                               SEQUENCE LISTING

<110> MODERNA TX, INC.
 
<120> COMPOSITIONS AND METHODS FOR ENHANCED DELIVERY OF AGENTS

<130> M2180-7000WO

<140>
<141>

<150> 62/884,133
<151> 2019-08-07

<160> 181   

<170> PatentIn version 3.5

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<210> 60
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 60
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca cc                                     92


<210> 61
<211> 119
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 61
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc cccccagccc       60

ctcctcccct tcctgcaccc gtacccccgt ggtctttgaa taaagtctga gtgggcggc       119


<210> 62
<211> 164
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 62
tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggccca aacaccattg       60

tcacactcca tccccccagc ccctcctccc cttcctccat aaagtaggaa acactacatg      120

cacccgtacc cccgtggtct ttgaataaag tctgagtggg cggc                       164


<210> 63
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 64
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 64
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210> 65
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 65
tccggactca gatccgggga tctcaaaatt gtcgctcctg tcaaacaaac tcttaacttt       60

gatttactca aactggctgg ggatgtagaa agcaatccag gtccactc                   108


<210> 66
<211> 87
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      mmiR-142 sequence"

<400> 66
gacagugcag ucacccauaa aguagaaagc acuacuaaca gcacuggagg guguaguguu       60

uccuacuuua uggaugagug uacugug                                           87


<210> 67
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      mmiR-142-3p sequence"

<400> 67
uguaguguuu ccuacuuuau gga                                               23


<210> 68
<211> 23
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      mmiR-142-3p binding site sequence"

<400> 68
uccauaaagu aggaaacacu aca                                               23


<210> 69
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      mmiR-142-5p sequence"

<400> 69
cauaaaguag aaagcacuac u                                                 21


<210> 70
<211> 21
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      mmiR-142-5p binding site sequence"

<400> 70
aguagugcuu ucuacuuuau g                                                 21


<210> 71
<211> 85
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-122 sequence"

<400> 71
ccuuagcaga gcuguggagu gugacaaugg uguuuguguc uaaacuauca aacgccauua       60

ucacacuaaa uagcuacugc uaggc                                             85


<210> 72
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-122-3p sequence"

<400> 72
aacgccauua ucacacuaaa ua                                                22


<210> 73
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-122-3p binding site sequence"

<400> 73
uauuuagugu gauaauggcg uu                                                22


<210> 74
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-122-5p sequence"

<400> 74
uggaguguga caaugguguu ug                                                22


<210> 75
<211> 22
<212> RNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      miR-122-5p binding site sequence"

<400> 75
caaacaccau ugucacacuc ca                                                22


<210> 76
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210> 77
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 77
gggaaataag agagaaaaga agagtaagaa gaaatataag a                           41


<210> 78
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
gggaaataag agagaaaaga agagtaagaa gaaatataag accccggcgc cgccacc          57


<210> 79
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
gggaaataag agagaaaaga agagtaagaa gaaatataag accccggcgc cacc             54


<210> 80
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 80
ccccggcgcc                                                              10


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<400> 175
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<210> 176

<400> 176
000


<210> 177
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 177
ccgccgccgc cg                                                           12


<210> 178
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 178
ccgccgccgc cgccg                                                        15


<210> 179
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 179
Asn Pro Gly Pro 
1               


<210> 180
<211> 30
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(30)
<223> /note="This sequence may encompass 1 to 10, 2 to 8, 3 to 6, 
      or 4 to 5 'ccg' repeating units"

<400> 180
ccgccgccgc cgccgccgcc gccgccgccg                                        30


<210> 181
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> misc_feature
<222> (1)..(15)
<223> /note="This sequence may encompass 1-5 'ccg' repeating units"

<400> 181
ccgccgccgc cgccg                                                        15


