                         SEQUENCE LISTING

<110>  On. Target Molecules Biotech Inc.
 
<120>  FUSION PROTEINS AGAINST SIALOSYLATED GLYCOSPHINGOLIPIDS AND 
       SIALATED GLYCOPROTEINS AND USES THEREOF

<130>  31429/54632

<150>  US 62/884,585
<151>  2019-08-08

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Tyr Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Tyr Tyr Gly Ser Ser Tyr Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  3
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3

Gly Gly Thr Thr Thr Gly Gly Cys Thr Gly Gly Cys Gly Gly Gly Cys 
1               5                   10                  15      


Cys Cys Cys Thr Ala Gly Gly Ala Ala Thr Gly Cys Thr Cys Thr Cys 
            20                  25                  30          


Cys Thr Cys Cys Cys Cys Gly Cys Cys Cys Cys Cys Gly Gly Cys Cys 
        35                  40                  45              


Cys Ala Ala Ala Gly Thr Gly Cys Cys Ala Cys Gly 
    50                  55                  60  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gly Phe Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ile Arg Leu Arg Ser Asp Asp Tyr Ala Thr 
1               5                   10  


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Thr Gly Pro Ala Asn Trp Gly Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Gln Ser Ile Val Gln Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  8
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Lys Val Ser 
1           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Ile Tyr Pro Gly Asn Ser Asp Thr 
1               5               


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Thr Arg Arg Gly Tyr Tyr Tyr Gly Ser Ser Ser His Phe Asp Tyr 
1               5                   10                  15  


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Lys Val Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Leu Arg Ser Asp Asp Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Pro Ala Asn Trp Gly Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Thr 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  18
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr His Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Arg Gly Tyr Tyr Tyr Gly Ser Ser Ser His Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gly Gly Gly 
1           


<210>  22
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  22

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  23
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Ile Arg Leu Arg Ser Asp Asp Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Gly Pro Ala Asn Trp Gly Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Arg Ser Ser Gln Ser Ile Val Gln Thr Asn Gly Asn Thr Tyr Leu Glu 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys 
            180                 185                 190         


Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
465                 470                 475                 480 


Gly Gly Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro 
                485                 490                 495     


Gly Ala Ser Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
            500                 505                 510         


Ser Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        515                 520                 525             


Trp Ile Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln 
    530                 535                 540                 


Lys Phe Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr 
545                 550                 555                 560 


Ala Tyr Met Glu Leu Ser Ser Leu Thr His Glu Asp Ser Ala Val Tyr 
                565                 570                 575     


Tyr Cys Thr Arg Arg Gly Tyr Tyr Tyr Gly Ser Ser Ser His Phe Asp 
            580                 585                 590         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr 
    610                 615                 620                 


Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
625                 630                 635                 640 


Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
                645                 650                 655     


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
            660                 665                 670         


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
        675                 680                 685             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
    690                 695                 700                 


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Pro 
705                 710                 715                 720 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                725                 730     


<210>  24
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
gaagtgaagc ttgaggagtc tggaggaggc ttggtgcaac ctggaggatc catgaaactc       60

tcctgtgttg cctctggatt cactttcagt aactactgga tgaactgggt ccgccagtct      120

ccagagaagg ggcttgagtg ggttgctcaa attagattga gatctgatga ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc ccaaagtagt      240

