
                                SEQUENCE LISTING

<110> Nicolaides, Nicholas
      Grasso, Luigi
      Kline, J. Bradford

<120> Composition and use of humoral immune
  suppressor antagonists for the treatment of humoral immune
  suppressed diseases

<130> 008966.00003

<160> 15

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 64
<212> PRT
<213> Homo sapiens

<400> 1
Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile
 1               5                  10                  15
Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val
            20                  25                  30
Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro
        35                  40                  45
Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu
    50                  55                  60

<210> 2
<211> 384
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15
Val His Ser Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala
            20                  25                  30
Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu
        35                  40                  45
Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn
    50                  55                  60
Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu
65                  70                  75                  80
Asp Glu Leu Gly Gly Gly Gly Ser Glu Val Glu Lys Thr Ala Cys Pro
                85                  90                  95
Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys
            100                 105                 110
Lys Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln
        115                 120                 125
Met Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val
    130                 135                 140
Leu Lys His Lys Leu Asp Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr
145                 150                 155                 160
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
                165                 170                 175
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
            180                 185                 190
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
        195                 200                 205
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
    210                 215                 220
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
225                 230                 235                 240
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                245                 250                 255
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
            260                 265                 270
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
        275                 280                 285
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
    290                 295                 300
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
305                 310                 315                 320
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
                325                 330                 335
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
            340                 345                 350
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
        355                 360                 365
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    370                 375                 380

<210> 3
<211> 453
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15
Val His Ser Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala
            20                  25                  30
Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu
        35                  40                  45
Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn
    50                  55                  60
Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu
65                  70                  75                  80
Asp Glu Leu Gly Gly Gly Gly Ser Glu Val Glu Lys Thr Ala Cys Pro
                85                  90                  95
Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys
            100                 105                 110
Lys Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln
        115                 120                 125
Met Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val
    130                 135                 140
Leu Lys His Lys Leu Asp Glu Leu Gly Gly Gly Gly Ser Glu Val Glu
145                 150                 155                 160
Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser
                165                 170                 175
Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val Asp Ala Ala
            180                 185                 190
Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr
        195                 200                 205
Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Glu Pro Lys
    210                 215                 220
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445
Leu Ser Pro Gly Lys
    450

<210> 4
<211> 315
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15
Val His Ser Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala
            20                  25                  30
Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu
        35                  40                  45
Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn
    50                  55                  60
Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu
65                  70                  75                  80
Asp Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
                85                  90                  95
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
            100                 105                 110
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
        115                 120                 125
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
    130                 135                 140
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
145                 150                 155                 160
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
                165                 170                 175
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
            180                 185                 190
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
        195                 200                 205
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
    210                 215                 220
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
225                 230                 235                 240
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
                245                 250                 255
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
            260                 265                 270
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
        275                 280                 285
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
    290                 295                 300
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
305                 310                 315

<210> 5
<211> 8
<212> PRT
<213> Homo sapiens

<400> 5
Gly Tyr Thr Phe Thr Ser Tyr Asn
 1               5

<210> 6
<211> 8
<212> PRT
<213> Homo sapiens

<400> 6
Ile Tyr Pro Gly Asn Gly Asp Thr
 1               5

<210> 7
<211> 14
<212> PRT
<213> Homo sapiens

<400> 7
Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val
 1               5                  10

<210> 8
<211> 6
<212> PRT
<213> Homo sapiens

<400> 8
Ser Ser Ser Val Ser Tyr
 1               5

<210> 9
<211> 3
<212> PRT
<213> Homo sapiens

<400> 9
Ala Thr Ser
 1

<210> 10
<211> 9
<212> PRT
<213> Homo sapiens

<400> 10
Gln Gln Trp Thr Ser Asn Pro Pro Thr
 1               5

<210> 11
<211> 1155
<212> DNA
<213> Homo sapiens

<400> 11
atggggtggt catgtatcat cttgtttctc gtggccaccg cgactggcgt gcattcagag      60
gtggagaaga ccgcctgtcc gagcgggaaa aaggctcgcg agattgatga gtcactgatt     120
ttctacaaaa agtgggaact cgaggcttgc gtagatgcag ctcttctggc tactcaaatg     180
gacagagtaa atgctattcc ttttacttat gaacaattgg acgtattgaa acacaagctg     240
gatgaattgg gaggcggggg gtccgaggtc gagaagacgg cctgtccctc tggaaaaaaa     300
gcaagggaaa ttgacgagag tttgattttc tataagaaat gggagctcga agcatgtgta     360
gatgccgcac tgttggcaac tcaaatggat agggtgaacg caattccctt cacatatgaa     420
caactggatg tacttaagca taagttggac gaattggaac cgaaatcttg tgacaaaacg     480
catacatgtc cgccgtgccc ggcccccgag ctgctggggg gtcctagtgt ctttctcttt     540
ccacctaagc ctaaggatac tctcatgatc tctcgcacac ccgaggtgac atgcgtagtc     600
gtggatgtca gccacgagga tccggaagtt aagtttaact ggtacgtcga cggagttgag     660
gtacacaatg cgaaaacaaa accacgcgag gaacagtata attccacgta ccgagtcgtt     720
tctgttctta cagtgttgca tcaggactgg ttgaatggaa aagaatataa atgcaaggtt     780
tcaaacaagg cactgccggc ccccatcgag aagactataa gcaaagccaa agggcaaccc     840
cgcgaaccac aagtctatac gctccctcca agtcgcgacg aacttaccaa aaaccaggtg     900
tcattgacct gtttggtgaa aggcttttat cccagcgaca tcgcggtgga atgggagtct     960
aacggtcaac ctgagaataa ctacaagact actcctcctg tattggactc tgatggatct    1020
ttttttctct attccaaact gacagttgat aagtctaggt ggcagcaagg gaatgtcttt    1080
agttgtagcg tgatgcatga agcattgcat aaccactata ctcaaaagtc cctgagcttg    1140
tccccgggga agtga                                                     1155

