg acgccggcga gcugccggcc     1500

gcgguggugg ugcuggagca cggcaagacc augacggaga aggagaucgu cgacuacgug     1560

gccagccagg ugaccaccgc caagaagcug cggggcggcg ugguguucgu ggacgagguc     1620

ccgaagggcc ugaccgggaa gcucgacgcc cggaagaucc gcgagauccu gaucaaggcc     1680

aagaagggcg gcaagaucgc cguguaagac uagugcauca cauuuaaaag caucucagcc     1740

uaccaugaga auaagagaaa gaaaaugaag aucaauagcu uauucaucuc uuuuucuuuu     1800

ucguuggugu aaagccaaca cccugucuaa aaaacauaaa uuucuuuaau cauuuugccu     1860

cuuuucucug ugcuucaauu aauaaaaaau ggaaagaacc uagaucuaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa augcaucccc     1980

cccccccccc cccccccccc cccccccaaa ggcucuuuuc agagccacca gaauu          2035


<210>  83
<211>  1929
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  PpLuc

<400>  83
aggagagucc cgcagucggc guccagcggc ucugcuuguu cgugugugug ucguugcagg       60

ccuuauucaa gcuuaccaug gaggacgcca agaacaucaa gaagggcccg gcgcccuucu      120

acccgcugga ggacgggacc gccggcgagc agcuccacaa ggccaugaag cgguacgccc      180

uggugccggg cacgaucgcc uucaccgacg cccacaucga ggucgacauc accuacgcgg      240

aguacuucga gaugagcgug cgccuggccg aggccaugaa gcgguacggc cugaacacca      300

accaccggau cguggugugc ucggagaaca gccugcaguu cuucaugccg gugcugggcg      360

cccucuucau cggcguggcc gucgccccgg cgaacgacau cuacaacgag cgggagcugc      420

ugaacagcau ggggaucagc cagccgaccg ugguguucgu gagcaagaag ggccugcaga      480

agauccugaa cgugcagaag aagcugccca ucauccagaa gaucaucauc auggacagca      540

agaccgacua ccagggcuuc cagucgaugu acacguucgu gaccagccac cucccgccgg      600

gcuucaacga guacgacuuc gucccggaga gcuucgaccg ggacaagacc aucgcccuga      660

ucaugaacag cagcggcagc accggccugc cgaagggggu ggcccugccg caccggaccg      720

ccugcgugcg cuucucgcac gcccgggacc ccaucuucgg caaccagauc aucccggaca      780

ccgccauccu gagcguggug ccguuccacc acggcuucgg cauguucacg acccugggcu      840

accucaucug cggcuuccgg gugguccuga uguaccgguu cgaggaggag cuguuccugc      900

ggagccugca ggacuacaag auccagagcg cgcugcucgu gccgacccug uucagcuucu      960

ucgccaagag cacccugauc gacaaguacg accugucgaa ccugcacgag aucgccagcg     1020

ggggcgcccc gcugagcaag gaggugggcg aggccguggc caagcgguuc caccucccgg     1080

gcauccgcca gggcuacggc cugaccgaga ccacgagcgc gauccugauc acccccgagg     1140

gggacgacaa gccgggcgcc gugggcaagg uggucccguu cuucgaggcc aagguggugg     1200

accuggacac cggcaagacc cugggcguga accagcgggg cgagcugugc gugcgggggc     1260

cgaugaucau gagcggcuac gugaacaacc cggaggccac caacgcccuc aucgacaagg     1320

acggcuggcu gcacagcggc gacaucgccu acugggacga ggacgagcac uucuucaucg     1380

ucgaccggcu gaagucgcug aucaaguaca agggcuacca gguggcgccg gccgagcugg     1440

agagcauccu gcuccagcac cccaacaucu ucgacgccgg cguggccggg cugccggacg     1500

acgacgccgg cgagcugccg gccgcggugg uggugcugga gcacggcaag accaugacgg     1560

agaaggagau cgucgacuac guggccagcc aggugaccac cgccaagaag cugcggggcg     1620

gcgugguguu cguggacgag gucccgaagg gccugaccgg gaagcucgac gcccggaaga     1680

uccgcgagau ccugaucaag gccaagaagg gcggcaagau cgccguguga ggacuagucc     1740

cuguucccag agcccacuuu uuuuucuuuu uuugaaauaa aauagccugu cuuucagauc     1800

uaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaugcau cccccccccc cccccccccc cccccccccc caaaggcucu uuucagagcc     1920

accagaauu                                                             1929


<210>  84
<211>  547
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Immune stimulatory RNA