gtctacctgc aaatgaacaa cttaagggct gaagacactg gaatttatta ctgcacaggc      300

cccgctaact ggggttactg gtacttcgat gtctggggca cagggaccac ggtcaccgtc      360

tcctcaggtg gcggaggatc tggcggaggc ggtagtggcg gtggcggatc tgatgttttg      420

atgacccaaa ctccactctc cctgcctgtc agtcttggag atcaagcctc catctcttgc      480

agatctagtc agagcattgt acagactaat ggaaacacct atttagaatg gtacctgcag      540

aaaccaggcc agtctccaaa gctcctgatc tacaaagttt ccaaccgatt ttctggggtc      600

ccagacaggt tcagtggcag tggatcaggg acagatttca cactcaagat cagtagagtg      660

gaggctgagg atctgggagt ttattactgc tttcaaggtt cacatgttcc gctcacgttc      720

ggtgctggga ccaagctgga gctgaaaggc ggtggagaca aaactcacac atgcccaccg      780

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      840

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      900

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      960

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1020

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1080

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1140

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1200

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1260

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1320

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1380

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaggc     1440

ggaggtgagg ttcagctcca gcagtctggg actgtgctgg caaggcctgg ggcttcagtg     1500

aagatgtcct gcaagacttc tggctacaca tttaccagct actggatgca ctgggtaaaa     1560

cagaggcctg gacagggtct ggaatggata ggggctattt atcctggaaa tagtgatact     1620

agctacaacc agaagttcaa gggcaaggcc aaactgactg cagtcacatc cgccagcact     1680

gcctacatgg agctcagcag cctgacacat gaggactctg cggtctatta ctgtacaaga     1740

aggggctatt actacggtag tagctcccac tttgactact ggggccaagg caccactctc     1800

acagtctcct caggtggcgg aggatctggc ggaggcggta gtggcggtgg cggatctgat     1860

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc     1920

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt acattggtac     1980

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct     2040

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc     2100

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttcctccg     2160

acgttcggtg gaggcaccaa gctggaaatc aaatga                               2196


<210>  25
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
actagtgttc atcggagccc aggtttactc ccttaagtgg aaatttcttc ccccactccc       60

tccttggctt tctccaagga gggaacccag gctactggaa agtccggctg gggcggggac      120

tgtgggtttc agggtagaac tgcgtgtgga acgggacagg gagcggttag aagggtgggg      180

ctattccggg aagtggtggg gggagggagc ccaaaactag cacctagtcc actcattatc      240

cagccctctt atttctcggc cccgctctgc ttcagtggac ccggggaggg cggggaagtg      300

gagtgggaga cctaggggtg ggcttcccga ccttgctgta caggacctcg acctagctgg      360

ctttgttccc catccccacg ttagttgttg ccctgaggct aaaactagag cccaggggcc      420

ccaagttcca gactgcccct cccccctccc ccggagccag ggagtggttg gtgaaagggg      480

gaggccagct ggagaacaaa cgggtagtca gggggttgag cgattagagc ccttgtaccc      540

tacccaggaa tggttgggga ggaggaggaa gaggtaggag gtaggggagg gggcggggtt      600

ttgtcacctg tcacctgctc cggctgtgcc tagggcgggc gggcggggag tggggggacc      660

ggtataaagc ggtaggcgcc tgtgcccgct ccacctctca agcagccagc gcctgcctga      720

atctgttctg ccccctcccc acccatttca ccaccacc                              758


<210>  26
<211>  2393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
ctagtactat gctgcacaag caatttaaaa caccaacagc aaaaaaatac acttctctga       60