<210> 12
<211> 384
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15
Val His Ser Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala
            20                  25                  30
Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu
        35                  40                  45
Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn
    50                  55                  60
Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu
65                  70                  75                  80
Asp Glu Leu Gly Gly Gly Gly Ser Glu Val Glu Lys Thr Ala Cys Pro
                85                  90                  95
Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys
            100                 105                 110
Lys Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln
        115                 120                 125
Met Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val
    130                 135                 140
Leu Lys His Lys Leu Asp Glu Leu Glu Pro Lys Ser Cys Asp Lys Thr
145                 150                 155                 160
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
                165                 170                 175
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
            180                 185                 190
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
        195                 200                 205
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
    210                 215                 220
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
225                 230                 235                 240
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                245                 250                 255
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
            260                 265                 270
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
        275                 280                 285
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
    290                 295                 300
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
305                 310                 315                 320
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
                325                 330                 335
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
            340                 345                 350
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
        355                 360                 365
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
    370                 375                 380

<210> 13
<211> 1362
<212> DNA
<213> Homo sapiens

<400> 13
atggggtggt catgtatcat cttgtttctc gtggccaccg cgactggcgt gcattcagag      60
gtggagaaga ccgcctgtcc gagcgggaaa aaggctcgcg agattgatga gtcactgatt     120
ttctacaaaa agtgggaact cgaggcttgc gtagatgcag ctcttctggc tactcaaatg     180
gacagagtaa atgctattcc ttttacttat gaacaattgg acgtattgaa acacaagctg     240
gatgaattgg gaggcggggg gtccgaggtc gagaagacgg cctgtccctc tggaaaaaaa     300
gcaagggaaa ttgacgagag tttgattttc tataagaaat gggagctcga agcatgtgta     360
gatgccgcac tgttggcaac tcaaatggat agggtgaacg caattccctt cacatatgaa     420
caactggatg tacttaagca taagttggac gaattgggag gcggggggtc cgaggtcgag     480
aagacggcct gtccctctgg aaaaaaagca agggaaattg acgagagttt gattttctat     540
aagaaatggg agctcgaagc atgtgtagat gccgcactgt tggcaactca aatggatagg     600
gtgaacgcaa ttcccttcac atatgaacaa ctggatgtac ttaagcataa gttggacgaa     660
ttggaaccga aatcttgtga caaaacgcat acatgtccgc cgtgcccggc ccccgagctg     720
ctggggggtc ctagtgtctt tctctttcca cctaagccta aggatactct catgatctct     780
cgcacacccg aggtgacatg cgtagtcgtg gatgtcagcc acgaggatcc ggaagttaag     840
tttaactggt acgtcgacgg agttgaggta cacaatgcga aaacaaaacc acgcgaggaa     900
cagtataatt ccacgtaccg agtcgtttct gttcttacag tgttgcatca ggactggttg     960
aatggaaaag aatataaatg caaggtttca aacaaggcac tgccggcccc catcgagaag    1020
actataagca aagccaaagg gcaaccccgc gaaccacaag tctatacgct ccctccaagt    1080
cgcgacgaac ttaccaaaaa ccaggtgtca ttgacctgtt tggtgaaagg cttttatccc    1140
agcgacatcg cggtggaatg ggagtctaac ggtcaacctg agaataacta caagactact    1200
cctcctgtat tggactctga tggatctttt tttctctatt ccaaactgac agttgataag    1260
tctaggtggc agcaagggaa tgtctttagt tgtagcgtga tgcatgaagc attgcataac    1320
cactatactc aaaagtccct gagcttgtcc ccggggaagt ga                       1362

<210> 14
<211> 453
<212> PRT
<213> Homo sapiens

<400> 14
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15
Val His Ser Glu Val Glu Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala
            20                  25                  30
Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu
        35                  40                  45
Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met Asp Arg Val Asn
    50                  55                  60
Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu Lys His Lys Leu
65                  70                  75                  80
Asp Glu Leu Gly Gly Gly Gly Ser Glu Val Glu Lys Thr Ala Cys Pro
                85                  90                  95
Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys
            100                 105                 110
Lys Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln
        115                 120                 125
Met Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val
    130                 135                 140
Leu Lys His Lys Leu Asp Glu Leu Gly Gly Gly Gly Ser Glu Val Glu
145                 150                 155                 160
Lys Thr Ala Cys Pro Ser Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser
                165                 170                 175
Leu Ile Phe Tyr Lys Lys Trp Glu Leu Glu Ala Cys Val Asp Ala Ala
            180                 185                 190
Leu Leu Ala Thr Gln Met Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr
        195                 200                 205
Glu Gln Leu Asp Val Leu Lys His Lys Leu Asp Glu Leu Glu Pro Lys
    210                 215                 220
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445
Leu Ser Pro Gly Lys
    450

<210> 15
<211> 5
<212> PRT
<213> Homo sapiens

<400> 15
Gly Gly Gly Gly Ser
 1               5