<400>  84
gggagaaagc ucaagcuuau ccaaguaggc uggucaccug uacaacguag ccgguauuuu       60

uuuuuuuuuu uuuuuuuuga ccgucucaag guccaaguua gucugccuau aaaggugcgg      120

auccacagcu gaugaaagac uugugcggua cgguuaaucu ccccuuuuuu uuuuuuuuuu      180

uuuuuaguaa augcgucuac ugaauccagc gaugaugcug gcccagaucu ucgaccacaa      240

gugcauauag uagucaucga gggucgccuu uuuuuuuuuu uuuuuuuuuu uggcccaguu      300

cugagacuuc gcuagagacu acaguuacag cugcaguagu aaccacugcg gcuauugcag      360

gaaaucccgu ucagguuuuu uuuuuuuuuu uuuuuuccgc ucacuaugau uaagaaccag      420

guggaguguc acugcucucg aggucucacg agagcgcucg auacaguccu uggaagaauc      480

uuuuuuuuuu uuuuuuuuuu uugugcgacg aucacagaga acuucuauuc augcaggucu      540

gcucuag                                                                547


<210>  85
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  85
gagcngcca                                                                9


<210>  86
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  7mer oligonucleotide


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  86
agcngcc                                                                  7


<210>  87
<211>  5
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5mer oligonucleotide


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  87
gcngc                                                                    5


<210>  88
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  88
gugggguucc cgagcngcca aaggga                                            26


<210>  89
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 17 A


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  89
gugggguucc cgagangcca aaggga                                            26


<210>  90
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 17 G


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  90
gugggguucc cgaggngcca aaggga                                            26


<210>  91
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 17 U


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  91
gugggguucc cgagungcca aaggga                                            26


<210>  92
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 17 A


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  92
gugggguucc cgagcngcca aaggga                                            26


<210>  93
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 17 C


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  93
gugggguucc cgagcngcca aaggga                                            26


<210>  94
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 17 U


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  94
gugggguucc cgagcngcca aaggga                                            26


<210>  95
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 19 A


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  95
gugggguucc cgagcnacca aaggga                                            26


<210>  96
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 19 C


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  96
gugggguucc cgagcnccca aaggga                                            26


<210>  97
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 19 U


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  97
gugggguucc cgagcnucca aaggga                                            26


<210>  98
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 20 A


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  98
gugggguucc cgagcngaca aaggga                                            26


<210>  99
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 20 G


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  99
gugggguucc cgagcnggca aaggga                                            26


<210>  100
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  26mer oligonucleotide 20 U


<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  100
gugggguucc cgagcnguca aaggga                                            26


<210>  101
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mU


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (17)..(19)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  101
cnacacaaan cagcgannnu u                                                 21


<210>  102
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mC


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  102
nuananaaau nagngauuuu u                                                 21


<210>  103
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mG


<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  103
cuacacaaau cancnauuuu u                                                 21


<210>  104
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mA


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  104
cuncncnnnu cngcgnuuuu u                                                 21


<210>  105
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NP-mU


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (9)..(11)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  105
ggancnnann ncnncggagu u                                                 21


<210>  106
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  NP-mC


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  106
ggaunuuauu unuunggagu u                                                 21


<210>  107
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Luc-mU


<220>
<221>  modified_base
<222>  (3)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  107
gannangncc ggnnangnau u                                                 21


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2216 (PO)

<400>  108
gggggacgat cgtcgggggg                                                   20


<210>  109
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN M362 (PO)

<400>  109
tcgtcgtcgt tcgaacgacg ttgat                                             25


<210>  110
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 6295 (PO)

<400>  110
taacgttgag gggcat                                                       16


<210>  111
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 1826 (PO)

<400>  111
tccatgacgt tcctgacgtt                                                   20


<210>  112
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRS-954 (DV-1079)

<400>  112
ugcuccugga gggguugu                                                     18


<210>  113
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRO-5

<400>  113
cuaucugacg uucucugu                                                     18


<210>  114
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRS 2088

<400>  114
uccuggcggg gaagu                                                        15


<210>  115
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRS 869

<400>  115
uccuggaggg guugu                                                        15


<210>  116
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN-2114

<400>  116
uccuggaggg gaagu                                                        15


<210>  117
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN 4024

<400>  117
uccuggaugg gaagu                                                        15


<210>  118
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN 4084-F

<400>  118
ccuggauggg aa                                                           12


<210>  119
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRS-661

<400>  119
ugcuugcaag cuugcaagca                                                   20


<210>  120
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IRS-954

<400>  120
ugcuccugga gggguugu                                                     18


<210>  121
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN-24888

<400>  121
uccuggcggg gaagu                                                        15


<210>  122
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  IHN-ODN 2088

<400>  122
uccuggcggg gaagu                                                        15


<210>  123
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ODN A151

<400>  123
uuaggguuag gguuaggguu aggg                                              24


<210>  124
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  G-ODN

<400>  124
cuccuauugg ggguuuccua u                                                 21