aaaagtcttg gtctaggacc taaacaattg cctgaaactg ggtagactta caccaatgag      120

aggcagataa agagattaag attgagggag tagggcaggg cttgcaatgg tgccggccag      180

gatgtggctg agggggtgtg ggtgcctgcc gtggatgcta gggtagaaga cgactctatt      240

aactgggtgg ctgtaagcag tacccaggtc aatgcctttc atcttctaca acctcgacgt      300

tgcctggaat cctaaatctt tttcttcact taacaaacat cacctctgct caaatctgca      360

actgctttga tatcacactg cctttttcac ccctctatta tagatggcat ttatttactt      420

acatgttttt tccccactag actatactcc ttgagaacag cgattgtgtc ttatttattt      480

ctgaatcacc aattcagaca ggcatgcaaa cacttgttga accaatgcac aaatatattt      540

tgctcttctt catagattcc tccggcctca gatgaccagg caccactaga tacagaacac      600

tgtgctttcc ttctccaagg taaaggaata aatatctgtt ccccttcatg aagtgttact      660

gttgggcctt tatgccatcc tgaagccacc aggatgtgga accagatcag ggaggtccac      720

agttacaacc ccttgtatct gtaacaccag caggacatta tctacagagt cctgctgcag      780

ggccccgaat gaagacagca ttttgctgct ttgtagcgtg agcagtgctg taacagtgat      840

gcatggatgt tcctctggtg tcctgaaaga atgtaggtgc ttcttgaaag ctctctgcaa      900

cttattaatt gggagtgatt atgcgatgga gaaaacagag tcccatcacc ccctcagtct      960

tccctgggaa atcacaagag ggctgatagc tctctgtgag gtgaaccgtt tctagaatcc     1020

ccaccgtctc gtcctgttct tccgcccacc cagttcctca agatagcccc tgtgggcttc     1080

tgatgaagtc accacaccac tggctaatga agtagataaa ccagaacagt ttggtttaac     1140

atttaaggtc agaaacagga actttctaga ggagaaatca aaaaagcaaa agaagtataa     1200

gggcagccct ccaaccagtc agaataccgt gaccacctga gaggcccgtg gcccagcgga     1260

cacggacgca tgtcaactct ggagcagata tcttcagcgc agcatctgac ctgggagtac     1320

agccacatac cctcattcct aaacggcaga ttgactactg cagccacaca cagtctccgg     1380

gcaatgtgga gacatgtcta atatttagtc aacataactc agggtgccac agtcttcaca     1440

actgttgtga gcacttgagg atgctgcatt tgaagatagg aatttgccct caagcatctg     1500

gggtttgggt acagaacaga gcttcccctg ccaccacctg ctaattttat aaaatgtgca     1560

ttcaaaaaaa aatcctgcct gtaagaagga attaagctac ccatttaaat ataacagctg     1620

cctgtgcaat ctactgctgc tctttatagg aaacgcttaa ataattgaga tacttaattg     1680

ggttaaagag atccctagca catagatgtt ctataaataa aagaatgagt aaataatcta     1740

gtaaccttcc ttttcatgtc cttcacttaa agagatcgtt ctgttttgtt tgcaccaata     1800

agatcactgt tagaggactc cagagaggtt tgatttcagg tggggtgggg ctttcccaag     1860

gaagtccctt ttcatttgtt tcaggtgtac tgccaccttt ttccctggct ctttcactaa     1920

aaatgaaaaa tttgttgatc tttgctgtaa gtaggtaggc atctgggctt tgcttttgca     1980

actagagtca aagaagtcaa gttatcaggc tgatcttgcc ttgctatcta gaatcagaaa     2040

ggtttaagta gcccagggac tactcaaaga cagctggagg agaaagggag agagaaaaat     2100

gcttataaag aggtgggcaa aagagcggga ccttgtctca aaaaaaaaaa aaaaaaagag     2160

gaagtggtag gaggtgtctg aatttcactg tgacctgttc tgtcaggtga tttttggtgg     2220

ggcggggaca tgaaaaaaaa gttaaaatgt ccttataaag acaaaatctt tttctttcct     2280

ggctgatgat ttgtcattct agtcacttcc tgccttgtga ccacacaccc aggcttgaca     2340

aagctgttct gcagatcaga aagaaggggt tcctggtcat acaccagtac tac            2393


<210>  27
<211>  428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gccctggaga gcatggggag acccgggacc ctgctgggtt tctctgtcac aaaggaaaat       60

aatccccctg gtgtgacaga cccaaggaca gaacacagca gaggtcagca ctggggaaga      120

caggttgtcc tcccagggga tgggggtcca tccaccttgc cgaaaagatt tgtctgagga      180

actgaaaata gaagggaaaa aagaggaggg acaaaagagg cagaaatgag aggggagggg      240

acagaggaca cctgaataaa gaccacaccc atgacccacg tgatgctgag aagtactcct      300

gccctaggaa gagactcagg gcagagggag gaaggacagc agaccagaca gtcacagcag      360

ccttgacaaa acgttcctgg aactcaagct cttctccaca gaggaggaca gagcagacag      420

cagagacc                                                               428


<210>  28
<211>  1567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ttgaggtacc tggtgtagtt ttatttcagg ttttatgctg tcattttcct gtaatgctaa       60

