
                                SEQUENCE LISTING

<110> CytoDyn Inc. 

<120> METHODS FOR TREATING OR PREVENTING CANCERS INVOLVING THE ADMINISTRATION OF ANTI-CCR5 RECEPTOR AGENTS 

<130> 230042.429WO

<140> PCT
<141> 2020-07-31

<150> US 63/047,693
<151> 2020-07-02

<150> US 62/882,353
<151> 2019-08-02

<160> 15

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antidoby PRO140 VL

<220>
<221> sig_peptide
<222> 1...19 
<223> signal peptide at amino acids 1-19

<400> 1
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala
 1               5                  10                  15
Ser Ser Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val
            20                  25                  30
Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu
        35                  40                  45
Leu Ser Ser Tyr Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro
    50                  55                  60
Gly Gln Ser Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser
65                  70                  75                  80
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                85                  90                  95
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
            100                 105                 110
Ser Gln Ser Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val
        115                 120                 125
Glu Ile Lys
    130

<210> 2
<211> 429
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody PRO140 VL

<400> 2
tctagaccac catgaagttg cctgttaggc tgttggtgct gatgttctgg attcctgctt      60
ccagcagtga tattgtgatg acccaatctc cactctccct gcctgtcact cctggagagc     120
cagcctccat ctcttgcaga tctagtcagc gccttctgag cagttatgga catacctatt     180
tacattggta cctacagaag ccaggccagt ctccacagct cctgatctac gaagtttcca     240
accgattttc tggggtccca gacaggttca gtggcagtgg gtcagggaca gatttcacac     300
ttaagatcag tagagtggag gctgaggatg tgggagttta ttactgctct caaagtacac     360
atgttcctct cacgttcgga caggggacca aggtggaaat aaaacgtaag tagtcttctc     420
aactctaga                                                             429

<210> 3
<211> 141
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody PRO140 #2 VH

<220>
<221> sig_peptide
<222> 1...19 
<223> signal peptide at amino acids 1-19

<400> 3
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly
 1               5                  10                  15
Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys
            20                  25                  30
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe
        35                  40                  45
Ser Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn
65                  70                  75                  80
Glu Lys Phe Lys Asp Lys Thr Thr Leu Ser Ala Asp Thr Ser Lys Asn
                85                  90                  95
Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val
            100                 105                 110
Tyr Tyr Cys Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe
        115                 120                 125
Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140

<210> 4
<211> 457
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody PRO#2 VH

<400> 4
acgcgtccac catggaatgg agcggagtct ttatctttct cctgtcagta actgcaggtg      60
tccactccga ggtgcagctg gtggagtctg gtggaggctt ggtaaagcct ggaggttccc     120
ttagactctc ctgtgcagcc tctggttaca ctttcagtaa ctattggatc ggatgggtcc     180
gccaggctcc aggcaaaggg ctggagtgga ttggcgatat ctaccctgga gggaactaca     240
tcaggaacaa tgagaagttc aaggacaaga ccaccctgtc agcagatact tccaagaaca     300
cagcctatct gcaaatgaac agcctgaaaa ccgaggacac agccgtgtat tactgtggaa     360
gcagcttcgg tagtaactac gtgttcgcct ggtttactta ctggggccaa gggactctgg     420
tcacagtctc ctcaggtgag tccttaaaac ctctaga                              457

<210> 5
<211> 141
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody PRO140#1 VH

<220>
<221> sig_peptide
<222> 1...19 
<223> signal peptide at amino acids 1-19

<400> 5
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly
 1               5                  10                  15
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Pro Asp Val Lys Lys
            20                  25                  30
Pro Gly Thr Ser Met Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe
        35                  40                  45
Ser Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn
65                  70                  75                  80
Glu Lys Phe Lys Asp Lys Thr Thr Leu Thr Ala Asp Thr Ser Thr Ser
                85                  90                  95
Thr Ala Tyr Met Gln Leu Gly Ser Leu Arg Ser Glu Asp Thr Ala Val
            100                 105                 110
Tyr Tyr Cys Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe
        115                 120                 125
Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140