<210>  125
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ODN INH-1

<400>  125
ccuggauggg aauucccauc cagg                                              24


<210>  126
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ODN INH-18

<400>  126
ccuggauggg aacuuaccgc ugca                                              24


<210>  127
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-4

<400>  127
uucccaucca ggccuggaug ggaa                                              24


<210>  128
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-13

<400>  128
cuuaccgcug caccuggaug ggaa                                              24


<210>  129
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  (pS-) ST-ODN

<400>  129
ucgucguuuu gucguuuugu cguu                                              24


<210>  130
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN 21 14

<400>  130
uccuggaggg gaagu                                                        15


<210>  131
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Endosomal TLR Targets TLR7

<400>  131
uccuggaggg guugu                                                        15


<210>  132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Endosomal TLR Targets TLR9

<400>  132
ugcuugcaag cuugcaagca                                                   20


<210>  133
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Endosomal TLR Targets TLR7 and 9

<400>  133
ugcuccugga gggguugu                                                     18


<210>  134
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 1


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  134
gnuacuuacc ug                                                           12


<210>  135
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 2


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  135
ccgagccnaa ggcacc                                                       16


<210>  136
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 3


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  136
nnuacuuacc ug                                                           12


<210>  137
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 4


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  137
nauacuuacc ug                                                           12


<210>  138
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 5


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  138
ccgngccgau uguacc                                                       16


<210>  139
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 6


<220>
<221>  modified_base
<222>  (9)..(9)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  139
ccgagccgnu uguacc                                                       16


<210>  140
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 7


<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  140
ccgagccgan uguacc                                                       16


<210>  141
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 8


<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  141
ccgagccgau nguacc                                                       16


<210>  142
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 9


<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  142
ccgagccgau unuacc                                                       16


<210>  143
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 10


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  143
ccgagccnau uguacc                                                       16


<210>  144
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 11


<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  144
ccgagccgau uguanc                                                       16


<210>  145
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 12


<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  145
ccgagccgau uguanc                                                       16


<210>  146
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 13


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  146
ccgagcngau uguacc                                                       16


<210>  147
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 14


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  147
ccgagccncu uguccc                                                       16


<210>  148
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  modified ORN 15


<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  148
ccgagccgcu ugnccc                                                       16


<210>  149
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  149
gagangcca                                                                9


<210>  150
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  150
gaggngcca                                                                9


<210>  151
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Am


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  151
gagungcca                                                                9


<210>  152
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Cm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  152
gagcngcca                                                                9


<210>  153
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Um


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  153
gagcngcca                                                                9


<210>  154
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  154
gagcnacca                                                                9


<210>  155
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  155
gagcnccca                                                                9


<210>  156
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  156
gagcnucca                                                                9


<210>  157
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  157
gagcngaca                                                                9


<210>  158
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  158
gagcnggca                                                                9


<210>  159
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  159
gagcnguca                                                                9


<210>  160
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  160
gagcgncca                                                                9


<210>  161
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  161
gagcggnca                                                                9


<210>  162
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  162
gagcggcna                                                                9


<210>  163
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  163
gagnggcca                                                                9


<210>  164
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  164
gancggcca                                                                9


<210>  165
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  165
gngcggcca                                                                9


<210>  166
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS-954 (DV-1079)

<400>  166
tgctcctgga ggggttgt                                                     18


<210>  167
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRO-5

<400>  167
ctatctgacg ttctctgt                                                     18


<210>  168
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS 2088

<400>  168
tcctggcggg gaagt                                                        15


<210>  169
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS 869

<400>  169
tcctggaggg gttgt                                                        15


<210>  170
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN-2114

<400>  170
tcctggaggg gaagt                                                        15


<210>  171
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN 4024

<400>  171
tcctggatgg gaagt                                                        15


<210>  172
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN 4084-F

<400>  172
cctggatggg aa                                                           12


<210>  173
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS-661

<400>  173
tgcttgcaag cttgcaagca                                                   20


<210>  174
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS-954

<400>  174
tgctcctgga ggggttgt                                                     18


<210>  175
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN-24888

<400>  175
tcctggcggg gaagt                                                        15


<210>  176
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IHN-ODN 2088

<400>  176
tcctggcggg gaagt                                                        15


<210>  177
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN A151

<400>  177
ttagggttag ggttagggtt aggg                                              24


<210>  178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G-ODN

<400>  178
ctcctattgg gggtttccta t                                                 21


<210>  179
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN INH-1

<400>  179
cctggatggg aattcccatc cagg                                              24


<210>  180
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN INH-18

<400>  180
cctggatggg aacttaccgc tgca                                              24


<210>  181
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-4

<400>  181
ttcccatcca ggcctggatg ggaa                                              24


<210>  182
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-13

<400>  182
cttaccgctg cacctggatg ggaa                                              24