ggacttagga cataactgaa ttttctattt tccacttctt ttctggtgtg tgtgtatata      120

tatatgtata tatacacaca cacatgtaca tatatatatt ttttagtatc tcaccctcac      180

atgctcctcc ctgagcacta cccatgatag atgttaaaca aaagcaaaga tgaaattcca      240

actgtcaaaa tctcccttcc atctaattaa ttcctcatcc aactatgttc caaaacgaga      300

atagaaaatt agccccaata agcccaggca actgaaaagt aaatgctatg ttgtactttg      360

atccatggtc acaactcata atcttggaaa agtggacaga aaagacaaaa gagtgaactt      420

taaaactcga atttatttta ccagtatctc ctatgaaggg ctagtaacca aaataatcca      480

cgcatcaggg agagaaatgc cttaaggcat acgttttgga catttagcgt ccctgcaaat      540

tctggccatc gccgcttcct ttgtccatca gaaggcagga aactttatat tggtgacccg      600

tggagctcac attaactatt tacagggtaa ctgcttagga ccagtattat gaggagaatt      660

tacctttccc ccctctcttt ccaagaaaca aggagggggt gaaggtacgg agaacagtat      720

ttcttctgtt gaaagcaact tagctacaaa gataaattac agctatgtac actgaaggta      780

gctatttcat tccacaaaat aagagttttt taaaaagcta tgtatgtatg tgctgcatat      840

agagcagata tacagcctat taagcgtcgt cactaaaaca taaaacatgt cagcctttct      900

taaccttact cgccccagtc tgtcccgacg tgacttcctc gaccctctaa agacgtacag      960

accagacacg gcggcggcgg cgggagaggg gattccctgc gcccccggac ctcagggccg     1020

ctcagattcc tggagaggaa gccaagtgtc cttctgccct cccccggtat cccatccaag     1080

gcgatcagtc cagaactggc tctcggaagc gctcgggcaa agactgcgaa gaagaaaaga     1140

catctggcgg aaacctgtgc gcctggggcg gtggaactcg gggaggagag ggagggatca     1200

gacaggagag tggggactac cccctctgct cccaaattgg ggcagcttcc tgggtttccg     1260

attttctcat ttccgtgggt aaaaaaccct gcccccaccg ggcttacgca atttttttaa     1320

ggggagagga gggaaaaatt tgtggggggt acgaaaaggc ggaaagaaac agtcatttcg     1380

tcacatgggc ttggttttca gtcttataaa aaggaaggtt ctctcggtta gcgaccaatt     1440

gtcatacgac ttgcagtgag cgtcaggagc acgtccagga actcctcagc agcgcctcct     1500

tcagctccac agccagacgc cctcagacag caaagcctac ccccgcgccg cgccctgccc     1560

gccgctg                                                               1567


<210>  29
<211>  266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
gttctttgaa agcagtcgag ggggtgctag gtgtgggcag ggacgagctg gcgcggcgtc       60

gctgggtgca ccgcgaccac gggcagagcc acgcggcggg aggactacaa ctcccggcac      120

accccgcgcc gccccgcctc tactcccaga aggccgcggg gggtggaccg cctaagaggg      180

cgtgcgctcc cgacatgccc cgcggcgcgc cattaaccgc cagatttgaa tcgccggacc      240

cgttggcaga ggtggcggcg gcggca                                           266


<210>  30
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
tccttcggct gcgggccggc tcggctacgc gctctgctcc gagccgctca ctgcatggta       60


<210>  31
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
gggaccagaa gggggtgtgg cctctcaggt cgaggcgggg ttaagggtca taaggcggag       60


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Lys Leu His His Arg Cys Leu Gln Ala Leu Cys Cys Arg Lys Lys Pro 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

His Arg Cys Leu Gln Ala Leu Cys Cys Arg Lys Lys Pro Gly 
1               5                   10                  


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

His Arg Cys Leu Glu Glu Leu Cys Cys Arg Lys Lys Pro Gly 
1               5                   10                  


<210>  36
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

His Arg Cys Leu Gln Gln Leu Cys Cys Arg Lys Lys Pro Gly 
1               5                   10                  


<210>  37
<211>  595
<212>  PRT
<213>  Artificial seuqence

<220>
<223>  Synthetic Polypeptide

<400>  37

Met Pro Ala Cys Cys Ser Cys Ser Asp Val Phe Gln Tyr Glu Thr Asn 
1               5                   10                  15      


Lys Val Thr Arg Ile Gln Ser Met Asn Tyr Gly Thr Ile Lys Trp Phe 
            20                  25                  30          


Phe His Val Ile Ile Phe Ser Tyr Val Cys Phe Ala Leu Val Ser Asp 
        35                  40                  45              


Lys Leu Tyr Gln Arg Lys Glu Pro Val Ile Ser Ser Val His Thr Lys 
    50                  55                  60                  


Val Lys Gly Ile Ala Glu Val Lys Glu Glu Ile Val Glu Asn Gly Val 
65                  70                  75                  80  


Lys Lys Leu Val His Ser Val Phe Asp Thr Ala Asp Tyr Thr Phe Pro 
                85                  90                  95      


Leu Gln Gly Asn Ser Phe Phe Val Met Thr Asn Phe Leu Lys Thr Glu 
            100                 105                 110         


Gly Gln Glu Gln Arg Leu Cys Pro Glu Tyr Pro Thr Arg Arg Thr Leu 
        115                 120                 125             


Cys Ser Ser Asp Arg Gly Cys Lys Lys Gly Trp Met Asp Pro Gln Ser 
    130                 135                 140                 


