                               SEQUENCE LISTING

<110> MODMAB THERAPEUTICS INC.
 
<120> ANTIBODIES THAT BIND TO LRP6 PROTEINS AND METHODS OF USE

<130> 27690-P62374PC00/MODM-006-PCT

<140>
<141>

<150> 62/886,918
<151> 2019-08-14

<160> 47    

<170> PatentIn version 3.5

<210> 1
<211> 7
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      LRP5/6 phosphorylation site sequence


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 1
Pro Pro Pro Ser Pro Xaa Ser 
1               5           


<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Leu Ser Tyr Tyr Tyr Ile 
1               5       


<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Ile Ala Ser Tyr Ser Ser Ile 
1               5           


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Leu Tyr Tyr Tyr Ser Met 
1               5       


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ile Ser Ser Tyr Tyr Ile 
1               5       


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Ser 
1               5                   10  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Tyr Ile Ser Ser Tyr Tyr Gly Tyr Thr Tyr 
1               5                   10  


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Tyr 
1               5                   10  


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Tyr 
1               5                   10  


<210> 10
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser Gly Trp Ala Met 
1               5                   10                  15  


<210> 11
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ala His Tyr Phe Pro Trp Ala Gly Ala Met 
1               5                   10  


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Ser Tyr Phe Pro Trp Phe Ser Ala Met 
1               5                   10  


<210> 13
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Tyr Ala Gly Tyr Tyr Tyr Tyr Pro Trp Ala Tyr Tyr Gly Trp Pro Phe 
1               5                   10                  15      


Ser Gly Leu 
            


<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Ser Val Ser Ser Ala 
1               5   


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Ser Ala Ser Ser Leu Tyr Ser 
1               5           


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Tyr Tyr Ser Pro Ile 
1               5   


<210> 17
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Tyr Ser Trp Gly Pro Phe 
1               5       


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Tyr Tyr Phe Leu Ile 
1               5   


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Ala Gly Ser Ala Pro Tyr His Leu Ile 
1               5                   


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Tyr Tyr Trp Pro Ile 
1               5   


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Ala Ala Tyr His Trp Pro Pro Leu Phe 
1               5                   


<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Leu Tyr Tyr Thr Asp Met 
1               5       


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ser Ile Ser Leu Phe Phe Gly Tyr Val Ser 
1               5                   10  


<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Tyr Leu Ala Met 
1               


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ile Ser Tyr Ser Ser Ile 
1               5       


<210> 26
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Ile Tyr Ser Tyr Tyr Ile 
1               5       


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Ser Ile Tyr Ser Ser Tyr Ser Tyr Thr Ser 
1               5                   10  


<210> 28
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctct tattattata tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt cttatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcactgtt      300

cgtggatcca aaaaaccgta cttctctggt tgggctatgg actactgggg tcaaggaacc      360

ctggtcaccg tctcctcg                                                    378


<210> 29
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Ser Tyr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser Gly Trp Ala 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 30
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tactactggc cgatcacgtt cggacagggt      300

accaaggtgg agatcaaacg t                                                321


<210> 31
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Trp Pro Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210> 32
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tattcttcta tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatat atttcttctt attatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcgctcat      300

tacttcccgt gggctggtgc tatggactac tggggtcaag gaaccctggt caccgtctcc      360

tcg                                                                    363


<210> 33
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Ser 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala His Tyr Phe Pro Trp Ala Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 34
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tactcttggg gtccgttcac gttcggacag      300

ggtaccaagg tggagatcaa acgt                                             324


<210> 35
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Trp Gly Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 36
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tattcttcta tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttctcctt attatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctcttct      300

tacttcccgt ggttctctgc tatggactac tggggtcaag gaaccctggt caccgtctcc      360

tcg                                                                    363


<210> 37
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Tyr Ser 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Tyr Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ser Tyr Phe Pro Trp Phe Ser Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 38
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa tactacttcc tgatcacgtt cggacagggt      300

accaaggtgg agatcaaacg t                                                321


<210> 39
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Phe Leu Ile Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210> 40
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacctctat tattattcta tgcactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt cttatggcta tacttattat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgctacgct      300

ggttactact actacccgtg ggcttactac ggttggccgt tctctggttt ggactactgg      360

ggtcaaggaa ccctggtcac cgtctcctcg                                       390


<210> 41
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Tyr Tyr Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ala Gly Tyr Tyr Tyr Tyr Pro Trp Ala Tyr Tyr Gly Trp 
            100                 105                 110         


Pro Phe Ser Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 42
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
gatatccaga tgacccagtc cccgagctcc ctgtccgcct ctgtgggcga tagggtcacc       60

atcacctgcc gtgccagtca gtccgtgtcc agcgctgtag cctggtatca acagaaacca      120

ggaaaagctc cgaagcttct gatttactcg gcatccagcc tctactctgg agtcccttct      180

cgcttctctg gtagccgttc cgggacggat ttcactctga ccatcagcag tctgcagccg      240

gaagacttcg caacttatta ctgtcagcaa gctggttctg ctccgtacca tctgatcacg      300

ttcggacagg gtaccaaggt ggagatcaaa cgt                                   333


<210> 43
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Gly Ser Ala Pro Tyr 
                85                  90                  95      


His Leu Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110     


<210> 44
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 44
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctct tcttattata tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt cttatggcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcactgtt      300

cgtggatcca aaaaaccgta cttctctggt tgggctatgg actactgggg tcaaggaacc      360

ctggtcaccg tctcctcg                                                    378


<210> 45
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Gly Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser Gly Trp Ala 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210> 46
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
gaggttcagc tggtggagtc tggcggtggc ctggtgcagc cagggggctc actccgtttg       60

tcctgtgcag cttctggctt caacatctat tcttattata tccactgggt gcgtcaggcc      120

ccgggtaagg gcctggaatg ggttgcatct atttattctt cttatagcta tacttcttat      180

gccgatagcg tcaagggccg tttcactata agcgcagaca catccaaaaa cacagcctac      240

ctacaaatga acagcttaag agctgaggac actgccgtct attattgtgc tcgcactgtt      300

cgtggatcca aaaaaccgta cttctctggt tgggctatgg actactgggg tcaaggaacc      360

ctggtcaccg tctcctcg                                                    378


<210> 47
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Tyr Ser Ser Tyr Ser Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Val Arg Gly Ser Lys Lys Pro Tyr Phe Ser Gly Trp Ala 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