<210> 6
<211> 457
<212> DNA
<213> Artificial Sequence

<220> 
<223> Humanized antibody PRO#1 VH

<400> 6
tctagaccac catggaatgg agcggggtct ttatctttct cctgtcagta actgcaggtg      60
tccactccca ggtccaactg gtgcagtctg gacctgatgt gaaaaagcct gggacttcaa     120
tgaagatgtc ctgcaagacg tctggataca ccttcagtaa ctattggatc ggatgggtta     180
ggcaggcgcc tggacaaggc cttgagtgga ttggagatat ttaccctgga gggaactata     240
tcaggaacaa tgagaagttc aaggacaaga ccacactgac ggcagacaca tcgaccagca     300
cggcctacat gcaacttggc agcctgagat ctgaagacac tgccgtctat tactgtggaa     360
gcagcttcgg tagtaactac gtgttcgcct ggtttactta ctggggccaa gggactctgg     420
tcacagtctc ctcaggtgag tccttaaaac ctctaga                              457

<210> 7
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody heavy chain

<400> 7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser Asn Tyr
            20                  25                  30
Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45
Gly Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn Glu Lys Phe
    50                  55                  60
Lys Asp Lys Thr Thr Leu Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Gly Ser Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe Thr Tyr Trp
            100                 105                 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro
        115                 120                 125
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr
    130                 135                 140
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190
Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp
        195                 200                 205
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr
    210                 215                 220
Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro
225                 230                 235                 240
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp
            260                 265                 270
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val
    290                 295                 300
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys
                325                 330                 335
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350
Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys
                405                 410                 415
Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly
        435                 440                 445
Lys


<210> 8
<211> 219
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody light chain

<400> 8
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
 1               5                  10                  15
Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Arg Leu Leu Ser Ser
            20                  25                  30
Tyr Gly His Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45
Pro Gln Leu Leu Ile Tyr Glu Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser
                85                  90                  95
Thr His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105                 110
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
        115                 120                 125
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
    130                 135                 140
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
145                 150                 155                 160
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
                165                 170                 175
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
            180                 185                 190
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
        195                 200                 205
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215

<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody LCDR1

<400> 9
Arg Ser Ser Gln Arg Leu Leu Ser Ser Tyr Gly His Thr Tyr Leu His
 1               5                  10                  15

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody LCDR2

<400> 10
Glu Val Ser Asn Arg Phe Ser
 1               5

<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody LCDR3

<400> 11
Ser Gln Ser Thr His Val Pro Leu Thr
 1               5

<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody HCDR1

<400> 12
Asn Tyr Trp Ile Gly
 1               5

<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody HCDR2

<400> 13
Asp Ile Tyr Pro Gly Gly Asn Tyr Ile Arg Asn Asn Glu Lys Phe Lys
 1               5                  10                  15
Asp


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Humanized antibody HCDR3

<400> 14
Ser Phe Gly Ser Asn Tyr Val Phe Ala Trp Phe Thr Tyr
 1               5                  10

<210> 15
<211> 352
<212> PRT
<213> Homo sapiens

<220> 
<223> CCR5 NCBI Reference Sequence: NP_000570.1

<400> 15
Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr
 1               5                  10                  15
Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu
            20                  25                  30
Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn
        35                  40                  45
Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met
    50                  55                  60
Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu
65                  70                  75                  80
Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe
                85                  90                  95
Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe
            100                 105                 110
Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu
        115                 120                 125
Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe
    130                 135                 140
Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser
145                 150                 155                 160
Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr
                165                 170                 175
Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn
            180                 185                 190
Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu
        195                 200                 205
Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys
    210                 215                 220
Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile
225                 230                 235                 240
Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu
                245                 250                 255
Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser
            260                 265                 270
Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr
        275                 280                 285
His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe
    290                 295                 300
Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe
305                 310                 315                 320
Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser
                325                 330                 335
Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu
            340                 345                 350