Lys Gly Ile Gln Thr Gly Arg Cys Val Val Tyr Glu Gly Asn Gln Lys 
145                 150                 155                 160 


Thr Cys Glu Val Ser Ala Trp Cys Pro Ile Glu Ala Val Glu Glu Ala 
                165                 170                 175     


Pro Arg Pro Ala Leu Leu Asn Ser Ala Glu Asn Phe Thr Val Leu Ile 
            180                 185                 190         


Lys Asn Asn Ile Asp Phe Pro Gly His Asn Tyr Thr Thr Arg Asn Ile 
        195                 200                 205             


Leu Pro Gly Leu Asn Ile Thr Cys Thr Phe His Lys Thr Gln Asn Pro 
    210                 215                 220                 


Gln Cys Pro Ile Phe Arg Leu Gly Asp Ile Phe Arg Glu Thr Gly Asp 
225                 230                 235                 240 


Asn Phe Ser Asp Val Ala Ile Gln Gly Gly Ile Met Gly Ile Glu Ile 
                245                 250                 255     


Tyr Trp Asp Cys Asn Leu Asp Arg Trp Phe His His Cys Arg Pro Lys 
            260                 265                 270         


Tyr Ser Phe Arg Arg Leu Asp Asp Lys Thr Thr Asn Val Ser Leu Tyr 
        275                 280                 285             


Pro Gly Tyr Asn Phe Arg Tyr Ala Lys Tyr Tyr Lys Glu Asn Asn Val 
    290                 295                 300                 


Glu Lys Arg Thr Leu Ile Lys Val Phe Gly Ile Arg Phe Asp Ile Leu 
305                 310                 315                 320 


Val Phe Gly Thr Gly Gly Lys Phe Asp Ile Ile Gln Leu Val Val Tyr 
                325                 330                 335     


Ile Gly Ser Thr Leu Ser Tyr Phe Gly Leu Ala Ala Val Phe Ile Asp 
            340                 345                 350         


Phe Leu Ile Asp Thr Tyr Ser Ser Asn Cys Cys Arg Ser His Ile Tyr 
        355                 360                 365             


Pro Trp Cys Lys Cys Cys Gln Pro Cys Val Val Asn Glu Tyr Tyr Tyr 
    370                 375                 380                 


Arg Lys Lys Cys Glu Ser Ile Val Glu Pro Lys Pro Thr Leu Lys Tyr 
385                 390                 395                 400 


Val Ser Phe Val Asp Glu Ser His Ile Arg Met Val Asn Gln Gln Leu 
                405                 410                 415     


Leu Gly Arg Ser Leu Gln Asp Val Lys Gly Gln Glu Val Pro Arg Pro 
            420                 425                 430         


Ala Met Asp Phe Thr Asp Leu Ser Arg Leu Pro Leu Ala Leu His Asp 
        435                 440                 445             


Thr Pro Pro Ile Pro Gly Gln Pro Glu Glu Ile Gln Leu Leu Arg Lys 
    450                 455                 460                 


Glu Ala Thr Pro Arg Ser Arg Asp Ser Pro Val Trp Cys Gln Cys Gly 
465                 470                 475                 480 


Ser Cys Leu Pro Ser Gln Leu Pro Glu Ser His Arg Cys Leu Glu Glu 
                485                 490                 495     


Leu Cys Cys Arg Lys Lys Pro Gly Ala Cys Ile Thr Thr Ser Glu Leu 
            500                 505                 510         


Phe Arg Lys Leu Val Leu Ser Arg His Val Leu Gln Phe Leu Leu Leu 
        515                 520                 525             


Tyr Gln Glu Pro Leu Leu Ala Leu Asp Val Asp Ser Thr Asn Ser Arg 
    530                 535                 540                 


Leu Arg His Cys Ala Tyr Arg Cys Tyr Ala Thr Trp Arg Phe Gly Ser 
545                 550                 555                 560 


Gln Asp Met Ala Asp Phe Ala Ile Leu Pro Ser Cys Cys Arg Trp Arg 
                565                 570                 575     


Ile Arg Lys Glu Phe Pro Lys Ser Glu Gly Gln Tyr Ser Gly Phe Lys 
            580                 585                 590         


Ser Pro Tyr 
        595 


<210>  38
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Phe Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120             


<210>  39
<211>  255
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Asp Val Glu Ser Lys Ser Cys Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 255 