<210>  183
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (pS-) ST-ODN

<400>  183
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  184
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN 21 14

<400>  184
tcctggaggg gaagt                                                        15


<210>  185
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ndufa1(G51C) 3'-UTR

<400>  185
ggaagcattt tcctggctga ttaaaagaaa ttactcagct atggtcatct cttcctgtta       60

gaaggctatg cagcatatta tatactatgc gcatgttatg aaatgcataa taaaaaattt      120

taaaaaatct aaa                                                         133


<210>  186
<211>  133
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Ndufa1(G51C) 3'-UTR

<400>  186
ggaagcauuu uccuggcuga uuaaaagaaa uuacucagcu auggucaucu cuuccuguua       60

gaaggcuaug cagcauauua uauacuaugc gcauguuaug aaaugcauaa uaaaaaauuu      120

uaaaaaaucu aaa                                                         133


<210>  187
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm PTO (Gm18 variant 1)


<220>
<221>  modified_base
<222>  (1)..(9)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  187
gagcngcca                                                                9


<210>  188
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm (Gm18 variant 3)


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  188
gcngccaaa                                                                9


<210>  189
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm PTO (Gm18 variant 4)


<220>
<221>  modified_base
<222>  (1)..(9)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  189
gcngccaaa                                                                9


<210>  190
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  190
ccgagcngc                                                                9


<210>  191
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  9mer oligonucleotide Gm, m6a


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  wherein n is N6-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  wherein n is N6-methyladenosine

<400>  191
gngcngccn                                                                9


<210>  192
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  12mer oligonucleotide Gm, ac4c


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  wherein n is 4-acetylcytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  wherein n is 4-acetylcytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  wherein n is 4-acetylcytidine

<400>  192
gagcnngcnc na                                                           12


<210>  193
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2088 PTO (DNA oligo 1)


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<400>  193
tcctggcggg gaagt                                                        15


<210>  194
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2088 control (ODN 20959) PTO (DNA oligo 2)


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<400>  194
taatggcggg gaagt                                                        15


<210>  195
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2088 control (ODN 2087) PTO


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<400>  195
tcctgagctt gaagt                                                        15


<210>  196
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2088 control (ODN 20958) PTO


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<400>  196
tcctaacaaa aaaat                                                        15


<210>  197
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS-954 (DV-1079) PTO


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<400>  197
tgctcctgga ggggttgt                                                     18


<210>  198
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRS-661 PTO


<220>
<221>  modified_base
<222>  (1)..(20)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<400>  198
tgcttgcaag cttgcaagca                                                   20


<210>  199
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INH-ODN-24888 PTO Em PTO


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  wherein n is 7-deaza-2'-O-methyl-guanine

<400>  199
tcctggcngg gaagt                                                        15


<210>  200
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRO-5


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  200
ctatctnncg ttctctgt                                                     18


<210>  201
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SM-MePS PTO (RNA oligo 1)


<220>
<221>  modified_base
<222>  (1)..(17)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  201
nnannuuunn ggunnuu                                                      17


<210>  202
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  12mer oligonucleotide Um PTO


<220>
<221>  modified_base
<222>  (1)..(12)
<223>  wherein all internucleotidelinkages are phosphothioate linkages

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  202
ganacuuacc ug                                                           12


<210>  203
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  18mer oligonucleotide Um, Gm, Cm, Am (RNA oligo 5)


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (11)..(14)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  203
nnnnnnnnnn nnnnnnnu                                                     18


<210>  204
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  2OMe 2 xG(S) (RNA oligo 3)


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  204
uugaununuu uagucgcuau u                                                 21


<210>  205
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  27mer oligonucleotide Gm (RNA oligo 4)


<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated guanosine

<400>  205
ggugggguuc ccgagcngcc aaaggga                                           27


<210>  206
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  10-mer (Um)


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (8)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  206
ggncnacnnn                                                              10


<210>  207
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  (mU)21


<220>
<221>  modified_base
<222>  (1)..(21)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  207
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  208
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  (mU)15


<220>
<221>  modified_base
<222>  (1)..(15)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  208
nnnnnnnnnn nnnnn                                                        15


<210>  209
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  (mU)10


<220>
<221>  modified_base
<222>  (1)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  209
nnnnnnnnnn                                                              10


<210>  210
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mU


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<220>
<221>  modified_base
<222>  (17)..(19)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated uracil

<400>  210
cnacacaaan cagcgannnu u                                                 21


<210>  211
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mC


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated cytosine

<400>  211
nuananaaau nagngauuuu u                                                 21


<210>  212
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gal-mA


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (7)..(9)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n can be any nucleotide, wherein the nucleotide is 
       2-O-methylated, preferably a 2-O-methylated adenosine

<400>  212
cuncncnnnu cngcgnuuuu u                                                 21


